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JOURNAL ARTICLE
Julia H Kolodziej, Philip C Spinella, Joshua B Brown, Liling Lu, Cassandra D Josephson, Julie C Leonard, Christine M Leeper
BACKGROUND: Recent data suggest female sex imparts a survival benefit after trauma in adults. The independent associations between patient sex and age with outcomes have not been examined in children with life-threatening hemorrhage (LTH) from all etiologies. STUDY DESIGN AND METHODS: In a secondary analysis of a multicenter prospective observational study of children with LTH, Massive Transfusion in Children (MATIC), we analyzed if patient sex and age were associated with differences in severity of illness, therapies, and outcomes...
March 21, 2024: Transfusion
#22
JOURNAL ARTICLE
Josephine McCullagh
No abstract text is available yet for this article.
March 21, 2024: Transfusion Medicine
#23
JOURNAL ARTICLE
Jun Wang, Jun Chen, Kunpeng Liu, Hua Zhang, Yue Wei, Libin Suo, Shuang Lan, Yanzhen Wang, Chenghua Luo, Lan Yao
OBJECTIVE: Given high risks of major bleeding during retroperitoneal sarcoma(RPS) surgeries, severe complications and deaths are common to see perioperatively. Thus, effective anesthetic management is the key point to ensuring the safety of patients. This study aimed to introduce anesthesia management and mortalities in RPS patients receiving massive blood transfusions during surgeries. METHODS: Records of RPS surgeries under general anesthesia from January 2016 through December 2021 were retrospectively retrieved from our database...
2024: Frontiers in Oncology
#24
REVIEW
Anna Maeser, Malgorzata Biernacka-Zielinska, Elzbieta Smolewska
Macrophage activation syndrome (MAS) is one of the most severe complications of systemic juvenile idiopathic arthritis (sJIA). Around 10% of patients with sJIA exhibit systemic symptoms accompanied by macrophage activation syndrome (MAS), but it may occur subclinically in another 30-40%. In this article, we present a case of a 3-year-old girl diagnosed with sever MAS as an onset of sJIA complicated by disseminated intravascular coagulation (DIC). First symptoms of sJIA were observed about 5 months before setting the diagnose, and it was resembling urticaria...
March 19, 2024: Rheumatology International
#25
JOURNAL ARTICLE
Skye Clayton, Christine M Leeper, Mark H Yazer, Philip C Spinella
BACKGROUND: Low-titer group O whole blood (LTOWB) use is increasing due to data suggesting improved outcomes and safety. One barrier to use is low availability of RhD-negative LTOWB. This survey examined US hospital policies regarding the selection of RhD type of blood products in bleeding emergencies. STUDY DESIGN AND METHODS: A web-based survey of blood bank directors was conducted to determine their hospital's RhD-type selection policies for blood issued for massive bleeding...
March 19, 2024: Transfusion
#26
JOURNAL ARTICLE
Steven C Mehl, Adam M Vogel, Amy E Glasgow, Suzanne Moody, Meera Kotagal, Regan F Williams, Mark L Kayton, Emily C Alberto, Randall S Burd, Thomas J Schroeppel, Joanne E Baerg, Amanda Munoz, William B Rothstein, Laura A Boomer, Eric M Campion, Caitlin Robinson, Rachel M Nygaard, Chad J Richardson, Denise I Garcia, Christian J Streck, Michaela Gaffley, John K Petty, Cynthia Greenwell, Samir Pandya, Alicia M Waters, Robert T Russell, Brian K Yorkgitis, Jennifer Mull, Jeffrey Pence, Matthew T Santore, Taleen A MacArthur, Denise B Klinkner, Shawn D Safford, Tanya Trevilian, Megan Cunningham, Christa Black, Jessica Rea, Ryan G Spurrier, Aaron R Jensen, Bethany J Farr, David P Mooney, Bavana Ketha, Melvin S Dassinger, Anna Goldenberg-Sandau, Janika San Roman, Todd M Jenkins, Richard A Falcone, Stephanie F Polites
BACKGROUND: The benefit of targeting high ratio fresh frozen plasma (FFP):red blood cell (RBC) transfusion in pediatric trauma resuscitation is unclear as existing studies are limited to patients who retrospectively met criteria for massive transfusion. The purpose of this study is to evaluate the use of high ratio FFP:RBC transfusion and the association with outcomes in children presenting in shock. METHODS: A post-hoc analysis of a 24-institution prospective observational study (4/2018-9/2019) of injured children <18 years with elevated age-adjusted shock index was performed...
