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Immunogenetics

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https://www.readbyqxmd.com/read/28280748/cervical-carcinogenesis-and-immune-response-gene-polymorphisms-a-review
#1
REVIEW
Akash M Mehta, Merel Mooij, Ivan Branković, Sander Ouburg, Servaas A Morré, Ekaterina S Jordanova
The local immune response is considered a key determinant in cervical carcinogenesis after persistent infection with oncogenic, high-risk human papillomavirus (HPV) infections. Genetic variation in various immune response genes has been shown to influence risk of developing cervical cancer, as well as progression and survival among cervical cancer patients. We reviewed the literature on associations of immunogenetic single nucleotide polymorphism, allele, genotype, and haplotype distributions with risk and progression of cervical cancer...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28271567/the-welsh-blood-service-70-years-of-continuous-change
#2
REVIEW
G D Poole
The National Blood Transfusion Service (NBTS) in England and Wales was established as a single entity in 1946 and operated as such for almost half a century. During those 50 years, the blood service in Wales, as in the rest of the UK, saw many technological and operational changes. The automation of donation testing, the introduction of successive layers of microbiological screening, the creation of the Tissue Typing Laboratory (later renamed the Welsh Transplantation and Immunogenetics Laboratory) and the development of information technology brought - over a relatively long period - highly significant improvements to an organisation that had begun life as an Emergency Medical Service...
March 8, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28270810/a-novel-model-on-dst-induced-transplantation-tolerance-by-the-transfer-of-self-specific-donor-ttregs-to-a-haplotype-matched-organ-recipient
#3
Angelica Maria Mohr Gregoriussen, Henrik Georg Bohr
Donor-specific blood transfusion (DST) can lead to significant prolongation of allograft survival in experimental animal models and sometimes human recipients of solid organs. The mechanisms responsible for the beneficial effect on graft survival have been a topic of research and debate for decades and are not yet fully elucidated. Once we discover how the details of the mechanisms involved are linked, we could be within reach of a procedure making it possible to establish donor-specific tolerance with minimal or no immunosuppressive medication...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28244954/increased-hiv-1-superinfection-risk-in-carriers-of-specific-human-leukocyte-antigen-alleles
#4
Jouni Vesa, Antoine Chaillon, Gabriel A Wagner, Christy M Anderson, Douglas D Richman, Davey M Smith, Susan J Little
OBJECTIVE: To characterize the demographic, behavioral, clinical, and immunogenetic determinants of HIV-1 superinfection (SI) in a high-risk cohort of men who have sex with men (MSM). DESIGN: Retrospective cohort study of prospectively followed MSM. METHODS: Ninety-eight MSM with acute or early HIV-1 monoinfection (MI) were followed for a median of 15.6 months. Demographic and human leukocyte antigen (HLA) genotype data were collected at enrollment...
February 27, 2017: AIDS
https://www.readbyqxmd.com/read/28225833/influence-of-hla-class-i-hla-class-ii-and-kirs-on-vertical-transmission-and-chronicity-of-hepatitis-c-virus-in-children
#5
A Ruiz-Extremera, E J Pavón-Castillero, M Florido, P Muñoz de Rueda, J A Muñoz-Gámez, J Casado, A Carazo, R Quiles, S M Jiménez-Ruiz, A Gila, J D Luna, J León, J Salmerón
BACKGROUND & AIM: There is evidence that maternal viral load of HCV during delivery influences the risk for Mother-to-child transmission (MTCT), but this does not explain all cases. We study the role of the immunogenetic profile (HLA, KIRs and KIR-ligand binding) of mothers and children in HCV-MTCT and in chronicity in the children. METHODOLOGY: 79 HCV-RNA (+) mothers and their 98 children were included. 24 children were infected, becoming chronic in 8 cases and clearing in 16...
2017: PloS One
https://www.readbyqxmd.com/read/28220663/three-new-hla-alleles-b-49-43-c-03-321-and-dqb1-02-72
#6
J Street, L Williams, T Climer, C Harvey, C Darke
Immunogenetic information is provided on 3 novel HLA-B, -C and -DQB1 alleles.
April 2017: HLA
https://www.readbyqxmd.com/read/28214377/reciprocal-translocation-of-small-numbers-of-inbred-individuals-rescues-immunogenetic-diversity
#7
Catherine E Grueber, Jolene T Sutton, Sol Heber, James V Briskie, Ian G Jamieson, Bruce C Robertson
Genetic rescue can reduce inbreeding depression and increase fitness of small populations, even when the donor populations are highly inbred. In a recent experiment involving two inbred island populations of the New Zealand South Island robin, Petroica australis, reciprocal translocations improved microsatellite diversity and individual fitness. While microsatellite loci may reflect patterns of genome-wide diversity, they generally do not indicate the specific genetic regions responsible for increased fitness...
