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https://www.readbyqxmd.com/read/29450150/chemical-composition-analysis-and-in-vitro-biological-activities-of-ten-essential-oils-in-human-skin-cells
#1
Xuesheng Han, Cody Beaumont, Nicole Stevens
Research on the biological effects of essential oils on human skin cells is scarce. In the current study, we primarily explored the biological activities of 10 essential oils (nine single and one blend) in a pre-inflamed human dermal fibroblast system that simulated chronic inflammation. We measured levels of proteins critical for inflammation, immune responses, and tissue-remodeling processes. The nine single oils were distilled from Citrus bergamia (bergamot), Coriandrum sativum (cilantro), Pelargonium graveolens (geranium), Helichrysum italicum (helichrysum), Pogostemon cablin (patchouli), Citrus aurantium (petitgrain), Santalum album (sandalwood), Nardostachys jatamansi (spikenard), and Cananga odorata (ylang ylang)...
December 2017: Biochimie Open
https://www.readbyqxmd.com/read/29351747/combination-of-pelargonium-sidoides-and-coptis-chinensis-root-inhibits-nuclear-factor-kappa-b-mediated-inflammatory-response-in-vitro-and-in-vivo
#2
Sang Mi Park, Byung-Gu Min, Ji Yun Jung, Kyung Hwan Jegal, Chul Won Lee, Kwang Youn Kim, Young Woo Kim, Youn-Woong Choi, Il Je Cho, Sae Kwang Ku, Sang Chan Kim
BACKGROUND: Pelargonium sidoides (PS) and Coptis chinensis root (CR) have traditionally been used to treat various diseases, including respiratory and gastrointestinal infections, dysmenorrhea, and hepatic disorders. The present study was conducted to evaluate the anti-inflammatory effects of a combination of PS and CR in vitro and in vivo. METHODS: The in vitro effects of PS + CR on the induction of inflammation-related proteins were evaluated in lipopolysaccharide (LPS)-stimulated RAW 264...
January 19, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29318991/in-vitro-investigation-of-the-pediculicidal-activities-of-the-volatile-oil-components-of-some-medical-plants-raised-in-turkey
#3
M Emin Limoncu, Cüneyt Balcıoğlu, Tuğba Oyur, Gizem Zeybek, Ulvi Zeybek
OBJECTIVE: The human head louse Pediculus capitis has recently acquired resistance to commercially available insecticides, which has expanded the search concerning the pediculicidal activities of some herbal products. The present study aimed to assess the in vitro pediculicidal activities of volatile oils extracted from 10 medical plants raised in Turkey: Rosa damascena (red provins rose), Pelargonium graveolens (geranium), Lavandula angustifolia (lavender), Salvia triloba (salvia), Rosmarinus officinalis (rosemary; two different chemotypes), Citrus bergamia (citrus tree), Cymbopogon nardus (citronella), Citrus limonum (lemon), and Cymbopogon flexuosus (lemongrass)...
December 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29231073/pelargonium-sidoides-preparation-eps-7630-in-copd-health-related-quality-of-life-and-other-patient-reported-outcomes-in-adults-receiving-add-on-therapy
#4
Heinrich Matthys, Petra Funk
OBJECTIVE: Patient-reported outcomes (PRO) such as health-related quality of life (HRQL) belong to the most important criteria for the evaluation of medical therapies in clinical trials or practice-based benefit assessments. We therefore revisited results of an earlier published clinical trial investigating the effects of the herbal drug preparation from the roots of Pelargonium sidoides EPs 7630, administered as add-on therapy in patients suffering from chronic obstructive pulmonary disease (COPD), with respect to HRQL and other PRO...
December 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29183576/geranium-intoxication-induces-detoxification-enzymes-in-the-japanese-beetle-popillia-japonica-newman
#5
Adekunle W Adesanya, David W Held, Nannan Liu
Popillia japonica is a generalist herbivore that feeds on >300 host plant species in at least 72 plant families. It is unknown why P. japonica, despite possessing active detoxification enzymes in its gut, is paralyzed when feeding on the petals of one of its preferred host plant, Pelargonium×hortorum, or on artificial diet containing quisqualic acid (QA), the active compound in zonal geranium. We hypothesized that Pelargonium×hortorum or QA do not induce activity of the cytochrome P450, glutathione S transferase (GST), and carboxylesterase (CoE) detoxification enzymes in P...
