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Immunogenetics

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https://www.readbyqxmd.com/read/28892161/a-gene-is-known-by-the-company-it-keeps-enrichment-of%C3%A2-tnfaip3%C3%A2-gene-aberrations-in-malt-lymphomas-expressing-ighv4-34-antigen-receptors
#1
Andreas Agathangelidis, Aliki Xochelli, Kostas Stamatopoulos
Associations between immunoglobulin (IG) receptors with distinctive immunogenetic features and particular gene mutations is a recurring theme in mature B cell lymphomas. Relevant observations have been made in chronic lymphocytic leukemia (CLL), where gene mutations are distributed asymmetrically in cases bearing or not somatic hypermutations within the clonotypic immunoglobulin heavy chain variable region (IGHV) genes (e.g. TP53 mutations predominate in IG-unmutated CLL, whereas the opposite is seen for MYD88 mutations, enriched in IG-mutated CLL) and in subsets of cases with stereotyped IG (enrichment for SF3B1 mutations in CLL subset #2)...
September 11, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28867280/interaction-between-childhood-maltreatment-on-immunogenetic-risk-in-depression-discovery-and-replication-in-clinical-case-control-samples
#2
S Cohen-Woods, H L Fisher, D Ahmetspahic, K Douroudis, D Stacey, G M Hosang, A Korszun, M Owen, N Craddock, V Arolt, U Dannowski, G Breen, I W Craig, A Farmer, B T Baune, C M Lewis, R Uher, P McGuffin
Major depressive disorder (MDD) is a prevalent disorder with moderate heritability. Both MDD and interpersonal adversity, including childhood maltreatment, have been consistently associated with elevated inflammatory markers. We investigated interaction between exposure to childhood maltreatment and extensive genetic variation within the inflammation pathway (CRP, IL1b, IL-6, IL11, TNF, TNFR1, and TNFR2) in relation to depression diagnosis. The discovery RADIANT sample included 262 cases with recurrent DSM-IV/ICD-10 MDD, and 288 unaffected controls...
August 31, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28842944/high-throughput-next-generation-sequencing-to-genotype-six-classical-hla-loci-from-96-donors-in-a-single-miseq-run
#3
Philip K Ehrenberg, Aviva Geretz, Ravi Kumar Sindhu, Tamara Vayntrub, Marcelo A Fernández Viña, Richard Apps, Nelson Michael, Rasmi Thomas
Next Generation Sequencing (NGS) methods have been established as an efficient approach for HLA typing because unlike traditional Sanger sequencing, they provide unambiguous results at a reasonable cost. We previously developed a multi-locus index method to genotype four HLA loci (A, B, C, and DRB1) on the Illumina MiSeq platform. We have now expanded this method to include two additional loci, HLA-DPB1 and DQB1. Contiguous full-length amplicons from 5'UTR through 3'UTR regions were generated using one long-range PCR reaction per locus for each of the six loci from 96 individuals of different ethnicities...
August 25, 2017: HLA
https://www.readbyqxmd.com/read/28832904/infectious-and-immunogenetic-factors-in-bipolar-disorder
#4
REVIEW
J Oliveira, A J Oliveira-Maia, R Tamouza, A S Brown, M Leboyer
OBJECTIVE: Despite the evidence supporting the association between infection and bipolar disorder (BD), the genetic vulnerability that mediates its effects has yet to be clarified. A genetic origin for the immune imbalance observed in BD, possibly involved in the mechanisms of pathogen escape, has, however, been suggested in recent studies. METHOD: Here, we present a critical review based on a systematic literature search of articles published until December 2016 on the association between BD and infectious/immunogenetic factors...
August 20, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28830602/human-leukocyte-antigen-allele-linkage-disequilibrium-and-haplotype-structure-in-volunteer-bone-marrow-donors-of-paran%C3%A3-state
#5
Paulo Rincoski Costantino, Suelen Camargo Zeck, Waldir Antonio da Silva, Maria da Graça Bicalho
BACKGROUND: Bone marrow transplantation has been used in the treatment of various diseases, especially hematologic diseases. The success of this treatment, among other factors, requires human leukocyte antigens (HLA) compatibility between patient and donor. Knowing the human leukocyte antigens allele group and haplotype frequencies as well as the linkage disequilibrium between alleles of different human leukocyte antigens loci can shorten the search time for a compatible bone marrow donor...
July 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/28811194/immunogenetic-studies-of-the-hepatitis-c-virus-infection-in-an-era-of-pan-genotype-antiviral-therapies-effective-treatment-is-coming
#6
Joel Henrique Ellwanger, Valéria de Lima Kaminski, Jacqueline Maria Valverde-Villegas, Daniel Simon, Vagner Ricardo Lunge, José Artur Bogo Chies
What are the factors that influence human hepatitis C virus (HCV) infection, hepatitis status establishment, and disease progression? Firstly, one has to consider the genetic background of the host and HCV genotypes. The immunogenetic host profile will reflect how each infected individual deals with infection. Secondly, there are environmental factors that drive susceptibility or resistance to certain viral strains. These will dictate (I) the susceptibility to infection; (II) whether or not an infected person will promote viral clearance; (III) the immune response and the response profile to therapy; and (IV) whether and how long it would take to the development of HCV-associated diseases, as well as their severity...
