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https://www.readbyqxmd.com/read/28447026/genome-dynamics-of-escherichia-coli-during-antibiotic-treatment-transfer-loss-and-persistence-of-genetic-elements-in-situ-of-the-infant-gut
#1
Andreas Porse, Heidi Gumpert, Jessica Z Kubicek-Sutherland, Nahid Karami, Ingegerd Adlerberth, Agnes E Wold, Dan I Andersson, Morten O A Sommer
Elucidating the adaptive strategies and plasticity of bacterial genomes in situ is crucial for understanding the epidemiology and evolution of pathogens threatening human health. While much is known about the evolution of Escherichia coli in controlled laboratory environments, less effort has been made to elucidate the genome dynamics of E. coli in its native settings. Here, we follow the genome dynamics of co-existing E. coli lineages in situ of the infant gut during the first year of life. One E. coli lineage causes a urinary tract infection (UTI) and experiences several alterations of its genomic content during subsequent antibiotic treatment...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28446177/the-susceptibility-to-fosfomycin-of-gram-negative-bacteria-isolates-from-urinary-tract-infection-in-the-czech-republic-data-from-a-unicentric-study
#2
Miroslav Fajfr, Miroslav Louda, Pavla Paterová, Lenka Ryšková, Jaroslav Pacovský, Josef Košina, Helena Žemličková, Miloš Broďák
BACKGROUND: Against a background of rapid increase of β-lactamase-producing or multi-resistant pathogenic bacteria and the resulting lack of effective antibiotic treatment, some older antibiotics have been tested for new therapeutic uses. One of these is fosfomycin, to which according to studies these resistant bacteria are very sensitive. Our study was designed because there is no data on the fosfomycin susceptibility rate in the Czech Republic. METHOD: In this study from January 2013 to June 2014 3295 unique isolates of Gram-negative bacteria which had caused urinary tract infections were examined...
April 26, 2017: BMC Urology
https://www.readbyqxmd.com/read/28443576/changes-in-bacterial-resistance-patterns-of-pediatric-urinary-tract-infections-in-%C3%A4-stanbul-and-rationale-for-empirical-antibiotic-therapy
#3
İbrahim Gökçe, Neslihan Çiçek, Serçin Güven, Ülger Altuntaş, Neşe Bıyıklı, Nurdan Yıldız, Harika Alpay
BACKGROUND: The causative agent spectrum and resistance patterns of urinary tract infection (UTI) in children are affected by many factors. AIMS: The aim of this study was to demonstrate the antibiotic resistance in UTI and changing ratio in antibiotic resistance by years. STUDY DESIGN: Retrospective cross-sectional study. METHODS: We analyzed antibiotic resistance patterns of isolated gram (-) bacteria during years 2011-2014 (study period 2) in children with UTI...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28440605/-carbapenem-resistance-in-pseudomonas-aeruginosa-isolated-from-urine-cultures-prevalence-and-risk-factors
#4
J Álvarez-Otero, J L Lamas-Ferreiro, L González-González, I Rodríguez-Conde, M J Fernández-Soneira, A Arca-Blanco, J R Bermúdez-Sanjurjo, J de la Fuente-Aguado
OBJECTIVE: Pseudomonas aeruginosa is a non-fermentative gram-negative bacillus with a great ability to develop resistance to multiple antibiotics, including carbapenems, which is a growing problem worldwide. The aim of this study was to analyse the prevalence of carbapenem-resistant P. aeruginosa (CRPA) in urine cultures and to determine the risk factors associated with the development of carbapanem resistance. METHODS: Positive urine cultures to P. aeruginosa between September 2012 and September 2014 were identified...