March 18, 2024: Journal of Trauma and Acute Care Surgery
#27
JOURNAL ARTICLE
K Kaushik, M J H Wermer, E S van Etten
BACKGROUND AND PURPOSE: Patients who underwent red blood cell (RBC) transfusion from donors who later developed multiple spontaneous intracerebral hemorrhages (ICHs) have recently been identified to have increased risk of ICH themselves. This increased risk of ICH was hypothesized to be related to iatrogenic cerebral amyloid angiopathy (iCAA) transmission. Two cases are presented who had RBC transfusion as an infant and presented with CAA at a relatively young age decades later. METHOD: Cases were identified by prospectively asking all patients at our CAA outpatient clinic (November 2023 to January 2024) about a medical history with RBC transfusion or history with a high likelihood for RBC transfusion (e...
March 18, 2024: European Journal of Neurology
#28
REVIEW
Chantal C Mercier Laporte, Brittany Brown, Trevor J Wilke, Cale A Kassel
Liver transplantation continues to provide life-saving treatment for patients with end-stage liver disease. Advances in the field of transplant anesthesia continue to support the care of more complex patients. The use of extracorporeal membrane oxygenation has been described in critical care settings and cardiac surgery but may be a valuable option for specific conditions for patients undergoing liver transplantation. Changes to the allocation process for liver grafts now focus on acuity circles to reduce regional disparities...
February 24, 2024: Journal of Cardiothoracic and Vascular Anesthesia
#29
JOURNAL ARTICLE
Praneetha Mude, Monalisa Pradhan, Anuj Tiwari, Tapas Kanti Parida, Manoj Kumar Nayak, Arun Kumar Sekar, Suvendu Purkait, Usha Devi
A term neonate with history of ventriculomegaly in the fetal period was diagnosed with a central nervous system tumour after radiological investigations. It was confirmed as an immature teratoma after histopathological examination. He underwent left frontal craniotomy with tumour excision. Intraoperatively, massive haemorrhage (venous bleed) occurred due to the high vascularity of the tumour and led to haemodynamic instability. A massive transfusion protocol was initiated. Despite multiple transfusions and shock management, he succumbed at 2 weeks of life...
March 15, 2024: BMJ Case Reports
#30
REVIEW
Khildan Miftahul Firdaus, Lucky Andriyanto, Adil Jihad Muhammad, Tatang Bisri
Craniosynostosis is a congenital condition characterized by the premature closure of one or more sutures in the skull after birth, often necessitating urgent surgical intervention. Nevertheless, cranial vault reconstruction surgery can cause rapid and massive blood loss. This procedure requires a blood transfusion, which entails potential hazards. In addition, the hemostatic system in children differs significantly from that in adults, resulting in increased bleeding during surgical procedures. We conducted a comprehensive literature review in the PubMed, Scopus, and Web of Science databases, referring to their inception for studies on the use of tranexamic acid in pediatric craniosynostosis surgery...
