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https://www.readbyqxmd.com/read/28728356/antioxidant-potential-of-cheddar-cheeses-to-tackle-human-colon-adenocarcinoma-caco-2-cells
#1
Nuzhat Huma, Saima Rafiq, Aysha Sameen, Imran Pasha, Muhammad Issa Khan
Objective: Increased production of reactive oxygen species (ROS) affects gastrointestinal system which may develop intestinal pathologies. Food resources comprising natural antioxidants with chemotherapeutic properties have greater demand in current marketplace Therefore, aim of present study was to assess the anti-oxidant potential of water-soluble peptides (WSPs) extract derived from buffalo and cow milk Cheddar cheeses at different stages of ripening. Methods: The antioxidant potential of WSPs extract was assessed through ABTS-radical scavenging activity...
June 27, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28728306/-interpretation-of-guidance-for-establishing-the-performance-characteristics-of-in-vitro-diagnostic-devices-for-the-detection-or-detection-and-differentiation-of-high-risk-human-papillomaviruses-issued-by-food-and-drug-administration-of-united-states-and-china
#2
R M Feng, W Chen, Y L Qiao
To establish the standardization of clinical verification designs for in vitro diagnostic devices(IVDs) of human papillomavirus, China Food and Drug Administration (CFDA) and United States Food and Drug Administration (FDA) issued guidelines of detailed study designs and effectiveness evaluation for accuracy validation and clinical performance of nucleic acid detection, respectively, including triage of a typical squamous cells of undetermined significance(ASC-US) patients and validation of combined screening and preliminary screening...
July 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28728086/nanostructured-lipid-systems-modified-with-waste-material-of-propolis-for-wound-healing-design-in-vitro-and-in-vivo-evaluation
#3
Hélen Cássia Rosseto, Lucas de Alcântara Sica de Toledo, Lizziane Maria Belloto de Francisco, Elisabetta Esposito, Yunsook Lim, Giuseppe Valacchi, Rita Cortesi, Marcos Luciano Bruschi
Propolis, a natural compound that can accelerate the wound healing process, is mainly used as ethanolic extract. The extractive solution may also be obtained from the propolis by-product (BP), transforming this waste material into a pharmaceutical active ingredient. Even if propolis does not show toxicity, when used as an extract over harmed skin or mucosa, the present ethanol content may be harmful to the tissue recovering, besides hindering the drug release. This study describes the development of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) as topical propolis delivery systems and the investigation of their in vitro and in vivo activities...
July 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28728085/preparation-of-a-6-oh-quaternized-chitosan-derivative-through-click-reaction-and-its-application-to-novel-thermally-induced-polyelectrolyte-complex-hydrogels
#4
Yu Chen, Fengju Wang, Na Zhang, Yi Li, Bin Cheng, Yongfa Zheng
In the present study, a chitosan derivative with long chain quaternary ammonium locating grafted at 6-OH (CTS-6-QAS) was designed and prepared via a novel click reaction. The structure and thermal stability of the products of each step were determined with Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA). Rheological tests indicate that CTS-6-QAS possesses excellent thermally induced hydrogel formation property in the presence of β-glycerophosphate (β-GP)...
