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https://www.readbyqxmd.com/read/28144727/-non-vitamin-k-dependent-oral-anticoagulants-what-is-important-in-intensive-care-medicine
#1
D C Gulba, L Broscaru
Since first used in 2009, non-vitamin K oral anticoagulants (NOAC) have gained world-wide acceptance. Two groups of NOAC are currently used: the direct thrombin antagonist dabigatran and three direct factor  Xa antagonists apixaban, edoxaban, and ricaroxaban. With their increasing use for prevention of thromboembolism, the probability increases that NOAC-pretreated patients are admitted to emergency departments or intensive care units.The clinical challenge in NOAC preanticoagulated patients is to adequately cope with the given anticoagulated status of such patients...
January 31, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28079537/successful-total-hip-replacement-with-sequential-administration-of-bypassing-agents-in-an-adolescent-boy-with-hemophilia-a-and-high-inhibitor-titers
#2
Zühre Kaya, Özlem Orhan, Sacit Turanl, İdil Yenicesu, Ülker Koçak, Türkiz Gürsel
There are only a few reports of total hip replacement in patients with hemophilia A and inhibitors. We performed total hip replacement in an 18-year-old adolescent boy who had high inhibitor titers since infancy. Recombinant factor VIIa (NovoSeven) was used as a bypass agent during the surgery. There was no excessive introperative bleeding; however, postsurgical bleeding occurred and was controlled by sequential administration of recombinant factor VIIa and activated prothrombin complex concentrate (FEIBA)...
January 12, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28007364/factor-eight-inhibitor-bypassing-agent-feiba-for-reversal-of-target-specific-oral-anticoagulants-in-life-threatening-intracranial-bleeding
#3
Gordon Mao, Lauren King, Sarah Young, Richard Kaplan
INTRODUCTION: As increasing number of patients present to emergency departments with life threatening hemorrhages, particularly intracranial hemorrhage on anticoagulation physicians must be cognizant of the limitations of the available reversal options. Based upon the available literature, our institution formulated a reversal algorithm for patients with life-threatening bleeding on factor Xa inhibitors by administering factor eight inhibitor bypassing agent (FEIBA) 20 units/kg. METHODS: A retrospective chart review was performed to include all patients who received FEIBA per institutional protocol...
December 19, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27850486/848-urgent-doac-reversal-with-low-20-units-kg-or-moderate-dose-%C3%A2-20-units-kg-feiba-in-major-bleeding
#4
William Dager, Aaron Roberts, William Dager
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850258/619-use-of-activated-pcc-feiba-for-life-threatening-bleeding-associated-with-factor-xa-inhibitors
#5
Alicia Sacco, Sarah Young
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27795652/-antihemophilic-factor-is-not-the-only-answer-for-all-factor-viii-deficiencies-case-report-of-odontogenic-infection-in-a-patient-with-hemophilia-a-complicated-by-factor-viii-inhibitors-and-managed-by-transfusion-of-antihemophilic-factor-and-factor-viii-inhibitor
#6
K M Sudheesh, K S N Siva Bharani, H Y Kiran, Suresh Hanagavadi
Dental extraction in hemophiliacs with acquired inhibitors is always a risky procedure, which often presents a lot of problems associated with bleeding. A known case of hemophilia A complicated with factor VIII inhibitors and having odontogenic infection was successfully managed by transfusion of factor VIII inhibitor bypass activity (FEIBA) and antihemophilic factor. Past medical history was significant for multiple factor VIII transfusions. Bethesda assay done to identify inhibitors revealed low titer factor VIII inhibitors...
September 2016: Indian Journal of Dentistry
https://www.readbyqxmd.com/read/27642341/cost-effectiveness-analysis-of-biogeneric-recombinant-activated-factor-vii-aryoseven%C3%A2-and-activated-prothrombin-complex-concentrates-feiba%C3%A2-to-treat-hemophilia-a-patients-with-inhibitors-in-iran
#7
Mina Golestani, Peyman Eshghi, Hamid Reza Rasekh, Abdoll Majid Cheraghali, Jamshid Salamzadeh, Majid Naderi, Mohammad Reza Managhchi, Hamid Hoorfar, Gholam Reza Toogeh, Ali Imani, Mohammad Taghi Khodayari, Behnaz Habibpanah, Razieh Hantooshzadeh
Nowadays, bypassing agents such as recombinant activated factor VII (rFVIIa) and activated prothrombin complex concentrates (aPCC) are used to treat bleeding episodes in the Hemophilia patients with inhibitors. AryoSeven® is an Iranian biogeneric rFVIIa with homogeneity of efficacy and the nature to NovoSeven in a comparative trial. The current clinical trial aimed to evaluate the cost-effectiveness of FEIBA and AryoSeven® by Decision Analytic Model according to the Iranian healthcare system. An open label, multi-center, cross-over clinical trial was designed...
2016: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/27200453/-research-on-electrical-impedance-tomography-technology
#8
REVIEW
Feiba Chang, Hehua Zhang, Lexian Yan, Jun Yin
This article reviews the principle of electrical impedance tomography imaging and measurement system; focuses on electrical impedance tomography imaging detection system of incentive mode and several typical image reconstruction algorithm of electrical impedance imaging; and objectively compares and effectively evaluates several image reconstruction algorithm.
