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https://www.readbyqxmd.com/read/28926939/kempopeptin-c-a-novel-marine-derived-serine-protease-inhibitor-targeting-invasive-breast-cancer
#1
Fatma H Al-Awadhi, Lilibeth A Salvador, Brian K Law, Valerie J Paul, Hendrik Luesch
Kempopeptin C, a novel chlorinated analogue of kempopeptin B, was discovered from a marine cyanobacterium collected from Kemp Channel in Florida. The structure was elucidated using NMR spectroscopy and mass spectrometry (MS). The presence of the basic Lys residue adjacent to the N-terminus of the 3-amino-6-hydroxy-2-piperidone (Ahp) moiety contributed to its selectivity towards trypsin and related proteases. The antiproteolytic activity of kempopeptin C was evaluated against trypsin, plasmin and matriptase and found to inhibit these enzymes with IC50 values of 0...
September 16, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28923134/%C3%A3-1-3-galactosyl-o-glycosyl-glycoprotein-%C3%A3-1-6-n-acetylglucosaminyltransferase-3-increases-mcam-stability-which-enhances-s100a8-a9-mediated-cancer-motility
#2
I Wayan Sumardika, Chen Youyi, Eisaku Kondo, Yusuke Inoue, I Made Winarsa Ruma, Hitoshi Murata, Rie Kinoshita, Ken-Ichi Yamamoto, Shuta Tomida, Kazuhiko Shien, Hiroki Satoh, Akira Yamauchi, Junichiro Futami, Endy Widya Putranto, Toshihiko Hibino, Shinichi Toyooka, Masahiro Nishibori, Masakiyo Sakaguchi
We previously identified novel S100A8/A9 receptors, Extracellular Matrix Metalloproteinase Inducer (EMMPRIN), MelanomaCell Adhesion Molecule (MCAM), Activated Leukocyte Cell Adhesion Molecule (ALCAM) and Neuroplastin (NPTN) ß, that are critically involved in S100A8/A9-mediated cancer metastasis and inflammation when expressed at high levels. However, little is known about the presence of any cancerspecific mechanism(s) that modifies these receptors, further inducing upregulation at protein levels without any transcriptional regulation...
September 18, 2017: Oncology Research
https://www.readbyqxmd.com/read/28918264/past-matrix-stiffness-primes-epithelial-cells-and-regulates-their-future-collective-migration-through-a-mechanical-memory
#3
Samila Nasrollahi, Christopher Walter, Andrew J Loza, Gregory V Schimizzi, Gregory D Longmore, Amit Pathak
During morphogenesis and cancer metastasis, grouped cells migrate through tissues of dissimilar stiffness. Although the influence of matrix stiffness on cellular mechanosensitivity and motility are well-recognized, it remains unknown whether these matrix-dependent cellular features persist after cells move to a new microenvironment. Here, we interrogate whether priming of epithelial cells by a given matrix stiffness influences their future collective migration on a different matrix - a property we refer to as the 'mechanical memory' of migratory cells...
September 8, 2017: Biomaterials
https://www.readbyqxmd.com/read/28915533/long-non-coding-rna-malat1-promotes-proliferation-and-invasion-via-targeting-mir-129-5p-in-triple-negative-breast-cancer
#4
Yonggang Zuo, Yue Li, Zhenyu Zhou, Mingde Ma, Kanda Fu
BACKGROUND: Long non-coding RNA Metastasis associated lung adenocarcinoma transcript 1(lncRNA MALAT1) play important roles in tumor progression. In the present study, we determined the regulatory function of MALAT1 in triple-negative breast cancer (TNBC). METHODS: A total of 43 cases of TNBC tissues and paired adjacent non-tumor tissues were collected for the research. MALAT1 expression was explored by qRT-PCR. In vitro functional validation experiments were used to determine the effect of MALAT1 on TNBC progression...
September 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28912898/inhibition-of-bone-marrow-derived-mesenchymal-stem-cells-homing-towards-triple-negative-breast-cancer-microenvironment-using-an-anti-pdgfr%C3%AE-aptamer
#5
Simona Camorani, Billy Samuel Hill, Raffaela Fontanella, Adelaide Greco, Matteo Gramanzini, Luigi Auletta, Sara Gargiulo, Sandra Albanese, Enrico Lucarelli, Laura Cerchia, Antonella Zannetti
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are shown to participate in tumor progression by establishing a favorable tumor microenvironment (TME) that promote metastasis through a cytokine networks. However, the mechanism of homing and recruitment of BM-MSCs into tumors and their potential role in malignant tissue progression is poorly understood and controversial. Here we show that BM-MSCs increase aggressiveness of triple-negative breast cancer (TNBC) cell lines evaluated as capability to migrate, invade and acquire stemness markers...