July 11, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28727820/active-hexose-correlated-compound-enhances-extrinsic-pathway-mediated-apoptosis-of-acute-myeloid-leukemic-cells
#5
Kavin Fatehchand, Ramasamy Santhanam, Brenda Shen, Ericka L Erickson, Shalini Gautam, Saranya Elavazhagan, Xiaokui Mo, Tesfaye Belay, Susheela Tridandapani, Jonathan P Butchar
Active Hexose Correlated Compound (AHCC) has been shown to have many immunostimulatory and anti-cancer activities in mice and in humans. As a natural product, AHCC has potential to create safer adjuvant therapies in cancer patients. Acute Myeloid Leukemia (AML) is the least curable and second-most common leukemia in adults. AML is especially terminal to those over 60 years old, where median survival is only 5 to 10 months, due to inability to receive intensive chemotherapy. Hence, the purpose of this study was to investigate the effects of AHCC on AML cells both in vitro and in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28727443/plasmonic-thermal-decomposition-digestion-of-proteins-a-rapid-on-surface-protein-digestion-technique-for-mass-spectrometry-imaging
#6
Rong Zhou, Franco Basile
A method based on plasmon surface resonance absorption and heating was developed to perform a rapid on-surface protein thermal decomposition and digestion suitable for imaging MS and/or profiling. This photo-thermal process or plasmonic thermal decomposition/digestion (plasmonic-TDD) method incorporates a continuous wave (CW) laser excitation and gold nanoparticles (Au-NPs) to induce known thermal decomposition reactions that cleave peptides and proteins specifically at the C-terminus of aspartic acid and at the N-terminus of cysteine...
July 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28727431/pd-catalyzed-iodide-promoted-%C3%AE-arylation-of-ketones-for-the-regioselective-synthesis-of-isocoumarins
#7
Alessandra Casnati, Raimondo Maggi, Giovanni Maestri, Nicola Della Ca', Elena Motti
A variety of isocoumarins have been synthesized directly from 2-halobenzoates and ketones through a palladium-catalyzed α-arylation step followed by an intramolecular cyclization process. The addition of iodide anions to the reaction mixture increased yields and selectivities especially when 2-bromobenzoates were employed. This phosphine-free one-pot synthesis features a high functional group tolerance and gives access to richly decorated isocoumarins. This general methodology was successful in the total synthesis of Xyridin A, an important natural product with antibacterial and antifungal activity...
July 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28727214/what-plant-functional-traits-can-reduce-nitrous-oxide-emissions-from-intensively-managed-grasslands
#8
Diego Abalos, Jan Willem van Groenigen, Gerlinde B De Deyn
Plant species exert a dominant control over the nitrogen (N) cycle of natural and managed grasslands. Although in intensively managed systems that receive large external N inputs the emission of the potent greenhouse gas nitrous oxide (N2 O) is a crucial component of this cycle, a mechanistic relationship between plant species and N2 O emissions has not yet been established. Here we use a plant functional trait approach to study the relation between plant species strategies and N2 O emissions from soils. Compared to species with conservative strategies, species with acquisitive strategies have higher N uptake when there is ample N in the soil, but also trigger N mineralization when soil N is limiting...
July 20, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28727177/total-synthesis-of-the-marine-natural-product-hemiasterlin-via-organocatalyzed-%C3%AE-hydrazination
#9
Thomas Lindel, Jan Hendrik Lang, Peter G Jones
An efficient synthesis of the potently cytotoxic marine peptide hemiasterlin is presented. The tetramethyltryptophan moiety is assembled via tert.-prenylation of indole, followed by the high-yielding, organocatalyzed α-hydrazination of a sterically congested aldehyde with excellent enantioselectivity. BEP-mediated peptide coupling completes the synthesis, being the first approach that does not employ chiral auxiliaries. A novel phenonium-type rearrangement of the indole system occurred when subjecting dihydroxylated 3-tert...
July 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28727090/effect-of-natural-betaine-and-ractopamine-hcl-on-whole-body-and-carcass-growth-in-pigs-housed-under-high-ambient-temperatures
#10
S M Mendoza, R D Boyd, C E Zier-Rush, P R Ferket, K D Haydon, E van Heugten
Betaine is an osmolyte that helps to maintain water homeostasis and cell integrity, which is essential during heat stress. We hypothesized that supplemental betaine can improve growth during heat stress and may further improve the response to ractopamine. Two studies were conducted to determine: 1) the effects of betaine in combination with ractopamine; and 2) the optimum betaine level for late finishing pigs during heat stress. Heat stress was imposed by gradually increasing temperatures over 10 d to the target high temperature of 32°C...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726920/pheomelanin-molecular-vibration-is-associated-with-mitochondrial-ros-production-in-melanocytes-and-systemic-oxidative-stress-and-damage
#11
Ismael Galván, Alberto Jorge, María García-Gil
Vibrations in covalent bonds affect electron delocalization within molecules, as reported in polymers. If synthesized by living cells, the electron delocalization of polymers affects the stabilization of cellular free radicals, but biomolecular vibration has never been considered a potential source of cytotoxicity. Here we show that the vibrational characteristics of natural pheomelanin and eumelanin contribute to feather color expression in four poultry breeds with different melanin-based pigmentation patterns, but only the vibrational characteristics of pheomelanin are related to the production of reactive oxygen species (ROS) in the mitochondria of melanocytes and to systemic levels of cellular oxidative stress and damage...
