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https://www.readbyqxmd.com/read/29652969/-molecular-characterization-and-antimicrobial-susceptibility-pattern-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-as-cause-of-community-acquired-urinary-tract-infection
#1
Mario Galindo-Méndez
Background Community acquired urinary tract infections (CaUTI) caused by strains of extended-spectrum β-lactamases (ESBL) - producing Escherichia coli, mainly by strains carrying the blaCTX-M-15 gene, is a growing phenomenon worldwide. Aim To determine the antibiotic susceptibility pattern of ESBL-producing E. coli as cause of CaUTI and to identify their molecular pattern. Methods A descriptive study was performed in the city of Oaxaca, Mexico, from where 288 strains of CaUTI-producing strains of E. coli in adults with possible UTI were isolated...
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29649830/healthcare-associated-infections-after-lower-urinary-tract-endoscopic-surgery-analysis-of-risk-factors-associated-microorganisms-and-patterns-of-antibiotic-resistance
#2
Raquel Sopeña-Sutil, José Medina-Polo, Juan Justo-Quintas, Javier Gil-Moradillo, Lucia Garcia-Gonzalez, Raúl Benítez-Sala, Manuel Alonso-Isa, Alba Lara-Isla, Angel Tejido-Sanchez
OBJECTIVES: To review the incidence of healthcare-associated infections/urinary tract infection (UTI), risk factors, microorganisms isolated and antibiotic resistances in patients who underwent lower urinary tract endoscopic surgery (LUTES) in a tertiary care hospital. METHODS: A prospective observational study was carried out including 1,498 patients who undergo LUTES. Patients with and without UTI after surgery were compared. We analysed infection incidence, risk factors, microorganisms isolated and antibiotic resistances...
April 12, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29649808/treatment-of-complicated-urinary-tract-infections-in-individuals-with-chronic-neurogenic-lower-urinary-tract-dysfunction-are-antibiotics-mandatory
#3
Jürgen Pannek, Susanne Pannek-Rademacher, Jens Wöllner
INTRODUCTION: Urinary tract infections (UTI) in patients with neurogenic lower urinary tract dysfunction (NLUTD) are defined as complicated UTI requiring antibiotic treatment. As the emergence of multiresistant strains is a serious problem, we assessed the feasibility of nonantibiotic treatment of UTI in patients with NLUTD. MATERIALS AND METHODS: In a prospective study evaluating the usefulness of UTI prophylaxis, participants could opt for either antibiotic or nonantibiotic treatment of breakthrough UTI...
April 12, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29649268/a-case-control-study-of-lower-urinary-tract-infections-associated-antibiotics-and-the-risk-of-developing-prostate-cancer-using-pcbase-3-0
#4
Beth Russell, Hans Garmo, Kerri Beckmann, Pär Stattin, Jan Adolfsson, Mieke Van Hemelrijck
OBJECTIVES: To investigate the association between lower urinary-tract infections, their associated antibiotics and the subsequent risk of developing PCa. SUBJECTS/PATIENTS (OR MATERIALS) AND METHODS: Using data from the Swedish PCBaSe 3.0, we performed a matched case-control study (8762 cases and 43806 controls). Conditional logistic regression analysis was used to assess the association between lower urinary-tract infections, related antibiotics and PCa, whilst adjusting for civil status, education, Charlson Comorbidity Index and time between lower urinary-tract infection and PCa diagnosis...
2018: PloS One
https://www.readbyqxmd.com/read/29649026/evidence-review-conducted-for-the-agency-for-healthcare-research-and-quality-safety-program-for-improving-surgical-care-and-recovery-focus-on-anesthesiology-for-colorectal-surgery
#5
Kristen A Ban, Melinda M Gibbons, Clifford Y Ko, Elizabeth C Wick, Maxime Cannesson, Michael J Scott, Michael C Grant, Christopher L Wu
The Agency for Healthcare Research and Quality, in partnership with the American College of Surgeons and the Johns Hopkins Medicine Armstrong Institute for Patient Safety and Quality, has developed the Safety Program for Improving Surgical Care and Recovery (ISCR), which is a national effort to disseminate best practices in perioperative care to more than 750 hospitals across multiple procedures in the next 5 years. The program will integrate evidence-based processes central to enhanced recovery and prevention of surgical site infection, venous thromboembolic events, catheter-associated urinary tract infections with socioadaptive interventions to improve surgical outcomes, patient experience, and perioperative safety culture...