November 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29149072/different-inhibitory-potencies-of-oseltamivir-carboxylate-zanamivir-and-several-tannins-on-bacterial-and-viral-neuraminidases-as-assessed-in-a-cell-free-fluorescence-based-enzyme-inhibition-assay
#6
Stefanie Quosdorf, Anja Schuetz, Herbert Kolodziej
Neuraminidaseis a key enzyme in the life cycle of influenza viruses and is present in some bacterial pathogens. We here assess the inhibitory potency of plant tannins versus clinically used inhibitors on both a viral and a bacterial model neuraminidase by applying the 2'-(4-methylumbelliferyl)-α-d-N-acetylneuraminic acid (MUNANA)-based activity assay. A range of flavan-3-ols, ellagitannins and chemically defined proanthocyanidin fractions was evaluated in comparison to oseltamivir carboxylate and zanamivir for their inhibitory activities against viral influenza A (H1N1) and bacterial Vibrio cholerae neuraminidase (VCNA)...
November 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29119837/eps-7630-is-effective-and-safe-in-children-under-6-years-with-acute-respiratory-tract-infections-clinical-studies-revisited
#7
Wolfgang Kamin, Petra Funk, Georg Seifert, Andrea Zimmermann, Walter Lehmacher
Objective - Pelargonium sidoides preparation EPs 7630 has been proven safe and effective in acute respiratory tract infections (aRTIs), but data for young children have not been presented separately. We reviewed clinical studies and present an overview of known and newly analyzed data from children <6 years. Methods - We searched MEDLINE and EMBASE for interventional and non-interventional studies which investigated the effects of EPs 7630 in aRTIs and included children <6 years of age. Subgroup analyses for this age range were performed for symptom scales, global efficacy or effectiveness assessments, and safety outcomes...
November 9, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29099738/anti-inflammatory-effect-of-malva-sylvestris-sida-cordifolia-and-pelargonium-graveolens-is-related-to-inhibition-of-prostanoid-production
#8
Cleverson Antonio Ferreira Martins, Michel Leandro Campos, Ana Carolina Irioda, Dile Pontarolo Stremel, Angela Cristina Leal Badaró Trindade, Roberto Pontarolo
The ability of plant extracts and preparations to reduce inflammation has been proven by different means in experimental models. Since inflammation enhances the release of specific mediators, inhibition of their production can be used to investigate the anti-inflammatory effect of plants widely used in folk medicine for this purpose. The study was performed for leaves and flowers of Malva sylvestris, and leaves of Sida cordifolia and Pelargonium graveolens. These are three plant species known in Brazil as Malva...
November 3, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29093729/an-update-on-the-intracellular-and-intercellular-trafficking-of-carmoviruses
#9
REVIEW
José A Navarro, Vicente Pallás
Despite harboring the smallest genomes among plant RNA viruses, carmoviruses have emerged as an ideal model system for studying essential steps of the viral cycle including intracellular and intercellular trafficking. Two small movement proteins, formerly known as double gene block proteins (DGBp1 and DGBp2), have been involved in the movement throughout the plant of some members of carmovirus genera. DGBp1 RNA-binding capability was indispensable for cell-to-cell movement indicating that viral genomes must interact with DGBp1 to be transported...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29055287/efficacy-and-tolerability-of-high-dose-pelargonium-extract-in-patients-with-the-common-cold
#10
David S Riley, Viktor G Lizogub, Andrea Zimmermann, Petra Funk, Walter Lehmacher
Context • The common cold (CC) is usually caused by a viral infection. Antibiotics are often prescribed unnecessarily for it, although no evidence exists for any benefit in the CC. Effective alternatives are needed. Objective • The study intended to evaluate the efficacy of 7630, a proprietary extract of Pelargonium sidoides, the active ingredient in umckaloabo, compared with a placebo for the treatment of the CC. Design • This was a prospective, double-blind, parallel-group, placebo-controlled, phase 3 clinical trial (RCT), with an adaptive group-sequential design with 2 parts, both of which were 2-arm trials...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28961907/the-relationship-between-nectaries-and-floral-architecture-a-case-study-in-geraniaceae-and-hypseocharitaceae
#11
Julius Jeiter, Hartmut H Hilger, Erik F Smets, Maximilian Weigend
Background and Aims: Flowers of Geraniaceae and Hypseocharitaceae are generally considered as morphologically simple. However, previous studies indicated complex diversity in floral architecture including tendencies towards synorganization. Most of the species have nectar-rewarding flowers which makes the nectaries a key component of floral organization and architecture. Here, the development of the floral nectaries is studied and placed into the context of floral architecture. Methods: Seven species from Geraniaceae and one from Hypseocharitaceae were investigated using scanning electron microscopy and light microscopy...
