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Haemoglobin A1c

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https://www.readbyqxmd.com/read/28780559/doctor-referral-of-overweight-people-to-a-low-energy-treatment-droplet-in-primary-care-using-total-diet-replacement-products-a-protocol-for-a-randomised-controlled-trial
#1
Susan A Jebb, Nerys M Astbury, Sarah Tearne, Alecia Nickless, Paul Aveyard
INTRODUCTION: The global prevalence of obesity has risen significantly in recent decades. There is a pressing need to identify effective interventions to treat established obesity that can be delivered at scale. The aim of the Doctor Referral of Overweight People to a Low-Energy Treatment (DROPLET) study is to determine the clinical effectiveness, feasibility and acceptability of referral to a low-energy total diet replacement programme compared with usual weight management interventions in primary care...
August 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28765426/sodium-glucose-co-transporter-2-inhibitors-successfully-attenuated-seasonal-change-of-glycated-haemoglobin-a1c
#2
Eijiro Yamada, Tsugumichi Saito, Yawara Niijima, Shuichi Okada, Masanobu Yamada
No abstract text is available yet for this article.
July 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28760792/glycated-haemoglobin-a1c-as-a-risk-factor-of-cardiovascular-outcomes-and-all-cause-mortality-in-diabetic-and-non-diabetic-populations-a-systematic-review-and-meta-analysis
#3
Iván Cavero-Redondo, Barbara Peleteiro, Celia Álvarez-Bueno, Fernando Rodriguez-Artalejo, Vicente Martínez-Vizcaíno
OBJECTIVE: To examine the relationship between glycated haemoglobin A1c (HbA1c) levels and the risk of cardiovascular outcomes and all-cause mortality based on data from observational studies and to determine the optimal levels of HbA1c for preventing cardiovascular events and/or mortality in diabetic and non-diabetic populations. REVIEW METHODS: We systematically searched Medline, Embase, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews and Web of Science databases, from inception to July 2016, for observational studies addressing the association of HbA1c levels with mortality and cardiovascular outcomes...
July 31, 2017: BMJ Open
https://www.readbyqxmd.com/read/28750220/effects-of-medicinal-food-plants-on-impaired-glucose-tolerance-a-systematic-review-of-randomized-controlled-trials
#4
REVIEW
A Demmers, H Korthout, F S van Etten-Jamaludin, F Kortekaas, J M Maaskant
BACKGROUND: The objective of this systematic review was to assess available scientific data on the efficacy and safety of medicinal food plants for the treatment of impaired glucose tolerance. METHODS: We included randomized controlled trials (RCTs) with a minimum follow-up period of 6weeks. The diagnosis was determined by fasting plasma glucose values after two-hour oral glucose tolerance testing (OGTT). Two authors independently extracted data and evaluated bias...
June 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28734906/results-from-15years-of-quality-surveillance-for-a-national-indigenous-point-of-care-testing-program-for-diabetes
#5
Mark Shephard, Anne Shephard, Bridgit McAteer, Tamika Regnier, Kristina Barancek
INTRODUCTION: Diabetes is a major health problem for Australia's Aboriginal and Torres Strait Islander peoples. Point-of-care testing for haemoglobin A1c (HbA1c) has been the cornerstone of a long-standing program (QAAMS) to manage glycaemic control in Indigenous people with diabetes and recently, to diagnose diabetes. METHODS: The QAAMS quality management framework includes monthly testing of quality control (QC) and external quality assurance (EQA) samples. Key performance indicators of quality include imprecision (coefficient of variation [CV%]) and percentage acceptable results...
