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https://www.readbyqxmd.com/read/29917287/new-drugs-and-regimens-for-tuberculosis
#1
REVIEW
Kwok-Chiu Chang, Eric Nuermberger, Giovanni Sotgiu, Chi-Chiu Leung
Since standardized rifampin-based first-line regimens and fluoroquinolone-based second-line regimens were used to treat tuberculosis (TB), unfortunately without timely modification according to the drug resistance profile, TB and drug-resistant disease are still important public health threats worldwide. Although the last decade has witnessed advances in rapid diagnostic tools and use of repurposed and novel drugs for better managing drug-resistant TB, we need an appropriate TB control strategy and a well-functioning health infrastructure to ensure optimal operational use of rapid tests, judicious use of effective treatment regimens that can be rapidly tailored according to the drug resistance profile and timely management of risk factors and co-morbidities that promote infection and its progression to disease...
June 19, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29917228/title-reduced-blood-volume-decreases-cerebral-blood-flow-in-preterm-piglets
#2
Yvonne A Eiby, Nicole Y Shrimpton, Ian M R Wright, Eugenie R Lumbers, Paul B Colditz, Greg J Duncombe, Barbara E Lingwood
Preterm infants often have impaired cardiovascular function that may contribute to poor neurodevelopmental outcomes. The study aimed to determine the effects of reduced blood volume on cardiovascular function, including cerebral blood flow in preterm and term piglets. In preterm (97/115d) and term piglets, up to 10% of the estimated blood volume was removed. Removal of blood was ceased if MAP dropped below 20 mmHg. Heart rate, cardiac contractility and relaxation, cardiac output, mean arterial pressure (MAP), and cerebral blood flow were measured at baseline and again after blood volume reduction...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29917008/mid-term-and-long-term-functional-and-radiographic-results-of-13-surgically-treated-adolescent-capitellum-fractures
#3
Tolga Onay, Seyit A Gümüştaş, Said E Baykan, Ahmet H Akgülle, Bülent Erol, Kaan S Irgit
BACKGROUND: Capitellum fractures are rare in adolescents, and information in literature is still limited. The purpose of this study was to report the mid-term and long-term functional and radiographic results of 13 surgically treated adolescent capitellum fractures in a level I trauma center. METHODS: This retrospective study included patients aged 10 to 16 years, who underwent surgery for a capitellum fracture and were followed up for at least 12 months. Fractures were classified according to the McKee modification of the Bryan and Morrey classification, and elbow arthritis was classified using the Broberg and Morrey system...
June 18, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29916984/le-fort-ii-osteotomy-and-modified-technique-presentation
#4
Héctor-Omar Malagón-Hidalgo, Roberto Vilchis-López, Diego-Raúl González-Chapa, Richael-Antonio Silva-Suárez, Eugenio García-Cano, José-Luis Lastiri-Barrios, Fernando González-Magaña
INTRODUCTION: The LeFort II osteotomy has a specific number of indications, thus this is true, there is less experience with the technique. The authors present a modification to the technique and extensive step-by-step procedure explanation in order to share their experience for making a safe surgery. MATERIAL AND METHODS: A clinical report is presented of a nonsyndromatic patient with nasomaxillary hypoplasia, in which the authors make an LeFort II osteotomy with circumvestibular, transcaruncular, and "W"-shaped approaches, with minimal scar showing, in order to offer better aesthetic outcomes as well as functional and skeletal...
June 18, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29916935/mortality-after-total-knee-arthroplasty-a-systematic-review-of-incidence-temporal-trends-and-risk-factors
#5
James R Berstock, Andrew D Beswick, José A López-López, Michael R Whitehouse, Ashley W Blom
BACKGROUND: The capacity for total knee arthroplasty to improve pain, quality of life, and functional outcomes is widely recognized. Postoperative mortality is rare but of paramount importance, and needs to be accurately quantified and conveyed to patients in order to support decision-making prior to surgery. The purpose of this study was to determine a contemporary estimate of the risk of mortality following total knee arthroplasty, including the identification of temporal trends, common causes, and modifiable and nonmodifiable risk factors...
June 20, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29916873/function-an-essential-postoperative-outcome-for-older-adults
#6
Thomas N Robinson
No abstract text is available yet for this article.
June 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29916850/sphincter-of-oddi-dysfunction-sphincter-of-oddi-dysfunction-or-discordance-what-is-the-state-of-the-art-in-2018
#7
Jong Jin Hyun, Richard A Kozarek
PURPOSE OF REVIEW: To review important manuscripts published over the previous 2 years relative to sphincter of Oddi dysfunction (SOD). RECENT FINDINGS: The long-term outcomes of the Evaluating Predictors and Interventions of SOD (EPISOD) trial further substantiated results from the initial EPISOD study, reinforcing that neither endoscopic retrograde cholangiopancreatography-manometry nor endoscopic sphincterotomy are appropriate for SOD type III. Pain management in the latter patients has reverted to neuromodulating agents, and recent studies have suggested a role for duloxetine and potentially acupuncture...