August 12, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28768193/immunogenetic-profiling-for-gastric-cancers-identifies-sulfated-glycosaminoglycans-as-major-and-functional-b-cell-antigens-in-human-malignancies
#7
Hiroto Katoh, Daisuke Komura, Hiroki Konishi, Ryohei Suzuki, Asami Yamamoto, Miwako Kakiuchi, Reiko Sato, Tetsuo Ushiku, Shogo Yamamoto, Kenji Tatsuno, Takashi Oshima, Sachiyo Nomura, Yasuyuki Seto, Masashi Fukayama, Hiroyuki Aburatani, Shumpei Ishikawa
Recent successes in tumor immunotherapies have highlighted the importance of tumor immunity. However, most of the work conducted to date has been on T cell immunity, while the role of B cell immunity in cancer remains more elusive. In this study, immunogenetic repertoire profiling for tumor-infiltrating B and T cells in gastric cancers was carried out to help reveal the architecture of B cell immunity in cancer. Humoral immunity in cancer was shown to involve oligoclonal expansions of tumor-specific and private B cell repertoires...
August 1, 2017: Cell Reports
https://www.readbyqxmd.com/read/28765516/next-generation-sequencing-in-chronic-lymphocytic-leukemia-recent-findings-and-new-horizons
#8
REVIEW
Ana E Rodríguez-Vicente, Vasilis Bikos, María Hernández-Sánchez, Jitka Malcikova, Jesús-María Hernández-Rivas, Sarka Pospisilova
The rapid progress in next-generation sequencing technologies has significantly contributed to our knowledge of the genetic events associated with the development, progression and treatment resistance of chronic lymphocytic leukemia patients. Together with the discovery of new driver mutations, next-generation sequencing has revealed an immense degree of both intra- and inter-tumor heterogeneity and enabled us to describe marked clonal evolution. Advances in immunogenetics may be implemented to detect minimal residual disease more sensitively and to track clonal B cell populations, their dynamics and molecular characteristics...
July 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28755388/kir-on-the-cusp%C3%A2-of%C3%A2-modern-immunogenetics
#9
REVIEW
Francesco Colucci, James Traherne
Killer Immunoglobulin-like Receptors (KIR) and their Human Leukocyte Antigen (HLA) ligands play a central role in immunity and human health. These molecules are encoded by gene families with copy number variation, extreme levels of sequence diversity and complex expression patterns. The rapid evolution of KIR and HLA genes and their associations with infectious diseases, pregnancy disorders, immunopathologies and outcome of cell transplantation has generated considerable interest from immunologists, geneticists and clinicians...
July 29, 2017: Immunology
https://www.readbyqxmd.com/read/28743384/publication-ethos-in-the-immunogenetics-community
#10
EDITORIAL
Amy B Hahn, Steven G E Marsh, Derek Middleton
No abstract text is available yet for this article.
July 2017: Human Immunology
https://www.readbyqxmd.com/read/28695290/major-histocompatibility-complex-variation-and-the-evolution-of-resistance-to-amphibian-chytridiomycosis
#11
REVIEW
Minjie Fu, Bruce Waldman
Chytridiomycosis, caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), has been implicated in population declines and species extinctions of amphibians around the world. Susceptibility to the disease varies both within and among species, most likely attributable to heritable immunogenetic variation. Analyses of transcriptional expression in hosts following their infection by Bd reveal complex responses. Species resistant to Bd generally show evidence of stronger innate and adaptive immune system responses...
July 10, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28695288/introduction-mhc-kir-and-governance-of-specificity
#12
REVIEW
Adrian Kelly, John Trowsdale
The MHC controls specificity, to ensure that appropriate immune responses are mounted to invading pathogens whilst maintaining tolerance to the host. It encodes molecules that act as sentinels, providing a snapshot of the health of the interior and exterior of the cell for immune surveillance. To maintain the ability to respond appropriately to any disease requires a delicate balance of expression and function, and many subtleties of the system have been described at the gene, individual and population level...
August 2017: Immunogenetics
https://www.readbyqxmd.com/read/28695282/host-genetic-variation-and-hiv-disease-from-mapping-to-mechanism
#13
REVIEW
Vivek Naranbhai, Mary Carrington
This review aims to provide a summary of current knowledge of host genetic effects on human immunodeficiency virus (HIV) disease. Mapping of simple single nucleotide polymorphisms (SNP) has been largely successful in HIV, but more complex genetic associations involving haplotypic or epigenetic variation, for example, remain elusive. Mechanistic insights explaining SNP associations are incomplete, but continue to be forthcoming. The number of robust immunogenetic correlates of HIV is modest and their discovery mostly predates the genome-wide era...
August 2017: Immunogenetics
https://www.readbyqxmd.com/read/28695281/foreword-immunogenetics-special-issue-2017
#14
EDITORIAL
Ronald E Bontrop
No abstract text is available yet for this article.
