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https://www.readbyqxmd.com/read/28534120/serum-concentrations-of-mcp-1-and-il-6-in-combination-predict-the-presence-of-coronary-artery-disease-and-mortality-in-subjects-undergoing-coronary-angiography
#1
Mohammad Tajfard, Latiffah A Latiff, Hamid Reza Rahimi, Mohsen Moohebati, Mehdi Hasanzadeh, Ahmad Sarreshtehdar Emrani, Habibollah Esmaeily, Ali Taghipour, Sayed Reza Mirhafez, Gordon A Ferns, Maryam Mardan-Nik, Elham Mohammadzadeh, Amir Avan, Parichehr Hanachi, Majid Ghayour-Mobarhan
Cytokines play a key role in the pathogenesis of coronary artery disease (CAD). The aim of current study was to investigate the relationship between the serum concentrations of 12 cytokines with mortality and extent of CAD in individuals undergoing angiography and healthy controls. 342 CAD patients were recruited and divided into 2 groups: those with ≥50% occlusion in at least one coronary artery [Angiography (+)] or <50% obstruction in coronary arteries [Angiography (-)]. Also 120 healthy subjects were enrolled as control group...
May 22, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28530810/seleniranium-ions-undergo-%C3%AF-ligand-exchange-via-an-associative-mechanism-in-the-gas-phase
#2
Shea Fern Lim, Benjamin Leigh Harris, George N Khairallah, Evan John Bieske, Philippe Maître, Gabriel da Silva, Brian D Adamson, Michael S Scholz, Neville J A Coughlan, Richard A J O'Hair, Michael Rathjen, Daniel Stares, Jonathan M White
Collision-induced dissociation mass spectrometry of the ammonium ions 4a and 4b results in the formation of the seleniranium ion 5, the structure and purity of which was verified using gas phase infra-red spectroscopy coupled to mass spectrometry, and gas phase ion-mobility measurements. Ion-molecule reactions between the ion 5 (m/z = 261) and cyclopentene, cyclohexene, cycloheptene and cyclooctene, resulted in the formation of the seleniranium ions 7 (m/z = 225), 6 (m/z = 239), 8 (m/z = 253), and 9 (m/z = 267) respectively...
May 22, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28524205/structure-and-luminescence-analyses-of-simultaneously-synthesised-lu1-xgdx-2o2s-tb-3-and-lu1-xgdx-2o3-tb-3
#3
Natalie Pasberg, Daniel den Engelsen, George R Fern, Paul G Harris, Terry G Ireland, Jack Silver
Herein we describe the synthesis and luminescence of nanosized (Lu1-y-xGdx)2O2S:Tby and (Lu1-y-xGdx)2O3:Tby phosphors with y = 0.1 mol% Tb(3+) and y = 2 mol% Tb(3+) and x ranging between 0 and 1. The concentration of Gd(3+) (x) was varied in steps of 0.1 (molar ratio Gd(3+)). The samples at 0.1 < x < 0.7 contained a mixture of (Lu1-xGdx)2O3:Tb(3+) and (Lu1-xGdx)2O2S:Tb(3+), while the samples at x = 0 contained only Lu2O3:Tb(3+). At 0.1 < x < 0.7 Lu2O2S:Tb(3+) and Gd2O2S:Tb(3+) did not form a solid solution, but rather crystallised into two slightly different hexagonal structures...
May 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28513879/the-therapeutic-potential-of-pi3k-akt-mtor-inhibitors-in-breast-cancer-rational-and-progress
#4
Afsane Bahrami, Majid Khazaei, Soodabeh Shahidsales, Seyed Mahdi Hassanian, Malihe Hasanzadeh, Mina Maftouh, Gordon A Ferns, Amir Avan
Breast cancer is the most commonly diagnosed cancer in women. The PI3K/AKT/ mTOR pathway is among the most frequently dysregulated pathways in patients with breast cancer. The activation of this pathway is associated with increased cell growth and clinical outcome, and its overexpression is associated with a poor prognosis. It has been proposed that it may be of importance as a potential therapeutic target in the treatment of breast cancer. The aim of current review is to provide an overview of the potential utility of PI3K/Akt/mTOR inhibitors in patients with breast cancer, with particular emphasis on recent preclinical and clinical studies...
