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https://www.readbyqxmd.com/read/29156520/long-noncoding-rna-linc00961-inhibits-cell-invasion-and-metastasis-in-human-non-small-cell-lung-cancer
#1
Bin Jiang, Jing Liu, Yu-Hong Zhang, Dong Shen, Shaoping Liu, Feng Lin, Jun Su, Qing-Feng Lin, Shuai Yan, Yong Li, Wei-Dong Mao, Zhi-Li Liu
Long noncoding RNAs (LncRNAs) expression has been found to be misregulated in multiple human cancers, and a growing number of studies have revealed that lncRNAs can function as important oncogenes or tumor suppressors. In this study, we identified a lncRNA-LINC00961, which was significantly down-regulated in human non-small cell lung cancer tissues. Decreased LINC00961 was associated with NSCLC patients advanced clinical stage, lymph node metastasis, and shorter survival time. Further experiments demonstrated that LSD1 could directly bind to LINC00961 promoter regions and epigenetically repress its transcription in NSCLC cells...
November 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29145972/cancer-immunotherapy-getting-brainy-visualizing-the-distinctive-cns-metastatic-niche-to-illuminate-therapeutic-resistance
#2
Mark Owyong, Niloufar Hosseini-Nassab, Gizem Efe, Alexander Honkala, Renske J E van den Bijgaart, Vicki Plaks, Bryan Ronain Smith
The advent of cancer immunotherapy (CIT) and its success in treating primary and metastatic cancer may offer substantially improved outcomes for patients. Despite recent advancements, many malignancies remain resistant to CIT, among which are brain metastases, a particularly virulent disease with no apparent cure. The immunologically unique niche of the brain has prompted compelling new questions in immuno-oncology such as the effects of tissue-specific differences in immune response, heterogeneity between primary tumors and distant metastases, and the role of spatiotemporal dynamics in shaping an effective anti-tumor immune response...
November 2017: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://www.readbyqxmd.com/read/29142217/fbxo32-promotes-microenvironment-underlying-epithelial-mesenchymal-transition-via-ctbp1-during-tumour-metastasis-and-brain-development
#3
Sanjeeb Kumar Sahu, Neha Tiwari, Abhijeet Pataskar, Yuan Zhuang, Marina Borisova, Mustafa Diken, Susanne Strand, Petra Beli, Vijay K Tiwari
The set of events that convert adherent epithelial cells into migratory cells are collectively known as epithelial-mesenchymal transition (EMT). EMT is involved during development, for example, in triggering neural crest migration, and in pathogenesis such as metastasis. Here we discover FBXO32, an E3 ubiquitin ligase, to be critical for hallmark gene expression and phenotypic changes underlying EMT. Interestingly, FBXO32 directly ubiquitinates CtBP1, which is required for its stability and nuclear retention...
November 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/29138811/high-expression-of-mage-a9-contributes-to-stemness-and-malignancy-of-human-hepatocellular-carcinoma
#4
Youping Wei, Yanqin Wang, Jing Gong, Lihua Rao, Zhiwei Wu, Teng Nie, Dongling Shi, Liming Zhang
MAGE-A9, a well-characterized cancer testis antigen (CTA), belongs to a member of melanoma antigen gene (MAGE) family. In human malignancies, aberrant expression of MAGE genes correlated with poor clinical prognosis, increased tumor growth, metastases, and enrichment in stem cell populations of certain cancers. Cancer stem cells (CSCs) have been proposed to contribute to the major malignant phenotypes of liver cancer, including recurrence, metastasis and chemoresistance. However, expression and potential role of MAGE-A9 in liver cancer stem cells (LCSCs) still remain unclear...
November 9, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29138312/correlating-cell-shape-and-cellular-stress-in-motile-confluent-tissues
#5
Xingbo Yang, Dapeng Bi, Michael Czajkowski, Matthias Merkel, M Lisa Manning, M Cristina Marchetti
Collective cell migration is a highly regulated process involved in wound healing, cancer metastasis, and morphogenesis. Mechanical interactions among cells provide an important regulatory mechanism to coordinate such collective motion. Using a self-propelled Voronoi (SPV) model that links cell mechanics to cell shape and cell motility, we formulate a generalized mechanical inference method to obtain the spatiotemporal distribution of cellular stresses from measured traction forces in motile tissues and show that such traction-based stresses match those calculated from instantaneous cell shapes...
