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JOURNAL ARTICLE
Eva Blake, Hannan A Maqsood, Jacob M Dougherty, Gary Vercruysse, Stewart C Wang, Mark R Hemmila, Naveen F Sangji
Electrical burn injuries can be catastrophic, threatening severe disability or mortality. We present a patient who suffered from electrical shock, requiring bilateral above knee amputations, right trans-radial amputation, renal replacement therapy, and veno-arterial extracorporeal life support (VA ECLS) therapy. While there exist reports of cases that have demonstrated the potential use of ECLS in burn patients with cardiogenic shock or acute respiratory distress syndrome (ARDS), this is a unique case of VA ECLS use for an electrical injury patient who developed mixed distributive-obstructive shock secondary to pulmonary embolism and sepsis...
April 22, 2024: Journal of Burn Care & Research: Official Publication of the American Burn Association
#2
REVIEW
Purvi Pravinchandra Patel, Tanya Egodage
Acute kidney injury (AKI) is one of the most common organ dysfunctions impacting ICU (intensive care unit) patients. Early diagnosis using the various classification systems and interventions that can be aided by use of biomarkers are key in improving outcomes. Once the patient meets criteria of AKI, many patient specific factors determine the optimal timing for and mode of renal replacement therapy. There are several special considerations in surgical ICU patients with AKI including management of intracranial hypertension in those with cerebral edema, anticoagulation in high-risk bleeding patients, and use of contrast imaging...
2024: Trauma Surgery & Acute Care Open
#3
JOURNAL ARTICLE
Shalini Santhakumaran, Louis Fisher, Bang Zheng, Viyaasan Mahalingasivam, Lucy Plumb, Edward Pk Parker, Retha Steenkamp, Caroline Morton, Amir Mehrkar, Sebastian Bacon, Sue Lyon, Rob Konstant-Hambling, Ben Goldacre, Brian MacKenna, Laurie A Tomlinson, Dorothea Nitsch
OBJECTIVE: To validate primary and secondary care codes in electronic health records to identify people receiving chronic kidney replacement therapy based on gold standard registry data. DESIGN: Validation study using data from OpenSAFELY and the UK Renal Registry, with the approval of NHS England. SETTING: Primary and secondary care electronic health records from people registered at 45% of general practices in England on 1 January 2020, linked to data from the UK Renal Registry (UKRR) within the OpenSAFELY-TPP platform, part of the NHS England OpenSAFELY covid-19 service...
2024: BMJ Med
#4
JOURNAL ARTICLE
Maria Cristina Ruffa, Giacomo Bignante, Vittorio Bocciero, Sergio Fabbri, Dario Degl'Innocenti, Valentina Cauda, Gianluca Villa
Patients in intensive care are exposed to the risk of microparticle infusion via extracorporeal lines and the resulting complications. A possible source of microparticle release could be the extracorporeal circuit used in blood purification techniques, such as continuous renal replacement therapy (CRRT). Disposable components of CRRT circuits, such as replacement bags and circuit tubing, might release microparticles such as salt crystals produced by precipitation in replacement bags and plastic microparticles produced by spallation...
April 20, 2024: Scientific Reports
#5
JOURNAL ARTICLE
Ammar Abdulrahman Jairoun, Chong Chee Ping, Baharudin Ibrahim
Predicting the course of kidney disease in individuals with both type 1 and type 2 diabetes mellitus (DM) is a significant clinical and policy challenge. In several regions, DM is now the leading cause of end-stage renal disease. The aim of this study to identify both modifiable and non-modifiable risk factors, along with clinical markers and coexisting conditions, that increase the likelihood of stage 3-5 chronic kidney disease (CKD) development in individuals with type 2 DM in the United Arab Emirates (UAE)...