May 17, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28507289/cells-reprogramming-to-stem-cells-inhibit-the-reprogramming-of-adjacent-cells-in-the-moss-physcomitrella-patens
#5
Yoshikatsu Sato, Nagisa Sugimoto, Tadayoshi Hirai, Akihiro Imai, Minoru Kubo, Yuji Hiwatashi, Tomoaki Nishiyama, Mitsuyasu Hasebe
Under certain circumstances differentiated cells can be reprogrammed to form stem cells in land plants, but only a portion of the cells reprograms successfully. A long-distance inhibitory signal from reprogrammed cells to surrounding cells has been reported in some ferns. Here we show the existence of anisotropic inhibitory signal to regulate stem cell formation in the moss Physcomitrella patens. When single cells were isolated from a gametophore leaf, over 90% of them were reprogrammed to stem cells with characteristic nuclear expansion...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28506667/is-there-an-upper-limit-to-genome-size
#6
REVIEW
Oriane Hidalgo, Jaume Pellicer, Maarten Christenhusz, Harald Schneider, Andrew R Leitch, Ilia J Leitch
At 50-fold the size of the human genome (3 Gb), the staggeringly huge genome of 147.3 Gb recently discovered in the fern Tmesipteris obliqua is comparable in size to those of the other plant and animal record-holders (i.e., Paris japonica, a flowering plant with a genome size of 148.8 Gb, and Protopterus aethiopicus, a lungfish with a genome of 130 Gb). The synthesis of available information on giant genomes suggests that the biological limit to genome size expansion in eukaryotes may have been reached. We propose several explanations for why the genomes of ferns, flowering plants, and lungfish, all of which have independently undergone dramatic increases in genome size through a variety of mechanisms, do not exceed 150 Gb...
May 12, 2017: Trends in Plant Science
https://www.readbyqxmd.com/read/28505304/phytoplasma-conserved-phyllogen-proteins-induce-phyllody-across-the-plantae-by-degrading-floral-mads-domain-proteins
#7
Yugo Kitazawa, Nozomu Iwabuchi, Misako Himeno, Momoka Sasano, Hiroaki Koinuma, Takamichi Nijo, Tatsuya Tomomitsu, Tetsuya Yoshida, Yukari Okano, Nobuyuki Yoshikawa, Kensaku Maejima, Kenro Oshima, Shigetou Namba
ABCE-class MADS domain transcription factors (MTFs) are key regulators of floral organ development in angiosperms. Aberrant expression of these genes can result in abnormal floral traits such as phyllody. Phyllogen is a virulence factor conserved in phytoplasmas, plant pathogenic bacteria of the class Mollicutes. It triggers phyllody in Arabidopsis thaliana by inducing degradation of A- and E-class MTFs. However, it is still unknown whether phyllogen can induce phyllody in plants other than A. thaliana, although phytoplasma-associated phyllody symptoms are observed in a broad range of angiosperms...
May 15, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28501771/mechanisms-of-efficient-as-solubilization-in-soils-and-as-accumulation-by-as-hyperaccumulator-pteris-vittata
#8
REVIEW
Yong-He Han, Xue Liu, Bala Rathinasabapathi, Hong-Bo Li, Yanshan Chen, Lena Q Ma
Arsenic (As) in soils is of major environmental concern due to its ubiquity and carcinogenicity. Pteris vittata (Chinese brake fern) is the first known As-hyperaccumulator, which is highly efficient in extracting As from soils and translocating it to the fronds, making it possible to be used for phytoremediation of As-contaminated soils. In addition, P. vittata has served as a model plant to study As metabolisms in plants. Based on the recent advances, we reviewed the mechanisms of efficient As solubilization and transformation in rhizosphere soils of P...
