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Post operative cognitive dysfunction

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https://www.readbyqxmd.com/read/28224377/curcumin-attenuates-surgery-induced-cognitive-dysfunction-in-aged-mice
#1
Xiang Wu, Huixin Chen, Chunhui Huang, Xinmei Gu, Jialing Wang, Dilin Xu, Xin Yu, Chu Shuai, Liping Chen, Shun Li, Yiguo Xu, Tao Gao, Mingrui Ye, Wei Su, Haixiong Liu, Jinrong Zhang, Chuang Wang, Junping Chen, Qinwen Wang, Wei Cui
Post-operative cognitive dysfunction (POCD) is associated with elderly patients undergoing surgery. However, pharmacological treatments for POCD are limited. In this study, we found that curcumin, an active compound derived from Curcuma longa, ameliorated the cognitive dysfunction following abdominal surgery in aged mice. Further, curcumin prevented surgery-induced anti-oxidant enzyme activity. Curcumin also increased brain-derived neurotrophic factor (BDNF)-positive area and expression of pAkt in the brain, suggesting that curcumin activated BDNF signaling in aged mice...
February 21, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28217289/peripheral-surgical-wounding-may-induce-cognitive-impairment-through-interlukin-6-dependent-mechanisms-in-aged-mice
#2
Yuanlin Dong, Zhipeng Xu, Lining Huang, Yiying Zhang, Zhongcong Xie
Post-operative cognitive dysfunction (POCD) is associated with morbidity, mortality and increased cost of medical care. However, the neuropathogenesis and targeted interventions of POCD remain largely to be determined. We have found that the peripheral surgical wounding induces an age-dependent Aβ accumulation, neuroinflammation and cognitive impairment in aged mice. Pro-inflammatory cytokine interlukin-6 (IL-6) has been reported to be associated with cognitive impairment in rodents and humans. However, the role of IL-6 in the neuropathogenesis of POCD is unknown...
October 2016: Medical Gas Research
https://www.readbyqxmd.com/read/28063267/diabetes-glycemia-and-risk-of-post-operative-cognitive-dysfunction-a-meta-analysis
#3
I Feinkohl, G Winterer, T Pischon
BACKGROUND: Post-operative cognitive dysfunction (POCD) occurs frequently after surgery, particularly among older people. Diabetes, chronic hyperglycemia and a history of hypoglycemia are related to cognitive impairment, but little is known about their roles in POCD. Here, we estimated their associations with risk of POCD on the basis of published epidemiological research. METHODS: The PubMed and Cochrane databases were searched for longitudinal studies of adults undergoing surgery with reporting of associations of diabetes status, glycemic levels and/or a history of hypoglycemia with risk of POCD as relative risks or odds ratios...
January 7, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28048971/insulin-resistance-plays-a-potential-role-in-postoperative-cognitive-dysfunction-in-patients-following-cardiac-valve-surgery
#4
Ni Tang, Rongrong Jiang, Xiaobin Wang, Jian Wen, Li Liu, Jiali Wu, Chunxiang Zhang
Severe insulin resistance(IR) promotes the development of Alzheimer disease. IR and postoperative cognitive dysfunction (POCD) are a common complication during the cardiac perioperative period. The authors hypothesized that IR of individuals with cardiac valve surgery would have increased the risk of POCD. The purpose of the study was to analyze the association of IR and POCD after cardiac valve surgery. Total 131 patients who underwent valve replacement via cardiopulmonary bypass(CPB) were included. Cognitive function was assessed by a series of neuropsychological measurements at 1 day before and 7 days after the surgery...
December 31, 2016: Brain Research
https://www.readbyqxmd.com/read/27903334/applying-an-evidence-based-assessment-model-to-identify-students-at-risk-for-perceived-academic-problems-following-concussion
#5
Danielle M Ransom, Alison R Burns, Eric A Youngstrom, Christopher G Vaughan, Maegan D Sady, Gerard A Gioia
OBJECTIVES: The aim of this study was to demonstrate the utility of an evidence-based assessment (EBA) model to establish a multimodal set of tools for identifying students at risk for perceived post-injury academic problems. METHODS: Participants included 142 students diagnosed with concussion (age: M=14.95; SD=1.80; 59% male), evaluated within 4 weeks of injury (median=16 days). Demographics, pre-injury history, self- and parent-report measures assessing symptom severity and executive functions, and cognitive test performance were examined as predictors of self-reported post-injury academic problems...
November 2016: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/27807966/analysis-of-cerebral-glucose-metabolism-in-patients-with-post-operative-cognitive-dysfunction
#6
Jan M Herter, Niko Brenscheid, Lydia Nienhaus, Charlotte Dieterich, Matthias Weckesser, Hugo VAN Aken
No abstract text is available yet for this article.
November 3, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27789263/postoperative-cerebral-dysfunction-in-the-elderly-diagnosis-and-prophylaxis
#7
D Benhamou, A Brouquet
Post-operative cerebral dysfunction includes delirium, usually occurring early and reversible, and post-operative cognitive disorders, usually occurring later and prolonged. This is a frequent complication in patients older than 75 years old. The two neurological pictures are often inter-related. The pathophysiology of both entities is similar and related to post-operative neuro-inflammation; therefore onset may occur independently of any surgical complication. Post-operative cerebral dysfunction is a serious organic complication...