July 20, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28726827/nitrogen-reduction-and-functionalization-by-a-multimetallic-uranium-nitride-complex
#12
Marta Falcone, Lucile Chatelain, Rosario Scopelliti, Ivica Živković, Marinella Mazzanti
Molecular nitrogen (N2) is cheap and widely available, but its unreactive nature is a challenge when attempting to functionalize it under mild conditions with other widely available substrates (such as carbon monoxide, CO) to produce value-added compounds. Biological N2 fixation can do this, but the industrial Haber-Bosch process for ammonia production operates under harsh conditions (450 degrees Celsius and 300 bar), even though both processes are thought to involve multimetallic catalytic sites. And although molecular complexes capable of binding and even reducing N2 under mild conditions are known, with co-operativity between metal centres considered crucial for the N2 reduction step, the multimetallic species involved are usually not well defined, and further transformation of N2-binding complexes to achieve N-H or N-C bond formation is rare...
July 19, 2017: Nature
https://www.readbyqxmd.com/read/28726712/constructed-wetland-integrated-microbial-fuel-cell-system-looking-back-moving-forward
#13
Yae Wang, Yaqian Zhao, Lei Xu, Wenke Wang, Liam Doherty, Cheng Tang, Baiming Ren, Jinhui Zhao
In the last 10 years, the microbial fuel cell (MFC) has been extensively studied worldwide to extract energy from wastewater via electricity generation. More recently, a merged technique of embedding MFC into a constructed wetland (CW) has been developed and appears to be increasingly investigated. The driving force to integrate these two technologies lies in the fact that CWs naturally possess a redox gradient (depending on flow direction and wetland depth), which is required by MFCs as anaerobic anode and aerobic cathode chambers...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28726382/interparticle-reactions-an-emerging-direction-in-nanomaterials-chemistry
#14
K R Krishnadas, Ananya Baksi, Atanu Ghosh, Ganapati Natarajan, Anirban Som, Thalappil Pradeep
Nanoparticles exhibit a rich variety in terms of structure, composition, and properties. However, reactions between them remain largely unexplored. In this Account, we discuss an emerging aspect of nanomaterials chemistry, namely, interparticle reactions in solution phase, similar to reactions between molecules, involving atomically precise noble metal clusters. A brief historical account of the developments, starting from the bare, gas phase clusters, which led to the synthesis of atomically precise monolayer protected clusters in solution, is presented first...
July 20, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28726352/computational-design-of-a-specific-heavy-chain-%C3%AE%C2%BA-light-chain-interface-for-expressing-fully-igg-bispecific-antibodies
#15
K J Froning, A Leaver-Fay, X Wu, S Phan, L Gao, F Huang, A Pustilnik, M Bacica, K Houlihan, Q Chai, J R Fitchett, J Hendle, B Kuhlman, S J Demarest
The use of bispecific antibodies (BsAbs) to treat human diseases is on the rise. Increasingly complex and powerful therapeutic mechanisms made possible by BsAbs are being described in the literature and are spurring innovation of novel BsAb formats and methods for their production. The long-lived in vivo pharmacokinetics, optimal biophysical properties and potential effector functions of natural IgG monoclonal (and monospecific) antibodies has resulted in a push to generate fully IgG BsAb formats with the same quaternary structure as monoclonal IgGs...
