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https://www.readbyqxmd.com/read/29778054/at-risk-symptoms-of-bipolar-disorder-in-a-university-student-cohort
#1
Ida S Haussleiter, Sandra Lorek, Eike Zeschel, Svenja Mattausch, Milena Meyers, Georg Juckel
To assess the occurrence and frequency of bipolar at-risk symptoms in a large sample of previously undiagnosed students using the new screening tool Bochumer Screeningbogen Bipolar (BSB). 2329 students of the Ruhr-University Bochum, Germany completed online demographic data as well as various self-rating questionnaires (BSB; Hypomania Checklist 32; Altman Self-Rating Mania Scale; Beck Depression Inventory). Within the student cohort (64.4% female, mean age 24.3 years) every fifth student currently suffered from moderate to severe depressive symptoms; every sixth student had already thought about suicide and every other student reported a history of mood swings...
May 6, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29777607/optimizing-charge-state-distribution-is-a-prerequisite-for-accurate-protein-biomarker-quantification-with-lc-ms-ms-as-illustrated-by-hepcidin-measurement
#2
Ellen M H Schmitz, Niels M Leijten, Joost L J van Dongen, Maarten A C Broeren, Lech G Milroy, Luc Brunsveld, Volkher Scharnhorst, Daan van de Kerkhof
BACKGROUND: Targeted quantification of protein biomarkers with liquid chromatography-tandem mass spectrometry (LC-MS/MS) has great potential, but is still in its infancy. Therefore, we elucidated the influence of charge state distribution and matrix effects on accurate quantification, illustrated by the peptide hormone hepcidin. METHODS: An LC-MS/MS assay for hepcidin, developed based on existing literature, was improved by using 5 mM ammonium formate buffer as mobile phase A and as an elution solution for solid phase extraction (SPE) to optimize the charge state distribution...
May 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29777403/correction-to-clinical-outcomes-and-evaluation-of-laparoscopic-proximal-gastrectomy-with-double-flap-technique-for-early-gastric-cancer-in-the-upper-third-of-the-stomach
#3
Masaru Hayami, Naoki Hiki, Souya Nunobe, Shinji Mine, Manabu Ohashi, Koshi Kumagai, Satoshi Ida, Masayuki Watanabe, Takeshi Sano, Toshiharu Yamaguchi
In the original article on page 1636, first line, the reference cited for Kamikawa et al. is incorrect. The correct reference is as follows: Kamikawa YKT, Kamiyama S, Satomoto K. A new procedure of esophagogastrostomy to prevent reflux following proximal gastrectomy (in Japanese). Shoukakigeka. 2001;24:1053-60.
May 17, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29777197/the-transition-state-structure-for-binding-between-taz1-of-cbp-and-the-disordered-hif-1%C3%AE-cad
#4
Ida Lindström, Eva Andersson, Jakob Dogan
Intrinsically disordered proteins (IDPs) are common in eukaryotes. However, relatively few experimental studies have addressed the nature of the rate-limiting transition state for the coupled binding and folding reactions involving IDPs. By using site-directed mutagenesis in combination with kinetics measurements we have here characterized the transition state for binding between the globular TAZ1 domain of CREB binding protein and the intrinsically disordered C-terminal activation domain of Hif-1α (Hif-1α CAD)...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29775614/tumor-dependent-secretion-of-close-homolog-of-l1-results-in-elevation-of-its-circulating-level-in-mouse-model-for-human-lung-tumor
#5
Norihiro Kotani, Yui Ida, Takanari Nakano, Izumi Sato, Ryusuke Kuwahara, Arisa Yamaguchi, Masahiro Tomita, Koichi Honke, Takayuki Murakoshi
Close homolog of L1 (CHL1) and its truncated form mainly play crucial roles in mouse brain development and neural functions. Herein, we newly identified that truncated form of CHL1 is produced and released from lung tumor tissue in a mouse model expressing human EML4-ALK fusion gene. Both western blot and direct ELISA analysis revealed that mouse CHL1 level in serum (including serum extracellular vesicles) was significantly elevated in EML4-ALK transgenic mice. The correlation between the tumor size and the amount of CHL1 secretion could be examined in this study, and showed a significant positive correlation in a tumor size-dependent manner...
