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https://www.readbyqxmd.com/read/29138541/the-effect-of-peer-support-in-adults-with-insulin-pump-treated-type-1-diabetes-a-pilot-study-of-a-flexible-and-participatory-intervention
#1
Lene Eide Joensen, Merete Meldgaard Andersen, Sabrina Jensen, Kirsten Nørgaard, Ingrid Willaing
Aim: The aim of this study was to explore the effects of a flexible and participatory peer support intervention in a clinical setting for adults with type 1 diabetes treated with an insulin pump, focusing on enhancing diabetes-specific social capital. The key questions were as follows: 1) what effects are appropriate to expect, according to participants? and 2) to what extent did these effects occur? Methods: Two peer support intervention programs were conducted in a diabetes specialist clinic (N=30)...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29120503/route-to-improving-type-1-diabetes-mellitus-glycaemic-outcomes-real-world-evidence-taken-from-the-national-diabetes-audit
#2
A H Heald, M Livingston, A Fryer, G Y C Moreno, N Malipatil, R Gadsby, W Ollier, M Lunt, M Stedman, R J Young
AIM: To use general practice-level data for England, available through the National Diabetes Audit, and primary care prescribing data to identify prescription treatment factors associated with variations in achieved glucose control (HbA1c ). METHODS: General practice-level National Diabetes Audit data on Type 1 diabetes, including details of population characteristics, services, proportion of people achieving target glycaemic control [HbA1c ≤58 mmol/mol (7.5%)] and proportion of people at high glycaemic risk [HbA1c >86 mmol/ml (10%)], were linked to 2013-2016 primary care diabetes prescribing data on insulin types and blood glucose monitoring for all people with diabetes...
November 9, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29118059/diabetes-care-disparities-in-long-standing-type-1-diabetes-in-canada-and-the-united-states-a-cross-sectional-comparison
#3
Alanna Weisman, Leif E Lovblom, Hillary A Keenan, Liane J Tinsley, Stephanie D'Eon, Genevieve Boulet, Mohammed A Farooqi, Julie A Lovshin, Andrej Orszag, Yuliya Lytvyn, Michael H Brent, Narinder Paul, Vera Bril, David Z Cherney, Bruce A Perkins
OBJECTIVE: To assess national differences in diabetes care and quality of life (QOL) between individuals with long-standing type 1 diabetes (≥50 years) in Canada and the U.S. RESEARCH DESIGN AND METHODS: Cross-sectional data from identical surveys administered in the Canadian Study of Longevity in Diabetes and the Joslin Medalist Study, collected in 2013-2016 and 2005-2011, respectively, were compared. Laboratory values and ophthalmic examination were completed by clinical care physicians for Canadians and the Joslin Clinic for Americans...
November 8, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29117449/route-to-improving-type-1-diabetes-mellitus-glycaemic-outcomes-real-world-evidence-taken-from-the-national-diabetes-audit
#4
P J Hammond
The National Diabetes Audit (NDA) has helped to highlight the disparity in glycaemic outcomes between those with Type 1 and those with Type 2 diabetes. Whilst ~70% of those with Type 2 diabetes achieve an HbA1c concentration <58 mmol/mol (7.5%), only 30% of those with Type 1 diabetes do so. Heald et al. [1] have used the data from the NDA to determine whether improved uptake of technology, particularly insulin pump therapy, might improve glycaemic outcomes. This article is protected by copyright. All rights reserved...
November 8, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29107758/exploring-correlates-of-diabetes-related-stress-among-adults-with-type-1-diabetes-in-the-t1d-exchange-clinic-registry
#5
Matthew Tyler Boden, Sasha Gala
AIMS: To explore relations between diabetes-related stress and multiple sociodemographic, diabetes health, other health, and treatment-related variables among a large, diverse sample of adults with Type 1 Diabetes (T1D). METHODS: The sample consisted of 10,821 adults (over 18 years old) enrolled in the T1D Exchange Clinic Registry. The T1D Exchange clinic network consists of 67 diabetes clinical centers throughout the United States selected to broadly represent pediatric and adult patients with T1D...
