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https://www.readbyqxmd.com/read/29160150/electrocardiogram-screening-in-children-with-congenital-sensorineural-hearing-loss-prevalence-and-follow-up-of-abnormalities
#1
Zainab Farzal, Jonathan Walsh, Faisal I Ahmad, Jason Roberts, Sunita J Ferns, And Carlton J Zdanski
Objective The purpose is to determine the prevalence of electrocardiogram (ECG) abnormalities, including borderline and prolonged QT, among screened children with sensorineural hearing loss (SNHL) and to analyze their subsequent medical workup. Study Design Institutional Review Board-approved case series with chart review. Setting Tertiary academic center. Subjects and Methods Cases from 1996 to 2014 involving pediatric patients (N = 1994) with SNHL were analyzed. Abnormal ECGs were categorized as borderline/prolonged QT or other...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29159691/potential-treatment-of-atopic-dermatitis-tolerability-and-safety-of-cream-containing-nanoparticles-loaded-with-hydrocortisone-and-hydroxytyrosol-in-human-subjects
#2
Muhammad Irfan Siddique, Haliza Katas, Adawiyah Jamil, Mohd Cairul Iqbal Mohd Amin, Shiow-Fern Ng, Mohd Hanif Zulfakar, Syed Maaz Nadeem
Hydrocortisone (HC), topical glucocorticoid along with hydroxytyrosol (HT), and anti-microbial- and anti-oxidant-loaded chitosan nanoparticles (CSNPs) were prepared in large scale and analyzed for their adverse effects on healthy human skin followed by repeated applications. Ten subjects were randomized to receive test (HC-HT CSNPs) and vehicle samples (aqueous (AQ) cream). They were applied on the arms for 28 days, and transepidermal water loss (TEWL), erythema intensity, and irritation score were measured...
November 20, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29155694/paracentral-acute-middle-maculopathy-in-primary-congenital-glaucoma
#3
Yavuz K Aribas, Zeynep Aktas, Kemal Bayrakceken, Tuba Atalay, Sengul Ozdek
PURPOSE: To report a case of primary congenital glaucoma associated with paracentral acute middle maculopathy. METHODS: A case report. RESULTS: A 14-year-old girl with undiagnosed primary congenital glaucoma was referred for the evaluation of sudden vision loss a week after the initial symptoms. Visual acuity was counting fingers at 2 m in the right eye. Examination of her right eye revealed corneal stromal scar like Haab striae, splinter hemorrhage at the temporal border of the optic disk, perivenular hemorrhage, and fern-like white area at the macula...
November 16, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29150944/toll-like-receptor-signaling-pathway-as-a-potential-therapeutic-target-in-colorectal-cancer
#4
REVIEW
Reyhaneh Moradi-Marjaneh, Seyed Mahdi Hassanian, Hamid Fiuji, Saman Soleimanpour, Gordon A Ferns, Amir Avan, Majid Khazaei
Toll like receptor (TLR) signaling is involved in activating innate and adaptive immune responses and plays a critical role in inflammation-induced diseases such as colorectal cancer (CRC). Dysregulation of this signaling pathway can result in disturbance of epithelial layer hemostasis, chronic inflammatory, excessive repair responses and development of CRC. There is now substantial evidence for the benefit of targeting of this pathway in cancer treatment, and several agents have been approved, such as BCG (Bacillus Calmette Guérin), MPL (monophosphoryl lipid A) and imiquimod...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29150934/the-current-status-and-perspectives-regarding-the-clinical-implication-of-intracellular-calcium-in-breast-cancer
#5
REVIEW
Amir Tajbakhsh, Alireza Pasdar, Mehdi Rezaee, Mostafa Fazeli, Saman Soleimanpour, Seyed Mahdi Hassanian, Zahra FarshchiyanYazdi, Tayebe Younesi Rad, Gordon A Ferns, Amir Avan
Calcium ions (Ca(2+) ) act as second messengers in intracellular signaling. Ca(2+) pumps, channels, sensors, and calcium binding proteins, regulate the concentrations of intracellular Ca(2+) as a key regulator of important cellular processes such as gene expression, proliferation, differentiation, DNA repair, apoptosis, metastasis, and hormone secretion. Intracellular Ca(2+) also influences the functions of several organelles, that include: the endoplasmic reticulum, mitochondria, the Golgi, and cell membrane both in normal and breast cancer cells...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29145089/arsenic-removal-from-as-hyperaccumulator-pteris-vittata-biomass-coupling-extraction-with-precipitation
#6
Evandro B da Silva, Letuzia M de Oliveira, Ann C Wilkie, Yungen Liu, Lena Q Ma
Proper disposal of As-hyperaccumulator Pteris vittata biomass (Chinese brake fern) enhances its application in phytoremediation. The goal of this study was to optimize As removal from P. vittata (PV) biomass by testing different particle sizes, extractants, extraction times and solid-to-liquid ratios. PV biomass was extracted using different extractants followed by different Mg-salts to recover soluble As via precipitation. Water-soluble As in PV biomass varied from 6.8% to 61% of total As depending on extraction time, with 99% of As being arsenate (AsV)...
