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https://www.readbyqxmd.com/read/28809388/dramatic-increase-in-incidence-of-ulcerative-colitis-and-crohn-s-disease-1988-2011-a-population-based-study-of-french-adolescents
#1
Silvia Ghione, Hélène Sarter, Mathurin Fumery, Laura Armengol-Debeir, Guillaume Savoye, Delphine Ley, Claire Spyckerelle, Benjamin Pariente, Laurent Peyrin-Biroulet, Dominique Turck, Corinne Gower-Rousseau
OBJECTIVES: Few data are available to describe the changes in incidence of pediatric-onset inflammatory bowel disease (IBD). The aim of this study was to describe changes in incidence and phenotypic presentation of pediatric-onset IBD in northern France during a 24-year period. METHODS: Pediatric-onset IBD (<17 years) was issued from a population-based IBD study in France between 1988 and 2011. Age groups and digestive location were defined according to the Paris classification...
August 15, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28804920/thiopurines-prevented-surgical-recurrence-in-patients-with-crohn-s-disease-after-intestinal-resection-strategy-based-on-risk-stratification
#2
Jing Guo, Bai-Li Chen, Zhi-Hui Chen, Xia-Peng Luo, Yun Qiu, Sheng-Hong Zhang, Rui Feng, Yao He, Zhi-Rong Zeng, Xin-Ming Song, Shomron Ben-Horin, Ren Mao, Min-Hu Chen
BACKGROUND: Thiopurines (TPs) are effective in reducing risk of clinical and endoscopic recurrence in postoperative patients with Crohn's disease (CD). However, whether TPs could prevent surgical recurrence (SR) remains unknown. AIM: To explore whether TPs could prevent SR and identify risk factors associated with SR in postoperative CD patients. METHODS: This was a retrospective cohort study of 246 postoperative patients with CD. Cox proportional hazard model was used to identify risk factors for SR...
August 14, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28796371/inflammatory-bowel-disease-with-primary-sclerosing-cholangitis-a-danish-population-based-cohort-study-1977-2011
#3
Jakob Ørskov Sørensen, Ole Haagen Nielsen, Mikael Andersson, Mark Andrew Ainsworth, Henriette Ytting, Erika Bélard, Tine Jess
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) may be complicated by primary sclerosing cholangitis (PSC). We aimed to assess the characteristics of Danish PSC-IBD patients and to compare their prognosis with IBD patients without PSC. METHODS: A retrospective nationwide population-based cohort of 257 PSC-IBD patients was assessed through Danish national registries and manual scrutiny of patient files. RESULTS: For all PSC-IBD patients diagnosed after 1976 (n=222) and 8,231 IBD controls (i...
August 10, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28794097/diagnostic-delay-in-canadian-children-with-inflammatory-bowel-disease-is-more-common-in-crohn-s-disease-and-associated-with-decreased-height
#4
Amanda Ricciuto, Jennifer R Fish, Diane E Tomalty, Nicholas Carman, Eileen Crowley, Cynthia Popalis, Aleixo Muise, Thomas D Walters, Anne M Griffiths, Peter C Church
OBJECTIVES: To determine time to diagnosis in a paediatric inflammatory bowel disease (IBD) cohort and the relative contribution of the component intervals, and to identify factors associated with diagnostic delay. DESIGN: Prospective cohort study SETTING: Single-centre study including children with incident IBD at the Hospital for Sick Children diagnosed between December 2013 and December 2015. INTERVENTIONS: Time to diagnosis and its subintervals were determined and patient, disease and institutional factors were tested for associations...
August 9, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28791436/musculoskeletal-health-in-newly-diagnosed-children-with-crohn-s-disease
#5
L M Ward, J Ma, F Rauch, E I Benchimol, J Hay, M B Leonard, M A Matzinger, N Shenouda, B Lentle, H Cosgrove, M Scharke, V N Konji, D R Mack
We evaluated the impact of Crohn's disease on muscle and bone strength, mass, density, and geometry in children with newly diagnosed CD and found profound muscle and bone deficits; nevertheless, the prevalence of vertebral fractures at this time point was low. INTRODUCTION: Crohn's disease (CD) is an inflammatory condition of the gastrointestinal tract that can affect the musculoskeletal system. The objective of this study was to determine the prevalence of vertebral fractures and the impact of CD on muscle and bone mass, strength, density, and geometry in children with newly diagnosed CD...
