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Post operative cognitive dysfunction

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https://www.readbyqxmd.com/read/29756691/cerebrovascular-autoregulation-impairments-during-cardiac-surgery-with-cardiopulmonary-bypass-are-related-to-postoperative-cognitive-deterioration-prospective-observational-study
#1
Birute Kumpaitiene, Milda Svagzdiene, Edmundas Sirvinskas, Virginija Adomaitiene, Vytautas Petkus, Rolandas Zakelis, Solventa Krakauskaite, Romanas Chomskis, Arminas Ragauskas, Teodoro F Dagi, Rimantas Benetis
BACKGROUND: Post-operative cognitive dysfunction (POCD) occurs in approximately 33-83% of patients after cardiac surgery with cardiopulmonary bypass (CPB). Recent clinical data suggest that real-time, intraoperative monitoring of patient- specific cerebrovascular autoregulation (CA) may help to prevent POCD by detecting individual critical limits for mean arterial pressure (MAP) outside which CA is impaired. Objectives of the study were to detect the episodes of impaired CA during cardiac surgery with CPB, and to investigate the association between CA impairment and POCD...
May 11, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29616521/the-relationship-between-cerebral-oxygen-saturation-and-quantitative-metrics-of-neurological-function-after-coronary-bypass-surgery-a-feasibility-study
#2
Joanna S Semrau, Stephen H Scott, Andrew G Hamilton, Dimitri Petsikas, Darrin M Payne, Gianluigi Bisleri, Tarit Saha, J Gordon Boyd
BACKGROUND: It is well-known that patients undergoing coronary artery bypass grafting (CABG) surgery may experience neurological dysfunction following their operation. However, the nature of this dysfunction has not been properly quantified. Furthermore, the relationship between post-operative impairment and cerebral oxygen saturation during surgery has remained unclear. This study aims to define the feasibility of using robotic technology to quantify post- CABG neurocognitive function, and to correlate these objective metrics with intraoperative brain tissue oxygen...
April 3, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29580893/d-cycloserine-facilitates-reversal-in-an-animal-model-of-post-traumatic-stress-disorder
#3
Sophie A George, Mariana Rodriguez-Santiago, John Riley, James L Abelson, Stan B Floresco, Israel Liberzon
Many psychiatric disorders are associated with cognitive dysfunction that is ineffectively treated by existing pharmacotherapies and which may contribute to poor real-world functioning. D-cycloserine (DCS) is a partial N-methyl-D-aspartate (NMDA) agonist that has attracted attention because of its cognitive enhancing properties, including in people with post-traumatic stress disorder (PTSD). Here, we examined the effect of DCS on reversal learning - a type of cognitive flexibility - following exposure to single prolonged stress (SPS), a rodent model of PTSD...
March 23, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29505513/impact-of-inhalational-anesthetics-on-postoperative-cognitive-function-study-protocol-of-a-systematic-review-and-meta-analysis
#4
REVIEW
Yi-Qing Zou, Xiao-Bao Li, Zhi-Xing Yang, Jing-Min Zhou, Yi-Nan Wu, Zhi-Hu Zhao, Xiang-Zhu Liu, Chang-Li Hu
BACKGROUND: Conflict findings of the impact of inhalational anesthetics on postoperative cognitive function are reported. No systematic review has been performed to solve the problem. The aim of the study was to assess the effect of different inhalational anesthetics on postoperative cognitive function in a network meta-analysis. METHODS: We will search MEDLINE, EMBASE, the Central Register of Controlled Trials in the Cochrane library, and CINAHL for randomized controlled trials or cohort studies assessing the short-term or long-term cognitive function of elderly patients (over 60 years) receiving major surgeries and inhalational anesthetics (desflurane, isoflurane, sevoflurane, halothane, and nitrous oxide) during surgery...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29496229/intravenous-lidocaine-infusion
#5
G Soto, M Naranjo González, F Calero
Systemic lidocaine used in continuous infusion during the peri-operative period has analgesic, anti-hyperalgesic, as well as anti-inflammatory properties. This makes it capable of reducing the use of opioids and inhalational anaesthetics, and the early return of bowel function, and patient hospital stay. The aim of this narrative review was to highlight the pharmacology and indications for clinical application, along with new and interesting research areas. The clinical applications of peri-operative lidocaine infusion have been reviewed in several recent systematic reviews and meta-analyses in patients undergoing open and laparoscopic abdominal procedures, ambulatory procedures, and other types of surgery...
