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https://www.readbyqxmd.com/read/28890935/ski-178-a-multitargeted-inhibitor-of-sphingosine-kinase-and-microtubule-dynamics-demonstrating-therapeutic-efficacy-in-acute-myeloid-leukemia-models
#1
Jeremy A Hengst, Taryn E Dick, Arati Sharma, Kenichiro Doi, Shailaja Hegde, Su-Fern Tan, Laura M Geffert, Todd E Fox, Arun K Sharma, Dhimant Desai, Shantu Amin, Mark Kester, Thomas P Loughran, Robert F Paulson, David F Claxton, Hong-Gang Wang, Jong K Yun
AIM: To further characterize the selectivity, mechanism-of-action and therapeutic efficacy of the novel small molecule inhibitor, SKI-178. METHODS: Using the state-of-the-art Cellular Thermal Shift Assay (CETSA) technique to detect "direct target engagement" of proteins intact cells, in vitro and in vivo assays, pharmacological assays and multiple mouse models of acute myeloid leukemia (AML). RESULTS: Herein, we demonstrate that SKI-178 directly target engages both Sphingosine Kinase 1 and 2...
July 2017: Cancer Translational Medicine
https://www.readbyqxmd.com/read/28882065/annals-express-serum-high-sensitive-c-reactive-protein-is-associated-with-dietary-intakes-in-diabetic-patients-with-and-without-hypertension-a-cross-sectional-study
#2
Mohammad Bagherniya, Sayyed Saeid Khayyatzadeh, Ali Reza Heidari-Bakavoli, Gordon Ferns, Mahmoud Ebrahimi, Mohammad Safarian, Mohsen Nematy, Majid Ghayour-Mobarhan
BACKGROUND: Serum high sensitive C-reactive protein (hs-CRP) concentrations independently predict the development of diabetes, metabolic syndrome and cardiovascular disease. However, the impact of dietary factors on serum hs-CRP concentrations in diabetic patients has received limited attention. We aimed to investigate the association between dietary factors and hs-CRP, among diabetic patients with and without hypertension and healthy subjects. METHODS: In this cross-sectional study, diabetics with (n=325) and without hypertension (n=599) and healthy individuals (n=1220) were recruited in Mashhad, Iran...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28876315/recurrence-of-human-papillomavirus-external-genital-wart-infection-among-high-risk-adults-in-montr%C3%A3-al-canada
#3
Réjean Thomas, Marc Steben, Zoë Greenwald, Melissa Stutz, Caroline Rodier, Fern DeAngelis, Emmanouil Rampakakis
OBJECTIVES: The incidence of recurrent genital warts is not well characterized; this is especially true in a post-human papillomavirus (HPV) vaccination era. The objectives of this study were to assess the incidence of subsequent HPV-related external genital warts (EGW) episodes in high-risk male and female adults, as well as ascertain patient profile and disease characteristics, in a real-world Canadian sexual health clinical setting. METHODS: Retrospective chart review study conducted at Clinique médicale l'Actuel, a sexual health clinic in Montréal, Québec, Canada...
June 20, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28875843/dihydroresveratrol-type-dihydrostilbenoids-chemical-diversity-chemosystematics-and-bioactivity
#4
Sara Vitalini, Serhat Sezai Cicek, Sebastian Granica, Christian Zidorn
Dihydrostilbenoids are a chemically diverse class of secondary metabolites and differ from stilbenoids by the missing double bond in the ethylene chain linking the two aromatic moieties. Dihydrostilbenoids have been reported from flowering plants, fungi, mosses, and ferns. In this review, the occurrence, chemical structure, and bioactivity of 142 naturally occurring dihydrostilbenoids of the dihydroresveratrol type, compounds featuring hydroxy or substituted hydroxy groups at least in positions 3, 5, and 4', will be discussed...