April 19, 2024: Scientific Reports
#6
JOURNAL ARTICLE
Rudolph A Rodriguez, Matthew A Sparks, Paul T Conway, Anamika Gavhane, Siddharta Reddy, Linda Awdishu, Sana Waheed, Sandra Davidson, Deborah B Adey, Janice P Lea, John C Lieske, Furman S McDonald
In 1988, the American Board of Internal Medicine (ABIM) defined essential procedural skills in nephrology, and candidates for ABIM certification were required to present evidence of possessing the skills necessary for placement of temporary dialysis vascular access, hemodialysis, peritoneal dialysis, and percutaneous renal biopsy. In 1996, continuous renal replacement therapy was added to the list of nephrology requirements. These procedure requirements have not been modified since 1996 while the practice of nephrology has changed dramatically...
April 17, 2024: American Journal of Kidney Diseases
#7
REVIEW
Olga Balafa, Beatriz Fernandez-Fernandez, Alberto Ortiz, Evangelia Dounousi, Robert Ekart, Charles J Ferro, Patrick B Mark, Jose M Valdivielso, Lucia Del Vecchio, Francesca Mallamaci
Sex (biologically determined) and gender (socially constructed) modulate manifestations and prognosis of a vast number of diseases, including cardiovascular disease (CVD) and chronic kidney disease (CKD). CVD remains the leading cause of death in CKD patients. Population-based studies indicate that women present a higher prevalence of CKD and experience less CVD than men in all CKD stages, although this is not as clear in patients on dialysis or transplantation. When compared to the general population of the same sex, CKD has a more negative impact on women on kidney replacement therapy...
March 2024: Clinical Kidney Journal
#8
JOURNAL ARTICLE
Brittany A Boerstra, Rianne Boenink, Megan E Astley, Marjolein Bonthuis, Samar Abd ElHafeez, Federico Arribas Monzón, Anders Åsberg, Pazit Beckerman, Samira Bell, Aleix Cases Amenós, Pablo Castro de la Nuez, Marc A G J Ten Dam, Alicja Debska-Slizien, Nikola Gjorgjievski, Rebecca Giudotti, Jaakko Helve, Kristine Hommel, Alma Idrizi, Ólafur S Indriðason, Faiçal Jarraya, Julia Kerschbaum, Kirill S Komissarov, Nadiia Kozliuk, Milica Kravljaca, Mathilde Lassalle, Johan M De Meester, Mai Ots-Rosenberg, Zoe Plummer, Danilo Radunovic, Olena Razvazhaieva, Halima Resic, Olga Lucía Rodríguez Arévalo, Carmen Santiuste de Pablos, Nurhan Seyahi, María Fernanda Slon-Roblero, Maria Stendahl, Miloreta Tolaj-Avdiu, Sara Trujillo-Alemán, Ieva Ziedina, Edita Ziginskiene, Alberto Ortiz, Kitty J Jager, Vianda S Stel, Anneke Kramer
BACKGROUND: The European Renal Association (ERA) Registry collects data on kidney replacement therapy (KRT) in patients with end-stage kidney disease (ESKD). This paper is a summary of the ERA Registry Annual Report 2021, including a comparison across treatment modalities. METHODS: Data was collected from 54 national and regional registries from 36 countries, of which 35 registries from 18 countries contributed individual patient data and 19 registries from 19 countries contributed aggregated data...
February 2024: Clinical Kidney Journal
#9
JOURNAL ARTICLE
Ah Young Leem, Soyul Han, Kyung Soo Chung, Su Hwan Lee, Moo Suk Park, Bora Lee, Young Sam Kim
BACKGROUND/AIMS: Intensive care unit (ICU) quality is largely determined by the mortality rate. Therefore, we aimed to develop and validate a novel prognostic model for predicting mortality in Korean ICUs, using national insurance claims data. METHODS: Data were obtained from the health insurance claims database maintained by the Health Insurance Review and Assessment Service of South Korea. From patients who underwent the third ICU adequacy evaluation, 42,489 cases were enrolled and randomly divided into the derivation and validation cohorts...
