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https://www.readbyqxmd.com/read/29337583/sudden-death-aversion-avoiding-superior-options-because-they-feel-riskier
#1
Jesse Walker, Jane L Risen, Thomas Gilovich, Richard Thaler
We present evidence of sudden-death aversion (SDA)-the tendency to avoid "fast" strategies that provide a greater chance of success, but include the possibility of immediate defeat, in favor of "slow" strategies that reduce the possibility of losing quickly, but have lower odds of ultimate success. Using a combination of archival analyses and controlled experiments, we explore the psychology behind SDA. First, we provide evidence for SDA and its cost to decision makers by tabulating how often NFL teams send games into overtime by kicking an extra point rather than going for the 2-point conversion (Study 1) and how often NBA teams attempt potentially game-tying 2-point shots rather than potentially game-winning 3-pointers (Study 2)...
January 15, 2018: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/29285210/discovery-and-evaluation-of-triple-inhibitors-of-vegfr-2-tie-2-and-ephb4-as-anti-angiogenic-and-anti-cancer-agents
#2
Lin Zhang, Yuanyuan Shan, Xingyue Ji, Mengyuan Zhu, Chuansheng Li, Ying Sun, Ru Si, Xiaoyan Pan, Jinfeng Wang, Weina Ma, Bingling Dai, Binghe Wang, Jie Zhang
Receptor tyrosine kinases (RTKs), especially VEGFR-2, TIE-2, and EphB4, play a crucial role in both angiogenesis and tumorigenesis. Moreover, complexity and heterogeneity of angiogenesis make it difficult to treat such pathological traits with single-target agents. Herein, we developed two classes of multi-target RTK inhibitors (RTKIs) based on the highly conserved ATP-binding pocket of VEGFR-2/TIE-2/EphB4, using previously reported BPS-7 as a lead compound. These multi-target RTKIs exhibited considerable potential as novel anti-angiogenic and anticancer agents...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221954/total-particulate-matter-from-cigarette-smoke-disrupts-vascular-development-in-zebrafish-brain-danio-rerio
#3
Andrey Massarsky, G L Prasad, Richard T Di Giulio
Several studies have demonstrated zebrafish as a useful high-throughput in-vivo model to study the effects of cigarette smoke on early development. It has been shown previously that exposure of zebrafish to cigarette smoke total particulate matter (TPM) leads to several adverse physiological aberrations, including heart deformities and improper angiogenesis. Consequently, this study investigated the effects of TPM on cardiovascular development in zebrafish that were exposed to increasing concentrations of TPM based upon nicotine content from 6h post fertilization (hpf) up to 72hpf...
December 5, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29221165/angiogenesis-in-adenosquamous-cancer-of-pancreas
#4
Nicola Silvestris, Katia Danza, Vito Longo, Oronzo Brunetti, Livia Fucci, Antonella Argentiero, Angela Calabrese, Ivana Cataldo, Roberto Tamma, Domenico Ribatti, Stefania Tommasi
Adenosquamous carcinoma of the pancreas (ASCP) is an uncommon variant of exocrine pancreatic malignancies, characterized by a histological admixture of adenomatous and squamous cell elements. This cancer is characterized by a poorly differentiated histology and a poorer clinical outcome compared to pancreatic ductal adenocarcinoma (PDAC). Unlike PDAC, that is characterized by a low microvascular density (MVD) and collapsed vasculature, no data are available about angiogenesis in ASPC. Immunohistochemical evaluation of MVD and trypatse-positive mast cells (MCs) were performed on a single case of ASCP compared to PDAC...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29180874/expression-and-significance-of-b7-h3-and-tie-2-in-the-tumor-vasculature-of-clear-cell-renal-carcinoma
#5
Xianyun Zhang, Jindong Ji, Guangbo Zhang, Chuntao Fang, Fujin Jiang, Song Ma, Jianquan Hou
Tumor angiogenesis is required for tumor growth and metastasis, and the Ang/Tie-2 axis plays a pivotal role in angiogenesis. B7-H3, a new member of the B7 family of costimulatory molecules, has a critical function in the T-cell-mediated antitumor immune response, and abnormal tumor B7-H3 expression is frequently associated with a poor prognosis. However, the relationship between B7-H3 and angiogenesis in clear cell renal carcinoma (ccRCC) remains unclear. In this study, we used immunohistochemical methods to detect tumor vascular expression of B7-H3 and Tie-2 in tissue microarrays of 82 ccRCC patient samples...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29175152/transplantation-of-human-umbilical-cord-blood-mononuclear-cells-attenuated-ischemic-injury-in-mcao-rats-via-inhibition-of-nf-%C3%AE%C2%BAb-andnlrp3inflammasome
#6
Lu Liu, Juan Cen, Yong Man, Jianbin Li, Dahuan Zhang, Fei Wang, Jinhua Li, Ji Ma, Xiaoming Wang, Biansheng Ji
Accumulated evidences displayed that transplantation of stem cells may be a promising approach for the treatment of neurological disorders. However, the underlying mechanisms remain to be well elucidated. Moreover, some investigators can not reproduce similar results as the previous. The present results showed that transplantation of fresh human umbilical cord blood mononuclear cells (cbMNCs) attenuated ischemic damage in middle cerebral artery occlusion (MCAO) rats, accompanied with improvement of neurologic deficits, learning and memory function...
