keyword
MENU ▼
Read by QxMD icon Read
search

Crohn's:8

keyword
https://www.readbyqxmd.com/read/27906801/the-prevalence-and-impact-of-functional-abdominal-pain-disorders-in-children-with-inflammatory-bowel-diseases-ibd-fapd
#1
Kevin L Watson, Sandra C Kim, Brendan M Boyle, Miguel Saps
OBJECTIVES: We sought to describe the prevalence of the overlap of functional abdominal pain disorders (FAPDs) in children with inflammatory bowel diseases (IBD), a condition we have designated as IBD-FAPD. We also aimed to describe the psychological profile of this group, assess predictors of disease and the impact of IBD-FAPD on quality of life. METHODS: This cross-sectional prospective study included patients aged 8-18 years with a diagnosis of IBD. Disease activity was assessed by physician's global assessment, laboratory studies, and aPCDAI or PUCAI scoring...
November 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27904960/active-and-passive-involvement-of-claudins-in-the-pathophysiology-of-intestinal-inflammatory-diseases
#2
REVIEW
Christian Barmeyer, Michael Fromm, Jörg-Dieter Schulzke
Intestinal inflammatory diseases, four of which are discussed here, are associated with alterations of claudins. In ulcerative colitis, diarrhea and antigen entry into the mucosa occurs. Claudin-2 is upregulated but data on other claudins are still limited or vary (e.g., claudin-1 and -4). Apart from that, tight junction changes contribute to diarrhea via a leak flux mechanism, while protection against antigen entry disappears behind epithelial gross lesions (erosions) and apoptotic foci. Crohn's disease is additionally characterized by a claudin-5 and claudin-8 reduction which plays an active role in antigen uptake already before gross lesions appear...
November 30, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27895873/value-of-computerized-tomography-enterography-in-predicting-crohn-s-disease-activity-correlation-with-crohn-s-disease-activity-index-and-c-reactive-protein
#3
Eun Kyung Park, Na Yeon Han, Beom Jin Park, Deuk Jae Sung, Sung Beom Cho, Yoon Tae Jeen, Bora Keum, Min Ju Kim
BACKGROUND: The accurate evaluation of Crohn's disease activity is important for the treatment of the disease and for monitoring the response. Computerized tomography (CT) enterography is a useful imaging modality that reflects enteric inflammation, as well as extramural complications. OBJECTIVES: The aim of this study was to evaluate the correlation between CT enterographic (CTE) findings of active Crohn's disease and the Crohn's disease activity index (CDAI) and C-reactive protein (CRP)...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27895429/potential-model-for-differential-diagnosis-between-crohn-s-disease-and-primary-intestinal-lymphoma
#4
Tian-Yu Zhang, Yun Lin, Rong Fan, Shu-Rong Hu, Meng-Meng Cheng, Mao-Chen Zhang, Li-Wen Hong, Xiao-Lin Zhou, Zheng-Ting Wang, Jie Zhong
AIM: To evaluate the usefulness of different parameters to differentiate Crohn's disease (CD) from primary intestinal lymphoma (PIL). METHODS: The medical records of 85 patients with CD and 56 patients with PIL were reviewed retrospectively. Demographic, clinical, laboratory, endoscopic, and computed tomographic enterography (CTE) parameters were collected. The univariate value of each parameter was analyzed. A differentiation model was established by pooling all the valuable parameters...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27892896/c-reactive-protein-as-a-diagnostic-and-prognostic-factor-in-inflammatory-bowel-diseases
#5
Dorota Mańkowska-Wierzbicka, Jacek Karczewski, Barbara Poniedziałek, Małgorzata Grzymisławska, Rafał Staszewski, Aleksandra Królczyk, Agnieszka Dobrowolska, Marian Grzymisławski
AIM: The study aimed to evaluate high-sensitivity CRP (hsCRP) as a diagnostic and predictive marker in patients with inflammatory bowel disease (IBD). MATERIAL/METHODS: Medical history of 106 patients with IBD revealed hsCRP concentrations at diagnosis and during the follow-up period. RESULTS: The study showed that the majority of investigated patients had elevated hsCRP concentrations at diagnosis, although the mean concentration was much higher in the group of patients with Crohn's disease (CD) than the group with ulcerative colitis (UC) (P<0...