February 18, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28195089/immunogenetics-of-chronic-lymphocytic-leukemia
#8
Nikhil Patkar, Nikhil Rabade, Pratibha Amare Kadam, Falguni Mishra, Aditi Muranjan, Prashant Tembhare, Shruti Chaudhary, Swapnali Joshi, Hasmukh Jain, Uma Dangi, Bhausaheb Bagal, Navin Khattry, Hari Menon, Sumeet Gujral, Manju Sengar, P G Subramanian
INTRODUCTION: Cytogenetic aberrations as well as presence of IGVH mutations are the underlying reason for clinical heterogeneity in Chronic Lymphocytic Leukemia (CLL). The presence of IGVH mutations as well as the predominant gene usage shows geographical variations. However, there is no study from India addressing immunogenetics of CLL. In a first Indian study we document the immunogenetics of CLL in a large tertiary hospital. METHODS: We analyzed IGVH mutation status, VH gene usage, cytogenetic abnormalities using FISH, immunophenotyping data and correlated them with standard clinical variables in 84 patients of CLL...
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28176894/autoimmune-hepatitis-current-challenges-and-future-prospects
#9
REVIEW
Yoshio Aizawa, Atsushi Hokari
Autoimmune hepatitis (AIH) is a chronic progressive liver disease characterized by high levels of aminotransferases and autoantibodies, hypergammaglobulinemia, and interface hepatitis. AIH affects all races and all ages worldwide, regardless of sex, although a preponderance of females is a constant finding. The etiology of AIH has not been completely elucidated, but immunogenetic background and environmental parameters may contribute to its development. The most important genetic factor is human leukocyte antigens (HLAs), especially HLA-DR, whereas the role of environmental factors is not completely understood...
2017: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/28150864/web-sites-of-interest-to-immunologists
#10
Marie-Paule Lefranc
This appendix includes a selection of links of interest to immunologists from the international ImMunoGeneTics (IMGT) database, covering a wide variety of subject matter. © 2017 by John Wiley & Sons, Inc.
February 2, 2017: Current Protocols in Immunology
https://www.readbyqxmd.com/read/28146446/immunogenetics-in-primary-sclerosing-cholangitis
#11
Brian K Chung, Gideon M Hirschfield
PURPOSE OF REVIEW: Primary sclerosing cholangitis (PSC) is a progressive biliary liver disorder strongly associated with inflammatory bowel disease (PSC-IBD). We summarize the genetics of PSC-IBD and highlight recent findings that further differentiate PSC-IBD as a unique disease. RECENT FINDINGS: To date, genome-wide studies have uncovered 23 susceptibility loci for PSC-IBD, the majority of which have been previously reported as risk factors in other immune-mediated disorders...
March 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28127443/the-unusual-association-of-inverse-retinitis-pigmentosa-and-fuchs-heterochromic-iridocyclitis
#12
Gian Franco Díez-Cattini, David Arturo Ancona-Lezama, Carlos Valdés-Lara, Virgilio Morales-Cantón
BACKGROUND: Classic retinitis pigmentosa (RP) and other syndromic variants have previously been associated to Fuchs' heterochromic iridocyclitis (FHI). Common immunogenic and inflammatory pathways have been proposed to explain the higher incidence of this uveitic phenomenon in patients with retinal dystrophies without definitive answers. Infrequent variants of RP such as inverse RP have not been previously reported in association with FHI. We believe that finding the way these entities connect can shed some light into their complex pathogenesis and help find ways to foresee and prevent the appearance of complications such as cataract and macular edema...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28110690/improved-cognitive-and-memory-abilities-in-a-patient-with-alzheimer-s-disease-treated-with-activated-immune-cells-immune-cell-therapy-may-benefit-more-ad-patients
#13
B Laumbacher, B Fellerhoff-Loesch, R Wank
So far, the pathogenesis of Alzheimer's disease (AD) has not been clarified, nor has patient therapy been satisfactory. Although inheritance dominates the less frequent early-onset AD in young and middle-aged individuals, environmental and immunogenetic factors have been identified in the most frequently occurring late-onset AD of higher-aged individuals, comprising 90% of AD patients. Thorough investigations have detected a prevalence of certain microbes which are known to affect brain activities in the brains of AD patients...