June 16, 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29916597/preliminary-report-on-left-ventricular-assist-devices-are-patients-and-caregivers-psychosocial-needs-adequately-addressed
#8
Silvia Rossi Ferrario, Gianluigi Balestroni, Chiara Gattoni, Giovanna Omarini, Pierangela Omarini, Paola Cerutti, Massimo Pistono
OBJECTIVES: Patients implanted with a Left Ventricular Assist Device (LVAD) constitute a new population of chronic heart failure (HF) patients requiring continuous medical support and representing heavy costs - both direct and indirect - for the healthcare system. If there is consensus about the increased survival, the psychosocial outcomes, in terms of psychological wellbeing, behavioral and social functioning of both patients and caregivers, are still unclear. Overall, it is not clear if local health and social services are equipped to support them in their needs...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916563/-digitalisation-and-clinical-care-pathways-in-rehabilitation-medicine-a-possible-integration-from-the-goal-planning-and-the-rehabilitation-programme-design-to-the-evaluation-of-clinical-outcomes
#9
Anna Giardini, Silvia Traversoni, Claudio Garbelli, Anna Lodigiani
OBJECTIVES: In the light of the growing complexity featuring the contemporary world, a future challenge is represented by the maintenance of the humanization of healthcare, along with the necessity of a high specificity personalized treatment, in a growing emergency of lack of resources. Furthermore, the ongoing digital revolution spreading in every productive sector involves the health-care system as well, playing a crucial role for the goals of the specialized care-related prevention-treatment-rehabilitation approach of the Rehabilitation Medicine...
February 2018: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916562/-chronic-patient-and-a-circular-care-related-prevention-treatment-rehabilitation-model
#10
Gianni Giorgi
OBJECTIVES: The increase in the average life expectancy entails elderly and chronic patients as hospital users, often dependents and requiring recurrent hospitalizations. In this framework, an innovative model of care management is essential to ensure appropriateness and sustainability of health services. METHODS: A highly specialized care-related prevention-treatment-rehabilitation approach in which pharmacological, surgical, physical and intellectual disability therapies coexist in a synergistic manner, is the answer to this new emerging need...
February 2018: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916433/health-impact-is-the-invisible-side-of-terrorism
#11
Bidhu K Mohanti
Since 201 4, there is a shift in terror targets, with a 1 72% increase in the deaths of common citizens. India ranks fourth in the global terrorism index. Intelligence, security and counter-terrorism conjointly form the contours of priority for governance and public engagement but the attendant aspects of health system remain neglected. Recurring acts of global terrorism have given rise to unique medical requirements that can be termed as 'terror medicine', geared towards managing health impacts of terrorism and not just a single patient...
September 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/29916354/-analysis-of-the-cochrane-review-cortisteroid-implants-for-chronic-non-infectious-uveitis-cochrane-database-syst-rev-2016-2-cd010469
#12
Inês Leal, David Cordeiro Sousa, João Costa, António Vaz-Carneiro
Non-infectious uveitis is a heterogeneous collection of inflammatory eye diseases and is one of the most important causes of blindness among active adults in developed countries. Inflammation control is crucial in the prevention of ocular structural and functional damage. Regarding acute inflammatory control, corticosteroids are the mainstay of treatment. Several types of intra-ocular corticosteroids have been used with the aim of enhanced efficacy compared to their topical or peri-ocular administration, while minimizing its adverse effects associated with the systemic administration...
May 30, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29916261/pharma-collaboration-for-transparent-medical-information-phactmi-benchmark-study-trends-drivers-success-factors-and-value-of-globalization-in-medical-information
#13
Suzana A Giffin, Richa Shah, Allison Soloff, Anna Markel Vaysman, Jane Oreper, Andrew Gažo, Pooja Gandhi, Ina Shah, Thomas Malieckal, Daniel Boulos, Teresa Flowers, Carolle A Stevens, Michael S Rocco, Aarti S Patel, Dominick Albano
BACKGROUND: Over the past decade, biopharmaceutical companies have been progressively establishing global frameworks across their capabilities. It is well recognized that the Medical Information (MI) department is a key externally facing function that needs to maintain a consistent focus on optimizing its capabilities of addressing product medical inquiries worldwide. METHODS: In the United States, a consortium named Pharma Collaboration for Transparent Medical Information, phactMI, a collaboration of pharmaceutical company MI departments dedicated to supporting health care professionals in their commitment to provide quality patient care, has provided a forum to benchmark and share best practices across the companies...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29916258/body-composition-dietary-and-gustatory-function-assessment-in-people-with-alzheimer-s-disease
#14
Ismael San Mauro Martín, Víctor Paredes Barato, Sara López Oliva, Marta Rodríguez, Luis Collado Yurrita, Maria José Ciudad Cabañas, Sara Sanz Rojo, Licia de la Calle, Elena Ávila Díaz, Yaiza Quevedo Santos, Paloma Elortegui Pascual, Marta Villanueva Nieto, Elena Garicano Vilar
OBJECTIVES: Observe the association of foods habits, body composition, lifestyle habits, and loss of gustatory function with Alzheimer's disease (AD). METHODS: This comparative study enrolled 75 patients with AD (mean age 77.5 years) and 267 healthy volunteers (mean age 73 years). Weight, height, body mass index (BMI), body fat, visceral fat, muscle mass, and waist circumference were measured. Adherence to the Mediterranean diet was measured by the Mediterranean-Diet-Adherence Screener...