November 10, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28924942/exploring-the-anti-proliferative-activity-of-pelargonium-sidoides-dc-with-in-silico-target-identification-and-network-pharmacology
#12
A S P Pereira, M J Bester, Z Apostolides
Pelargonium sidoides DC (Geraniaceae) is a medicinal plant indigenous to Southern Africa that has been widely evaluated for its use in the treatment of upper respiratory tract infections. In recent studies, the anti-proliferative potential of P. sidoides was shown, and several phenolic compounds were identified as the bioactive compounds. Little, however, is known regarding their anti-proliferative protein targets. In this study, the anti-proliferative mechanisms of P. sidoides through in silico target identification and network pharmacology methodologies were evaluated...
November 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28888889/biofabrication-of-polyphenols-coated-nano-palladium-and-its-in-vitro-cytotoxicity-against-human-leukemia-cell-lines-k562
#13
Yingchun Li, Huihan Wang, Rong Zhang, Guojun Zhang, Ying Yang, Zhuogang Liu
The biofabrication of palladium nanoparticles (PdNPs) using aqueous leaf extract of Pelargonium graveolens is reported herein. The polyphenols present in the Pelargonium graveolens extract are mainly responsible for reduction and subsequent stabilization of formed PdNPs. UV-Visible spectroscopy (UV-Vis) absorption and reaction color change from yellow to brown indicated the formation of PdNPs. The as synthesized PdNPs were studied by using characterization techniques such as Fourier transform infrared spectroscopy (FTIR), Transmission electron microscopy (TEM), Energy dispersive spectroscopy (EDS), Zeta potential measurements and Selected area electron diffraction (SAED)...
July 25, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28876249/growing-substrates-for-aromatic-plant-species-in-green-roofs-and-water-runoff-quality-pilot-experiments-in-a-mediterranean-climate
#14
Cristina M Monteiro, Cristina S C Calheiros, Paulo Palha, Paula M L Castro
Green roof technology has evolved in recent years as a potential solution to promote vegetation in urban areas. Green roof studies for Mediterranean climates, where extended drought periods in summer contrast with cold and rainy periods in winter, are still scarce. The present research study assesses the use of substrates with different compositions for the growth of six aromatic plant species - Lavandula dentata, Pelargonium odoratissimum, Helichrysum italicum, Satureja montana, Thymus caespititius and T. pseudolanuginosus, during a 2-year period, and the monitoring of water runoff quality...
September 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28766033/antifungal-mechanism-of-the-combination-of-cinnamomum-verum-and-pelargonium-graveolens-essential-oils-with-fluconazole-against-pathogenic-candida-strains
#15
Rym Essid, Majdi Hammami, Dorra Gharbi, Ines Karkouch, Thouraya Ben Hamouda, Salem Elkahoui, Ferid Limam, Olfa Tabbene
The present study aimed to investigate the anti-Candida activity of ten essential oils (EOs) and to evaluate their potential synergism with conventional drugs. The effect on secreted aspartic protease (SAP) activity and the mechanism of action were also explored. The antifungal properties of essential oils were investigated using standard micro-broth dilution assay. Only Cinnamomum verum, Thymus capitatus, Syzygium aromaticum, and Pelargonium graveolens exhibited a broad spectrum of activity against a variety of pathogenic Candida strains...
