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Immunogenetics

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https://www.readbyqxmd.com/read/28768193/immunogenetic-profiling-for-gastric-cancers-identifies-sulfated-glycosaminoglycans-as-major-and-functional-b-cell-antigens-in-human-malignancies
#1
Hiroto Katoh, Daisuke Komura, Hiroki Konishi, Ryohei Suzuki, Asami Yamamoto, Miwako Kakiuchi, Reiko Sato, Tetsuo Ushiku, Shogo Yamamoto, Kenji Tatsuno, Takashi Oshima, Sachiyo Nomura, Yasuyuki Seto, Masashi Fukayama, Hiroyuki Aburatani, Shumpei Ishikawa
Recent successes in tumor immunotherapies have highlighted the importance of tumor immunity. However, most of the work conducted to date has been on T cell immunity, while the role of B cell immunity in cancer remains more elusive. In this study, immunogenetic repertoire profiling for tumor-infiltrating B and T cells in gastric cancers was carried out to help reveal the architecture of B cell immunity in cancer. Humoral immunity in cancer was shown to involve oligoclonal expansions of tumor-specific and private B cell repertoires...
August 1, 2017: Cell Reports
https://www.readbyqxmd.com/read/28765516/next-generation-sequencing-in-chronic-lymphocytic-leukemia-recent-findings-and-new-horizons
#2
REVIEW
Ana E Rodríguez-Vicente, Vasilis Bikos, María Hernández-Sánchez, Jitka Malcikova, Jesús-María Hernández-Rivas, Sarka Pospisilova
The rapid progress in next-generation sequencing technologies has significantly contributed to our knowledge of the genetic events associated with the development, progression and treatment resistance of chronic lymphocytic leukemia patients. Together with the discovery of new driver mutations, next-generation sequencing has revealed an immense degree of both intra- and inter-tumor heterogeneity and enabled us to describe marked clonal evolution. Advances in immunogenetics may be implemented to detect minimal residual disease more sensitively and to track clonal B cell populations, their dynamics and molecular characteristics...
July 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28755388/kir-on-the-cusp%C3%A2-of%C3%A2-modern-immunogenetics
#3
REVIEW
Francesco Colucci, James Traherne
Killer Immunoglobulin-like Receptors (KIR) and their Human Leukocyte Antigen (HLA) ligands play a central role in immunity and human health. These molecules are encoded by gene families with copy number variation, extreme levels of sequence diversity and complex expression patterns. The rapid evolution of KIR and HLA genes and their associations with infectious diseases, pregnancy disorders, immunopathologies and outcome of cell transplantation has generated considerable interest from immunologists, geneticists and clinicians...
July 29, 2017: Immunology
https://www.readbyqxmd.com/read/28743384/publication-ethos-in-the-immunogenetics-community
#4
EDITORIAL
Amy B Hahn, Steven G E Marsh, Derek Middleton
No abstract text is available yet for this article.
July 2017: Human Immunology
https://www.readbyqxmd.com/read/28695290/major-histocompatibility-complex-variation-and-the-evolution-of-resistance-to-amphibian-chytridiomycosis
#5
REVIEW
Minjie Fu, Bruce Waldman
Chytridiomycosis, caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), has been implicated in population declines and species extinctions of amphibians around the world. Susceptibility to the disease varies both within and among species, most likely attributable to heritable immunogenetic variation. Analyses of transcriptional expression in hosts following their infection by Bd reveal complex responses. Species resistant to Bd generally show evidence of stronger innate and adaptive immune system responses...
July 10, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28695288/introduction-mhc-kir-and-governance-of-specificity
#6
REVIEW
Adrian Kelly, John Trowsdale
The MHC controls specificity, to ensure that appropriate immune responses are mounted to invading pathogens whilst maintaining tolerance to the host. It encodes molecules that act as sentinels, providing a snapshot of the health of the interior and exterior of the cell for immune surveillance. To maintain the ability to respond appropriately to any disease requires a delicate balance of expression and function, and many subtleties of the system have been described at the gene, individual and population level...
August 2017: Immunogenetics
https://www.readbyqxmd.com/read/28695282/host-genetic-variation-and-hiv-disease-from-mapping-to-mechanism
#7
REVIEW
Vivek Naranbhai, Mary Carrington
This review aims to provide a summary of current knowledge of host genetic effects on human immunodeficiency virus (HIV) disease. Mapping of simple single nucleotide polymorphisms (SNP) has been largely successful in HIV, but more complex genetic associations involving haplotypic or epigenetic variation, for example, remain elusive. Mechanistic insights explaining SNP associations are incomplete, but continue to be forthcoming. The number of robust immunogenetic correlates of HIV is modest and their discovery mostly predates the genome-wide era...
August 2017: Immunogenetics
https://www.readbyqxmd.com/read/28695281/foreword-immunogenetics-special-issue-2017
#8
EDITORIAL
Ronald E Bontrop
No abstract text is available yet for this article.
