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https://www.readbyqxmd.com/read/27658991/-efficacy-and-tolerance-of-pde-5%C3%A2-in-the-treatment-of-erectile-dysfunction-in-schizophrenic-patients-a-literature-review
#1
L Bacconi, F Gressier
INTRODUCTION: Sexual dysfunction is an important public health problem in men and is associated with reduced quality of life. It is more common in patients with schizophrenia. It is well-established that antipsychotic drugs cause sexual dysfunction with consequences on the quality of life of patients, adherence to treatment, and public health costs. Phosphodiesterase type 5 inhibitors (PDE5 inhibitors) are indicated for the management of erectile dysfunction. However, there is little information on such treatment in schizophrenic patients...
September 19, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27062069/psychotherapy-and-phosphodiesterase-5-inhibitor-in-early-rehabilitation-after-radical-prostatectomy-a-prospective-randomised-controlled-trial
#2
A M E P Naccarato, L O Reis, U Ferreira, F Denardi
The aim of this study was to evaluate the impact of group psychotherapy and the use of a phosphodiesterase-5 inhibitor (PDE-5i) in the early rehabilitation stage of patients with prostate cancer undergoing radical prostatectomy (RP). Fifty-six patients undergoing RP for prostate cancer were randomised into four groups, and 53 completed the protocol: Group 1 - control (n = 11), Group 2 - group psychotherapy (n = 16), Group 3 - lodenafil 80 mg/one tablet per week (n = 12) and Group 4 - group psychotherapy + lodenafil 80 mg/one tablet per week (n = 14)...
April 6, 2016: Andrologia
https://www.readbyqxmd.com/read/25210965/lodenafil-treatment-in-the-monocrotaline-model-of-pulmonary-hypertension-in-rats
#3
Igor Bastos Polonio, Milena Marques Pagliareli Acencio, Rogério Pazetti, Francine Maria de Almeida, Bárbara Soares da Silva, Karina Aparecida Bonifácio Pereira, Rogério Souza
We assessed the effects of lodenafil on hemodynamics and inflammation in the rat model of monocrotaline-induced pulmonary hypertension (PH). Thirty male Sprague-Dawley rats were randomly divided into three groups: control; monocrotaline (experimental model); and lodenafil (experimental model followed by lodenafil treatment, p.o., 5 mg/kg daily for 28 days) Mean pulmonary artery pressure (mPAP) was obtained by right heart catheterization. We investigated right ventricular hypertrophy (RVH) and IL-1 levels in lung fragments...
July 2014: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/25068906/decision-tree-analyses-of-key-patient-characteristics-in-middle-eastern-north-african-and-latin-american-men-treated-with-long-acting-and-short-acting-pde5-inhibitors-for-erectile-dysfunction
#4
Eusebio Rubio-Aurioles, Amr El-Meliegy, Samer Abdulwahed, Carsten Henneges, Sebastian Sorsaburu, Sirel Gurbuz
BACKGROUND: Phosphodiesterase type 5 (PDE5) inhibitors have discontinuation rates as high as 60% in men with erectile dysfunction. Treatment satisfaction has been significantly associated with treatment continuation. Understanding key characteristics in terms of treatment preference, relationship, and lifestyle issues could provide direction on how to improve compliance with PDE5 inhibitor treatment globally. OBJECTIVE: The objective was to identify subgroups of interest in the pooled database of two observational studies conducted in Latin America (LA) and Middle East/North Africa (MENA) exploring patient characteristics and prescription of either a long- or short-acting PDE5 inhibitor at baseline...
February 2015: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/25010306/pde5-inhibitor-treatment-persistence-and-adherence-in-brazilian-men-post-hoc-analyses-from-a-6-month-prospective-observational-study
#5
Carlos Cairoli, Luis Antonio Reyes, Carsten Henneges, Sebastian Sorsaburu
PURPOSE: Characterize persistence and adherence to phosphodiesterase type - 5 inhibitor (PDE5I) on-demand therapy over 6 months among Brazilian men in an observational, non-interventional study of Latin American men naïve to PDE5Is with erectile dysfunction (ED). MATERIALS AND METHODS: Men were prescribed PDE5Is per routine clinical practice. Persistence was defined as using ≥ 1 dose during the previous 4 - weeks, and adherence as following dosing instructions for the most recent dose, assessed using the Persistence and Adherence Questionnaire...
May 2014: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/23656343/phosphodiesterase-inhibitors-in-clinical-urology
#6
REVIEW
Stefan Ückert, Markus A Kuczyk, Matthias Oelke
To date, benign diseases of the male and female lower urinary and genital tract, such as erectile dysfunction, bladder overactivity, lower urinary tract symptomatology secondary to benign prostatic hyperplasia and symptoms of female sexual dysfunction (including arousal and orgasmic disorders), can be therapeutically approached by influencing the function of the smooth musculature of the respective tissues. The use of isoenzyme-selective phosphodiesterase (PDE) inhibitors is considered a great opportunity to treat various diseases of the human urogenital tract...