August 1, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28743644/species-trees-from-consensus-single-nucleotide-polymorphism-snp-data-testing-phylogenetic-approaches-with-simulated-and-empirical-data
#16
Alexander N Schmidt-Lebuhn, Nicola C Aitken, Aaron Chuah
Datasets of hundreds or thousands of SNPs (Single Nucleotide Polymorphisms) from multiple individuals per species are increasingly used to study population structure, species delimitation and shallow phylogenetics. The principal software tool to infer species or population trees from SNP data is currently the BEAST template SNAPP which uses a Bayesian coalescent analysis. However, it is computationally extremely demanding and tolerates only small amounts of missing data. We used simulated and empirical SNPs from plants (Australian Craspedia, Asteraceae, and Pelargonium, Geraniaceae) to compare species trees produced (1) by SNAPP, (2) using SVD quartets, and (3) using Bayesian and parsimony analysis with several different approaches to summarising data from multiple samples into one set of traits per species...
November 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28735475/antioxidant-and-antibacterial-activities-of-pelargonium-asperum-and-ormenis-mixta-essential-oils-and-their-synergistic-antibacterial-effect
#17
Wessal Ouedrhiri, Mounyr Balouiri, Samira Bouhdid, El Houssaine Harki, Sandrine Moja, Hassane Greche
In this work, the chemical composition, the antioxidant, and the antibacterial activities of two Moroccan essential oils less studied, extracted from Pelargonium asperum and Ormenis mixta, were investigated. According to the gas chromatography coupled to mass spectrometry analysis, citronellol (25.07%), citronellyl ester (10.52%), geraniol (10.46%), and buthyl anthranilate (5.93%) were found to be the major components of P. asperum, while O. mixta was mainly composed of D-germacrene (11.46%), 1,8-cineole (10...
July 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28629407/antibacterial-activity-of-crude-extracts-of-some-south-african-medicinal-plants-against-multidrug-resistant-etiological-agents-of-diarrhoea
#18
Mary A Bisi-Johnson, Chikwelu L Obi, Babatunde B Samuel, Jacobus N Eloff, Anthony I Okoh
BACKGROUND: This study evaluated the antibacterial activity of some plants used in folklore medicine to treat diarrhoea in the Eastern Cape Province, South Africa. METHODS: The acetone extracts of Acacia mearnsii De Wild., Aloe arborescens Mill., A. striata Haw., Cyathula uncinulata (Schrad.) Schinz, Eucomis autumnalis (Mill.) Chitt., E. comosa (Houtt.) Wehrh., Hermbstaedtia odorata (Burch. ex Moq.) T.Cooke, Hydnora africana Thunb, Hypoxis latifolia Wight, Pelargonium sidoides DC, Psidium guajava L and Schizocarphus nervosus (Burch...
June 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28610802/herbal-medicine-in-children-with-respiratory-tract-infection-systematic-review-and-meta-analysis
#19
REVIEW
Dennis Anheyer, Holger Cramer, Romy Lauche, Felix Joyonto Saha, Gustav Dobos
BACKGROUND: Herbal medicines are particularly regarded as an alternative or complement to conventional pharmaceuticals in the treatment and prevention of respiratory tract infections (RTIs). Therefore, the purpose of this review was to identify evidence for herbal therapy in the treatment of RTIs concerning effectiveness and safety. METHODS: Medline/PubMed, Scopus, and the Cochrane Library were searched through February 12, 2015. Randomized controlled trials that compared herbal therapy with no treatment, placebo, or any pharmaceutical medication in children and adolescents (age 0 to 18 years) with RTI were eligible...
June 10, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28448560/activity-of-xyloglucan-endotransglucosylases-hydrolases-suggests-a-role-during-host-invasion-by-the-parasitic-plant-cuscuta-reflexa
#20
Stian Olsen, Kirsten Krause
The parasitic vines of the genus Cuscuta form haustoria that grow into other plants and connect with their vascular system, thus allowing the parasite to feed on its host. A major obstacle that meets the infection organ as it penetrates the host tissue is the rigid plant cell wall. In the present study, we examined the activity of xyloglucan endotransglucosylases/hydrolases (XTHs) during the host-invasive growth of the haustorium. The level of xyloglucan endotransglucosylation (XET) activity was found to peak at the penetrating stage of Cuscuta reflexa on its host Pelargonium zonale...
2017: PloS One
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