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https://www.readbyqxmd.com/read/27904081/development-of-a-novel-milling-system-using-supercritical-carbon-dioxide-for-improvement-of-dissolution-characteristics-of-water-poorly-soluble-drugs
#1
Jennifer Chia Wee Fern, Hideya Nakamura, Satoru Watano
The aim of this study is to develop a novel milling system using supercritical carbon dioxide (SC-CO2) for the improvement of dissolution characteristics of water-poorly soluble drugs. SC-CO2 possesses high potential in the application of nanotechnology, due to the attractive properties of SC-CO2 fluid such as cheap, inert and non-polluting. In addition, SC-CO2 has density comparable to a liquid, viscosity similar to a gas, and high diffusion capacity. Most of all, carbon dioxide exists as gas in room temperature and pressure, which enables the removal of fluid instantaneously...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27896030/historical-reconstruction-of-climatic-and-elevation-preferences-and-the-evolution-of-cloud-forest-adapted-tree-ferns-in-mesoamerica
#2
Victoria Sosa, Juan Francisco Ornelas, Santiago Ramírez-Barahona, Etelvina Gándara
BACKGROUND: Cloud forests, characterized by a persistent, frequent or seasonal low-level cloud cover and fragmented distribution, are one of the most threatened habitats, especially in the Neotropics. Tree ferns are among the most conspicuous elements in these forests, and ferns are restricted to regions in which minimum temperatures rarely drop below freezing and rainfall is high and evenly distributed around the year. Current phylogeographic data suggest that some of the cloud forest-adapted species remained in situ or expanded to the lowlands during glacial cycles and contracted allopatrically during the interglacials...
2016: PeerJ
https://www.readbyqxmd.com/read/27895918/classical-and-non-classical-hla-class-i-aberrations-in-primary-cervical-squamous-and-adenocarcinomas-and-paired-lymph-node-metastases
#3
Debbie M Ferns, A Marijne Heeren, Sanne Samuels, Maaike C G Bleeker, Tanja D de Gruijl, Gemma G Kenter, Ekaterina S Jordanova
BACKGROUND: Tumors avoid destruction by cytotoxic T cells (CTL) and natural killer (NK) cells by downregulation of classical human leukocyte antigens (HLA) and overexpression of non-classical HLA. This is the first study to investigate HLA expression in relation to histology (squamous cell carcinoma (SCC) vs. adenocarcinoma (AC)), clinicopathological parameters and survival in a large cervical cancer patient cohort. METHODS: Classical (HLA-A and HLA-B/C)- and non-classical HLA molecules (HLA-E and HLA-G) were studied on primary tumors and paired lymph node (LN) metastases from cervical cancer patients (n = 136) by immunohistochemistry...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27895478/biosynthesis-characterization-and-evaluation-of-bioactivities-of-leaf-extract-mediated-biocompatible-silver-nanoparticles-from-an-early-tracheophyte-pteris-tripartita-sw
#4
Xavierravi Baskaran, Antony Varuvel Geo Vigila, Thangaraj Parimelazhagan, Doulathabad Muralidhara-Rao, Shouzhou Zhang
The objective of the study was to characterize silver nanoparticles (Ag-NPs) and their bioactivities in early tracheophytes (Pteridophyta). Aqueous leaf extract of a critically endangered fern, Pteris tripartita Sw., was used for one-step green synthesis of Ag-NPs. The biosynthesized Ag-NPs were characterized using ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and high-resolution transmission electron microscopy...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27893522/zone-i-of-tear-microdesiccates-is-a-lipid-containing-structure
#5
Felipe Traipe, Leonidas Traipe, Daniela Salinas-Toro, Daniela López, Felipe Valenzuela, Claudio Pérez, Cristian Cartes, Francisca Zuazo, Patricia Varela, Héctor Toledo-Araya, Remigio López-Solís
PURPOSE: Morphological features of tear microdesiccates on glass surfaces have been associated with tear fluid status. Tear-film lipids play a critical role in the pathophysiology of some ocular surface disorders. Tear microdesiccates display 4 distinctive morphological domains (zones I, II, III, and transition band). In this study, we investigated the lipid location in tear microdesiccates. METHODS: Tear from individual healthy eyes (assessed by symptoms, signs, and slit-lamp examination) was collected using absorbing minisponges...
