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https://www.readbyqxmd.com/read/28289658/expressions-and-clinical-significances-of-angiopoietin-1-angiopoietin-2-and-tie-2-receptor-in-patients-with-colorectal-cancer
#1
Sunghoon Hong, Hae Il Jung, Tae Sung Ahn, Han-Jo Kim, Kyu-Taek Lee, Moo-Jun Baek, Sang-Byung Bae
PURPOSE: Angiopoietin-1 (Ang-1) plays a crucial role in vascular and hematopoietic development, mainly through its cognate receptor, Tie-2. Increased levels of Ang-2 have been shown to be correlated with abnormal tumor angiogenesis in several malignancies. Hence, we estimated the increased expression of Ang-2 relative to Ang-1 in patients with colorectal cancer and correlated our finding with prognosis in order to investigate the relationships between the expressions of Ang-1/Ang-2/Tie-2 receptor and the clinical parameters or overall survival of such patients...
February 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/28279663/mir-146a-mediates-inflammatory-changes-and-fibrosis-in-the-heart-in-diabetes
#2
Biao Feng, Shali Chen, Andrew Devon Gordon, Subrata Chakrabarti
Hyperglycemia induced endothelial injury is a key pathogenetic factor in diabetic cardiomyopathy. In diabetes, changes in pro-inflammatory cytokines are a key mechanism leading to cardiac fibrosis. We have previously demonstrated alteration of miR-146a in chronic diabetic complications. Here, we investigated the role of endothelial miR-146a in mediating inflammation and fibrosis in diabetic cardiomyopathy. To examine the effects of miR-146a on the inflammatory mediators, an endothelial specific miR-146a overexpressing transgenic mice (TG) using tie-2 promoter, was generated...
March 6, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28263822/low-testosterone-levels-result-in-decreased-periurethral-vascularity-via-an-androgen-receptor-mediated-process-pilot-study-in-urethral-stricture-tissue
#3
Matthias D Hofer, Payal Kapur, Billy H Cordon, Farrah Hamoun, David Russell, Jeremy M Scott, Claus G Roehrborn, Allen F Morey
OBJECTIVE: To compare expression of androgen receptor (AR) and angiopoietin 1 receptor TIE-2 and vessel density of urethral stricture tissue among eugonadal and hypogonadal men to identify a pathophysiological basis for our observations that low testosterone is associated with urethral atrophy. METHODS: Among 1200 men having urethroplasty at our institution, we retrospectively identified 11 patients with testosterone levels drawn within 2 years of surgery. Low testosterone was defined as <280 ng/dL and detected in 5 of 11 (45...
March 2, 2017: Urology
https://www.readbyqxmd.com/read/28261893/astrocyte-activation-and-capillary-remodeling-in-a-modified-bilateral-common-carotid-artery-occlusion-mice
#4
Jiangman Song, Di Nan, Qihua He, Lu Yang, Huailian Guo
OBJECTIVE: The cerebral ischemia leads to brain dysfunction with neuron degeneration and responses from astrocytes and vessels. The aim of this study was to study the changes of astrocyte and microvessel in a modified bilateral common carotid artery occlusion (modified BCCAO) mice. METHODS: Adult transgenic Tie-2 GFP mice were subject to modified BCCAO operation and cranial window implantation. Cerebral blood flow and neurological injury was examined after ischemia...
March 6, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28238760/vascular-and-cellular-changes-accompany-altered-expression-of-angiopoietins-in-placenta-of-non-complicated-art-pregnancies
#5
Ahmed A M Abdel-Hamid, Alaa El-Din L Firgany, Yaser Mesbah, Mona Fm Soliman
BACKGROUND: ART is steadily performed for infertility cases and most of the previous researches have focused on complicated pregnancies. Nonetheless, few ones have concerned with placenta of ART in non-complicated pregnancies. OBJECTIVES: To investigate the expression of angiopoietins (ANG) and their receptor, TIE-2, in placenta of full-term non-complicated pregnancies having ART (n=28) versus those with spontaneous conception (n=28) together with the histological as well as morphometric analysis...