April 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29625943/drug-utilization-and-prescribing-pattern-of-antibiotics-in-a-tertiary-care-setups-trends-and-practices
#6
Huma Ali, Farya Zafar, Shazia Alam, Anwar Ejaz Beg, Rabia Bushra, Ammara Manzoor, Ghazala R Naqvi, Riffat Yasmeen, Yousra Shafiq, Anum Tariq, Saba Zubair, Saima Saleem
Irrational, over and misuse of antibiotics arise as global concern in both hospital and community settings and lead to adverse events including antimicrobial resistance, associated health problems, amplified hospitalization stay and cost. Hence, Drug Utilization Evaluation (DUE) studies are designed to evaluate and improve the prescribing, administration and the rational use of medications. The present study was designed to assess the pattern of antimicrobial drug utilization in in-patients cohort of tertiary care setup in Karachi, Pakistan...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29622716/bilateral-multifocal-acute-lobar-nephronia-caused-by-enterococcus-faecalis
#7
Yoshiki Kusama, Kunio Muraki
An 8-year-old boy presented to our hospital with complaints of fever, epigastric pain and headache. Enterococcus faecalis were isolated from urine and blood culture, bacteraemic urinary tract infection was clinically diagnosed. Although vancomycin and ampicillin were administrated, fever did not subside. Contrast-enhanced CT (CECT) revealed bilateral and multiple wedge-shaped defects, thus prompting a diagnosis of acute lobar nephronia (ALN). After 7 days of antibiotic treatment, the patient's fever subsided...
April 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29619335/role-of-neomycin-polymyxin-sulfate-solution-bladder-wash-for-prevention-of-catheter-associated-urinary-tract-infection-in-traumatic-brain-injury-patient-admitted-to-intensive-care-unit-a-prospective-randomized-study
#8
Neeraj Kumar, Yashpal Singh, Ghanshyam Yadav, S K Mathur, Umesh Kumar Bhadani
Background: Catheter - associated urinary tract infection (CAUTI) remains a critical threat for patients in intensive care unit especially in traumatic brain injury patients with low Glasgow coma score (GCS). Almost all patients in ICU receive antibiotic either prophylactic or therapeutic based on local antibiogram of particular ICU or hospital. For prophylaxis, systemic antibiotics are used. It will be helpful to avoid systemic side effects by introducing antibiotics locally through bladder irrigation...
January 2018: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/29619292/rate-of-antibiotic-prescriptions-in-german-outpatient-care-are-the-guidelines-followed-or-are-they-still-exceeded
#9
Janine Zweigner, Elisabeth Meyer, Petra Gastmeier, Frank Schwab
Aim: The consequences of antibiotic overuse are substantial. We combined and analyzed the infection diagnoses and antibiotic prescribing practices of physicians in outpatient settings. Recommendations for targeting policy efforts to focused areas are given. Methods: Antibiotic prescriptions and infections diagnosed were provided by a German statutory health insurance provider over a 12-month period. Antibiotic use was expressed as prescriptions per 100 patients. Results: 2,594,000 patient-physician contacts within twelve months were analyzed...
2018: GMS Hygiene and Infection Control
https://www.readbyqxmd.com/read/29618675/prevalence-of-escherichia-coli-resistant-to-beta-lactam-antibiotics-among-patients-with-chronic-obstructive-pulmonary-disease-and-urinary-tract-infection
#10
Emilija Nikolić, Tijana Brandmajer, Vesna Bokan, Maria Ulyashova, Maya Rubtsova
Urinary tract infection (UTI), which is typically caused by Escherichia coli (E. coli), is an insufficiently recognized co-morbidity among patients with chronic obstructive pulmonary disease (COPD). Adequate treatment can be complicated by resistance of the causative pathogen to beta-lactam antibiotics, which often produce beta-lactamase enzymes that destroy the antibiotic. The beta-lactamase family of enzymes is extremely diverse, including different types of enzyme and mutant forms. In this study, we analyzed 580 patients with COPD (236 females and 344 males) and thus found 218 patients with co-morbid UTIs, including 58 patients with UTI caused by E...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29617742/a-statewide-antibiotic-stewardship-collaborative-to-improve-the-diagnosis-and-treatment-of-urinary-tract-and-skin-and-soft-tissue-infections
#11
Timothy C Jenkins, Teresa Hulett, Bryan C Knepper, Katherine C Shihadeh, Marc J Meyer, Gerard R Barber, John H Hammer, Heidi L Wald
Background: Colorado hospitals participated in a statewide collaborative to improve the diagnosis and treatment of inpatient urinary tract infections (UTI) and skin and soft tissue infections (SSTI). We evaluated the effects of the intervention on diagnostic accuracy and antibiotic use. Methods: The collaborative outcomes were: (1) proportion of UTI diagnoses meeting criteria for symptomatic UTI; (2) exposure to fluoroquinolones (UTI only); (3) duration of therapy (UTI and SSTI); and (4) exposure to antibiotics with broad gram-negative activity (SSTI only)...