October 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/29142250/loss-of-lamin-b1-is-a-biomarker-to-quantify-cellular-senescence-in-photoaged-skin
#7
Audrey Shimei Wang, Peh Fern Ong, Alexandre Chojnowski, Carlos Clavel, Oliver Dreesen
Skin ageing is an inevitable consequence of life and accelerated by exposure to ultraviolet (UV) rays. Senescence is an irreversible growth arrest and senescent cells accumulate in ageing tissues, at sites of age-related pathologies and in pre-neoplastic lesions. Conventionally, senescent cells have been detected by senescence associated-β-galactosidase (SA-β-gal) staining, a procedure that requires enzymatic activity, which is lost in fixed tissue samples. We previously demonstrated that loss of lamin B1 is a novel marker to identify senescent cells...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29136622/serum-transaminase-concentrations-and-the-presence-of-irritable-bowel-syndrome-are-associated-with-serum-25-hydroxy-vitamin-d-concentrations-in-adolescent-girls-who-are-overweight-and-obese
#8
Sayyed Saeid Khayyatzadeh, Hassanali Vatanparast, Amir Avan, Mohammad Bagherniya, Afsane Bahrami, Mohammad Ali Kiani, Hamidreza Bahrami-Taghanaki, Gordon A Ferns, Majid Ghayour-Mobarhan
BACKGROUND/AIMS: Vitamin D deficiency has become endemic globally and its etiology is complex. Few studies have investigated the determinants of serum 25-hydroxy vitamin D (25-OH D). The aim of this study was to investigate the association between lifestyle patterns, liver functional tests (LFTs), and the presence of irritable bowel syndrome (IBS) with serum 25-OH D in apparently healthy girls. METHODS: This cross-sectional study was undertaken in 965 adolescent girls aged 12-18 years...
November 14, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29134976/uptake-of-zinc-by-pteridium-aquilinum-bracken-fern-and-response-of-clarias-gariepinus-juveniles-during-chronic-and-sub-lethal-exposure
#9
F E Olaifa, A A Fabusoro
Zinc is an essential trace element but can be toxic to fish at elevated concentrations. This study was carried out to assess the uptake of zinc by Clarias gariepinus juveniles and Pteridium aquilinum during chronic exposure to sub lethal concentrations. Two experiments were undertaken simultaneously in static renewal bioassays for 28 days.Haematology, histology, zinc accumulation in tissues of C.gariepinus and P. aquilinum were recorded fortnightly. Packed Cell Volume, haemoglobin concentration, Red Blood Cells, White blood cells, Lymphocytes, Neutrophils, Mean Corpuscular Volume, Mean Corpuscular Haemoglobin Concentration and Mean Corpuscular Haemoglobin of C...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29131473/production-of-hydroxynitrile-lyase-from-d-tyermanii-dthnl-in-komagataella-phaffii-and-its-immobilization-as-clea-to-generate-a-robust-biocatalyst
#10
Elisa Lanfranchi, Birgit Grill, Zainab Raghoebar, Sander van Pelt, Roger Sheldon, Kerstin Steiner, Anton Glieder, Margit Winkler
Hydroxynitrile lyase from the white rabbit's foot fern Davallia tyermanii (DtHNL) catalyzes the enantioselective synthesis of α-cyanohydrins, key building blocks for pharmaceutical and agrochemical industries. An efficient and competitive process necessitates the availability and robustness of the biocatalyst. Herein, the recombinant production of DtHNL1 in Komagataella phaffii is described, yielding approximately 900,000 U/L. DtHNL1 constitutes approximately 80% of the total protein content. The crude enzyme was immobilized...
