Nonthalert Lertnitikul, Ladawan Teerasukpimol, Pattatorn Aekanantakul, Naphatsawan Pooreecharurot, Suchada Sukrong, Cherdsak Boonyong, Preeyaporn Poldorn, Thanyada Rungrotmongkol, Edwin Risky Sukandar, Chanat Aonbangkhen, Rutt Suttisri
One new alkyl benzoquinone, paphionone ( 1 ), one new trans- stilbenoid, ( E )-6,5'-dihydroxy-2,3'-dimethoxystilbene ( 2 ), and eight known stilbenoids and flavonoids ( 3 - 10 ) were isolated from the leaves and roots of Paphiopedilum exul (Orchidaceae). Their chemical structures were determined based on IR, ECD, MS and NMR analyses. Cytotoxicity of all isolated compounds towards human hepatocellular carcinoma (HepG2) cell line was examined in vitro by MTT assay. The para -hydroxybenzyl substituted stilbene 10 was potently cytotoxic to the cancer cells, with an IC50 value of 4...
April 22, 2024: Natural Product Research