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https://www.readbyqxmd.com/read/28230291/therapeutic-potentials-of-bdnf-trkb-in-breast-cancer-current-status-and-perspectives
#1
Amir Tajbakhsh, Amin Mokhtari-Zaer, Mehdi Rezaee, Fahimeh Afzaljavan, Mehdi Rivandi, Seyed Mahdi Hassanian, Gordon A Ferns, Alireza Pasdar, Amir Avan
Brain-derived neurotrophic factor (BDNF) is a potent neurotrophic factor that has been shown to stimulate breast cancer cell growth and metastasis via tyrosine kinase receptors TrkA, TrkB and the p75(NTR) death receptor. The aberrant activation of BDNF/TrkB pathways can modulate several signaling pathways, including Akt/PI3K, Jak/STAT, NF-kB, UPAR/UPA, Wnt/β-catenin and VEGF pathways as well as the ER receptor. Several microRNAs have been identified that are involved in the modulation of BDNF/TrkB pathways...
February 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28228689/athyrium-haleakalae-athyriaceae-a-new-rheophytic-fern-species-from-east-maui-hawaiian-islands-with-notes-on-its-distribution-ecology-and-conservation-status
#2
Kenneth R Wood, Warren L Wagner
Athyrium haleakalae K.R. Wood & W.L. Wagner (Athyriaceae), a small lithophytic fern from East Maui, Hawaiian Islands, is described and illustrated. Notes on its distribution, ecology, and conservation status are also presented. The new species appears to be an obligate rheophyte, preferring sites of fast moving water along concave walls of streams and waterfalls. Athyrium haleakalae differs from the only other known Hawaiian Athyrium, Athyrium microphyllum (Sm.) Alston, in having rhizomes 1-3 cm long and lanceolate blades 1- to 2-pinnate-pinnatifid, 3-8(-11) × 1-3(-4) cm, as compared to Athyrium microphyllum having rhizomes (10-)15-30 cm long and ovate to ovate-triangular blades 3-pinnate-pinnatifid to 4-pinnate, 30-82 × 20-50 cm...
2017: PhytoKeys
https://www.readbyqxmd.com/read/28219417/documenting-research-with-transgender-and-gender%C3%A2-diverse-people-protocol-for-an-evidence-map-and-thematic-analysis
#3
Zack Marshall, Vivian Welch, James Thomas, Fern Brunger, Michelle Swab, Ian Shemilt, Chris Kaposy
BACKGROUND: There is limited information about how transgender, gender diverse, and Two-Spirit (trans) people have been represented and studied by researchers. The objectives of this study are to (1) map and describe trans research in the social sciences, sciences, humanities, health, education, and business, (2) identify evidence gaps and opportunities for more responsible research with trans people, (3) assess the use of text mining for study identification, and (4) increase access to trans research for key stakeholders through the creation of a web-based evidence map...
February 20, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28216880/isolation-and-characterisation-of-a-proanthocyanidin-with-antioxidative-antibacterial-and-anti-cancer-properties-from-fern-blechnum-orientale
#4
How-Yee Lai, Yau-Yan Lim, Kah-Hwi Kim
BACKGROUND: Blechnum orientale Linn. (Blechnaceae), a fern, is traditionally used in the treatment of various ailments, such as skin diseases, stomach pain, urinary bladder complaints, and also as a female contraceptive. Previously, we reported a strong radical scavenging activity, antibacterial activity and cytotoxicity against HT29 colon cancer cells by aqueous extract of B. orientale. OBJECTIVE: In this study, we attempted to isolate and identify the active compound from the aqueous extract of B...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28208028/early-life-wildfire-smoke-exposure-is-associated-with-immune-dysregulation-and-lung-function-decrements-in-adolescence
#5
Carolyn Black, Joan E Gerriets, Justin H Fontaine, Richart W Harper, Nicholas J Kenyon, Fern Tablin, Edward S Schelegle, Lisa A Miller
RATIONALE: The long-term health effects of wildfire smoke exposure in pediatric populations are not known. OBJECTIVE: To determine if early life exposure to wildfire smoke can affect parameters of immunity and airways physiology that are detectable with maturity. METHODS: We studied a mixed gender cohort of rhesus macaque monkeys that were exposed as infants to ambient wood smoke from a series of Northern California wildfires in the summer of 2008...
