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Collective migration metastasis

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https://www.readbyqxmd.com/read/29764768/hydroxylase-activity-of-asph-promotes-hepatocellular-carcinoma-metastasis-through-epithelial-to-mesenchymal-transition-pathway
#1
Qifei Zou, Ying Hou, Haibo Wang, Kui Wang, Xianglei Xing, Yong Xia, Xuying Wan, Jun Li, Binghua Jiao, Jingfeng Liu, Aimin Huang, Dong Wu, Hongjun Xiang, Timothy M Pawlik, Hongyang Wang, Wan Yee Lau, Yizheng Wang, Feng Shen
Over-expression of aspartyl (asparagynal)-β-hydroxylase (ASPH) contributes to hepatocellular carcinoma (HCC) invasiveness, but the role of ASPH hydroxylase activity in this process remains to be defined. As such, the current study investigated the role of ASPH hydroxylase activity in downstream signalling of HCC tumorgenesis and, specifically, metastasis development. Over-expression of wild-type ASPH, but not a hydroxylase mutant, promoted HCC cell migration in vitro, as well as intrahepatic and distant metastases in vivo...
May 12, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29760678/controversial-role-of-kisspeptins-kiss-1r-signaling-system-in-tumor-development
#2
REVIEW
Federica Fratangelo, Maria Vincenza Carriero, Maria Letizia Motti
KiSS-1 was first described as a metastasis suppressor gene in malignant melanoma. KiSS-1 encodes a 145 amino-acid residue peptide that is further processed, producing the 54 amino acid metastin and shorter peptides collectively named kisspeptins (KPs). KPs bind and activate KiSS-1R (GPR54). Although the KPs system has been extensively studied for its role in endocrinology of reproductive axis in mammals, its role in cancer is still controversial. Experimental evidences show that KP system exerts an anti-metastatic effect by the regulation of cellular migration and invasion in several cancer types...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29758456/gper-hippo-yap-signal-is-involved-in-bisphenol-s-induced-migration-of-triple-negative-breast-cancer-tnbc-cells
#3
Qianqian Deng, Guanmin Jiang, Yingmin Wu, Jiexin Li, Weiting Liang, Likun Chen, Qiao Su, Wuguo Li, Jun Du, Chris K C Wong, Zhuojia Chen, Hongsheng Wang
Nowadays, risk factors of triple-negative breast cancer (TNBC) metastasis are not well identified. Our present study reveals that an industrial chemical, bisphenol S (BPS), can promote the migration, but not the proliferation, of TNBC cells in vitro. BPS activates YAP, a key effector of Hippo pathway, by inhibiting its phosphorylation, which promotes YAP nuclear accumulation and up-regulates its downstream genes such as CTGF and ANKRD1. Inhibition of YAP blocks the BPS-triggered cell migration and up-regulation of fibronectin (FN) and vimentin (Vim)...
May 8, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29747316/-abnormal-expression-of-angiopoietin-2-associated-with-invasion-metastasis-and-prognosis-of-lung-cancer
#4
L W Qiu, J R Chen, X L Yang, M Fang, W J Zheng, Z Z Dong, M Yao, D F Yao
Objective: To investigate the relationship between abnormal angiopoietin-2 (Ang-2) expression and invasion/metastasis of lung cancer. Methods: Totally 122 cases of postoperative primary lung cancer tissues and their paracancerous tissues from Jan. 2009 to Dec. 2010 were collected from Affiliated Hospital of Nantong University and Ang-2 expression was analyzed by immunohistochemistry. At the cellular level, the protein and mRNA levels of Ang-2 in lung epithelial cell line Beas-2B and four lung cancer cell lines (SPCA-1, NCI-1650, A549 and NCI-H1975) were observed...
April 24, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29733962/extracellular-atp-drives-breast-cancer-cell-migration-and-metastasis-via-s100a4-production-by-cancer-cells-and-fibroblasts
#5
Ying Liu, Yue-Hang Geng, Hui Yang, Han Yang, Yan-Ting Zhou, Hong-Quan Zhang, Xin-Xia Tian, Wei-Gang Fang
Our previous work has demonstrated that extracellular ATP is an important pro-invasive factor, and in this study, we tapped into a possible mechanism involved. We discovered that ATP could upregulate both the intracellular expression and secretion of S100A4 in breast cancer cells and fibroblasts. Apart from stimulating breast cancer cell motility via intracellular S100A4, ATP enhanced the ability of breast cancer cells to transform fibroblasts into cancer-associated fibroblast (CAF)-like cells, which in turn secreted S100A4 to further promote cancer cell motility...