November 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29138007/rbm4-srsf3-map4k4-splicing-cascade-modulates-the-metastatic-signature-of-colorectal-cancer-cell
#6
Jung-Chun Lin, Yuan-Chii Lee, Tse-Hua Tan, Yu-Chih Liang, Huai-Chia Chuang, Yang C Fann, Kory R Johnson, Ying-Ju Lin
Alternative splicing (AS) of pre-messenger (m)RNA is a pivotal mechanism in expanding proteomic diversity, which determines the functions of mammalian cells. By conducting transcriptome analyses to profile splicing events in human colorectal cancer (CRC) tissues compared to adjacent normal counterparts, we noted differential splicing profiles of serine/arginine-rich splicing factor 3 (SRSF3) and mitogen-activated protein 4 kinase 4 (MAP4K4) in cancerous tissues of CRC compared to adjacent normal tissues. In addition to SRSF3-mediated autoregulation, RNA-binding motif protein 4 (RBM4) constituted another mechanism in reprogramming the splicing profile of SRSF3...
November 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29137432/mir-143-inhibits-endometrial-cancer-cell-proliferation-and-metastasis-by-targeting-mapk1
#7
Lei Chang, Dongya Zhang, Huirong Shi, Yangyang Bian, Ruixia Guo
Endometrial cancer (EC) is one of the most commonly diagnosed gynecologic malignancies in the world, with the morbidity rate of over 7%. The mechanism of the pathogenesis has not been specifically elucidated to date, which is imperative for EC treatment. The aim of our study was to investigate the target relationship between miR-143 and mitogen-activated protein kinase 1 (MAPK1) and explore the effect of miR-143 on the endometrial cancers (EC) cells through targeting MAPK1. We collected EC tissues and adjacent tissues, and transfected miR-143 mimics and MAPK1 siRNA into EC cells with lipofectamine...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29131259/microrna-21-functions-as-an-oncogene-and-promotes-cell-proliferation-and-invasion-via-timp3-in-renal-cancer
#8
J Chen, Y Gu, W Shen
OBJECTIVE: Renal cell carcinoma (RCC) displays an increasing incidence and mortality rate worldwide in recent years. More and more evidence identified microRNAs function as positive or negative regulatory factors in many cancers, but the role of miR-21 in RCC remains unclear. PATIENTS AND METHODS: Relative expression levels of miR-21 in human RCC tissue samples and RCC-derived cell lines were measured using quantitative real-time Polymerase Chain Reaction (PCR)...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29115574/long-non-coding-rna-snhg1-regulates-nob1-expression-by-sponging-mir-326-and-promotes-tumorigenesis-in-osteosarcoma
#9
Jiandong Wang, Lei Cao, Jianhong Wu, Qiugen Wang
The long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) has been demonstrated to participate in the deterioration of many types of cancer. However, the underlying mechanisms of SNHG1-mediating functions in osteosarcoma (OS) have yet to be elucidated. In the present study, our results showed that SNHG1 was upregulated in OS tissues and cell lines, and high SNHG1 expression predicts poor overall survival of OS patients. Knockdown of SNHG1 inhibited cell growth and metastasis of OS in vitro and in vivo...
November 3, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29115564/mir-486-functions-as-a-tumor-suppressor-in-esophageal-cancer-by-targeting-cdk4-bcas2
#10
Baoping Lang, Song Zhao
Esophageal cancer is a common tumor for which morbidity and mortality are high worldwide. We aimed to study alterations in miR-486 expression in esophageal cancers, and the effect miR-486 on esophageal cancer cell function and behavior. We collected esophageal cancer tissues/corresponding normal tissues from 20 patients and utilized three esophageal cancer cell lines and normal esophageal epithelial cells, and the expression of miR-486, CDK4 and BCAS2 was detected by qRT-PCR. Western blotting was used to detect the expression of CDK4 and BCAS2 protein...
