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https://www.readbyqxmd.com/read/28927047/msk1-downregulation-is-associated-with-neuronal-and-astrocytic-apoptosis-following-subarachnoid-hemorrhage-in-rats
#1
Bo Ning, Geng Guo, Hong Liu, Lei Ning, Bao-Liang Sun, Zhen Li, Shuo Wang, Zheng-Wen Lv, Cun-Dong Fan
MSK (mitogen- and stress-activated protein kinase) proteins are a family of mitogen-activated protein kinases. MSKs represent a novel type of pro-survival genes, potentially enhancing the phosphorylation of Bcl2-associated agonist of cell death. However, MSK's function and expression are poorly understood in the central nervous system. In the present study, a subarachnoid hemorrhage (SAH) model was established in SD rats and the expression of MSK1 in the brain subsequent to experimental SAH was investigated...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28924463/development-of-a-valid-and-reliable-questionnaire-to-identify-professional-opinion-regarding-organ-transplantation-system
#2
B Sah, A Ayer, B N Yadav, S Jha, S K Yadav
BACKGROUND: Currently, the Nepalese law permits organ donation by an individual who falls into the category of a "close relative" of the recipient. There is a need for expansion of the live organ donor pool beside close relatives. Different systems of organ transplantation are followed by several countries and the professional opinions that underpin these systems need to be studied. OBJECTIVE: To generate a questionnaire related to different organ transplant systems and validate it so that it can be used to collect mass professional opinions...
2017: International Journal of Organ Transplantation Medicine
https://www.readbyqxmd.com/read/28920549/rupture-of-a-non-traumatic-anterior-communicating-artery-aneurysm-does-location-of-aneurysm-associate-with-functional-independence-following-post-acute-in-patient-neurorehabilitation
#3
Henriette Holm Stabel, Asger Roer Pedersen, Søren Paaske Johnsen, Jørgen Feldbæk Nielsen
OBJECTIVE: Patients with non-traumatic rupture of an aneurysm located at the anterior communicating artery (ACoA) often experience cognitive disabilities. It is unknown whether location of aneurysm also affects the possibility for improvement in functional independence compared to patients with an aneurysmal subarachnoid hemorrhage (a-SAH) located elsewhere. The aim was to explore the association between location of aneurysm (ACoA versus other) and level of functional independence, measured by Functional Independence Measure (FIM), at discharge from rehabilitation...
September 18, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28919611/incidental-thyroid-carcinoma-in-patients-treated-surgically-for-presumably-benign-thyroid-disease
#4
M M Rahman, U S Abdullah, A I Joarder, C Das, B C Debnath, R Sah
Incidental Thyroid Carcinoma (ITC) is quite high as been reported in the world's Journal. This study reviews the frequency of the ITC in patients treated surgically for otherwise benign Thyroid disease in one of the Endocrine surgery unit of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. This study was developed by the investigating the outcome of one hundred and twenty seven patient who underwent partial or total thyroidectomy for benign thyroid pathology in a single Endocrine Surgery Unit of BSMMU from January 2011 to July 2015...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28914252/unilateral-fourth-fifth-sixth-and-seventh-molar-in-a-nonsyndromic-patient-a-rare-and-unusual-case-report
#5
Pallav Singhal, Vikash Kumar Sah, Alok Kumar, Anu Garg
Multiple supernumerary teeth are rare developmental anomalies which are often associated with syndromes. Only few examples of nonsyndromic supernumerary teeth have been reported with fourth, fifth, sixth, and seventh molar rarest of all. The cause, frequency, complications, and surgical operation of supernumerary teeth are always interesting subjects for study and research. Literature reports increased occurrence of the supernumeraries in the maxilla, but here, a unique and unusual case report of 12-year-old female patient with unilateral multiple impacted supernumerary teeth in the mandible in otherwise healthy individual has been presented...