April 25, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28439299/substance-p-enhances-lactic-acid-and-tyramine-production-in-enterococcus-faecalis-v583-and-promotes-its-cytotoxic-effect-on-intestinal-caco-2-tc7-cells
#5
Kelly Biaggini, Valérie Borrel, Sabine Szunerits, Rabah Boukherroub, Awa N'Diaye, Arthur Zébré, Maryse Bonnin-Jusserand, Guillaume Duflos, Marc Feuilloley, Djamel Drider, Pierre Déchelotte, Nathalie Connil
BACKGROUND: Enterococcus faecalis, generally considered as a saprophytic bowel commensal, has recently emerged as an important nosocomial pathogen causing severe urinary tract infections, surgical wound infections, bacteremia, and bacterial endocarditis. This bacterium is capable of forming biofilms on various surfaces and its high level of antibiotic resistance contributes to its pathogenicity. The aim of this study was to evaluate the effect on E. faecalis, of Substance P (SP), an antimicrobial peptide that is produced in the gut and skin...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28438192/chryseobacterium-gleum-in-a-man-with-prostatectomy-in-senegal-a-case-report-and-review-of-the-literature
#6
O Arouna, F Deluca, M Camara, B Fall, B Fall, A Ba Diallo, J D Docquier, S Mboup
BACKGROUND: Here we report a rare case of a urinary tract infection due to Chryseobacterium gleum. This widely distributed Gram-negative bacillus is an uncommon human pathogen and is typically associated with health care settings. CASE PRESENTATION: We describe a case of urinary tract infection caused by Chryseobacterium gleum in a 68-year-old man of Wolof ethnicity (an ethnic group in Senegal, West Africa) who presented to our Department of Urology in a university teaching hospital (Hôpital Aristide Le Dantec) in Dakar, Senegal, 1 month after prostatectomy...
April 24, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28435789/aerococcus-urinae-an-emerging-cause-of-urinary-tract-infection-in-older-adults-with-multimorbidity-and-urologic-cancer
#7
Andrew Higgins, Tullika Garg
Aerococcus urinae is a rare organism isolated from urine cultures. We present a case of an 80 year-old male with bladder cancer and multimorbidity who developed A. urinae infection. A. urinae may cause simple and complicated UTIs, bacteremia, and endocarditis in older adults with multimorbidity, chronic urinary retention, or indwelling catheters. A. urinae treatment should employ penicillin, amoxicillin, and nitrofurantoin. Due to increasing antibiotic resistance, urine culture should include antibiotic susceptibility testing...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28432607/impact-of-the-medical-specialty-on-knowledge-regarding-multidrug-resistant-organisms-and-strategies-toward-antimicrobial-stewardship
#8
Steffen Lebentrau, Christian Gilfrich, Malte W Vetterlein, Harald Schumacher, Philipp J Spachmann, Sabine D Brookman-May, Hans M Fritsche, Martin Schostak, Florian M Wagenlehner, Maximilian Burger, Matthias May
PURPOSE: Evidence is scarce on subject-specific knowledge of multidrug-resistant organisms and rational use of antibiotics. We aimed at evaluating attitude, perception, and knowledge about multidrug-resistant organisms (MDRO) and antibiotic prescribing among urologists versus other medical specialties. METHODS: Within the MR2-study (Multiinstitutional Reconnaissance of practice with MultiResistant bacteria), a questionnaire was conducted targeting general surgeons, internists, gynecologists, and urologists in 18 German hospitals...
April 21, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28431777/lomefloxacin
#9
Reem I Al-Wabli
Lomefloxacin is a second-generation difluorinated broad-spectrum quinolone antibiotic. It is used for the treatment of bronchitis, urinary tract infection, conjunctivitis, otitis externa, and otitis media. A comprehensive profile was performed on lomefloxacin including nomenclature, formulae, elemental composition appearance, and physical characteristics. Spectral methods including ultraviolet spectrum, vibrational spectrum, (1)H and (13)C nuclear magnetic resonance one- and two-dimensional spectra, and mass spectrum were used for both identification and analysis of the drug...
2017: Profiles of Drug Substances, Excipients, and related Methodology
https://www.readbyqxmd.com/read/28428302/draft-genome-sequence-of-a-multidrug-resistant-pseudomonas-aeruginosa-strain-isolated-from-a-patient-with-a-urinary-tract-infection-in-khartoum-sudan
#10
Mohamed Hussain, Malik Suliman, Abdalla Ahmed, Hisham Altayb, Elamin Elneima
Pseudomonas aeruginosa infection is difficult to treat due to the presence of antibiotic resistance determinants. Here, we report the genome sequence of a multidrug-resistant P. aeruginosa strain isolated from a patient with a urinary tract infection in 2015.
