Yuan Chen, Yi Zhou, Jinhan Cai, Jiayi Xu, Chenwei Hu, Huiyue Chen, Yirui Hong, Nanyi Pan, Yujie Jiang, Chenhui Zhou, Hua Wei, Zhipeng Xu, Lin Liu, Xiang Wu, Wei Cui
Post-operative cognitive dysfunction (POCD) is a multi-etiological symptom mainly occurred in elderly people after surgery. The activation of retinoic acid receptor α (RARα), a transcriptional factor, was previously predicated to be negatively associated with the occurrence of POCD. However, the mechanisms underlying anti-POCD effects of RARα were still unclear. In this study, AM580, a selective agonist of RARα, and all-trans-retinoic acid (ATRA), a pan agonist of RAR, significantly alleviated cognitive dysfunction and increased the expression of RARα in elderly mice after surgery, which was decreased by RO41-5253, an antagonist of RARα...
March 2, 2024: International Immunopharmacology