August 8, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28791279/pneumocystis-jirovecii-pneumonia-in-pediatric-inflammatory-bowel-disease-a-case-report-and-literature-review
#6
Sally J Lawrence, Manish Sadarangani, Kevan Jacobson
Immunosuppressive therapy is a known risk factor for opportunistic infections. We report the first case of severe Pneumocystis jirovecii infection requiring intensive care in a pediatric patient with inflammatory bowel disease (IBD). The literature was reviewed and there were 92 reported cases of Pneumocystis pneumonia (PCP) in patients with IBD. Most sources were case reports and there was likely reporting bias toward patients receiving immunomodulators, anti-tumor necrosis factor (anti-TNF) therapy, and those who died...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28782667/features-of-autoimmune-pancreatitis-associated-with-inflammatory-bowel-diseases
#7
Diane Lorenzo, Frédérique Maire, Carmen Stefanescu, Jean-Marc Gornet, Philippe Seksik, Mélanie Serrero, Barbara Bournet, Philippe Marteau, Aurelien Amiot, David Laharie, Caroline Trang, Benoit Coffin, Guy Bellaiche, Guillaume Cadiot, Catherine Reenaers, Antoine Racine, Stephanie Viennot, Arnaud Pauwels, Guillaume Bouguen, Guillaume Savoye, Anne-Laure Pelletier, Guillaume Pineton de Chambrun, Pierre Lahmek, Stéphane Nahon, Vered Abitbol
BACKGROUND & AIMS: Few people know of autoimmune pancreatitis (AIP), a rare disorder associated with inflammatory bowel diseases (IBD). We aimed to describe phenotype and outcomes of AIP in patients with AIP. METHODS: We performed a retrospective study of cases of AIP in IBD identified from the multi-center Groupe d'Etude Thérapeutique des Affections Inflammatoires du tube Digestif study, performed in Belgium and France from July 2012 through July 2015. Patients were diagnosed with AIP based on histological analysis of pancreatic resection specimens or samples collected by fine-need aspiration during endoscopic ultrasound...
August 3, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28776001/improved-biochemical-parameters-in-patients-who-undergo-early-resection-in-isolated-ileocaecal-crohn-s-disease
#8
Mirzafaraz Saeed, Hari Hullur, Amro Salem, Abbas Ali, Yousif Sahib, Mobeen Ashfaq
INTRODUCTION: The aim of this study is to evaluate the outcome of introduction of early surgery in the course of isolated ileocecal Crohn's disease, where there is no absolute indication of surgery. METHODS: Observational study involving patients with isolated ileocecal Crohn's disease who underwent early surgical resection (within one year of the presentation of the hospital). A complete blood count, ESR, and CRP were done and compared between the preoperative value, 1st postoperative visit (3-4 weeks), and last follow-up visit...
2017: Surgery Research and Practice
https://www.readbyqxmd.com/read/28765701/levels-and-activities-of-von-willebrand-factor-and-metalloproteinase-with-thrombospondin-type-1-motif-number-13-in-inflammatory-bowel-diseases
#9
Dorota Cibor, Danuta Owczarek, Saulius Butenas, Kinga Salapa, Tomasz Mach, Anetta Undas
AIM: To evaluate the levels of von Willebrand factor (VWF) and metalloproteinase with thrombospondin type-1 motif, number 13 (ADAMTS13) in inflammatory bowel disease (IBD) and correlate them with the disease activity. METHODS: Consecutive patients with IBD aged 18 years or older were enrolled in the study. Forty-seven patients with ulcerative colitis (UC), 38 with Crohn's disease (CD), and 50 healthy controls were included. The white blood cell count, haematocrit, platelet count, fibrinogen, partial activated thromboplastin time, C-reactive protein, albumin, VWF antigen level (VWF:Ag), VWF ristocetin cofactor activity (VWF:RCo), VWF collagen-binding activity (VWF:CB), and ADAMTS13 antigen level (ADAMTS13:Ag) and activity (ADAMTS13act) were measured...
