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https://www.readbyqxmd.com/read/28429185/high-content-assessment-of-cardiac-function-using-heart-on-a-chip-devices-as-drug-screening-model
#1
Genevieve Conant, Benjamin Fook Lun Lai, Rick Xing Ze Lu, Anastasia Korolj, Erika Yan Wang, Milica Radisic
Drug discovery and development continues to be a challenge to the pharmaceutical industry despite great advances in cell and molecular biology that allow for the design of better targeted therapeutics. Many potential drug compounds fail during the clinical trial due to inefficacy and toxicity that were not predicted during preclinical stages. The fundamental problem lies with the use of traditional drug screening models that still largely rely on the use of cell lines or animal cell monolayers, which leads to lack of predictive power of human tissue and organ response to the drug candidates...
April 20, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28423969/process-evaluation-of-the-type-2-diabetes-mellitus-pulse-program-randomized-controlled-trial-recruitment-engagement-and-overall-satisfaction
#2
Elroy J Aguiar, Philip J Morgan, Clare E Collins, Ronald C Plotnikoff, Myles D Young, Robin Callister
BACKGROUND: Men are underrepresented in weight loss and type 2 diabetes mellitus (T2DM) prevention studies. PURPOSE: To determine the effectiveness of recruitment, and acceptability of the T2DM Prevention Using LifeStyle Education (PULSE) Program-a gender-targeted, self-administered intervention for men. METHODS: Men (18-65 years, high risk for T2DM) were randomized to intervention ( n = 53) or wait-list control groups ( n = 48). The 6-month PULSE Program intervention focused on weight loss, diet, and exercise for T2DM prevention...
April 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28421600/lay-led-and-peer-support-interventions-for-adolescents-with-asthma
#3
REVIEW
Kayleigh M Kew, Robin Carr, Iain Crossingham
BACKGROUND: Adolescents with asthma are at high risk of poor adherence with treatment. This may be compounded by activities that worsen asthma, in particular smoking. Additional support above and beyond routine care has the potential to encourage good self-management. We wanted to find out whether sessions led by their peers or by lay leaders help to reduce these risks and improve asthma outcomes among adolescents. OBJECTIVES: To assess the safety and efficacy of lay-led and peer support interventions for adolescents with asthma...
April 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28413055/functional-genomics-and-high-content-screening-in-the-nervous-system
#4
EDITORIAL
Jessica K Lerch, William Buchser
No abstract text is available yet for this article.
April 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28409012/enhancing-the-diagnosis-of-fabry-disease-in-cardiology-with-a-targeted-information-a-before-after-control-impact-study
#5
Anne-Louise Savary, Remy Morello, Carole Brasse-Lagnel, Paul Milliez, Soumeya Bekri, Fabien Labombarda
BACKGROUND: Cardiac complications in Fabry disease are frequent and dominated by a high frequency of left ventricular hypertrophy; therefore, cardiologists may have an essential role in screening for this disease. Providing cardiologists with targeted information on Fabry disease would be valuable and could reduce both diagnostic and therapeutic delays. The aim of this study was to evaluate the efficiency of such strategy for Fabry screening. METHODS: We conducted a before-after control-impact study by comparing observations made before and after targeted information on Fabry disease among cardiologists...
2017: Open Heart
https://www.readbyqxmd.com/read/28405911/a-new-biopesticide-from-a-local-bacillus-thuringiensis-var-tenebrionis-xd3-against-alder-leaf-beetle-coleoptera-chrysomelidae
#6
Ardahan Eski, İsmail Demir, Kazım Sezen, Zihni Demirbağ
Use of chemical pesticides in agriculture harms humans, non-target organisms and environments, and causes increase resistance against chemicals. In order to develop an effective bio-pesticide against coleopterans, particularly against Agelastica alni (Coleoptera: Chrysomelidae) which is one of the serious pests of alder leaf and hazelnut, we tested the insecticidal effect of 21 Bacillus isolates against the larvae and adults of the pest. Bacillus thuringiensis var. tenebrionis-Xd3 (Btt-Xd3) showed the highest insecticidal effect based on screening tests...
