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Tranexamic Acid

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https://www.readbyqxmd.com/read/29050875/subcutaneous-mastectomy-in-female-to-male-transsexuals-optimizing-perioperative-and-operative-management-in-8-years-clinical-experience
#1
Andreas Wolter, Till Scholz, Naja Pluto, Jens Diedrichson, Andreas Arens-Landwehr, Jutta Liebau
INTRODUCTION: The incidence of complications, especially acute hematoma requiring surgical revision in female-to-male transsexuals (FTMTS), is consistently highly documented in literature with up to 33%. Since 2008 we perform subcutaneous mastectomies in FTMTS with an annually increasing number of cases. Due to an initially high hematoma revision rate in the previously published cohort (2008-2013), we implemented peri- and postoperative preventive measures and compared the results with the recent patient cohort (2014-2016)...
September 29, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29050714/when-does-intraoperative-blood-loss-occur-during-pediatric-scoliosis-correction
#2
Sean Wahlquist, Montri Wongworawat, Scott Nelson
BACKGROUND: The purpose of our study was to assess the relationship between amount of blood loss and surgical stage in pediatric patients undergoing posterior spinal fusion for deformity correction to determine: (1) when the highest rate of blood loss occurred; (2) what percentage of total blood loss occurred during deformity correction and closure; and (3) how to predict remaining blood loss during a procedure. Blood loss following exposure and placement of the final pedicle screw is often underestimated, which may result in lack of sufficient blood product availability...
November 2017: Spine Deformity
https://www.readbyqxmd.com/read/29049210/topical-use-of-tranexamic-acid-can-effectively-decrease-hidden-blood-loss-during-posterior-lumbar-spinal-fusion-surgery-a-retrospective-study
#3
Zhinan Ren, Shugang Li, Lin Sheng, Qianyu Zhuang, Zheng Li, Derong Xu, Xin Chen, Pengxiang Jiang, Xiao Zhang
In spinal fusion surgery, total blood loss (TBL) is composed of visible blood loss from the surgical field and wound drainage, and hidden blood loss (HBL). Until now, no published studies exist reporting the effect of topical use of tranexamic acid (tTXA) on HBL in patients undergoing posterior lumbar spinal fusion surgery. This study aimed to explore the effect of tTXA on HBL during primary posterior lumbar spinal fusion surgery. Between September 2014 and September 2016, 100 adult patients (age > 18 years) with lumbar disc herniation or lumbar spinal stenosis undergoing primary posterior lumbar instrumented spinal fusions at 1 institution were divided into tTXA and control groups...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049195/the-efficacy-of-combined-intra-articular-and-intravenous-tranexamic-acid-for-blood-loss-in-primary-total-knee-arthroplasty-a-meta-analysis
#4
Zhao Wang, Xiaofei Shen
BACKGROUND: This meta-analysis aimed to illustrate the efficacy and safety of combined topical and intravenous (IV) tranexamic acid (TXA) for blood loss control in primary total knee arthroplasty (TKA) patients. METHODS: In April 2017, a systematic computer-based search was conducted in PubMed, EMBASE, Web of Science, Cochrane Database of Systematic Reviews, and Google database. Data on patients prepared for TKA surgery in studies that compared combined topical and IV TXA versus placebo, topical, or IV TXA alone were retrieved...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29040203/the-temporal-response-and-mechanism-of-action-of-tranexamic-acid-in-endothelial-glycocalyx-degradation
#5
Mark E Diebel, Jonathan V Martin, David M Liberati, Lawrence N Diebel
BACKGROUND: The endothelial glycocalyx (GCX) plays an important role in vascular barrier function. Damage to the GCX occurs due to a variety of causes including hypoxia, ischemia-reperfusion, stress related sympathoadrenal activation, and inflammation. Tranexamic acid (TXA) may prevent GCX degradation. The therapeutic window for TXA administration and the mechanism of action has been under review. Membrane-anchored proteases (sheddases) are key components in endothelial cell biology including the regulation of vascular permeability...