February 24, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28219791/bone-marrow-mesenchymal-stem-cells-conditioned-medium-enhances-vascular-remodeling-after-stroke-in-type-2-diabetic-rats
#6
Jie Xiang, Jinxia Hu, Tong Shen, Bin Liu, Fang Hua, Kun Zan, Jie Zu, Guiyun Cui, Xinchun Ye
Our previous studies have found that stem cells conditioned medium (CM) facilitated functional recovery after stroke in non-diabetics. However, whether bone marrow stromal cells conditioned medium (BMSCs-CM) treatment after stroke in type 2 diabetic (T2DM) rats improve functional outcomes remains unclear. T2DM rats were induced and subjected to stroke then treated with or without BMSCs-CM. Functional outcomes and blood-brain barrier (BBB) leakage were performed, the expression of Angiopoietin (Ang) 1 and tyrosine kinase (Tie) 2 were also assessed...
February 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28203097/cerebral-malaria-insight-into-pathogenesis-complications-and-molecular-biomarkers
#7
Farah Hafiz Yusuf, Muhammad Yusuf Hafiz, Maria Shoaib, Syed Ahsanuddin Ahmed
Cerebral malaria is a medical emergency. All patients with Plasmodium falciparum malaria with neurologic manifestations of any degree should be urgently treated as cases of cerebral malaria. Pathogenesis of cerebral malaria is due to damaged vascular endothelium by parasite sequestration, inflammatory cytokine production and vascular leakage, which result in brain hypoxia, as indicated by increased lactate and alanine concentrations. The levels of the biomarkers' histidine-rich protein II, angiopoietin-Tie-2 system and plasma osteoprotegrin serve as diagnostic and prognostic markers...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28202293/therapeutic-hypothermia-attenuates-brain-edema-in-a-pig-model-of-cardiac-arrest-possible-role-of-the-angiopoietin-tie-2-system
#8
Jiebin Li, ChunSheng Li, Wei Yuan, JunYuan Wu, Jie Li, ZhenHua Li, YongZhen Zhao
OBJECTIVE: This study aimed to clarify whether therapeutic hypothermia protects against cerebral edema following cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) in a porcine model via regulating the angiopoietin-Tie-2 ligand-receptor system. METHODS: Male pigs were randomized into the therapeutic hypothermia group, the normothermia group or the sham control group. CA was induced in pigs by untreated ventricular fibrillation for 8min. Brain edema was determined by measuring the cerebral cortical water content at 24h after the return of spontaneous circulation (ROSC)...
February 6, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28185955/endothelial-nox4-based-nadph-oxidase-regulates-atherosclerosis-via-soluble-epoxide-hydrolase
#9
Pingping Hu, Xiaojuan Wu, Alok R Khandelwal, Weimin Yu, Zaicheng Xu, Lili Chen, Jian Yang, Robert M Weisbrod, Kin Sing Stephen Lee, Francesca Seta, Bruce D Hammock, Richard A Cohen, Chunyu Zeng, Xiaoyong Tong
Nox4-based NADPH oxidase is a major reactive oxygen species-generating enzyme in the vasculature, but its role in atherosclerosis remains controversial. OBJECTIVE: Our goal was to investigate the mechanisms of endothelial Nox4 in regulating atherosclerosis. APPROACH AND RESULTS: Atherosclerosis-prone conditions (disturbed blood flow, type I diabetes, and Western diet) downregulated endothelial Nox4 mRNA in arteries. To address whether the downregulated endothelial Nox4 was directly involved in the development of atherosclerosis, we generated mice carrying a human Nox4 P437H dominant negative mutation (Nox4DN), driven by the endothelial specific promoter Tie-2, on atherosclerosis-prone genetic background (ApoE deficient mice) to mimic the effect of decreased endothelial Nox4...
February 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28157471/angiopoietins-as-biomarkers-of-disease-severity-and-bacterial-burden-in-pulmonary-tuberculosis
#10
N P Kumar, B Velayutham, D Nair, S Babu
BACKGROUND: Circulating angiogenic factors of the vascular endothelial growth factor family are important biomarkers of disease severity in pulmonary tuberculosis (PTB). However, the role of angiopoietins, which are also involved in angiogenesis, in PTB is not known. OBJECTIVE AND DESIGN: To examine the association of circulating angiopoietins with TB disease or latent tuberculous infection (LTBI), we examined the systemic levels of angiopoietin (Ang) 1, Ang 2 and Tie-2 receptor in individuals with PTB (n = 44), LTBI (n = 44) or no tuberculous infection (NTBI) (n = 44)...
