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Haemoglobin A1c

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https://www.readbyqxmd.com/read/28025216/hydroxychloroquine-for-the-prevention-of-recurrent-cardiovascular-events-in-myocardial-infarction-patients-rationale-and-design-of-the-oxi-trial
#1
Otto Hartman, Petri T Kovanen, Jukka Lehtonen, Kari K Eklund, Juha Sinisalo
BACKGROUND: Inflammation of the arterial wall plays a central role in the pathogenesis of atherosclerosis. Among patients with rheumatic diseases, anti-rheumatic medication reduces the incidence of cardiovascular (CV) diseases, but only few studies have addressed their cardioprotective effects on patients with no rheumatic diseases. Hydroxychloroquine (HCQ) is an anti-rheumatic drug commonly used in the treatment of rheumatoid arthritis and systemic lupus erythematosus. In addition to its anti-inflammatory properties, HCQ reduces cholesterol levels and the risk of type II diabetes, and has also anti-platelet effects...
November 8, 2016: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28011309/the-effect-of-prolonged-glucosamine-usage-on-hba1c-levels-and-new-onset-diabetes-mellitus-in-overweight-and-obese-middle-aged-women
#2
Y M M Gommans, J Runhaar, M L Jacobs, S M A Bierma-Zeinstra
OBJECTIVE: The aim of the present study was to evaluate the effect of a 2.5 year glucosamine sulphate intervention on haemoglobin A1c (HbA1c) levels and the incidence of new-onset diabetes mellitus over 6.5 years in middle-aged women with a BMI ≥27 kg/m(2). METHODS: In total, 407 women were randomized into either oral crystalline glucosamine sulphate or placebo. At baseline, 1 year, 2.5 years and 6.5 years a blood sample for the HbA1c level was drawn and a questionnaires were taken...
December 20, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27981620/comparison-of-clinical-and-radiographic-status-around-immediately-loaded-versus-conventional-loaded-implants-placed-in-patients-with-type-2-diabetes-12-and-24-month-follow-up-results
#3
M D Al Amri, A M Alfarraj Aldosari, S S Al-Johany, A M Al Baker, M Q Al Rifaiy, A A Al-Kheraif
There are no studies that have compared the clinical and radiographic status around immediately loaded (IL) and conventional loaded (CL) implants placed in patients with type 2 diabetes mellitus (T2DM). The aim was to compare the clinical and radiographic status around IL and CL implants placed in T2DM patients. One hundred and eight diabetic patients [55 with IL implants (Group 1) and 53 with CL implants (Group 2)] were included in this cross-sectional study. All implants were placed in healed sites in the maxillary and mandibular premolar and molar regions and supported single restorations...
December 15, 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27977404/sensitivity-and-specificity-of-different-methods-for-cystic-fibrosis-related-diabetes-screening-is-the-oral-glucose-tolerance-test-still-the-standard
#4
Catherine Mainguy, Gabriel Bellon, Véronique Delaup, Tiphanie Ginoux, Behrouz Kassai-Koupai, Stéphane Mazur, Muriel Rabilloud, Laurent Remontet, Philippe Reix
BACKGROUND: Cystic fibrosis-related diabetes (CFRD) is a late cystic fibrosis (CF)-associated comorbidity whose prevalence is increasing sharply lifelong. Guidelines for glucose metabolism (GM) monitoring rely on the oral glucose tolerance test (OGTT). However, this test is neither sensitive nor specific. The aim of this study was to compare sensitivity and specificity of different methods for GM monitoring in children and adolescents with CF. METHODS: Continuous glucose monitoring system (CGMS), used as the reference method, was compared with the OGTT, intravenous glucose tolerance test (IGTT), homeostasis model assessment index of insulin resistance (HOMA-IR), homeostasis model assessment index of β-cell function (HOMA-%B) and glycated haemoglobin A1C...
January 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27941053/patient-characteristics-related-to-metabolic-disorders-and-chronic-complications-in-type-2-diabetes-mellitus-patients-hospitalized-at-the-qingdao-endocrine-and-diabetes-hospital-from-2006-to-2012-in-china
#5
Yanhu Dong, Weiguo Gao, Lei Zhang, Jia Wei, Niklas Hammar, Claudia S Cabrera, Xiaoli Wu, Qing Qiao
OBJECTIVE: To study the clinical characteristics related to metabolic disorders and complications in type 2 diabetes mellitus patients hospitalized in the Qingdao Endocrine and Diabetes Hospital from 2006 to 2012 in Qingdao, China. PATIENT POPULATION AND METHODS: Data from 14,289 (51% males) type 2 diabetes mellitus patients hospitalized between 2006 and 2012 were collected and analysed. Information on patients' demographic, anthropometric, laboratory and disease histories were extracted from electronic medical records...