April 19, 2024: Korean Journal of Internal Medicine
#10
JOURNAL ARTICLE
Wei Wei, Caihong Liu, Guojiao Song, Letian Yang, Jian Li, Bo Wang, Ting Yin, Yingying Yang, Liang Ma, Ling Zhang, Ping Fu, Yuliang Zhao
BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR) has been suggested to be a prognostic marker for various diseases, but whether NLR dynamics (ΔNLR) is related to mortality and disease severity in patients with septic acute kidney injury (AKI) has not been determined. METHODS: Between August 2013 and August 2021, septic AKI patients at our center were retrospectively enrolled. ΔNLR was defined as the difference between the NLR at septic AKI diagnosis and at hospital admission...
December 2024: Renal Failure
#11
JOURNAL ARTICLE
Christina G Hutten, Kishan Padalia, Alexi Vasbinder, Yiyuan Huang, Anis Ismail, Ian Pizzo, Kristen Machado Diaz, Tonimarie Catalan, Feriel Presswalla, Elizabeth Anderson, Grace Erne, Brayden Bitterman, Pennelope Blakely, Evangelos J Giamarellos-Bourboulis, Sven H Loosen, Frank Tacke, Athanasios Chalkias, Jochen Reiser, Jesper Eugen-Olsen, Mousumi Banerjee, Rodica Pop-Busui, Salim S Hayek
CONTEXT: Obesity is a risk factor for coronavirus disease 2019 (COVID-19)-related outcomes; however, the mechanism remains unclear. OBJECTIVE: The objective of this analysis was to determine whether inflammation mediates the association between obesity and COVID-19 outcomes. DESIGN: The International Study of Inflammation in Covid-19 (ISIC): A Prospective Multi-Center Observational Study Examining the Role of Biomarkers of Inflammation in Predicting Covid-19 Related Outcomes in Hospitalized Patients...
April 18, 2024: Journal of Clinical Endocrinology and Metabolism
#12
JOURNAL ARTICLE
Takuya Taira, Akihiko Inoue, Hiroshi Okamoto, Kunihiko Maekawa, Toru Hifumi, Tetsuya Sakamoto, Yasuhiro Kuroda, Masafumi Suga, Takeshi Nishimura, Shinichi Ijuin, Satoshi Ishihara
OBJECTIVE: The association between fluid balance and outcomes in patients who underwent out-of-hospital cardiac arrest (OHCA) and received extracorporeal cardiopulmonary resuscitation (ECPR) remains unknown. We aimed to examine the above relationship during the first 24 h following intensive care unit (ICU) admission. METHODS: We performed a secondary analysis of the SAVE-J II study, a retrospective multicenter study involving OHCA patients aged ≥ 18 years treated with ECPR between 2013 and 2018 and who received fluid therapy following ICU admission...
April 18, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
#13
JOURNAL ARTICLE
I Vaněčková, J Zicha
A new class of antidiabetic drugs - gliflozins (inhibitors of sodium glucose cotransporter-2; SGLT-2i) stimulate glucose and sodium excretion, thereby contributing to improved glycemic control, weight loss and blood pressure reduction in diabetic patients. Large clinical trials in patients with type 2 diabetes treated with empagliflozin, canagliflozin or dapagliflozin have demonstrated their excellent efficacy in improving many cardiovascular outcomes, including the reduction of death from cardiovascular diseases, non-fatal myocardial infarction or stroke, and hospitalization for heart failure...
April 18, 2024: Physiological Research
#14
JOURNAL ARTICLE
Gema Ariceta, Fernando Santos, Andrés López Muñiz, Alvaro Hermida, Maria Luisa Matoses, Ana Ventura, Paloma Leticia Martin-Moreno, Esther González, Laura Acuña, Elisa Giner, Julia Vara
BACKGROUND: The purpose of this study is to evaluate the effectiveness and safety of switching from immediate-release (IR) to extended-release (ER) cysteamine in patients with nephropathic cystinosis (NC) in Spain. METHODS: We conducted an observational, retrospective, multicentre study in NC patients who received IR cysteamine for at least 12 months, switched to ER cysteamine, and received it for at least 6 months before inclusion. RESULTS: Data were collected from nine patients (four children, five adults) 36 months before and after the switch...