February 16, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28205656/an-autonomous-lab-on-a-chip-for-space-flight-calibration-of-gravity-induced-transcellular-calcium-polarization-in-single-cell-fern-spores
#6
J Park, M L Salmi, W W A Wan Salim, A Rademacher, B Wickizer, A Schooley, J Benton, A Cantero, P F Argote, M Ren, M Zhang, D M Porterfield, A J Ricco, S J Roux, J L Rickus
This report describes the development of lab-on-a-chip device designed to measure changes in cellular ion gradients that are induced by changes in gravitational (g) forces. The bioCD presented here detects differential calcium ion concentrations outside of individual cells. The device includes sufficient replicates for statistical analysis of the gradients around multiple single cells and around control wells that are empty or include dead cells. In the data presented, the degree of the cellular response correlates with the magnitude of the g-force applied via rotation of the bioCD...
February 16, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28198120/effects-of-curcumin-on-serum-vitamin-e-concentrations-in-individuals-with-metabolic-syndrome
#7
Akram Mohammadi, Hamid Reza Sadeghnia, Maryam Saberi-Karimian, Hamideh Safarian, Gordon A Ferns, Majid Ghayour-Mobarhan, Amirhossein Sahebkar
Vitamin E is an important lipid-soluble antioxidant. The aim of the present study was to investigate the effect of curcumin on serum vitamin E levels in subjects with metabolic syndrome (MetS). A total of 120 subjects aged 18-65 years old with MetS were recruited in this study according to the International Diabetic Federation Criteria. Included subjects were randomized into three groups: subjects receiving lecithinized curcumin (1 g/day equivalent to 200-mg pure curcumin per day) for a period of 6 weeks )n = 40), patients receiving unformulated curcumin (1 g/day) for a period of 6 weeks )n = 40) and a control group receiving placebo for the same period (n = 40)...
February 15, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28192882/ethyl-acetate-fraction-of-pteris-vittata-l-alleviates-2-acetylaminofluorene-induced-hepatic-alterations-in-male-wistar-rats
#8
Paramjeet Kaur, Manish Kumar, Amrit Pal Singh, Satwinderjeet Kaur
Pteris vittata L. commonly called 'Brake Fern' possesses some interesting medicinal properties but its chemopreventive potential largely remains unexplored. Therefore, this study was designed to explore the chemopreventive efficacy of P. vittata L. ethyl acetate fraction (PVEA) against 2-acetylaminofluorene (2-AAF) induced liver toxicity in Wistar rats. Antioxidant activity of PVEA was evaluated using various in vitro antioxidant assays. The protective effects of PVEA were evaluated against 2-acetylaminofluorene (2-AAF) induced hepatic damage in Wistar rats...
February 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28187897/the-application-of-a-decision-tree-to-establish-the-parameters-associated-with-hypertension
#9
Maryam Tayefi, Habibollah Esmaeili, Maryam Saberi Karimian, Alireza Amirabadi Zadeh, Mahmoud Ebrahimi, Mohammad Safarian, Mohsen Nematy, Seyed Mohammad Reza Parizadeh, Gordon A Ferns, Majid Ghayour-Mobarhan
INTRODUCTION: Hypertension is an important risk factor for cardiovascular disease (CVD). The goal of this study was to establish the factors associated with hypertension by using a decision-tree algorithm as a supervised classification method of data mining. METHODS: Data from a cross-sectional study were used in this study. A total of 9078 subjects who met the inclusion criteria were recruited. 70% of these subjects (6358 cases) were randomly allocated to the training dataset for the constructing of the decision-tree...