July 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28765628/nod2-gene-variants-confer-risk-for-secondary-sclerosing-cholangitis-in-critically-ill-patients
#10
Christoph Jüngst, Vanessa Stadlbauer, Matthias C Reichert, Vincent Zimmer, Susanne N Weber, Lisa Ofner-Ziegenfuß, Torsten Voigtländer, Walter Spindelböck, Peter Fickert, Gabriele I Kirchner, Frank Lammert, Tim O Lankisch, Marcin Krawczyk
Sclerosing cholangitis in critically ill patients (SC-CIP) is a progressive cholestatic disease of unknown aetiology characterized by chronic biliary infections. Hence we hypothesized that common NOD2 (nucleotide-binding oligomerisation domain containing 2) gene variants, known risk factors for Crohn's disease and bacterial translocation in liver cirrhosis, increase the odds of developing SC-CIP. Screening of 4,641 endoscopic retrograde cholangiography procedures identified 17 patients with SC-CIP, who were then genotyped for the three common NOD2 mutations (Cohort 1, discovery cohort)...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28749985/fatigue-in-out-patients-with-inflammatory-bowel-disease-prevalence-and-predictive-factors
#11
Albert Villoria, Víctor García, Angelina Dosal, Laura Moreno, Antònia Montserrat, Ariadna Figuerola, Diana Horta, Xavier Calvet, María José Ramírez-Lázaro
BACKGROUND AND AIM: Fatigue is a common and bothersome symptom in inflammatory bowel disease (IBD) patients. The study was aimed to determine the relationship of biological and psychological factors with IBD-related fatigue. METHODS: Consecutive clinically inactive IBD outpatients receiving immunosuppressants or biological drugs were enrolled between January and December 2013. Patients completed a Fatigue score (FACIT-F), various psychological, quality of life (IBDQ-9), and IBD activity scores...
2017: PloS One
https://www.readbyqxmd.com/read/28748409/evolution-of-clinical-behavior-in-crohn-s-disease-factors-associated-with-complicated-disease-and-surgery
#12
Kátia Simone Cezário de Barros, Cristina Flores, Luciana Harlacher, Carlos Fernando Magalhães Francesconi
BACKGROUND: The phenotypic expression of Crohn's disease may vary over time. Establishment of Crohn's disease phenotypes is important for definition of patient care strategies. AIMS: The aim of the study was to evaluate the long-term evolution of patients based on disease phenotypes and the main factors associated with this evolution. METHODS: Data from 179 patients were collected from a unicentric prospective database. Montreal classification was employed...
July 26, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28737994/impact-of-a-patient-support-program-on-patient-adherence-to-adalimumab-and-direct-medical-costs-in-crohn-s-disease-ulcerative-colitis-rheumatoid-arthritis-psoriasis-psoriatic-arthritis-and-ankylosing-spondylitis
#13
David T Rubin, Manish Mittal, Matthew Davis, Scott Johnson, Jingdong Chao, Martha Skup
BACKGROUND: AbbVie provides a free-to-patient patient support program (PSP) to assist adalimumab-treated patients with medication costs, nurse support, injection training, pen disposal, and medication reminders. The impact of these services on patient adherence to adalimumab and direct medical costs associated with autoimmune disease has not been assessed. OBJECTIVE: To quantify the relationship between participation in a PSP and outcomes (adalimumab adherence, persistence, and direct medical costs) in patients initiating adalimumab treatment...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28735301/effect-of-faecal-calprotectin-assay-variability-on-the-management-of-inflammatory-bowel-disease-and-potential-role-of-faecal-s100a12
#14
Simon John Whitehead, Clare Ford, Rousseau Mariano Gama, Ala Ali, Brian McKaig, Jenna Louise Waldron, Helen Steed, Matthew James Brookes
AIMS: To prospectively evaluate whether between-assay variability of different faecal calprotectin (f-Cp) assays influences diagnostic accuracy for inflammatory bowel disease (IBD) in a cohort of patients with confirmed IBD and irritable bowel syndrome (IBS). To also evaluate the diagnostic accuracy of faecal S100A12 (f-S100A12) against f-Cp in the same patient cohort and assess whether f-S100A12 offers additional diagnostic value. METHODS: F-Cp using four commercially available f-Cp assays, f-S100A12 and blood biomarkers were measured in patients, recruited from the local IBD clinic, who had established IBS or active ulcerative colitis (UC) and Crohn's disease (CD)...
July 22, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28731213/immunomodulatory-properties-of-olea-europaea-leaf-extract-in-intestinal-inflammation
#15
Teresa Vezza, Francesca Algieri, Alba Rodríguez-Nogales, José Garrido-Mesa, M Pilar Utrilla, Nassima Talhaoui, Ana María Gómez-Caravaca, Antonio Segura-Carretero, M Elena Rodríguez-Cabezas, Giovanni Monteleone, Julio Gálvez
SCOPE: Extracts from olive (Olea europaea) leaves are used in Mediterranean traditional medicine as anti-inflammatory. They contain antioxidant phenolic compounds, like oleuropeoside, which could be interesting for the treatment of inflammatory conditions associated with oxidative stress in humans, including inflammatory bowel disease. METHODS AND RESULTS: The anti-inflammatory effects of olive leaf extract (0.5-25 mg/kg) were studied in two mice models of colitis (DSS and DNBS)...