2017: Theranostics
https://www.readbyqxmd.com/read/28912889/cbx8-suppresses-tumor-metastasis-via-repressing-snail-in-esophageal-squamous-cell-carcinoma
#6
Gang Wang, Jianjun Tang, Weixiang Zhan, Ruhua Zhang, Meifang Zhang, Dan Liao, Xin Wang, Yuanzhong Wu, Tiebang Kang
The poor clinical outcome and prognosis of esophageal squamous cell carcinoma (ESCC) is mainly attributed to its highly invasive and metastatic nature, making it urgent to further elicit the molecular mechanisms of the metastasis of ESCC. The function of each polycomb chromobox (CBX) protein in cancer is cell-type-dependent. Although CBX8 has been reported to promote the esophageal squamous cell carcinoma (ESCC) tumorigenesis, its role in ESCC metastasis has not been explored yet. In this study, we report that the inhibition of cell migration, invasion, and metastasis in ESCC requires CBX8-mediated repression of Snail, a key transcription factor that induces epithelial-to-mesenchymal transition (EMT), and that CBX8 inversely correlated with Snail in the ESCC tissues...
2017: Theranostics
https://www.readbyqxmd.com/read/28903319/loss-of-giant-obscurins-alters-breast-epithelial-cell-mechanosensing-of-matrix-stiffness
#7
Kimberly M Stroka, Bin Sheng Wong, Marey Shriver, Jude M Phillip, Denis Wirtz, Aikaterini Kontrogianni-Konstantopoulos, Konstantinos Konstantopoulos
Obscurins are a family of RhoGEF-containing proteins with tumor and metastasis suppressing roles in breast epithelium. Downregulation of giant obscurins in normal breast epithelial cells leads to reduced levels of active RhoA and of its downstream effectors. Herein, we elucidate how depletion of giant obscurins affects the response of breast epithelial cells to changes in the mechanical properties of the microenvironment. We find that knockdown of obscurins increases cell morphodynamics, migration speed, and diffusivity on polyacrylamide gels of ≥ 1 kPa, presumably by decreasing focal adhesion area and density as well as cell traction forces...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28901479/interaction-with-neutrophils-promotes-gastric-cancer-cell-migration-and-invasion-by-inducing-epithelial-mesenchymal-transition
#8
Wen Zhang, Jianmei Gu, Jingyan Chen, Peng Zhang, Runbi Ji, Hui Qian, Wenrong Xu, Xu Zhang
Emerging evidence has revealed that neutrophils have phenotypic and functional plasticity. Neutrophils could be polarized towards a pro-tumor phenotype by tumor-derived factors. In the present study, we investigated the role of the interaction with neutrophils on the functions of gastric cancer cells in vitro. Human promyelocytic leukemia HL-60 cells were induced to differentiate into neutrophil-like cells (HL-60N) using dimethyl sulfoxide (DMSO). Human gastric cancer cells were co-cultured with HL-60N cells or treated with the conditioned medium (CM) of cancer-activated HL-60N cells...
September 6, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28900490/wnt3a-expression-is-associated-with-epithelial-mesenchymal-transition-and-impacts-prognosis-of-lung-adenocarcinoma-patients
#9
Jinming Xu, Wang Lv, Yeji Hu, Luming Wang, Yiqing Wang, Jinlin Cao, Jian Hu
Background: Epithelial-mesenchymal transition (EMT) plays an important role in the invasion and migration during cancer metastasis. Wnt3a is one of the ligands in canonical Wnt/β-catenin signaling pathway, which contributes to the carcinogenesis and progression of lung cancer cell lines. The aim of this study was to evaluate the association between Wnt3a and EMT-related proteins (E-cadherin and N-cadherin), and to further investigate its impact on prognosis of lung adenocarcinoma patients. Methods: A total of 147 lung adenocarcinoma patients were included and their clinicopathological characteristics were collected in this retrospective study...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28899455/mitotic-arrest-deficient-protein-2b-overexpressed-in-lung-cancer-promotes-proliferation-emt-and-metastasis
#10
Hua Zhang, Xiuquan He, Wenfei Yu, Bingqing Yue, Ziting Yu, Ying Qin
As the non-catalytic subunit of mammalian DNA polymerase, mitotic arrest-deficient protein 2B (MAD2B) has been reportedto play a role in cell-cycle regulation, DNA damage tolerance, gene expression and carcinogenesis. Although its expression is known to be associated with poor prognosis in several types of human cancers, the significance of MAD2B expression in lung malignancies is still unclear. Our study showed that MAD2B expression significantly increased in lung cancer, especially in the metastatic tissues...