January 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28068599/discovery-of-novel-anti-angiogenesis-agents-part-6-multi-targeted-rtk-inhibitors
#11
Lin Zhang, Yuanyuan Shan, Chuansheng Li, Ying Sun, Ping Su, Jinfeng Wang, Lisha Li, Xiaoyan Pan, Jie Zhang
Angiogenesis is modulated by a multitude of pro-angiogenic factors including VEGFR-2, Tie-2, and EphB4. Moreover, their crosstalk also had been well elaborated. We have identified several diarylurea-based VEGFR-2 inhibitors as potential anti-angiogenesis agents. As a continuation to our previous research, two series of diaryl malonamide and diaryl thiourea derivatives have been developed as multiplex VEGFR-2/Tie-2/EphB4 inhibitors. Interestingly, the biological evaluation indicated that several compounds bearing trifluoromethyl or trifluoromethoxyl exhibited promising multiplex inhibition against angiogenesis-related VEGFR-2, Tie-2, and EphB4...
February 15, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28041961/expression-of-angiopoietins-in-central-nervous-system-hemangioblastomas-is-associated-with-cyst-formation
#12
Xiang Li, Wenke Liu, Jianping Liu, Weiya Wang, Si Zhang, Jian Chen, Xuhui Hui
PURPOSE: This study aimed to determine the expression of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and endothelial tyrosine kinase receptor (Tie-2) in central nervous system (CNS) hemangioblastomas (HBs) and explore the correlation with peritumoral cyst formation. METHOD: A total of 22 paraffin-embedded specimens derived from 11 cyst-associated and 11 solid solitary CNS HBs were collected for streptavidin-peroxidase immunohistochemical staining. The expression levels of Ang-1, Ang-2 and Tie-2 in cystic and solid HBs were estimated and compared according to the integrated optical density (IOD) of staining in the sections...
February 3, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28034894/the-osmopressor-induced-angiopoietin-1-secretion-in-plasma-and-subsequent-activation-of-the-tie-2-akt-enos-signaling-pathway-in-red-blood-cell
#13
You-Hsiang Chu, Chih-Cherng Lu, Tso-Chou Lin, Mei-Yung Tsou, Yu-Juei Hsu, Shung-Tai Ho, Che-Se Tung, Ching-Jiunn Tseng, Min-Hui Li, Herng-Sheng Lee
BACKGROUND: Water ingestion induces the osmopressor response, which typically presents as increased total peripheral vascular resistance in young healthy subjects. A previous study has suggested that the RBC membrane receptor is involved in osmopressor stress. Recent studies have indicated nitric oxide synthase phosphorylation in RBCs. However, the main process in signaling pathway activation to elicit such a response is unknown. Herein, we hypothesized that hypo-osmotic stress following water ingestion modulates the eNOS/NO pathway, thereby alternating vascular resistance...
December 29, 2016: American Journal of Hypertension
https://www.readbyqxmd.com/read/28010758/double-jeopardy-the-rubber-ball-bounces-twice
#14
Jack L Arbiser, Linda C Gilbert
Soblet et al. describe cis mutations in TEK/Tie-2 in blue rubber bleb nevus and sporadic vascular malformations. This suggests that the remaining normal allele is required for the phenotype. Second, it suggests therapeutic approaches to treatment signal transduction inhibition.
January 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28002269/efficacy-of-intravitreal-aflibercept-in-macular-telangiectasia-type-1-is-linked-to-the-ocular-angiogenic-profile
#15
Laura Kowalczuk, Alexandre Matet, Ali Dirani, Alejandra Daruich, Aude Ambresin, Irmela Mantel, Richard F Spaide, Natacha Turck, Francine Behar-Cohen
PURPOSE: To evaluate intravitreal aflibercept in macular telangiectasia Type 1 (MacTel 1) patients and measure their ocular angiogenic profile. METHODS: Eight subjects with MacTel 1 refractory to bevacizumab, ranibizumab, or laser therapy and switched to aflibercept were included. Best-corrected visual acuity, central macular thickness, and cystic areas quantified on optical coherence tomography B-scans were assessed during 12 months. Perifoveal capillary densities were measured on optical coherence tomography angiography...