July 19, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28729317/the-effects-of-physical-activity-interventions-on-glycated-haemoglobin-a1c-in-non-diabetic-populations-a-protocol-for-a-systematic-review-and-meta-analysis
#6
I Cavero-Redondo, B Peleteiro, C Álvarez-Bueno, M Garrido-Miguel, E G Artero, V Martinez-Vizcaino
INTRODUCTION: Epidemiological evidence suggests that physical activity has a positive effect on reducing glycated haemoglobin A1c (HbA1c) levels not only in diabetics, but also in healthy subjects. Moreover, a positive association of HbA1c levels with cardiovascular disease and mortality in non-diabetic populations has recently been reported. This is a protocol for a systematic review and meta-analysis aiming to estimate the effects of physical activity on glycaemic control measured by HbA1c levels in non-diabetic populations; and to determine which type of physical activity has a greater influence on glycaemic control...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28722290/development-of-a-cardiovascular-diseases-risk-prediction-model-and-tools-for-chinese-patients-with-type-2-diabetes-mellitus-a-population-based-retrospective-cohort-study
#7
Eric Yuk Fai Wan, Daniel Yee Tak Fong, Colman Siu Cheung Fung, Esther Yee Tak Yu, Weng Yee Chin, Anca Ka Chun Chan, Cindy Lo Kuen Lam
AIMS: Evidence-based cardiovascular diseases(CVD) risk prediction models and tools specific for Chinese patients with type 2 diabetes mellitus(T2DM) are currently unavailable. This study aimed to develop and validate a CVD risk prediction model for Chinese T2DM patients. MATERIALS AND METHODS: A retrospective cohort study was conducted on 137 935 Chinese patients aged 18-79 years with T2DM and without prior history of CVD, who had received public primary care services between 1 January 2010 and 31 December 2010...
July 19, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28710186/glycaemic-control-and-excess-risk-of-major-coronary-events-in-persons-with-type-1-diabetes
#8
Viktorija Matuleviciene-Anängen, Annika Rosengren, Ann-Marie Svensson, Aldina Pivodic, Soffia Gudbjörnsdottir, Hans Wedel, Mikhail Kosiborod, Börje Haraldsson, Marcus Lind
OBJECTIVE: The excess risk of major coronary events (acute myocardial infarction (AMI) or death from coronary heart disease (CHD)) in individuals with type 1 diabetes (T1D) in relation to glycaemic control and renal complications is not known. METHODS: Individuals with T1D in the Swedish National Diabetes Registry after 1 January 1998, without a previous MI (n=33 170) and 1 64 698 controls matched on age, sex and county were followed with respect to non-fatal AMI or death from CHD...
July 14, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28701152/performance-of-urinary-neutrophil-gelatinase-associated-lipocalin-clusterin-and-cystatin-c-in-predicting-diabetic-kidney-disease-and-diabetic-microalbuminuria-a-consecutive-cohort-study
#9
Xian-Fei Zeng, Dong-Xue Lu, Jun-Min Li, Yun Tan, Zhuo Li, Lei Zhou, Zeng-Qian Xi, Shu-Miao Zhang, Wei Duan
BACKGROUND: Tubular biomarkers have been regarded as emerging and promising markers for early diagnosis of diabetic kidney disease (DKD). The study was to determine the diagnostic capabilities of tubular biomarkers (urinary neutrophil gelatinase-associated lipocalin [NGAL], clusterin, and cystatin C) for DKD and diabetic microalbuminuria, and whether or not the tubular biomarkers appear earlier than microalbuminuria. METHODS: In this consecutive cohort study, 146 type 2 diabetes mellitus (T2DM) patients with a disease duration of ≥6 years were enrolled...
July 12, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28698534/the-effect-of-functional-insulin-therapy-on-glycaemic-parameters-in-children-with-diabetes-mellitus-type-1
#10
Diana Štimjanin-Koldžo, Salem Alajbegović, Ena Štimjanin, Jasmina Mehinagić
Aim The aim of the study is to evaluate the effect of a prospectively conducted interactive 5-day education programme based on Düsseldorf model on glycated haemoglobin (A1C), and total daily dose of insulin in type 1 diabetes patients. Methods A total of 67 type 1 diabetes patients was analysed; mean age of 11±0.68 years, 43 females and 24 males. The programme was led by a trained team of diabetes specialist doctors and nurses. All subjects and their parents completed a knowledge test about diabetes at beginning, and at the end of education, and after 12 months (30 questions)...
August 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/28694727/labile-glycated-haemoglobin-and-carbamylated-haemoglobin-are-still-critical-points-for-hba1c-measurement
#11
Aurore Desmons, Stéphane Jaisson, Nathalie Leroy, Philippe Gillery, Emmanuelle Guillard
INTRODUCTION: Haemoglobin A1c (HbA1c) is a key analyte for the monitoring of glycemic balance in diabetic patients and is used for diabetes diagnosis in many countries. The potential interference of carbamylated haemoglobin (cHb) and labile glycated haemoglobin (LA1c) on HbA1c assays must remain a matter of vigilance. Such a situation has occurred in our laboratory with a kit replacement on the Bio-Rad Variant™ II testing system, a cation-exchange high performance liquid chromatography (HPLC) system...