October 28, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29099466/association-of-proton-pump-inhibitor-use-with-serum-biomarkers-of-inflammation-insulin-resistance-cardiovascular-risk-and-renal-function
#6
Gregory L Austin, Jennifer R Weiskopf, Jennifer L Czwornog
BACKGROUND AND GOALS: Proton pump inhibitor (PPI) use has been associated with cardiovascular disease, chronic kidney disease, and dementia. Prior studies did not account for key confounders and little is known about the association of PPIs with serum biomarkers of inflammation, insulin resistance, cardiovascular risk, and renal function. Our aims were to investigate differences in these biomarkers between PPI users and nonusers. METHODS: Our data are from the National Health and Nutrition Examination Survey (NHANES), a complex cross-sectional multistage probability sample of the US civilian population...
November 3, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29092790/self-rated-health-among-american-adolescents-with-type-1-diabetes-in-the-t1d-exchange-clinic-registry
#7
Nada A Abualula, Margaret F Rodan, Renee A Milligan, Kathryn H Jacobsen
BACKGROUND: The goal of this study was to examine the self-rated health (SRH) of adolescents with type 1 diabetes (T1D). METHODS: A logistic regression analysis of baseline data from adolescents in the United States included in the T1D Exchange Clinic Registry in 2010-2012 was conducted. Participants were 13-18years old at the time of enrollment in the registry and had been diagnosed with T1D at least one year before enrollment (n=5799). RESULTS: Half (49...
September 23, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29090346/activation-of-insulin-like-growth-factor-1-receptor-participates-downstream-of-gpr30-in-estradiol-17%C3%AE-d-glucuronide-induced-cholestasis-in-rats
#8
Ismael R Barosso, Gisel S Miszczuk, Nadia Ciriaci, Romina B Andermatten, Paula M Maidagan, Valeria Razori, Diego R Taborda, Marcelo G Roma, Fernando A Crocenzi, Enrique J Sánchez Pozzi
Estradiol-17β-D-glucuronide (E17G), through the activation of different signaling proteins, induces acute endocytic internalization of canalicular transporters in rat, including multidrug resistance-associated protein 2 (Abcc2) and bile salt export pump (Abcb11), generating cholestasis. Insulin-like growth factor 1 receptor (IGF-1R) is a membrane-bound tyrosine kinase receptor that can potentially interact with proteins activated by E17G. The aim of this study was to analyze the potential role of IGF-1R in the effects of E17G in isolated perfused rat liver (IPRL) and isolated rat hepatocyte couplets...
October 31, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29080975/loss-of-renal-snx5-results-in-impaired-ide-activity-and-insulin-resistance-in-mice
#9
Fengmin Li, Jian Yang, Van Anthony M Villar, Laureano D Asico, Xiaobo Ma, Ines Armando, Hironobu Sanada, Minoru Yoneda, Robin A Felder, Pedro A Jose, Xiaoyan Wang
AIMS/HYPOTHESIS: We hypothesised that renal sorting nexin 5 (SNX5) regulates the insulin-degrading enzyme (IDE) and, thus, circulating insulin levels. We therefore studied the dynamic interaction between SNX5 and IDE in human renal proximal tubule cells (hRPTCs), as well as in rat and mouse kidneys. METHODS: The regulation of IDE by SNX5 expressed in the kidney was studied in vitro and in vivo. Snx5 or mock siRNA was added to immortalised hRPTCs (passage <20) in culture or selectively infused, via osmotic mini-pump, into the remnant kidney of uninephrectomised mice and rats...
October 28, 2017: Diabetologia
https://www.readbyqxmd.com/read/29080577/a-primer-on-insulin-pump-therapy-for-health-care-providers
#10
REVIEW
Deborah L McCrea
An estimated 1 million people use an insulin pump to manage their diabetes. Few medical professionals understand or feel comfortable caring for people who use an insulin pump. This article will help the medical professional understand the reasons why the insulin pump helps the user to achieve better glycemic control, have more flexibility, and enjoy a better quality of life. Additionally, this article discusses the advantages, disadvantages, candidate selection, contraindications, basic functions, and troubleshooting of the insulin pump...
