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Collective migration metastasis

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https://www.readbyqxmd.com/read/27925179/hepatoma-cell-functions-modulated-by-nek2-are-associated-with-liver-cancer-progression
#1
Sheng-Ming Wu, Syuan-Ling Lin, Kang-Yun Lee, Hsiao-Chi Chuang, Po-Hao Feng, Wan-Li Cheng, Chia-Jung Liao, Hsiang-Cheng Chi, Yang-Hsiang Lin, Chung-Ying Tsai, Wei-Jan Chen, Chau-Ting Yeh, Kwang-Huei Lin
NEK2 (NIMA-related expressed kinase 2) is a serine/threonine centrosomal kinase that acts as a critical regulator of centrosome structure and function. Aberrant NEK2 activities lead to failure in regulating centrosome duplication. NEK2 overexpression promotes tumorigenesis and is associated with poor prognosis in several cancers. Increased NEK2 expression during the late pathological stage has been detected in the Oncomine liver dataset and hepatocellular carcinoma (HCC) specimens. Elevated NEK2 protein is associated with poor overall survival in patients with HCC...
December 7, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27911862/overexpression-of-semaphorin-3e-enhances-pancreatic-cancer-cell-growth-and-associates-with-poor-patient-survival
#2
Lin-Kin Yong, Syeling Lai, Zhengdong Liang, Ethan Poteet, Fengju Chen, George van Buren, William Fisher, Qianxing Mo, Changyi Chen, Qizhi Yao
Semaphorin-3E (Sema3E) is a member of an axon guidance gene family, and has recently been reported to contribute to tumor progression and metastasis. However, its role in pancreatic cancer is yet unknown and uncharacterized. In this study, we showed that Sema3E is overexpressed in human pancreatic cancer, and that high Sema3E levels are associated with tumor progression and poor survival. Interestingly, we also observed Sema3E expression in the nucleus, even though Sema3E is reported to be a secreted protein...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27902969/rac1-gtp-ase-signals-wnt-beta-catenin-pathway-mediated-integrin-directed-metastasis-associated-tumor-cell-phenotypes-in-triple-negative-breast-cancers
#3
Pradip De, Jennifer H Carlson, Tyler Jepperson, Scooter Willis, Brian Leyland-Jones, Nandini Dey
The acquisition of integrin-directed metastasis-associated (ID-MA) phenotypes by Triple-Negative Breast Cancer (TNBC) cells is caused by an upregulation of the Wnt-beta-catenin pathway (WP). We reported that WP is one of the salient genetic features of TNBC. RAC-GTPases, small G-proteins which transduce signals from cell surface proteins including integrins, have been implicated in tumorigenesis and metastasis by their role in essential cellular functions like motility. The collective percentage of alteration(s) in RAC1 in ER+ve BC was lower as compared to ER-ve BC (35% vs 57%) (brca/tcga/pub2015)...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27895497/microrna-9-suppresses-the-growth-migration-and-invasion-of-malignant-melanoma-cells-via-targeting-nrp1
#4
Dan Xu, Xiaofeng Chen, Quanyong He, Chengqun Luo
MicroRNAs (miRs) are a class of small noncoding RNAs that negatively regulate the gene expression by directly binding to the 3' untranslated region of their target mRNA, thus resulting in mRNA degradation or translational repression. miR-9 has recently been demonstrated to play a role in the development and progression of malignant melanoma (MM), but the regulatory mechanism of miR-9 in the malignant phenotypes of MM still remains largely unknown. In this study, a total of 73 pairs of MM tissues and adjacent normal tissues were collected...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27886379/supernatants-of-adipocytes-from-obese-vs-normal-weight-women-and-breast-cancer-cells-in-vitro-impact-on-angiogenesis
#5
L Bougaret, L Delort, H Billard, C Lequeux, N Goncalves-Mendes, A Mojallal, O Damour, M-P Vasson, F Caldefie-Chezet
Breast cancer is correlated with a higher risk of metastasis in obese postmenopausal women. Adipokines, whose plasma concentrations are modulated in obese subjects, surrounds mammary cells, suggesting that adipocyte secretions affect mammary tumorogenesis. We hypothsesis that matures adipocytes secretions from obese women conditioned or not by breast neoplasic cells, increase changes on the stages of angiogenesis. Supernatants of human matures adipocytes differentiated from stem cells of either adipose tissue of normal weight (MA20) or obese (MA30) women or obtained from co-cultures between MA20 or MA30 and breast cancer cell line MCF-7 were collected...