January 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29916121/comparative-study-of-visual-dysfunctions-in-6-10-year-old-very-preterm-and-full-term-born-children
#15
Sanaa A Yassin, Amirah J Al-Dawood, Waseem M Al-Zamil, Mohammad A Al-Ghamdi, Zainab N Al-Khudairy
PURPOSE: To compare visual dysfunction between very preterm-born (VPB) children with no retinopathy of prematurity (no-ROP) at 6-10 years of age and age- and sex-matched full-term-born controls. METHODS: This is an observational, prospective study that included 30 children, 6-10 years of age, born ≤ 32 weeks of gestation, with no-ROP, and 30 age- and sex-matched full-term-born controls, conducted from January 2015 until August 2015. All children underwent complete ophthalmic evaluation...
June 18, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29916106/comparison-of-models-for-predicting-quality-of-life-after-surgical-resection-of-hepatocellular-carcinoma-a-prospective-study
#16
Chong-Chi Chiu, King-Teh Lee, Hao-Hsien Lee, Jhi-Joung Wang, Ding-Ping Sun, Chien-Cheng Huang, Hon-Yi Shi
BACKGROUND: The essential issue of internal validity has not been adequately addressed in prediction models such as artificial neural network (ANN), support vector machine (SVM), Gaussian process regression (GPR), and multiple linear regression (MLR) models. METHODS: This prospective study compared the accuracy of these four models in predicting quality of life (QOL) after hepatic resection received by 332 patients with hepatocellular carcinoma (HCC) during 2012-2015...
June 18, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29916056/reverse-shoulder-arthroplasty-the-role-of-physical-therapy-on-the-clinical-outcome-in-the-mid-term-to-long-term-follow-up
#17
Stephan Uschok, Sebastian Herrmann, Stephan Pauly, Carsten Perka, Stefan Greiner
INTRODUCTION: Reverse shoulder arthroplasty shifts the rotational center of the shoulder joint caudally and medially to restore shoulder function in a rotator cuff deficient shoulder. Despite promising results in early- and mid-term follow-up, long-term loss in shoulder function has been described in the literature. A lack of exercise in elderly patients may be one reason for this loss in function. This study examines the functional benefits of physical therapy in the mid-term to long-term follow-up regarding the subjective and objective shoulder function...
June 19, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29916003/comparison-of-the-outcomes-of-navigation-assisted-revision-of-unicompartmental-knee-arthroplasty-to-total-knee-arthroplasty-versus-navigation-assisted-primary-tka
#18
Han-Jun Lee, Yong-Beom Park, Min-Ku Song, Yoon-Ho Kwak, Seong Hwan Kim
PURPOSE: Revision of unicompartmental knee arthroplasty (UKA) to total knee arthroplasty (TKA) is technically demanding but can be performed with computer navigation system guidance. The purpose of this study was (1) to compare the outcomes of revision of UKA to TKA to those of primary TKA and (2) to describe a surgical technique for the revision of UKA to TKA using a navigation system. METHODS: From May 2011 to April 2014, a total of 298 knees underwent primary navigation-assisted TKA (group 1), and navigation-assisted UKA revision to TKA was performed in 15 patients (group 2)...
June 19, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29915979/trials-with-patient-reported-outcomes-registered-on-the-australian-new-zealand-clinical-trials-registry-anzctr
#19
Rebecca Mercieca-Bebber, Douglas Williams, Margaret-Ann Tait, Jessica Roydhouse, Lucy Busija, Chindhu Shunmuga Sundaram, Michelle Wilson, Ailsa Langford, Claudia Rutherford, Natasha Roberts, Madeleine King, Elisabeth Vodicka, Beth Devine
AIMS: It is important to understand the number, types and regions of trials that include patient-reported outcomes (PROs) to appreciate how patient experiences have been considered in studies of health and interventions. Twenty-seven percent of trials registered with ClinicalTrials.gov (2007-2013) included PROs; however, a regional breakdown was not provided and no reviews have been conducted of the Australia New Zealand Clinical Trials Registry (ANZCTR). We aimed to identify trials registered with ANZCTR with PRO endpoints and describe their characteristics...
June 18, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29915938/-state-of-the-art-of-quality-of-life-measurement-in-patients-with-chronic-otitis-media-and-conductive-hearing-loss
#20
REVIEW
S Lailach, I Baumann, T Zahnert, M Neudert
The evaluation of results after middle ear reconstruction has been mainly based on functional parameters. In clinical practice as well as in otological research, the pure tone audiogram represents the gold standard in the assessment of the postoperative outcome. In order to assess the patient's subjective outcome, outcome analyzes focus increasingly on the health-related quality of life (HRQOL). However, the evaluation of HRQOL requires reliable and validated measuring instruments. A modest number of validated questionnaires for determination of the disease-specific HRQOL in patients with chronic otitis media and/or conductive hearing loss are currently available...
June 18, 2018: HNO
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