August 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28875104/air-water-interface-of-submerged-superhydrophobic-surfaces-imaged-by-atomic-force-microscopy
#5
Markus Moosmann, Thomas Schimmel, Wilhelm Barthlott, Matthias Mail
Underwater air retention of superhydrophobic hierarchically structured surfaces is of increasing interest for technical applications. Persistent air layers (the Salvinia effect) are known from biological species, for example, the floating fern Salvinia or the backswimmer Notonecta. The use of this concept opens up new possibilities for biomimetic technical applications in the fields of drag reduction, antifouling, anticorrosion and under water sensing. Current knowledge regarding the shape of the air-water interface is insufficient, although it plays a crucial role with regards to stability in terms of diffusion and dynamic conditions...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28863752/divergent-preferences-for-hiv-prevention-a-discrete-choice-experiment-for-multipurpose-hiv-prevention-products-in-south-africa
#6
Matthew Quaife, Robyn Eakle, Maria A Cabrera Escobar, Peter Vickerman, Maggie Kilbourne-Brook, Mercy Mvundura, Sinead Delany-Moretlwe, Fern Terris-Prestholt
BACKGROUND: The development of antiretroviral (ARV)-based prevention products has the potential to substantially change the HIV prevention landscape; yet, little is known about how appealing these products will be outside of clinical trials, as compared with the existing options. METHODS: We conducted a discrete choice experiment (DCE) to measure preferences for 5 new products among 4 important populations in the HIV response: adult men and women in the general population (aged 18 to 49 y), adolescent girls (aged 16 to 17 y), and self-identifying female sex workers (aged 18 to 49 y)...
September 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28862490/phytoextraction-potential-of-water-fern-azolla-pinnata-in-the-removal-of-a-hazardous-dye-methyl-violet-2b-artificial-neural-network-modelling
#7
Muhammad Raziq Rahimi Kooh, Linda B L Lim, Lee Hoon Lim, Owais Ahmed Malik
This study investigated the potential of Azolla pinnata (AP) in the removal of toxic methyl violet 2B (MV) dye wastewater using the phytoextraction approach with the inclusion of an Artificial Neural Network (ANN) modelling. Parameters examined included the effects of dye concentration, pH and plant dosage. The highest removal efficiency was 93% which was achieved at a plant dosage of 0.8 g (dye volume = 200 mL, initial pH = 6.0, initial dye concentration = 10 mg L(-1)). A significant decrease in relative frond number (RFN), a growth rate estimator, observed at a dye concentration of 20 mg L(-1) MV indicated some toxicity, which coincided with the plant pigments studies where the chlorophyll a content was lower than the control...
September 1, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28854625/plastid-phylogenomics-resolve-deep-relationships-among-eupolypod-ii-ferns-with-rapid-radiation-and-rate-heterogeneity
#8
Ran Wei, Yue-Hong Yan, A J Harris, Jong-Soo Kang, Hui Shen, Qiao-Ping Xiang, Xian-Chun Zhang
The eupolypods II ferns represent a classic case of evolutionary radiation and, simultaneously, exhibit high substitution rate heterogeneity. These factors have been proposed to contribute to the contentious resolutions among clades within this fern group in multilocus phylogenetic studies. We investigated the deep phylogenetic relationships of eupolypod II ferns by sampling all major families and using 40 plastid genomes, or plastomes, of which 33 were newly sequenced with next-generation sequencing technology...
June 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28852804/prolonged-exposure-of-mouse-and-human-podocytes-to-insulin-induces-insulin-resistance-through-lysosomal-and-proteasomal-degradation-of-the-insulin-receptor
#9
Abigail C Lay, Jenny A Hurcombe, Virginie M S Betin, Fern Barrington, Ruth Rollason, Lan Ni, Lawrence Gillam, Grace M E Pearson, Mette V Østergaard, Hellyeh Hamidi, Rachel Lennon, Gavin I Welsh, Richard J M Coward
AIMS/HYPOTHESIS: Podocytes are insulin-responsive cells of the glomerular filtration barrier and are key in preventing albuminuria, a hallmark feature of diabetic nephropathy. While there is evidence that a loss of insulin signalling to podocytes is detrimental, the molecular mechanisms underpinning the development of podocyte insulin resistance in diabetes remain unclear. Thus, we aimed to further investigate podocyte insulin responses early in the context of diabetic nephropathy. METHODS: Conditionally immortalised human and mouse podocyte cell lines and glomeruli isolated from db/db DBA/2J mice were studied...