May 4, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29731866/microrna-hsa-let-7e-5p-as-a-potential-prognosis-marker-for-rectal-carcinoma-with-liver-metastases
#6
Wenfeng Chen, Guosheng Lin, Yizhou Yao, Jishen Chen, Hanli Shui, Qinghai Yang, Xiaoya Wang, Xiaoyuan Weng, Ling Sun, Fei Chen, Sheng Yang, Yufeng Yang, Yongjian Zhou
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that target mRNAs for translational repression or cleavage. The present study was conducted to identify differentially expressed miRNAs in primary tumor tissues of rectal carcinoma (RC) that may be associated with heterochrony hepatic metastasis (HHM). Samples were collected exclusively from patients with RC but not colon cancer (CC); Next-generation high-throughput sequencing technology and bioinformatics tools were used to profile and analyze small RNAs and their corresponding targets in primary tumor tissues with HHM (n=2) or without metastases (non-metastatic, NM; n=2)...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29725366/application-values-of-mir-194-and-mir-29-in-the-diagnosis-and-prognosis-of-gastric-cancer
#7
Xin Zhao, Yunxia Hou, Zhongzhen Tuo, Fangmeng Wei
The object of this study was to analyze the expression of miR-194 and miR-29 in gastric cancer and their roles in the regulation of malignant phenotype of gastric cancer cells, and to explore the application value of miR-194 and miR-29 in diagnosis and prognosis of gastric cancer. Tumor tissue and adjacent healthy tissue of 165 gastric cancer patients diagnosed by pathologic examinations were collected. Expression of miR-194 and miR-29 in the tissues was detected by RT-PCR. The relationship between miR-194 and miR-29 expression and clinical data was analyzed...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29719608/c-jun-dependent-%C3%AE-3gnt8-promotes-tumorigenesis-and-metastasis-of-hepatocellular-carcinoma-by-inducing-cd147-glycosylation-and-altering-n-glycan-patterns
#8
Chunliang Liu, Hao Qiu, Dandan Lin, Zerong Wang, Ning Shi, Zengqi Tan, Jun Liu, Zhi Jiang, Shiliang Wu
β3GnT8, a key polylactosamine synthase, plays a vital role in progression of various types of human cancer. The role of β3GnT8 in hepatocellular carcinoma (HCC) and the underlying mechanisms, however, remain largely unknown. In this study, we found that β3GnT8 and polylactosamine were highly expressed in HCC tissues compared with those in adjacent paracancer tissues. Overexpression of β3GnT8 promoted while knockdown of β3GnT8 inhibited HCC cell invasion and migration in vitro . Importantly, enhanced tumorigenesis was observed in nude mice inoculated with β3GnT8-overexpressing HCC cells, suggesting that β3GnT8 is important for HCC development in vitro and in vivo ...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29717134/g3bp1-promotes-tumor-progression-and-metastasis-through-il-6-g3bp1-stat3-signaling-axis-in-renal-cell-carcinomas
#9
Yong Wang, Donghe Fu, Yajing Chen, Jing Su, Yiting Wang, Xin Li, Wei Zhai, Yuanjie Niu, Dan Yue, Hua Geng
The chronic inflammatory microenvironment within or surrounding the primary renal cell carcinoma (RCC) site promotes oncogenic transformation as well as contributes to the development of metastasis. G3BP stress granule assembly factor 1 (G3BP1) was found to be involved in the regulation of multiple cellular functions. However, its functions in RCC have not been previously explored. Here, we first showed that the expression of G3BP1 is elevated in human RCC and correlates with RCC progression. In cultured RCC cells, knockdown of G3BP1 results in inhibition of tumor cell proliferation, migration, and invasion, consistently with the alteration of epithelial-mesenchymal transition (EMT) and cell proliferative markers, including Cadherins, Vimentin, Snail, Slug, c-Myc, and cyclin D1...
May 2, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29717112/gastrin-stimulates-pancreatic-cancer-cell-directional-migration-by-activating-the-g%C3%AE-12-13-rhoa-rock-signaling-pathway
#10
Ganggang Mu, Qianshan Ding, Hongyan Li, Li Zhang, Lingli Zhang, Ke He, Lu Wu, Yunchao Deng, Dongmei Yang, Lianlian Wu, Ming Xu, Jie Zhou, Honggang Yu
The mechanism by which gastrin promotes pancreatic cancer cell metastasis is unclear. The process of directing polarized cancer cells toward the extracellular matrix is principally required for invasion and distant metastasis; however, whether gastrin can induce this process and its underlying mechanism remain to be elucidated. In this study, we found that gastrin-induced phosphorylation of paxillin at tyrosine 31/118 and RhoA activation as well as promoted the metastasis of PANC-1 cancer cells. Depletion of Gα12 and Gα13 inhibited the phosphorylation of paxillin and downstream activation of GTP-RhoA, blocked the formation and aggregation of focal adhesions and facilitated polarization of actin filaments induced by gastrin...