April 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28424831/-recurrent-and-catheter-associated-urinary-tract-infections-prophylaxis-and-prevention
#11
H Piechota
Urinay tract infection (UTI) as one of the most frequent bacterial infections in humans is of utmost relevance. Because of the rising prevalence of antimicrobial resistance, urinalysis should always include urine culture and a resistogram in order to avoid an unspecific selection and overuse of antibiotics. Prevention of recurrent UTI must first of all rule out predisposing uropathogenic conditions. Nowadays, a great variety of drugs, behavioral, and supportive treatment options can effectively minimize UTI recurrence...
April 19, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28422664/diaper-embedded-urinary-tract-infection-monitoring-sensor-module-powered-by-urine-activated-batteries
#12
Weeseong Seo, Wuyang Yu, Tianlin Tan, Babak Ziaie, Byunghoo Jung
Urinary tract infection (UTI) is one of the most common infections in humans. UTI is easily treatable using antibiotics if identified in early stage. However, without early identification and treatment, UTI can be a major source of serious complications in geriatric patients, in particular, those suffering from neurodegenerative diseases. Also, for infants who have difficulty in describing their symptoms, UTI may lead to serious development of the disease making early identification of UTI crucial. In this paper, we present a diaper-embedded, wireless, self-powered, and autonomous UTI monitoring sensor module that allows an early detection of UTI with minimal effort...
April 14, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28420242/high-prevalence-of-ndm-metallo-%C3%AE-lactamase-among-esbl-producing-escherichia-coli-%C3%A4-solates
#13
Yeliz Çetinkol, Cemal Sandalli, Mustafa Kerem Çalgin, Arzu Altunçekiç Yildirim, Esma Akyildiz, Esin Karaman, Ayşegül Çopur Çiçek
Resistance to β-lactams in Enterobacteriaceae has been increasing worldwide. This study aimed to determine the frequency of β-lactamase genes and antibiotic resistance rates of 140 extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolates obtained from urinary tract infection in Ordu Province, Turkey. Isolates were identified by classic methods and by automated system. ESBL production was confirmed by double disk synergy test and antimicrobial susceptibility was investigated by disk diffusion method...
April 19, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28419868/ciprofloxacin-resistance-in-uropathogenic-escherichia-coli-isolates-causing-community-acquired-urinary-infections-in-bras%C3%A3-lia-brazil
#14
Rafaella Christina Rocha Moreira da Silva, Paulo de Oliveira Martins Júnior, Laura Fernandes Gonçalves, Vicente de Paulo Martins, Ana Beatriz Fabrício de Melo, André Pitondo-Silva, Tatiana Amabile de Campos
OBJECTIVES: Considering the global concern of ciprofloxacin resistance, the aim of this study was to evaluate the characteristics of ciprofloxacin-resistant (CIP-R) Escherichia coli isolated from patients with community-acquired urinary tract infections (UTIs) in Brasília, Brazil. METHODS: CIP-R E. coli isolated from different outpatients between July 2013 and April 2014 in a tertiary hospital were analysed for antibiotic resistance profile, phylotype, uropathogenic E...
April 15, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28415969/carbapenem-resistance-inappropriate-empiric-treatment-and-outcomes-among-patients-hospitalized-with-enterobacteriaceae-urinary-tract-infection-pneumonia-and-sepsis
#15
Marya D Zilberberg, Brian H Nathanson, Kate Sulham, Weihong Fan, Andrew F Shorr
BACKGROUND: Drug resistance among gram-negative pathogens is a risk factor for inappropriate empiric treatment (IET), which in turn increases the risk for mortality. We explored the impact of carbapenem-resistant Enterobacteriaceae (CRE) on the risk of IET and of IET on outcomes in patients with Enterobacteriaceae infections. METHODS: We conducted a retrospective cohort study in Premier Perspective database (2009-2013) of 175 US hospitals. We included all adult patients with community-onset culture-positive urinary tract infection (UTI), pneumonia, or sepsis as a principal diagnosis, or as a secondary diagnosis in the setting of respiratory failure, treated with antibiotics within 2 days of admission...
