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Carcinoid heart disease

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https://www.readbyqxmd.com/read/28205198/a-51-year-old-patient-with-carcinoid-heart-disease-and-severe-tricuspid-regurgitation
#1
Elżbieta Florczak, Mariola Pęczkowska, Marek Konka, Jacek Różański, Agnieszka Kolasińska-Ćwikła
No abstract text is available yet for this article.
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28163047/curious-case-of-wheezing-carcinoid-heart-disease
#2
Dhaval Desai, M Fuad Jan, Nataly Stenzel, Paul Werner, A Jamil Tajik
No abstract text is available yet for this article.
February 2, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28069686/inoperable-primary-ovarian-carcinoid-led-to-the-progression-of-carcinoid-heart-disease-from-right-sided-to-both-sided-involvement
#3
Tomonori Tadokoro, Shunsuke Katsuki, Koji Ito, Ken Onitsuka, Atsuhiro Nakashima, Takakazu Sasaguri, Kenji Miyata, Hideo Yamamoto, Masahiro Mohri
No abstract text is available yet for this article.
January 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28029208/pulmonary-and-tricuspid-valvuloplasty-in-carcinoid-heart-disease
#4
Ashkan Karimi, Negiin Pourafshar, James C Fudge
A 26-year-old female with carcinoid heart disease consisting of severe pulmonary and tricuspid valve stenosis was admitted with line associated sepsis. She recovered from sepsis with antibiotics and aggressive fluid resuscitation but became grossly volume overloaded with evidence of tense ascites and lower extremity edema. She developed worsening renal and hepatic function due to congestive nephropathy and hepatopathy, which did not respond to intravenous diuretics, and she was deemed too sick for surgical pulmonary and tricuspid valve replacement...
December 28, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27989047/results-of-contemporary-valve-surgery-in-patients-with-carcinoid-heart-disease
#5
Thomas Kuntze, Tamer Owais, Maria-Anna Secknus, Daniel Kaemmerer, Richard Baum, Evaldas Girdauskas
BACKGROUND: Carcinoid tumor is a slow-growing type of neuroendocrine tumor, originating from enterochromaffin cells and secreting mainly serotonin. The diagnosis is based on clinical symptoms, hormone blood levels, radiological and nuclear imaging, and histological confirmation. However, most patients have metastases at the time of diagnosis because the clinical signs often remain unnoticed or are attributed to other abdominal conditions. In up to 50% of patients the endocardium is affected due to a hormonally active tumor profile...
May 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27989046/valve-replacement-in-patients-with-carcinoid-heart-disease-choosing-the-right-valve-at-the-right-time
#6
Amit Korach, Simona Grozinsky-Glasberg, Joseph Atlan, Abeer Dabah, Karine Atlan, Ehud Rudis, Amir Elami, David J Gross, Michael J Reardon, Oz M Shapira
BACKGROUND: The prosthetic valve of choice in patients with carcinoid valve disease (CVD) remains controversial due to the limited life expectancy of patients with advanced-stage neuroendocrine tumors (NETs) on the one hand, and concerns regarding structural valve deterioration (SVD) on the other hand. METHODS: The records of 17 patients (11 females, seven males; mean age 65 ± 11 years; undergoing 18 operations) with primarily right heart failure due to CVD were reviewed...
May 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27982350/valvular-disorders-in-carcinoid-heart-disease
#7
Shi-Min Yuan
Carcinoid heart disease is a rare but important cause of intrinsic right heart valve disorders leading to right heart failure. Occasionally, left-sided heart valves may also be involved. The characteristic cardiac pathological findings of carcinoid heart disease are endocardial thickening as a result of fibrous deposits on the endocardium. Echocardiographic examination and right heart catheterization are very useful for the diagnosis of the lesion. If more cardiac valves are affected, multiple valve replacement should be considered...
September 2016: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27976548/percutaneous-balloon-valvuloplasty-in-carcinoid-pulmonary-valve-stenosis
#8
Vibeke Guldbrand Rasmussen, Helle Lynge Kanstrup, Jens Erik Nielsen-Kudsk
More than half of patients with carcinoid syndrome develop carcinoid valve disease. Both the tricuspid and pulmonary valve are often involved. Symptoms of carcinoid syndrome with flushing, diarrhea, and bronchospasm often precedes cardiac symptoms. We report a case of carcinoid initially presenting with rapid development of right heart failure due to severe pulmonary valve stenosis. In untreated carcinoid, there is a risk of carcinoid crisis with anesthesia and surgery. In local anesthesia, we performed a sub-acute balloon pulmonary valvuloplasty...
