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Mental fatigue

Gregory Plotnikoff, Melissa Barber
INTRODUCTION: Single-disorder or single-organ-system clinical practice guidelines are often of limited usefulness in guiding effective management of patients with chronic multidimensional signs and symptoms. The presence of multiple long-standing medical problems in a given patient despite intensive medical effort suggests that addressing systemic core imbalances could complement more narrowly focused approaches. CASE PRESENTATION: A 72-year-old man experiencing longstanding depression, fatigue, irritable bowel syndrome, and chronic pain in the context of additional refractory illnesses was assessed and treated, guided by a system-oriented approach to underlying core imbalances termed functional medicine...
October 14, 2016: Permanente Journal
Vibeke Strand, Eun Bong Lee, Roy Fleischmann, Rieke E Alten, Tamas Koncz, Samuel H Zwillich, David Gruben, Bethanie Wilkinson, Sriram Krishnaswami, Gene Wallenstein
OBJECTIVES: To compare patient-reported outcomes (PROs) in methotrexate (MTX)-naive patients (defined as no prior treatment or ≤3 doses) receiving tofacitinib versus MTX. METHODS: In the 24-month, phase III, randomised, controlled, ORAL Start trial (NCT01039688), patients were randomised 2:2:1 to receive tofacitinib 5 mg two times per day (n=373), tofacitinib 10 mg two times per day (n=397) or MTX (n=186). PROs assessed included Patient Global Assessment of disease (PtGA), pain, Health Assessment Questionnaire-Disability Index (HAQ-DI), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) and health-related quality of life (Short Form-36 [SF-36])...
2016: RMD Open
Marie-Hélène Pilon, Stéphane Poulin, Marie-Pierre Fortin, Michèle Houde, Louis Verret, Rémi W Bouchard, Robert Laforce
Few studies have explored the rate of cognitive decline and caregiver burden within the context of a specialized memory clinic. When this was done, the focus was largely on functional decline related to Alzheimer's disease (AD). Our goal was to compare the longitudinal decline of AD patients to those with Vascular Dementia (VaD) on Mini-Mental State Examination (MMSE). We further explored the differential impact on caregiver burden. We retrospectively studied 237 charts from patients seen at our Memory Clinic between 2006 and 2012...
March 11, 2016: Neurology (ECronicon)
Nick Lawson, Chung-Han Hsieh, Dana March, Xinnan Wang
Chronic Fatigue Syndrome (CFS) is a debilitating disease characterized by physical and mental exhaustion. The underlying pathogenesis is unknown, but impairments in certain mitochondrial functions have been found in some CFS patients. To thoroughly reveal mitochondrial deficiencies in CFS patients, here we examine the key aspects of mitochondrial function in blood cells from a paired CFS patient-control series. Surprisingly, we discover that in patients the ATP levels are higher and mitochondrial cristae are more condensed compared to their paired controls, while the mitochondrial crista length, mitochondrial size, shape, density, membrane potential, and enzymatic activities of the complexes in the electron transport chain remain intact...
2016: Journal of Nature and Science
Markus K Schuler, Leopold Hentschel, Wadim Kisel, Michael Kramer, Felicitas Lenz, Beate Hornemann, Julia Hoffmann, Stephan Richter, Gerhard Ehninger, Martin Bornhäuser, Frank Kroschinsky
CONTEXT: Physical exercise can alleviate cancer related fatigue. Randomized controlled trials (RCT) in patients with advanced cancer are scarce. OBJECTIVES: We test the impact of a structured, individual sports program on fatigue in patients with advanced cancer. METHODS: 77 patients were invited to participate in this RCT exploring the effects of physical exercises on fatigue 12 and 24 weeks after baseline. Patients were randomized into three groups...
October 12, 2016: Journal of Pain and Symptom Management
Nooshin Atashfeshan, Hamideh Razavi
OBJECTIVE: Analysis of the effect of mental fatigue on a cognitive task and determination of the right start time for rest breaks in work environments. BACKGROUND: Mental fatigue has been recognized as one of the most important factors influencing individual performance. Subjective and physiological measures are popular methods for analyzing fatigue, but they are restricted to physical experiments. Computational cognitive models are useful for predicting operator performance and can be used for analyzing fatigue in the design phase, particularly in industrial operations and inspections where cognitive tasks are frequent and the effects of mental fatigue are crucial...