May 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28497036/reversed-phase-hplc-dad-profiling-of-carotenoids-chlorophylls-and-phenolic-compounds-in-adiantum-capillus-veneris-leaves
#9
Alam Zeb, Fareed Ullah
Adiantum capillus-veneris is important endangered fern species with several medicinal properties. In this study, the leaves samples were extracted and separated using reversed phase HPLC with DAD for carotenoids, chlorophylls and phenolic compounds. Separation of carotenoids and chlorophylls were carried out using a tertiary gradient system of water, MTBE and methanol-water, while a binary gradient system of methanol-water-acetic acid was used for phenolic profiling. Results revealed eight carotenoids, four pheophytins, and two chlorophylls...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28496454/expression-analyses-of-embryogenesis-associated-genes-during-somatic-embryogenesis-of-adiantum-capillus-veneris-l-in-vitro-new-insights-into-the-evolution-of-reproductive-organs-in-land-plants
#10
Xia Li, Jing-Dan Han, Yu-Han Fang, Shu-Nong Bai, Guang-Yuan Rao
An efficient in vitro regeneration system via somatic embryogenesis (SE) was developed for a fern species Adiantum capillus-veneris. Adventitious shoots, green globular bodies (GGBs) and calli were obtained with the maximal induction rate on the Murashige and Skoog (MS) medium of low concentrations of 6-benzyladenine (BA) (0-1.0 mg/L), 2.0 mg/L BA without 2,4-dichlorophenoxyacetic acid (2,4-D), 0.5 mg/L 2,4-D and 0.5-1.0 mg/L 6-BA, respectively. Cyto-morphological and histological changes in the shoot development via calli and GGBs were examined...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28494025/sequencing-of-small-rnas-of-the-fern-pleopeltis-minima-polypodiaceae-offers-insight-into-the-evolution-of-the-microrna-repertoire-in-land-plants
#11
Florencia Berruezo, Flávio S J de Souza, Pablo I Picca, Sergio I Nemirovsky, Leandro Martínez Tosar, Mercedes Rivero, Alejandro N Mentaberry, Alicia M Zelada
MicroRNAs (miRNAs) are short, single stranded RNA molecules that regulate the stability and translation of messenger RNAs in diverse eukaryotic groups. Several miRNA genes are of ancient origin and have been maintained in the genomes of animal and plant taxa for hundreds of millions of years, playing key roles in development and physiology. In the last decade, genome and small RNA (sRNA) sequencing of several plant species have helped unveil the evolutionary history of land plants. Among these, the fern group (monilophytes) occupies a key phylogenetic position, as it represents the closest extant cousin taxon of seed plants, i...
2017: PloS One
https://www.readbyqxmd.com/read/28493884/non-linear-growth-in-tree-ferns-dicksonia-antarctica-and-cyathea-australis
#12
David P Blair, Wade Blanchard, Sam C Banks, David B Lindenmayer
Tree ferns are an important structural component of forests in many countries. However, because their regeneration is often unrelated to major disturbances, their age is often difficult to determine. In addition, rates of growth may not be uniform, which further complicates attempts to determine their age. In this study, we measured 5 years of growth of Cyathea australis and Dicksonia antarctica after a large wildfire in 2009 in south-eastern Australia. We found growth rates of these two species were unaffected by aspect and elevation but slope had a minor effect with D...
2017: PloS One
https://www.readbyqxmd.com/read/28491120/microscopy-of-physcomitrella-patens-sperm-cells
#13
Nelly A Horst, Ralf Reski
BACKGROUND: Archegoniates (bryophytes, ferns and gymnosperms), such as the moss Physcomitrella patens, possess freely motile sperm cells (spermatozoids) which reach the egg cell via surface water. Although these motile flagellated sperm cells are a traditional botanical subject, they have not been thoroughly analysed in the flagship non-seed plant model species P. patens. Protocols are required to determine the behaviour of wild type sperms as a prerequisite for future research such as the characterization of mutants or factors that influence sperm number, morphology, viability and motility...
2017: Plant Methods
https://www.readbyqxmd.com/read/28486907/effect-of-crocin-on-antibody-titers-to-heat-shock-protein-27-in-subjects-with-metabolic-syndrome
#14
Mina Nosrati, Irandokht Nikbakht-Jam, Saeid Eslami, M Khademi, Mojtaba Foroutan-Tanha, Farzin Hadizadeh, Amir Hosein Sahebkar, Shima Tavallaie, Zhila Taherzadeh, Majid Ghayour-Mobarhan, Gordon A A Ferns
BACKGROUND: Recent studies have shown that antibody titers to heat shock protein 27 (anti-hsp27) and hs-CRP concentrations are elevated in patients with MetS, and may be associated with an increased cardiovascular diseases risk. Crocin is a natural carotenoid with, cardio protective effects. OBJECTIVE: Owing to the previous evidence on the beneficial effects of saffron in patients with MetS, this study investigated the effect of supplementation with crocin, as the active ingredient of saffron, on serum anti-hsp27 and hs-CRP in patients with MetS...
May 9, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28485990/comparison-among-soil-additives-for-enhancing-the-pteris-vittata-l-phytoremediation-of-as-contaminated-soil
#15
Jun Yang, Shu-Shen Yang, Mei Lei, Jun-Xing Yang, Xiao-Ming Wan, Tong-Bin Chen, Xiao-Ling Wang, Guang-Hui Guo, Jun-Mei Guo, Shu-Qing Liu
Pot experiments were conducted to assess the effects of monoammonium phosphate (NH4H2PO4) and citric acid (CA) on the arsenic uptake of Chinese brake fern (Pteris vittata L. in two typical arsenic-contaminated soils (fluvo-aquic and brown soils) from Jiyuan City and Baoding City in northern China. NH4H2PO4 improved the biomass of P. vittata, whereas CA exerted no significant influence. NH4H2PO4 and CA both increased the arsenic uptake of P. vittata by 6.08 and 2.72 times, respectively, in fluvo-aquic soil and 4...