May 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29398338/diagnostic-accuracy-of-lip-force-and-tongue-strength-for-sarcopenic-dysphagia-in-older-inpatients-a-cross-sectional-observational-study
#6
Kotomi Sakai, Enri Nakayama, Haruka Tohara, Osamu Takahashi, Sayako Ohnishi, Hidetaka Tsuzuki, Mayumi Hayata, Takahiro Takehisa, Yozo Takehisa, Koichiro Ueda
BACKGROUND & AIMS: Dysphagia can be caused by sarcopenia in older adults. Although sarcopenic dysphagia has been reported to be associated with low tongue strength, whether tongue strength can be useful as a diagnostic index for sarcopenic dysphagia remains unclear. In addition, the association between sarcopenic dysphagia and lip force is unknown. The aim of the present study was to clarify the association of lip force and tongue strength with sarcopenic dysphagia, and their diagnostic accuracy for sarcopenic dysphagia...
February 2, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29302117/an-in-vitro-study-comparing-the-gme-handling-of-two-contemporary-oxygenators
#7
Carl J Gisnarian, Angela Hedman, Kenneth G Shann
Gaseous microemboli (GME) are a potential complication of cardiopulmonary bypass (CPB). Though it is difficult to prove that GME is the only major cause of neurological deficits, it may increase the chance of post-operative cognitive dysfunction if not removed. The objectives of this research were to compare LivaNova-Sorin Inspire (Inspire) oxygenator with a Medtronic arterial filter to the Medtronic Fusion (Fusion) oxygenator with and without a Medtronic arterial filter based on each system's ability to handle GME...
December 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/29284552/retrospective-and-prospective-memory-among-oef-oif-ond-veterans-with-a-self-reported-history-of-blast-related-mtbi
#8
Kathleen F Pagulayan, Holly Rau, Renee Madathil, Madeleine Werhane, Steven P Millard, Eric C Petrie, Brett Parmenter, Sarah Peterson, Scott Sorg, Rebecca Hendrickson, Cindy Mayer, James S Meabon, Bertrand R Huber, Murray Raskind, David G Cook, Elaine R Peskind
OBJECTIVES: To evaluate prospective and retrospective memory abilities in Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) Veterans with and without a self-reported history of blast-related mild traumatic brain injury (mTBI). METHODS: Sixty-one OEF/OIF/OND Veterans, including Veterans with a self-reported history of blast-related mTBI (mTBI group; n=42) and Veterans without a self-reported history of TBI (control group; n=19) completed the Memory for Intentions Test, a measure of prospective memory (PM), and two measures of retrospective memory (RM), the California Verbal Learning Test-II and the Brief Visuospatial Memory Test-Revised...
April 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29180259/post-operative-cognitive-dysfunction-an-exploration-of-the-inflammatory-hypothesis-and-novel-therapies
#9
REVIEW
David R Skvarc, Michael Berk, Linda K Byrne, Olivia M Dean, Seetal Dodd, Matthew Lewis, Andrew Marriott, Eileen M Moore, Gerwyn Morris, Richard S Page, Laura Gray
Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with significant clinical, social and financial impacts for patients and their communities. The underlying pathophysiology is becoming increasingly understood, with the role of neuroinflammation and oxidative stress secondary to surgery and anaesthesia strongly implicated. This review aims to describe the putative mechanisms by which surgery-induced inflammation produces cognitive sequelae, with a focus on identifying potential novel therapies based upon their ability to modify these pathways...
January 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29157293/effect-of-memantine-on-post-operative-cognitive-dysfunction-after-cardiac-surgeries-a-randomized-clinical-trial
#10
Saba Ghaffary, Padideh Ghaeli, Azita Hajhossein Talasaz, Abbasali Karimi, Maryam Noroozian, Abbas Salehiomran, Arash Jalali
BACKGROUND: Post-operative cognitive dysfunction (POCD) is an important complication of cardiac surgeries. Glutamate plays a critical role in physiologic and pathologic conditions in the brain. Due to the role of glutamate in ischemia, this study is designed to identify the effect of memantine in prevention of POCD early and late after cardiac surgeries. METHODS: In this randomized clinical trial, 172 patients with ages 45-75 years old who underwent elective cardiac surgery were enrolled...
