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Tranexamic Acid

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https://www.readbyqxmd.com/read/29241383/the-effect-of-prophylactic-oral-tranexamic-acid-plus-buccal-misoprostol-on-blood-loss-after-vaginal-delivery-a-randomized-controlled-trial
#1
Nahla W Shady, Hany F Sallam, Ahmed H Elsayed, Abdelrahman M Abdelkader, Shymaa S Ali, Ahmed Alanwar, Ahmed M Abbas
OBJECTIVE: To evaluate the effect of prophylactic oral tranexamic acid (TA) plus buccal misoprostol on the amount of blood loss after vaginal delivery in women at low risk for postpartum hemorrhage (PPH). MATERIALS AND METHODS: The study was a randomized open label clinical trial conducted in a tertiary University Hospital between January 2016 and June 2017. We included women who delivered vaginally with a singleton pregnancy. They were randomized into three groups: group I (women received 10 IU oxytocin IV after delivery of the baby), group II (women received 600 µg buccal misoprostol after delivery of the baby) and group III (women received 1000 mg oral TA at the end of the first stage of labor plus 600 µg buccal misoprostol after delivery of the baby)...
December 14, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29239953/the-impact-of-prehospital-tranexamic-acid-on-blood-coagulation-in-trauma-patients
#2
Philipp Stein, Jan-Dirk Studt, Roland Albrecht, Stefan Müller, Dieter von Ow, Simon Fischer, Burkhardt Seifert, Sergio Mariotti, Donat R Spahn, Oliver M Theusinger
BACKGROUND: There is limited data on prehospital administration of tranexamic acid (TXA) in civilian trauma. The aim of this study was to evaluate changes in coagulation after severe trauma from on-scene to the hospital after TXA application in comparison to a previous study without TXA. METHODS: The study protocol was registered at ClinicalTrials.gov (NCT02354885). A prospective, multicenter, observational study investigating coagulation status in 70 trauma patients receiving TXA (1 g intravenously) on-scene versus a control group of 38 patients previously published without TXA...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29234620/what-are-the-optimal-dose-of-administration-and-time-of-drainage-for-topical-tranexamic-acid-in-patients-undergoing-cardiac-surgery
#3
Seyed Mahmood Nouraei
No abstract text is available yet for this article.
December 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29232560/the-effect-of-tranexamic-acid-and-gender-on-intraoperative-bleeding-in-orthognathic-surgery-a-randomized-controlled-trial
#4
Jesper Jared Secher, Johannes Jakobsen Sidelmann, Janne Ingerlsev, Jens Jørgen Thorn, Else Marie Pinholt
PURPOSE: The purpose of this randomized trial was to measure the effect of intravenously administered tranexamic acid (TXA) on intraoperative blood loss (IOB) in patients undergoing bimaxillary orthognathic surgery (OS). MATERIALS AND METHODS: The authors designed and implemented a double-blinded placebo-controlled trial composed of patients eligible for OS at the Hospital of South West Denmark (Esbjerg, Denmark) from August 2014 through September 2016. The primary predictor variable was a single intravenous dose of TXA 1 g administered preoperatively or an equivalent saline placebo...
November 21, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29230608/combinatorial-therapy-with-two-pro-coagulants-and-one-osmotic-agent-reduces-the-extent-of-the-lesion-in-the-acute-phase-of-spinal-cord-injury-in-the-rat
#5
Mathieu Boutonnet, Elisabeth Laemmel, Eric Vicaut, Jacques Duranteau, Marc Soubeyrand
BACKGROUND: Spinal cord injury (SCI) is a complex disease that leads to a motor, sensitive, and vegetative impairment. So far, single therapies are ineffective for treating SCI in humans and a multifactorial therapeutic approach may be required. The aim of this work was to assess the effect of a triple therapy (TT) associating two pro-coagulant therapies (tranexamic acid and fibrinogen) with an anti-edema therapy (hypertonic saline solution), on the extent of the lesion 24 h post-injury...
December 11, 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/29221841/risk-factors-for-reaching-the-post-operative-transfusion-trigger-in-a-community-primary-total-knee-arthroplasty-population
#6
Stefano A Bini, Jeanne A Darbinian, William T Brox, Monti Khatod
BACKGROUND: Little data exist to evaluate an individual's pre-operative risk of blood transfusion following total knee arthroplasty (TKA). Our aim is to identify the risk factors associated with reaching the transfusion trigger of Hb <8 g/dL (TT8) following surgery and how perioperative tranexamic acid (TXA) affects that outcome. METHODS: Using a retrospective cohort study design, routine, unilateral TKAs performed between 2011 and 2013 in 19 hospitals were reviewed...
