Tiefeng Jin, Lingling Ding, Jinming Chen, Xiaozhou Zou, Tong Xu, Zixue Xuan, Shanshan Wang, Jianqiang Chen, Wei Wang, Chaozhuang Zhu, Yiwen Zhang, Ping Huang, Zongfu Pan, Minghua Ge
Chromosome instability (CIN) is a common contributor driving the formation and progression of anaplastic thyroid cancer (ATC), but its mechanism remains unclear. The BUB1 mitotic checkpoint serine/threonine kinase (BUB1) is responsible for the alignment of mitotic chromosomes, which has not been thoroughly studied in ATC. Our research demonstrated that BUB1 was remarkably upregulated and closely related to worse progression-free survival. Knockdown of BUB1 attenuated cell viability, invasion, migration and induced cell cycle arrests, whereas overexpression of BUB1 promoted the cell cycle progression of papillary thyroid cancer cells...
April 2024: Journal of Cellular and Molecular Medicine