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https://www.readbyqxmd.com/read/29339919/effect-of-oral-tranexamic-acid-on-macular-edema-associated-with-retinal-vein-occlusion-or-diabetes
#1
Masayuki Takeyama, Fumio Takeuchi, Masahiko Gosho, Keijiro Sugita, Masahiro Zako, Masayoshi Iwaki, Motohiro Kamei
Purpose: Tranexamic acid (TXA) is a widely used antifibrinolytic agent that can also cause a decrease in vascular permeability. We hypothesized that TXA could improve macular edema (ME) that is caused by an increase in retinal vascular permeability. The aim of this study is to evaluate the efficacy of oral TXA for ME associated with retinal vein occlusion (RVO) or diabetic ME (DME). Patients and methods: Oral TXA (1,500 mg daily for 2 weeks) was administered to patients with persistent ME secondary to RVO (7 eyes) and DME (7 eyes)...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29326850/the-efficacy-and-safety-of-intravitreal-dexamethasone-implant-for-the-treatment-of-macular-edema-related-to-retinal-vein-occlusion-real-life-data-and-prognostic-factors-in-a-turkish-population
#2
Ayşe Yağmur Kanra, Aylin Ardagil Akçakaya, Sevil Arı Yaylalı, Meltem Güzin Altınel, Neslihan Sevimli
Objectives: To evaluate the efficacy and safety of dexamethasone (DEX) implants as mono or combination therapy for macular edema in retinal vein occlusion (RVO) with real-life conditions, and to detect factors that influence final visual acuity. Materials and Methods: Twenty-five eyes with macular edema secondary to RVO underwent assessments for central macular thickness (CMT), best-corrected visual acuity (BCVA), adverse events, and also morphologic changes in optical coherence tomography at an interval of 4-8 weeks after at least one DEX implant...
December 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29317400/two-year-outcomes-of-intravitreal-ziv-aflibercept
#3
Ahmad M Mansour, Mohammed Ashraf, Abdulrazzak Charbaji, Muhammad H Younis, Ahmed A Souka, Avantika Dogra, Hana A Mansour, Jay Chhablani
AIM: To assess the two-year outcome of intravitreal ziv-aflibercept (IVZ) in eyes with macular diseases. METHODS: Consecutive subjects with various macular diseases that received six or more of 0.05 mL IVZ (1.25 mg) injections with at least 1 year follow-up were included. Outcome measures were best-corrected visual acuity (BCVA) (logarithm of the minimum angle of resolution) and central macular thickness (CMT) on spectral domain optical coherence tomography...
January 9, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29278975/oxidant-antioxidant-balance-in-the-aqueous-humor-of-patients-with-retinal-vein-occlusion
#4
Muhammed Altinisik, Arif Koytak, Ahmet Elbay, Enes Toklu, Taha Sezer, Abdurrahim Kocyigit
PURPOSE: To analyze oxidative stress parameters in the aqueous humor with retinal vein occlusion. MATERIALS AND METHODS: A total of 56 patients who underwent cataract surgery were enrolled in this study. The eyes with retinal vein occlusion were included in the study group. Aqueous humor was sampled from all patients and analyzed by an automated measurement method. Total oxidant status (TOS), total antioxidant status (TAS), and oxidative stres index (OSI) were calculated...
December 26, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29274022/outcome-of-treat-and-monitor-regimen-of-aflibercept-and-ranibizumab-in-macular-edema-secondary-to-non-ischemic-branch-retinal-vein-occlusion
#5
Francesco Pichi, Ahmed Mohammed Elbarky, Tarek Roshdy Elhamaky
PURPOSE: To compare the efficacy of a modified PRN treatment regimen ("treat and monitor") of aflibercept and ranibizumab in macular edema secondary to non-ischemic branch retinal vein occlusion. METHODS: Seventy eyes of 70 patients with treatment naïve branch retinal vein occlusion were enrolled. All patients underwent a comprehensive ophthalmic examination, spectral-domain optical coherence tomography, and fluorescein angiography. Patients were randomized 1:1 to receive intravitreal aflibercept (34 eyes) and ranibizumab (36 eyes) with a "treat and monitor" treatment regimen with monthly follow-up for 12 months...