May 1, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29710538/mir-338-5p-promotes-the-growth-and-metastasis-of-malignant-melanoma-cells-via-targeting-cd82
#11
Jianwen Long, Jing Luo, Xuwen Yin
BACKGROUND: Melanoma has been a severe threat to human health, microRNAs play vital roles in the oncogenesis and progression of cancers. In this report, the roles and mechanism of miR-338-5p were investigated in the development of melanoma. MATERIALS AND METHODS: A total of 46 melanoma samples and 25 normal nevi samples were collected. Real time reverse transcriptase polymerase chain reaction and Western blot were used to detect the expression of mRNA and protein...
April 6, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29706618/ecd-promotes-gastric-cancer-metastasis-by-blocking-e3-ligase-zfp91-mediated-hnrnp-f-ubiquitination-and-degradation
#12
Song-Hui Xu, Song Zhu, Yanjie Wang, Jin-Zhou Huang, Min Chen, Qing-Xia Wu, Yu-Tian He, De Chen, Guang-Rong Yan
The human ortholog of the Drosophila ecdysoneless gene (ECD) is required for embryonic development and cell-cycle progression; however, its role in cancer progression and metastasis remains unclear. Here, we found that ECD is frequently overexpressed in gastric cancer (GC), especially in metastatic GC, and is correlated with poor clinical outcomes in GC patients. Silencing ECD inhibited GC migration and invasion in vitro and metastasis in vivo, while ECD overexpression promoted GC migration and invasion. ECD promoted GC invasion and metastasis by protecting hnRNP F from ubiquitination and degradation...
April 30, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29705397/autocrine-ccl5-promotes-tumor-progression-in-esophageal-squamous-cell-carcinoma-in-vitro
#13
Yi-Cheng Wu, Yung-Chi Shen, John Wen-Cheng Chang, Jia-Juan Hsieh, Yen Chu, Cheng-Hsu Wang
The pro-tumoral effects of CCL5 have been identified in numerous cancer types. We successfully cultivated 4 esophageal squamous cell carcinoma (ESCC) cell lines, including TWES-1, TWES-3 and a pair of cell lines derived from primary lesion (TWES-4PT) and metastatic lymph node (TWES-4LN) of the same patient. Whole genome screening showed that TWES-4LN expressed higher levels of CCL5 compared to that of TWES-4PT; quantification of protein secretion displayed comparable results, suggesting that CCL5 could be associated with lymph node metastasis in ESCC...
April 26, 2018: Cytokine
https://www.readbyqxmd.com/read/29704239/cd97-promotes-tumor-aggressiveness-through-the-traditional-g-protein-coupled-receptor-mediated-signaling-in-hepatocellular-carcinoma
#14
Yin Yin, Xiaoliang Xu, Junwei Tang, Wenjie Zhang, Guangyan Zhangyuan, Jie Ji, Lei Deng, Shuai Lu, Han Zhuo, Beicheng Sun
Cluster of differentiation 97 (CD97) is a member of the epidermal growth factor-seven transmembrane (EGF-TM7) family belonging to the class B G-protein-coupled receptors (GPCR). The protein affects tumor aggressiveness through its cellular ligand CD55 stimulation, and exhibits adhesive properties. Previous studies have demonstrated the involvement of CD97 in dedifferentiation, migration, invasiveness and metastasis of tumors. However, little information is currently available on the specific role of CD97 in hepatocellular carcinoma (HCC)...
April 27, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29700285/hoxa4-down-regulated-in-lung-cancer-inhibits-the-growth-motility-and-invasion-of-lung-cancer-cells
#15
Shaofei Cheng, Fengying Qian, Qin Huang, Lirong Wei, Yawen Fu, Yuzhen Du
The involvement of HOXA4 in colorectal cancer and epithelial ovarian cancer has been reported. Although it has been reported that the Hoxa4 gene is involved in the patterning of the mouse lung during embryonic development, little is known about the biological functions of HOXA4 in lung cancer. In the current study, HOXA4 expression was down-regulated in lung cancer tissues when compared with non-cancerous tissues. HOXA4 expression was associated with tumor size, TNM stage, lymph node metastasis and prognosis...