January 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/27930697/early-antenatal-prediction-of-gestational-diabetes-in-obese-women-development-of-prediction-tools-for-targeted-intervention
#6
Sara L White, Debbie A Lawlor, Annette L Briley, Keith M Godfrey, Scott M Nelson, Eugene Oteng-Ntim, Stephen C Robson, Naveed Sattar, Paul T Seed, Matias C Vieira, Paul Welsh, Melissa Whitworth, Lucilla Poston, Dharmintra Pasupathy
All obese women are categorised as being of equally high risk of gestational diabetes (GDM) whereas the majority do not develop the disorder. Lifestyle and pharmacological interventions in unselected obese pregnant women have been unsuccessful in preventing GDM. Our aim was to develop a prediction tool for early identification of obese women at high risk of GDM to facilitate targeted interventions in those most likely to benefit. Clinical and anthropometric data and non-fasting blood samples were obtained at 15+0-18+6 weeks' gestation in 1303 obese pregnant women from UPBEAT, a randomised controlled trial of a behavioural intervention...
2016: PloS One
https://www.readbyqxmd.com/read/27914513/fatty-acid-profile-in-cord-blood-of-neonates-born-to-optimally-controlled-gestational-diabetes-mellitus
#7
Pauline Léveillé, Jean-Luc Ardilouze, Jean-Charles Pasquier, Charles Deacon, Kevin Whittingstall, Mélanie Plourde
OBJECTIVE: To evaluate the fatty acid profile of cord blood phospholipids (PL), cholesteryl esters (CE), triglycerides (TG) and non-esterified fatty acids (NEFA) in neonates born to mothers with gestational diabetes mellitus (GDM) compared to non-diabetic mothers. METHODS: The offspring of 30 pregnant women (15 non-diabetic controls, 15 with diet- or insulin-controlled GDM) were recruited before delivery. Cord blood was collected. After lipid extraction, PL, CE, TG and NEFA were separated by thin layer chromatography and analysed by gas chromatography...
December 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27913444/correlation-of-retinal-arterial-wall-thickness-with-atherosclerosis-predictors-in-type-2-diabetes-without-clinical-retinopathy
#8
Shigeta Arichika, Akihito Uji, Tomoaki Murakami, Kiyoshi Suzuma, Norimoto Gotoh, Nagahisa Yoshimura
AIMS: To evaluate retinal arterial wall thickness (WT) using high-resolution retinal imaging in patients with type 2 diabetes and assess its correlation with risk factors for arteriosclerosis. METHODS: Outer diameter, inner diameter and WT of the retinal artery were measured using adaptive optics scanning laser ophthalmoscopy in 28 patients with type 2 diabetes without clinically apparent diabetic retinopathy and normal volunteers. Laboratory values and intima-media thickness (IMT) in the common carotid artery were measured...
January 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27892613/depressive-symptoms-prediabetes-and-incident-diabetes-in-older-english-adults
#9
Eva Graham, Bonnie Au, Norbert Schmitz
OBJECTIVE: The objective of this study was to assess the risk of diabetes in older adults with elevated depressive symptoms, prediabetes, or both. METHOD: This study included 4129 participants from the English Longitudinal Study of Ageing. Participants were followed from Wave 2 (2004-2005) to Wave 6 (2012-2013). The 8-item Centre for Epidemiologic Studies Depression (CESD) scale was used to measure depressive symptoms in the past week, which were categorized as no/low, mild, or high...
November 28, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27891757/a-randomized-double-blind-phase-iii-study-to-evaluate-efficacy-and-safety-of-once-daily-treatment-of-alogliptin-and-metformin-hydrochloride-in-japanese-patients-with-type-2-diabetes
#10
Kohei Kaku, Shuuji Sumino, Masafumi Katou, Yuya Nishiyama, Yoshinobu Kinugawa
This randomized, double-blind, phase III study evaluated the efficacy and safety of once-daily (q.d.) treatment of alogliptin (25 mg q.d.) alone or with metformin hydrochloride (500 mg q.d. or 250 mg twice daily [b.i.d.]) in Japanese patients with type 2 diabetes. The primary endpoint was change in haemoglobin A1c (HbA1c) from baseline to the end of treatment (week 24). The least-squares mean (LSM) change in HbA1c from baseline (standard error) to the end of treatment (week 24) was 0.16% (0.072) in alogliptin alone, -0...