December 2016: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/27738502/chronic-persistent-post-surgical-pain-following-staging-laparotomy-for-carcinoma-of-ovary-and-its-relationship-to-signal-transduction-genes
#8
Ashok Kumar Saxena, Geetanjali T Chilkoti, Anand K Chopra, Basu Dev Banerjee, Tusha Sharma
BACKGROUND: The present study was undertaken to evaluate the incidence of chronic persistent post-surgical pain (CPPP) and the role of signal transduction genes in patients undergoing staging laparotomy for carcinoma ovary. METHODS: The present observational study was undertaken following institutional ethical committee approval and informed consent from all the participants. A total 21 patients of ASA grade I to III with age 20-70 years, scheduled for elective staging laparotomy for carcinoma ovary were included...
October 2016: Korean Journal of Pain
https://www.readbyqxmd.com/read/27729858/disrupted-interhemispheric-synchrony-in-default-mode-network-underlying-the-impairment-of-cognitive-flexibility-in-late-onset-depression
#9
Zhenghua Hou, Yuxiu Sui, Xiaopeng Song, Yonggui Yuan
The intuitive association between cognitive impairment and aberrant functional activity in the brain network has prompted interest in exploring the role of functional connectivity in late-onset depression (LOD). The relationship of altered voxel-mirrored homotopic connectivity (VMHC) and cognitive dysfunction in LOD is not yet well understood. This study was designed to examine the implicit relationship between the disruption of interhemispheric functional coordination and cognitive impairment in LOD. LOD patients (N = 31) and matched healthy controls (HCs; N = 37) underwent neuropsychological tests and functional magnetic resonance imaging (fMRI) in this study...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27717957/early-post-surgical-cognitive-dysfunction-is-a-risk-factor-for-mortality-among-hip-fracture-hospitalized-older-persons
#10
C Ruggiero, L Bonamassa, L Pelini, I Prioletta, L Cianferotti, A Metozzi, E Benvenuti, G Brandi, A Guazzini, G C Santoro, P Mecocci, D Black, M L Brandi
: This study investigates the relationship between cognitive dysfunction or delirium detected in the early post-surgical phase and the 1-year mortality among 514 hip fracture hospitalized older persons. Patients with early cognitive dysfunction or delirium experienced a 2-fold increased mortality risk. Early post-operative cognitive dysfunction and delirium are negative prognostic factors for mortality. BACKGROUND AND PURPOSE: Premorbid cognitive impairment and dementia in older individuals negatively affect functional recovery after hip fracture...
October 7, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27600013/-incidence-of-the-post-operative-cognitive-dysfunction-in-elderly-patients-with-general-anesthesia-combined-with-epidural-anesthesia-and-patient-controlled-epidural-analgesia
#11
Yan Wang, Xiaohua Liu, Haiying Li
OBJECTIVE: To explore the effect of general anesthesia combined with epidural anesthesia and patient-controlled epidural analgesia on the incidence of the post-operative cognitive dysfunction (POCD) in elderly patients.
 METHODS: A total of 100 elderly patients with gastric cancer, who underwent radical gastrectomy in Yan'an People's Hospital from March 2012 to March 2015, were randomly divided into 3 groups: a general anesthesia and patient-controlled intravenous analgesia (PCIA) (Group I, n=35), a general anesthesia combined with epidural anesthesia and PCIA (Group II, n=30), and a general anesthesia combined with epidural anesthesia and patient-controlled epidural analgesia (PCEA) (Group III, n=35)...
August 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27578364/no-convincing-association-between-post-operative-delirium-and-post-operative-cognitive-dysfunction-a-secondary-analysis
#12
M Franck, K Nerlich, B Neuner, P Schlattmann, W R Brockhaus, C D Spies, F M Radtke
BACKGROUND: Post-operative delirium and post-operative cognitive dysfunction (POCD) are both common but it has not been clarified how closely they are associated. We aimed to assess the possible relationship in a secondary analysis of data from the 'Surgery Depth of anaesthesia and Cognitive outcome'- study. METHODS: We included patients aged ≥ 60 years undergoing non-cardiac surgery planned for longer than 60 min. Delirium was assessed according to the Diagnostic and Statistical Manual of Mental Disorders IV criteria in the post-anaesthesia care unit (PACU) as well as within the first week after surgery...
November 2016: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27530591/risk-factors-for-the-development-of-post-operative-cognitive-dysfunction
#13
Maria D Pappa, Nikolaos V Theodosiadis, Andreas Tsounis, Pavlos Sarafis
BACKGROUND: Many studies have shown that a large number of patients undergoing surgery show a measurable cognitive deterioration after surgery, while many of them still show cognitive deficits even three months later an operation. These specific cognitive deficits in which there is a temporal association between surgery and mental disorders are defined as postoperative impairment of cognitive function. Among cognitive disorders occurring during the postoperative period, the post-operative cognitive dysfunction (POCD) is less studied...