February 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28176634/targeting-the-akt-pi3k-signaling-pathway-as-a-potential-therapeutic-strategy-for-the-treatment-of-pancreatic-cancer
#10
Safieh Ebrahimi, Mina Hosseini, Soodabeh Shahidsales, Mina Maftouh, Gordon A Ferns, Majid Ghayour-Mobarhan, Seyed Mahdi Hassanian, Amir Avan
The phosphoinositide 3 kinase AKT mammalian target of rapamycin (PI3K-AKT-mTOR) signaling pathway is an important signaling pathway in pancreatic cancer (PC). It is frequently activated in PC and is associated with worse outcome. Aberrant activation of this pathway is involved in cell metabolism and survival, cell cycle progression, regulation of apoptosis, protein synthesis, and genomic instability. Several agents have been developed to target Akt/PI3K pathways, including PI3K inhibitors, (e.g. LY294002, Wortmannin), PI3K/mTOR inhibitors (e...
February 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28164511/application-of-six-sigma-model-to-evaluate-the-analytical-quality-of-four-hba1c-analyzers
#11
Jos Eacute M Maesa, Patricia Fern Aacute Ndez-Riejos, Catalina S Aacute Nchez-Mora, Mar Iacute A De Toro-Crespo, Concepci Oacute N Gonz Aacute Lez-Rodriguez
BACKGROUND: The Six Sigma Model is a global quality management system applicable to the determination of glycated hemoglobin (HbA1c). In addition, this model can ensure the three characteristics influencing the patient risk: the correct performance of the analytical method with low inaccuracy and bias, the quality control strategy used by the laboratory, and the necessary quality of the analyte. The aim of this study is to use the Six Sigma Model for evaluating quality criteria in the determination of glycated hemoglobin HbA1c and its application to assess four different HbA1c analyzers...
January 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28164337/evaluating-the-spore-genome-sizes-of-ferns-and-lycophytes-a-flow-cytometry-approach
#12
Li-Yaung Kuo, Yi-Jia Huang, JenYu Chang, Wen-Liang Chiou, Yao-Moan Huang
Ferns and lycophytes produce spores to initiate the gametophyte stage for sexual reproduction. Approximately 10% of these seedless vascular plants are apomictic, and produce genomic unreduced spores. Genome size comparisons between spores and leaves are a reliable, and potentially easier way to determine their reproductive mode compared to traditional approaches. However, estimation of the spore genome sizes of these plants has not been attempted. We attempted to evaluate the spore genome sizes of ferns and lycophytes using flow cytometry, collected spores from selected species representing different spore physical properties and taxonomic groups, and sought to optimize bead-vortexing conditions...
March 2017: New Phytologist
https://www.readbyqxmd.com/read/28152418/variation-of-desiccation-tolerance-and-longevity-in-fern-spores
#13
Daniel Ballesteros, Lisa M Hill, Christina Walters
This work contributes to the understanding of plant cell responses to extreme water stress when it is applied at different intensity and duration. Fern spores are used to explore survival at relative humidity (RH)<85% because their unicellular nature eliminates complexities that may arise in multicellular organisms from slower drying and variable responses of different cell types. Fern spore cytoplasm solidifies between 30 and 60% RH and spores survive this transition, but subsequently lose viability. We characterized the kinetics of viability loss in terms of the fluid to solid transition using concepts of water activity (i...
January 15, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28130914/enhancement-of-dielectrophoresis-using-fractal-gold-nanostructured-electrodes
#14
Anil Koklu, Ahmet C Sabuncu, Ali Beskok
Dielectrophoretic motions of Saccharomyces Cerevisiae (yeast) cells and colloidal gold are investigated using electrochemically modified electrodes exhibiting fractal topology. Electrodeposition of gold on electrodes generated repeated patterns with a fern-leaf type self-similarity. A particle tracking algorithm is used to extract dielectrophoretic particle velocities using fractal and planar electrodes in two different medium conductivities. The results show increased dielectrophoretic force when using fractal electrodes...
January 28, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28121463/prevalence-of-acute-onset-subtypes-in-pediatric-obsessive-compulsive-disorder
#15
Fern Jaspers-Fayer, Sang Hun Jerry Han, Elaine Chan, Katherine McKenney, Annie Simpson, Andrea Boyle, Rhonda Ellwyn, S Evelyn Stewart
BACKGROUND: Pediatric obsessive-compulsive disorder (OCD) is a common, debilitating illness. When childhood OCD symptom onset is described as acute and severe, diagnostic criteria for pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS) should be considered. However, the frequency and differentiating features of these putative syndromes within pediatric OCD remain poorly understood...