November 7, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27890854/association-between-low-trough-levels-of-vedolizumab-during-induction-therapy-for-inflammatory-bowel-diseaseswith-need-for-additional-doses-within-6-months
#6
Nicolas Williet, Gilles Boschetti, Marion Fovet, Thomas Di Bernado, Pierre Claudez, Emilie Del Tedesco, Camille Jarlot, Leslie Rinaldi, Anne Berger, Jean-Marc Phelip, Bernard Flourie, Stéphane Nancey, Stéphane Paul, Xavier Roblin
BACKGROUND & AIMS: We investigated whether serum trough levels of vedolizumab, a humanized monoclonal antibody against integrin alpha 4 beta 7, during the induction phase of treatment can determine whether patients will need additional doses (optimization of therapy) within the first 6 months. METHODS: We conducted an observational study of 47 consecutive patients with Crohn's disease (CD; n=31) or ulcerative colitis (UC; n=16) who had not responded to 2 previous treatment regimens with antagonists of tumor necrosis factor and were starting therapy with vedolizumab at 2 hospitals in France, from June 2014 through April 2016...
November 24, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27890853/chromoendoscopy-for-surveillance-in-ulcerative-colitis-and-crohn-s-disease-a-systematic-review-of-randomized-trials
#7
REVIEW
Andrea Iannone, Marinella Ruospo, Germaine Wong, Mariabeatrice Principi, Michele Barone, Giovanni Fm Strippoli, Alfredo Di Leo
BACKGROUND & AIMS: Key international guideline agencies recommend dysplasia surveillance in inflammatory bowel diseases with chromoendoscopy. We performed a systematic review of randomized trials comparing chromoendoscopy versus other endoscopic techniques for dysplasia surveillance in inflammatory bowel diseases. METHODS: We searched MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials for relevant studies published through September 2016. We estimated risk ratios (RR) for dichotomous outcomes (all-cause/colorectal cancer-related mortality, time to interval cancer, patients with dysplasia, total/subtypes of dysplastic lesions, dysplasia detected by targeted biopsies, adverse events), mean differences (MD) for continuous outcomes (procedural time, costs, total/targeted biopsies) and their 95% confidence intervals (CI) using a random-effects model...
November 24, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27890312/variables-associated-with-loss-of-ileoanal-pouches-constructed-in-childhood
#8
Khaled Abdelaal, Bruce Jaffray
AIMS: To quantify the incidence of loss of an ileoanal pouch in children and to identify variables associated this event. METHODS: Logistic regression of possible explanatory variables: age, sex, indication for procto-colectomy, pre-operative continence status, use of immunosuppressive drugs, open or laparoscopic surgery, number of stages, anastomotic leak, operative complication excluding anastomotic leak, performance of revisional surgery, albumin concentration and platelet count at time of surgery, rank order in series...
November 13, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27885481/post-operative-recurrence-of-crohn-s-disease-after-definitive-stoma-an-underestimated-risk
#9
Dine Koriche, Corinne Gower-Rousseau, Charbel Chater, Alain Duhamel, Julia Salleron, Noémie Tavernier, Jean-Frédéric Colombel, Benjamin Pariente, Antoine Cortot, Philippe Zerbib
INTRODUCTION: Crohn's disease (CD) is a progressive inflammatory disease affecting the entire gastrointestinal tract. The need for a definitive stoma (DS) is considered as the ultimate phase of damage. It is often believed that the risk of further disease progression is small when a DS has been performed. AIMS: The goals of the study were to establish the rate of CD recurrence above the DS and to identify predictive factors of CD recurrence at the time of DS. METHODS: We retrospectively reviewed all medical records of consecutive CD patients having undergone DS between 1973 and 2010...
November 24, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27883215/effects-of-concomitant-immunomodulators-on-the-pharmacokinetics-efficacy-and-safety-of-adalimumab-in-patients-with-crohn-s-disease-or-ulcerative-colitis-who-had-failed-conventional-therapy
#10
J-F Colombel, B Jharap, W J Sandborn, B Feagan, L Peyrin-Biroulet, S F Eichner, A M Robinson, N M Mostafa, Q Zhou, R B Thakkar
BACKGROUND: Adalimumab is approved for use in patients with moderate to severe Crohn's disease (CD) or ulcerative colitis (UC) who have not achieved disease control with conventional therapies including corticosteroids and/or immunomodulators (IMM). AIM: To analyse six studies that examined efficacy, pharmacokinetics and safety of combination IMM/adalimumab therapy, compared with adalimumab monotherapy in patients with inadequate disease control on conventional therapy...