December 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29260119/one-year-outcomes-of-ziv-aflibercept-for-macular-edema-in-central-retinal-vein-occlusion
#6
Mohab Eldeeb, Errol W Chan, Chintan J Dedhia, Ahmad Mansour, Jay Chhablani
Purpose: To report the 12-month efficacy and safety outcomes of intravitreal ziv-aflibercept in macular edema secondary to central retinal vein occlusion (CRVO). Methods: Interventional case series documenting 12-month outcomes of intravitreal ziv-aflibercept (1.25 mg in 0.05 mL) in 6 patients with treatment-naive macular edema secondary to CRVO. All patients had comprehensive ophthalmic examination, spectral domain optical coherence tomography at baseline and all follow-up visits, and fluorescein...
December 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29234221/aflibercept-in-macular-edema-secondary-to-retinal-vein-occlusion-a-real-life-study
#7
Abdullah Ozkaya, Beril Tulu, Ruveyde Garip
Purpose: To evaluate the real life outcomes of intravitreal aflibercept (IVAfl) treatment in patients with macular edema (ME) secondary to retinal vein occlusion (RVO) during the first year of treatment. Methods: Retrospective case series. Newly diagnosed or persistent ME patients secondary to RVO who were treated with IVAfl and had a follow-up period of at least 12 months were included. Twenty-two patients (54.8%) received 3 loading month loading doses IVAfl initially, whereas 20 patients (45...
October 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29225460/intravitreal-bevacizumab-injections-versus-dexamethasone-implant-for-treatment-na%C3%A3-ve-retinal-vein-occlusion-related-macular-edema
#8
Ilkka Laine, Juha-Matti Lindholm, Petteri Ylinen, Raimo Tuuminen
Purpose: To compare the short-term effects of three monthly intravitreal bevacizumab (IVB) injections to single dexamethasone (DEX) implantation in treatment-naïve patients with cystoid macular edema (CME) secondary to branch (BRVO) and central retinal vein occlusion (CRVO). Design: A retrospective single-center study. Subjects: A total of 135 eyes of 135 patients with BRVO (n=83) and CRVO (n=52). Methods: Changes in clinical parameters were recorded before treatment and at the first and third month after commencement of IVB (n=121) and DEX (n=14)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29222552/animal-models-of-retinal-vein-occlusion
#9
Meiaad Khayat, Noemi Lois, Michael Williams, Alan W Stitt
Purpose: To provide a comprehensive and current review on the available experimental animal models of retinal vein occlusion (RVO) and to identify their strengths and limitations with the purpose of helping researchers to plan preclinical studies on RVO. Methods: A systematic review of the literature on experimental animal models of RVO was undertaken. Medline, SCOPUS, and Web of Science databases were searched. Studies published between January 1, 1965, and March 31, 2017, and that met the inclusion criteria were reviewed...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29190240/comparing-microperimetric-and-structural-findings-in-patients-with-branch-retinal-vein-occlusion-and-diabetic-macular-edema
#10
Amun Sachdev, Magdalena Edington, Rupal Morjaria, Victor Chong
PURPOSE: To compare retinal sensitivity and central retinal thickness in patients with focal diabetic macular edema (DME) and edema secondary to branch retinal vein occlusion (BRVO). METHODS: In this consecutive, cross-sectional, observational study, patients with either DME or BRVO underwent measurements for best-corrected visual acuity, microperimetry, and spectral domain optical coherence tomography. Retinal thickness and sensitivity were measured using Optos Spectral optical coherence tomography/scanning laser ophthalmoscopy (Optos plc, Dunfermline, Scotland, United Kingdom)...