May 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29774712/-diagnostic-imaging-procedures-and-prescribing-appropriateness-are-administrative-data-a-proper-instrument-an-experience-from-piedmont-region-northern-italy
#6
Eva Pagano, Laura Crosetto, Andrea Evangelista, Chiara Monagheddu, Ottavio Davini, Giulio Fornero, Ida Raciti, Guido Giustetto, Giovannino Ciccone
OBJECTIVES: to assess at population level if healthcare administrative data can be suitable to identify variability and determinants of the prescribing rates for some diagnostic imaging procedures at high-risk of inappropriateness. DESIGN: population-based observational study. SETTING AND PARTICIPANTS: Piedmont Region (Northern Italy) adult population (>20 years) in year 2013. The subjects included were 3,566,147, referring to 3,016 general practitioners (GPs), in 12 Local Health Authorities (LHAs)...
March 2018: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29772815/longitudinal-effects-of-iron-deficiency-anemia-and-subsequent-repletion-on-blood-parameters-and-the-rate-and-composition-of-growth-in-pigs
#7
Laura C Knight, Ryan N Dilger
Iron deficiency is reported as the most common nutrient deficiency worldwide. Due to rapid growth, infants are at particular risk for developing iron deficiency, which can easily progress to iron deficiency anemia (IDA), if not treated. The aim of this study was to determine the lasting effects of an early-life iron deficiency after a period of dietary iron repletion. Forty-two intact male pigs were fed, ad libitum , either control (CONT, 21.3 mg Fe/L) or iron-deficient (ID 2.72 mg Fe/L) milk replacer from postnatal day (PND) 2 to 32 (phase 1)...
May 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29772348/biosafety-stability-and-osteogenic-activity-of-novel-implants-made-of-zr-70-ni-16-cu-6-al-8-bulk-metallic-glass-for-biomedical-application
#8
Hiroto Ida, Masahiro Seiryu, Nobuo Takeshita, Masanari Iwasaki, Yoshihiko Yokoyama, Yusuke Tsutsumi, Etsuko Ikeda, Satoshi Sasaki, Shunro Miyashita, Shutaro Sasaki, Tomohiro Fukunaga, Toru Deguchi, Teruko Takano-Yamamoto
Superior mechanical and chemical properties of Zr70 Ni16 Cu6 Al8 bulk metallic glass (BMG) demonstrate its promise as a novel biomaterial for fabrication of implants. The aim of the present study was to validate mechanical, chemical, and biological properties of Zr70 Ni16 Cu6 Al8 BMG through comparison with titanium (Ti). Our data indicated higher tensile strength, lower Young's modulus, and reduced metal ion release of Zr70 Ni16 Cu6 Al8 BMG compared with Ti. Biosafety of bone marrow mesenchymal cells on Zr70 Ni16 Cu6 Al8 BMG was comparable to that of Ti...
May 14, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29771827/the-influence-of-socioeconomic-factors-on-the-epidemiology-of-maxillofacial-fractures-in-southern-italy
#9
Carolina Sbordone, Ida Barca, Marzia Petrocelli, Giovanni Dell'Aversana Orabona, Luigi Angelo Vaira, Walter Colangeli, Maria Giulia Cristofaro, Mario Giudice, Amerigo Giudice, Francesco Maria Cassandro, Federica Attanasi, Giorgio Iaconetta, Luigi Califano
Maxillofacial fractures represent a serious public health problem. Their epidemiology is extremely variable and its analysis is crucial to establish effective treatment and prevention of these injuries. The aim of this multicentric retrospective study was to analyze causes, demographics, incidence, characteristics of 987 patients diagnosed with maxillofacial trauma between 2011 and 2015 at Complex Operative Unit of Maxillofacial Surgery of Federico II University of Naples and Magna Graecia University of Catanzaro, Italy; 657 male and 310 female patients were admitted in the study...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29770846/peripheral-vs-pedicle-division-in-laparoscopic-resection-of-sigmoid-diverticulitis-a-10-year-experience
#10
Alberto Posabella, Niccolò Rotigliano, Athanasios Tampakis, Markus von Flüe, Ida Füglistaler
PURPOSE: Laparoscopic rectosigmoid resection is the standard surgical treatment for recurrent sigmoid diverticulitis. However, speaking of mesenterium division, no unique standard procedure is actually provided. Surgeons can perform it at the level of either the sigmoid vessels or the inferior mesenteric vessels. The objective of this study was to compare intra- and postoperative complications of both techniques. METHODS: From a prospective collected database of patients that underwent elective laparoscopic sigmoid resection between January 2004 and December 2014, a retrospective analysis according to the selected operative technique was performed...
