keyword
MENU ▼
Read by QxMD icon Read
search

Udenafil

keyword
https://www.readbyqxmd.com/read/27319276/a-phase-3-study-to-evaluate-the-1-year-efficacy-and-safety-of-udenafil-75-mg-once-daily-in-patients-with-erectile-dysfunction
#1
Ki Hak Moon, Sae Woong Kim, Du Geon Moon, Je Jong Kim, Nam Cheol Park, Sung Won Lee, Jae-Seung Paick, Tai Young Ahn, Woo Sik Chung, Kwon Sik Min, Jong Kwan Park, Dae Yul Yang, Hong Seok Shin, Kwangsung Park
INTRODUCTION: Once-daily administration of phosphodiesterase type 5 inhibitors has been shown to correct erectile dysfunction (ED). AIM: To evaluate the long-term efficacy and safety after once-daily oral administration of udenafil 75 mg in men with ED. METHODS: This clinical trial was an open-label, fixed-dose, 24-week extension study (DA8159_EDDL_III) of a 24-week double-blinded efficacy and safety study of once-daily udenafil (parent study: DA8159_EDD_III)...
August 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27084997/population-pharmacokinetic-analysis-to-recommend-the-optimal-dose-of-udenafil-in-patients-with-mild-and-moderate-hepatic-impairment
#2
Anhye Kim, Jongtae Lee, Donghoon Shin, Yong Jin Jung, Mi Young Bahng, Joo-Youn Cho, In-Jin Jang
AIMS: The aim of this study was to develop a population pharmacokinetic (PK) model of udenafil and its active metabolite, DA-8164, in healthy subjects and patients with hepatic impairment (HI) and to estimate the optimal dosing recommendations for patients with HI. METHODS: An open label, three parallel group, age and weight matched control study was conducted in 18 volunteers, six healthy subjects (n = 6) and patients with mild (Child-Pugh class A, n = 6) and moderate HI (Child-Pugh class B, n = 6)...
August 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27006150/the-effect-of-age-on-the-pharmacokinetics-of-udenafil-in-healthy-subjects
#3
Hyang-Ki Choi, Jin Ah Jung, Mi Young Bahng, Doo-Yeon Cho, Chang Woo Yeo, Eun-Young Kim, Jae-Gook Shin
Udenafil, a cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) inhibitor, has been developed to treat erectile dysfunction. We evaluated the effect of age on the pharmacokinetics and tolerability of udenafil. A single-center, open-label, parallel-group phase 1 study was conducted in healthy adult subjects who took a single oral dose of udenafil (100 mg). The pharmacokinetics and tolerability of udenafil were compared between 12 healthy young males (21-27 years) and 12 healthy elderly males (65-78 years)...
March 23, 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/26965160/factors-predicting-outcomes-of-penile-rehabilitation-with-udenafil-50-mg-following-radical-prostatectomy
#4
T H Kim, Y-S Ha, S H Choi, E S Yoo, B W Kim, S-J Yun, W-J Kim, Y S Kwon, T G Kwon
No abstract text is available yet for this article.
March 2016: International Journal of Impotence Research
https://www.readbyqxmd.com/read/26727286/the-efficacy-of-udenafil-in-end-stage-renal-disease-patients-undergoing-hemodialysis
#5
Lokman Irkilata, Hasan Riza Aydin, Ismail Ozer, Mustafa Aydin, Hüseyin Cihan Demirel, Caner Moral, Mustafa Kemal Atilla
INTRODUCTION: Erectile dysfunction (ED) is frequently observed in end-stage renal disease (ESRD) patients on hemodialysis (HD) compared to non-uremic patients. This situation causes severe psychogenic problems in patients and disrupts the quality of life. Different phosphodiesterase type 5 (PDE-5) inhibitors have been used, and efficacies revealed, for the treatment of ED in HD patients; however, there are no studies related to udenafil use or results for HD patients. This study retrospectively evaluated the efficacy and reliability of udenafil for HD patients...