September 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28888421/neural-crest-and-cancer-divergent-travelers-on-similar-paths
#11
REVIEW
Kristin L Gallik, Randall W Treffy, Lynne M Nacke, Kamil Ahsan, Manuel Rocha, Abigail Green-Saxena, Ankur Saxena
Neural crest cells are multipotent progenitors that dynamically interpret diverse microenvironments to migrate significant distances as a loosely associated collective and contribute to many tissues in the developing vertebrate embryo. Uncovering details of neural crest migration has helped to inform a general understanding of collective cell migration, including that which occurs during cancer metastasis. Here, we discuss several commonalities and differences of neural crest and cancer cell migration and behavior...
September 6, 2017: Mechanisms of Development
https://www.readbyqxmd.com/read/28881737/galeterone-and-its-analogs-inhibit-mnk-eif4e-axis-synergize-with-gemcitabine-impede-pancreatic-cancer-cell-migration-invasion-and-proliferation-and-inhibit-tumor-growth-in-mice
#12
Andrew K Kwegyir-Afful, Francis N Murigi, Puranik Purushottamachar, Vidya P Ramamurthy, Marlena S Martin, Vincent C O Njar
Survival rate for pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) is poor, with about 80% of patients presenting with the metastatic disease. Gemcitabine, the standard chemotherapeutic agent for locally advanced and metastatic PDAC has limited efficacy, attributed to innate/acquired resistance and activation of pro-survival pathways. The Mnk1/2-eIF4E and NF-κB signaling pathways are implicated in PDAC disease progression/metastasis and also associated with gemcitabine-induced resistance in PDAC...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881590/upregulation-of-microrna-125b-by-g-csf-promotes-metastasis-in-colorectal-cancer
#13
Xinghua Zhang, Xiao Ma, Huaying An, Changqing Xu, Wenjo Cao, Wei Yuan, Jie Ma
Although there are reports of miR-125b being dysregulated in colorectal cancer (CRC) and associated with CRC progression, little is known about its intrinsic regulatory mechanisms. Here we detected the expression of miR-125b in CRC tissues, subsequently investigated the effect of miR-125b on the proliferation, apoptosis, cell cycle and metastasis on CRC cells. Our results showed that the expression of miR-125b was significantly decreased in CRC tissues comparing to adjacent tissues. However, with the stimulation of Granulocyte colony-stimulating factor (G-CSF), which was highly expressed in CRC tissues, the expression of miR-125b could be improved...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28880251/studying-electrotaxis-in-microfluidic-devices
#14
REVIEW
Yung-Shin Sun
Collective cell migration is important in various physiological processes such as morphogenesis, cancer metastasis and cell regeneration. Such migration can be induced and guided by different chemical and physical cues. Electrotaxis, referring to the directional migration of adherent cells under stimulus of electric fields, is believed to be highly involved in the wound-healing process. Electrotactic experiments are conventionally conducted in Petri dishes or cover glasses wherein cells are cultured and electric fields are applied...
September 7, 2017: Sensors
https://www.readbyqxmd.com/read/28877752/spen-a-new-player-in-primary-cilia-formation-and-cell-migration-in-breast-cancer
#15
Stéphanie Légaré, Catherine Chabot, Mark Basik
BACKGROUND: The primary cilium is a microtubule-based and nonmotile organelle functioning as a cellular antenna that is involved in the regulation of cell proliferation, differentiation, and migration. In breast cancer cells, the primary cilium is a structure that decreases in incidence with increasing degrees of transformation and may be biologically more important in estrogen receptor (ERα)-negative breast cancer cells. Split ends (SPEN) is an ERα corepressor that we have identified as a tumor suppressor protein in ERα-positive breast cancer cells whose hormone-independent roles in breast cancer have never been explored...