December 20, 2016: Retina
https://www.readbyqxmd.com/read/27918469/dietary-compound-chrysin-inhibits-retinal-neovascularization-with-abnormal-capillaries-in-db-db-mice
#16
Min-Kyung Kang, Sin-Hye Park, Yun-Ho Kim, Eun-Jung Lee, Lucia Dwi Antika, Dong Yeon Kim, Yean-Jung Choi, Young-Hee Kang
Diabetic retinopathy (DR) develops in a significant proportion of patients with chronic diabetes, characterized by retinal macular edema and abnormal retinal vessel outgrowth leading to vision loss. Chrysin, a naturally-occurring flavonoid found in herb and honeycomb, has anti-inflammatory, antioxidant, and anti-cancer properties. This study sought to determine the protective effects of chrysin on retinal neovascularization with abnormal vessels and blood-retinal barrier (BRB) breakdown in 33 mM glucose-exposed human retinal endothelial cells and in db/db mouse eyes...
December 3, 2016: Nutrients
https://www.readbyqxmd.com/read/27894114/hydroxysafflor-yellow-a-promotes-angiogenesis-via-the-angiopoietin-1-tie-2-signaling-pathway
#17
Tangting Chen, Ni Chen, Ningbo Pang, Lamei Xiao, Yongjie Li, Rong Li, Mao Luo, Xin Deng, Meiping Ren, Jianbo Wu, Liqun Wang
BACKGROUND: The flowers of Carthamus tinctorius L. are widely used in traditional Chinese medicine to treat cerebrovascular and cardiovascular diseases. Hydroxysafflor yellow A (HSYA), the main constituent of C. tinctorius L. flowers, is known for its multiple biological activities. The present study investigated the effects of HSYA on angiogenesis in vitro and in a mouse hindlimb ischemia model. METHODS: Using human umbilical vein endothelial cells (HUVEC) in vitro and a mouse hindlimb ischemia model in vivo, the angiogenic role of HSYA was evaluated...
2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27893762/circulating-angiopoietin-2-and-its-soluble-receptor-tie-2-concentrations-are-related-to-renal-function-in-two-population-based-cohorts
#18
Anna Hennings, Anke Hannemann, Rainer Rettig, Marcus Dörr, Matthias Nauck, Henry Völzke, Markus M Lerch, Wolfgang Lieb, Nele Friedrich
BACKGROUND: An intact angiopoietin/Tie-2 ligand receptor system is indispensable for life. High circulating angiopoietin-2 (Ang-2) concentrations are strongly associated with kidney disease involving the progressive loss of glomerular filtration. The aim of our study was to investigate the associations between renal function and serum Ang-2 or serum Tie-2 concentrations in the general population. METHODS: Data of 3081 and 4088 subjects from two population-based studies, the Study of Health in Pomerania (SHIP-1) and SHIP-Trend, were used...
2016: PloS One
https://www.readbyqxmd.com/read/27885577/distinct-expression-of-various-angiogenesis-factors-in-mice-brain-after-whole-brain-irradiation-by-x-ray
#19
Zhezhi Deng, Haiwei Huang, Xiaohong Wu, Mengmeng Wu, Guoyong He, Junjie Guo
Radiation-induced brain injury (RBI) is the most serious complication after radiotherapy. However, the etiology of RBI remains elusive. In order to evaluate the effect of X-rays on normal brain tissue, adult male BALB/C mice were subjected to whole-brain exposure with a single dose of 10 Gy or sham radiation. The structure and number of mice brain vessels were investigated 1, 7, 30, 90 and 180 days after irradiation by H&E staining and immune-fluorescence staining. Compared with sham control mice, in addition to morphological changes, a significant reduction of microvascular density was detected in irradiated mice brains...
February 2017: Neurochemical Research
https://www.readbyqxmd.com/read/27876862/in-silico-exploration-for-novel-type-i-inhibitors-of-tie-2-tek-the-performance-of-different-selection-strategy-in-selecting-virtual-screening-candidates
#20
Peichen Pan, Huiyong Sun, Hui Liu, Dan Li, Wenfang Zhou, Xiaotian Kong, Youyong Li, Huidong Yu, Tingjun Hou
The receptor tyrosine kinase Tie-2 is involved in vessel remodeling and maturation, and has been regarded as a potential target for the treatment of various solid tumors. The absence of novel, potent and selective inhibitors severely hampers the understanding of the therapeutic potential of Tie-2. In the present work, we describe the discovery of novel type-I inhibitors of Tie-2 by structure-based virtual screening. Preliminary SAR was also performed based on one active compound, and several novel inhibitors with low micro-molar affinity were discovered...
November 23, 2016: Scientific Reports
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