December 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27861745/clinical-signs-of-fibrosis-in-small-intestinal-neuroendocrine-tumours
#9
K Daskalakis, A Karakatsanis, P Stålberg, O Norlén, P Hellman
BACKGROUND: In patients with small intestinal neuroendocrine tumours (SI-NETs), serotonin and other cytokines released from tumour cells may induce fibrosis, leading to carcinoid heart disease and abdominal fibrotic reactions. The aim of this study was to assess the prevalence, clinical complications and management of this reaction in the abdomen. METHODS: This was a retrospective cohort study of patients with SI-NETs diagnosed between 1985 and 2015. Clinical data, outcomes, radiological findings, and surgical and radiological interventions were reviewed...
January 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/27832643/cardiac-surgery-for-carcinoid-heart-disease-a-weapon-not-to-be-misused
#10
Maria Bonou, Chris J Kapelios, Gregory Kaltsas, Konstantinos Perreas, Konstantinos Toutouzas, John Barbetseas
Carcinoid heart disease (CHD) complicates approximately 25% of patients with a carcinoid tumor and carcinoid syndrome and leads to heart valve degeneration with mixed-stenotic and regurgitation pathology and consequent heart failure (HF) leading to significant morbidity and mortality. Cardiac surgery in symptomatic, severe CHD leads to significantly better functional capacity and prolonged survival when compared to medical treatment alone. Recent studies have shown improvement in postoperative outcomes of patients undergoing surgery for CHD over the last decades...
November 11, 2016: Cardiology
https://www.readbyqxmd.com/read/27817224/telotristat-ethyl-a-new-option-for-the-management-of-carcinoid-syndrome
#11
REVIEW
Angela Lamarca, Jorge Barriuso, Mairéad G McNamara, Richard A Hubner, Juan W Valle
Many patients with neuroendocrine tumour-related carcinoid syndrome treated with somatostatin analogues (SSA) won't achieve adequate symptom relief with the SSA alone; new treatment options are required. Telotristat ethyl is a tryptophan hydroxylase inhibitor, developed for the treatment of carcinoid syndrome. Areas covered: This review summarises the evidence supporting the role of telotristat ethyl in the management of carcinoid syndrome. Rationale, pharmacodynamics, pharmacokinetics, metabolism, clinical experience, efficacy and toxicity profiles are covered...
December 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27811856/predictive-factors-of-antiproliferative-activity-of-octreotide-lar-as-first-line-therapy-for-advanced-neuroendocrine-tumours
#12
Faidon-Marios Laskaratos, Martin Walker, Keval Naik, Emmanouil Maragkoudakis, Nikolaos Oikonomopoulos, Lee Grant, Tim Meyer, Martyn Caplin, Christos Toumpanakis
BACKGROUND: The antiproliferative activity of octreotide LAR in neuroendocrine tumours (NETs) has been demonstrated by small retrospective studies and confirmed by a prospective phase III trial (PROMID). However, there are limited data about the duration and predictors of response. The aim of our retrospective study was to determine the time to radiological progression (TTRP) of disease and the factors that were associated with better response. METHODS: A total of 254 treatment naïve patients with advanced NETs and positive somatostatin receptor scintigraphy were included...
November 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27753110/noninvasive-evaluation-of-right-hemodynamics-in-carcinoid-heart-disease-a-case-report
#13
Marianna Nardozza, Donato Mele, Roberto Ferrari
We report the case of a 67-year-old woman with a carcinoid tumor of midgut origin who developed carcinoid heart disease and died because of bowel perforation. Echocardiography allowed the diagnosis, recognizing the typical abnormalities of tricuspid and pulmonary valve leaflets. The sonographic examination also evidenced peculiar alterations of the right heart hemodynamics: end-diastolic reversal of flow at the level of the pulmonary valve, reduced respiratory excursion without enlargement of the inferior vena cava, and biphasic hepatic venous flow without respiratory variation...
October 18, 2016: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/27687702/incremental-value-of-live-real-time-three-dimensional-transthoracic-echocardiography-over-the-two-dimensional-technique-in-assessing-carcinoid-heart-disease-involving-the-aortic-valve
#14
Bulur Serkan, Ming C Hsiung, Navin C Nanda, Shalaka Hardas, Ahmed Mohamed, Ahmed ElKaryoni, Swetha Srialluri, Kirolos Barssoum, Mahmoud Elsayed, Jeng Wei, Wei-Hsian Yin
We present a case of an adult with metastatic carcinoid heart disease, in whom live/real time three-dimensional transthoracic echocardiography provided incremental value over two-dimensional transthoracic echocardiography in assessing involvement of the aortic valve.