February 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28110360/proceedings-of-the-10th-jubilee-east-west-immunogenetics-conference-on-april-21-23-2016-wroc%C3%A5-aw-poland
#14
(no author information available yet)
No abstract text is available yet for this article.
January 21, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28102034/common-and-well-documented-hla-alleles-over-all-of-europe-and-within-european-sub-regions-a-catalogue-from-the-european-federation-for-immunogenetics
#15
A Sanchez-Mazas, J M Nunes, D Middleton, J Sauter, S Buhler, A McCabe, J Hofmann, D M Baier, A H Schmidt, G Nicoloso, M Andreani, Z Grubic, J-M Tiercy, K Fleischhauer
BACKGROUND: A catalogue of common and well-documented (CWD) human leukocyte antigen (HLA), previously established by the American Society for Histocompatibility and Immunogenetics (ASHI), is widely used as indicator for typing ambiguities to be resolved in tissue transplantation or for checking the universality of any HLA allele in the world. However, European population samples, which are characterized by a substantial level of genetic variation, are underrepresented in the ASHI catalogue...
February 2017: HLA
https://www.readbyqxmd.com/read/28100171/genome-wide-standing-variation-facilitates-long-term-response-to-bidirectional-selection-for-antibody-response-in-chickens
#16
Mette Lillie, Zheya Sheng, Christa F Honaker, Ben J Dorshorst, Christopher M Ashwell, Paul B Siegel, Örjan Carlborg
BACKGROUND: Long-term selection experiments provide a powerful approach to gain empirical insights into adaptation, allowing researchers to uncover the targets of selection and infer their contributions to the mode and tempo of adaptation. Here we implement a pooled genome re-sequencing approach to investigate the consequences of 39 generations of bidirectional selection in White Leghorn chickens on a humoral immune trait: antibody response to sheep red blood cells. RESULTS: We observed wide genome involvement in response to this selection regime...
January 18, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28067621/cohort-profile-the-finnish-genetics-of-pre-eclampsia-consortium-finnpec
#17
Tiina Jääskeläinen, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Hannele Laivuori
PURPOSE: The Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) Study was established to set up a nationwide clinical and DNA database on women with and without pre-eclampsia (PE), including their partners and infants, in order to identify genetic risk factors for PE. PARTICIPANTS: FINNPEC is a cross-sectional case-control cohort collected from 5 university hospitals in Finland during 2008-2011. A total of 1450 patients with PE and 1065 pregnant control women without PE (aged 18-47 years) were recruited...
November 10, 2016: BMJ Open
https://www.readbyqxmd.com/read/28067566/basic-concepts-in-kidney-transplant-immunology
#18
REVIEW
Roberta Callus, Jesmar Buttigieg, Andrei Agius Anastasi, Ahmed Halawa
Advances in the field of immunohistocompatibility and immunogenetics have been crucial for improvements in kidney transplant outcomes. This review provides a practical outline of these important breakthroughs for the general physician, at a time when demand for kidney transplants is increasing.
January 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28043521/interleukin-10-gene-polymorphism-is-associated-with-multi-drug-resistant-tuberculosis-during-the-intensive-phase-of-standard-chemotherapy
#19
Butov Dmytro, Kuzhko Mykhailo, Butova Tetyana Kuzhko
OBJECTIVE/BACKGROUND: To study whether interleukin (IL)-10 gene polymorphism is associated with multi-drug resistant tuberculosis (MDR TB) during the intensive phase of standard chemotherapy. METHODS: The study comprised 170 individuals in Kharkiv region of Ukraine including 74 patients with pulmonary MDR TB (Group 1), 66 patients without MDR TB (Group 2), and 30 healthy donors (Group 3). Serum level of IL-10 was evaluated by enzyme-linked immunosorbent assay (pg/L)...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28036301/itpr3-gene-haplotype-is-associated-with-cervical-squamous-cell-carcinoma-risk-in-taiwanese-women
#20
Yuh-Cheng Yang, Tzu-Yang Chang, Tze-Chien Chen, Wen-Shan Lin, Shih-Chuan Chang, Yann-Jinn Lee
Host immunogenetic background plays an important role in human papillomavirus (HPV) infection and cervical cancer development. Inositol 1,4,5-triphosphate receptor type 3 (ITPR3) is essential for both immune activation and cancer pathogenesis. We aim to investigate if ITPR3 genetic polymorphisms are associated with the risk of cervical cancer in Taiwanese women. ITPR3 rs3748079 A/G and rs2229634 C/T polymorphisms were genotyped in a hospital-based study of 462 women with cervical squamous cell carcinoma (CSCC) and 921 age-matched healthy control women...
February 7, 2017: Oncotarget
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