January 2016: Zhongguo Yi Liao Qi Xie za Zhi, Chinese Journal of Medical Instrumentation
https://www.readbyqxmd.com/read/26898225/rotem-monitoring-of-activated-and-non-activated-prothrombin-complex-concentrate-correction-of-dilutional-coagulopathy
#9
Olof Elvstam, Erik Berntorp, Ulf Schött
OBJECTIVES: Prothrombin complex concentrates have been used to correct dilutional coagulopathy, but many preparations contain anticoagulants, such as heparin, to counteract their prothrombotic effects. These anticoagulants can interfere with haemostatic assays. The aim of this study was to monitor two different prothrombin complex concentrates for the treatment of albumin dilution in vitro, using rotational thromboelastometry with or without the heparin-antagonising agent protamine. METHODS: Citrated blood from 10 healthy volunteers was, in vitro, diluted 1:1 with 5% albumin and then corrected with a four-factor prothrombin complex concentrate with heparin anticoagulant (Confidex®) corresponding to a clinical dose of 43 IU/kg...
2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/26879158/pro-and-anticoagulant-factors-facilitate-thrombin-generation-and-balance-the-haemostatic-response-to-feiba-%C3%A2-in-prophylactic-therapy
#10
K Varadi, S Tangada, M Loeschberger, P Montsch, G Schrenk, B Ewenstein, P L Turecek
INTRODUCTION: FEIBA(®) consists of zymogens and traces of activated forms of procoagulant factors II, VII, IX, X, anticoagulants protein C and TFPI, and small amounts of cofactors FV, FVIII and protein S, in a balanced ratio. As shown previously, FII-FXa complex plays a key role in FEIBA's mode of action (MoA). METHODS: Thrombin generation (TG) was measured by spiking coagulation factors, cofactors and inhibitors to high titer FVIII inhibitor plasma, and in plasma samples from patients in a phase 3 clinical study evaluating the safety and efficacy of FEIBA prophylaxis in haemophilia A patients with inhibitors...
July 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/26842562/spanish-consensus-guidelines-on-prophylaxis-with-bypassing-agents-in-patients-with-haemophilia-and-inhibitors
#11
Maria Fernanda López-Fernández, Carmen Altisent Roca, Maria Teresa Álvarez-Román, Mariana Isabel Canaro Hirnyk, Maria Eva Mingot-Castellano, Víctor Jiménez-Yuste, Ana Rosa Cid Haro, Rosario Pérez-Garrido, Carmen Sedano Balbas
Prophylaxis with the blood clotting factor, factor VIII (FVIII) is ineffective for individuals with haemophilia A and high-titre inhibitors to FVIII. Prophylaxis with the FVIII bypassing agents activated prothrombin complex concentrates (aPCC; FEIBA® Baxalta) or recombinant activated factor VII (rFVIIa; Novo-Seven®, Novo Nordisk) may be an effective alternative. It was our aim to develop evidence -and expert opinion- based guidelines for prophylactic therapy for patients with high-titre inhibitors to FVIII...
May 2, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/26829366/global-post-authorization-safety-surveillance-study-real-world-data-on-prophylaxis-and-on-demand-treatment-using-feiba-an-activated-prothrombin-complex-concentrate
#12
MULTICENTER STUDY
Claude Negrier, Sophie Voisin, Fariba Baghaei, Robert Numerof, Aaron Novack, Jennifer E Doralt, Vadim Romanov, Alessandro Gringeri
This prospective, Post-Authorization Safety Surveillance (PASS) study was carried out in patients with hemophilia A or B and inhibitors treated with FEIBA for 1 year to collect real-world data on safety and effectiveness of FEIBA. The study followed a cohort design and did not make stipulations on treatment or observation schedule, as it was designed to observe routine medical practices based on physicians' treatment decisions, including whether patients received on-demand or prophylaxis with FEIBA. The attending physician maintained documentation, including medical records, laboratory reports, adverse event reports, and so on and a subject diary was used...
July 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/26635073/recombinant-human-prothrombin-medi8111-prevents-bleeding-in-haemophilia-a-and-b-mice
#13
K M Hansson, A Lindblom, M Elg, A Lövgren
BACKGROUND: Haemophilia A and B are treated with FVIII and FIX replacement therapy. Treatment may be complicated by inhibitory antibodies that require bypass therapy such as FEIBA(®) in which prothrombin (FII) is suggested to be the main active component. METHODS: To evaluate the effect of FII on haemophilia recombinant human (rh) FII (MEDI8111) or plasma-derived human FII (pdhFII) was given as single doses to anaesthetized haemophilia A and B mice 3 min before tail transection and rhFVIII or rhFIX was used for comparison...