November 23, 2016: Cornea
https://www.readbyqxmd.com/read/27892872/fern-synthesized-silver-nanocrystals-towards-a-new-class-of-mosquito-oviposition-deterrents
#6
Rajapandian Rajaganesh, Kadarkarai Murugan, Chellasamy Panneerselvam, Sudalaimani Jayashanthini, Al Thbiani Aziz, Mathath Roni, Udaiyan Suresh, Subrata Trivedi, Hasibur Rehman, Akon Higuchi, Marcello Nicoletti, Giovanni Benelli
Mosquitoes act as vectors of devastating pathogens and parasites, representing a key threat for millions of humans and animals worldwide. Eco-friendly control tools are urgently required. We proposed a novel method of fern-mediated biosynthesis of silver nanoparticles (AgNP) using Dicranopteris linearis, acting as a reducing and capping agent. AgNP were characterized by UV-vis spectroscopy, Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), zeta potential and particle size analysis...
September 17, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27890967/airborne-pollen-and-fungal-spores-in-garki-abuja-north-central-nigeria
#7
Dimphna Nneka Ezike, Catherine V Nnamani, Oluwatoyin T Ogundipe, Olushola H Adekanmbi
The ambient atmosphere is dominated with pollen and spores, which trigger allergic reactions and diseases and impact negatively on human health. A survey of pollen and fungal spores constituents of the atmosphere of Garki, Abuja (North-Central Nigeria) was carried out for 1 year (June 1, 2011-May 31, 2012). The aim of the study was to determine the prevalence and abundance of pollen and fungal spores in the atmosphere and their relationship with meteorological parameters. Airborne samples were trapped using modified Tauber-like pollen trap, and the recipient solutions were subjected to acetolysis...
2016: Aerobiologia
https://www.readbyqxmd.com/read/27889245/selagintriflavonoids-with-bace1-inhibitory-activity-from-the-fern-selaginella-doederleinii
#8
Zhenxing Zou, Pingsheng Xu, Guogang Zhang, Fei Cheng, Kai Chen, Jing Li, Weixing Zhu, Dongsheng Cao, Kangping Xu, Guishan Tan
Eight triflavonoids, selagintriflavonoids A-H, were isolated from whole herbs of Selaginella doederleinii. The structures of compounds selagintriflavonoids A-C consisted of three naringenin units, whereas those of selagintriflavonoids D-H consisted of apigenin and two naringenin moieties. The structures and absolute configurations of the compounds were determined based on NMR, HRESIMS, and experimental and calculated electronic circular dichroism (ECD) data. The ability of the compounds to inhibit β-secretase (BACE1) was also evaluated...
November 23, 2016: Phytochemistry
https://www.readbyqxmd.com/read/27887971/biosorption-of-u-vi-by-modified-hottentot-fern-kinetics-and-equilibrium-studies
#9
Ke Zhou, Yaochi Liu, Zhaoguang Yang, Houzhi Liu
Batch experiments were conducted to investigate the biosorption of U(VI) onto Hottentot Fern (Cyclosorus interruptus). The selective adsorption, the adsorption of different sections of Cyclosorus interruptus (CI), and the adsorption of polluted CI compared with that of unpolluted one were studied in detail. The raw CI and the CI modified by CaCl2, MgCl2, MgCl2/H2O2 were investigated for adsorption of U(VI) from aqueous solution. The results indicate that raw CI showed good adsorption selectivity for U(VI), compared with the adsorption of Cu(II), Co(II) and Ni(II)...
November 22, 2016: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/27886385/nonreciprocal-complementation-of-knox-gene-function-in-land-plants
#10
Eftychios Frangedakis, Denis Saint-Marcoux, Laura A Moody, Ester Rabbinowitsch, Jane A Langdale
Class I KNOTTED-LIKE HOMEOBOX (KNOX) proteins regulate development of the multicellular diploid sporophyte in both mosses and flowering plants; however, the morphological context in which they function differs. In order to determine how Class I KNOX function was modified as land plants evolved, phylogenetic analyses and cross-species complementation assays were performed. Our data reveal that a duplication within the charophyte sister group to land plants led to distinct Class I and Class II KNOX gene families...
November 25, 2016: New Phytologist
https://www.readbyqxmd.com/read/27876159/natural-radionuclides-in-lichens-mosses-and-ferns-in-a-thermal-power-plant-and-in-an-adjacent-coal-mine-area-in-southern-brazil
#11
Juliana Aparecida Galhardi, Rafael García-Tenorio, Inmaculada Díaz Francés, Daniel Marcos Bonotto, Marcelo Pinto Marcelli
The radio-elements (234)U, (235)U, (238)U, (230)Th, (232)Th and (210)Po were characterized in lichens, mosses and ferns species sampled in an adjacent coal mine area at Figueira City, Paraná State, Brazil, due to their importance for the assessment of human exposure related to the natural radioactivity. The coal is geologically associated with a uranium deposit and has been used as a fossil fuel in a thermal power plant in the city. Samples were initially prepared at LABIDRO (Isotopes and Hydrochemistry Laboratory), UNESP, Rio Claro (SP), Brazil...