December 5, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29215478/tranexamic-acid-for-lower-gi-hemorrhage-a-randomized-placebo-controlled-clinical-trial
#7
Stephen R Smith, David Murray, Peter G Pockney, Cino Bendinelli, Brian D Draganic, Rosemary Carroll
BACKGROUND: Lower GI hemorrhage is a common source of morbidity and mortality. Tranexamic acid is an antifibrinolytic that has been shown to reduce blood loss in a variety of clinical conditions. Information regarding the use of tranexamic acid in treating lower GI hemorrhage is lacking. OBJECTIVE: The aim of this trial was to determine the clinical efficacy of tranexamic acid when used for lower GI hemorrhage. DESIGN: This was a prospective, double-blind, placebo-controlled, randomized clinical trial...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29201870/factors-that-influence-blood-loss-and-need-for-transfusion-following-total-knee-arthroplasty
#8
Achilleas Boutsiadis, Ryan Jacob Reynolds, Mo Saffarini, Jean-Claude Panisset
Background: Blood loss during total knee arthroplasty (TKA) remains a concern, as many patients require blood transfusions, which increase risks of allergic reactions, disease transmission, and thromboembolisms. The purpose was to determine factors associated with blood loss and need for transfusion in patients receiving routine TKA. Methods: The authors prospectively analyzed 150 consecutive uncemented TKAs for age, gender, body mass index (BMI), anticoagulant medication, type of anesthesia, tranexamic acid (TXA) administration, tourniquet inflation, drain placement, pre- and post-operative Haemoglobin (Hb) level (g/dL), and whether transfusion was necessary...
November 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29200009/antifibrinolytic-therapy-and-perioperative-considerations
#9
Jerrold H Levy, Andreas Koster, Quintin J Quinones, Truman J Milling, Nigel S Key
Fibrinolysis is a physiologic component of hemostasis that functions to limit clot formation. However, after trauma or surgery, excessive fibrinolysis may contribute to coagulopathy, bleeding, and inflammatory responses. Antifibrinolytic agents are increasingly used to reduce bleeding, allogeneic blood administration, and adverse clinical outcomes. Tranexamic acid is the agent most extensively studied and used in most countries. This review will explore the role of fibrinolysis as a pathologic mechanism, review the different pharmacologic agents used to inhibit fibrinolysis, and focus on the role of tranexamic acid as a therapeutic agent to reduce bleeding in patients after surgery and trauma...
December 4, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29194320/no-iv-no-problem-intraosseous-administration-of-tranexamic-acid-is-as-effective-as-intravenous-in-a-porcine-hemorrhage-model
#10
Michael S Lallemand, Donald M Moe, John M McClellan, Michael Loughren, Shannon Marko, Matthew J Eckert, Matthew J Martin
BACKGROUND: The acute coagulopathy of trauma is often accompanied by hyperfibrinolysis. TXA can reverse this phenomenon, and, when given early, decreases mortality from bleeding. Establishing IV access can be difficult in trauma and IO access is often preferred for drug administration. Currently, there is no data on the efficacy of IO administered TXA. Our objectives were to compare serum concentrations of tranexamic acid (TXA) when given IV and intraosseous (IO) and to compare the efficacy of IO administered TXA to IV at reversing hyperfibrinolysis METHODS: Using a porcine hemorrhage and ischemia-reperfusion (IR) model, 18 swine underwent hemorrhagic shock followed by a tissue plasminogen activator (tPA) infusion to induce hyperfibrinolysis...
December 1, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29194278/craniosynostosis-surgery-and-the-impact-of-tranexamic-acid-dosing
#11
Nicole M Kurnik, Lacey R Pflibsen, Annie Do, Ruth Bristol, Davinder J Singh
Consensus does not exist regarding the best dosage regimen for using tranexamic acid (TXA) for patients undergoing open calvarial vault remodeling in craniosynostosis surgery. The purpose of this study was to evaluate 2 dosing protocols, as well as the cost of using TXA. Previously, the institutional protocol was to give patients undergoing open calvarial vault remodeling a loading infusion of TXA (10 mg/kg) at the start of their procedure, after which intravenous TXA (5 mg/kg/h) was given throughout surgery and for 24 hours postoperatively...
November 20, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29193211/is-tranexamic-acid-exposure-related-to-blood-loss-in-hip-arthroplasty-a-pharmacokinetic-pharmacodynamic-study
#12
Julien Lanoiselée, Paul J Zufferey, Edouard Ollier, Sophie Hodin, Xavier Delavenne
AIMS: Tranexamic acid (TXA) is an antifibrinolytic agent, decreasing blood loss in hip arthroplasty. The present study investigated the relationship between TXA exposure markers, including the time above the in vitro threshold reported for inhibition of fibrinolysis (10 mg l-1 ), and perioperative blood loss. METHODS: Data were obtained from a prospective, double-blind, parallel-arm, randomized superiority study in hip arthroplasty. Patients received a preoperative intravenous bolus of TXA 1 g followed by a continuous infusion of either TXA 1 g or placebo over 8 h...
October 26, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29189683/tranexamic-acid-for-the-management-of-obstetric-hemorrhage
#13
Alexander J Butwick, Catherine Deneux-Tharaux, Loic Sentilhes
No abstract text is available yet for this article.