July 10, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28686681/kir-and-their-hla-class-i-ligands-two-more-pieces-towards-completing-the-puzzle-of-chronic-rejection-and-graft-loss-in-kidney-transplantation
#15
Roberto Littera, Gianbenedetto Piredda, Davide Argiolas, Sara Lai, Elena Congeddu, Paola Ragatzu, Maurizio Melis, Elisabetta Carta, Maria Benigna Michittu, Donatella Valentini, Luisella Cappai, Rita Porcella, Francesco Alba, Maria Serra, Valentina Loi, Roberta Maddi, Sandro Orrù, Giorgio La Nasa, Giovanni Caocci, Roberto Cusano, Marcella Arras, Mauro Frongia, Antonello Pani, Carlo Carcassi
BACKGROUND: Kidney transplantation is a life-saving treatment for patients with end-stage renal disease. However, despite progress in surgical techniques and patient management, immunological rejection continues to have a negative impact on graft function and overall survival. Incompatibility between donors and recipients for human leukocyte antigens (HLA) of the major histocompatibility complex (MHC) generates a series of complex cellular and humoral immune response mechanisms that are largely responsible for rejection and loss of graft function...
2017: PloS One
https://www.readbyqxmd.com/read/28680339/exceptional-manifestation-of-polyautoimmunity-in-a-very-young-girl-a-case-report
#16
Agnieszka Mroczkowska-Juchkiewicz, Jacek Postępski, Edyta Olesińska, Paulina Krawiec, Elżbieta Pac-Kożuchowska
Polyautoimmunity is defined as the presence of more than one autoimmune disease in a single patient. The exact pathogenic mechanisms responsible for the coexistence of distinct autoimmune diseases within an individual have not been clearly explained. We report a case of a very young girl with the extremely rare co-existence of four distinct autoimmune diseases i.e. juvenile idiopathic arthritis, type 1 diabetes mellitus, coeliac disease and autoimmune hepatitis, recognized based on validated international classification criteria...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28677168/impact-of-hla-drb1-allele-polymorphisms-on-control-of-hiv-infection-in-a-peruvian-msm-cohort
#17
B Oriol-Tordera, A Llano, C Ganoza, S Cate, W Hildebrand, J Sanchez, M L Calle, C Brander, A Olvera
Associations between HLA class II polymorphisms and HIV control were assessed in a Peruvian MSM cohort. Among 233 treatment naïve HIV+ individuals, DRB1*13:02 was linked to elevated viral loads (P = .044) while DRB1*12:01 showed significantly lower viral set points (P = .015) and restricted a dominant T cell response to HIV Gag p24 (P = .038). The present work contributes to a better knowledge of the Peruvian immunogenetics and supports the important role of HLA class II restricted T cells in HIV control...
July 5, 2017: HLA
https://www.readbyqxmd.com/read/28675059/immunogenetic-predisposing-factors-for-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis
#18
Bárbara Leal, João Chaves, Cláudia Carvalho, Andreia Bettencourt, Cláudia Brito, Daniela Boleixa, Joel Freitas, Sandra Brás, João Lopes, João Ramalheira, Paulo P Costa, Berta Martins da Silva, António Martins da Silva
PURPOSE: Neuroinflammation appears as an important epileptogenic mechanism. Experimental and clinical studies have demonstrated an upregulation of pro-inflammatory cytokines such as IL-1β and TNF-α, in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS). Expression of these cytokines can be modulated by polymorphisms such as rs16944 and rs1800629, respectively, both of which have been associated with Febrile Seizures (FS) and MTLE-HS development. The Human Leukocyte Antigen (HLA) system has also been implicated in diverse epileptic entities suggesting a variable role of this system in epilepsy...
July 4, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28673752/polymorphisms-in-immune-inflammatory-response-genes-and-the-risk-of-deficit-schizophrenia
#19
Monika Mak, Błażej Misiak, Dorota Frydecka, Justyna Pełka-Wysiecka, Jolanta Kucharska-Mazur, Agnieszka Samochowiec, Przemysław Bieńkowski, Edyta Pawlak-Adamska, Lidia Karabon, Elżbieta Szmida, Paweł Skiba, Kamila Kotowicz, Patryk Piotrowski, Jan Aleksander Beszłej, Jerzy Samochowiec
Polymorphisms in immune-inflammatory response genes are believed to impact schizophrenia susceptibility. However, it remains unknown whether immunogenetic factors play a role in the etiology of deficit schizophrenia (D-SCZ). Therefore, we genotyped four polymorphisms in genes encoding two immune system regulatory proteins (CTLA-4 rs231775 and CD28 rs3116496), interleukin-6 (IL6 rs1800795) and transforming growth factor-β (TGFB1 rs1800470) in 513 schizophrenia patients and 374 controls. The CD28 rs3116496-CC genotype and C-allele were significantly more frequent in the whole group of patients and D-SCZ patients compared to controls...
June 30, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28670765/publication-ethos-in-the-immunogenetics-community
#20
EDITORIAL
D Middleton, A B Hahn, S G E Marsh
No abstract text is available yet for this article.
August 2017: International Journal of Immunogenetics
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