May 17, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29767699/impact-of-double-fortified-salt-with-iron-and-iodine-on-hemoglobin-anemia-and-iron-deficiency-anemia-a-systematic-review-and-meta-analysis
#11
María J Ramírez-Luzuriaga, Leila M Larson, Venkatesh Mannar, Reynaldo Martorell
Double-fortified salt (DFS) containing iron and iodine has been proposed as a feasible and cost-effective alternative for iron fortification in low- and middle-income countries (LMICs). We conducted a systematic review and meta-analysis from randomized and quasi-randomized controlled trials to 1) assess the effect of DFS on biomarkers of iron status and the risk of anemia and iron deficiency anemia (IDA) and 2) evaluate differential effects of DFS by study type (efficacy or effectiveness), population subgroups, iron formulation (ferrous sulfate, ferrous fumarate, and ferric pyrophosphate), iron concentration, duration of intervention, and study quality...
May 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29767387/no-medication-for-my-child-a-naturalistic-study-on-the-treatment-preferences-for-and-effects-of-cogmed-working-memory-training-versus-psychostimulant-medication-in-clinically-referred-youth-with-adhd
#12
Peter Muris, Dorien Roodenrijs, Lut Kelgtermans, Sonja Sliwinski, Ulrike Berlage, Hanna Baillieux, Anne Deckers, Marieke Gunther, Bertien Paanakker, Ida Holterman
In this naturalistic clinical study, we explored the applicability and clinical effectiveness of Cogmed WMT, pharmacotherapy, and their combination for clinically referred children and adolescents with attention-deficit/hyperactivity disorder (ADHD). Ninety youth with ADHD (ages 6-16 years) and their parents were offered the possibility to choose one of the three interventions. The motives for choosing various interventions were quite different. Medication was chosen because this treatment was expected to be most effective, but also because the Cogmed WMT program was regarded as too taxing...
May 16, 2018: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/29767103/comparative-methane-estimation-from-cattle-based-on-total-co-2-production-using-different-techniques
#13
Md N Haque, Hanne H Hansen, Ida M L D Storm, Jørgen Madsen
The objective of this study was to compare the precision of CH4 estimates using calculated CO2 (HP) by the CO2 method (CO2 T) and measured CO2 in the respiration chamber (CO2 R). The CO2 R and CO2 T study was conducted as a 3 × 3 Latin square design where 3 Dexter heifers were allocated to metabolic cages for 3 periods. Each period consisted of 2 weeks of adaptation followed by 1 week of measurement with the CO2 R and CO2 T. The average body weight of the heifer was 226 ± 11 kg (means ± SD). They were fed a total mixed ration, twice daily, with 1 of 3 supplements: wheat (W), molasses (M), or molasses mixed with sodium bicarbonate (Mbic)...
June 2017: Animal nutrition
https://www.readbyqxmd.com/read/29766627/cocatalyst-stabilizes-a-hydride-intermediate-during-photocatalytic-hydrogen-evolution-over-rhodium-doped-tio2-nanosheet
#14
Shintaro Ida, Kenta Sato, Tetsuya Nagata, Hidehisa Hagiwara, Motonori Watanabe, Kim Namhoon, Yoshihito Shiota, Michio Koinuma, Sakae Takenaka, Elif Ertekin, Tatsumi Ishiihara
The hydrogen evolution reaction using semiconductor photocatalysts has been significantly improved by cocatalyst loading. However, there are still many speculations regarding the actual role of the cocatalyst. Here we report a photocatalytic hydrogen evolution reaction pathway on a cocatalyst site using TiO2 nanosheets doped with Rh at Ti sites as one-atom cocatalysts. A hydride species adsorbed on the one-atom Rh dopant cocatalyst site was confirmed experimentally as the intermediate state for hydrogen evolution, which was consistent with the results of density functional theory (DFT) calculations...
May 15, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29766375/efficacy-of-adalimumab-and-infliximab-in-recalcitrant-retinal-vasculitis-inadequately-responsive-to-other-immunomodulatory-therapies
#15
Claudia Fabiani, Jurgen Sota, Donato Rigante, Antonio Vitale, Giacomo Emmi, Giuseppe Lopalco, Lorenzo Vannozzi, Silvana Guerriero, Alice Bitossi, Ida Orlando, Rossella Franceschini, Bruno Frediani, Mauro Galeazzi, Florenzo Iannone, Gian Marco Tosi, Luca Cantarini
The primary aim of the study was to evaluate the efficacy of tumor necrosis factor (TNF)-α blockers adalimumab (ADA) and infliximab (IFX) in refractory sight-threatening retinal vasculitis (RV) during a 12-month follow-up period. Secondary aims were to evaluate (i) any impact of concomitant conventional disease-modifying anti-rheumatic drugs (cDMARDs) and different lines of biologic therapy; (ii) any difference in terms of efficacy between ADA and IFX; (iii) consequences of biotherapies on the best-corrected visual acuity (BCVA); (iv) corticosteroid-sparing effect; and (vi) ocular complications during anti-TNF-α treatment...