November 1, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29100384/cul4b-promotes-bladder-cancer-metastasis-and-induces-epithelial-to-mesenchymal-transition-by-activating-the-wnt-%C3%AE-catenin-signaling-pathway
#11
Xia-Wa Mao, Jia-Quan Xiao, Gang Xu, Zhong-Yi Li, Hui-Feng Wu, Yi Li, Yi-Chun Zheng, Nan Zhang
Increased expression of cullin 4B (CUL4B) is linked to progression in several cancers. This study aims to explore the effects of CUL4B on bladder cancer (BC) metastasis and epithelial-to-mesenchymal transition (EMT) and potential correlation to the Wnt/β-catenin signaling pathway. We collected BC tissues and adjacent normal tissues from 124 BC patients. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting were employed in order to detect the expression of Wnt/β-catenin signaling pathway-related proteins and EMT markers...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29095547/rac-gtpase-activating-protein-1-promotes-the-oncogenic-progression-of-epithelial-ovarian-cancer
#12
Chuanjiang Wang, Wenxia Wang, Yujuan Liu, Min Yong, Yamei Yang, Honggui Zhou
Rac GTPase activating protein 1 (RacGAP1) can regulate cytokinesis and cell differentiation. The oncogenic role of RacGAP1 has been partially studied in gastric cancer, colorectal cancer, and breast cancer. In this study, we endeavor to evaluate its expression and functions in epithelial ovarian cancer (EOC). We retrospectively collected the clinicopathological information of 117 patients who underwent curative surgery for EOC. The expression of RacGAP1 protein in primary tumor tissues was evaluated by immunohistochemistry, which was significantly associated with tumor pathological grade, tumor stage, and lymph node metastasis...
November 2, 2017: Cancer Science
https://www.readbyqxmd.com/read/29079416/macrophage-migration-inhibitory-factor-promotes-tumor-aggressiveness-of-esophageal-squamous-cell-carcinoma-via-activation-of-akt-and-inactivation-of-gsk3%C3%AE
#13
Rui-Min Liu, Dan-Ni Sun, Ye-Lin Jiao, Pan Wang, Juan Zhang, Ming Wang, Jin Ma, Man Sun, Bian-Li Gu, Pan Chen, Ke Liu, Heng Ma, She-Gan Gao, Yuan-Fang Ma, Yi-Jun Qi
The pleiotropic pro-inflammatory cytokine, macrophage migration inhibitory factor (MIF), represents an important link between chronic inflammation and tumorigenesis. Although accumulating evidence demonstrates that MIF overexpression is implicated in the development and progression of multiple cancers, including esophageal squamous cell carcinoma (ESCC), the molecular mechanisms underlying its tumor-promoting roles in ESCC remain unclear. In the present study, we observed that MIF is overexpressed in ESCC and correlated significantly with lymph node metastasis, advanced clinical stage, and poor survival of ESCC...
October 25, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29075791/anticancer-effects-of-methanol-extract-of-myrmecodia-platytyrea-becc-leaves-against-human-hepatocellular-carcinoma-cells-via-inhibition-of-erk-and-stat3-signaling-pathways
#14
Anna Ju, Young-Chang Cho, Ba Reum Kim, Sewoong Lee, Hien Thi Thu Le, Huong Lan Vuong, Sayeon Cho
Myrmecodia platytyrea Becc., a member of the Rubiaceae family, is found throughout Southeast Asia and has been traditionally used to treat cancer. However, there is limited pharmacological information on this plant. We investigated the anticancer effects of the methanol extract of Myrmecodia platytyrea Becc. leaves (MMPL) and determined the molecular mechanisms underlying the effects of MMPL on metastasis in human hepatocellular carcinoma (HCC) cells. MMPL dose-dependently inhibited cell migration and invasion in SK‑Hep1 and Huh7 cells...