November 28, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27881363/association-between-prediabetes-and-risk-of-cardiovascular-disease-and-all-cause-mortality-systematic-review-and-meta-analysis
#11
Yuli Huang, Xiaoyan Cai, Weiyi Mai, Meijun Li, Yunzhao Hu
OBJECTIVES:  To evaluate associations between different definitions of prediabetes and the risk of cardiovascular disease and all cause mortality. DESIGN:  Meta-analysis of prospective cohort studies. DATA SOURCES:  Electronic databases (PubMed, Embase, and Google Scholar). SELECTION CRITERIA:  Prospective cohort studies from general populations were included for meta-analysis if they reported adjusted relative risks with 95% confidence intervals for associations between the risk of composite cardiovascular disease, coronary heart disease, stroke, all cause mortality, and prediabetes...
November 23, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27862497/can-follow-up-phone-calls-improve-patients-self-monitoring-of-blood-glucose
#12
Cheryl Brown-Deacon, Terri Brown, Constance Creech, Marilyn McFarland, Anupama Nair, Kevin Whitlow
AIMS AND OBJECTIVES: To evaluate the effectiveness of follow-up phone calls in improving frequency of glucose monitoring over a three month period in two groups of patients with type 2 diabetes with the goal to lower haemoglobin A1C. BACKGROUND: Telephone intervention has been successfully used in improving adherence to diabetes self-management and other chronic disease conditions. DESIGN: A quality improvement study. METHODS: Forty one Type 2 diabetic patients with HA1C ≥7·5% were included in the study...
January 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27835680/benefits-and-harms-of-sodium-glucose-co-transporter-2-inhibitors-in-patients-with-type-2-diabetes-a-systematic-review-and-meta-analysis
#13
Heidi Storgaard, Lise L Gluud, Cathy Bennett, Magnus F Grøndahl, Mikkel B Christensen, Filip K Knop, Tina Vilsbøll
OBJECTIVE: Sodium-glucose co-transporter 2 inhibitors (SGLT2-i) are a novel drug class for the treatment of diabetes. We aimed at describing the maximal benefits and risks associated with SGLT2-i for patients with type 2 diabetes. DESIGN: Systematic review and meta-analysis. DATA SOURCES AND STUDY SELECTION: We included double-blinded, randomised controlled trials (RCTs) evaluating SGLT2-i administered in the highest approved therapeutic doses (canagliflozin 300 mg/day, dapagliflozin 10 mg/day, and empagliflozin 25 mg/day) for ≥12 weeks...
2016: PloS One
https://www.readbyqxmd.com/read/27833048/the-effects-of-intermittent-compared-to-continuous-energy-restriction-on-glycaemic-control-in-type-2-diabetes-a-pragmatic-pilot-trial
#14
S Carter, P M Clifton, J B Keogh
AIMS: Weight loss improves glycaemic control in type 2 diabetes mellitus (T2DM). However, as achieving and maintaining weight loss is difficult, alternative strategies are needed. Our primary aim was to investigate the effects of intermittent energy restriction (IER) compared to continuous energy restriction (CER) on glycated haemoglobin A1c (HbA1c). Secondary aims were to assess effects on weight loss, body composition, medication changes and subjective measures of appetite. Using a 2-day IER method, we expected equal improvements to HbA1c and weight in both groups...
December 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27812376/norepinephrine-transporter-expression-is-inversely-associated-with-glycaemic-indices-a-pilot-study-in-metabolically-diverse-persons-with-overweight-and-obesity
#15
N E Straznicky, L Guo, S J Corcoran, M D Esler, S E Phillips, C I Sari, M T Grima, S Karapanagiotidis, C Y Wong, N Eikelis, J A Mariani, D Kobayashi, J B Dixon, G W Lambert, E A Lambert
OBJECTIVE: The objective of this study was to examine the cross-sectional relationship between the expression of norepinephrine transporter (NET), the protein responsible for neuronal uptake-1, and indices of glycaemia and hyperinsulinaemia, in overweight and obese individuals. METHODS: Thirteen non-medicated, non-smoking subjects, aged 58 ± 1 years (mean ± standard error of the mean), body mass index (BMI) 31.4 ± 1.0 kg m(-2), with wide-ranging plasma glucose and haemoglobin A1c (HbA1c, range 5...