December 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29189568/tranexamic-acid-decreases-visible-and-hidden-blood-loss-without-affecting-prethrombotic-state-molecular-markers-in-transforaminal-thoracic-interbody-fusion-for-treatment-of-thoracolumbar-fracture-dislocation
#14
Wentao Wang, Kun Duan, Minjie Ma, Yong Jiang, Tuanjiang Liu, Jijun Liu, Dingjun Hao
STUDY DESIGN: A randomized, double-blind, placebo-controlled clinical trial OBJECTIVE.: To evaluate the efficacy and safety of tranexamic acid (TXA) administered during the surgical correction of thoracolumbar fracture-dislocation SUMMARY OF BACKGROUND DATA.: Thoracolumbar fracture-dislocation surgery is generally associated with substantial blood loss and a high risk of deep vein thrombosis (DVT). TXA has been shown to improve hemostasis in surgical procedures. METHODS: We investigated 80 patients with thoracolumbar fracture-dislocation who underwent transforaminal thoracic interbody fusion (TTIF) between March 2014 and December 2016...
November 17, 2017: Spine
https://www.readbyqxmd.com/read/29184977/commentary-on-comparison-of-the-effect-of-dexamethasone-and-tranexamic-acid-separately-or-in-combination-on-post-rhinoplasty-and-edema-and-ecchymosis
#15
R Laurence Berkowitz
No abstract text is available yet for this article.
November 28, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29175569/a-randomized-controlled-trial-of-low-dose-tranexamic-acid-versus-placebo-to-reduce-red-blood-cell-transfusion-during-complex-multilevel-spine-fusion-surgery
#16
Louanne M Carabini, Natalie C Moreland, Ryan J Vealey, John F Bebawy, Tyler R Koski, Antoun Koht, Dhanesh K Gupta, Michael J Avram
BACKGROUND: Multilevel spine fusion surgery for adult deformity correction is associated with significant blood loss and coagulopathy. Tranexamic acid reduces blood loss in high risk surgery, but the efficacy of a low dose regimen is unknown. METHODS: Sixty-one patients undergoing multilevel complex spinal fusion with and without osteotomies were randomly assigned to receive low dose tranexamic acid (10 mg/kg loading dose then 1 mg·kg-1·hr-1 throughout surgery) or placebo...
November 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29174746/evaluating-the-effect-on-mortality-of-a-no-tranexamic-acid-txa-policy-for-cardiovascular-surgery
#17
Takuma Maeda, Takuma Ishihara, Shigeki Miyata, Kizuku Yamashita, Hiroaki Sasaki, Junjiro Kobayashi, Yoshihiko Ohnishi, Kunihiro Nishimura, Ayumi Shintani, Hiroyasu Iso
OBJECTIVES: The authors stopped using tranexamic acid (TXA) in April 2013. The present study aimed to examine the impact of a "no-TXA-use" policy by comparing the adverse effects of TXA and clinical outcomes before and after the policy change in patients undergoing cardiovascular surgery. DESIGN: A single center retrospective cohort study. SETTING: A single cardiovascular center. PARTICIPANTS: Patients undergoing cardiovascular surgery between January 2008 and July 2015 (n = 3,535)...
October 13, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29166688/-perioperative-management-in-total-knee-arthroplasty
#18
Robert Hube, Hermann O Mayr, Philipp von Roth, Michael Najfeld, Kathi Thiele
The themes of this paper are the clinical relevance and technique of perioperative management in total knee arthroplasty. Due to the number of unsatisfied patients after knee arthroplasty, optimisation of processes seems to be necessary. Beside patient preparation and rehabilitation, the surgical technique and implant choice in perioperative management are important. This means the use of tourniquet and drains, the application of tranexamic acid and pain management. These items are presented and discussed in detail in this paper...
November 22, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29153864/changes-in-markers-of-thrombin-generation-and-interleukin-6-during-unicondylar-knee-and-total-knee-arthroplasty
#19
Edwin P Su, Lauren E Mount, Allina A Nocon, Thomas P Sculco, George Go, Nigel E Sharrock
BACKGROUND: Total knee arthroplasty (TKA) is associated with a risk of thromboembolism requiring routine thromboprophylaxis, but there is debate about the risk with unicondylar knee arthroplasty (UKA) as it is a more minor procedure. We sought to investigate the relative risk of thromboembolism with UKA compared to TKA and one-staged bilateral TKA (BTKA) by measuring the increase in circulating biochemical markers of thrombin generation during the procedures. Degree of surgical trauma was also assessed by measuring interleukin-6, a marker of metabolic injury...
October 16, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29149971/fibrinolysis-in-living-donor-liver-transplantation-recipients-evaluated-using-thromboelastometry-impact-on-mortality
#20
T Shimauchi, K Yamaura, M Higashi, K Abe, T Yoshizumi, S Hoka
BACKGROUND: Inadequate hemostasis during living donor liver transplantation (LDLT) is mainly due to coagulopathy but may also include fibrinolysis. The purpose of this study was to determine the incidence of fibrinolysis and assess its relevance to mortality in LDLT. METHODS: The incidence and prognosis of fibrinolysis were retrospectively studied in 76 patients who underwent LDLT between April 2010 and February 2013. Fibrinolysis was evaluated and defined by maximum lysis (ML) >15% within a 60-minute run time using thromboelastometry (ROTEM)...
November 2017: Transplantation Proceedings
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