November 23, 2017: Neuroscience
https://www.readbyqxmd.com/read/29132435/vasculotide-reduces-pulmonary-hyperpermeability-in-experimental-pneumococcal-pneumonia
#7
Birgitt Gutbier, Xiaohui Jiang, Kristina Dietert, Carolin Ehrler, Jasmin Lienau, Paul Van Slyke, Harold Kim, Van C Hoang, Jason T Maynes, Daniel J Dumont, Achim D Gruber, Norbert Weissmann, Timothy J Mitchell, Norbert Suttorp, Martin Witzenrath
BACKGROUND: Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality worldwide. Despite effective antimicrobial therapy, CAP can induce pulmonary endothelial hyperpermeability resulting in life-threatening lung failure due to an exaggerated host-pathogen interaction. Treatment of acute lung injury is mainly supportive because key elements of inflammation-induced barrier disruption remain undetermined. Angiopoietin-1 (Ang-1)-mediated Tie2 activation reduces, and the Ang-1 antagonist Ang-2 increases, inflammation and endothelial permeability in sepsis...
November 13, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29128541/a-pegylated-platelet-free-plasma-hydrogel-based-composite-scaffold-enables-stable-vascularization-and-targeted-cell-delivery-for-volumetric-muscle-loss
#8
Amit Aurora, Nicole Wrice, Thomas J Walters, Robert J Christy, Shanmugasundaram Natesan
Extracellular matrix (ECM) scaffolds are being used for the clinical repair of soft tissue injuries. Although improved functional outcomes have been reported, ECM scaffolds show limited tissue specific remodeling response with concomitant deposition of fibrotic tissue. One plausible explanation is the regression of blood vessels which may be limiting the diffusion of oxygen and nutrients across the scaffold. Herein we develop a composite scaffold as a vasculo-inductive platform by integrating PEGylated platelet free plasma (PFP) hydrogel with a muscle derived ECM scaffold (m-ECM)...
November 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29104145/the-dual-effects-of-a-novel-peptibody-on-angiogenesis-inhibition-and-m2-macrophage-polarization-on-sarcoma
#9
Xiaoqing Zhu, Jiali Yang, Yanfeng Gao, Chunjing Wu, Lili Yi, Guodong Li, Yuanming Qi
Inhibition of the VEGF/VEGF receptor (VEGFR) and angiopoietin-2 (Ang-2)/TEK receptor tyrosine kinase (Tie-2) pathway is a potential target for tumor angiogenesis. We previously showed that a peptide AS16 which dually inhibits VEGFR/Ang-2 could reduce the tumor growth and decrease the number of microvessels in tumor. However, its short circulating half-life in the serum limits its clinical applications. In this study, as an effort to prolong the short in vivo half-life of AS16, we designed a fusion protein containing peptide AS16 and an IgG Fc fragment...
November 2, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29102175/discovery-of-novel-anti-angiogenesis-agents-part-7-multitarget-inhibitors-of-vegfr-2-tie-2-and-ephb4
#10
Chuansheng Li, Yuanyuan Shan, Ying Sun, Ru Si, Liyuan Liang, Xiaoyan Pan, Binghe Wang, Jie Zhang
Herein, we embarked on a structural optimization campaign aiming at the discovery of second generation anti-angiogenesis agents with our previously reported BPS-7 as lead compound. A library of 27 compounds has been afforded based on the highly conserved ATP-binding pocket of VEGFR-2, Tie-2, and EphB4. Several title compounds exhibited simultaneous inhibitory effects against three angiogenic RTKs. These compounds with a 'triplet' inhibition profile have been identified as novel anti-angiogenic and anticancer agents...