May 2013: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/23614829/development-and-validation-of-a-dissolution-test-for-lodenafil-carbonate-based-on-in-vivo-data
#7
Cristiane Franco Codevilla, Tamara dos Santos Castilhos, Carolina Araújo Cirne, Pedro Eduardo Froehlich, Ana Maria Bergold
INTRODUCTION: Lodenafil carbonate is a phosphodiesterase type 5 inhibitor used for the treatment of erectile dysfunction. Currently, there is no dissolution test reported for lodenafil carbonate and this drug is not listed in any pharmacopoeia. OBJECTIVE: The present study focused on the development and validation of a dissolution test for lodenafil carbonate tablets, using a simulated absorption profile based on in vivo data. METHODS: The appropriate conditions were determined after testing sink conditions...
April 2014: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/23540375/a-6-month-prospective-observational-study-of-pde5-inhibitor-treatment-persistence-and-adherence-in-latin-american-men-with-erectile-dysfunction
#8
Eusebio Rubio-Aurioles, Luis Antonio Reyes, Leonardo Borregales, Carlos Cairoli, Sebastian Sorsaburu
Abstract Objectives: To assess persistence/adherence rates of phosphodiesterase type-5 inhibitor (PDE5I) on-demand dosing in Latin American men with erectile dysfunction (ED), and explore patient characteristics and treatment factors that may be predictive for PDE5I persistence and adherence. Methods: Men from Brazil, Mexico, and Venezuela with ED who were naïve to PDE5Is were prescribed sildenafil, tadalafil, vardenafil, or lodenafil on-demand dosing and asked to provide information about PDE5I use at baseline and at 1, 3, and 6 months...
June 2013: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/23372609/avanafil-for-the-treatment-of-erectile-dysfunction-initial-data-and-clinical-key-properties
#9
George T Kedia, Stefan Uckert, Farhang Assadi-Pour, Markus A Kuczyk, Knut Albrecht
Orally active, selective inhibitors of phosphodiesterase type 5 (PDE 5, cyclic GMP PDE), such as sildenafil, tadalafil and vardenafil, are currently the first-choice treatment options for the clinical management of erectile dysfunction (ED) of various etiologies and severities. However, a significant number of patients remain dissatisfied with the available therapies due a lack of efficacy or discomfort arising from adverse events. Several new PDE5 inhibitors, among which are avanafil (TA-1790), lodenafil, mirodenafil, udenafil, SLX-2101, JNJ-10280205 and JNJ-10287069, have recently been approved and introduced into the market or are in the final stages of their clinical development...
February 2013: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/23350632/adjunctive-treatment-with-lodenafil-carbonate-for-erectile-dysfunction-in-outpatients-with-schizophrenia-and-spectrum-a-randomized-double-blind-crossover-placebo-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Luciana Vargas Alves Nunes, Fernando Sargo Lacaz, Rodrigo Affonseca Bressan, Sandra Odebrecht Vargas Alves Nunes, Jair de Jesus Mari
INTRODUCTION.: Evidence is accumulating to support the presence of erectile dysfunction in patients with schizophrenia. This dysregulation may be amenable to therapeutic intervention to improve adherence and quality of life of patients who suffer from schizophrenia and schizoaffective disorders. AIM.: We aimed to evaluate the use of adjunctive medication lodenafil for the treatment of erectile dysfunction in outpatients with schizophrenia and spectrum. METHODS.: The design was a randomized, double-blind, crossover, placebo-controlled trial with lodenafil and it was carried at the Schizophrenia Outpatients Program...
April 2013: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/23073140/a-phase-i-clinical-trial-of-lodenafil-carbonate-a-new-phosphodiesterase-type-5-pde5-inhibitor-in-healthy-male-volunteers
#11
Gustavo D Mendes, Hilton Oliveira dos Santos Filho, Alberto dos Santos Pereira, Fabiana D Mendes, Jaime O Ilha, Khalid M Alkharfy, Gilberto De Nucci
UNLABELLED: Lodenafil carbonate is a new phosphodiesterase Type 5 (PDE5) inhibitor used in treatment of erectile dysfunction. OBJECTIVE: The present study was conducted to evaluate the safety, tolerability, and pharmacokinetics of lodenafil carbonate after administering ascending (1 - 100 mg) single oral doses to healthy male volunteers (n = 33). METHODS: The study was an open label, dose-escalation, Phase I clinical trial involving the administration of single oral doses of lodenafil carbonate...
December 2012: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/21801480/development-and-validation-of-a-stability-indicating-lc-method-for-the-assay-of-lodenafil-carbonate-in-tablets
#12
Cristiane Franco Codevilla, Alice Machado Lemos, Leila Schreiner Delgado, Clarice Madalena Bueno Rolim, Andréa Inês Horn Adams, Ana Maria Bergold
A stability-indicating liquid chromatographic method has been developed for the quantitative determination of lodenafil carbonate in tablets. The method employs a Synergi Fusion C18 column (250 × 4.6 mm, i.d., 4 μm particle size), with mobile phase consisting of a mixture of methanol-acetic acid 0.1% pH 4.0 (65:35, v/v) and UV detection at 290 nm, using a photodiode array detector. A linear response (r = 0.9999) was observed in the range of 10-80 μg/mL. The method showed good recoveries (average 100.3%) and also intra and inter-day precision (RSD < 2...