December 2017: Nursing Clinics of North America
https://www.readbyqxmd.com/read/29075006/a-new-method-for-targeted-and-sustained-induction-of-type-2-diabetes-in-rodents
#11
Dino Premilovac, Robert J Gasperini, Sarah Sawyer, Adrian West, Michelle A Keske, Bruce V Taylor, Lisa Foa
Type 2 diabetes is a chronic metabolic disorder that is becoming a leading cause of morbidity and mortality. The prolonged time-course of human type 2 diabetes makes modelling of the disease difficult and additional animal models and methodologies are needed. The goal of this study was to develop and characterise a new method that allows controlled, targeted and sustained induction of discrete stages of type 2 diabetes in rodents. Using adult, male rats, we employed a three-week high fat-diet regimen and confirmed development of obesity-associated glucose intolerance, a key feature of human type 2 diabetes...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29073304/environmental-factors-affecting-management-of-type-1-diabetes-in-children-below-the-age-of-10
#12
Katarzyna Piechowiak, Beata Zduńczyk, Agnieszka Szypowska
INTRODUCTION: The way parents manage diabetes of their small children and environmental influence are crucial for maintaining glycemic control. The aim of the study was to assess environmental factors affecting metabolic control of young children with T1D treated with insulin pumps. MATERIAL AND METHODS: Parents of children with T1D under the age of 10 years completed: General Self-Efficacy Scale, Parental Diabetes Quality of Life Questionnaire, Beck Depression Inventory and a questionnaire on socioeconomic factors...
2017: Pediatric Endocrinology, Diabetes, and Metabolism
https://www.readbyqxmd.com/read/29068709/altered-patterns-of-early-metabolic-decompensation-in-type-1-diabetes-during-treatment-with-a-sglt2-inhibitor-an-insulin-pump-suspension-study
#13
Neha S Patel, Michelle A Van Name, Eda Cengiz, Lori R Carria, Stuart A Weinzimer, William V Tamborlane, Jennifer L Sherr
BACKGROUND: Enthusiasm for the benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2i) as an adjunctive treatment in type 1 diabetes (T1D) has been offset by the possible increased risk of diabetic ketoacidosis (DKA). Since pump-treated T1D patients are susceptible to DKA due to infusion site problems, this study was undertaken to assess how treatment with SGLT2i affects patterns of early metabolic decompensation following suspension of basal insulin. METHODS: Ten T1D participants (age 19-35 years, duration 10 ± 8 years, A1c 7...
November 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29066463/angiotensin-1-7-stimulates-brown-adipose-tissue-and-reduces-diet-induced-obesity
#14
Hidechika Morimoto, Jun Mori, Hisakazu Nakajima, Yasuhiro Kawabe, Yusuke Tsuma, Shota Fukuhara, Kazuki Kodo, Kazuya Ikoma, Satoaki Matoba, Gavin Y Oudit, Hajime Hosoi
The renin-angiotensin system is a key regulator of metabolism with beneficial effects of the angiotensin 1-7 peptide. We hypothesized that the anti-obesity effect of Ang 1-7 is related to the stimulation of brown adipose tissue (BAT). We administered Ang 1-7 (0.54 mg・kg(-1)・d(-1)) for 28 days via implanted micro-osmotic pumps to mice with high-fat diet (HFD) induced obesity. Ang 1-7 treatment reduced body weight, upregulated thermogenesis and ameliorated impaired glucose homeostasis without affecting food consumption...
October 24, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29060152/personalization-of-a-compartmental-physiological-model-for-an-artificial-pancreas-through-integration-of-patient-s-state-estimation
#15
P Jallon, S Lachal, C Franco, G Charpentier, E Huneker, M Doron, Sylvia Franc, Pierre-Yves Benhamou, Sophie Borot, Bruno Guerci, He le Ne Hanaire, Nathalie Jeandidier, Alfred Penfornis, Eric Renard, Yves Reznik, Pauline Schaepelynck, Chantal Simon
Artificial Pancreas (AP) are developed for patients with Type 1 diabetes. This medical device system consists in the association of a subcutaneous continuous glucose monitor (CGM) providing a proxy of the patient's glycaemia and a control algorithm offering the real-time modification of the insulin delivery with an automatic command of the subcutaneous insulin pump. The most complex algorithms are based on a compartmental model of the glucoregulatory system of the patient coupled to an approach of MPC (Model-Predictive-Control) for the command...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29055098/the-safety-of-the-batteries-and-power-units-used-in-insulin-pumps-a-pilot-cross-sectional-study-by-the-association-for-the-study-of-innovative-diabetes-treatment-in-japan
#16
Takashi Murata, Shinsuke Nirengi, Naoki Sakane, Akio Kuroda, Yushi Hirota, Munehide Matsuhisa, Mitsuyoshi Namba, Tetsuro Kobayashi
AIMS / INTRODUCTION: We investigated the safety of the batteries and power units used in insulin pumps in Japan. MATERIALS AND METHODS: A self-administered questionnaire was sent to the 201 members of the Association for Innovative Diabetes Treatment in Japan (ASINDTJ). RESULTS: Fifty-six members responded, and among the 1,499 active devices, 66 had episodes of trouble related to the batteries and power units. The ratio of reported troubles to the number of insulin pumps was significantly higher in insulin pumps with CGM sensor compared to insulin pumps without CGM sensor (Odds ratio 2...