March 30, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29617710/negative-association-of-antibiotics-on-clinical-activity-of-immune-checkpoint-inhibitors-in-patients-with-advanced-renal-cell-and-non-small-cell-lung-cancer
#12
L Derosa, M D Hellmann, M Spaziano, D Halpenny, M Fidelle, H Rizvi, N Long, A J Plodkowski, K C Arbour, J E Chaft, J A Rouche, L Zitvogel, G Zalcman, L Albiges, B Escudier, B Routy
Background: The composition of gut microbiota affects anti-tumor immune responses, preclinical and clinical outcome following immune checkpoint inhibitors (ICI) in cancer. Antibiotics (ATB) alter gut microbiota diversity and composition leading to dysbiosis, which may affect effectiveness of ICI. Patients and Methods: We examined patients with advanced renal cell carcinoma (RCC) and non-small cell lung cancer (NSCLC) treated with anti-PD-(L)1 mAb monotherapy or combination at two academic institutions...
March 30, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29617701/isolation-and-characterization-of-a-lytic-bacteriophage-vb_pmis-th-and-its-application-in-combination-with-ampicillin-against-planktonic-and-biofilm-forms-of-proteus-mirabilis-isolated-from-urinary-tract-infection
#13
Mahsa Yazdi, Majid Bouzari, Ezzat Allah Ghaemi
Proteus mirabilis is one of the most common causes of urinary tract infection (UTI), particularly in patients undergoing long-term catheterization. Phage vB_PmiS-TH was isolated from wastewater with high lytic activity against P. mirabilis (TH) isolated from UTI. The phage had rapid adsorption, a large burst size (∼260 PFU per infected cell), and high stability at a wide range of temperatures and pH values. As analyzed by transmission electron microscopy, phage vB_PmiS-TH had an icosahedral head of ∼87 × 62 nm with a noncontractile tail about 137 nm in length and 11 nm in width...
April 4, 2018: Journal of Molecular Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29603811/utility-of-catheterized-specimens-in-reducing-overdiagnosis-of-urinary-tract-infections-in-women
#14
Carrie M Aisen, Erica Ditkoff, Arindam RoyChoudhury, Michele Corish, Matthew P Rutman, Doreen E Chung, Gina M Badalato, Kimberly L Cooper
AIMS: To evaluate the utility of catheterized samples in reducing overdiagnosis of UTI based on voided specimens among patients presenting with a range of urinary symptoms. We also aimed to determine variables that may modify the predictive value of the voided midstream urine culture. METHODS: Patient charts were reviewed to identify female patients referred to our voiding dysfunction clinic with a range of complaints warranting urine studies (5/2014-8/2016). Patients with a positive voided urine culture who also had a catheterized urine culture in our system were included...
March 31, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29602464/use-of-lactobacillus-spp-to-prevent-recurrent-urinary-tract-infections-in-females
#15
Qin Xiang Ng, Christina Peters, Nandini Venkatanarayanan, Yan Yih Goh, Collin Yih Xian Ho, Wee-Song Yeo
Urinary tract infections (UTIs) are the most common bacterial infections seen in the community, especially amongst females. The widespread use of antibiotics has led to the increased occurrence of E. coli resistant isolates worldwide. A promising non-antibiotic approach is the use of probiotic lactobacilli strains. This paper hypothesizes that Lactobacillus spp. containing products are able to prevent recurrent urinary tract infections in females. Using the keywords [lactobacillus OR lactobacilli OR probiotic] and [urinary tract infection OR UTI OR cystitis], a preliminary search on the PubMed, Ovid, Google Scholar and ClinicalTrials...
