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Haemoglobin A1c

O May, C B Graversen, M Ø Johansen, H Arildsen
Cardiovascular autonomic neuropathy (CAN) is a well known prognostic marker in diabetes. A large angle between the QRS- and the T-wave vector (QRS-T angle) in the electrocardiogram (ECG) has recently been introduced as another marker of poor prognosis. AIM: To assess and compare the long-term predictive power of the frontal plane QRS-T angle with CAN in people with diabetes. METHODS: In 1992-93 people with diabetes in the municipality of Horsens, Denmark, were identified by the prescription method andan age and gender stratified sample of 240 individuals with diabetes were randomly selected...
May 15, 2018: Diabetes Research and Clinical Practice
Anatolie Baltatescu, Elio Striglia, Marina Trento, Aurora Mazzeo, Franco Cavallo, Lorena Charrier, Massimo Porta
PURPOSE: Detection of microaneurysms and/or microhaemorrhages near the fovea when screening for diabetic retinopathy poses a problem because referral to retinal specialists may alarm patients and unnecessarily burden ophthalmologists. METHODS: Six-month prospective study of patients found to have minimal red lesions within one disc diameter of the fovea when screened for diabetic retinopathy. Two 45° digital photographs, one centred on the macula and the other nasal including the optic disc, were taken for each eye...
May 1, 2018: Diabetes & Vascular Disease Research
Wei Hai Deng, Morten Lindberg, Ole Petter Hjelle, Asgeir Mamen, Per Morten Fredriksen
AIMS: The main aim of the present study was to investigate the clustering of risk factors for cardiovascular diseases and metabolic syndrome in a large, healthy representative Norwegian child population. METHODS: From a population of 2817, parents of 2297 children agreed to participate. Values of waist circumference (WC), total cholesterol (TC), high-density lipoprotein (HDL), systolic blood pressure (sysBP), haemoglobin-A1c (HbA1c) and Andersen aerobic fitness test were used to test clustering of cardiometabolic risk factors in this sample...
May 2018: Scandinavian Journal of Public Health
Shota Hamada, Martin C Gulliford
OBJECTIVES: This study aimed to evaluate the effectiveness of multiple risk factor control (MRFC) at reducing mortality and cardiovascular events in diabetes and chronic kidney disease (CKD) in clinical practice. DESIGN: Population-based cohort study. SETTING: Primary care database in the UK, linked with inpatient and mortality data. PARTICIPANTS: Participants aged 40-79 years with type 2 diabetes and valid serum creatinine measurements, including 11 431 participants with CKD (estimated glomerular filtration rate: eGFR 15-59 mL/min/1...
May 8, 2018: BMJ Open
J Y Cui, R R Zhou, S Han, T S Wang, L Q Wang, X H Xie
WHAT IS KNOWN AND OBJECTIVE: Statins are the cornerstone of primary and secondary prevention of cardiovascular diseases (CVDs) and are effective for the prevention of vascular events in diabetic patients. Diabetes mellitus is an important risk factor for CVDs .The majority of patients with diabetes mellitus benefits from statin therapy. According to the recent clinical guidelines of the American College of Cardiology and the American Heart Association, moderate-intensity or high-intensity statin therapy should be used as the primary prevention for individuals with diabetes mellitus, aged between 40 and 75 years and with low-density lipoprotein cholesterol (LDL-C) from 70 to 189 mg/dL...
May 7, 2018: Journal of Clinical Pharmacy and Therapeutics
Sujit D Rathod, Amelia C Crampin, Crispin Musicha, Ndoliwe Kayuni, Louis Banda, Jacqueline Saul, Estelle McLean, Keith Branson, Shabbar Jaffar, Moffat J Nyirenda
OBJECTIVES: To examine the accuracy of glycated haemoglobin A1c (HbA1c ) in detecting type 2 diabetes and impaired fasting glucose among adults living in Malawi. DESIGN: A diagnostic validation study of HbA1c . Fasting plasma glucose (FPG) ≥7.0 mmol/L was the reference standard for type 2 diabetes, and FPG between 6.1 and 6.9 mmol/L as impaired fasting glucose. PARTICIPANTS: 3645 adults (of whom 63% were women) recruited from two demographic surveillance study sites in urban and rural Malawi...
May 5, 2018: BMJ Open
Carrie A Karvonen-Gutierrez, Qing Peng, Mark Peterson, Kate Duchowny, Bin Nan, Sioban Harlow
Background: skeletal muscle is the primary site of glucose uptake, yet the impact of age-related changes in muscle strength on diabetes risk is unknown. Methods: four hundred and twenty-four participants (60% Black, 40% White) from the Michigan site of the Study of Women's Health Across the Nation contributed annual grip strength measures and were followed from 1996 to 2012 to identify incident cases of diabetes. Diabetes was defined as self-reported physician-diagnosed diabetes, use of anti-diabetic medications or measured fasting glucose ≥126 mg/dl or haemoglobin A1c > 6...