May 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28403852/health-workers-perceptions-and-attitude-about-ghana-s-preparedness-towards-preventing-containing-and-managing-ebola-virus-disease
#7
Philip Baba Adongo, Philip Teg-Nefaah Tabong, Emmanuel Asampong, Joana Ansong, Magda Robalo, Richard M Adanu
BACKGROUND: Ebola virus is highly infectious and the disease can be very fatal. The World Health Organization has declared the 2014-2015 Ebola Virus Disease outbreak a Public Health Emergency of International Concern. In response to this, preparations were made in various health facilities and entry points across Ghana. This study explored health workers perceptions, and attitude about Ghana's preparedness towards preventing and containing Ebola Virus Disease. METHODS: We conducted a qualitative study in five (5) of the ten (10) regions in Ghana...
April 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28402311/polishing-of-municipal-secondary-effluent-using-native-microalgae-consortia
#8
Julio César Beltrán-Rocha, Icela Dagmar Barceló-Quintal, Magdalena García-Martínez, Luis Osornio-Berthet, Nidia Saavedra-Villarreal, Juan Villarreal-Chiu, Ulrico Javier López-Chuken
This work evaluates the use of native microalgae consortia for a dual role: polishing treatment of municipal wastewater effluents and microalgae biomass feedstock potential for biodiesel or biofertilizer production. An initial screening was undertaken to test N and P removal from secondary effluents and biomass production by 12 consortia. A subsequent treatment was performed by selected consortia (01 and 12) under three operational conditions: stirring (S), S + 12 h of daily aeration (S + A) and S + A enriched with CO2 (S + AC)...
April 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28402035/screening-and-investigation-lactobacillius-spp-to-improve-secale-cereale-silage-quality
#9
Hye Sun Kim, Ouk Kyu Han, Sam Churl Kim, Min Jung Kim, Youn-Sig Kwak
Silage is a high-moisture-content forage that is used to feed livestock. Using silage as feed is economically feasible and suitable for cattle management. Secale cereale is considered as a high-quality forage plant. After the heading stage the biomass of S. cereale increases by up to 30%; however, lignification in the cell wall causes low fermentation efficiency and coefficient digestibility, and it may also be contaminated by mycotoxin-producing fungi and can impair the quality of the silage. Therefore, the aim of this study was to screen beneficial Lactobacillius spp...
April 12, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28401619/non-compliance-to-infectious-disease-deferral-criteria-among-hong-kong-s-blood-donors
#10
S S Lee, E K H Cheung, J N S Leung, C K Lee
BACKGROUND AND OBJECTIVES: Donor screening alone cannot eliminate the risk of transfusion-transmitted HIV infection. Donor deferral according to established criteria is a supplemental strategy, which has focused largely on men who have sex with men (MSM). A study was conducted to determine the compliance of non-MSM donors with such criteria and examine its implications on blood safety. MATERIALS AND METHODS: Chinese donors who have just donated blood at blood donor centres in Hong Kong were recruited...
April 11, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28401382/first-application-of-newly-developed-ft-nir-spectroscopic-methodology-to-predict-authenticity-of-extra-virgin-olive-oil-retail-products-in-the-usa
#11
Magdi M Mossoba, Hormoz Azizian, Ali Reza Fardin-Kia, Sanjeewa R Karunathilaka, John K G Kramer
Economically motivated adulteration (EMA) of extra virgin olive oils (EVOO) has been a worldwide problem and a concern for government regulators for a long time. The US Food and Drug Administration (FDA) is mandated to protect the US public against intentional adulteration of foods and has jurisdiction over deceptive label declarations. To detect EMA of olive oil and address food safety vulnerabilities, we used a previously developed rapid screening methodology to authenticate EVOO. For the first time, a recently developed FT-NIR spectroscopic methodology in conjunction with partial least squares analysis was applied to commercial products labeled EVOO purchased in College Park, MD, USA to rapidly predict whether they are authentic, potentially mixed with refined olive oil (RO) or other vegetable oil(s), or are of lower quality...