March 14, 2024: Cleft Palate-craniofacial Journal
#31
JOURNAL ARTICLE
Jongchan Lee, Sujung Park, Jae Geun Lee, Sungji Choo, Bon-Nyeo Koo
BACKGROUND: Liver transplantation (LT) may be associated with massive blood loss and the need for allogeneic blood transfusion. Intraoperative blood salvage autotransfusion (IBSA) can reduce the need for allogeneic blood transfusion. This study aimed to investigate the effectiveness of blood salvage in LT. METHODS: Among 355 adult patients who underwent elective living-donor LT between January 1, 2019, and December 31, 2022, 59 recipients without advanced hepatocellular carcinoma received IBSA using Cell Saver (CS group)...
March 12, 2024: Korean Journal of Anesthesiology
#32
JOURNAL ARTICLE
Kristen Spoor, John David Cull, Banan W Otaibi, Joshua P Hazelton, John Chipko, Jessica Reynolds, Sam Fugate, Claire Pederson, Linda B Zier, Lewis E Jacobson, Jamie M Williams, Thomas S Easterday, Saskya Byerly, Caleb Mentzer, Edward Hawke, Daniel C Cullinane, Julianne B Ontengco, Nikolay Bugaev, Madison LeClair, Pascal Udekwu, Cooper Josephs, Matthew Noorbaksh, James Babowice, Catherine Garrison Velopulos, Shane Urban, Anna Goldenberg, Gaby Ghobrial, John M Pickering, Steven D Quarfordt, Alia F Aunchman, Aimee K LaRiccia, Chance Spalding, Richard D Catalano, Jordan E Basham, Philip M Edmundson, Jeffry Nahmias, Erika Tay, Scott H Norwood, Katelyn Meadows, Yee Wong, Claire Hardman
OBJECTIVES: There is little evidence guiding the management of grade I-II traumatic splenic injuries with contrast blush (CB). We aimed to analyze the failure rate of nonoperative management (NOM) of grade I-II splenic injuries with CB in hemodynamically stable patients. METHODS: A multicenter, retrospective cohort study examining all grade I-II splenic injuries with CB was performed at 21 institutions from January 1, 2014, to October 31, 2019. Patients >18 years old with grade I or II splenic injury due to blunt trauma with CB on CT were included...
2024: Trauma Surgery & Acute Care Open
#33
Kristina M Pagano, Alexander A Fokin, Michael Parra, Ivan Puente
Aortoesophageal fistula is rare and typically presents itself to the emergency department as Chiari's Triad of mid-thoracic pain, sentinel arterial hemorrhage, and exsanguination after a symptom-free interval. However, fatal bleeding may be the first and last presentation of an aortoesophageal fistula. When a patient experiences massive hematemesis without witnesses, EMS may assume that bleed is of a traumatic mechanism. We present a case of a 59-year-old male with no previous medical history who was transported to a trauma center unconscious and with massive bleeding of unknown origin...
March 2024: Journal of Surgical Case Reports
#34
JOURNAL ARTICLE
Martin F Bjurström, Ylva C Linder, Jens Kjeldsen-Kragh, Jesper Bengtsson, Thomas Kander
BACKGROUND: Randomized controlled trials relatively consistently show that restrictive red blood cell (RBC) transfusion strategies are safe and associated with similar outcomes compared to liberal transfusion strategies in critically ill patients. Based on these data, the general threshold for RBC transfusion was changed to 70 g/L at a 9-bed tertiary level intensive care unit in September 2020. Implementation measures included lectures, webinars and feedback during clinical practice...
March 7, 2024: Acta Anaesthesiologica Scandinavica
#35
REVIEW
Jan-Michael Van Gent, Thomas W Clements, Bryan A Cotton
Start balanced resuscitation early (pre-hospital if possible), either in the form of whole blood or 1:1:1 ratio. Minimize resuscitation with crystalloid to minimize patient morbidity and mortality. Trauma-induced coagulopathy can be largely avoided with the use of balanced resuscitation, permissive hypotension, and minimized time to hemostasis. Using protocolized "triggers" for massive and ultramassive transfusion will assist in minimizing delays in transfusion of products, achieving balanced ratios, and avoiding trauma induced coagulopathy...