July 10, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28686681/kir-and-their-hla-class-i-ligands-two-more-pieces-towards-completing-the-puzzle-of-chronic-rejection-and-graft-loss-in-kidney-transplantation
#9
Roberto Littera, Gianbenedetto Piredda, Davide Argiolas, Sara Lai, Elena Congeddu, Paola Ragatzu, Maurizio Melis, Elisabetta Carta, Maria Benigna Michittu, Donatella Valentini, Luisella Cappai, Rita Porcella, Francesco Alba, Maria Serra, Valentina Loi, Roberta Maddi, Sandro Orrù, Giorgio La Nasa, Giovanni Caocci, Roberto Cusano, Marcella Arras, Mauro Frongia, Antonello Pani, Carlo Carcassi
BACKGROUND: Kidney transplantation is a life-saving treatment for patients with end-stage renal disease. However, despite progress in surgical techniques and patient management, immunological rejection continues to have a negative impact on graft function and overall survival. Incompatibility between donors and recipients for human leukocyte antigens (HLA) of the major histocompatibility complex (MHC) generates a series of complex cellular and humoral immune response mechanisms that are largely responsible for rejection and loss of graft function...
2017: PloS One
https://www.readbyqxmd.com/read/28680339/exceptional-manifestation-of-polyautoimmunity-in-a-very-young-girl-a-case-report
#10
Agnieszka Mroczkowska-Juchkiewicz, Jacek Postępski, Edyta Olesińska, Paulina Krawiec, Elżbieta Pac-Kożuchowska
Polyautoimmunity is defined as the presence of more than one autoimmune disease in a single patient. The exact pathogenic mechanisms responsible for the coexistence of distinct autoimmune diseases within an individual have not been clearly explained. We report a case of a very young girl with the extremely rare co-existence of four distinct autoimmune diseases i.e. juvenile idiopathic arthritis, type 1 diabetes mellitus, coeliac disease and autoimmune hepatitis, recognized based on validated international classification criteria...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28677168/impact-of-hla-drb1-allele-polymorphisms-on-control-of-hiv-infection-in-a-peruvian-msm-cohort
#11
B Oriol-Tordera, A Llano, C Ganoza, S Cate, W Hildebrand, J Sanchez, M L Calle, C Brander, A Olvera
Associations between HLA class II polymorphisms and HIV control were assessed in a Peruvian MSM cohort. Among 233 treatment naïve HIV+ individuals, DRB1*13:02 was linked to elevated viral loads (P = .044) while DRB1*12:01 showed significantly lower viral set points (P = .015) and restricted a dominant T cell response to HIV Gag p24 (P = .038). The present work contributes to a better knowledge of the Peruvian immunogenetics and supports the important role of HLA class II restricted T cells in HIV control...
July 5, 2017: HLA
https://www.readbyqxmd.com/read/28675059/immunogenetic-predisposing-factors-for-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis
#12
Bárbara Leal, João Chaves, Cláudia Carvalho, Andreia Bettencourt, Cláudia Brito, Daniela Boleixa, Joel Freitas, Sandra Brás, João Lopes, João Ramalheira, Paulo P Costa, Berta Martins da Silva, António Martins da Silva
PURPOSE: Neuroinflammation appears as an important epileptogenic mechanism. Experimental and clinical studies have demonstrated an upregulation of pro-inflammatory cytokines such as IL-1β and TNF-α, in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS). Expression of these cytokines can be modulated by polymorphisms such as rs16944 and rs1800629, respectively, both of which have been associated with Febrile Seizures (FS) and MTLE-HS development. The Human Leukocyte Antigen (HLA) system has also been implicated in diverse epileptic entities suggesting a variable role of this system in epilepsy...
July 4, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28673752/polymorphisms-in-immune-inflammatory-response-genes-and-the-risk-of-deficit-schizophrenia
#13
Monika Mak, Błażej Misiak, Dorota Frydecka, Justyna Pełka-Wysiecka, Jolanta Kucharska-Mazur, Agnieszka Samochowiec, Przemysław Bieńkowski, Edyta Pawlak-Adamska, Lidia Karabon, Elżbieta Szmida, Paweł Skiba, Kamila Kotowicz, Patryk Piotrowski, Jan Aleksander Beszłej, Jerzy Samochowiec
Polymorphisms in immune-inflammatory response genes are believed to impact schizophrenia susceptibility. However, it remains unknown whether immunogenetic factors play a role in the etiology of deficit schizophrenia (D-SCZ). Therefore, we genotyped four polymorphisms in genes encoding two immune system regulatory proteins (CTLA-4 rs231775 and CD28 rs3116496), interleukin-6 (IL6 rs1800795) and transforming growth factor-β (TGFB1 rs1800470) in 513 schizophrenia patients and 374 controls. The CD28 rs3116496-CC genotype and C-allele were significantly more frequent in the whole group of patients and D-SCZ patients compared to controls...
June 30, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28670765/publication-ethos-in-the-immunogenetics-community
#14
EDITORIAL
D Middleton, A B Hahn, S G E Marsh
No abstract text is available yet for this article.