April 11, 2017: Lipids
https://www.readbyqxmd.com/read/28397941/cytotoxicity-anticancer-activities-of-anastrozole-against-breast-liver-hepatocellular-and-prostate-cancer-cells
#12
Firas Hassan, Gamal A El-Hiti, Mays Abd-Allateef, Emad Yousif
To investigate the cytotoxic effect of anastrozole on breast (MCF7), liver hepatocellular (HepG2), and prostate (PC3) cancer cells. Methods: This is a prospective study. Anastrozole's mechanism of apoptosis in living cells was also determined by high content screening (HCS) assay. Methylthiazol tetrazolium (MTT) assay was carried out at the Centre of Biotechnology Research's, Al-Nahrain University, Baghdad, Iraq between July 2015 and October 2015. The HCS assay was performed at the Centre for Natural Product Research  and Drug Discovery, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia between November 2015 and February 2016...
April 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28394930/analysis-of-host-microrna-function-uncovers-a-role-for-mir-29b-2-5p-in-shigella-capture-by-filopodia
#13
Ushasree Sunkavalli, Carmen Aguilar, Ricardo Jorge Silva, Malvika Sharan, Ana Rita Cruz, Caroline Tawk, Claire Maudet, Miguel Mano, Ana Eulalio
MicroRNAs play an important role in the interplay between bacterial pathogens and host cells, participating as host defense mechanisms, as well as exploited by bacteria to subvert host cellular functions. Here, we show that microRNAs modulate infection by Shigella flexneri, a major causative agent of bacillary dysentery in humans. Specifically, we characterize the dual regulatory role of miR-29b-2-5p during infection, showing that this microRNA strongly favors Shigella infection by promoting both bacterial binding to host cells and intracellular replication...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28391735/diet-derived-changes-by-sourdough-fermented-rye-bread-in-exhaled-breath-aspiration-ion-mobility-spectrometry-profiles-in-individuals-with-mild-gastrointestinal-symptoms
#14
Kaisa Raninen, Jenni Lappi, Mikko Kolehmainen, Marjukka Kolehmainen, Hannu Mykkänen, Kaisa Poutanen, Olavi Raatikainen
The potential of utilising exhaled breath volatile organic compound (VOC) profiles in studying diet-derived metabolic changes was examined. After a four-week initial diet period with white wheat bread (WW), seven participants received in randomised order high-fibre diets containing sourdough whole grain rye bread (WGR) or white wheat bread enriched with bioprocessed rye bran (WW + BRB), both for 4 weeks. Alveolar exhaled breath samples were analysed with ChemPro(®)100i analyser (Environics OY, Mikkeli, Finland) at the end of each diet period in fasting state and after a standardised meal...
April 9, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28387709/screening-for-cd-safe-cultivars-of-chinese-cabbage-and-a-preliminary-study-on-the-mechanisms-of-cd-accumulation
#15
Jingjie Wang, Nan Yu, Guangmao Mu, Kamran I Shinwari, Zhenguo Shen, Luqing Zheng
With the rapid progress of industrialization, the effects of environmental contamination on plant toxicity, and subsequently on human health, is a growing concern. For example, the heavy metal pollution of soil such as that caused by cadmium (Cd) is a serious threat. Therefore, screening for pollution-safe edible plants is an essential approach for growing plants under heavy metal-contaminated soils. In the current study, 35 Chinese cabbage (Brassica pekinensis L.) cultivars were selected with the aim of screening for Cd-safe cultivars (CSCs), analyzing their safety, and exploring the mechanism of Cd accumulation...