November 2016: Echocardiography
https://www.readbyqxmd.com/read/27623329/-ovarian-carcinoid-tumor-responsible-of-permanent-facial-erythrosis-and-flushings-during-sexual-intercourse
#15
B Talvande, A Dorange, M Lecouflet, M Le Nezet, B Kianifard, H Maillard, M Duquenne
INTRODUCTION: Ovarian neuroendocrine tumors are extremely rare. In the ovary, the term of neuroendocrine tumor is usually related to carcinoid tumors although it may be sometimes applied to neuroendocrine carcinomas of non-small cells or small cells cancers usually occurring in the lungs. These carcinoid tumors may develop de novo or from other tumors including teratomas. CASE REPORT: We report a patient who presented with an ovarian carcinoid tumor developed, near or from a dermoid cyst, which was original by its mode of discovery in the dermatology department...
November 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/27594907/complications-from-carcinoid-syndrome-review-of-the-current-evidence
#16
REVIEW
José Mauricio Mota, Luana Guimarães Sousa, Rachel P Riechelmann
Patients with well-differentiated neuroendocrine tumours may develop carcinoid syndrome (CS), which is characterised by flushing, abdominal cramps, diarrhoea, and bronchospasms. In this scenario, long-term secretion of vasoactive substances-serotonin, tachynins, and others, may induce fibrogenic responses in local or distant tissues, leading to complications such as carcinoid heart disease (CHD), mesenteric and/or retroperitoneal fibrosis. Rare cases of lung/pleural fibrosis and scleroderma have also been described...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27547148/transcatheter-pulmonary-valve-replacement-in-a-carcinoid-heart
#17
Pranav Loyalka, Michael Schechter, Angelo Nascimbene, Ajay Sundara Raman, Cezar A Ilieascu, Igor D Gregoric, Biswajit Kar
Carcinoid heart disease presents as right-sided heart failure attributable to the dysfunction of the tricuspid and pulmonary valves. Although surgical valve replacement is the mainstay of treatment when patients become symptomatic, it is associated with substantial perioperative mortality rates. We present a case of severe pulmonary valve stenosis secondary to carcinoid heart disease, treated successfully with percutaneous valve replacement. A 67-year-old man with severe pulmonary valve stenosis was referred to our center for pulmonary valve replacement...
August 2016: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/27422971/congestive-kidney-failure-in-cardiac-surgery-the-relationship-between-central-venous-pressure-and-acute-kidney-injury
#18
Ivancarmine Gambardella, Mario Gaudino, Claudio Ronco, Christopher Lau, Natalia Ivascu, Leonard N Girardi
Acute kidney injury (AKI) in cardiac surgery has traditionally been linked to reduced arterial perfusion. There is ongoing evidence that central venous pressure (CVP) has a pivotal role in precipitating acute renal dysfunction in cardiac medical and surgical settings. We can regard this AKI driven by systemic venous hypertension as 'kidney congestive failure'. In the cardiac surgery population as a whole, when the CVP value reaches the threshold of 14 mmHg in postoperative period, the risk of AKI increases 2-fold with an odds ratio (OR) of 1...
November 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27402167/primary-ovarian-carcinoid-a-report-of-two-cases-and-a-decade-registry
#19
Islam H Metwally, Amr F Elalfy, Shadi Awny, Islam A Elzahaby, Reham M Abdelghani
OBJECTIVES: This study aims at reporting 2 cases of primary ovarian carcinoid tumor, and providing an adequate registry of such cases and how they were managed. METHODS: 2 female patients with primary ovarian carcinoid were diagnosed and treated in our center. Discussion of their presentation, pathology and treatment is entitled. Also a thorough search of all published registries and case reports of ovarian carcinoid was done with analysis of reported data. RESULTS: 164 cases of primary ovarian carcinoid tumor were detected since 2005 with the predominance of the insular variant...
December 2016: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/27174867/acute-pergolide-exposure-stiffens-engineered-valve-interstitial-cell-tissues-and-reduces-contractility-in-vitro
#20
Andrew K Capulli, Luke A MacQueen, Blakely B O'Connor, Stephanie Dauth, Kevin Kit Parker
Medications based on ergoline-derived dopamine and serotonin agonists are associated with off-target toxicities that include valvular heart disease (VHD). Reports of drug-induced VHD resulted in the withdrawal of appetite suppressants containing fenfluramine and phentermine from the US market in 1997 and pergolide, a Parkinson's disease medication, in 2007. Recent evidence suggests that serotonin receptor activity affected by these medications modulates cardiac valve interstitial cell activation and subsequent valvular remodeling, which can lead to cardiac valve fibrosis and dysfunction similar to that seen in carcinoid heart disease...
July 2016: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
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