November 18, 2016: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/27861906/all-optical-functional-synaptic-connectivity-mapping-in-acute-brain-slices-using-campari
#12
Timothy A Zolnik, Fern Sha, Friedrich Johenning, Eric R Schreiter, Loren L Looger, Matthew E Larkum, Robert N S Sachdev
The calcium-modulated photoactivatable ratiometric integrator CaMPARI (Fosque et al., 2015) facilitates the study of neural circuits by permanently marking cells active during user-specified temporal windows. Permanent marking enables measurement of signals from large swathes of tissue and easy correlation of activity with other structural or functional labels. One potential application of CaMPARI is labeling neurons postsynaptic to specific populations targeted for optogenetic stimulation, giving rise to all-optical functional connectivity mapping...
November 11, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27859339/ferns-mosses-and-liverworts-as-model-systems-for-light-mediated-chloroplast-movements
#13
REVIEW
Noriyuki Suetsugu, Takeshi Higa, Masamitsu Wada
Light-induced chloroplast movement is found in most plant species, including algae and land plants. In land plants with multiple small chloroplasts, under weak light conditions, the chloroplasts move towards the light and accumulate on the periclinal cell walls to efficiently perceive light for photosynthesis (the accumulation response). Under strong light conditions, chloroplasts escape from light to avoid photodamage (the avoidance response). In most plant species, blue light induces chloroplast movement and phototropin receptor kinases are the blue light receptors...
November 17, 2016: Plant, Cell & Environment
https://www.readbyqxmd.com/read/27858850/impact-of-different-types-of-tree-nut-peanut-and-soy-nut-consumption-on-serum-c-reactive-protein-crp-a-systematic-review-and-meta-analysis-of-randomized-controlled-clinical-trials
#14
Mohsen Mazidi, Peyman Rezaie, Gordon A Ferns, Hong-Kai Gao
BACKGROUND: The effects of different types of tree nut, peanut, and soy nut consumption on serum C - reactive protein (CRP) are not well established. we aimed to undertake a systematic review and meta-analysis of prospective studies to determine the effect of nut consumption (tree nuts, peanuts, and soy nuts) on serum CRP. METHOD: PubMed-Medline, Web of Science, Cochrane Database, and Google Scholar databases were searched (up until April 20 2016) to identify prospective studies evaluating the impact of tree nut, peanut, and soy nut consumption on serum CRP...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27857075/linear-ubiquitin-chain-assembly-complex-coordinates-late-thymic-t-cell-differentiation-and-regulatory-t-cell-homeostasis
#15
Charis E Teh, Najoua Lalaoui, Reema Jain, Antonia N Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A O'Reilly, Dale I Godfrey, Gordon K Smyth, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke, Daniel H D Gray
The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive immunity is unclear. Here we show that the LUBAC components HOIP, HOIL-1 and SHARPIN have essential roles in late thymocyte differentiation, FOXP3(+) regulatory T (Treg)-cell development and Treg cell homeostasis. LUBAC activity is not required to prevent TNF-induced apoptosis or necroptosis but is necessary for the transcriptional programme of the penultimate stage of thymocyte differentiation...
November 18, 2016: Nature Communications
https://www.readbyqxmd.com/read/27855117/comparison-of-the-duo-of-insulin-like-growth-factor-binding-protein-1-alpha-fetoprotein-amnioquick-duo-%C3%A2-and-traditional-clinical-assessment-for-diagnosing-premature-rupture-of-fetal-membranes
#16
George Uchenna Eleje, Euzebus Chinonye Ezugwu, Ahizechukwu Chigoziem Eke, Joseph Ifeanyichukwu Ikechebelu, Chukwudi Celestine Obiora, Nnabuike Okechukwu Ojiegbe, Ifeanyichukwu Uzoma Ezebialu, Chukwuemeka Okwudili Ezeama, Betrand Obi Nwosu, Gerald Okanandu Udigwe, Charles Ikechukwu Okafor, Frank Okechukwu Ezugwu
PURPOSE: To determine the diagnostic accuracy of insulin-like growth factor binding protein-1/alpha fetoprotein (Amnioquick duo+®) compared with traditional clinical assessment (TCA) of nitrazine, ferning and pooling for the diagnosis of prelabor rupture of membranes (PROM). METHODS: A double-blinded, multicenter clinical study was conducted between February 2015 and August 2015 among pregnant women presenting with symptoms or features suggestive of PROM between 24 and 42 weeks gestation...