April 7, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28381964/biological-control-of-bacterial-fruit-blotch-of-watermelon-pathogen-acidovorax-citrulli-with-rhizosphere-associated-bacteria
#16
Mahesh Adhikari, Dil Raj Yadav, Sang Woo Kim, Young Hyun Um, Hyun Seung Kim, Seong Chan Lee, Jeong Young Song, Hong Gi Kim, Youn Su Lee
Bacterial fruit blotch (BFB), which is caused by Acidovorax citrulli, is a serious threat to watermelon growers around the world. The present study was conducted to screen effective rhizobacterial isolates against 35 different A. citrulli isolates and determine their efficacy on BFB and growth parameters of watermelon. Two rhizobacterial isolates viz. Paenibacillus polymyxa (SN-22), Sinomonas atrocyanea (NSB-27) showed high inhibitory activity in the preliminary screening and were further evaluated for their effect on BFB and growth parameters of three different watermelon varieties under greenhouse conditions...
April 2017: Plant Pathology Journal
https://www.readbyqxmd.com/read/28381523/human-milk-oligosaccharide-composition-predicts-risk-of-necrotising-enterocolitis-in-preterm-infants
#17
Chloe A Autran, Benjamin P Kellman, Jae H Kim, Elizabeth Asztalos, Arlin B Blood, Erin C Hamilton Spence, Aloka L Patel, Jiayi Hou, Nathan E Lewis, Lars Bode
OBJECTIVE: Necrotising enterocolitis (NEC) is one of the most common and often fatal intestinal disorders in preterm infants. Markers to identify at-risk infants as well as therapies to prevent and treat NEC are limited and urgently needed. NEC incidence is significantly lower in breast-fed compared with formula-fed infants. Infant formula lacks human milk oligosaccharides (HMO), such as disialyllacto-N-tetraose (DSLNT), which prevents NEC in neonatal rats. However, it is unknown if DSLNT also protects human preterm infants...
April 5, 2017: Gut
https://www.readbyqxmd.com/read/28378423/detecting-pkd1-variants-in-polycystic-kidney-disease-patients-by-single-molecule-long-read-sequencing
#18
Daniel M Borràs, Rolf Vossen, Michael Liem, Henk P J Buermans, Hans Dauwerse, Dave van Heusden, Ron T Gansevoort, Johan T den Dunnen, Bart Janssen, Dorien J M Peters, Monique Losekoot, Seyed Yahya Anvar
A genetic diagnosis of autosomal dominant polycystic kidney disease (ADPKD) is challenging due to allelic heterogeneity, high GC-content, and homology of the PKD1 gene with six pseudogenes. Short-read next-generation sequencing (NGS) approaches, such as whole genome (WGS) and whole exome sequencing (WES), often fail at reliably characterizing complex regions such as PKD1. However, long-read single-molecule sequencing has been shown to be an alternative strategy that could overcome PKD1 complexities and discriminate between homologous regions of PKD1 and its pseudogenes...
April 4, 2017: Human Mutation
https://www.readbyqxmd.com/read/28376796/ahcoda-db-a-data-repository-with-web-based-mining-tools-for-the-analysis-of-automated-high-content-mouse-phenomics-data
#19
Bastijn Koopmans, August B Smit, Matthijs Verhage, Maarten Loos
BACKGROUND: Systematic, standardized and in-depth phenotyping and data analyses of rodent behaviour empowers gene-function studies, drug testing and therapy design. However, no data repositories are currently available for standardized quality control, data analysis and mining at the resolution of individual mice. DESCRIPTION: Here, we present AHCODA-DB, a public data repository with standardized quality control and exclusion criteria aimed to enhance robustness of data, enabled with web-based mining tools for the analysis of individually and group-wise collected mouse phenotypic data...
April 4, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28375027/characterisation-of-data-resources-for-in-silico-modelling-benchmark-datasets-for-adme-properties
#20
K R Przybylak, J C Madden, E Covey-Crump, L Gibson, C Barber, M Patel, M T D Cronin
The cost of in vivo and in vitro screening of ADME properties of compounds has motivated efforts to develop a range of in silico models. At the heart of the development of any computational model are the data; high quality data are essential for developing robust and accurate models. The characteristics of a dataset, such as its availability, size, format and type of chemical identifiers used, influence the modelability of the data. Areas covered: This review explores the usefulness of publicly available ADME datasets for researchers to use in the development of predictive models...
April 4, 2017: Expert Opinion on Drug Metabolism & Toxicology
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