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https://www.readbyqxmd.com/read/29935339/characterization-of-killed-but-metabolically-active-uropathogenic-escherichia-coli-strain-as-possible-vaccine-candidate-for-urinary-tract-infection
#1
Zahra Jalili, Moein Saleh, Saeid Bouzari, Mohammad Pooya
BACKGROUND AND AIM: Urinary tract infection (UTI) is the second most frequent infection in human, and uropathogenic Escherichia coli is its most common cause. Although antibiotics are the standard treatment for UTI, they can cause harmful effects on gut microbiome and increase the rate of existing drug-resistant bacteria, which make the vaccine research reasonable. This study was conducted to construct a Killed but Metabolically Active (KBMA) E. coli strain, and to determine its characteristics as a possible vaccine candidate for UTI, which will be evaluated in further investigations...
June 20, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29932037/what-about-urinary-tract-infections-and-its-antibiotic-resistance-bacteria-in-ilam-iran
#2
Reza Mohebi, Khadijeh Esmaili, Nourkhoda Sadeghifard, Iraj Pakzad, Sobhan Ghafourian
Because of unknown situation of antibiotic resistance pattern in main hospital in Ilam, Iran, in an attempt we aimed to evaluate the antibiotic resistance pattern of uropathogenic bacteria obtained from referred patients to Imam Khomaini Hospital, Ilam, Iran. For this reason, 114 bacteria were collected during 9 month period and evaluated for their antibiotic resistance pattern. Our results demonstrated that E. coli as the dominant responsible for urinary tract infection. Our results demonstrated that 61.4 % (n = 70) of isolates were positive for E...
June 22, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/29928619/systematic-review-and-practice-policy-statements-on-urinary-tract-infection-prevention-in-adults-with-spina-bifida
#3
REVIEW
Michael Tradewell, Joseph J Pariser, Tony Nimeh, Sean P Elliott
Urinary tract infection (UTI) is a source of morbidity and healthcare costs in adults with spina bifida (ASB). UTI prevention strategies are often recommended, but the evidence of various approaches remains unclear. We performed a systematic review to inform a best practice policy statement for UTI prevention in ASB. On behalf of the Neurogenic Bladder Research Group (NBRG.org), we developed an a priori protocol and searched the published English literature for 30 outcomes questions addressing UTI prevention in ASB...
May 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29928502/high-molecular-weight-hyaluronic-acid-a-two-pronged-protectant-against-infection-of-the-urogenital-tract
#4
Catherine A Mowbray, Syema Shams, Git Chung, Anna Stanton, Phillip Aldridge, Andrejus Suchenko, Robert S Pickard, Ased Sm Ali, Judith Hall
Objectives: Recurrent urinary tract infections are associated with uropathogenic Escherichia coli (UPEC) ascending and infecting the urinary tract. Antibiotics provide only symptomatic relief, not prevent recurrence. Clinical evidence suggests that intravesical glycosaminoglycan therapy, such as hyaluronic acid (HA), helps reduce UTI recurrence. This has been investigated here using in vitro systems modelling the urogenital tract tissues. Methods: RT4 bladder cells were preconditioned with high molecular weight HA (> 1500 kDa) at 2 mg mL-1 and challenged with UPEC to analyse barrier protection and bacterial adherence...