October 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28913624/emergency-neurological-life-support-subarachnoid-hemorrhage
#6
Brian L Edlow, Owen Samuels
Subarachnoid hemorrhage (SAH) is a neurological emergency because it may lead to sudden neurological decline and death and, depending on the cause, has treatment options that can return a patient to normal. Because there are interventions that can be life-saving in the first few hours after onset, SAH was chosen as an Emergency Neurological Life Support (ENLS) protocol.
September 14, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28912978/anoxic-brain-injury-presenting-as-pseudosubarachnoid-hemorrhage-in-the-medical-intensive-care-unit
#7
O'Dene Lewis, Samina Afreen, Supo Folaranmi, Marie Fidelia-Lambert, Vishal Poddar, Alicia Thomas
Anoxic encephalopathy is frequently encountered in the medical intensive care unit (ICU). Cerebral edema as a result of anoxic brain injury can result in increased attenuation in the basal cisterns and subarachnoid spaces on computerized tomography (CT) scans of the head. These findings can mimic those seen in acute subarachnoid hemorrhage (SAH) and are referred to as pseudosubarachnoid hemorrhage (pseudo-SAH). Pseudo-SAH is a diagnosis critical care physicians should be aware of as they treat and evaluate their patients with presumed SAH, which is a medical emergency...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/28912935/baicalin-attenuates-subarachnoid-hemorrhagic-brain-injury-by-modulating-blood-brain-barrier-disruption-inflammation-and-oxidative-damage-in-mice
#8
Xianqing Shi, Yongjian Fu, SongSong Zhang, Hao Ding, Jin Chen
In subarachnoid hemorrhagic brain injury, the early crucial events are edema formation due to inflammatory responses and blood-brain barrier disruption. Baicalin, a flavone glycoside, has antineuroinflammatory and antioxidant properties. We examined the effect of baicalin in subarachnoid hemorrhagic brain injury. Subarachnoid hemorrhage was induced through filament perforation and either baicalin or vehicle was administered 30 min prior to surgery. Brain tissues were collected 24 hours after surgery after evaluation of neurological scores...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28912747/decreasing-risk-of-fatal-subarachnoid-hemorrhage-and-other-epidemiological-trends-in-the-era-of-coiling-implementation-in-australia
#9
John Mark Worthington, Chris Goumas, Bin Jalaludin, Melina Gattellari
BACKGROUND AND PURPOSE: Subarachnoid hemorrhage (SAH) is associated with a high risk of mortality and disability in survivors. We examined the epidemiology and burden of SAH in our population during a time services were re-organized to facilitate access to evidence-based endovascular coiling and neurosurgical care. METHODS: SAH hospitalizations from 2001 to 2009, in New South Wales, Australia, were linked to death registrations to June 30, 2010. We assessed the variability of admission rates, fatal SAH rates and case fatality over time and according to patient demographic characteristics...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28904716/-supracricoid-partial-laryngectomy-scpl-with-either-cricohyoidoepiglottopexy-chep-our-experience-with-16-cases
#10
Bouchaib Hemmaoui, Mohamed Sahli, Noureddine Errami, Ahmed Rouihi, Mohamed Habib Bahalou, Ilias Benchaifai, Amine Ennouali, Sara Britel, Ismail Nakkabi, Ali Jahidi, Mohamed Zalagh, Saloua Ouaraini, Fouad Benariba
Partial laryngectomy with either cricohyoidoepiglottopexy (CHEP) are mainly used to treat glottic cancers becuse they ensure a satisfactory preservation of physiological functions and satisfactory local carcinologic control. Our study aimed to analyze the functional and carcinologic results of this surgical technique. We conducted a retrospective study of patients undergoing partial laryngectomy with either cricohyoidoepiglottopexy in our Hospital between 2011 and 2014. We analyzed the epidemiological data, the surgical peculiarities, the functional outcomes and the carcinologic control of the disease...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28903766/fluoxetine-enhanced-autophagy-ameliorates-early-brain-injury-via-inhibition-of-nlrp3-inflammasome-activation-following-subrachnoid-hemorrhage-in-rats
#11
Jian-Ru Li, Hang-Zhe Xu, Sheng Nie, Yu-Cong Peng, Lin-Feng Fan, Zhi-Jiang Wang, Cheng Wu, Feng Yan, Jing-Yin Chen, Chi Gu, Chun Wang, Jing-Sen Chen, Lin Wang, Gao Chen
BACKGROUND: The NLRP3 inflammasome is a multiprotein complex that regulates the innate immune inflammatory response by activating caspase-1 and subsequent IL-1β and IL-18. Fluoxetine has been shown to have the anti-inflammatory properties in many disease models. However, the effects and mechanisms of these effects of fluoxetine in early brain injury after subarachnoid hemorrhage (SAH) have not been defined. METHODS: The SAH model was induced by an endovascular perforation in adult male Sprague-Dawley (SD) rats weighing 300-320 g...