July 20, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28726228/microwave-irradiation-and-citric-acid-assisted-seed-germination-and-phytoextraction-of-nickel-ni-by-brassica-napus-l-morpho-physiological-and-biochemical-alterations-under-ni-stress
#16
Mujahid Farid, Shafaqat Ali, Muhammad Rizwan, Rashid Saeed, Hafiz Muhammad Tauqeer, Rasham Sallah-Ud-Din, Ahmed Azam, Nighat Raza
The complex bio-geochemistry of soil allows pollutant to persist for a longer period of time which further decreased the fertility and natural composition of land. Nickel, an inorganic pollutant, coming from a wide range of industrial and manufacturing units possesses serious threat to soil degradation and crop productivity around the world. The present study was carried to evaluate the combined role of microwave irradiation (MR) and citric acid (CA) on the phytoextraction potential of Brassica napus L. under Ni stress...
July 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28725990/molecular-characterization-of-the-indigenous-stingless-bees-tetragonula-spp-complex-using-issr-marker-from-southern-peninsular-india
#17
P P Nayak, J Prakash
India is a country bestowed enormously with stingless bees, but genetic information about them is extremely minimal. This study focused to tap the geographic allocation, genetic variability, and differentiation among Tetragonula species complexes from natural and semi-urban habitats. Genetic analyses were assessed among 36 contrasting genotypes utilizing 20 ISSR primers. The dual combination exquisitely and productively amplified 245 DNA fragments at the loci, of which 240 bands were polymorphic (97.95%). Low to moderate level of genetic differentiation was detected from different estimators (Ht 0...
July 19, 2017: Neotropical Entomology
https://www.readbyqxmd.com/read/28725914/vascular-complications-in-diabetes-old-messages-new-thoughts
#18
REVIEW
Josephine M Forbes, Amelia K Fotheringham
In parallel with the growing diabetes pandemic, there is an increasing burden of micro- and macrovascular complications, occurring in the majority of patients. The identification of a number of synergistic accelerators of disease, providing therapeutic pathways, has stabilised the incidence of complications in most western nations. However, the primary instigators of diabetic complications and, thus, prevention strategies, remain elusive. This has necessitated a refocus on natural history studies, where tissue and plasma samples are sequentially taken to determine when and how disease initiates...
July 19, 2017: Diabetologia
https://www.readbyqxmd.com/read/28725904/cellular-antioxidant-methylglyoxal-trapping-and-anti-inflammatory-activities-of-cocoa-tea-camellia-ptilophylla-chang
#19
Xiong Gao, Xiaorong Lin, Xiaofei Li, Yuanyuan Zhang, Zhongzheng Chen, Bin Li
Cocoa tea (Camellia ptilophylla Chang) is a naturally low caffeine-containing but gallocatechin gallate (GCG)-rich tea cultivar, though its biological activities have not been extensively explored. Herein, we evaluated the in vitro cellular antioxidant, methylglyoxal trapping, and anti-inflammatory activities of water extract of green tea from cocoa tea (CWE) and Yunnan Daye tea (Camellia sinensis) (YWE), and their predominant bioactive components GCG and epigallocatechin gallate (EGCG) for comparative purposes...
July 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28725632/medicinal-importance-pharmacological-activities-and-analytical-aspects-of-hispidulin-a-concise-report
#20
REVIEW
Kanika Patel, Dinesh Kumar Patel
Herbal medicines have been played an important role in the human civilization since very ancient time as a food, cloth, medicine and other aspects. Some of the important drugs in the modern medicine were derived from the natural sources such as aspirin, digitalis, quinine, vincristine, vinblastine etc. Hispidulin (4', 5, 7-trihydroxy-6-methoxyflavone) is a flavones derivative found in plant such as Grindelia argentina, Arrabidaea chica, Saussurea involucrate, Crossostephium chinense, Artemisia and Salvia species...
July 2017: Journal of Traditional and Complementary Medicine
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