August 2011: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/21585174/the-management-of-erectile-dysfunction-innovations-and-future-perspectives
#13
Rosario Leonardi, Matteo Alemanni
Phosphodiesterase 5 (PDE5) inhibitors are recommended as first line therapy for the treatment of erectile dysfunction (ED). To date, three PDE5 inhibitors are on the market: sildenafil, vardenafil and tadalafil. These compounds are available as oral tablets; they are rapidly absorbed in the gastrointestinal tract and are excreted mainly in the fces and to a lexer extent in the urine. Recently, an orodisnersible formulation of feces and, to a lesser extent, in the urine. Recently, an orodispersible formulation of vardenafil (vardenafil ODT) has been developed, which is able to dissolve in the mouth within seconds, releasing a minty flavor, without the need of being swallowed with water...
March 2011: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/20428608/-cardiovascular-repercussion-of-lodenafil-carbonate-a-new-pde5-inhibitor-with-and-without-alcohol-consumption
#14
Adauto Carvalho Silva, Odaly Toffoletto, Luiz Antonio Galvão Lucio, Paula Ferreira Dos Santos, Jorge Barros Afiune, João Massud Filho, Sergio Tufik
BACKGROUND: Millions of men around the world suffer from erectile dysfunction, for which phosphodiesterase 5 inhibitors (PDE-5 inhibitors) are currently the first treatment option. Sexual activity and alcohol consumption are closely related, and the simultaneous use of alcohol and PDE-5 inhibitors can happen. Lodenafil carbonate is a new PDE-5 inhibitor, developed by a Brazilian pharmaceutical company. OBJECTIVE: This work aimed at evaluating the cardiovascular safety of lodenafil carbonate, with and without simultaneous alcohol consumption...
February 2010: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/20214718/efficacy-and-tolerability-of-lodenafil-carbonate-for-oral-therapy-of-erectile-dysfunction-a-phase-iii-clinical-trial
#15
RANDOMIZED CONTROLLED TRIAL
Sidney Glina, Gilvan N Fonseca, Eduardo B Bertero, Ronaldo Damião, Luíz C A Rocha, Carlos R F Jardim, Carlos E Cairoli, Cláudio Teloken, Luiz O Torres, Geraldo E Faria, Marcelo B da Silva, Eduardo Pagani
INTRODUCTION: This is a phase III, prospective, randomized, double-blind, placebo-controlled clinical trial on lodenafil carbonate (LC), a novel phosphodiesterase 5 inhibitor developed in Brazil. AIM: Expanding information on LC efficacy and safety. MAIN OUTCOME MEASURES: International Index of Erectile Function (IIEF) erectile domain, positive answers to the sexual encounter profile (SEP)-2 and SEP-3 questions and incidence of adverse events (AEs)...
May 2010: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/19040623/efficacy-and-tolerability-of-lodenafil-carbonate-for-oral-therapy-in-erectile-dysfunction-a-phase-ii-clinical-trial
#16
RANDOMIZED CONTROLLED TRIAL
Sidney Glina, Iderpol Toscano, Celso Gomatzky, Plínio Moreira de Góes, Archimedes Nardozza Júnior, Joaquim Francisco de Almeida Claro, Eduardo Pagani
INTRODUCTION: Oral treatment with phosphodiesterase type 5 inhibitor (PDE5) is considered the first-line treatment for patients with erectile dysfunction (ED). Lodenafil carbonate (LC) is a novel PDE5. AIM: This is a phase II, prospective, randomized, double-blind, and placebo controlled clinical trial of LC. MAIN OUTCOME MEASURES: Efficacy end points were International Index of Sexual Function (IIEF) erectile domain, IIEF questions 3 and 4, and Sexual Encounter Profile (SEP) questions 2 and 3, before and after the use of LC or placebo...
February 2009: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/18593576/pharmacological-characterization-of-a-novel-phosphodiesterase-type-5-pde5-inhibitor-lodenafil-carbonate-on-human-and-rabbit-corpus-cavernosum
#17
COMPARATIVE STUDY
Haroldo A Toque, Cleber E Teixeira, Raquel Lorenzetti, Cristina E Okuyama, Edson Antunes, Gilberto De Nucci
Nitrergic nerves and endothelial cells release nitric oxide (NO) in the corpus cavernosum, a key mediator that stimulates soluble guanylyl cyclase to increase cGMP levels causing penile erection. Phosphodiesterase 5 (PDE5) inhibitors, such as sildenafil, prolong the NO effects by inhibiting cGMP breakdown. Here, we report a novel PDE5 inhibitor, lodenafil carbonate, (Bis-(2-{4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-benzenesulfonyl]piperazin-1-yl}-ethyl)carbonate) that is a dimer of lodenafil...
September 4, 2008: European Journal of Pharmacology
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