April 2024: Clinical Kidney Journal
#15
Masahiro Okabe, Nobuo Tsuboi, Hiroyuki Ueda, Erika Hishida, Yoichi Miyazaki, Takashi Yokoo
Immunoglobulin A nephropathy (IgAN) is characterized by diverse clinicopathological phenotypes. Herein we present a follow-up study of previously reported identical twin sisters with IgAN. The older sister exhibited more severe kidney histopathology and proteinuria and a lower birthweight than did her younger sister, and only the older sister experienced two childbirths. These raised concerns regarding her kidney outcomes. However, with timely multidisciplinary treatments, the older sister's kidney function remained preserved after 20 years of IgAN history...
April 2024: Clinical Kidney Journal
#16
REVIEW
Smitesh Padte, Vikramaditya Samala Venkata, Priyal Mehta, Sawsan Tawfeeq, Rahul Kashyap, Salim Surani
Critical care medicine in the 21st century has witnessed remarkable advancements that have significantly improved patient outcomes in intensive care units (ICUs). This abstract provides a concise summary of the latest developments in critical care, highlighting key areas of innovation. Recent advancements in critical care include Precision Medicine: Tailoring treatments based on individual patient characteristics, genomics, and biomarkers to enhance the effectiveness of therapies. The objective is to describe the recent advancements in Critical Care Medicine...
March 9, 2024: World Journal of Critical Care Medicine
#17
JOURNAL ARTICLE
Helena I Kurniawan, Kelly O'Malley, Renée Santana, Jeff Kowaleski, Lara M Skarf
Guidelines are lacking for patients with calciphylaxis on renal replacement therapy, often leading to difficulty optimally treating these patients. A 60-year-old male veteran receiving hemodialysis presented with calciphylaxis of the left lower extremity and intractable pain. His condition was complicated by chronic back pain, long-term opioid therapy, and psychological trauma history. He was ultimately transferred to a calciphylaxis treatment center but was unable to tolerate further treatments due to sepsis and hemodynamic instability...
April 17, 2024: Journal of Palliative Medicine
#18
EDITORIAL
Kate I Stevens, Francesca Mallamaci, Alberto Ortiz, Jordi Bover, Pierre Delanaye, Roser Torra, Mario Cozzolino
No abstract text is available yet for this article.
April 2024: Clinical Kidney Journal
#19
JOURNAL ARTICLE
Kyle C White, Kevin B Laupland, Marlies Ostermann, Ary Serpa Neto, Michelle L Gatton, Rod Hurford, Pierre Clement, Barnaby Sanderson, Rinaldo Bellomo
Introduction In critically ill patients undergoing continuous renal replacement therapy (CRRT), a positive fluid balance (FB) is associated with adverse outcomes. However, current FB management practices in CRRT patients are poorly understood. We aimed to study FB and its components in British and Australian CRRT patients to inform future trials. Methods We obtained detailed electronic health record data on all fluid-related variables during CRRT and hourly FB for the first seven days of treatment. Results We studied 1,616 patients from three tertiary ICUs in two countries...
April 16, 2024: Blood Purification
#20
JOURNAL ARTICLE
Abdallah Damin Abukhalil, Haya Alyazouri, Reem Alsheikh, Hadeel Kahla, Minna Mousa, Hosniyeh Ladadweh, Ni'meh Al-Shami, Yousef Sahoury, Hani Naseef, Abdullah Rabba
BACKGROUND: Acute kidney injury (AKI) is a major medical problem affecting patients' quality of life and healthcare costs. OBJECTIVES: This study evaluated the severity, risk factors, and outcomes of patients diagnosed with acute kidney injury (AKI), including community-acquired AKI (CA-AKI) and hospital-acquired AKI (HA-AKI), who were admitted to tertiary institutions in Palestine. METHODS: This retrospective cross-sectional study was conducted at multiple tertiary care hospitals in Palestine by reviewing patient charts from January 2020 to March 2023...
2024: TheScientificWorldJournal
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