May 3, 2018: Age and Ageing
Chi-Jung Huang, Wei-Ting Wang, Shih-Hsien Sung, Chen-Huan Chen, Gregory Yh Lip, Hao-Min Cheng, Chern-En Chiang
AIM: To investigate the effects of blood glucose control with antihyperglycemic agents with minimal hypoglycemia risk on cardiovascular outcomes in patients with type 2 diabetes (T2D). MATERIALS AND METHODS: Randomized controlled trials (RCTs) comparing the relative efficacy and safety of antidiabetic drugs with less hypoglycemia risk were comprehensively searched in MEDLINE, Embase, and the Cochrane Library up to January 27, 2018. Mixed-effects meta-regression analysis was conducted to explore the relationship between haemoglobin A1c (HbA1c) reduction and the risk of major adverse cardiovascular events (MACE), myocardial infarction, stroke, cardiovascular death, all-cause death, and hospitalization for heart failure...
May 2, 2018: Diabetes, Obesity & Metabolism
Imad R Musa, Mohanned O N Ahmed, Elsanousi Ibrahim Sabir, Ibrahim F Alsheneber, Elsayed M E Ibrahim, Gussay Badawi Mohamed, Rasha Elamin Awadallah, Tarig Abbas, Gasim Ibrahim Gasim
OBJECTIVES: A prospective study was conducted at the Armed Forces Hospital, Dhahran, Saudi Arabia, between January 2015 and December 2016 to identify the risk factors associated with amputation among diabetic foot ulcers DFUs patients. RESULTS: In total, 82 patients were recruited. Fifty-five of the patients were males (67.07%), the mean (SD) age of the participants was 60 (± 11.4) years, the mean duration of diabetes was 8.5 (± 3.7) years, and the mean haemoglobin A1c was 4...
April 27, 2018: BMC Research Notes
I L Oikonomidis, T K Tsouloufi, N Soubasis, M Kritsepi-Konstantinou
Haemoglobin A1c (HbA1c), the major fraction of glycated haemoglobin, is widely used for the diagnosis and monitoring of diabetes mellitus in human beings. However, there is a paucity of literature on the most reliable methods available for measurement of canine HbA1c. The aim of this study was to validate a new automated capillary electrophoresis assay for canine HbA1c, to generate a reference interval and to assess the overlap performance of the assay for the diagnosis of diabetes mellitus. Eighty-three blood samples treated with EDTA were included in the study, comprising 63 from healthy dogs and 20 from diabetic dogs...
April 2018: Veterinary Journal
Vincent DeGennaro, Stuart Malcolm, Lindsay Crompton, Krishna Vaddiparti, Lazarus K Mramba, Catherine Striley, Linda Cottler, Kellee Taylor, Robert Leverence
OBJECTIVE: To estimate the prevalence of hypertension, diabetes and chronic kidney disease and their risk factors in a rural and urban region of Haiti. SETTING AND PARTICIPANTS: Community health workers enumerated 2648 households (909 rural and 1739 urban) via a multistage cluster random sampling method from July 2015 to May 2016, completed 705 rural and 1419 urban assessments for adults aged 25-65 years. OUTCOME MEASURES: We performed a WHO STEPS based questionnaire, measured two blood pressure values, weight, height, abdominal circumference and point of care test finger stick blood sample for haemoglobin A1c, creatinine and cholesterol (total, high density lipoprotein (HDL) and triglycerides)...
April 20, 2018: BMJ Open
F Tillman, J Kim
WHAT IS KNOWN AND OBJECTIVE: A variety of medication classes are available for diabetes; however, treatment options become limited due to adverse effect profiles and cost. Current diabetes guidelines include agents not originally developed for diabetes treatment, bromocriptine and colesevelam. COMMENT: Other non-diabetes medications demonstrating haemoglobin A1c lowering, including agents for weight loss, depression, anaemia and coronary artery disease, are described in this review article...
April 19, 2018: Journal of Clinical Pharmacy and Therapeutics
Yufei Wang, Wei Peng, Junling Tang, Lu Dong, Chengchen Gu, Xin Zhang, Jian Zhou, Weiping Jia
Introduction: A real world clinical study was designed and conducted to evaluate the performance of a novel point-of-care device for determination of glycated haemoglobin A1c (HbA1c ), A1C EZ 2.0, in daily clinical practice. Materials and methods: Five hundred and fourteen subjects were included in this study, and divided into three groups. HbA1c was measured by A1C EZ 2.0 and three different high performance liquid chromatography (HPLC) devices: Bio-Rad Variant II Turbo, Tosoh HLC-723 G8 and Premier Hb9210 separately...