August 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28663207/is-it-possible-to-develop-a-universal-influenza-virus-vaccine-immunogenetic-considerations-underlying-b-cell-biology-in-the-development-of-a-pan-subtype-influenza-a-vaccine-targeting-the-hemagglutinin-stem
#15
Sarah F Andrews, Barney S Graham, John R Mascola, Adrian B McDermott
Current influenza vaccines preferentially generate B-cell responses to the variable hemagglutinin (HA) head. Focusing vaccine-induced antibody responses on epitopes in the conserved HA stem may provide better protection against future drifted and pandemic strains. Understanding the basis for the dominant HA head and subdominant HA stem-specific responses at the level of B-cell activation and differentiation will be critical for designing vaccines that induce sustained stem-specific responses. Identifying antibody lineages with broad neutralizing activity against influenza A viruses and defining the structural mode of recognition for germline precursors of those antibodies will also guide future immunogen design...
June 29, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28654443/application-and-interpretation-of-histocompatibility-data-in-thoracic-heart-and-lung-transplantation
#16
Kelly H Schlendorf, Ashish S Shah
PURPOSE OF REVIEW: The purpose of the review is to update our current understanding and utilization of immunogenetic tools in heart and lung transplant. RECENT FINDINGS: Increasingly, complex patients have been managed perioperatively for heart and lung transplant using a variety of tests and techniques. Recent treatment regimens and listing strategies have exploited recent laboratory advances. However, the better characterization has led to an even more complex description of sensitized heart and lung candidates...
August 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28653187/virus-host-gene-interactions-define-hiv-1-disease-progression
#17
Daniela C Monaco, Zachary Ende, Eric Hunter
In this chapter, we will review recent research on the virology of HIV-1 transmission and the impact of the transmitted virus genotype on subsequent disease progression. In most instances of HIV-1 sexual transmission, a single genetic variant, or a very limited number of variants from the diverse viral quasi-species present in the transmitting partner establishes systemic infection. Transmission involves both stochastic and selective processes, such that in general a minority variant in the donor is transmitted...
June 27, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28651553/ig-and-tr-single-chain-fragment-variable-scfv-sequence-analysis-a-new-advanced-functionality-of-imgt-v-quest-and-imgt-highv-quest
#18
Véronique Giudicelli, Patrice Duroux, Sofia Kossida, Marie-Paule Lefranc
BACKGROUND: IMGT®, the international ImMunoGeneTics information system® ( http://www.imgt.org ), was created in 1989 in Montpellier, France (CNRS and Montpellier University) to manage the huge and complex diversity of the antigen receptors, and is at the origin of immunoinformatics, a science at the interface between immunogenetics and bioinformatics. Immunoglobulins (IG) or antibodies and T cell receptors (TR) are managed and described in the IMGT® databases and tools at the level of receptor, chain and domain...
June 26, 2017: BMC Immunology
https://www.readbyqxmd.com/read/28645875/high-resolution-igh-repertoire-analysis-reveals-fetal-liver-as-the-likely-origin-of-life-long-innate-b-lymphopoiesis-in-humans
#19
Anindita Roy, Vojtech Bystry, Georg Bohn, Katerina Goudevenou, Tomas Reigl, Maria Papaioannou, Adam Krejci, Sorcha O'Byrne, Aristeidis Chaidos, Andrea Grioni, Nikos Darzentas, Irene A G Roberts, Anastasios Karadimitris
The ontogeny of the natural, public IgM repertoire remains incompletely explored. Here, high-resolution immunogenetic analysis of B cells from (unrelated) fetal, child, and adult samples, shows that although fetal liver (FL) and bone marrow (FBM) IgM repertoires are equally diversified, FL is the main source of IgM natural immunity during the 2nd trimester. Strikingly, 0.25% of all prenatal clonotypes, comprising 18.7% of the expressed repertoire, are shared with the postnatal samples, consistent with persisting fetal IgM+ B cells being a source of natural IgM repertoire in adult life...
June 20, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28632323/clinical-outcomes-of-hla-dpb1-mismatches-in-10-10-hla-matched-unrelated-donor-recipient-pairs-undergoing-allogeneic-stem-cell-transplant
#20
Ann M Moyer, Shahrukh K Hashmi, Cynthia M Kroning, Walter K Kremers, Steven R De Goey, Mrinal Patnaik, Mark Litzow, Dennis A Gastineau, William J Hogan, Eapen K Jacob, Justin D Kreuter, Laurie L Wakefield, Manish J Gandhi
OBJECTIVE: HLA-DPB1 matching may impact allogeneic hematopoietic stem cell transplantation (ASCT) outcomes; however, this locus is not in linkage disequilibrium with the remainder of the HLA genes. After classifying HLA-DPB1 mismatches based on T-cell epitope, avoiding non-permissive mismatches may impact survival. We tested this hypothesis at a single academic institution. METHODS: Retrospective HLA-DPB1 genotyping was performed on 153 adult patients who underwent ASCT and unrelated donors matched for HLA-A, B, C, DRB1, and DQB1 loci (10/10)...
June 20, 2017: European Journal of Haematology
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