June 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28667223/lipid-lowering-drugs-and-risk-of-new-onset-diabetes-a-cohort-study-using-japanese-healthcare-data-linked-to-clinical-data-for-health-screening
#12
Nobuhiro Ooba, Soko Setoguchi, Tsugumichi Sato, Kiyoshi Kubota
OBJECTIVE: To investigate whether lipid-lowering drugs are associated with new-onset diabetes after adjusting for baseline clinical risk factors for diabetes. DESIGN: A retrospective cohort study. SETTING: Japanese employees of large corporations and their dependents using health insurance claims data linked to clinical and laboratory data for annual health screenings. PARTICIPANTS: All persons aged 20 to 74 years with dyslipidaemia between 1 January 2005 and 31 March 2011...
June 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28652217/tuberculosis-and-diabetes-in-nigerian-patients-with-and-without-hiv
#13
Lovett Lawson, Magdalena Muc, Olanrewaju Oladimeji, Chijioke Iweha, Blessing Opoola, Saddiq T Abdurhaman, John S Bimba, Luis E Cuevas
BACKGROUND: Type 2 diabetes mellitus (DM) and HIV increase the risk of tuberculosis (TB). The frequency of DM among patients with TB with and without HIV is poorly documented in many low- and middle-income countries. METHODS: This was a cross-sectional hospital-based study performed in Abuja, Nigeria. Adults with presumptive TB were screened consecutively. Sputum culture was used for TB screening and blood was used for HIV screening, as well as fasting plasma glucose (FPG) and glycated haemoglobin (HbA1c) assessment for the diagnosis of DM...
June 23, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28644050/hba1c-analysis-by-capillary-electrophoresis-comparison-with-chromatography-and-an-immunological-method
#14
Olav Klingenberg, Torill Furuset, Camilla R Hestbråten, Marit H Hallberg, Astrid Steiro, Iren R Orset, Jens P Berg
BACKGROUND: Haemoglobin A1c (HbA1c) has become an even more important analyte for clinical laboratories during recent years with the introduction of its diagnostic use for diabetes mellitus. Several different analytical principles can be used, each with their advantages and disadvantages. AIM: We wanted to compare Sebia Capillarys 2 Flex Piercing (Capillarys) with our routine HbA1c methods, which were an HPLC method (Tosoh G7) and an immunoassay (Tina-Quant on Roche Modular P) by analysing a large clinical material...
June 23, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28619952/cardiometabolic-correlates-of-sleep-disordered-breathing-in-andean-highlanders
#15
Luu V Pham, Catherine H Miele, Noah G Schwartz, Rafael S Arias, Adi Rattner, Robert H Gilman, J Jaime Miranda, Vsevolod Y Polotsky, William Checkley, Alan R Schwartz
Associations between sleep disordered breathing (SDB) and cardiometabolic outcomes have not been examined in highlanders.We performed nocturnal polygraphy in Peruvian highlanders (3825 m). Multivariable linear regression models examined associations between SDB metrics and haemoglobin, glucose tolerance (haemoglobin A1c (HbA1c)), fasting glucose, homeostatic model-based assessments of insulin resistance and β-cell function (HOMA-IR and HOMA-β, respectively), blood pressure, and lipids, while adjusting for age, sex, body mass index (BMI) and wake oxygenation...