January 25, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28118110/heat-exposure-in-central-florida-fernery-workers-results-of-a-feasibility-study
#16
Valerie Vi Thien Mac, Jose Antonio Tovar-Aguilar, Joan Flocks, Jeannie Economos, Vicki Hertzberg, Linda A McCauley
OBJECTIVE: The objective of this study was to determine the feasibility of field-based biomonitoring of heat-related illness (HRI) phenomena in Florida farmworkers. We determined feasibility through participant interviews regarding acceptability, data capture, recruitment and retention, and observed barriers and challenges to implementation. METHODS: Study participants were employed in fernery operations in northeast Central Florida where ornamental ferns are grown and harvested in a seasonally high heat environment...
January 24, 2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28108158/evolutionary-plasticity-of-plasma-membrane-interaction-in-drepp-family-proteins
#17
Stanislav Vosolsobě, Jan Petrášek, Kateřina Schwarzerová
The plant-specific DREPP protein family comprises proteins that were shown to regulate the actin and microtubular cytoskeleton in a calcium-dependent manner. Our phylogenetic analysis showed that DREPPs first appeared in ferns and that DREPPs have a rapid and plastic evolutionary history in plants. Arabidopsis DREPP paralogues called AtMDP25/PCaP1 and AtMAP18/PCaP2 are N-myristoylated, which has been reported as a key factor in plasma membrane localization. Here we show that N-myristoylation is neither conserved nor ancestral for the DREPP family...
January 17, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28105697/association-of-hematocrit-with-blood-pressure-and-hypertension
#18
Marzieh Emamian, Seyed Mahdi Hasanian, Maryam Tayefi, Moniba Bijari, Faeze Movahedian Far, Mojtaba Shafiee, Amir Avan, Alireza Heidari-Bakavoli, Mohsen Moohebati, Mahmoud Ebrahimi, Sousan Darroudi, Parvin Zamani, Mahmoud Reza Azarpazhooh, Mohsen Nematy, Mohammad Safarian, Gordon A Ferns, Habibollah Esmaeili, Mohammad Reza Parizadeh, Majid Ghayour-Mobarhan
BACKGROUND: Hypertension (HTN) is a risk factor for stroke, renal failure, and cardiovascular disease. The association between biochemical and hematological parameters with high blood pressure may provide a more precise approach to risk prediction conferred by HTN in these patients. OBJECTIVE: The aim of current study was to explore whether biochemical and hematological parameters are associated with HTN in a cohort study with a 7-year follow-up. MATERIALS AND METHODS: A total of 9808 individuals were enrolled and recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study, and biochemical and hematological factors were measured in all subjects...
January 20, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28103189/dynamic-programming-for-instance-annotation-in-multi-instance-multi-label-learning
#19
Anh Pham, Raviv Raich, Xiaoli Fern
Labeling data for classification requires significant human effort. To reduce labeling cost, instead of labeling every instance, a group of instances (bag) is labeled by a single bag label. Computer algorithms are then used to infer the label for each instance in a bag, a process referred to as instance annotation. This task is challenging due to the ambiguity regarding the instance labels. We propose a discriminative probabilistic model for the instance annotation problem and introduce an expectation maximization framework for inference, based on the maximum likelihood approach...
January 5, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28102682/identification-of-serratane-synthase-gene-from-the-fern-lycopodium-clavatum
#20
Yusuke Saga, Takeshi Araki, Hiroshi Araya, Kazuki Saito, Mami Yamazaki, Hideyuki Suzuki, Tetsuo Kushiro
Ferns are known to produce onoceroids including onoceranes and serratanes having unusual structures among triterpenes. From the fern Lycopodium clavatum, a novel onoceroid synthase gene was cloned that showed high sequence identity with a previously identified α-onocerin synthase. Functional analysis by coexpression with pre-α-onocerin synthase in yeast led to the production of tohogenol and serratenediol. The result suggested that serratanes are directly biosynthesized from pre-α-onocerin and not from α-onocerin as previously assumed...
January 19, 2017: Organic Letters
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