November 25, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27882343/proapoptotic-protein-bim-attenuates-estrogen-enhanced-survival-in-lymphangioleiomyomatosis
#6
Chenggang Li, Na Li, Xiaolei Liu, Erik Y Zhang, Yang Sun, Kouhei Masuda, Jing Li, Julia Sun, Tasha Morrison, Xiangke Li, Yuanguang Chen, Jiang Wang, Nagla A Karim, Yi Zhang, John Blenis, Mauricio J Reginato, Elizabeth P Henske, Jane J Yu
Lymphangioleiomyomatosis (LAM) is a progressive lung disease that primarily affects young women. Genetic evidence suggests that LAM cells bearing TSC2 mutations migrate to the lungs, proliferate, and cause cystic remodeling. The female predominance indicates that estrogen plays a critical role in LAM pathogenesis, and we have proposed that estrogen promotes LAM cell metastasis by inhibition of anoikis. We report here that estrogen increased LAM patient-derived cells' resistance to anoikis in vitro, accompanied by decreased accumulation of the proapoptotic protein Bim, an activator of anoikis...
November 17, 2016: JCI Insight
https://www.readbyqxmd.com/read/27878287/pdk1-promotes-tumor-cell-proliferation-and-migration-by-enhancing-the-warburg-effect-in-non-small-cell-lung-cancer
#7
Tao Liu, Honglei Yin
Tumor cells prefer glycolysis (Warburg effect) during the proliferation and metastasis. The precise mechanism remains largely unknown. Here, we demonstrated that pyruvate dehydrogenase kinase 1 (PDK1) was a critical enzyme that functioned as an oncogene to promote non-small cell lung cancer (NSCLC) growth and metastasis. We discovered that PDK1 expression was significantly upregulated in NSCLC tissues and correlated with advanced T stage. Moreover, high expression of PDK1 was an independent prognostic factor of NSCLC...
November 16, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27864346/cbx4-suppresses-metastasis-via-recruitment-of-hdac3-to-the-runx2-promoter-in-colorectal-carcinoma
#8
Xin Wang, Liping Li, Yuanzhong Wu, Ruhua Zhang, Meifang Zhang, Dan Liao, Gang Wang, Ge Qin, Rui-Hua Xu, Tiebang Kang
Polycomb chromobox (CBX) proteins participate in the polycomb repressive complex (PRC1) that mediates epigenetic gene silencing and endow PRC1 with distinct oncogenic or tumor suppressor functions in a cell type-dependent manner. In this study, we report that inhibition of cell migration, invasion, and metastasis in colorectal carcinoma (CRC) requires CBX4-mediated repression of Runx2, a key transcription factor that promotes CRC metastasis. CBX4 inversely correlated with Runx2 expression in CRC tissues, and the combination of high CBX4 expression and low Runx2 expression significantly correlated with overall survival, more so than either CBX4 or Runx2 expresson alone...
November 18, 2016: Cancer Research
https://www.readbyqxmd.com/read/27863122/modeling-signaling-and-cytoskeleton-dynamics-integrated-modeling-experimental-frameworks-in-cell-migration
#9
REVIEW
Meng Sun, Muhammad H Zaman
Cell migration is a complex and multistep process involved in homeostasis maintenance, morphogenesis, and disease development, such as cancer metastasis. Modeling cell migration and the relevant cytoskeleton dynamics have profound implications for studying fundamental development and disease diagnosis. This review focuses on some recent models of both cell migration and migration-related cytoskeleton dynamics, addressing issues such as the difference between amoeboid and mesenchymal migration modes, and between single-cell migration and collective cell migration...
November 15, 2016: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/27837347/tamoxifen-resistance-and-metastasis-of-human-breast-cancer-cells-were-mediated-by-the-membrane-associated-estrogen-receptor-er-%C3%AE-36-signaling-in-vitro
#10
Wenwen Gu, Nian Dong, Peng Wang, Changgen Shi, Jun Yang, Jian Wang
The drug resistance and tumor metastasis have been the main obstacles for the longer-term therapeutic effects of tamoxifen (TAM) on estrogen receptor-positive (ER(+)) breast cancer, but the mechanisms underlying the TAM resistance are still unclear. Here, we demonstrated that the membrane-associated estrogen receptor ER-α36 signaling, but not the G protein-coupled estrogen receptor 1 (GPER1) signaling, might be involved in the TAM resistance and metastasis of breast cancer cells. In this study, a model of ER(+) breast cancer cell MCF-7 that involves the up-regulated expression of ER-α36 and unchanged expression of ER-α66 and GPER1 was established via the removal of insulin from the cell culture medium...