June 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28611089/protocol-for-a-randomised-controlled-trial-evaluating-the-effects-of-providing-essential-medicines-at-no-charge-the-carefully-selected-and-easily-accessible-at-no-charge-medicines-clean-meds-trial
#16
Nav Persaud, Taehoon Lee, Haroon Ahmad, Winny Li, Michael Sergio Taglione, Yathavan Rajakulasingam, Norman Umali, Andrew Boozary, Richard H Glazier, Tara Gomes, Stephen W Hwang, Peter Jüni, Michael Law, Muhammad M Mamdani, Braden Manns, Danielle Martin, Steve Morgan, Paul Oh, Andrew David Pinto, Baiju R Shah, Frank M Sullivan, Kevin E Thorpe, Karen Tu, Andreas Laupacis
INTRODUCTION: Cost-related non-adherence to medicines is common in low-income, middle-income and high-income countries such as Canada. Medicine non-adherence is associated with poor health outcomes and increased mortality. This randomised trial will test the impact of a carefully selected list of essential medicines at no charge (compared with usual medicine access) in primary care patients reporting cost-related non-adherence. METHODS AND ANALYSIS: This is an open-label, parallel two-arm, superiority, individually randomised controlled trial conducted in three primary care sites (one urban, two rural) in Ontario, Canada, that was codesigned by a community guidance panel...
June 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28592573/protocol-for-a-randomised-controlled-trial-of-the-effect-of-dapagliflozin-metformin-and-exercise-on-glycaemic-variability-body-composition-and-cardiovascular-risk-in-prediabetes-the-pre-d-trial
#17
Kristine Færch, Hanan Amadid, Lea Bruhn Nielsen, Mathias Ried-Larsen, Kristian Karstoft, Frederik Persson, Marit Eika Jørgensen
INTRODUCTION: The primary aim of this study is to compare the efficacy of three short-term glucose-lowering interventions (exercise, metformin and dapagliflozin) on glycaemic variability in overweight or obese men and women with elevated diabetes risk (ie, prediabetes, defined as haemoglobin A1c (HbA1c)39-47 mmol/mol / 5.7%-6.4%). The secondary aims are to investigate the effects of the interventions on body composition and cardiometabolic risk factors. METHODS AND ANALYSIS: The Pre-D Trial is an investigator-initiated, randomised, controlled, parallel, open-label, superiority trial...
June 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28588112/the-hoorn-diabetes-care-system-dcs-cohort-a-prospective-cohort-of-persons-with-type-2-diabetes-treated-in-primary-care-in-the-netherlands
#18
Amber Awa van der Heijden, Simone P Rauh, Jacqueline M Dekker, Joline W Beulens, Petra Elders, Leen M 't Hart, Femke Rutters, Nienke van Leeuwen, Giel Nijpels
PURPOSE: People with type 2 diabetes (T2D) have a doubled morbidity and mortality risk compared with persons with normal glucose tolerance. Despite treatment, clinical targets for cardiovascular risk factors are not achieved. The Hoorn Diabetes Care System cohort (DCS) is a prospective cohort representing a comprehensive dataset on the natural course of T2D, with repeated clinical measures and outcomes. In this paper, we describe the design of the DCS cohort. PARTICIPANTS: The DCS consists of persons with T2D in primary care from the West-Friesland region of the Netherlands...
June 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28585725/laboratory-parameter-based-machine-learning-model-for-excluding-non-alcoholic-fatty-liver-disease-nafld-in-the-general-population
#19
T C-F Yip, A J Ma, V W-S Wong, Y-K Tse, H L-Y Chan, P-C Yuen, G L-H Wong
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) affects 20%-40% of the general population in developed countries and is an increasingly important cause of hepatocellular carcinoma. Electronic medical records facilitate large-scale epidemiological studies, existing NAFLD scores often require clinical and anthropometric parameters that may not be captured in those databases. AIM: To develop and validate a laboratory parameter-based machine learning model to detect NAFLD for the general population...
August 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28584189/the-efficacy-of-motivational-counselling-and-sms-reminders-on-daily-sitting-time-in-patients-with-rheumatoid-arthritis-a-randomised-controlled-trial
#20
Tanja Thomsen, Mette Aadahl, Nina Beyer, Merete Lund Hetland, Katrine Løppenthin, Julie Midtgaard, Robin Christensen, Mikkel Østergaard, Poul Jørgen Jennum, Bente Appel Esbensen
OBJECTIVES: The aim of this report is to investigate the efficacy of an individually tailored, theory-based behavioural intervention for reducing daily sitting time, pain and fatigue, as well as improving health-related quality of life, general self-efficacy, physical function and cardiometabolic biomarkers in patients with rheumatoid arthritis (RA). METHODS: In this randomised controlled trial 150 patients with RA were randomised to an intervention or a no-intervention control group...
September 2017: Annals of the Rheumatic Diseases
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