December 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29073721/microrna-381-induced-down-regulation-of-cxcr4-promotes-the-proliferation-of-renal-tubular-epithelial-cells-in-rat-models-of-renal-ischemia-reperfusion-injury
#11
Gui-Hong Zheng, Xin Wen, Yong-Jian Wang, Xin-Rui Han, Qun Shan, Wang Li, Tian Zhao, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
This study aims to explore whether microRNA-381 (miR-381) mediating CXCR4 affects the renal tubular epithelial cells (RTEC) of renal ischemia reperfusion (I/R) injury. Forty-eight rats were assigned into the I/R (n = 24, successfully established as I/R model) and sham (n = 24) groups. After collecting kidney tissues, immunohistochemistry and microvascular density (MVD) counting were conducted for CXCR4 positive expression and MVD numbers. RTECs were assigned into the sham, blank, negative control (NC), miR-381 mimics, miR-381 inhibitor, si-CXCR4, and miR-381 inhibitor + si-CXCR4 groups...
October 26, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29066268/do-skin-lacerations-imply-tissue-transfer-from-surgeon-to-patient-during-arthroscopic-knot-tying
#12
Matthew B Burn, Heidi L Holtorf, Kevin M Smith, Derek T Bernstein, Domenica A Delgado, Nickarr Prudhomme, Michael T Deavers, Patrick C McCulloch, Joshua D Harris
PURPOSE: To use simulated arthroscopic knot tying to assess (1) whether epithelial cells from the surgeon's hands were transmitted to the suture and (2) whether the number of knots tied or the presence of glove tears would correlate with the number of cells transmitted. METHODS: Knots were tied in a simulated arthroscopic environment using a nonabsorbable No. 2 suture over a metal hook. The surgeon was double gloved for each knot tied. For each "anchor," a surgeon's knot was tied, followed by 3 reversed half-hitches on alternating posts...
October 21, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29050231/a-phase-i-study-of-foretinib-plus-erlotinib-in-patients-with-previously-treated-advanced-non-small-cell-lung-cancer-canadian-cancer-trials-group-ind-196
#13
Natasha B Leighl, Ming-Sound Tsao, Geoffrey Liu, Dongsheng Tu, Cheryl Ho, Frances A Shepherd, Nevin Murray, John R Goffin, Garth Nicholas, Shingo Sakashita, Zhuo Chen, Lucia Kim, Jean Powers, Lesley Seymour, Glenwood Goss, Penelope A Bradbury
PURPOSE: MET and AXL mediate resistance to EGFR TKI in NSCLC. Foretinib, a MET/RON/AXL/TIE-2/VEGFR kinase inhibitor may overcome EGFR kinase resistance. This dose escalation study combined foretinib and erlotinib in advanced pretreated NSCLC patients. EXPERIMENTAL DESIGN: The primary endpoint was to define the RP2D of foretinib plus erlotinib as continuous oral daily dosing. Secondary objectives included safety, pharmacokinetics, response and potential biomarkers of response including EGFR, KRAS genotype, MET, AXL expression, and circulating HGF levels...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29032031/discovery-of-novel-anti-angiogenesis-agents-part-8-diaryl-thiourea-bearing-1h-indazole-3-amine-as-multi-target-rtks-inhibitors
#14
Ying Sun, Yuanyuan Shan, Chuansheng Li, Ru Si, Xiaoyan Pan, Binghe Wang, Jie Zhang
VEGFR-2, TIE-2, and EphB4 are essential for both angiogenesis and tumorigenesis. Herein, we designed and prepared three classes of multi-target inhibitors based on the extensive sequence homology along the kinase domain of angiogenic RTKs. Biological evaluation indicated that these multi-target inhibitors exhibited considerable potential as novel anti-angiogeneic and anticancer agents. Among them, a diaryl thiourea bearing 1H-indazole-3-amine (16a) displayed the most potent RTK inhibition and excellent selectivity...
December 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28987818/the-anti-apoptotic-effect-of-fluid-mechanics-preconditioning-by-cells-membrane-and-mitochondria-in-rats-brain-microvascular-endothelial-cells
#15
Shan Tian, Fengping Zhu, Ruiping Hu, Song Tian, Xingxing Chen, Dan Lou, Bing Cao, Qiulei Chen, Bai Li, Fang Li, Yulong Bai, Yi Wu, Yulian Zhu
Exercise preconditioning is a simple and effective way to prevent ischemia. This paper further provided the mechanism in hemodynamic aspects at the cellular level. To study the anti-apoptotic effects of fluid mechanics preconditioning, Cultured rats brain microvascular endothelial cells were given fluid intervention in a parallel plate flow chamber before oxygen glucose deprivation. It showed that fluid mechanics preconditioning could inhibit the apoptosis of endothelial cells, and this process might be mediated by the shear stress activation of Tie-2 on cells membrane surface and Bcl-2 on the mitochondria surface...