October 24, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29075149/the-role-of-mir-485-5p-nudt1-axis-in-gastric-cancer
#15
Jingjing Duan, Haiyang Zhang, Shuang Li, Xinyi Wang, Haiou Yang, Shunchang Jiao, Yi Ba
BACKGROUND: Cancers can survive the oxidative conditions by upregulating nucleoside diphosphate linked moiety X-type motif 1 (NUDT1). However, the mechanisms underlying gastric carcinogenesis and the dys-regulation of NUDT1 in gastric cancer (GC) remain unknown. Our study aimed to explore the role of NUDT1 and its regulatory pathway by miR-485-5p in GC. METHODS: Gastric cancer tissues and paired noncancerous tissue samples were collected, and the expression level of NUDT1 and miR-485-5p were detected...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29058818/prognostic-significance-of-long-non-coding-rna-malat1-for-predicting-the-recurrence-and-metastasis-of-gallbladder-cancer-and-its-effect-on-cell-proliferation-migration-invasion-and-apoptosis
#16
Ke-Ke Sun, Ping-Ping Hu, Feng Xu
The objective of this study is to explore the role of MALAT1 as a molecular indicator in predicting the recurrence, metastasis and prognosis of gallbladder cancer (GBC) and its effect on the proliferation, invasion, migration, and apoptosis of GBC cells in vitro. GBC tissues and adjacent normal tissues were collected from 102 patients. MALAT1 short hairpin RNA (shRNA) plasmids were first constructed to transfect the GBC-SD cells. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was applied to detect MALAT1 expression...
October 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29058718/pkm2-methylation-by-carm1-activates-aerobic-glycolysis-to-promote-tumorigenesis
#17
Fabao Liu, Fengfei Ma, Yuyuan Wang, Ling Hao, Hao Zeng, Chenxi Jia, Yidan Wang, Peng Liu, Irene M Ong, Baobin Li, Guojun Chen, Jiaoyang Jiang, Shaoqin Gong, Lingjun Li, Wei Xu
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of metabolism from oxidative phosphorylation to aerobic glycolysis in breast cancer cells. Oxidative phosphorylation depends on mitochondrial calcium concentration, which becomes critical for cancer cell survival when PKM2 methylation is blocked...
November 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/29050254/rgs19-upregulates-nm23-h1-2-metastasis-suppressors-by-transcriptional-activation-via-the-camp-pka-creb-pathway
#18
Yuanjun Li, Jiaxing Song, Yao Tong, Sookja Kim Chung, Yung H Wong
The Nm23 metastasis suppressor family is involved in physiological and pathological processes including tumorigenesis and metastasis. Although the inverse correlation of Nm23 level with tumor metastasis potential has been widely observed, the mechanisms that regulate the expression of Nm23 remain poorly understood. Our previous studies have revealed that Nm23-H1/2 isoforms are upregulated by RGS19, a regulator of G protein signaling (RGS) protein which accelerates the termination of Gi signals. Here, we examined the ability of RGS19 to stimulate transcriptional regulation of Nm23 by screening a panel of luciferase reporter genes...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29048641/baicalein-inhibits-tumor-progression-by-inhibiting-tumor-cell-growth-and-tumor-angiogenesis
#19
Yang-Gyu Park, Jawun Choi, Hye-Kang Jung, Bumseok Kim, Chan Kim, Sang-Youel Park, Jae-Won Seol
Baicalein, a herbal medicine, is a natural flavonoid isolated from the roots of Scutellaria baicalensis Georgi. It is known for its anticancer, anti-inflammatory and neuroprotective properties. Despite these well-known properties, it is not yet clear what effect baicalein has on tumor progression. Therefore, in the present study, we used B16F10 cells, Lewis lung carcinoma (LLC) cells, and human umbilical vein endothelial cells (HUVECs) to investigate the effect of baicalein on cell proliferation and viability, migration and tube formation in vitro...
September 26, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29043215/inhibitory-effect-of-hizikia-fusiformis-solvent-partitioned-fractions-on-invasion-and-mmp-activity-of-ht1080-human-fibrosarcoma-cells
#20
Seul-Gi Lee, Fatih Karadeniz, Jung Hwan Oh, Ga Hyun Yu, Chang-Suk Kong
Matrix metalloproteinases (MMPs) are endopeptidases that take significant roles in extracellular matrix degradation and therefore linked to several complications such as metastasis of cancer progression, oxidative stress, and hepatic fibrosis. Hizikia fusiformis, a brown algae, was reported to possess bioactivities, including but not limited to, antiviral, antimicrobial, and anti-inflammatory partly due to bioactive polysaccharide contents. In this study, the potential of H. fusiformis against cancer cell invasion was evaluated through the MMP inhibitory effect in HT1080 fibrosarcoma cells in vitro...
September 2017: Preventive Nutrition and Food Science
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