May 9, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28479155/treatment-with-glp1-receptor-agonists-reduce-serum-crp-concentrations-in-patients-with-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#16
REVIEW
Mohsen Mazidi, Ehsan Karimi, Peyman Rezaie, Gordon A Ferns
AIM: To undertake a systematic review and meta-analysis of randomized controlled trials of the effect of glucagon-like peptide-1 receptor agonist (GLP-1 RAs) therapy on serum C-reactive protein (CRP) concentrations. METHOD: PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases were searched for the period up until March 16, 2016. Prospective studies evaluating the impact of GLP-1 RAs on serum CRP were identified. A random effects model (using the DerSimonian-Laird method) and generic inverse variance methods were used for quantitative data synthesis...
May 30, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28475243/the-potential-value-of-the-pi3k-akt-mtor-signaling-pathway-for-assessing-prognosis-in-cervical-cancer-and-as-a-target-for-therapy
#17
Afsane Bahrami, Malihe Hasanzadeh, Seyed Mahdi Hassanian, Soodabeh ShahidSales, Majid Ghayour Mobarhan, Gordon A Ferns, Amir Avan
Cervical cancer is a common gynecological cancer and a leading cause of cancer-related death in women globally. There is a need for the identification of prognostic and predictive biomarker for risk stratification. The phosphatidylinositol 3-kinase/ protein kinase B/ mammalian target of rapamycin (PI3K/ Akt/ mTOR) pathway is often dysregulated in cervical cancer, indicating that it may be a potential therapeutic target in the treatment of this malignancy, and could perhaps be used as a novel biomarker in the assessment of risk of developing cervical cancer...
May 5, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28467150/impact-of-zinc-supplementation-on-the-clinical-outcomes-of-patients-with-severe-head-trauma-a-double-blind-randomized-clinical-trial
#18
Maryam Khazdouz, Mohsen Mazidi, Mohammad-Reza Ehsaei, Gordon Ferns, Andre Pascal Kengne, Abdol-Reza Norouzy
To determine the effects of zinc supplementation on clinical outcomes of patients with severe head trauma, this double-blind clinical trial randomly allocated 100 patients with severe head trauma, aged between 18 to 65 years, to receive placebo or 120 mg zinc via a nasogastric tube for 15 days. Plasma zinc and copper, 24-hour urinary zinc excretion, Sequential Organ Failure Assessment (SOFA) were assessed on days 1, 7, and 16. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and white blood cell (WBC) count were measured on days 1 and 16...
May 3, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28466867/enzyme-discovery-beyond-homology-a-unique-hydroxynitrile-lyase-in-the-bet-v1-superfamily
#19
Elisa Lanfranchi, Tea Pavkov-Keller, Eva-Maria Koehler, Matthias Diepold, Kerstin Steiner, Barbara Darnhofer, Jürgen Hartler, Tom Van Den Bergh, Henk-Jan Joosten, Mandana Gruber-Khadjawi, Gerhard G Thallinger, Ruth Birner-Gruenberger, Karl Gruber, Margit Winkler, Anton Glieder
Homology and similarity based approaches are most widely used for the identification of new enzymes for biocatalysis. However, they are not suitable to find truly novel scaffolds with a desired function and this averts options and diversity. Hydroxynitrile lyases (HNLs) are an example of non-homologous isofunctional enzymes for the synthesis of chiral cyanohydrins. Due to their convergent evolution, finding new representatives is challenging. Here we show the discovery of unique HNL enzymes from the fern Davallia tyermannii by coalescence of transcriptomics, proteomics and enzymatic screening...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28460742/revisiting-an-old-disease-risk-factors-for-bovine-enzootic-haematuria-in-the-kingdom-of-bhutan
#20
Arata Hidano, Basant Sharma, Karma Rinzin, Narapati Dahal, Kinzang Dukpa, Mark A Stevenson
Bovine enzootic haematuria (BEH) is a debilitating disease of cattle caused by chronic ingestion of bracken fern. Control of BEH is difficult when bracken fern is abundant and fodder resources are limited. To fill a significant knowledge gap on modifiable risk factors for BEH, we conducted a case-control study to identify cattle management practices associated with BEH in the Bhutanese cattle population. A case-control study involving 16 of the 20 districts of Bhutan was carried out between March 2012 and June 2014...
May 1, 2017: Preventive Veterinary Medicine
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