November 11, 2016: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/27835600/yap1-enhances-cell-proliferation-migration-and-invasion-of-gastric-cancer-in-vitro-and-in-vivo
#11
Dan Sun, Xiaoting Li, Yingjian He, Wenhui Li, Ying Wang, Huan Wang, Shanshan Jiang, Yan Xin
Yes-associated protein 1 (YAP1) plays an important role in the development of carcinomas such as breast, colorectal, and gastric (GC) cancers, but the role of YAP1 in GC has not been investigated comprehensively. The present study strongly suggests that YAP1 and P62 were significantly up-regulated in GC specimens, compared with normal gastric mucosa. In addition, the YAP1high P62high expression was independently associated with poor prognosis in GC (hazard ratio: 1.334, 95% confidence interval: 1.045-1.704, P = 0...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27829995/long-noncoding-rna-zeb1-as1-acts-as-an-oncogene-in-osteosarcoma-by-epigenetically-activating-zeb1
#12
Chibo Liu, Jianjun Lin
Long noncoding RNAs (lncRNAs) have been demonstrated to be dysregulated in many disease states and have pivotal roles in various pathophysiological processes. However, the expression, roles and potential mechanism of lncRNA ZEB1-AS1 in osteosarcoma are still unknown. In this study, we measured ZEB1-AS1 expression and the results showed that ZEB1-AS1 was upregulated in osteosarcoma tissues and cells. Increased expression of ZEB1-AS1 is correlated with larger tumor size, progressed Enneking stage, tumor metastasis, worse recurrence-free and overall survival of osteosarcoma patients...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27826898/collective-cell-migration-of-thyroid-carcinoma-cells-a-beneficial-ability-to-override-unfavourable-substrates
#13
Liudmila Lobastova, Dominik Kraus, Alexander Glassmann, Dilaware Khan, Christian Steinhäuser, Christina Wolff, Nadine Veit, Jochen Winter, Rainer Probstmeier
PURPOSE: Tumor cell invasion and metastasis are life threatening events. Invasive tumor cells tend to migrate as collective sheets. In the present in vitro study we aimed to (i) assess whether collective tumor cells gain benefits in their migratory potential compared to single cells and (ii) to identify its putative underlying molecular mechanisms. METHODS: The migratory potential of single and collective carcinoma cells was assessed using video time lapse microscopy and cell migration assays in the absence and presence of seven potential gap junction inhibitors or the Rac1 inhibitor Z62954982...
November 8, 2016: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/27821145/pathologically-decreased-expression-of-mir-193a-contributes-to-metastasis-by-targeting-wt1-e-cadherin-axis-in-non-small-cell-lung-cancers
#14
Junjie Chen, Shenmeng Gao, Chunjing Wang, Zhonggai Wang, Huxiang Zhang, Kate Huang, Bin Zhou, Haiying Li, Zhijie Yu, Jianbo Wu, Chengshui Chen
BACKGROUND: The metastatic cascade is a complex and multistep process with many potential barriers. Recently, miR-193a has been reported to be a suppressive miRNA in multiple types of cancers, but its underlying anti-oncogenic activity in non-small cell lung cancers (NSCLC) is not fully elucidated. METHODS: The expressions of miR-193a (miR-193a-5p) in human lung cancer tissues and cell lines were detected by real-time PCR. Dual-luciferase reporter assay was used to identify the direct target of miR-193a...
November 7, 2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27819668/sall4-promotes-gastric-cancer-progression-through-activating-cd44-expression
#15
X Yuan, X Zhang, W Zhang, W Liang, P Zhang, H Shi, B Zhang, M Shao, Y Yan, H Qian, W Xu
The stem cell factor SALL4 (Sal-like protein 4) plays important roles in the development and progression of cancer. SALL4 is critically involved in tumour growth, metastasis and therapy resistance. However, the underlying mechanisms responsible for the oncogenic roles of SALL4 have not been well characterized. In this study, we demonstrated that SALL4 knockdown by short hairpin RNA greatly inhibited the proliferation, migration and invasion of gastric cancer cells. We further confirmed the inhibitory effects of SALL4 knockdown on gastric cancer cells by using a tetracycline-inducible system...