August 29, 2017: Diabetologia
https://www.readbyqxmd.com/read/28841357/abscisic-acid-aba-and-key-proteins-in-its-perception-and-signalling-pathways-are-ancient-but-their-roles-have-changed-through-time
#10
Frances C Sussmilch, Nadia M Atallah, Timothy J Brodribb, Jo Ann Banks, Scott A M McAdam
Homologs of the Arabidopsis core abscisic acid (ABA) signalling component OPEN STOMATA1 (OST1) are best known for their role in closing stomata in angiosperm species. We recently characterised a fern OST1 homolog, GAMETOPHYTES ABA INSENSITIVE ON ANTHERDIOGEN 1 (GAIA1), which is not required for stomatal closure in ferns, consistent with physiological evidence that shows the stomata of these plants respond passively to changes in leaf water status. Instead, gaia1 mutants reveal a critical role in ABA signalling for spore dormancy and sex determination, in a system regulated by antagonism between ABA and the gibberellin (GA)-derived fern hormone antheridiogen (ACE)...
August 25, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28840615/the-effects-of-curcumin-and-curcumin-phospholipid-complex-on-the-serum-pro-oxidant-antioxidant-balance-in-subjects-with-metabolic-syndrome
#11
Maryam Ghazimoradi, Maryam Saberi-Karimian, Farzane Mohammadi, Amirhossein Sahebkar, Shima Tavallaie, Hamideh Safarian, Gordon A Ferns, Majid Ghayour-Mobarhan, Mohsen Moohebati, Habibollah Esmaeili, Malihe Ahmadinejad
Metabolic syndrome (MetS) is defined by a clustering of metabolic and anthropometric abnormalities and is associated by an increased risk of cardiovascular disease. We have investigated the effect of curcumin supplementation on the serum pro-oxidant-antioxidant balance (PAB) in patients with MetS. This double-blind, randomized, placebo-controlled trial was conducted over 6 weeks. Subjects (n = 120) were randomly allocated to one of three groups (curcumin, phospholipidated curcumin, and placebo). The curcumin group received 1 g/day of simple curcumin, the phospholipidated curcumin group received 1 g/day of phospholipidated curcumin (containing 200 mg of pure curcumin), and the control group received 1 g/day of placebo...
August 25, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28837409/use-of-a-gc-ms-organic-aerosol-monitor-for-in-field-detection-of-fine-particulate-organic-compounds-in-source-apportionment
#12
Paul M Cropper, Delbert J Eatough, Devon K Overson, Jaron C Hansen, Fern Caka, Robert A Cary
A study was conducted on the Brigham Young University campus during January and February 2015 to identify winter-time sources of fine particulate material in Utah Valley, Utah. Fine particulate mass and components and related gas phase species were all measured on an hourly average basis. Light scattering was also measured during the study. Included in the sampling was the first-time source apportionment application of a new monitoring instrument for the measurement of fine particulate organic marker compounds on an hourly average basis...
August 24, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28835265/conservation-and-divergence-of-small-rna-pathways-and-micrornas-in-land-plants
#13
Chenjiang You, Jie Cui, Hui Wang, Xinping Qi, Li-Yaung Kuo, Hong Ma, Lei Gao, Beixin Mo, Xuemei Chen
BACKGROUND: As key regulators of gene expression in eukaryotes, small RNAs have been characterized in many seed plants, and pathways for their biogenesis, degradation, and action have been defined in model angiosperms. However, both small RNAs themselves and small RNA pathways are not well characterized in other land plants such as lycophytes and ferns, preventing a comprehensive evolutionary perspective on small RNAs in land plants. RESULTS: Using 25 representatives from major lineages of lycophytes and ferns, most of which lack sequenced genomes, we characterized small RNAs and small RNA pathways in these plants...
August 23, 2017: Genome Biology
https://www.readbyqxmd.com/read/28833502/tumor-derived-exosomes-potential-biomarker-or-therapeutic-target-in-breast-cancer
#14
AmirReza Hesari, Seyed Ali Golrokh Moghadam, AmirShayan Siasi, Mahsa Rahmani, Negin Behboodi, Azam Rastgar-Moghadam, Gordon A Ferns, Faezeh Ghasemi, Amir Avan
Exosomes are released by normal and tumour cells, including those involved in breast cancer, and provide a means of intercellular communications. Exosomes with diameters ranging between 30-150 nm are involved in transferring biological information, via various lipids, proteins, different forms of RNAs, and DNA from one cell to another, and this can result in reprogramming of recipient cell functions. These vesicles are present in all body fluids, e.g., blood plasma/serum, semen, saliva, cerebrospinal fluid, breast milk, and urine...