January 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27882164/inflammatory-bowel-disease-in-chinese-children-a-retrospective-analysis-of-49-cases
#11
Ying Zhou, Ying Huang
To present study reports the clinical characteristics, diagnosis and management of pediatric patients with inflammatory bowel disease (IBD) in China. Clinical records of 49 pediatric patients with IBD at Fudan University Children's Hospital (Shanghai, China) between July 2001 and May 2012 were reviewed. Of 49 patients (30 males and 19 females), 8 patients had ulcerative colitis (UC) and 41 patients had Crohn's disease (CD). The mean age was 10.4 years in patients with UC and 10.1 years in patients with CD. The percentages of patients with UC with abdominal pain, diarrhea or rectal bleeding were 62...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27878619/an-open-prospective-study-evaluating-efficacy-and-safety-of-a-new-medical-device-for-rectal-application-of-activated-carbon-in-the-treatment-of-chronic-uncomplicated-perianal-fistulas
#12
Antoni Zawadzki, Louis Banka Johnson, Måns Bohe, Claes Johansson, Mats Ekelund, Ole Haagen Nielsen
PURPOSE: It has been proposed that biological/chemical substances in the intestine might play a role in the occurrence and deterioration of perianal fistulas. Elimination of such unidentified factors from the lower gastrointestinal tract might offer a new strategy for the management of anal fistulas. The aim of this study was to evaluate the clinical effects on non-Crohn's disease perianal fistula healing, and the safety and tolerability of a new medical device that applies high-purity, high-activity granular activated carbon locally into the rectum twice daily of patients with perianal fistulas without any concomitant medication...
November 23, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27875505/radiologic-predictors-of-surgery-in-newly-diagnosed-pediatric-crohn-disease-patients
#13
Damien Parker, Boaz Karmazyn, Steven J Steiner
OBJECTIVES: The aim of the present study was to assess whether small bowel imaging conducted at the time of diagnosis could be used as a predictor of small bowel surgical intervention in a population of pediatric patients with Crohn disease (CD). METHODS: A retrospective analysis of small bowel imaging within 30 days of diagnosis of pediatric CD was conducted. Patients were divided into 2 groups based on small bowel imaging: those with no or minor abnormalities (71%) and those with more extensive or obstructive abnormalities (29%)...
December 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27864666/evaluation-of-serum-trace-element-levels-and-superoxide-dismutase-activity-in-patients-with-inflammatory-bowel-disease-translating-basic-research-into-clinical-application
#14
Erfan Mohammadi, Durdi Qujeq, Hassan Taheri, Karimollah Hajian-Tilaki
The relationship of minerals and trace elements with inflammatory bowel disease (IBD) is complex. Alterations in their metabolism can be induced by the diseases and their complications. To study the role of trace elements in IBD patients' serum zinc and copper and their related enzymes, including superoxide dismutase (SOD), activity were measured in patients with IBD patients as well as in healthy subjects. In addition, the correlation between serum trace element levels, albumin, total protein, urea level, copper/zinc ratio, and disease activity (DA) was determined in these subjects...
November 18, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27864028/anti-tnf-therapy-is-able-to-stabilize-bowel-damage-progression-in-patients-with-crohn-s-disease-a-study-performed-using-the-l%C3%A3-mann-index
#15
Giorgia Bodini, Edoardo G Giannini, Costanza De Maria, Pietro Dulbecco, Manuele Furnari, Elisa Marabotto, Vincenzo Savarino, Edoardo Savarino
AIMS: The Lémann Index (LI) was developed to assess the cumulative structural damage of the intestinal tract in patients with Crohn's Disease (CD) independently of clinical and biochemical activity. Recently, the goal of CD focused on obtaining mucosal healing and deep remission rather than simple symptom control. These new therapeutic aims emphasize the need to prevent progression of bowel damage. In this study we aimed to evaluate the influence of different treatments on structural damage progression, assessed by means of LI in a series of CD patients consistently treated with various drugs...