April 27, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29698783/potential-role-of-nucleoside-diphosphate-kinase-in-myricetin-induced-selective-apoptosis-in-colon-cancer-hct-15-cells
#16
Jeong Hyun Lee, Yong Jun Choi, See-Hyoung Park, Myeong Jin Nam
The flavonoid myricetin (MYR) is derived from vegetables and fruits. It has been shown to exert anti-cancer effects in various cell lines; however, the exact mechanism underlying these effects is yet to be elucidated. In this study, we evaluated the anti-cancer effects induced by MYR treatment in colon cancer HCT-15 cells. To detect cell proliferation, we conducted MTT assay and real time-cell electronic sensing (RT-CES). We next performed comet assay and Annexin V and PI staining to detect cellular apoptotic features...
April 23, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29693179/mir%C3%A2-30a-inhibits-epithelial%C3%A2-mesenchymal-transition-and-metastasis-in-triple%C3%A2-negative-breast-cancer-by-targeting-ror1
#17
Xin Wang, Huisi Qiu, Ruiming Tang, Huisheng Song, Huilin Pan, Zhengfu Feng, Longhua Chen
Triple‑negative breast cancer (TNBC) is a highly aggressive breast cancer subtype that lacks effective targeted therapies. In the present study, we revealed that the expression of miR‑30a was significantly decreased in TNBC, and TNBC patients with low expression of miR‑30a were associated with high histological grade and more lymph node metastasis. Moreover, we found that miR‑30a suppressed TNBC cell epithelial‑mesenchymal transition (EMT), as demonstrated by the overexpression of miR‑30a which increased the expression of epithelial marker E‑cadherin but decreased the expression of mesenchymal markers N‑cadherin and vimentin...
April 18, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29693123/mir%C3%A2-29a%C3%A2-3p-represses-proliferation-and-metastasis-of-gastric-cancer-cells-via-attenuating-has3-levels
#18
Feihu Bai, Mengna Jiu, Yanjie You, Yaning Feng, Ruijuan Xin, Xiaogang Liu, Lirong Mo, Yongzhan Nie
MicroRNA‑29a (miR‑29a) has recently been in the spotlight as a tumor suppressor whose encoding gene is frequently suppressed in cancers. The aim of the present study was to investigate the biological functions and underlying molecular mechanism by which miR‑29a‑3p suppresses gastric cancer peritoneum metastasis. Cell proliferation, colony‑forming, wound healing and Transwell migration assays were performed in the present study. MiR‑29a‑3p expression was markedly decreased in gastric cancer cell lines with stronger metastatic potential...
April 19, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29693120/microrna%C3%A2-122-acts-as-tumor-suppressor-by-targeting-trim29-and-blocking-the-activity-of-pi3k-akt-signaling-in-nasopharyngeal-carcinoma-in-vitro
#19
Yan Yang, Qing Li, Lili Guo
Nasopharyngeal carcinoma (NPC) is endemic in the southern provinces of China and Southeast Asia. It has been reported that microRNA‑122 (miR‑122) and tripartite motif‑containing protein 29 (TRIM29) serve important roles in many types of tumor. The present study aimed to evaluate the expression of miR‑122 and TRIM29, and their clinical significance in NPC, and to examine the associated molecular mechanisms. It was observed that low expression of miR‑122 and high expression of TRIM29 led to a low overall survival rate in patients with NPC, which was associated with tumor‑node‑metastasis (TNM) stage and distant metastasis of NPC...
April 19, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29689273/melatonin-inhibits-osteosarcoma-stem-cells-by-suppressing-sox9-mediated-signaling
#20
Hao Qu, Yue Xue, Wenwen Lian, Cong Wang, Jia He, Qihong Fu, Lijia Zhong, Nong Lin, Lihua Lai, Zhaoming Ye, Qingqing Wang
AIMS: Melatonin (N-acetyl-5-methoxytryptamine) has been reported to suppress epithelial-mesenchymal transition and cancer stem cells in some types of cancer. However, the effects of melatonin on the osteosarcoma stem cells, epithelial-mesenchymal transition and metastasis of osteosarcoma are still not clear. The present study was conducted to dissect the activity of melatonin on the osteosarcoma stem cells and the underlying mechanisms. MAIN METHODS: MTT, wound healing, transwell assay and western blotting were conducted to determine the effect of melatonin on osteosarcoma cell invasion and migration and downregulation of SOX9-mediated signaling...
April 21, 2018: Life Sciences
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