2016: Renal Failure
https://www.readbyqxmd.com/read/26510966/factors-predicting-outcomes-of-penile-rehabilitation-with-udenafil-50%C3%A2-mg-following-radical-prostatectomy
#6
T-H Kim, Y-S Ha, S H Choi, E S Yoo, B W Kim, S-J Yun, W-J Kim, Y S Kwon, T G Kwon
Udenafil is a selective phosphodiesterase type 5 inhibitor made available in recent years for the treatment of erectile dysfunction. Herein, we evaluated independent predictors of potency recovery in radical prostatectomy (RP) patients who underwent penile rehabilitation with udenafil 50 mg. One hundred and forty-three men who underwent RP were enrolled in a penile rehabilitation program using udenafil 50 mg every other day. The rate of regained potency in the study group was significantly higher compared with the recovery rate seen in patients who were not part of the penile rehabilitation program (41...
January 2016: International Journal of Impotence Research
https://www.readbyqxmd.com/read/26447600/additive-effects-of-artemisia-capillaris-extract-and-scopoletin-on-the-relaxation-of-penile-corpus-cavernosum-smooth-muscle
#7
B R Choi, S K Kumar, C Zhao, L T Zhang, C Y Kim, S W Lee, J-H Jeon, K K Soní, I So, S H Kim, N C Park, H K Kim, J K Park
The objective was to investigate the cellular effect and action mechanism of Artemisia capillaris extract (ACE) and its component, scopoletin, on penile corpus cavernosum smooth muscle (PCCSM). In vitro study with PCCSM, the precontracted PCCSM with phenylephrine was treated with ACE or scopoletin. Cyclic nucleotides in the perfusate were measured by radioimmunoassay and expression of protein and mRNA of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase in the perfused PCCSM were measured by western blot and real-time PCR, respectively...
November 2015: International Journal of Impotence Research
https://www.readbyqxmd.com/read/26393163/an-observational-study-to-evaluate-the-prevalence-of-erectile-dysfunction-ed-and-prescribing-pattern-of-drugs-in-patients-with-ed-visiting-an-andrology-specialty-clinic-mumbai-2012-14
#8
Amit S Mutha, Vijay R Kulkarni, Sagar B Bhagat, Amit S Beldar, Sadiq B Patel
INTRODUCTION: Erectile dysfunction (ED) is a common occurrence and its incidence is expected to increase significantly along with the increase in various lifestyle diseases. The drug utilization for ED is very low. Also, studies describing the prescription pattern in ED are lacking. MATERIALS AND METHODS: We conducted a retrospective cross-sectional observational study, including a drug utilization analysis, of 606 prescriptions as per the standard guidelines (WHO and STROBE)...
July 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26354054/oral-udenafil-and-aceclofenac-for-the-prevention-of-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-in-high-risk-patients-a-randomized-multicenter-study
#9
RANDOMIZED CONTROLLED TRIAL
Tae Yoon Lee, Jung Sik Choi, Hyoung-Chul Oh, Tae Jun Song, Jae Hyuk Do, Young Koog Cheon
BACKGROUND/AIMS: Acute pancreatitis is a common complication of endoscopic retrograde cholangiopancreatography (ERCP). Combination therapy w ith ora l udenafil and aceclofenac may reduce the occurrence of post-ERCP pancreatitis by targeting different pathophysiological mechanisms. We investigated whether combining udenafil and aceclofenac reduced the rates of post-ERCP pancreatitis. METHODS: A prospective, randomized, double-blind, placebo-controlled, multicenter study was conducted in four academic medical centers...
