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https://www.readbyqxmd.com/read/28346013/the-physiology-of-blood-loss-and-shock-new-insights-from-a-human-laboratory-model-of-hemorrhage
#1
Alicia M Schiller, Jeffrey T Howard, Victor A Convertino
The ability to quickly diagnose hemorrhagic shock is critical for favorable patient outcomes. Therefore, it is important to understand the time course and involvement of the various physiological mechanisms that are active during volume loss and that have the ability to stave off hemodynamic collapse. This review provides new insights about the physiology that underlies blood loss and shock in humans through the development of a simulated model of hemorrhage using lower body negative pressure. In this review, we present controlled experimental results through utilization of the lower body negative pressure human hemorrhage model that provide novel insights on the integration of physiological mechanisms critical to the compensation for volume loss...
April 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28345969/foot-ulceration-in-patients-with-diabetes-a-risk-analysis
#2
Mariana Angela Rossaneis, Maria do Carmo Fernandez Lourenço Haddad, Maria de Fátima Mantovani, Sonia Silva Marcon, Paloma de Souza Cavalcante Pissinati
The study reported in this article aimed to analyse factors associated with the risk of ulceration in the feet of patients with diabetes using a conceptual hierarchic model. It was a cross-sectional study carried out with 1515 people with diabetes mellitus aged 40 years and older. The risk of foot ulceration was of higher significance in male patients with diabetes (adjusted odds ratio (OR)=1.39 (95% confidence interval (CI) 1.11 to 1.73); p=0.020), who did not practise a regular physical activity (adjusted OR=1...
March 23, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28344673/is-rumination-a-risk-and-a-protective-factor
#3
Kaitlin A Harding, Amy Mezulis
High trait positive affect (PA) protects against depressive symptoms through cognitive responses such as rumination. However, how rumination in response to positive emotions (positive rumination) protects against depressive symptoms while rumination in response to negative emotions (brooding) predicts depressive symptoms is poorly understood. We hypothesized that (a) positive rumination and brooding represent a shared cognitive process of affect amplification on distinct affective content and (b) less brooding and greater positive rumination would distinctly mediate greater trait PA in predicting fewer depressive symptoms...
March 2017: Europe's journal of psychology
https://www.readbyqxmd.com/read/28343209/terminological-collocations-in-medical-latin-and-english-a-comparative-study
#4
Olena M Bieliaieva, Yuliia V Lysanets, Ivanna V Znamenska, Inesa V Rozhenko, Nataliia M Nikolaieva
INTRODUCTION: The present paper examines the linguistic status of terminological collocations in medical Latin and English, discusses the most productive term-formation models and ways of Latin-English translation. AIM: The authors aim to provide the comparative analysis of Latin and English terminological collocations and suggest their classification in terms of the idiomaticity level and semantic valency. MATERIALS AND METHODS: The research is based on the corpus of terminological collocations in Latin and English medical discourse using structural, etymological, typological, comparative methods, as well as the method of semantic analysis and conceptual metaphor theory...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28341479/a-method-for-independent-modelling-in-support-of-regulatory-review-of-dose-assessments
#5
Björn Dverstorp, Shulan Xu
Several countries consider geological disposal facilities as the preferred option for spent nuclear fuel due to their potential to provide isolation from the surface environment on very long timescales. In 2011 the Swedish Nuclear Fuel & Waste Management Co. (SKB) submitted a license application for construction of a spent nuclear fuel repository. The disposal method involves disposing spent fuel in copper canisters with a cast iron insert at about 500 m depth in crystalline basement rock, and each canister is surrounded by a buffer of swelling bentonite clay...
March 22, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28340338/a-phase-separation-model-for-transcriptional-control
#6
REVIEW
Denes Hnisz, Krishna Shrinivas, Richard A Young, Arup K Chakraborty, Phillip A Sharp
Phase-separated multi-molecular assemblies provide a general regulatory mechanism to compartmentalize biochemical reactions within cells. We propose that a phase separation model explains established and recently described features of transcriptional control. These features include the formation of super-enhancers, the sensitivity of super-enhancers to perturbation, the transcriptional bursting patterns of enhancers, and the ability of an enhancer to produce simultaneous activation at multiple genes. This model provides a conceptual framework to further explore principles of gene control in mammals...
March 23, 2017: Cell
https://www.readbyqxmd.com/read/28338920/dendritic-cell-expression-of-the-signaling-molecule-traf6-is-required-for-immune-tolerance-in-the-lung
#7
Daehee Han, Matthew C Walsh, Kwang Soon Kim, Sung-Wook Hong, Junyoung Lee, Jaeu Yi, Gloriany Rivas, Yongwon Choi, Charles D Surh
Immune tolerance in the lung is important for preventing hypersensitivity, such as allergic asthma. Maintenance of tolerance in the lung is established by coordinated activities of poorly understood cellular and molecular mechanisms, including participation of dendritic cells (DCs). We have previously identified DC expression of the signaling molecule TRAF6 as a non-redundant requirement for the maintenance of immune tolerance in the small intestine of mice. Because mucosal tissues share similarities in how they interact with exogenous antigens, we examined the role of DC-expressed TRAF6 in the lung...