October 5, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28979738/role-of-angiopoietins-and-tie-2-in-diabetic-retinopathy
#16
Nervana Khalaf, Hazem Helmy, Hany Labib, Iman Fahmy, Mona Abd El Hamid, Leqaa Moemen
OBJECTIVE: The aim of this study was to determine the serum levels of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), soluble vascular endothelial tyrosine kinase receptor (Tie-2) and vascular endothelial growth factor (VEGF), in the serum of type 2 diabetic patients having non-proliferative (NPDR) or proliferative diabetic retinopathy (PDR). METHODS: One hundred patients with type 2 diabetes mellitus were involved in this cross-sectional study. They were classified into 25 diabetic patients without retinopathy, 35 patients with NPDR and 40 PDR patients...
August 2017: Electronic Physician
https://www.readbyqxmd.com/read/28967470/involvement-of-synovial-matrix-degradation-and-angiogenesis-in-oxidative-stress-exposed-degenerative-rotator-cuff-tears-with-osteoarthritis
#17
Kyu-Cheol Noh, Sin-Hye Park, Cheol Jung Yang, Geun Woo Lee, Min Ki Kim, Young-Hee Kang
BACKGROUND: Shoulder osteoarthritis is a gradual wearing of the articular cartilage concomitant with degenerative rotator cuff tears (RCTs). This pathologic disorder is related to inflammation, oxidative stress, and angiogenesis. Degenerative alterations may prompt production of cytokines and angiogenesis-related proteins, evoking rotator cuff diseases. This study tested the hypothesis that oxidative stress-responsive mediators can influence joint inflammation of patients with RCT. METHODS: Twelve healthy RCT patients not suffering shoulder osteoarthritis were categorized as the control group, and 24 patients were allocated to 2 RCT groups (RCTP1 and RCTP2), according to severity of RCT and glenohumeral arthritis...
January 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28956197/bone-marrow-sinusoidal-endothelium-damage-and-potential-regeneration-following-cancer-radiotherapy-or-chemotherapy
#18
REVIEW
Mohammadhossein Hassanshahi, Alireza Hassanshahi, Samira Khabbazi, Yu-Wen Su, Cory J Xian
It is very well known that bone marrow (BM) microvasculature may possess a crucial role in the maintenance of homeostasis of BM due to mutual interactions between BM microvascular system and other physiological functions including haematopoiesis and osteogenesis. Chemotherapy and radiotherapy are known as main approaches for cancer treatment and also are known as the main cause of damage to the BM microvascular system. However, despite the importance of BM microvasculature in orchestrating various biological functions, less attention has been drawn to address the underlying mechanisms for the damage and to explore cellular and molecular mechanisms by which the recovery/regeneration of chemotherapy- and/or radiotherapy-induced BM microvascular system damage can occur...
November 2017: Angiogenesis
https://www.readbyqxmd.com/read/28925558/endothelial-precursor-cell-cross-match-using-tie-2-enriched-spleen-cells
#19
Volker Daniel, Caner Süsal, Sabine Scherer, Hien Tran, Petra Gombos, Karina Trojan, Mahmoud Sadeghi, Christian Morath, Gerhard Opelz
BACKGROUND: Non-HLA antibodies against human endothelial progenitor cells (EPC) in pre-transplant recipient serum can have a deleterious influence on the graft. EPC enriched from peripheral blood have been commonly used for EPC cross-matching. In the present study, we describe cross-matches using EPC enriched from fresh or frozen-thawed spleen cell preparations, thereby widening the sample source for deceased-donor cross-matching and retrospective studies. METHODS: EPC cross-matches were performed retrospectively using spleen cells and the flow cytometric XM-ONE cross-match test kit...
September 19, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28918499/the-levels-of-circulating-proangiogenic-factors-in-migraineurs
#20
Slawomir Michalak, Alicja Kalinowska-Lyszczarz, Danuta Wegrzyn, Anna Thielemann, Krystyna Osztynowicz, Wojciech Kozubski
Migraine has been reported as a risk factor for ischemic stroke or cardiovascular events, and dysfunction of endothelial cells has been evidenced in migraine patients. Proangiogenic factors are potential endothelial stimulators, and their disturbances can link abnormalities of endothelium with increased risk of vascular disorders. The aim of this study was to evaluate the levels of circulating proangiogenic factors in sera of migraineurs during interictal period. Fifty-two patients aged 37.9 ± 9.6 years, fulfilling International Headache Society criteria for migraine, were included in this observational case-control study...
December 2017: Neuromolecular Medicine
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