August 18, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28814626/are-there-long-term-consequences-of-room-sharing-during-infancy
#15
Rachel Y Moon, Fern R Hauck
No abstract text is available yet for this article.
June 5, 2017: Pediatrics
https://www.readbyqxmd.com/read/28814602/carbon-nanoparticles-inhibit-the-antimicrobial-activities-of-the-human-cathelicidin-ll-37-through-structural-alteration
#16
Fern Findlay, Jan Pohl, Pavel Svoboda, Priyanka Shakamuri, Kevin McLean, Neil F Inglis, Lorna Proudfoot, Peter G Barlow
Host defense peptides, also known as antimicrobial peptides, are key elements of innate host defense. One host defense peptide with well-characterized antimicrobial activity is the human cathelicidin, LL-37. LL-37 has been shown to be upregulated at sites of infection and inflammation and is regarded as one of the primary innate defense molecules against bacterial and viral infection. Human exposure to combustion-derived or engineered nanoparticles is of increasing concern, and the implications of nanomaterial exposure on the human immune response is poorly understood...
August 16, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28814407/fungal-endophyte-communities-in-the-temperate-fern-polystichum-munitum-show-early-colonization-and-extensive-temporal-turnover
#17
Brett S Younginger, Daniel J Ballhorn
PREMISE OF THE STUDY: Fungal endophytes have been shown to colonize all land plants, yet surprisingly little attention has been given to their community composition in ferns. We examined the diversity and temporal turnover of fungal endophytes in foliar tissue of the temperate western sword fern, Polystichum munitum, comparing taxa in newly emerged leaflets and in the same fronds after 1 mo of exposure in the field. METHODS: Utilizing next-generation sequencing, we sampled pinnae from P...
August 16, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28814405/can-asexuality-confer-a-short-term-advantage-investigating-apparent-biogeographic-success-in-the-apomictic-triploid-fern-myriopteris-gracilis
#18
David A Wickell, Michael D Windham, Xiaofei Wang, Stuart J Macdonald, James B Beck
PREMISE OF THE STUDY: Although asexual taxa are generally seen as evolutionary dead ends, asexuality appears to provide a short-term benefit in some taxa, including a wider geographic distribution compared to sexual relatives. However, this may be an illusion created by multiple, morphologically cryptic, asexual lineages, each occupying a relatively small area. In this study we investigate the role of multiple lineages in the biogeography of Myriopteris gracilis Fée (Pteridaceae), a North American apomictic triploid fern species with a particularly large range...
August 16, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28808402/role-of-adiantum-philippense-l-on-glucose-uptake-in-isolated-pancreatic-cells-and-inhibition-of-adipocyte-differentiation-in-3t3-l1-cell-line
#19
Tania Paul, Kishori G Apte, Pradeep B Parab, Biswadeep Das
BACKGROUND: Adiantum philippense (AP) is a pteridophyte that shows antihyperglycemic activity in vivo diabetic model, but the mechanism of action is unknown. OBJECTIVE: AP was found to play a pivotal role in minimizing the high blood glucose in alloxan-induced diabetic rats. Simultaneously, it was observed that it could maintain the normal lipid profile even in diabetic condition. To investigate its insulin-like activity along with its inhibitory role on adipocyte differentiation became the objective of our present study...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28806464/beyond-back-to-sleep-ways-to-further-reduce-the-risk-of-sudden-infant-death-syndrome
#20
Fern R Hauck, Kawai O Tanabe
Sudden infant death syndrome (SIDS) remains the leading cause of postneonatal mortality in the United States, despite reduction in rates of more than 50% since the initiation of the "Back to Sleep" (now called "Safe to Sleep") campaign in 1994. In recent years, the rate of decline in SIDS deaths has plateaued, even with the ongoing educational efforts that promote safe sleep and other risk reduction measures. The 2016 American Academy of Pediatrics guidelines for reducing the risk of SIDS focus heavily on sleep practices, bedding, and location, but also include factors that often receive less attention (ie, prenatal care, maternal smoking, alcohol and drug use, and childhood vaccinations)...
August 1, 2017: Pediatric Annals
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