September 2015: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/26195408/re-efficacy-of-once-daily-administration-of-udenafil-for-24-weeks-on-erectile-dysfunction-results-from-a-randomized-multicenter-placebo-controlled-clinical-trial
#10
COMMENT
https://www.readbyqxmd.com/read/26027619/pde-5-inhibition-with-udenafil-improves-left-ventricular-systolic-diastolic-functions-and-exercise-capacity-in-patients-with-chronic-heart-failure-with-reduced-ejection-fraction-a-12-week-randomized-double-blind-placebo-controlled-trial
#11
RANDOMIZED CONTROLLED TRIAL
Kyung-Hee Kim, Hyung-Kwan Kim, In-Chang Hwang, Hyun-Jai Cho, Nari Je, Oh-Min Kwon, Su-Jeong Choi, Seung-Pyo Lee, Yong-Jin Kim, Dae-Won Sohn
BACKGROUND: Impaired nitric oxide-mediated pulmonary vascular tone is commonly found in heart failure with reduced ejection fraction (HFrEF), and is associated with derangement of left ventricular (LV) hemodynamics and decreased exercise capacity, which may be reversed by PDE5 inhibitor. This study investigated the effects of a new, long-acting PDE5 inhibitor on LV hemodynamics and exercise capacity in HFrEF. METHODS: Patients with chronic HFrEF on optimal medical therapy for >30 days before enrollment were randomly assigned to placebo or udenafil at a dose of 50mg 2x/day for the first 4 weeks followed by 100mg 2x/day for the next 8 weeks...
June 2015: American Heart Journal
https://www.readbyqxmd.com/read/25890547/re-comparison-of-the-efficacy-and-safety-of-once-daily-dosing-and-on-demand-use-of-udenafil-for-type-2-diabetic-patients-with-erectile-dysfunction
#12
EDITORIAL
https://www.readbyqxmd.com/read/25860455/stem-cell-therapy-for-erectile-dysfunction-of-cavernous-nerve-injury-rats-a-systematic-review-and-meta-analysis
#13
REVIEW
Haitao Shan, Fengzhi Chen, Tao Zhang, Shuhua He, Le Xu, Anyang Wei
INTRODUCTION: Stem cell treatment is a novel therapeutic strategy for erectile dysfunction (ED) patients with bilateral cavernous nerve injury (CNI). The relative animal studies provide important clues to design pre-clinical studies and clinical studies further in the future. PURPOSE: This study aims to evaluate the effects and influential factors of stem cell transplantation on ED rats with CNI. MATERIALS AND METHODS: We searched PubMed and EBSCO databases published before April 30, 2014 for pre-clinical studies to evaluate the efficacy of stem cell transplantation in the treatment of ED rats with CNI...
2015: PloS One
https://www.readbyqxmd.com/read/25832922/therapeutic-effects-of-udenafil-on-pressure-overload-cardiac-hypertrophy
#14
Hack-Lyoung Kim, Yong-Jin Kim, Kyung-Hee Kim, Seung-Pyo Lee, Hyung-Kwan Kim, Dae-Won Sohn, Byung-Hee Oh, Young-Bae Park
This study was performed to determine whether the newly developed phosphodiesterase type 5 (PDE5) inhibitor udenafil had beneficial effects on pressure-overload cardiac hypertrophy. Pressure overload cardiac hypertrophy was created by using suprarenal aortic constriction (SAC) in male Sprague-Dawley rats. Rats were divided into three groups: sham (n=19), SAC (n=18) and SAC+udenafil (n=14) groups. Three-week periods of SAC provoked significant left ventricular (LV) hypertrophy. Udenafil was administered (20 mg kg(-1) PO, daily) between the 3rd and 20th weeks after SAC in the SAC+udenafil group...
September 2015: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/25817916/phosphodiesterase-5-inhibitors-for-the-treatment-of-erectile-dysfunction-a-trade-off-network-meta-analysis
#15
REVIEW
Liang Chen, Sergej E L Staubli, Marc P Schneider, Alfons G Kessels, Sandra Ivic, Lucas M Bachmann, Thomas M Kessler
CONTEXT: Erectile dysfunction (ED) is a major health care problem worldwide and phosphodiesterase 5 inhibitors (PDE5Is) are the pharmacological treatment of choice. However, the optimal PDE5I for ED treatment is not known. OBJECTIVE: To investigate trade-offs between efficacy and adverse events for various PDE5Is in treating ED. EVIDENCE ACQUISITION: A review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement...
October 2015: European Urology
https://www.readbyqxmd.com/read/25800396/erectile-dysfunction-once-daily-udenafil-improves-erectile-function
#16
(no author information available yet)
No abstract text is available yet for this article.