2018: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29928271/mechanism-of-anti-bacterial-activity-of-zinc-oxide-nanoparticle-against-carbapenem-resistant-acinetobacter-baumannii
#5
Vishvanath Tiwari, Neha Mishra, Keval Gadani, P S Solanki, N A Shah, Monalisa Tiwari
Acinetobacter baumannii is a multi-drug resistant opportunistic pathogen, which causes respiratory and urinary tract infections. Its prevalence increases gradually in the clinical setup. Carbapenems (beta-lactam) are most effective antibiotics till now against A. baumannii , but the development of resistance against it may lead to high mortality. Therefore, it is of utmost importance to develop an alternative drug against A. baumannii . In the present study, we have synthesized ZnO nanoparticle (ZnO-NP) and characterized by X-ray diffraction, Fourier transform infrared (FTIR) spectroscopy and UV-Visible spectroscopy...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29927958/antimicrobial-susceptibility-of-gram-negative-bacilli-isolated-from-intra-abdominal-and-urinary-tract-infections-in-mexico-from-2009-to-2015-results-from-the-study-for-monitoring-antimicrobial-resistance-trends-smart
#6
Alfredo Ponce-de-Leon, Eduardo Rodríguez-Noriega, Rayo Morfín-Otero, Dora P Cornejo-Juárez, Juan C Tinoco, Areli Martínez-Gamboa, Carmen J Gaona-Tapia, M Lourdes Guerrero-Almeida, Alexandra Martin-Onraët, José Luis Vallejo Cervantes, José Sifuentes-Osornio
Antimicrobial resistance is an increasing worldwide concern, which poses unique challenges for the effective prevention and treatment of several infections, especially the ones triggered by organisms producing extended-spectrum β-lactamases (ESBL). Here, we present the surveillance results of the Study for Monitoring Antimicrobial Resistance Trends (SMART) of Gram-negative bacilli isolated from intra-abdominal infections (IAI, n = 1,235) and urinary-tract infections (UTI, n = 2,682), collected in Mexico from 2009 to 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29922534/non-surgical-pneumoperitoneum-in-the-setting-of-gram-negative-sepsis
#7
Jacob A Sambursky, Sundeep Kumar, Molly Orban, Esteban Janolo, Vladimir Neychev
Pneumoperitoneum is described as the presence of free air in the peritoneal cavity. In the majority of cases, it is the manifestation of abdominal viscus perforation, requiring an emergent surgical exploration. In rare cases, however, no evidence of perforation of the gastrointestinal or genitourinary tracts can be found at exploration, and in such cases, the pneumoperitoneum is referred to as non-surgical pneumoperitoneum. We present a case of an 87-year-old man who developed a non-surgical pneumoperitoneum in the setting of gram-negative sepsis...
April 17, 2018: Curēus
https://www.readbyqxmd.com/read/29915656/a-deadly-prescription-combination-of-methotrexate-and-trimethoprim-sulfamethoxazole
#8
Mohsin Hamid, Bilal Lashari, Irfan Ahsan, Ida Micaily, Usman Sarwar, Joseph Crocetti
Methotrexate (MTX) is a chemotherapeutic synthetic(s) phase cell cycle inhibitor, and its role has evolved as an immunological agent in autoimmune diseases like rheumatoid arthritis, psoriasis, and systemic lupus erythematosus, etc. Trimethoprim-sulfamethoxazole (TS) is one of the most widely prescribed antibiotics commonly used for urinary tract infections, exacerbations of chronic bronchitis, traveler's diarrhea, and pneumocystis pneumonia. Both MTX and TS can have significantly overlapping side effects involving dermatologic, renal, and hematological systems, and the combination of these can be deadly...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29912024/reducing-inappropriate-antibiotics-for-urinary-tract-infections-in-long-term-care-a-replication-study
#9
Denise Cooper, Marilyn McFarland, Francesca Petrilli, Cherrell Shells
BACKGROUND: Nursing home providers face challenges in urinary tract infection assessment and treatment, often prescribing unnecessary antibiotics for asymptomatic bacteriuria, a practice that can result in adverse drug reactions, drug resistance, and an increase in antibiotic-associated diarrhea. PURPOSE: The purpose of this project was to replicate the Cooper Urinary Tract Infection Program in another facility and measure its effectiveness. METHODS: Using a pre-post design, this project was implemented at a 120-bed, long-term care and rehabilitation facility located in the Midwest United States...
June 14, 2018: Journal of Nursing Care Quality
https://www.readbyqxmd.com/read/29910137/the-development-of-a-decision-tool-for-the-empiric-treatment-of-suspected-urinary-tract-infection-in-frail-older-adults-a-delphi-consensus-procedure
#10
Laura W van Buul, Hilde L Vreeken, Suzanne F Bradley, Christopher J Crnich, Paul J Drinka, Suzanne E Geerlings, Robin L P Jump, Lona Mody, Joseph J Mylotte, Mark Loeb, David A Nace, Lindsay E Nicolle, Philip D Sloane, Rhonda L Stuart, Pär-Daniel Sundvall, Peter Ulleryd, Ruth B Veenhuizen, Cees M P M Hertogh
OBJECTIVES: Nonspecific signs and symptoms combined with positive urinalysis results frequently trigger antibiotic therapy in frail older adults. However, there is limited evidence about which signs and symptoms indicate urinary tract infection (UTI) in this population. We aimed to find consensus among an international expert panel on which signs and symptoms, commonly attributed to UTI, should and should not lead to antibiotic prescribing in frail older adults, and to integrate these findings into a decision tool for the empiric treatment of suspected UTI in this population...