November 7, 2016: Oncogenesis
https://www.readbyqxmd.com/read/27814431/the-mechanics-of-single-cell-and-collective-migration-of-tumor-cells
#16
Marianne Lintz, Adam Muñoz, Cynthia A Reinhart-King
Metastasis is a dynamic process in which cancer cells navigate the tumor microenvironment, largely guided by external chemical and mechanical cues. Our current understanding of metastatic cell migration has relied primarily on studies of single cell migration, most of which have been performed using two-dimensional cell culture techniques and, more recently, using three-dimensional scaffolds. However, the current paradigm focused on single cell movements is shifting towards the idea that collective migration is likely one of the primary modes of migration during metastasis of many solid tumors...
November 4, 2016: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/27813495/lentivirus-mediated-rnai-knockdown-of-insulin-like-growth-factor-1-receptor-inhibits-the-growth-and-invasion-of-hepatocellular-carcinoma-via-down-regulating-midkine-expression
#17
Cai Qun Bie, Xu You Liu, Ming Rong Cao, Qiu Yan Huang, Hui Jun Tang, Min Wang, Guo Li Cao, Ting Zhuang Yi, Sheng Lan Wu, Wei Jie Xu, Shao Hui Tang
The insulin-like growth factor-1 receptor (IGF-1R) overexpression contributes to the development of a variety of cancers. The present study explored the role of IGF-1R in the development and progression of hepatocellular carcinoma (HCC) and the possibility of IGF-1R silencing by lentivirus-mediated RNA interference (RNAi) as a therapeutic target for HCC. We showed that IGF-1R mRNA was up-regulated in Huh7 and Hep3B cells and human HCC tissues, and that IGF-1R knockdown by RNAi led to decreased proliferation, apoptosis induction, and decreased migration and invasion of Huh7 and Hep3B cells...
November 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27811365/syntenin-1-is-a-promoter-and-prognostic-marker-of-head-and-neck-squamous-cell-carcinoma-invasion-and-metastasis
#18
Li Cui, Siliangyu Cheng, Xiaojun Liu, Diana Messadi, Yan Yang, Shen Hu
Metastasis represents a key factor associated with poor prognosis of head and neck squamous cell carcinoma (HNSC). However, the underlying molecular mechanisms remain largely unknown. In this study, our liquid chromatography with tandem mass spectrometry analysis revealed a number of significantly differentially expressed membrane/membrane-associated proteins between high invasive UM1 and low invasive UM2 cells. One of the identified membrane proteins, Syntenin-1, was remarkably up-regulated in HNSC tissues and cell lines when compared to the controls, and also over-expressed in recurrent HNSC and high invasive UM1 cells...
November 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27808120/ethanol-extract-of-lophatheri-herba-exhibits-anti-cancer-activity-in-human-cancer-cells-by-suppression-of-metastatic-and-angiogenic-potential
#19
Aeyung Kim, Minju Im, Min Jung Gu, Jin Yeul Ma
Lophatheri Herba (LH), dried leaf of Lophatherum gracile Brongn, has long been used to reduce thirst and treat fever and inflammation in Chinese medicine. Recent studies have shown that LH has anti-viral, anti-bacterial, anti-cancer, anti-oxidant, diuretic, and hyperglycemic properties. However, the effects of an ethanol extract of L. herba (ELH), at non-cytotoxic doses, on the metastatic and angiogenic abilities of malignant tumor cells have not been reported. We found that ELH significantly suppressed p38, JNK, and NF-κB activation and proteolytic activities under phorbol 12-myristate 13-acetate (PMA) stimulation, thus leading to a decrease in metastatic potential, including migration and invasion...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27784747/mechanisms-through-which-hypoxia-induced-caveolin-1-drives-tumorigenesis-and-metastasis-in-hepatocellular-carcinoma
#20
Xiaowen Mao, Sivia Ys Wong, Edith Yt Tse, Frankie Chi-Fat Ko, Sze Keong Tey, Yin Shan Yeung, Kwan Man, Regina Cheuk-Lam Lo, Irene Oi-Lin Ng, Judy Wp Yam
In solid tumors, hypoxia triggers an aberrant vasculogenesis, enhances malignant character and elevates metastatic risk. The plasma membrane organizing protein caveolin-1 (Cav1) is increased in a variety of cancers including hepatocellular carcinoma (HCC) where it is contributes to metastatic capability. However, the reason for elevation of Cav1 in tumor cells and the mechanistic basis for its contributions to metastatic risk are not fully understood. Here we show that in HCC cells hypoxia elevates expression of Cav1, which then acts through the calcium binding protein S100P to promote metastasis...
October 26, 2016: Cancer Research
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