May 2015: Nature Reviews. Urology
https://www.readbyqxmd.com/read/25759565/pharmacokinetic-interaction-between-udenafil-and-dapoxetine-a-randomized-open-labeled-crossover-study-in-healthy-male-volunteers
#17
RANDOMIZED CONTROLLED TRIAL
Yo Han Kim, Hee Youn Choi, Shi Hyang Lee, Hae Sun Jeon, Hyeong-Seok Lim, Mi Young Bahng, Kyun-Seop Bae
BACKGROUND: "Udenafil" is a phosphodiesterase-5 inhibitor indicated for erectile dysfunction. "Dapoxetine" is a serotonin transport inhibitor indicated for premature ejaculation. The aim of the study reported here was to investigate the pharmacokinetic drug interaction between udenafil and dapoxetine in healthy male subjects. METHODS: An open-label, three-treatment, six-sequence, three-period crossover study was performed in healthy male subjects. In varying sequences, each subjects received single oral doses of udenafil 200 mg, dapoxetine 60 mg, and both treatments...
2015: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/25531864/an-lc-ms-ms-method-for-the-determination-of-five-erectile-dysfunction-drugs-and-their-selected-metabolites-in-hair
#18
Sooyeun Lee, Boyeon Choi, Jihyun Kim, Sanghwan In, Seungkyung Baeck, Seung Min Oh, Kyu Hyuck Chung
The abuse of sildenafil and its analogous, accelerated by their inappropriate or illegal distribution, is a serious social issue globally. However, no studies have been conducted to monitor these drugs simultaneously in hair, which can provide valuable information on chronic drug use. In the present study, an LC-MS/MS method was developed for the simultaneous determination in hair of five erectile dysfunction drugs having a high risk for abuse (mirodenafil, sildenafil, tadalafil, udenafil and vardenafil) and their selected metabolites (SK3541, desmethylsildenafil, DA8164 and desethylvardenafil)...
January 26, 2015: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/25483910/the-phosphodiesterase-5-inhibitor-udenafil-lowers-portal-pressure-in-compensated-preascitic-liver-cirrhosis-a-dose-finding-phase-ii-study
#19
MULTICENTER STUDY
Wolfgang Kreisel, Peter Deibert, Limas Kupcinskas, Jolanta Sumskiene, Beate Appenrodt, Susanne Roth, Michaela Neagu, Martin Rössle, Alexander Zipprich, Karel Caca, Arnulf Ferlitsch, Karin Dilger, Ralf Mohrbacher, Roland Greinwald, Tilman Sauerbruch
BACKGROUND: Phosphodiesterase-5-inhibitors may lower portal pressure. AIMS: To investigate the effect of the phosphodiesterase-5-inhibitor udenafil on hepatic and systemic haemodynamics in liver cirrhosis. METHODS: In an open-label phase-II-study, patients with liver cirrhosis Child A/B and hepatic venous pressure-gradient ≥ 12 mmHg received 12.5mg/day, 25mg/day, 50mg/day, 75 mg/day (n = 5, each), or 100mg/day (n = 10) udenafil p.o. for one week...
February 2015: Digestive and Liver Disease
https://www.readbyqxmd.com/read/25482466/efficacy-and-safety-of-udenafil-for-the-treatment-of-erectile-dysfunction-after-total-mesorectal-excision-of-rectal-cancer-a-randomized-double-blind-placebo-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
Soo Yeun Park, Gyu-Seog Choi, Jun Seok Park, Hye Jin Kim, Ju-A Park, Jong Ik Choi
BACKGROUND: Nerve-preserving surgery has been provided for patients with rectal cancer; however, sexual dysfunction remains a common complication of rectal cancer surgery. This study explored the efficacy of udenafil to treat erectile dysfunction in male patients who underwent total mesorectal excision (TME) for rectal cancer. METHODS: We conducted a randomized, double-blind, placebo-controlled clinical trial involving 80 male patients who had decreased International Index of Erectile Function-5 (IIEF-5) scores after TME for rectal cancer...
January 2015: Surgery
keyword
keyword
53006
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"