November 2, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27856364/incidence-and-prevalence-of-crohn-s-disease-and-ulcerative-colitis-in-olmsted-county-minnesota-from-1970-through-2010
#16
Raina Shivashankar, William J Tremaine, W Scott Harmsen, Edward V Loftus
BACKGROUND & AIMS: The incidence and prevalence of inflammatory bowel diseases (IBD) continue to increase worldwide. We sought to update incidence rates of Crohn's disease (CD) and ulcerative colitis (UC) in a well-defined United States (US) population, calculating values for Olmsted County, Minnesota through 2010. We also calculated prevalence values. METHODS: The resources of the Rochester Epidemiology Project were used to identify county residents who were diagnosed with IBD (CD or UC), based on previously set criteria...
November 14, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27855604/novel-microrna-signature-to-differentiate-ulcerative-colitis-from-crohn-disease-a-genome-wide-study-using-next-generation-sequencing
#17
Jingmei Lin, Xinjun Zhang, Zijin Zhao, Noah Welker, Yong Li, Yunlong Liu, Mary Bronner
BACKGROUND: The diagnosis of ulcerative colitis (UC) or Crohn disease (CD) can be challenging given the overlapping features. Knowledge of microRNAs in IBD has expanded recently and supports that microRNAs play an important role. This study aimed to identify novel microRNA biomarkers through comprehensive genome-wide sequencing to distinguish UC from CD. DESIGN: Illumina next generation sequencing was performed on nondysplastic fresh-frozen colonic mucosa of the distal-most colectomy from 19 patients (10 UC and 9 CD) and 18 patients with diverticular disease serving as controls...
November 17, 2016: MicroRNA
https://www.readbyqxmd.com/read/27832710/radiation-exposure-in-patients-with-inflammatory-bowel-disease-and-irritable-bowel-syndrome-in-the-years-2001-2011
#18
Hanna Englund, Katarina Lidén K, Torbjörn Lind, Torbjörn Sundström, Pontus Karling
OBJECTIVES: To compare cumulative ionizing radiation in patients with inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) for the years 2001-2011. To study how radiation exposure change over time in patients with newly diagnosed IBD and factors associated with radiation exposure. MATERIAL AND METHODS: All radiological investigations performed between 1 January 2001 and 31 December 2011 were retrospectively recorded in patients with Crohn's disease (CD) (n = 103), ulcerative colitis (UC) (n = 304) and IBS (n = 149)...
November 10, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27832426/long-term-outcomes-in-indeterminate-colitis-patients-undergoing-ileal-pouch-anal-anastomosis-function-quality-of-life-and-complications
#19
Katharine L Jackson, Luca Stocchi, Leonardo Duraes, Ahmet Rencuzogullari, Ana E Bennett, Feza H Remzi
INTRODUCTION: It is uncertain whether the outcomes of patients with indeterminate colitis (IC) undergoing ileal pouch-anal anastomosis (IPAA) deteriorate over time. The aim of this study was to determine the long-term pouch function, quality of life, complications, and incidence of Crohn's disease after IPAA for patients with IC compared to ulcerative colitis (UC). METHODS: A case matched analysis was performed on patients undergoing IPAA for pathologically confirmed IC or UC, between 1985 and 2014...
November 10, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27816758/comparison-of-endoscopic-dilation-versus-surgery-for-anastomotic-stricture-in-patients-with-crohn-s-disease-following-ileocolonic-resection
#20
Lei Lian, Luca Stocchi, Feza H Remzi, Bo Shen
BACKGROUND & AIMS: It is not clear whether endoscopic balloon dilation (EBD) or surgery is a more effective treatment for ileocolonic anastomosis (ICA) stricture in patients with Crohn's disease. We aimed to compare long-term outcomes of patients who underwent EBD versus surgery for ICA stricture. METHODS: We performed a retrospective study of adult patients with ICA stricture treated with EBD (n = 176) or surgery (n = 131), from December 1998 through May 2013, at the Cleveland Clinic Foundation...
November 2, 2016: Clinical Gastroenterology and Hepatology
keyword
keyword
53050
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"