June 14, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29900824/an-implementation-of-next-generation-sequencing-for-prevention-and-diagnosis-of-urinary-tract-infection-in-urology
#11
Vladimir Mouraviev, Michael McDonald
INTRODUCTION: The changing face of current infection phenotypes from planktonic to biofilm type has been developed implicating bacterial biofilms in recurrent infection. To date, no specific medical treatment exists to specifically target biofilms in the human host. Similarly, the identification of a biofilm has relied upon the analysis of tissue samples with electron microscopy or DNA identification with polymerase chain reaction (PCR) and sequencing. Standard culture and sensitivity test is not able to detect a presence of biofilms...
June 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29899011/proteus-spp-as-putative-gastrointestinal-pathogens
#12
REVIEW
Amy L Hamilton, Michael A Kamm, Siew C Ng, Mark Morrison
Proteus species, members of the Enterobacteriaceae family, are usually considered commensals in the gut and are most commonly recognized clinically as a cause of urinary tract infections. However, the recent identification of Proteus spp. as potential pathogens in Crohn's disease recurrence after intestinal resection serves as a stimulus to examine their potential role as gut pathogens. Proteus species possess many virulence factors potentially relevant to gastrointestinal pathogenicity, including motility; adherence; the production of urease, hemolysins, and IgA proteases; and the ability to acquire antibiotic resistance...
July 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29896329/detection-of-antimicrobial-susceptibility-and-integrons-among-extended-spectrum-%C3%AE-lactamase-producing-uropathogenic-escherichia-coli-isolates-in-southwestern-iran
#13
Hadi Sedigh Ebrahim-Saraie, Niloofar Zahedian Nezhad, Hamid Heidari, Ashkan Motamedifar, Mohammad Motamedifar
Objectives: Urinary tract infections (UTIs) are one of the most prevalent infectious diseases and can lead to a high rate of morbidity and mortality. The emergence of multiple-drug resistant strains, particularly extended-spectrum beta-lactamases (ESBLs) producing strains, has become a global healthcare concern. Our study sought to investigate the antimicrobial resistance pattern and presence of integrons and fimH determinants among uropathogenic Escherichia coli (UPEC) isolates obtained from hospitalized Iranian patients...
May 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29893802/efficacy-of-ceftazidime-avibactam-salvage-therapy-in-patients-with-infections-caused-by-kpc-producing-klebsiella-pneumoniae
#14
Mario Tumbarello, Enrico Maria Trecarichi, Alberto Corona, Francesco Giuseppe De Rosa, Matteo Bassetti, Cristina Mussini, Francesco Menichetti, Claudio Viscoli, Caterina Campoli, Mario Venditti, Andrea De Gasperi, Alessandra Mularoni, Carlo Tascini, Giustino Parruti, Carlo Pallotto, Simona Sica, Ercole Concia, Rosario Cultrera, Gennaro De Pascale, Alessandro Capone, Spinello Antinori, Silvia Corcione, Elda Righi, Angela Raffaella Losito, Margherita Digaetano, Francesco Amadori, Daniele Roberto Giacobbe, Giancarlo Ceccarelli, Ernestina Mazza, Francesca Raffaelli, Teresa Spanu, Roberto Cauda, Pierluigi Viale
Background: Ceftazidime-avibactam (CAZ-AVI) has been approved in Europe for the treatment of complicated intra-abdominal and urinary-tract infections, as well as hospital-acquired pneumonia, and for Gram-negative infections with limited treatment options. CAZ-AVI displays in vitro activity against KPC-enzyme producers, but clinical-trial data on its efficacy in this setting are lacking. Methods: We retrospectively reviewed 138 cases of infections caused by Klebsiella pneumoniae carbapenemase-producing (KPC-Kp) in adults who received CAZ-AVI in compassionate-use programs in Italy...
June 9, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29892947/virulence-properties-of-uropathogenic-escherichia-coli-isolated-from-children-with-urinary-tract-infection-in-korea
#15
Dong Ho Kim, Bindu Subhadra, Hee Young Kang, Kyungho Woo, Jaeseok Kim, Yeo-Jin Son, Kyung Mok Sohn, Hwa-Jung Kim, Kyudong Han, Man Hwan Oh, Chul Hee Choi
Urinary tract infections (UTIs) are one of the most common types of bacterial infection in humans in various parts of the world and are caused mainly by uropathogenic Escherichia coli (UPEC). A total of 58 UPEC isolates from urine were characterized by serotyping and pulsed-field gel electrophoresis (PFGE). The majority of the UPEC strains belonged to serogroups O2 and O6. The UPEC strains were grouped under different pulsotypes and majority of them belonged to serogroups O2 and O6. Among the 14 virulence factors considered, 13 were present in various serogroups...