October 13, 2016: Human Factors
Ashley Craig, Rebecca Guest, Yvonne Tran, James Middleton
Spinal cord injury (SCI) is believed to be associated with high rates of cognitive impairment which can result in complications in recovery. This study concerned two groups of adults with SCI. The first sample involved 150 participants with SCI who were assessed once for cognitive capacity with comparisons made to 45 able-bodied adults. Sample 2 were drawn from Sample 1, and included 88 participants with SCI who were prospectively assessed for mood states (anxiety, depressive mood and fatigue) and pain intensity at three time periods: at admission to SCI rehabilitation, at discharge and 6 months after transition into the community...
October 7, 2016: Journal of Neurotrauma
Glenn S Pransky, Jean-Baptise Fassier, Elyssa Besen, Peter Blanck, Kerstin Ekberg, Michael Feuerstein, Fehmidah Munir
Introduction Many disability prevention strategies are focused on acute injuries and brief illness episodes, but there will be growing challenges for employers to manage circumstances of recurrent, chronic, or fluctuating symptoms in an aging workforce. The goal of this article is to summarize existing peer-review research in this area, compare this with employer discourse in the grey literature, and recommend future research priorities. Methods The authors participated in a year-long sponsored collaboration that ultimately led to an invited 3-day conference, "Improving Research of Employer Practices to Prevent Disability", held October 14-16, 2015, in Hopkinton, Massachusetts, USA...
October 4, 2016: Journal of Occupational Rehabilitation
Carolyn L Deans, Emma L Little
CONTEXT: This article explores the relevance of the body of military psychology knowledge to the management and support of those living and working in rural/remote industries and locations, particularly within Australia. ISSUES: For those who live and work in rural/remote settings, there are social, occupational, health and environmental challenges. Some of these are shared with families and individuals who are associated with military life. The published literature on the shared attributes between military and rural/remote work environments rarely makes a direct link...
October 2016: Rural and Remote Health
Rafael Azevedo, Marcos David Silva-Cavalcante, Bruno Gualano, Adriano E Lima-Silva, Romulo Bertuzzi
PURPOSE: To examine the effects of caffeine ingestion on physiological and perceptual responses in mentally fatigued individuals. METHODS: Eight male physically active subjects completed four cycling constant-workload tests in four experimental conditions at 80 % of maximal power output: control (C), mental fatigue (MF), mental fatigue plus caffeine ingestion (5 mg/kg) (MF-CAF), and mental fatigue plus placebo (MF-PLA). The mental fatigue was induced by a continuous performance task A-X version (AX-CPT)...
September 30, 2016: European Journal of Applied Physiology
Qingmin Feng, Shenglin Liu, Lei Yang, Mingxing Xie, Qiang Zhang
OBJECTIVE: Studies from industrialized countries show that musculoskeletal disorders (MSD) occur commonly in sonographers. However, little is known about sonographers in China, where the awareness of ergonomics and MSD, workload, and available equipment/facilities may differ. We aimed to investigate the prevalence of MSD and associated risk factors in sonographers in central China. METHODS: A cross-sectional survey was conducted with 381 sonographers from 14 randomly selected tertiary hospitals in Hubei province, central China...
2016: PloS One
Yeonsu Song, Donna L Washington, Elizabeth M Yano, Susan M McCurry, Constance H Fung, Joseph M Dzierzewski, Juan Carlos Rodriguez, Stella Jouldjian, Michael N Mitchell, Cathy A Alessi, Jennifer L Martin
OBJECTIVE/BACKGROUND: To identify caregiving-related sleep problems and their relationship to mental health and daytime function in female Veterans. PARTICIPANTS: Female Veterans (N = 1,477) from cross-sectional, nationwide, postal survey data. METHODS: The survey respondent characteristics included demographics, comorbidity, physical activity, health, use of sleep medications, and history of sleep apnea. They self-identified caregiving- related sleep problems (i...
October 3, 2016: Behavioral Sleep Medicine
Rebecca R Langdon, Herbert C Biggs, Bevan Rowland
BACKGROUND: Australia's mineral, resource and infrastructure sectors continues to expand as operations in rural and remote locations increasingly rely on fly-in, fly-out or drive-in, drive-out workforces in order to become economically competitive. The issues in effectively managing these workforces are becoming more apparent with reported high amounts of turnover and concerns for safety and performance. The issues presented include a range of physical, mental, psychosocial, safety and community challenges...