April 2024: Surgical Clinics of North America
#36
JOURNAL ARTICLE
John C Alverdy, Ann Polcari, Andrew Benjamin
Post-injury infection continues to plague trauma and emergency surgery patients fortunate enough to survive the initial injury. Rapid response systems, massive transfusion protocols, the development of level 1 trauma centers, etc., have improved the outcome for millions of patients worldwide. Yet despite this excellent initial care, patients still remain vulnerable to post-injury infections that can result in organ failure, prolonged critical illness and even death. While risk factors have been identified (degree of injury, blood loss, time to definitive care, immunocompromise, etc...
March 4, 2024: Journal of Trauma and Acute Care Surgery
#37
JOURNAL ARTICLE
Hyojeong Kwon, Chang Hwan Sohn, Sang-Min Kim, Youn-Jung Kim, Seung Mok Ryoo, Shin Ahn, Dong-Woo Seo, Won Young Kim
BACKGROUND The modified shock index (MSI) is calculated as the ratio of heart rate (HR) to mean arterial pressure (MAP) and has been used to predict the need for massive transfusion (MT) in trauma patients. This retrospective study from a single center aimed to compare the MSI with the traditional shock index (SI) to predict the need for MT in 612 women diagnosed with primary postpartum hemorrhage (PPH) at the Emergency Department (ED) between January 2004 and August 2023. MATERIAL AND METHODS The patients were divided into the MT group and the non-MT group...
March 4, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
#38
JOURNAL ARTICLE
Xiao-Xiao Lu, Yi Lu, Lin Yang, Yang-Yang Ma, Huan-Huan Wang
The patient was a male infant, born full-term, admitted to the hospital at 28 days of age due to jaundice for 20 days and abdominal distension for 15 days. The patient developed symptoms of jaundice, hepatosplenomegaly, massive ascites, and progressively worsening liver function leading to liver failure, severe coagulation disorders, and thrombocytopenia one week after birth. Various treatments were administered, including anti-infection therapy, fluid restriction, use of diuretics, use of hepatoprotective and choleretic agents, intermittent paracentesis, blood exchange, and intravenous immunoglobulin, albumin, and plasma transfusions...
February 15, 2024: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
#39
JOURNAL ARTICLE
Yosuke Namba, Tsuyoshi Kobayashi, Shintaro Kuroda, Masakazu Hashimoto, Daisuke Takei, Sotaro Fukuhara, Ko Oshita, Keiso Matsubara, Naruhiko Honmyo, Ryosuke Nakano, Hiroshi Sakai, Hiroyuki Tahara, Masahiro Ohira, Kentaro Ide, Hideki Ohdan
BACKGROUND: In patients with chronic liver diseases such as cirrhosis, massive ascites after hepatic resection is the cause of prolonged hospitalization and worsening prognosis. Recently, the efficacy of tolvaptan in refractory ascites has been reported; however, there are no reports on the efficacy or safety of tolvaptan for refractory ascites after hepatic resection. This study aims to evaluate the efficacy of early administration of tolvaptan in patients with refractory ascites after hepatic resection...
March 2024: International journal of surgery protocols
#40
JOURNAL ARTICLE
Nadia M Keltner, Melissa M Cushing, Thorsten Haas, Philip C Spinella
BACKGROUND: Hemorrhage is a leading cause of preventable death in trauma, cardiac surgery, liver transplant, and childbirth. While emphasis on protocolization and ratio of blood product transfusion improves ability to treat hemorrhage rapidly, tools to facilitate understanding of the overall content of a specific transfusion strategy are lacking. Medical modeling can provide insights into where deficits in treatment could arise and key areas for clinical study. By using a transfusion model to gain insight into the aggregate content of massive transfusion protocols (MTPs), clinicians can optimize protocols and create opportunities for future studies of precision transfusion medicine in hemorrhage treatment...
March 3, 2024: Transfusion
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