May 15, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29765172/dietary-sucrose-regulates-the-expression-of-the-cd36-gene-in-hepatic-tissue-of-rats-with-obesity-and-non-alcoholic-fatty-liver-disease-nafld
#16
Rodolfo Quintana Castro, Ida Soto Rodriguez, Rosa A Deschamps Lago, Peter Grube Pagola, Jorge Rodriguez Antolin, Adriana Peres Quintal, Jaime Rivera Rivera, Alfonso Alexander Aguilera
AIM: To evaluate the mRNA expression levels of Cd36 in adipose and hepatic tissues, in rats with NAFLD after the consumption of sucrose for 10 and 20 weeks. METHODS: Twenty Wistar rats, all nearly 21 days old were divided into two experimental groups (NAFLD-10 and NAFLD-20), that received a standard diet (2014 Teklad Global) plus 30% sucrose in their drinking water for 10 and 20 weeks and the control groups (C Groups). Variables such as body weight, food intakes, and serum parameters were measured...
May 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29764408/congenital-rhabdomyosarcoma-a-different-clinical-presentation-in-two-cases
#17
Ida Russo, Virginia Di Paolo, Carmelo Gurnari, Angela Mastronuzzi, Francesca Del Bufalo, Pier Luigi Di Paolo, Angela Di Giannatale, Renata Boldrini, Giuseppe Maria Milano
BACKGROUND: Rhabdomyosarcoma (RMS), one of the most common soft tissue sarcomas of childhood, is very rare in the neonatal period (0.4-2% of cases). In order to gain a deeper understanding of this disease at such age, patient and tumor features, as well as treatment modality and outcome need to be reported. CASE PRESENTATION: We describe two cases with congenital RMS treated at Bambino Gesù Children's Hospital between 2000 and 2016. They represent only 2.24% of all RMS patients diagnosed during that period in our Institution; this data is in agreement with the incidence reported in the literature...
May 15, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29761778/-the-relation-between-depression-and-inflammation
#18
Lasse Fisker, Ole Köhler-Forsberg, Ida Hageman
Accumulating evidence suggests, that inflammatory processes contribute to the pathophysiology of major depressive disorder. Subgroups of patients have elevated plasma levels of pro-inflammatory cytokines, which seem to normalise in response to conventional antidepressive treatment. In this review of the current studies on the relation between depression and inflammation we discuss possible future directions for individualised treatment of major depressive disorder.
May 14, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29761498/storage-lipid-accumulation-is-controlled-by-photoperiodic-signal-acting-via-regulators-of-growth-cessation-and-dormancy-in-hybrid-aspen
#19
Åsa Grimberg, Ida Lager, Nathaniel R Street, Kathryn M Robinson, Salla Marttila, Niklas Mähler, Pär K Ingvarsson, Rishikesh P Bhalerao
The signalling pathways that control seasonal modulation of carbon metabolism in perennial plants are poorly understood. Using genetic, metabolic and natural variation approaches, we identify factors mediating photoperiodic control of storage lipid accumulation in the model tree hybrid aspen (Populus tremula × tremuloides). We characterized lipid accumulation in transgenic hybrid aspen with impaired photoperiodic and hormonal responses. Genome-wide association mapping was performed in Swedish aspen (P. tremula) genotypes to determine genetic loci associated with genotype variation in lipid content...
May 15, 2018: New Phytologist
https://www.readbyqxmd.com/read/29760936/preliminary-molecular-evidence-associating-a-novel-brca1-synonymous-variant-with-hereditary-ovarian-cancer-syndrome
#20
Angelo Minucci, Paola Concolino, Maria De Bonis, Alessandra Costella, Ida Paris, Giovanni Scambia, Ettore Capoluongo
Extensive molecular screening of the BRCA1/2 ( BRCA) genes by massively parallel sequencing (MPS) identified variants of uncertain (or unknown) significance (VUS) and novel variants. We performed a molecular characterization of a novel BRCA1 synonymous variant discovered in a family with hereditary ovarian cancer (HOC) syndrome. We showed that the BRCA1 c.5073   A  > T variant might play a pathogenic role in HOC syndrome in this family.
2018: Human Genome Variation
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