March 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/27812304/a-comparative-evaluation-of-the-analytical-performances-of-capillarys-2-flex-piercing-tosoh-hlc-723-g8-premier-hb9210-and-roche-cobas-c501-tina-quant-gen-2-analyzers-for-hba1c-determination
#16
Xiaobin Wu, Yan Chao, Zemin Wan, Yunxiu Wang, Yan Ma, Peifeng Ke, Xinzhong Wu, Jianhua Xu, Junhua Zhuang, Xianzhang Huang
INTRODUCTION: Haemoglobin A1c (HbA1c) is widely used in the management of diabetes. Therefore, the reliability and comparability among different analytical methods for its detection have become very important. MATERIALS AND METHODS: A comparative evaluation of the analytical performances (precision, linearity, accuracy, method comparison, and interferences including bilirubin, triglyceride, cholesterol, labile HbA1c (LA1c), vitamin C, aspirin, fetal haemoglobin (HbF), and haemoglobin E (Hb E)) were performed on Capillarys 2 Flex Piercing (Capillarys 2FP) (Sebia, France), Tosoh HLC-723 G8 (Tosoh G8) (Tosoh, Japan), Premier Hb9210 (Trinity Biotech, Ireland) and Roche Cobas c501 (Roche c501) (Roche Diagnostics, Germany)...
October 15, 2016: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/27798061/impact-of-glucose-control-on-early-vein-graft-failure-after-coronary-artery-bypass-grafting-one-month-angiographic-results
#17
Shinji Ogawa, Yasuhide Okawa, Koshi Sawada, Yusuke Motoji, Yoshihiro Goto, Arishige Kimura, Mototsugu Tamaki, Yutaka Koyama, Masanori Yamamoto, Toshiaki Otsuka, Takayoshi Kato, Syunsuke Fukaya, Tomohiro Tsunekawa, Hideki Kitamura, Shinji Tomita, Takahiko Suzuki
OBJECTIVES: To identify factors that determine early saphenous vein graft failure (VGF) within 1 month after coronary artery bypass grafting (CABG). METHODS: Seven hundred forty-nine consecutive patients underwent primary isolated CABG with saphenous vein grafts at three Japanese centres from 1 January 2005 to 31 December 2014. According to angiographic findings within 1 month of CABG surgery, 63 patients (8.4%) developed early VGF. We examined the relationships between variables and early VGF by using multivariable logistic regression analysis...
October 20, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27796906/basal-bolus-therapy-in-patients-with-type-2-diabetes-mellitus-in-the-uk-patient-characteristics-treatment-patterns-and-the-effect-of-switching-to-premixed-insulin
#18
Kate van Brunt, Bradley Curtis, Tibor Ivanyi, Elemer Balogh, Corina Chalkiadaki, Sharon MacLachlan, David Neasham, Mireia Raluy-Callado
INTRODUCTION: Increasing emphasis is being placed on insulin use among patients with type 2 diabetes mellitus (T2DM). Basal-bolus (BB) therapy is regarded as the gold standard, but a high frequency of injections and the general complexity of this therapy are seen as barriers in real-world practice. Here we describe the characteristics and treatment patterns of patients with T2DM receiving BB in the UK, with specific focus on those switching to a simplified regimen of premixed insulin...
December 2016: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/27790816/in-hospital-and-1-year-mortality-associated-with-diabetes-in-patients-with-acute-heart-failure-results-from-the-esc-hfa-heart-failure-long-term-registry
#19
Giovanni Targher, Marco Dauriz, Cécile Laroche, Pier Luigi Temporelli, Mahmoud Hassanein, Petar M Seferovic, Jaroslaw Drozdz, Roberto Ferrari, Stephan Anker, Andrew Coats, Gerasimos Filippatos, Maria G Crespo-Leiro, Alexandre Mebazaa, Massimo F Piepoli, Aldo Pietro Maggioni, Luigi Tavazzi
AIMS: The aim of this study was to evaluate the in-hospital and 1-year prognostic impact of diabetes and elevated blood glucose levels at hospital admission in patients with acute heart failure (HF). METHODS AND RESULTS: We studied a multinational cohort of 6926 hospitalized patients with acute HF enrolled in the European Society of Cardiology (ESC) and Heart Failure Association (HFA) Long-Term Registry, of whom 49.4% (n = 3422) had known or previously undiagnosed diabetes (defined as self-reported history, or medication use, or fasting glucose levels ≥7...
October 28, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27790422/p3-fraction-effect-on-hba1c-values-by-hplc
#20
Mrinal Gupta, Mohit Thalquotra, Pragna Rao
INTRODUCTION: The availability of the haemoglobin A1c test has been a major advance in diabetic care and its measurement has become an integral part for the management of diabetes. When glycated haemoglobin (HbA1c) is estimated by High Performance Liquid Chromatography (HPLC), one of the fractions that are eluted is known as "P3" fraction which is labelled as "degenerated haemoglobin". The P3 fraction is not taken into account while estimating HbA1c or HbA values. AIM: To study the effect of P3 on the final reported value of HbA1c by HPLC and the significance of this fraction in the final chromatogram...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
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