May 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/26599794/optimizing-thrombin-generation-with-4-factor-prothrombin-complex-concentrates-in-neonatal-plasma-after-cardiopulmonary-bypass
#14
Sarah W Franklin, Fania Szlam, Janet D Fernandez, Traci Leong, Kenichi A Tanaka, Nina A Guzzetta
BACKGROUND: Bleeding is a serious complication after pediatric cardiopulmonary bypass (CPB) that is associated with an increase in perioperative morbidity and mortality. Four-factor prothrombin complex concentrates (4F-PCCs) have been used off-label to supplement transfusion protocols for bleeding after CPB in adults; however, data on their use in neonates are limited. In this study, we hypothesized that 4F-PCCs administered ex vivo to neonatal plasma after CPB will increase thrombin generation...
April 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/26570865/1204-activated-pcc-feiba-for-reversal-of-rivaroxaban-induced-life-threatening-bleeding-a-case-series
#15
Elizabeth Messana, Suprat Saely Wilson
No abstract text is available yet for this article.
December 2015: Critical Care Medicine
https://www.readbyqxmd.com/read/26545367/the-role-of-feiba-in-reversing-novel-oral-anticoagulants-in-intracerebral-hemorrhage
#16
Jamil R Dibu, Jonathan M Weimer, Christine Ahrens, Edward Manno, Jennifer A Frontera
BACKGROUND: Activated prothrombin complex concentrates factor eight inhibitor bypassing activity (FEIBA) has been recommended for reversing novel oral anticoagulants (NOAC) in the context of intracerebral hemorrhage (ICH), though few clinical studies report its use. METHODS: A prospective study of patients with spontaneous ICH was conducted from May 2013 to May 2015. Hospital complications including hemorrhage (gastrointestinal bleeding, anemia requiring transfusion, and surgical site bleeding) and thrombosis (pulmonary embolus, deep vein thrombosis, ischemic stroke, and myocardial infarction) were recorded...
June 2016: Neurocritical Care
https://www.readbyqxmd.com/read/26540130/-bleedings-under-noac-non-vitamin-k-dependent-oral-anticoagulants-evidence-and-practical-management
#17
J Koscielny, E Rutkauskaite
UNLABELLED: The doses of these drugs are barely tested and the potential clinical thromboembolic risk must be taken into account. Despite the widespread use of NOAC (non vitamin-K dependent oral anticoagulants) and recommendations of regulatory agencies and first consensus meeting on handling the bleeding situation under NOAC, especially in hospitals without a large hemostatic focus, uncertainty still exists. In case of mild bleeding from a clinical perspective, the medical care of these patients and the delay of the next dose or discontinuation is advised...
2015: Hämostaseologie
https://www.readbyqxmd.com/read/26505666/activated-prothrombin-complex-concentrate-feiba%C3%A2-for-the-treatment-and-prevention-of-bleeding-in-patients-with-acquired-haemophilia-a-sequential-study
#18
Ezio Zanon, Marta Milan, Gabriella Gamba, Chiara Ambaglio, Graziella Saggiorato, Luca Spiezia, Nadia Montani, Paolo Prandoni
Despite anti-haemorrhagic therapy with proper doses of activated prothrombin complex concentrate (aPCC, Feiba®), patients with acquired haemophilia A (AHA) have a considerable risk of recurrent bleeding complications. Evidence in support of the benefit-to-risk ratio of prevention strategies with the use of lower doses of aPCC following the end of the initial treatment period is scarce and inconclusive. We report our experience in the management of 18 consecutive patients with AHA admitted to two Haemophilia centres in Italy...
December 2015: Thrombosis Research
https://www.readbyqxmd.com/read/26399175/hepatitis-e-virus-and-the-safety-of-plasma-products-investigations-into-the-reduction-capacity-of-manufacturing-processes
#19
Maria R Farcet, Cornelia Lackner, Gerhard Antoine, Philip O Rabel, Andreas Wieser, Andreas Flicker, Ulrike Unger, Jens Modrof, Thomas R Kreil
BACKGROUND: Hepatitis E virus (HEV) has been transmitted by transfusion of labile blood products and the occasional detection of HEV RNA in plasma pools indicates that HEV viremic donations might enter the manufacturing process of plasma products. To verify the safety margins of plasma products with respect to HEV, virus reduction steps commonly used in their manufacturing processes were investigated for their effectiveness to reduce HEV. STUDY DESIGN AND METHODS: Detection methods for HEV removal (by reverse transcription quantitative polymerase chain reaction) and inactivation (using an infectivity assay) were established...
February 2016: Transfusion
https://www.readbyqxmd.com/read/26346326/refractory-epistaxis-due-to-severe-factor-v-deficiency-with-inhibitor
#20
Elizabeth S John, Minesh D Patel, Julio Hajdenberg
Factor V deficiency secondary to inhibitors is extremely rare and can be caused by a wide collection of exposures such as bovine thrombin and beta lactamase antibiotics. The management of factor V deficiency with inhibitor is a condition treated based on case reports due to the rarity of this condition. We describe a complicated case of an elderly patient with severe factor V deficiency with high inhibitor titer refractory to FEIBA (anti-inhibitor coagulation complex) treated with NovoSeven concurrently with cyclosporine immunosuppression and Rituxan...
2015: Case Reports in Hematology
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