September 13, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28899731/combined-physical-cognitive-training-enhances-postural-performances-during-daily-life-tasks-in-older-adults
#12
Rabeb Laatar, Hiba Kachouri, Rihab Borji, Haithem Rebai, Sonia Sahli
Physical-cognitive interventions seem promising to improve balance and gait performances and prevent falls in the elderly. Although these beneficial effects, it is still not clear whether these physical-cognitive training modalities leads to more general non-specific adaptations that can be transferred to some measures reflecting every day abilities. This randomized controlled trial examined postural (center of pressure oscillations), physical (lower body strength, gait speed, functional mobility, dynamic balance) and cognitive performances (reaction time) and postural performance during daily life tasks (walking while conversing on a phone and maintaining an upright standing posture while buttoning a shirt) in older adults (66...
September 9, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28894433/amino-acids-in-cerebrospinal-fluid-of-patients-with-aneurysmal-subarachnoid-haemorrhage-an-observational-study
#13
Bartosz Sokół, Bartosz Urbaniak, Norbert Wąsik, Szymon Plewa, Agnieszka Klupczyńska, Roman Jankowski, Barbara Więckowska, Robert Juszkat, Zenon Kokot
BACKGROUND: The authors are aware of only one article investigating amino acid concentrations in cerebrospinal fluid (CSF) in patients with ruptured intracranial aneurysms, and this was published 31 years ago. Since then, both management of subarachnoid haemorrhage (SAH) and amino acid assay techniques have seen radical alterations, yet the pathophysiology of SAH remains unclear. OBJECTIVE: To analyse the pattern of concentrations of amino acids and related compounds in patients with different outcomes following aneurysmal SAH...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28893694/altered-expression-of-microrna-15a-and-kruppel-like-factor-4-in-cerebrospinal-fluid-and-plasma-after-aneurysmal-subarachnoid-hemorrhage
#14
Yuichiro Kikkawa, Takeshi Ogura, Hiroyuki Nakajima, Toshiki Ikeda, Ririko Takeda, Hiroaki Neki, Shinya Kohyama, Fumitaka Yamane, Ryota Kurogi, Toshiyuki Amano, Akira Nakamizo, Masahiro Mizoguchi, Hiroki Kurita
BACKGROUND: Cerebral vasospasm (CVS) is a major determinant of prognosis in patients with subarachnoid hemorrhage (SAH). Alteration in the vascular phenotype contributes to development of CVS. However, little is known about the role of microRNAs (miRNAs) in the phenotypic alteration after SAH. We investigated the expression profile of miRNAs and the chronological changes in the expression of microRNA-15a (miR-15a) and Kruppel-like factor 4 (KLF4), a potent regulator of vascular phenotype modulation that modulates the expression of miR-15a, in the plasma and cerebrospinal fluid (CSF) of SAH patients...
September 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28890766/some-biological-aspects-of-bigeye-scad-selar-crumenophthalmus-from-bangaa-faru-maldives
#15
Nik Fadzly, Shaza Adeeb, Amir Shah Ruddin Md Sah
In this paper, we studied some biological aspects of big eye scad (Selar crumenophthalmus) from Maldives. The fish sample was collected from the local fish market at Bangaa Faru, Male, Maldives. The length of the samples were ranged from 7.7 cm to 24.5 cm (mean value = 16.85 ± 2.82 cm) in fork length. Body weight ranged between 8 g to 255.6 g (mean value = 87.76 ± 40.41 g). The exponent values (b slope) of lengthweight relationship of S. crumenophthalmus are 2.9838 for females and 2.7687 for males; indicating negative allometric growth pattern for both sexes...