November 21, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/29042297/trek-1-pathway-mediates-isoflurane-induced-memory-impairment-in-middle-aged-mice
#11
Yanhui Cai, Zhengwu Peng, Haiyun Guo, Feng Wang, Yi Zeng
Post-operative cognitive dysfunction (POCD) has been widely reported, especially in elderly patients. An association between POCD and inhalational anesthetics, such as isoflurane, has been suggested. The TWIK-related K(+) channel-1 (TREK-1) controls several major cellular responses involved in memory formation and is believed to participate in the development of depression, cerebral ischemia and blood-brain barrier dysfunction. However, the specific role of TREK-1 in mediating anesthesia-induced POCD remains unknown...
October 16, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28984099/postoperative-delirium-and-postoperative-cognitive-dysfunction-updates-in-pathophysiology-potential-translational-approaches-to-clinical-practice-and-further-research-perspectives
#12
Marco Cascella, Maria R Muzio, Sabrina Bimonte, Arturo Cuomo, Jan G Jakobsson
Postoperative delirium, the onset of confusion/delirium during the early postoperative phase, is the most common postoperative complication in older adults and represents a medical emergency that requires immediate assessment and treatment. On the other hand, the term postoperative cognitive decline or dysfunction refers to a wide spectrum of clinical conditions featuring a decline in a variety of neuropsychological domains including memory, executive functioning, and speed of processing emerging week to months after anesthesia and surgery...
February 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28941093/staging-in-bipolar-disorder-from-theoretical-framework-to-clinical-utility
#13
Michael Berk, Robert Post, Aswin Ratheesh, Emma Gliddon, Ajeet Singh, Eduard Vieta, Andre F Carvalho, Melanie M Ashton, Lesley Berk, Susan M Cotton, Patrick D McGorry, Brisa S Fernandes, Lakshmi N Yatham, Seetal Dodd
Illness staging is widely utilized in several medical disciplines to help predict course or prognosis, and optimize treatment. Staging models in psychiatry in general, and bipolar disorder in particular, depend on the premise that psychopathology moves along a predictable path: an at-risk or latency stage, a prodrome progressing to a first clinical threshold episode, and one or more recurrences with the potential to revert or progress to late or end-stage manifestations. The utility and validity of a staging model for bipolar disorder depend on its linking to clinical outcome, treatment response and neurobiological measures...
October 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/28920038/comparing-the-effect-of-preoperative-administration-of-melatonin-and-passiflora-incarnata-on-postoperative-cognitive-disorders-in-adult-patients-undergoing-elective-surgery
#14
Faranak Rokhtabnak, Mohammad Reza Ghodraty, Alireza Kholdebarin, Ali Khatibi, Seyedeh Somayeh Seyed Alizadeh, Zahra Sadat Koleini, Mohammad Mahdi Zamani, Alireza Pournajafian
BACKGROUND: Anxiety is a preoperative complication, which most patients encounter. The use of a premedication to reduce preoperative anxiety with minimal cognitive impairment is crucial. OBJECTIVES: This study was conducted to compare the sedative effect of preoperative melatonin and Passiflora incarnata in patients undergoing elective surgery regarding their potential for postoperative cognitive disorders. METHODS: In this clinical trial, 52 patients American society of anesthesiologists grade (ASA) I and II of both genders were selected to receive either Passiflora incarnata (1000 mg nature made) (n = 26) or melatonin (6 mg) (n = 26) as premedication one hour before surgery...