June 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
Sascha Pilemann-Lyberg, Tine Willum Hansen, Frederik Persson, Simone Theilade, Tarunveer Singh Ahluwalia, Jan Frystyk, Peter Rossing
Background: To examine the association between plasma uric acid (UA) and the presence of diabetic complications including diabetic nephropathy and cardiovascular risk factors in patients with type 1 diabetes. Methods: This study, which is cross-sectional in design, included 676 Caucasian type 1 diabetes patients from the Steno Diabetes Center Copenhagen. Participants with UA within the three lowest sex-specific quartiles were compared with participants with levels in the highest quartile...
April 11, 2018: Nephrology, Dialysis, Transplantation
Sanbao Chai, Baoting Yao, Lin Xu, Danyang Wang, Jianbin Sun, Ning Yuan, Xiaomei Zhang, Linong Ji
OBJECTIVE: The purpose of this study was to evaluate the efficacy of self-management education on psychological outcomes and glycemic control in type 2 diabetes mellitus. METHODS: Patients were randomly assigned to education group and control group. Education group received professional education and control group received routine outpatient education. RESULTS: A total of 118 patients were randomly assigned to two groups (education group, n = 63; control group, n = 55)...
March 30, 2018: Patient Education and Counseling
Marzieh Niknami, Ali Mirbalouchzehi, Iraj Zareban, Elahibakhsh Kalkalinia, Gasem Rikhtgarha, Hassan Hosseinzadeh
This study explores the potential association of health literacy with type 2 diabetes mellitus (T2DM) self-management and clinical outcomes in the primary care setting of Iran. A total of 347 T2DM patients, mostly female (52.4%), 50 years old or younger (63.1%), unemployed (53.6%) and rural residents (55.6%) participated in this study. Most of the respondents had type 2 diabetes mellitus (T2DM) for 2-5 years (63.1%) and did not receive any T2DM education (52.2%). Approximately 19.0% were hospitalised due to uncontrolled T2DM...
April 6, 2018: Australian Journal of Primary Health
Neuza Mendes, Rogério Tavares Ribeiro, Fátima Serrano
Strict glycaemic management is the cornerstone of metabolic control in gestational diabetes mellitus (GDM). Current monitoring standards involve self-monitoring plasma glucose (SMBG) and haemoglobin A1c (HbA1c). However, both have important limitations. SMBG only reflects instantaneous blood glucose and the inconvenience of self-collecting blood frequently results in poor compliance. HbA1c provides information on blood glucose levels from the previous 2 to 3 months and it is influenced by iron-deficient states, common during pregnancy...
April 5, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Clemens Höbaus, Gerfried Pesau, Carsten Thilo Herz, Thomas Wrba, Renate Koppensteiner, Gerit-Holger Schernthaner
Survival of peripheral arterial disease (PAD) patients increased over the last decade due to increased use of secondary preventive medication and rapid revascularization of PAD patients. Angiogenetic markers such as vascular endothelial growth factor (VEGF), angiopoietin-2 (Ang-2) and its receptor Tie-2 might be useful markers to assess the residual risk for mortality in PAD patients. The aim of this study was to evaluate angiogenetic markers for the prediction of mortality in a PAD cohort. For this purpose, 366 patients (mean age: 69 ± 10 years) with PAD Fontaine stage I or II were included and followed up over a 5-year study period...
April 2018: Thrombosis and Haemostasis
Ali Kordzadeh, Bruno Lorenzi, Muhammad A Hanif, Alexandros Charalabopoulos
BACKGROUND: Endovascular left gastric artery (LGA) embolisation has gained significant attention in the treatment of obesity/morbid obesity and reduction of ghrelin. The objective of this systematic review is to evaluate the recent literature, strengths, limitations and practical aspects of this new procedure in combination with its physiological and anatomical paradigm. METHODS: A systematic electronic search of literature from 1966 to June 2017 in Medline, CINHAL, Embase, Scopus and Cochrane library in English language and adult subjects was conducted...
April 3, 2018: Obesity Surgery
Foo Nian Wong, Kek Heng Chua, Jin Ai Mary Anne Tan, Chew Ming Wong, Umah Rani Kuppusamy
Background: Chronic kidney disease (CKD) is characterised by long-term kidney damage and renal function decline. Diabetic CKD is the principal subtype of kidney disease in Malaysia and is associated with oxidative stress which plays an important role in development and progression of the disease. Glycaemic control slows down the progression of diabetic complications, including diabetic CKD. However, the implication of glycaemic control on enzymatic antioxidants and soluble RAGE (sRAGE) in CKD patients remains elusive...
2018: PeerJ
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