November 22, 2017: Retina
https://www.readbyqxmd.com/read/29185408/high-altitude-retinopathy-presenting-as-central-retinal-vein-occlusion-in-a-soldier
#11
Waseem Raja, Ahsan Mukhtar
A 33-year soldier, deployed at an altitude of 3,350 meters for two years, developed unilateral Central Retinal Vein Occlusion (CRVO) in the left eye. He had no risk factor for thrombosis and all thrombophilia screenings were negative. The patient was managed with intravitreal injections of anti-VEGF (Bevacizumab) every four weeks. He showed gradual improvement in the visual acuity over the next 3 months. Best corrected visual acuity (BCVA) after three months was 6/7.5; whereas, initially it was limited to hand movements only...
December 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29185099/real-life-clinical-data-for-dexamethasone-and-ranibizumab-in-the-treatment-of-branch-or-central-retinal-vein-occlusion-over-a-period-of-six-months
#12
Sibylle Winterhalter, Annabelle Eckert, Gerrit-Alexander Vom Brocke, Alice Schneider, Dominika Pohlmann, Daniel Pilger, Antonia M Joussen, Matus Rehak, Ulrike Grittner
PURPOSE: To evaluate the therapeutic outcome for dexamethasone implant (DEX) or intravitreal ranibizumab (IVR) injections over 6 months in patients with macular edema due to branch or central retinal vein occlusion (BRVO, CRVO), in a real-life setting. METHODS: A total of 107 patients with BRVO or CRVO were included into this retrospective single-center observational study. Patients were treated with monotherapy consisting of DEX or three monthly IVR injections following a pro re nata regimen (PRN)...
November 28, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29176528/paracentral-acute-middle-maculopathy-in-a-perivenular-fern-like-distribution-with-en-face-optical-coherence-tomography
#13
Sean T Garrity, Victoria L Tseng, David Sarraf
PURPOSE: To report a case of central retinal vein occlusion resulting in a perivenular pattern of paracentral acute middle maculopathy lesions best identified with en face optical coherence tomography (OCT). METHODS: Retrospective case report. Optos ultra-widefield fluorescein angiography, spectral domain OCT, en face OCT, and OCT angiography were performed. RESULTS: A 41-year-old man presented with decreased vision in the right eye for 2 weeks...
November 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29174301/dynamic-changes-in-retinal-vessel-diameter-during-acute-hyperglycemia-in-type-1-diabetes
#14
Brian C Bucca, David M Maahs, Janet K Snell-Bergeon, John Hokanson, Sean Rinella, Franziska Bishop, Alexis Boufard, Joanna Homann, Carol Y Cheung, Tien Y Wong
AIMS: To investigate changes in retinal vessel diameter during acute hyperglycemia in patients with type 1 diabetes. METHODS: We conducted a study on 11 subjects with type 1 diabetes. Euglycemia was maintained for 3h followed by induction of hyperglycemia and simultaneous bolus of rapid acting insulin. Two fundus photos were captured during euglycemia and five fundus photos, blood glucose and blood pressure were taken every 30min for 2.5h post-prandial. Central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) were measured over the study visit and examined using generalized linear mixed models...
October 24, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29161237/bilateral-visual-field-defects-in-a-patient-treated-with-the-mek-and-braf-inhibitors-trametinib-and-dabrafenib-for-melanoma-of-unknown-origin
#15
Jakob Siedlecki, Marc Mackert, Armin Wolf, Carola Berking, Siegfried G Priglinger, Kirsten Eibl-Lindner
INTRODUCTION: Although the introduction of BRAF and MEK inhibitors has greatly enhanced treatment possibilities in advanced BRAFV600-mutated melanoma, class-related toxicities are rather frequent and often involve the eye. Ophthalmologic side effects most commonly include central/diffuse serous retinopathy and retinal vein occlusion. Affection of the optic nerve head however has not been described clinically. CASE REPORT: A 29-year-old man presented in our eye clinic with bilateral blurred vision...