October 16, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29039330/comparison-of-tranexamic-acid-pharmacokinetics-after-intra-articular-and-intravenous-administration-in-rabbits
#6
Gen-Xiang Rong, Chen-Lin Shen, Bin-Jie Gui, Hao Yin, Zhi Tang
Tranexamic Acid (TXA) is commonly administered in total knee arthroplasty for reducing blood loss. There has been a growing interest in the topical use of TXA except intravenous use for prevention of bleeding in TKA. The aim of this study was to develop and validate a HPLC-MS method to detect TXA and apply to compare the pharmacokinetic profile of TXA after intravenous (IV) and topical intra-articular (IA) application of TXA at a dose of 20 mg/kg in rabbits. In order to prove intra-articular administration is better than that of intravenous administration from the point of rabbit pharmacokinetic...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29027510/comparing-the-efficacy-of-topical-hydroquinone-2-vs-intradermal-tranexamic-acid-microinjections-in-treating-melasma-a-split-face-controlled-trial
#7
Nasrin Saki, Mohammad Darayesh, Alireza Heiran
INTRODUCTION: Melasma is a benign, acquired, and chronic hypermelanosis. Topical hydroquinone (HQ) is a conventional choice to treat melasma. Tranexamic acid (TA) is a relatively new brightening agent that interferes with keratinocyte- melanocyte interactions. The aim of the present study was to compare the efficacy and safety of TA intradermal injections with HQ in treating melasma. MATERIALS AND METHODS: In this split-face controlled trial, thirty-seven patients were randomized to receive three monthly sessions of TA intradermal injections either on the right or the left side of their face, and topical HQ once a night for three months on the other side...
October 13, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29027188/transfusion-rate-using-intravenous-tranexamic-acid-in-hip-revision-surgery
#8
Pablo Mariani, Martin A Buttaro, Pablo A Slullitel, Fernando M Comba, Gerardo Zanotti, Pablo Ali, Francisco Piccaluga
INTRODUCTION: Hip revision surgery is associated with a high probability of the necessity for a blood transfusion. Different studies support the use of tranexamic acid (TXA) to decrease the rate of transfusions in primary hip surgery. Nevertheless, the use of this drug in hip revision surgery has not yet been widely accepted. The aim of our study was to establish the rate of blood transfusion with and without TXA in hip revision surgery. METHODS: We retrospectively studied 125 hip revision surgery patients operated on between 2011 and 2014...
October 12, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29025850/protocol-for-a-pilot-randomised-double-blinded-placebo-controlled-trial-of-prophylactic-use-of-tranexamic-acid-for-preventing-postpartum-haemorrhage-tapph-1
#9
Asim Alam, Ameya Bopardikar, Shelly Au, Jon Barrett, Jeannie Callum, Alex Kiss, Stephen Choi
INTRODUCTION: Postpartum haemorrhage (PPH) is the leading cause of maternal morbidity and mortality worldwide. Despite the availability of multiple uterotonic agents, the incidence of PPH continues to rise. Tranexamic acid (TXA) has been shown to be a safe, effective and inexpensive therapeutic option for the treatment of PPH, however, its use prophylactically in mitigating the risk of PPH is unknown. This pragmatic randomised prospective trial assesses the feasibility and safety of administering TXA at the time of delivery for the prevention of PPH...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29016673/a-systematic-review-and-meta-analysis-comparing-combined-intravenous-and-topical-tranexamic-acid-with-intravenous-administration-alone-in-tha
#10
REVIEW
Yangbai Sun, Chaoyin Jiang, Qingfeng Li
PURPOSE: To compare the effectiveness and safety of combined intravenous and topical tranexamic acid with intravenous use alone in THA. METHODS: The electronic databases MEDLINE, EMBASE, BIOSIS, Cochrane central, and further adapted for Google and Google Scholar internet, last updated on Dec 30, 2016, were searched. Evaluated outcomes included total blood loss, transfusion rate, maximum postoperative Hb drop, and incidence of thromboembolic complications. The standard mean difference (SMD) or the relative risk (RR) was calculated for continuous or dichotomous data respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28993489/civilian-and-military-doctors-knowledge-of-tranexamic-acid-txa-use-in-major-trauma-a-comparison-study
#11
Jonathan Blair Thomas Herron, R French, A D Gilliam
INTRODUCTION: Tranexamic acid (TXA) administration within the recommended time of 3 hours has been demonstrated to improve outcomes following trauma. The aim of this study was to identify potential knowledge gaps in the administration of TXA in order to target further educational training in those doctors responsible for the management of acute trauma. METHODS: 104 military and 852 civilian doctors were invited to complete a four-item web-based questionnaire pertaining to the indications, dose, side effects and evidence base for TXA administration in trauma...