March 11, 2017: International Immunology
https://www.readbyqxmd.com/read/28337687/assessing-the-culture-of-residency-using-the-c-change-resident-survey-validity-evidence-in-34-u-s-residency-programs
#8
Linda H Pololi, Arthur T Evans, Janet T Civian, Sandy Shea, Robert T Brennan
BACKGROUND: A practical instrument is needed to reliably measure the clinical learning environment and professionalism for residents. OBJECTIVE: To develop and present evidence of validity of an instrument to assess the culture of residency programs and the clinical learning environment. DESIGN: During 2014-2015, we surveyed residents using the C - Change Resident Survey to assess residents' perceptions of the culture in their programs. PARTICIPANTS: Residents in all years of training in 34 programs in internal medicine, pediatrics, and general surgery in 14 geographically diverse public and private academic health systems...
March 23, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28335444/hiv-education-and-welfare-services-in-primary-care-an-empirical-model-of-integration-in-brazil-s-unified-health-system
#9
Rahbel Rahman, Rogério M Pinto, Melanie M Wall
Integration of health education and welfare services in primary care systems is a key strategy to solve the multiple determinants of chronic diseases, such as Human Immunodeficiency Virus Infection and Acquired Immune Deficiency Syndrome (HIV/AIDS). However, there is a scarcity of conceptual models from which to build integration strategies. We provide a model based on cross-sectional data from 168 Community Health Agents, 62 nurses, and 32 physicians in two municipalities in Brazil's Unified Health System (UHS)...
March 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28335381/computational-prediction-of-the-protonation-sites-of-ac-lys-ala-n-lys-nh2-peptides-through-conceptual-dft-descriptors
#10
Sebastián Sastre, Juan Frau, Daniel Glossman-Mitnik
Six density functionals (M11, M11L, MN12L, MN12SX, N12, and N12SX) in connection with the Def2TZVP basis set and the SMD solvation model (water as a solvent) have been assessed for the calculation of the molecular structure and properties of several peptides with the general formulaAc-Lys-(Ala)n-Lys-NH2,withn=0to5  [...].
March 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28332052/the-varieties-of-character-and-some-implications-for-character-education
#11
Jason Baehr
The moral and civic dimensions of personal character have been widely recognized and explored. Recent work by philosophers, psychologists, and education theorists has drawn attention to two additional dimensions of character: intellectual character and "performance" character. This article sketches a "four-dimensional" conceptual model of personal character and some of the character strengths or "virtues" proper to each dimension. In addition to exploring how the dimensions of character are related to each other, the article also examines the implications of this account for character education undertaken in a youth or adolescent context...
March 22, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28332013/quality-of-life-of-the-very-old-survey-on-quality-of-life-and-subjective-well-being-of-the-very-old-in-north-rhine-westphalia-nrw80
#12
Michael Wagner, Christian Rietz, Roman Kaspar, Anna Janhsen, Luise Geithner, Michael Neise, Carolin Kinne-Wall, Christiane Woopen, Susanne Zank
BACKGROUND: In Germany, the very old are the most rapidly growing proportion of the population. A comprehensive investigation of the conditions for a good quality of life in this group is relevant for both society and politics. OBJECTIVE: The project "Quality of life and subjective well-being of the very old in North Rhine-Westphalia" (NRW80+) at the University of Cologne surveys quality of life of the very old. Taking into account many specific methodological and theoretical challenges, it aims at setting up a specific theoretical framework and methodological approach...
March 22, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28331596/credit-of-ecological-interactions-a-new-conceptual-framework-to-support-conservation-in-a-defaunated-world
#13
Luísa Genes, Bruno Cid, Fernando A S Fernandez, Alexandra S Pires
As defaunation spreads through the world, there is an urgent need for restoring ecological interactions, thus assuring ecosystem processes. Here, we define the new concept of credit of ecological interactions, as the number of interactions that can be restored in a focal area by species colonization or reintroduction. We also define rewiring time, as the time span until all the links that build the credit of ecological interactions of a focal area have become functional again. We expect that the credit will be gradually cashed following refaunation in rates that are proportional to (1) the abundance of the reintroduced species (that is expected to increase in time since release), (2) the abundance of the local species that interact with them, and (3) the traits of reintroduced species...