October 17, 2016: Work: a Journal of Prevention, Assessment, and Rehabilitation
Farrukh Jamal, Quazi S Haque, Sangram Singh
BACKGROUND: Diverse group of agro-chemicals are indiscriminately sprayed by the farmers for pest control to enhance crop yield. About 25 million agricultural workers in the developing world suffer from at least one episode of poisoning each year, mainly by anticholinesterase- like organophosphates (OPs). OBJECTIVE: The present study was aimed to establish the OP toxicity in 187 occupationally exposed pesticide sprayers of mango plantation in rural Malihabad, Lucknow, in terms of neuro-cognitive impairment, mental health status, clinical symptoms, diabetes, and hematological factors...
2016: Open Biochemistry Journal
Sandra E Reznik, Eliot L Gardner, Charles R Ashby
September 26, 2016: International Journal of Infectious Diseases: IJID
Zizheng Guo, Ruiya Chen, Kan Zhang, Yirun Pan, Jianhui Wu
The impairing effects of mental fatigue on visual sustained attention were assessed by event-related potentials (ERPs). Subjects performed a dual visual task, which includes a continuous tracking task (primary task) and a random signal detection task (secondary task), for 63 minutes nonstop in order to elicit ERPs. In this period, the data such as subjective levels of mental fatigue, behavioral performance measures, and electroencephalograms were recorded for each subject. Comparing data from the first interval (0-25 min) to that of the second, the following phenomena were observed: the subjective fatigue ratings increased with time, which indicates that performing the tasks leads to increase in mental fatigue levels; reaction times prolonged and accuracy rates decreased in the second interval, which indicates that subjects' sustained attention decreased...
2016: PloS One
Chieh Grace Lau, Wai Kwong Tang, Xiang Xin Liu, Hua Jun Liang, Yan Liang, Vincent Mok, Adrian Wong, Gabor S Ungvari, Mansur A Kutlubaev, Ka Sing Wong
OBJECTIVE: To examine the relationship between neuroticism and fatigue in Chinese stroke patients. DESIGN: Cross-sectional. SETTING: PARTICIPANTS: One hundred and ninety-one ischemic stroke survivors recruited from the above-mentioned acute stroke unit between May 2010 and September 2011. INTERVENTIONS: None. MAIN OUTCOME MEASURES: The personality trait of neuroticism was measured with the neuroticism subscale of the Chinese version of the NEO-five-factor Inventory (NEO-FFI)...
September 24, 2016: Archives of Physical Medicine and Rehabilitation
Sophie E Berthouze, Coralie Dumoulin, Eric Reynes
Among side effects, fatigue is the most common symptoms described by patients in a wide range of chronic diseases. Described as "being drained physically, but also mentally and emotionally," often seen as the most distressing symptom, fatigue interferes with daily life by impairing quality of life, functional capacity, self-perception and social participation; it is potentially debilitating and it is associated with significant morbidity. Yet it remains relatively unknown, me-considered mis-assessed and mis-treated, partly due to the still limited understanding of its pathophysiology, its complex assessment, the lack of effective treatments (no medicine against fatigue apart specific pathological conditions) and of training to its management...
September 2016: Annals of Physical and Rehabilitation Medicine
Anne-Sophie Dolez, Azahara Alcantara, Romain Mouny
The Montévrain clinic wants to be a medical center oriented towards autonomy and recovery of patient autonomy, reintegration within the family, as well as social and professional reintegration. After studying the care offer and the population base in Seine et Marne, we wanted to get involved in order to improve the capacity of patients treated for breast cancer, suffering deconditioning, with or without joint limitation and functional impairment, with or without a mental deterioration. We studied the recommendations of the "plan cancer III", researched the tertiary phase of cancer treatment and studied literature about evaluation of the physical and mental condition...
September 2016: Annals of Physical and Rehabilitation Medicine
L Rayner, A Simpson, F Matcham, S Shetty, O Lahoti, G Groom, M Hotopf
OBJECTIVE: This cross-sectional survey aimed to assess the prevalence of depression, anxiety, post-traumatic stress disorder (PTSD), and drug and alcohol dependence in a limb reconstruction population and examine associations with demographic and functional variables. METHODS: As part of routine clinical care, data were collected from 566 patients attending a tertiary referral centre for limb reconstruction between April 2012 and February 2016. Depression, anxiety, post-traumatic stress disorder (PTSD), and alcohol and drug dependence were measured using standardised self-report screening tools...
October 2016: Journal of Psychosomatic Research
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