June 2018: Genes & Genomics
https://www.readbyqxmd.com/read/29891187/the-association-between-continuous-antibiotic-prophylaxis-and-uti-from-birth-until-initial-postnatal-imaging-evaluation-among-newborns-with-antenatal-hydronephrosis
#16
B K Varda, J B Finkelstein, H-H Wang, T Logvinenko, C P Nelson
INTRODUCTION: There is a lack of consensus regarding the use of continuous antibiotic prophylaxis (CAP) during the interval between birth and initial postnatal imaging in infants with a history of antenatal urinary tract dilation (AUTD). OBJECTIVE: To determine the incidence of urinary tract infection (UTI), and the association between CAP use and UTI during the interval between birth and the first postnatal renal ultrasound (RUS) in infants with AUTD. STUDY DESIGN: A single-institution, retrospective cohort study of newborns with a history of AUTD...
May 29, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29886011/policy-driven-revolution-of-prescription-record-in-outpatient-use-of-fluoroquinolones
#17
Shu-Chen Kuo, Shu-Man Shih, Tsai-Ling Yang Lauderdale, I-Shou Chang, Yee-Chun Chen, Chao A Hsiung, Shang-Chwen Chang
OBJECTIVE: A policy initiated in 2001 by Taiwan's National Health Insurance (NHI) Administration has effectively reduced outpatient antibiotic use except fluoroquinolones (FQs). The influence of differential regulation policy of narrow-spectrum versus broad-spectrum FQs on the prescriptions is unknown. METHODS: This study analyzed the claim records of oral FQs prescription at outpatient visits during 2000-2010 using the NHI Research Database and compared prescriptions for narrow-spectrum FQs, which are inactive against Streptococcus pneumoniae and lack formulary restriction, with those for broad-spectrum FQs...
May 29, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29885657/infectious-disease-burden-and-antibiotic-prescribing-in-primary-care-in-israel
#18
Marcelo Low, Ronit Almog, Ran D Balicer, Nicky Liberman, Raul Raz, Avi Peretz, Orna Nitzan
BACKGROUND: Antibiotics are frequently prescribed at many of the visits to primary care clinics, often for conditions for which they provide no benefit, including viral respiratory tract infections. OBJECTIVES: The aim was to evaluate primary care visits due to infectious diseases, and to estimate antibiotic prescribing and antibiotic dispensing by pharmacies. METHODS: Diagnosis of infectious disease, antibiotic prescribing and dispensing data at the individual patient level were extracted for 2015 from Clalit Health Services' electronic medical records and linked to determine the condition for which the antimicrobial was prescribed...
June 9, 2018: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/29885179/vancomycin-resistant-enterococci-a-brief-review
#19
Taskeen Raza, Sidra Rahmat Ullah, Khalid Mehmood, Saadia Andleeb
Enterococci are known as opportunistic pathogens and today are accepted as leading cause of nosocomial infections. Various enterococcal species have been identified, but the major two which cause human diseases are enterococcus faecalis and enterococcus faecium. Most common and important infections caused by them are bacteraemia, endocarditis, urinary tract infections, surgical wound infections, intra-abdominal and intra-pelvic infections. Over the last two decades the emergence of vancomycin-resistant enterococci is alarming because of high mortality rate...
May 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29882261/short-term-external-ureter-stenting-shows-significant-benefit-in-comparison-to-routine-double-j-stent-placement-after-ureterorenoscopic-stone-extraction-a-prospective-randomized-trial-the-fast-track-stent-study-fast
#20
Peter Bach, Alina Reicherz, Joel Teichman, Lisa Dahlkamp, Nicolas von Landenberg, Rein-Jueri Palisaar, Joachim Noldus, Christian von Bodman
OBJECTIVES: To determine whether short-term stenting using an external ureter catheter following ureterorenoscopic stone extraction provides a better outcome in comparison to double-J stent ureteral stenting. METHODS: Between August 2014 and August 2015, 141 patients initially managed with a double-J stent insertion were prospectively randomized to ureter catheter for 6 h vs double-J stent insertion for 5 days after stone extraction via ureteroscopy retrograde surgery (including flexible ureteroscopy retrograde surgery) in a single academic center...
June 7, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
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