March 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28330453/a-systematic-review-of-primary-care-models-for-non-communicable-disease-interventions-in-sub-saharan-africa
#14
Jennifer Kane, Megan Landes, Christopher Carroll, Amy Nolen, Sumeet Sodhi
BACKGROUND: Chronic diseases, primarily cardiovascular disease, respiratory disease, diabetes and cancer, are the leading cause of death and disability worldwide. In sub-Saharan Africa (SSA), where communicable disease prevalence still outweighs that of non-communicable disease (NCDs), rates of NCDs are rapidly rising and evidence for primary healthcare approaches for these emerging NCDs is needed. METHODS: A systematic review and evidence synthesis of primary care approaches for chronic disease in SSA...
March 23, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28330388/identifying-synergies-in-multilevel-interventions
#15
Megan A Lewis, Tania M Fitzgerald, Brittany Zulkiewicz, Susana Peinado, Pamela A Williams
Social ecological models of health often describe multiple levels of influence that interact to influence health. However, it is still common for interventions to target only one or two of these levels, perhaps owing in part to a lack of guidance on how to design multilevel interventions to achieve optimal impact. The convergence strategy emphasizes that interventions at different levels mutually reinforce each other by changing patterns of interaction among two or more intervention audiences; this strategy is one approach for combining interventions at different levels to produce synergistic effects...
April 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28329850/the-use-of-growth-mixture-modeling-for-studying-resilience-to-major-life-stressors-in-adulthood-and-old-age-lessons-for-class-size-and-identification-and-model-selection
#16
Frank J Infurna, Kevin J Grimm
Objectives: Growth mixture modeling (GMM) combines latent growth curve and mixture modeling approaches and is typically used to identify discrete trajectories following major life stressors (MLS). However, GMM is often applied to data that does not meet the statistical assumptions of the model (e.g., within-class normality) and researchers often do not test additional model constraints (e.g., homogeneity of variance across classes), which can lead to incorrect conclusions regarding the number and nature of the trajectories...
March 8, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28329821/extracurricular-involvement-in-high-school-and-later-life-participation-in-voluntary-associations
#17
Emily A Greenfield, Sara M Moorman
Objectives: Scholars have identified participation in voluntary associations as a central component of civic engagement for younger and older people alike. However, there has been little longitudinal examination of how such participation potentially fluctuates across multiple periods of the life course, as well as the extent to which involvement in youth is associated with participation in later life. Method: We used data from the Wisconsin Longitudinal Study-which is among the oldest and most comprehensive cohort studies in the United States to date...
January 19, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28328388/bedside-critical-care-staff-use-of-intensive-care-unit-telemedicine-comparisons-by-intensive-care-unit-complexity
#18
Jonathan T Thomas, Jane Moeckli, Michelle A Mengeling, Cassie Cunningham Goedken, Jacinda Bunch, Peter Cram, Heather Schacht Reisinger
BACKGROUND: Effects of Intensive Care Unit (ICU) telemedicine on patient and staff outcomes are mixed. Variation in utilization is potentially driving these differences. INTRODUCTION: ICU telemedicine utilization is understudied, with existing research focusing on telemedicine staff. We assess ICU telemedicine utilization from the perspective of the end user-ICU staff-to better understand how telemedicine use is conceptualized and practiced at the bedside. MATERIALS AND METHODS: We conducted a thematic content analysis of semistructured interviews with bedside ICU staff...
February 16, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28328195/degradation-dynamics-for-electrochromic-wo3-films-under-extended-charge-insertion-extraction-unveiling-physicochemical-mechanisms
#19
Rui-Tao Wen, Sara Malmgren, Claes G Granqvist, Gunnar A Niklasson
Degradation of electrochromic thin films under extended charge insertion/extraction is a technically important phenomenon for which no in-depth understanding is currently at hand. Here we report on an explorative study of sputter-deposited WO3 films in a Li-ion-conducting electrolyte by use of cyclic voltammetry, in situ optical transmittance, and impedance spectroscopy. A cycling-dependent decrease of the charge capacity could be accurately modeled by a power-law function, and impedance spectroscopy gave evidence for anomalous diffusion as well a higher charge transfer resistance during deintercalation than during intercalation...
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28326591/arbitrarily-applicable-spatial-relational-responding
#20
Richard J May, Ian Stewart, Luisa Baez, Gary Freegard, Simon Dymond
Spatial reasoning, where novel spatial relationships are inferred based on trained relationships, can be conceptualized as arbitrarily applicable spatial relational responding. Here, we conducted two experiments to develop and validate, for the first time, a laboratory procedure to establish arbitrarily applicable spatial relational responding in adult humans. In Experiment 1, participants were trained on nonarbitrary spatial relational tasks designed to establish contextual cues for left of, right of, above, and below...
March 2017: Journal of the Experimental Analysis of Behavior
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