November 17, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27853737/validation-of-diagnostic-characteristics-of-needle-based-confocal-laser-endomicroscopy-in-differentiation-of-pancreatic-cystic-lesions
#17
Somashekar G Krishna, Benjamin Swanson, Phil A Hart, Samer El-Dika, Jon P Walker, Sean T McCarthy, Ahmad Malli, Zarine K Shah, Darwin L Conwell
: Background and aims: Endoscopic ultrasound (EUS)-guided needle-based Confocal Laser Endomicroscopy (nCLE) characteristics of pancreatic cystic lesions (PCLs) have been identified in studies where the gold standard surgical histopathology was available in a minority of patients. There are diverging reports of interobserver agreement (IOA) and paucity of intraobserver reliability (IOR). Thus, we sought to validate current EUS-nCLE criteria of PCLs in a larger consecutive series of surgical patients...
November 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27852123/acanthopanax-senticosus-photochemistry-and-anticancer-potential
#18
Ting Li, Kelsey Ferns, Zi-Qiao Yan, Si-Yuan Yin, Jun-Jie Kou, Dongsheng Li, Zheng Zeng, Lin Yin, Xiaoyu Wang, Hong-Xia Bao, Yu-Jie Zhou, Qing-Hai Li, Zhan-Yi Zhao, Huidi Liu, Shu-Lin Liu
Acanthopanax senticosus (previously classified as Eleutherococcus senticosus), commonly known as Ciwujia or Siberian Ginseng, is a traditional Chinese medicine (TCM), widely used for its high medicinal value, such as antifatigue, anti-inflammation, antistress, anti-ulcer and cardiovascular functions, in China, Korea, Japan and Russia. In the past decades, researchers worldwide have conducted systematic investigations on this herb, from chemistry to pharmacology, and a large number of chemical components have been characterized for their significant pharmacological effects...
November 16, 2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27848090/environmental-geochemistry-of-the-abandoned-mamut-copper-mine-sabah-malaysia
#19
Antony van der Ent, Mansour Edraki
The Mamut Copper Mine (MCM) located in Sabah (Malaysia) on Borneo Island was the only Cu-Au mine that operated in the country. During its operation (1975-1999), the mine produced 2.47 Mt of concentrate containing approximately 600,000 t of Cu, 45 t of Au and 294 t of Ag, and generated about 250 Mt of overburden and waste rocks and over 150 Mt of tailings, which were deposited at the 397 ha Lohan tailings storage facility, 15.8 km from the mine and 980 m lower in altitude. The MCM site presents challenges for environmental rehabilitation due to the presence of large volumes of sulphidic minerals wastes, the very high rainfall and the large volume of polluted mine pit water...
November 15, 2016: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/27843165/neonatal-mortality-within-24%C3%A2-hours-of-birth-in-six-low-and-lower-middle-income-countries
#20
Abdullah H Baqui, Dipak K Mitra, Nazma Begum, Lisa Hurt, Seyi Soremekun, Karen Edmond, Betty Kirkwood, Nita Bhandari, Sunita Taneja, Sarmila Mazumder, Muhammad Imran Nisar, Fyezah Jehan, Muhammad Ilyas, Murtaza Ali, Imran Ahmed, Shabina Ariff, Sajid B Soofi, Sunil Sazawal, Usha Dhingra, Arup Dutta, Said M Ali, Shaali M Ame, Katherine Semrau, Fern M Hamomba, Caroline Grogan, Davidson H Hamer, Rajiv Bahl, Sachiyo Yoshida, Alexander Manu
OBJECTIVE: To estimate neonatal mortality, particularly within 24 hours of birth, in six low- and lower-middle-income countries. METHODS: We analysed epidemiological data on a total of 149 570 live births collected between 2007 and 2013 in six prospective randomized trials and a cohort study from predominantly rural areas of Bangladesh, Ghana, India, Pakistan, the United Republic of Tanzania and Zambia. The neonatal mortality rate and mortality within 24 hours of birth were estimated for all countries and mortality within 6 hours was estimated for four countries with available data...
October 1, 2016: Bulletin of the World Health Organization
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