September 6, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28869833/yap-promotes-hepatocellular-carcinoma-metastasis-and-mobilization-via-governing-cofilin-f-actin-lamellipodium-axis-by-regulation-of-jnk-bnip3-serca-camkii-pathways
#16
Chen Shi, Yong Cai, Yongheng Li, Ye Li, Nan Hu, Sai Ma, Shunying Hu, Pingjun Zhu, Weihu Wang, Hao Zhou
Despite the increasingly important role of Hippo-Yap in hepatocellular carcinoma (HCC) development and progression, little insight is available at the time regarding the specifics interaction of Yap and cancer cells migration. Here, we identified the mechanism by which tumor-intrinsic Yap deletion resulted in HCC migratory inhibition. Yap was greatly upregulated in HCC and its expression promoted the cells migration. Functional studies found that knockdown of Yap induced JNK phosphorylation which closely bound to the Bnip3 promoter and contributed to Bnip3 expression...
August 24, 2017: Redox Biology
https://www.readbyqxmd.com/read/28861166/ykl-40-promotes-the-migration-and-invasion-of-prostate-cancer-cells-by-regulating-epithelial-mesenchymal-transition
#17
Hailong Hao, Lei Wang, Huiqing Chen, Liwu Xie, Tao Bai, Hongyu Liu, Dongwen Wang
OBJECTIVE: This study aims to observe the expression of YKL-40 in prostate cancer and whether YKL-40 can affect the migration and invasion of tumor cells by regulating epithelial mesenchymal transition. METHODS: We collected 14 cases of prostate cancer tissues and adjacent tissues in this study. The expression levels of YKL-40 in the tissues were analyzed by western blotting and immunohistochemical methods. The expression of YKL-40 in human prostate cancer cell line DU145 and PC3 was detected by fluorescence quantitative PCR and western blotting methods...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28845296/tumor-cell-senescence-response-produces-aggressive-variants
#18
Leixiang Yang, Jia Fang, Jiandong Chen
Tumors often respond favorably to initial chemotherapy but eventually relapse with drug resistance and increased metastatic potential. Cellular senescence is a major therapeutic outcome of cancer chemotherapy, which leads to tumor stasis or regression through immune clearance of senescent cells. However, senescent tumor cells have been shown to resume proliferation at low frequency. We found that subjecting arrested senescent tumor cells to cytotoxic treatments stimulates the clonogenic proliferation of remaining survivors...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28842850/a-flavonoid-glycoside-compound-from-murraya-paniculata-l-interrupts-metastatic-characteristics-of-a549-cells-by-regulating-stat3-nf-%C3%AE%C2%BAb-cox-2-and-egfr-signaling-pathways
#19
Qing Shi, Zhou Jiang, Jingyi Yang, Yunlong Cheng, Yaqiong Pang, Ning Zheng, Jiahang Chen, Wenge Chen, Lee Jia
Metastasis remains the leading cause of death from lung carcinoma. It is urgent to find safe and efficient pre-metastasis preventive agents for cancer survivors. We isolated a flavonoid glycoside, hexamethoxy flavanone-o-[rhamnopyranosyl-(1 → 4)-rhamnopyranoside (HMFRR), from the traditional Chinese medicine (TCM) Murraya paniculata (L.) that can effectively inhibit the adhesion, migration, and invasion of lung adenocarcinoma A549 cells in vitro. Molecular and cellular studies demonstrated that HMFRR significantly downregulated the expressions of cell adhesion-related and invasion-related molecules such as integrin β1, EGFR, COX-2, MMP-2, and MMP-9 proteins...
August 25, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28829370/mir-30a-5p-inhibits-epithelial-to-mesenchymal-transition-and-upregulates-expression-of-tight-junction-protein-claudin-5-in-human-upper-tract-urothelial-carcinoma-cells
#20
Yueh-Hua Chung, Sung-Chou Li, Ying-Hsien Kao, Hao-Lun Luo, Yuan-Tso Cheng, Pey-Ru Lin, Ming-Hong Tai, Po-Hui Chiang
The involvement of microRNAs (miRNAs) in cancer development and their potential as prognostic biomarkers are becoming increasingly known. However, the signature of miRNAs and their regulatory roles in tumorigenesis of upper tract urothelial carcinoma (UTUC) remain to be elucidated. This study aimed to profile the miRNA expression pattern in UTUC tumor tissues and identify candidate miRNAs with prognostic and/or therapeutic functions. METHODS AND RESULTS: We collected 22 UTUC tissue and adjacent normal tissues samples from patients who underwent nephroureterectomy...
August 22, 2017: International Journal of Molecular Sciences
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