April 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28414519/effect-of-a-food-supplement-containing-l-methionine-on-urinary-tract-infections-in-pregnancy-a-prospective-multicenter-observational-study
#16
Mario Passaro, Giampaolo Mainini, Francesco Ambrosio, Raimondo Sgambato, Giancarlo Balbi
OBJECTIVE: Adjuvants or alternatives to antibiotics in urinary tract infections (UTIs) during pregnancy seem advisable because of possible fetal stress. The present study assessed the effectiveness of a food supplement containing L-methionine and Hibiscus sabdariffa L. and Boswellia serrata Roxb. extracts as a treatment for symptomatic UTIs in pregnancy. DESIGN: Pregnant patients with symptomatic cystitis were screened for UTIs in three different clinical centers...
April 17, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28412932/isolation-of-enterococci-their-antimicrobial-susceptibility-patterns-and-associated-factors-among-patients-attending-at-the-university-of-gondar-teaching-hospital
#17
Amelework Yilema, Feleke Moges, Sisay Tadele, Mengistu Endris, Afework Kassu, Wondwossen Abebe, Getnet Ayalew
BACKGROUND: Enterococci become clinically important especially in immune compromised patients and important causes of nosocomial infections. Data on the prevalence, antimicrobial susceptibility patterns and associated factors of enterococci are scarce in Ethiopia. METHODS: A hospital based cross-sectional study was conducted at the University of Gondar Teaching Hospital from February 28, 2014 to May 1, 2014. Pretested structured questionnaire was used to collect socio-demographic data and possible associated factors of enterococci infections...
April 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28410918/comparison-of-urinary-tract-infection-antibiograms-stratified-by-emergency-department-patient-disposition
#18
Lee Grodin, Alyssa Conigliaro, Song-Yi Lee, Michael Rose, Richard Sinert
OBJECTIVE: Institutional antibiograms guide Emergency Department (ED) clinicians' empiric antibiotic selection. For this study, we created and compared antibiograms of ED patients stratified by disposition (admitted or discharged). METHODS: We conducted a cross-sectional study at two hospitals for 2014, comparing antibiograms limited to Escherichia coli urinary tract infections. Study-Specific Antibiograms, created for the study, excluded polymicrobial samples and multiple cultures from the same patient...
March 23, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28410366/brief-educational-interventions-to-improve-performance-on-novel-quality-metrics-in-ambulatory-settings-in-kenya-a-multi-site-pre-post-effectiveness-trial
#19
Robert Ryan Korom, Stephanie Onguka, Peter Halestrap, Maureen McAlhaney, Mary Adam
BACKGROUND: The quality of primary care delivered in resource-limited settings is low. While some progress has been made using educational interventions, it is not yet clear how to sustainably improve care for common acute illnesses in the outpatient setting. Management of urinary tract infection is particularly important in resource-limited settings, where it is commonly diagnosed and associated with high levels of antimicrobial resistance. We describe an educational programme targeting non-physician health care providers and its effects on various clinical quality metrics for urinary tract infection...
2017: PloS One
https://www.readbyqxmd.com/read/28407997/the-diagnosis-of-urinary-tract-infection-in-young-children-duty-study-clinical-rule-economic-evaluation
#20
MULTICENTER STUDY
William Hollingworth, John Busby, Christopher C Butler, Kathryn O'Brien, Jonathan A C Sterne, Kerenza Hood, Paul Little, Michael Lawton, Kate Birnie, Emma Thomas-Jones, Kim Harman, Alastair D Hay
OBJECTIVE: To estimate the cost-effectiveness of a two-step clinical rule using symptoms, signs and dipstick testing to guide the diagnosis and antibiotic treatment of urinary tract infection (UTI) in acutely unwell young children presenting to primary care. METHODS: Decision analytic model synthesising data from a multicentre, prospective cohort study (DUTY) and the wider literature to estimate the short-term and lifetime costs and healthcare outcomes (symptomatic days, recurrent UTI, quality adjusted life years) of eight diagnostic strategies...
April 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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