October 21, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29054932/improving-paediatric-residents-knowledge-and-perspectives-regarding-the-insulin-pump-using-a-novel-educational-workshop
#17
Shipra Bansal, Albara Marwa, Kannan Kasturi, Sheila Perez-Colon
OBJECTIVES: As a pilot study, we aimed to investigate the knowledge and perceptions of categorical paediatric residents (RES) at our institution regarding insulin pumps (IPs) and the impact following a targeted workshop. METHODS: All RES at our institution in attendance at a routine noon conference participated in a workshop, completing an anonymous survey before and right after the intervention to evaluate knowledge, attitudes and self-reported comfort regarding IPs...
October 20, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29049584/association-of-insulin-pump-therapy-vs-insulin-injection-therapy-with-severe-hypoglycemia-ketoacidosis-and-glycemic-control-among-children-adolescents-and-young-adults-with-type-1-diabetes
#18
COMPARATIVE STUDY
Beate Karges, Anke Schwandt, Bettina Heidtmann, Olga Kordonouri, Elisabeth Binder, Ulrike Schierloh, Claudia Boettcher, Thomas Kapellen, Joachim Rosenbauer, Reinhard W Holl
Importance: Insulin pump therapy may improve metabolic control in young patients with type 1 diabetes, but the association with short-term diabetes complications is unclear. Objective: To determine whether rates of severe hypoglycemia and diabetic ketoacidosis are lower with insulin pump therapy compared with insulin injection therapy in children, adolescents, and young adults with type 1 diabetes. Design, Setting, and Participants: Population-based cohort study conducted between January 2011 and December 2015 in 446 diabetes centers participating in the Diabetes Prospective Follow-up Initiative in Germany, Austria, and Luxembourg...
October 10, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29030383/12-week-24-7-ambulatory-artificial-pancreas-with-weekly-adaptation-of-insulin-delivery-settings-effect-on-hemoglobin-a1c-and-hypoglycemia
#19
Eyal Dassau, Jordan E Pinsker, Yogish C Kudva, Sue A Brown, Ravi Gondhalekar, Chiara Dalla Man, Steve Patek, Michele Schiavon, Vikash Dadlani, Isuru Dasanayake, Mei Mei Church, Rickey E Carter, Wendy C Bevier, Lauren M Huyett, Jonathan Hughes, Stacey Anderson, Dayu Lv, Elaine Schertz, Emma Emory, Shelly K McCrady-Spitzer, Tyler Jean, Paige K Bradley, Ling Hinshaw, Alejandro J Laguna Sanz, Ananda Basu, Boris Kovatchev, Claudio Cobelli, Francis J Doyle
OBJECTIVE: Artificial pancreas (AP) systems are best positioned for optimal treatment of type 1 diabetes (T1D) and are currently being tested in outpatient clinical trials. Our consortium developed and tested a novel adaptive AP in an outpatient, single-arm, uncontrolled multicenter clinical trial lasting 12 weeks. RESEARCH DESIGN AND METHODS: Thirty adults with T1D completed a continuous glucose monitor (CGM)-augmented 1-week sensor-augmented pump (SAP) period...
October 13, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29026740/diabetes-and-ramadan-a-concise-and-practical-update
#20
REVIEW
Mohamed H Ahmed, Nazik Elmalaika Husain, Wadie M Elmadhoun, Sufian K Noor, Abbas A Khalil, Ahmed O Almobarak
Despite the fact that the month of Ramadan includes 29-30 days and the duration of fasting for each day can last for between 12 and 16 h, it was estimated that a large number of individuals with diabetes do fast during Ramadan. In light of recent advancement of new pharmacological agents, drugs such as vildagliptin, sitagliptin, and liraglutide were found to be safe to use during this month of fasting. These therapeutic agents can also be used in combination with metformin. The use of sulfonylureas, in most of the recent guidelines about diabetes and Ramadan, seems not to gain much support due to the risk of hypoglycemia...
January 2017: Journal of Family Medicine and Primary Care
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