2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27320248/association-of-ct-perfusion-and-postoperative-cognitive-dysfunction-after-off-pump-coronary-artery-bypass-grafting
#14
Zhe Song, Paul Fu, Mingying Chen, Qi Bi
OBJECTIVE: To investigate the relationship between an abnormal CT perfusion scan and postoperative cognitive dysfunction, as measured by changes in MoCA and MMSE scores, after off-pump coronary artery bypass grafting (OPCABG). METHODS: Eight hundred and thirteen patients were selected who underwent OPCABG between August 2010 and September 2013. Cognitive function was assessed before operation and at seven days post-op. CT perfusion scan was obtained preoperatively and was used to divide patients into two groups: abnormal perfusion and normal perfusion groups...
June 2016: Neurological Research
https://www.readbyqxmd.com/read/27222065/electroacupuncture-ameliorates-propofol-induced-cognitive-impairment-via-an-opioid-receptor-independent-mechanism
#15
Yan Liu, Xin-Juan Wang, Na Wang, Cai-Lian Cui, Liu-Zhen Wu
While general anesthesia is known to induce cognitive deficits in elderly and pediatric patients, its influence on adults is less well-characterized. The present study was designed to evaluate the influence of propofol on the learning and memory of young adult rats, as well as the potential neuroprotective role of electroacupuncture (EA) in propofol-induced cognitive impairment. Intravenous anesthesia with propofol was administered to young adult male Sprague-Dawley (SD) rats for 6 h, and EA was administered three times before and after anesthesia...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27145889/pre-existing-cognitive-impairment-and-post-operative-cognitive-dysfunction-should-we-be-talking-the-same-language
#16
Lisbeth Evered, Brendan Silbert, David A Scott
Changes in cognition are known to follow anesthesia and surgery in older individuals (Evered et al., 2011). Although survival per se was the prime outcome in the 19th and early 20th centuries for invasive procedures, a link was none-the-less observed with adverse cognitive outcomes as far back as 1887 (Savage, 1887). Historical reports of "insanity" or "weak mindedness" after anesthesia appeared within 40 years of the first anesthetic having been administered and anecdotal and retrospective reports have implicated anesthesia ever since...
July 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27098125/regional-versus-general-anaesthesia-in-elderly-patients-undergoing-surgery-for-hip-fracture-protocol-for-a-systematic-review
#17
COMPARATIVE STUDY
Joyce Yeung, Vanisha Patel, Rita Champaneria, Janine Dretzke
BACKGROUND: With an ageing population, the incidence of hip fractures requiring surgery is increasing. Post-operative delirium is common following hip fracture surgery. Delirium is associated with high mortality and morbidity, poor long-term functional outcomes and institutionalisation. There is some evidence to suggest that perioperative intervention, specifically the anaesthetic technique employed, may reduce the incidence of delirium in this population. The aim of this systematic review is to investigate the impact of anaesthesia type on post-operative delirium...
April 21, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27061744/minocycline-attenuates-post-operative-cognitive-impairment-in-aged-mice-by-inhibiting-microglia-activation
#18
Hui-Lin Wang, Hua Liu, Zhang-Gang Xue, Qing-Wu Liao, Hao Fang
Although it is known that isoflurane exposure or surgery leads to post-operative cognitive dysfunction in aged rodents, there are few clinical interventions and treatments available to prevent this disorder. Minocycline (MINO) produces neuroprotection from several neurodegenerative diseases and various experimental animal models. Therefore, we set out to investigate the effects of MINO pre-treatment on isoflurane or surgery induced cognitive impairment in aged mice by assessing the hippocampal-dependent spatial memory performance using the Morris water maze task...
September 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27027720/post-operative-cognitive-dysfunction-at-3-months-in-adults-after-non-cardiac-surgery-a-qualitative-systematic-review
#19
REVIEW
S Paredes, L Cortínez, V Contreras, B Silbert
BACKGROUND: Post-operative cognitive dysfunction is defined as a decline in cognitive functions that occurs after surgery, but different diagnostic criteria and incidences have been reported in medical literature. Our aim was to determine incidence of post-operative cognitive dysfunction 3 months after non-cardiac surgery in adults. METHODS: A systematic review of available evidence was performed by PRISMA guidelines. A search was done in May-July 2015 on PubMed, EMBASE, CINAHL, LILACS, Scielo, Clinical Trials, and Grey Literature Reports...
September 2016: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27000237/selective-impairment-of-attention-networks-during-propofol-anesthesia-after-gynecological-surgery-in-middle-aged-women
#20
Chen Chen, Guang-hong Xu, Yuan-hai Li, Wei-xiang Tang, Kai Wang
BACKGROUND: Postoperative cognitive dysfunction is a common complication of anesthesia and surgery. Attention networks are essential components of cognitive function and are subject to impairment after anesthesia and surgery. It is not known whether such impairment represents a global attention deficit or relates to a specific attention network. We used an Attention Network Task (ANT) to examine the efficiency of the alerting, orienting, and executive control attention networks in middle-aged women (40-60 years) undergoing gynecologic surgery...
April 15, 2016: Journal of the Neurological Sciences
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