November 13, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29129225/lipopolysaccharide-induced-neutrophil-extracellular-trap-formation-in-canine-neutrophils-is-dependent-on-histone-h3-citrullination-by-peptidylarginine-deiminase
#11
Ronald H L Li, Geena Ng, Fern Tablin
Neutrophils release neutrophil extracellular traps (NETs), which are extracellular chromatin decorated with histones and antimicrobial proteins. Although known for antimicrobial properties, overzealous production of NETs (NETosis) may lead to cytotoxicity and multiple organ failure in sepsis. Pathogen-induced NETosis has been extensively studied in mice but its importance in dogs remains largely unknown. This study sought to characterize in vitro NETosis induced by E.coli LPS, including assessing the role of peptidylarginine deiminase (PAD) in canine NETosis...
December 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29128340/the-interaction-between-a-hsp-70-gene-variant-with-dietary-calories-in-determining-serum-markers-of-inflammation-and-cardiovascular-risk
#12
Mehrane Mehramiz, Seyed Mahdi Hassanian, Maryam Mardan-Nik, Alireza Pasdar, Khadijeh Jamialahmadi, Hamid Fiuji, Mehrdad Moetamani-Ahmadi, Seyed Mohammad Reza Parizadeh, Mohsen Moohebati, Alireza Heidari-Bakavoli, Mahmoud Ebrahimi, Gordon A Ferns, Majid Ghayour-Mobarhan, Amir Avan
BACKGROUND: The high prevalence of cardiovascular disease (CVD) globally is attributable to an interaction between environmental and genetic factors. Gene × diet interaction studies aim to explore how a modifiable factor interacts with genetic predispositions. Here we have explored the interaction of a heat shock protein (HSP70) gene polymorphism (+1267A > G) with dietary intake and their possible association with serum C-reactive protein (CRP), an inflammatory marker, that is a major component of CVD risk...
October 24, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29127802/resistance-mechanisms-and-their-difference-between-the-root-and-leaf-of-microsorum-pteropus-a-novel-potential-aquatic-cadmium-hyperaccumulator
#13
Xin-Yu Lan, Bin Yang, Yun-Yun Yan, Xin-Yuan Li, Fu-Liu Xu
Microsorum pteropus (M. pteropus), an aquatic Polypodiaceae fern, was identified as a novel potential cadmium (Cd) hyperaccumulator in our previous study. This study reveals the Cd-resistance mechanisms and their difference between the root and leaf of M. pteropus based on analyses of photosynthesis, antioxidant systems and gene expression. A high level of Cd at 500μM was used to treat the samples to test the effects of this compound. Superoxide dismutase (SOD), peroxidase (POD), malondialdehyde (MDA) and flavonoids were used as indicators for antioxidant system changes...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29122799/qualitative-study-to-understand-the-barriers-to-recruiting-young-people-with-cancer-to-brightlight-a-national-cohort-study-in-england
#14
Charlotte Kenten, Ana Martins, Lorna A Fern, Faith Gibson, Sarah Lea, Nothando Ngwenya, Jeremy S Whelan, Rachel M Taylor
OBJECTIVES: BRIGHTLIGHT is a national evaluation of cancer services for teenagers and young adults in England. Following challenges with recruitment, our aim was to understand more fully healthcare professionals' perspectives of the challenges of recruiting young people to a low-risk observational study, and to provide guidance for future recruitment processes. DESIGN: Qualitative. SETTING: National Health Service (NHS) hospitals in England...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29121548/point-of-care-viscoelastic-testing-improves-the-outcome-of-pregnancies-complicated-by-severe-postpartum-hemorrhage
#15
Denis Snegovskikh, Dmitri Souza, Zachary Walton, Feng Dai, Rachel Rachler, Angelique Garay, Victoria V Snegovskikh, Ferne R Braveman, Errol R Norwitz
No abstract text is available yet for this article.