October 9, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/28987501/composite-alginate-hyaluronan-sponges-for-the-delivery-of-tranexamic-acid-in-post-extractive-alveolar-wounds
#12
Ovidio Catanzano, Vittoria D'Esposito, Pietro Formisano, Joshua S Boateng, Fabiana Quaglia
The management of wounds in patients on anticoagulant therapy who require oral surgical procedures is problematic and often results in a non-satisfactory healing process. Here we report a method to prepare an advanced dressing able to avoid uncontrolled bleeding by occluding the post-extractive alveolar wounds, and simultaneously, capable of a fast release of tranexamic acid (TA). Composite alginate/hyaluronan (ALG/HA) sponge dressings loaded with TA were prepared by a straightforward internal gelation method followed by a freeze-drying step...
October 5, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28987494/randomized-placebo-controlled-double-blind-study-of-oral-tranexamic-acid-in-the-treatment-of-moderate-to-severe-melasma
#13
Eunice Del Rosario, Stephanie Florez-Pollack, Lucio Zapata, Katia Hernandez, Andrea Tovar-Garza, Michelle Rodrigues, Linda S Hynan, Amit G Pandya
BACKGROUND: Melasma is a common pigmentary disorder that is often difficult to treat. Tranexamic acid (TA) has emerged as a promising treatment for melasma; however, few controlled studies exist. OBJECTIVE: To determine the efficacy of oral TA in patients with moderate to severe melasma METHODS: Patients with moderate to severe melasma were treated with 250 mg of TA or placebo capsules twice daily for 3 months and sunscreen followed by 3 months of treatment with sunscreen only...
October 4, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28987273/tranexamic-acid-impairs-hippocampal-synaptic-transmission-mediated-by-gamma-aminobutyric-acid-receptor-type-a
#14
Hedwig Irl, Stephan Kratzer, Stefan Schwerin, Eberhard Kochs, Manfred Blobner, Gerhard Schneider, Gerhard Rammes, Rainer Haseneder
High-dose application of tranexamic acid (TXA), a widely used antifibrinolytic drug, can cause seizures in patients undergoing surgery. Mechanistically, seizures are considered to arise from an imbalance between inhibitory and excitatory synaptic transmission, whose main transmitters are gamma-aminobutyric acid (GABA) and glutamate. In the present study, we investigated the effects of TXA on neuronal excitability and synaptic transmission in the hippocampus, a structure that plays a pivotal role in human epilepsy...
October 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28983887/effect-of-tranexamic-acid-use-on-blood-loss-and-thromboembolic-risk-in-hip-fracture-surgery-systematic-review-and-meta-analysis
#15
Dinnish Baskaran, Syed Rahman, Yousuf Salmasi, Saied Froghi, Onur Berber, Marc George
INTRODUCTION: Intravenous tranexamic acid (IV TXA) is a recognised pharmaceutical intervention utilised to minimise blood loss and allogenic blood transfusion. However, the use of IV TXA in hip fracture surgery remains inconclusive. We conducted a meta-analysis to investigate the role of TXA in operative hip fracture management on operative and total blood loss, allogenic blood transfusion requirements and impact on venous thromboembolic (VTE) event incidence. METHODS: A systematic computerised literature search of PubMed, Medline, Embase, Ovid, The Cochrane Controlled Trials Register, Trip and Google was conducted...