May 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29596766/-bacteriuria-cochrane-database-syst-rev-2015-4-cd009534
#16
Miguel Bigotte Vieira, Mariana Alves, João Costa, António Vaz-Carneiro
Asymptomatic bacteriuria is frequently detected in women aged up to 60 years, patients with diabetes and elderly patients. The benefit of antibiotic treatment for this condition is controversial. The objective of this Cochrane systematic review was to assess the effectiveness and safety of antibiotic treatment for asymptomatic bacteriuria in adults. A systematic review of the literature up to 24 February 2015 was performed using the Cochrane Renal Group's Specialised Register. Randomised controlled trials (RCTs) and quasirandomised controlled trials comparing antibiotics to placebo or no treatment for asymptomatic bacteriuria in adults were included...
February 28, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29594953/ceftolozane-tazobactam-for-the-treatment-of-xdr-pseudomonas-aeruginosa-infections
#17
Laura Escolà-Vergé, Carles Pigrau, Ibai Los-Arcos, Ángel Arévalo, Belen Viñado, David Campany, Nieves Larrosa, Xavier Nuvials, Ricard Ferrer, Oscar Len, Benito Almirante
PURPOSE: The aim of this study was to evaluate the effectiveness of ceftolozane/tazobactam (C/T) for treating extensively drug-resistant Pseudomonas aeruginosa (XDR-PA) infections, and to analyze whether high C/T dosing (2 g ceftolozane and 1 g tazobactam every 8 h) and infection source control have an impact on outcome. METHODS: Retrospective study of all consecutive patients treated with C/T for XDR-PA infection at a tertiary referral hospital (November 2015-July 2017)...
March 28, 2018: Infection
https://www.readbyqxmd.com/read/29594799/managing-esbl-producing-enterobacteriaceae-related-urinary-tract-infection-in-primary-care-a-tool-kit-for-general-practitioners
#18
Aurélie Zucconi, Johan Courjon, Christophe Maruéjouls, Fabrice Saintpère, Nicolas Degand, Lilli Pandiani, Christian Pradier, Véronique Mondain
In Southern France, approximately 4% of E. coli isolates from community-acquired urinary tract infections are extended spectrum beta-lactamase producers, while carriage rates for enterobacteriaceae (ESBL-E) range from 3 to 6%. General practitioners (GP) are unfamiliar with the management of patients harboring ESBL-E. Providing them with a specific tool kit should assist in their therapeutic approach and optimize antimicrobial prescription an ESBL-E tool kit was developed by a multidisciplinary team: infectious diseases (ID) specialists, microbiologists, pharmacologists, and nursing home staff...
March 28, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29594008/pregnancy-in-a-woman-with-untreated-bladder-exstrophy-a-case-report
#19
Suhui Wu, Jingfen Sun, Huimin Lv, Yangang Zhang, Haixia Shang, Huajun Zhang, Jerome L Belinson
Objective: To report the management of urinary tract obstruction and infection in a pregnant woman with unrepaired bladder exstrophy. Case Report: A 27-year-old pregnant woman with unrepaired bladder exstrophy was referred to our hospital with a complaint of bilateral flank pain in the second trimester. After two-dimensional abdominal ultrasound, magnetic resonance imaging and a urine analysis, she was diagnosed with an upper urinary tract infection due to ureteral obstruction secondary to unrepaired congenital bladder exstrophy and an intrauterine pregnancy...
January 2018: Case Reports in Women's Health
https://www.readbyqxmd.com/read/29590188/overview-of-systematic-reviews-assessing-the-evidence-for-shorter-versus-longer-duration-antibiotic-treatment-for-bacterial-infections-in-secondary-care
#20
Igho J Onakpoya, A Sarah Walker, Pui S Tan, Elizabeth A Spencer, Oghenekome A Gbinigie, Johanna Cook, Martin J Llewelyn, Christopher C Butler
Our objective was to assess the clinical effectiveness of shorter versus longer duration antibiotics for treatment of bacterial infections in adults and children in secondary care settings, using the evidence from published systematic reviews. We conducted electronic searches in MEDLINE, Embase, Cochrane, and Cinahl. Our primary outcome was clinical resolution. The quality of included reviews was assessed using the AMSTAR criteria, and the quality of the evidence was rated using the GRADE criteria. We included 6 systematic reviews (n = 3,162)...
2018: PloS One
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