November 6, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29118952/24-hour-survival-after-cardiopulmonary-resuscitation-is-reduced-in-patients-with-diabetes-mellitus
#16
Ali Movahedi, Seyed Reza Mirhafez, Hamidreza Behnam-Voshani, Hamidreza Reihani, Gordon A Ferns, Javad Malekzadeh
Introduction: Diabetes mellitus is a risk factor for cardiovascular disease. Some recent studies have shown an association between diabetes and out-of-hospital cardiac arrest incidence and survival. We aimed to investigate whether there is an association between the presence of diabetes mellitus and survival after cardiopulmonary resuscitation (CPR) in patients with an in-hospital cardiac arrest. Methods: A cross-sectional study was conducted during the period of January to February 2014, among 80 cases of cardiopulmonary arrest in patients at Qaem hospital of Mashhad, Iran...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/29112279/nutrients-intake-and-serum-calcium-and-phosphorus-levels-an%C3%A2-evidence-based-study
#17
Zahra Jafari Giv, Amir Avan, Farshid Hamidi, Maryam Tayefi, Sayyed Saeid Khayyatzadeh, Ali Javandoost, Mohsen Nematy, Gordon A Ferns, Majid Ghayour Mobarhan
INTRODUCTION: Dietary calcium and phosphorus appear to be important determinants of dyslipidemia and hypertension. We have investigated (1) the prevalence of hypocalcemia and hypophosphatemia in an Iranian population, and (2) the association between nutrient's intake and serum levels of calcium and phosphorus. METHODS: A total of 908 individuals were enrolled using a stratified-cluster sampling method from the Mashhad stroke and heart atherosclerosis disorder (MASHHAD) study...
November 7, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29111585/tear-ferning-test-in-healthy-dogs
#18
Arianne P Oriá, Ana Claudia S Raposo, Nayone L L C Araújo, Felipe B Lima, Ali M Masmali
PURPOSE: To evaluate and compare three tear sampling methods using two grading scales for administering the tear ferning test (TFT) to healthy dogs. METHODS: In total, 90 dogs (180 eyes) were subjected to tear sampling using millimetered strips, reused after the Schirmer tear test (STT) (Schirmer group, SG). Then, the dogs were subdivided into three groups according to sampling approach: micropipette (MPG), microcapillary (MCG), and Schirmer sample 2 (S2G). The collected tears were dried on a clean microscope glass slide at room temperature and humidity...
November 7, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29111475/a-total-evidence-phylogeny-of-the-lady-fern-genus-athyrium-roth-athyriaceae-with-a-new-infrageneric-classification
#19
Ran Wei, Atsushi Ebihara, Yan-Mei Zhu, Cun-Feng Zhao, Sabine Hennequin, Xian-Chun Zhang
The lady fern genus Athyrium represents one of the most diversified lineages in Athyriaceae with about 160-220 known species, and is notorious for its taxonomic difficulty. Despite progress in recent phylogenetic studies involving this genus, it still lacks a modern systematic and taxonomic update using integrative analyses of molecular and morphological evidence based on a broad species sampling. Here, we present, to our knowledge, the most comprehensive phylogenetic analysis of the genus to date based on a total-evidence approach, covering all formerly accepted segregates within the athyrioid ferns...
October 27, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29109921/development-and-characterization-of-est-ssr-markers-via-transcriptome-sequencing-in-brainea-insignis-aspleniaceae-s-l
#20
Haijun Liu, Zhihua Yan, Hualing Xu, Chunmei Li, Qiang Fan, Wenbo Liao, Boyong Liao
Premise of the study: Brainea insignis (Aspleniaceae) is an endangered tree fern in China whose wild populations have been seriously damaged due to overexploitation. Expressed sequence tag-simple sequence repeat (EST-SSR) primers were developed to investigate its genetic diversity and provide resources for future conservation studies. Methods and Results: We obtained 72,897 unigenes of B. insignis using transcriptome sequencing and detected 15,006 SSRs in 12,058 unigenes...
October 2017: Applications in Plant Sciences
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