February 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28869897/thalidomide-alleviates-postoperative-pain-and-spatial-memory-deficit-in-aged-rats
#15
Peng Guo, Si-Ping Hu
Pain is a major risk factor of post-operative cognitive dysfunction (POCD) in aged population. We investigated the effects of thalidomide, an anti-inflammatory and analgesic drug, on POCD in aged rats, and also explored the underlying mechanisms. Laparotomy was performed under anesthesia in aged rats (24-25 months) to establish POCD models. Thalidomide (5-50mg/kg) was intraperitoneally administered immediately after laparotomy. Within 12h after the operation, pain symptoms were assessed by rat grimace scale (RGS)...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28852014/anesthetic-alterations-of-collective-terahertz-oscillations-in-tubulin-correlate-with-clinical-potency-implications-for-anesthetic-action-and-post-operative-cognitive-dysfunction
#16
Travis J A Craddock, Philip Kurian, Jordane Preto, Kamlesh Sahu, Stuart R Hameroff, Mariusz Klobukowski, Jack A Tuszynski
Anesthesia blocks consciousness and memory while sparing non-conscious brain activities. While the exact mechanisms of anesthetic action are unknown, the Meyer-Overton correlation provides a link between anesthetic potency and solubility in a lipid-like, non-polar medium. Anesthetic action is also related to an anesthetic's hydrophobicity, permanent dipole, and polarizability, and is accepted to occur in lipid-like, non-polar regions within brain proteins. Generally the protein target for anesthetics is assumed to be neuronal membrane receptors and ion channels, however new evidence points to critical effects on intra-neuronal microtubules, a target of interest due to their potential role in post-operative cognitive dysfunction (POCD)...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807062/neuropsychiatric-characteristics-of-antiterrorist-operation-combatants-in-the-donbass-ukraine
#17
Konstantin N Loganovsky, Natalia A Zdanevich, Marina V Gresko, Donatella Marazziti, Tatiana K Loganovskaja
OBJECTIVE: The present paper aimed to explore the neuropsychiatric characteristics of the antiterrorism (ATO) combatants in the Donets Basin (Donbass) and to propose therapeutic strategies for managing their mental healthcare. METHODS: A total of 54 ATO combatants were included in our study and compared with four groups of subjects exposed to other emergencies, including the Chernobyl disaster and the war in Afghanistan. The neuropsychiatric features were assessed through psychopathological assessments, neurological examinations, and quantitative electroencephalography (qEEG)...
August 15, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28745667/-prevention-and-correction-of-cognitive-dysfunction-after-general-anesthesia
#18
RANDOMIZED CONTROLLED TRIAL
A Yu Novikov, V A Kovalev, N V Vinichuk, Yu A Chernyh, I E Golub, L V Sorokina
AIM: To evaluate clinical efficacy of intraoperative use of cytoflavin in the prevention and correction of cognitive functions in surgical patients with no history of neurological and psychosomatic disorders. MATERIAL AND METHODS: The study included 60 female patients who underwent surgery on the thyroid gland. Patients were stratified into two equal groups matched for main indices. Patients of the main group received infusions of cytoflavin (20 ml in 200 ml of 5% glucose solution)...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28743056/apigenin-attenuates-isoflurane-induced-cognitive-dysfunction-via-epigenetic-regulation-and-neuroinflammation-in-aged-rats
#19
Lin Chen, Wenji Xie, Wenqin Xie, Weiqiang Zhuang, Changcheng Jiang, Naizhen Liu
PURPOSE OF THE RESEARCH: Post operational cognitive dysfunction (POCD) occurs in patients after anesthesia and surgery. Abnormal histone acetylation and neuroinflammation are key factors in the pathogenesis of cognitive impairment. Apigenin not only has an anti-inflammatory activity but also modifies histone acetylation. We aimed to investigate whether apigenin can attenuate isoflurane exposure-induced cognitive decline by regulating histone acetylation and inflammatory signaling. MATERIALS AND METHODS: Spatial learning and memory were assessed by Morris water maze test...
July 6, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28697315/an-update-on-anesthetics-and-impact-on-the-brain
#20
REVIEW
Vincenzo Fodale, Vincenzo F Tripodi, Olivia Penna, Fausto Famà, Francesco Squadrito, Epifanio Mondello, Antonio David
While anesthetics are indispensable clinical tools and generally considered safe and effective, a growing concern over the potential neurotoxicity of anesthesia or specific anesthetic agents has called into question the safety of general anesthetics, especially when administered at extremes of age. Areas covered: This article reviews and updates research findings on the safety of anesthesia and anesthetics in terms of long-term neurotoxicity, with particular focus on postoperative cognitive dysfunctions, Alzheimer's disease and dementias, developing brain, post-operative depression and autism spectrum disorder...
September 2017: Expert Opinion on Drug Safety
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