October 4, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28980475/comparison-of-oral-and-intravenous-tranexamic-acid-for-prevention-of-perioperative-blood-loss-in-total-knee-and-total-hip-arthroplasty
#16
Mary Alice Gortemoller, Bryan Allen, Rochelle Forsyth, Kimberly Theiss, Kristal Cunningham, Calvin Tucker
BACKGROUND: Tranexamic acid (TA) is an antifibrinolytic agent that prevents perioperative blood loss in patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA). This benefit has been established with the intravenous (IV) dosage form, but there is limited evidence evaluating oral TA in this setting. OBJECTIVE: To compare the effect of oral versus IV TA on perioperative blood loss in those undergoing TKA or THA. METHODS: In this single-centered retrospective chart review, participants at least 18 years of age who received IV or oral TA from a single surgeon who performed their THA or TKA were included...
October 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28980055/comparison-of-the-effect-of-dexamethasone-and-tranexamic-acid-separately-or-in-combination-on-post-rhinoplasty-edema-and-ecchymosis
#17
Mohammad Mehdizadeh, Alireza Ghassemi, Mohammad Khakzad, Mehrafza Mir, Leili Nekoohesh, Aliakbar Moghadamnia, Ali Bijani, Zahra Mehrbakhsh, Hosein Ghanepur
BACKGROUND: Dexamethasone and tranexamic acid are used to decrease post-rhinoplasty periorbital edema and ecchymosis. We compared the impact of each medication separately or in combination in this regard. METHODS: A prospective, randomized triple-blinded study was undertaken on 60 patients who underwent primary open rhinoplasty. They were divided into four groups: Group D (n = 15) received 8 mg dexamethasone, group T (n = 15) received 10 mg/kg tranexamic acid, group DT (n = 15) received both 8 mg dexamethasone and 10 mg/kg tranexamic acid, and group P (n = 15) received neither medication and served as the placebo control group...
October 4, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28979607/application-of-tranexamic-acid-in-total-knee-arthroplasty-prospective-randomized-trial
#18
Joao Paulo Fernandes Guerreiro, Bruno Scatolon Badaro, Jose Rodolfo Martines Balbino, Marcus Vinicius Danieli, Alexandre Oliveira Queiroz, Daniele Cristina Cataneo
BACKGROUND: The use of tranexamic acid (TXA) in total knee arthroplasty (TKA) has shown good results. Bleeding may cause local complications consequently greater pain and reduced function postoperatively. No study has related the use of TXA to these facts. OBJECTIVE: The aim was to evaluate the effects of TXA haemoglobin, Western Ontario and McMaster Universities Index (WOMAC), pain intensity and flexion gain after TKA. METHODS: 43 patients were randomized and then underwent TKA...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28976628/the-recommended-dose-of-idarucizumab-may-not-always-be-sufficient-for-sustained-reversal-of-dabigatran-comment
#19
Luke Yip, Jou-Fang Deng
We read with interest the case report by Simon et al highlighting the pharmacokinetics and pharmacodynamics of idarucizumab and dabigatran in a patient with chronic renal disease who was on therapeutic dabigatran dosing, developed acute kidney injury and serious rectal hemorrhaging.[1] The management of this patient in this clinical scenario merits further discussion. It is curious that a patient on therapeutic dabigatran dosing and develops acute kidney injury and serious hemorrhaging received multiple pack red blood cells, two doses of tranexamic acid, platelets, and a single dose of idarucizumab but not blood component therapy such as prothrombin complex concentrate or activated prothrombin complex concentrate...
October 4, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28976426/blood-conservation-using-tranexamic-acid-is-not-superior-to-epsilon-aminocaproic-acid-after-total-knee-arthroplasty
#20
RANDOMIZED CONTROLLED TRIAL
Clifford Kent Boese, Leslie Centeno, Ryan W Walters
BACKGROUND: Epsilon-aminocaproic acid (EACA) and tranexamic acid (TXA) are synthetic amino acid derivatives that interfere with fibrinolysis, promoting hemostasis by pharmacological means. Although both drugs have been shown to decrease blood loss with a minimal risk of thromboembolic adverse events following cardiac and vascular surgery, we are aware of only 1 published trial that directly compared the antifibrinolytic effects of EACA with those of TXA after total knee arthroplasty (TKA)...
October 4, 2017: Journal of Bone and Joint Surgery. American Volume
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