July 2017: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/28890759/general-perceptions-and-awareness-level-among-local-residents-in-penang-island-toward-bats-conservation-efforts
#16
Nur Juliani Shafie, Shahrul Anuar Mohd Sah, Aini Hasanah Abdul Mutalib, Nik Fadzly
The population of bats has declined from year to year caused by human activities such as logging and hunting activities. Since the human factor is linked to the issues of population decline in many animal species, a community-based conservation strategy that involved local communities is needed. We conducted face-to-face surveys among residents in Penang Island to assess knowledge and awareness level toward bats conservation efforts. We collected demographic values such as age, gender, level of education, length of residency as well as their monthly income, since different group in these variable might have different perception...
July 2017: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/28887618/diagnostic-value-of-3d-time-of-flight-magnetic-resonance-angiography-for-detecting-intracranial-aneurysm-a-meta-analysis
#17
REVIEW
Liu HaiFeng, Xu YongSheng, Xun YangQin, Dou Yu, Wang ShuaiWen, Lu XingRu, Lei JunQiang
PURPOSE: This meta-analysis is to comprehensively evaluate the diagnostic performance of three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA) for detecting intracranial aneurysm (IA). METHODS: PubMed, Embase, Web of Science, and the Cochrane library were systematically searched for retrieving eligible studies. Study inclusion, data extraction, and risk of bias assessment were performed by two researchers independently. Pooled sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were calculated to assess the diagnostic value...
September 8, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28883775/seasonal-and-monthly-variation-in-stroke-and-its-subtypes-10-year-hospital-based-study
#18
Ahmad Bahonar, Alireza Khosravi, Fariborz Khorvash, Mohammadreza Maracy, Mohammad Saadatnia
BACKGROUND AND OBJECTIVES: There is no evidence of long-term studies of seasonal variations in stroke in Iran. Hence, the aim of this study was to determine the seasonal and monthly variation of 28-day mortality in Isfahan, Iran. METHODS: From 2003 to 2013, In a Hospital-based retrospective study, 24186 cases with first-ever stroke were analyzed in Isfahan. Multinomial logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals (CI) for seasonal and monthly 28-day mortality for stroke in general and three subtypes of stroke including intracranial hemorrhage (ICH), ischemic (IS) and subarachnoid hemorrhage (SAH)...
June 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/28883658/running-reorganizes-the-circuitry-of-one-week-old-adult-born-hippocampal-neurons
#19
Nirnath Sah, Benjamin D Peterson, Susan T Lubejko, Carmen Vivar, Henriette van Praag
Adult hippocampal neurogenesis is an important form of structural and functional plasticity in the mature mammalian brain. The existing consensus is that GABA regulates the initial integration of adult-born neurons, similar to neuronal development during embryogenesis. Surprisingly, virus-based anatomical tracing revealed that very young, one-week-old, new granule cells in male C57Bl/6 mice receive input not only from GABAergic interneurons, but also from multiple glutamatergic cell types, including mature dentate granule cells, area CA1-3 pyramidal cells and mossy cells...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28881216/who-provides-inconsistent-reports-of-their-health-status-the-importance-of-age-cognitive-ability-and-socioeconomic-status
#20
Nicole Black, David W Johnston, Michael A Shields, Agne Suziedelyte
Self-assessed health (SAH) measures are widely used in models of health and health inequalities. Such models assume that SAH is a reliable measure of health status. We utilise a unique feature of a national longitudinal survey to examine the consistency of responses to a standard SAH question that is asked twice to the same individual in close temporal proximity in up to three waves (2001, 2009, and 2013). In particular, we analyse whether the consistency of responses varies with personal characteristics. The main analysis sample includes 18,834 individual-year observations...
August 26, 2017: Social Science & Medicine
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