July 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28727653/rising-incidence-of-paediatric-inflammatory-bowel-disease-in-canterbury-new-zealand-1996-2015
#16
Robert N Lopez, Laura Appleton, Richard B Gearry, Andrew S Day
BACKGROUND: The incidence of paediatric inflammatory bowel disease (IBD) around the world is increasing. Canterbury, New Zealand, has one of the highest Crohn's disease (CD) incidence rates published. This study aimed to document the incidence of paediatric IBD in Canterbury between 1996 and 2015. METHODS: All patients diagnosed with IBD in Canterbury, while under 16 years of age, between 1 January 1996 and 31 December 2015 were identified. Demographic and disease phenotypic details were collected and entered into a secure database...
July 19, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28724037/impact-of-biological-therapy-on-body-composition-of-patients-with-chron-s-disease
#17
Julianne Campos Dos Santos, Carla Malaguti, Fernando de Azevedo Lucca, Andrea Lemos Cabalzar, Tarsila Campanha da Rocha Ribeiro, Pedro Duarte Gaburri, Liliana Andrade Chebli, Julio Maria Fonseca Chebli
Introduction: Protein-energy malnutrition in Crohn's disease (CD) has been reported in 20 to 92% of patients, and is associated with increased morbidity and mortality and higher costs for the health system. Anti-TNF drugs are a landmark in the clinical management, promoting prolonged remission in patients with CD. It is believed that the remission of this disease leads to nutritional recovery. The effect of biological therapy on body composition and nutritional status is unclear. Method: Prospective study of body assessment by bioelectrical impedance method in patients with moderate to severe CD undergoing treatment with infliximab...
May 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28719595/risk-of-postoperative-complications-among-inflammatory-bowel-disease-patients-treated-preoperatively-with-vedolizumab
#18
Akihiro Yamada, Yuga Komaki, Nayan Patel, Fukiko Komaki, Arthur S Aelvoet, Anthony L Tran, Joel Pekow, Sushila Dalal, Russell D Cohen, Lisa Cannon, Konstantin Umanskiy, Radhika Smith, Roger Hurst, Neil Hyman, David T Rubin, Atsushi Sakuraba
OBJECTIVES: Vedolizumab is increasingly used to treat patients with ulcerative colitis (UC) and Crohn's disease (CD), however, its safety during the perioperative period remains unclear. We compared the 30-day postoperative complications among patients treated preoperatively with vedolizumab, anti-tumor necrosis factor (TNF)-α agents or non-biological therapy. METHODS: The retrospective study cohort was comprised of patients receiving vedolizumab, anti-TNF-α agents or non-biological therapy within 4 weeks of surgery...
July 18, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28719543/the-association-between-maternal-chronic-inflammatory-bowel-disease-and-long-term-health-outcomes-in-children-a-nationwide-cohort-study
#19
Line R Jølving, Jan Nielsen, Signe S Beck-Nielsen, Rasmus G Nielsen, Sonia Friedman, Ulrik S Kesmodel, Bente M Nørgård
BACKGROUND: Very little is known about the long-term impact of maternal inflammatory bowel disease (IBD) on the offspring's future health. We aimed to examine whether children born to mothers with IBD had an increased risk of long-term morbidities. METHODS: In this nationwide register-based cohort study, including all children born alive in Denmark between 1989 and 2013, we investigated the association between maternal IBD and 15 selected disease categories of physical and mental conditions in the offspring...
August 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28719106/altered-pulmonary-gas-transfer-capacity-and-capillary-blood-volume-in-pediatric-crohn-s-disease
#20
Marie Verstraete, Marie-Luce Choukroun, Valerie Siao-Him Fa, Michael Fayon, Laurent Rebouissoux, Raphael Enaud, Thierry Lamireau
OBJECTIVES: To describe diffusing capacity for carbon monoxide (DLCO) and its components, that is, membrane diffusing capacity (DmCO) and pulmonary capillary blood volume (Vc) in children with Crohn's disease (CD), and to investigate the correlation between these parameters and disease activity. WORKING HYPOTHESIS: The most common lung function abnormalities are a reduced pulmonary DLCO and small airways disorders which are in many instances, clinically silent. No valid explanations have been proposed regarding the modifications in gas transfer capacity in active CD...
August 2017: Pediatric Pulmonology
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