April 17, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29158262/the-epac-rap1-pathway-prevents-and-reverses-cytokine-induced-retinal-vascular-permeability
#16
Carla J Ramos, Chengmao Lin, Xuwen Liu, David A Antonetti
Increased retinal vascular permeability contributes to macular edema, a leading cause of vision loss in eye pathologies such as diabetic retinopathy, age-related macular degeneration, and central retinal vein occlusions. Pathological changes in vascular permeability are driven by growth factors such as VEGF and by pro-inflammatory cytokines such as TNF-α. Identifying the pro-barrier mechanisms that block vascular permeability and restore the blood-retinal barrier (BRB) may lead to new therapies. The cAMP-dependent guanine nucleotide exchange factor EPAC promotes exchange of GTP in the small GTPase Rap1...
November 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29136662/protective-effect-of-metformin-against-retinal-vein-occlusions-in-diabetes-mellitus-a-nationwide-population-based-study
#17
Tai-Chi Lin, De-Kuang Hwang, Chih-Chien Hsu, Chi-Hsien Peng, Mong-Lien Wang, Shih-Hwa Chiou, Shih-Jen Chen
Previous studies have found that metformin can reduce cardiovascular risk, but its association with retinal vein occlusion (RVO) is unknown. In this population-based cohort study using the Taiwan National Health Insurance Research Database (NHIRD), we demonstrated the protective effect of metformin against RVO in diabetes mellitus (DM) and explored the incidence rate and factors associated with RVO development in general and diabetic populations. One million patients were randomly selected from the registry files of the NHIRD, and all their claims data were collected for the 1996-2011 period...
2017: PloS One
https://www.readbyqxmd.com/read/29133663/combined-central-retinal-artery-and-vein-occlusion-with-optic-perineuritis-following-herpes-zoster-dermatitis-in-an-immunocompetent-child
#18
Reema Bansal, Ramandeep Singh, Aastha Takkar, Vivek Lal
A 15-year-old healthy boy developed acute, rapidly progressing visual loss in left eye following herpes zoster dermatitis, with a combined central retinal artery occlusion (CRAO) and central retinal vein occlusion (CRVO), along with optic perineuritis. Laboratory tests were negative. Despite an empirical, intensive antiviral treatment with systemic corticosteroids, and vision could not be restored in the affected eye. Herpes zoster dermatitis, in an immunocompetent individual, may be associated with a combined CRAO and CRVO along with optic perineuritis, leading to profound visual loss...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29133654/-dye-front-reciprocation-in-combined-central-retinal-vein-occlusion-with-cilioretinal-artery-infarction
#19
Raghav Ravani, Rohan Chawla, Shreyans Jain, Atul Kumar
No abstract text is available yet for this article.
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29126927/mechanisms-of-macular-edema-beyond-the-surface
#20
REVIEW
Alejandra Daruich, Alexandre Matet, Alexandre Moulin, Laura Kowalczuk, Michaël Nicolas, Alexandre Sellam, Pierre-Raphaël Rothschild, Samy Omri, Emmanuelle Gélizé, Laurent Jonet, Kimberley Delaunay, Yvonne De Kozak, Marianne Berdugo, Min Zhao, Patricia Crisanti, Francine Behar-Cohen
Macular edema consists of intra- or subretinal fluid accumulation in the macular region. It occurs during the course of numerous retinal disorders and can cause severe impairment of central vision. Major causes of macular edema include diabetes, branch and central retinal vein occlusion, choroidal neovascularization, posterior uveitis, postoperative inflammation and central serous chorioretinopathy. The healthy retina is maintained in a relatively dehydrated, transparent state compatible with optimal light transmission by multiple active and passive systems...
November 7, 2017: Progress in Retinal and Eye Research
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