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https://www.readbyqxmd.com/read/28643572/distinctive-barriers-to-antiretroviral-therapy-adherence-among-non-adherent-adolescents-living-with-hiv-in-botswana
#1
Elizabeth Yang, Seipone Mphele, Neo Moshashane, Boineelo Bula, Jennifer Chapman, Harriet Okatch, Ed Pettitt, Ontibile Tshume, Tafireyi Marukutira, Gabriel Anabwani, Elizabeth Lowenthal
Levels of adherence to HIV treatment are lower among adolescents compared with older and younger individuals receiving similar therapies. We purposely sampled the most and least adherent adolescents from a 300-adolescent longitudinal HIV treatment adherence study in Gaborone, Botswana. Multiple objective and subjective measures of adherence were available and study participants were selected based on sustained patterns of either excellent or poor adherence over a one-year period. Focus group discussions (FGD) and in-depth interviews (IDI) were conducted with the adolescents and a subset of their caregivers with the goal of revealing barriers and facilitators of adherence...
June 23, 2017: AIDS Care
https://www.readbyqxmd.com/read/28642125/safety-and-efficacy-of-dual-lead-thalamic-deep-brain-stimulation-for-patients-with-treatment-refractory-multiple-sclerosis-tremor-a-single-centre-randomised-single-blind-pilot-trial
#2
Seth F Oliveria, Ramon L Rodriguez, Dawn Bowers, Daniel Kantor, Justin D Hilliard, Erin H Monari, Bonnie M Scott, Michael S Okun, Kelly D Foote
BACKGROUND: Efficacy in previous studies of surgical treatments of refractory multiple sclerosis tremor using lesioning or deep brain stimulation (DBS) has been variable. The aim of this study was to investigate the safety and efficacy of dual-lead thalamic DBS (one targeting the ventralis intermedius-ventralis oralis posterior nucleus border [the VIM lead] and one targeting the ventralis oralis anterior-ventralis oralis posterior border [the VO lead]) for the treatment of multiple sclerosis tremor...
June 19, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28640972/understanding-adaptogenic-activity-specificity-of-the-pharmacological-action-of-adaptogens-and-other-phytochemicals
#3
REVIEW
Alexander Panossian
Adaptogens are stress-response modifiers that increase an organism's nonspecific resistance to stress by increasing its ability to adapt and survive. The classical reductionist model is insufficiently complex to explain the mechanistic aspects of the physiological notion of "adaptability" and the adaptogenic activity of adaptogens. Here, I demonstrate that (1) the mechanisms of action of adaptogens are impossible to rationally describe using the reductionist concept of pharmacology, whereas the network pharmacology approach is the most suitable method; and (2) the principles of systems biology and pharmacological networks appear to be more suitable for conceptualizing adaptogen function and are applicable to any phytochemical...
June 22, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28640076/efficacy-of-methylphenidate-for-the-treatment-of-mental-sequelae-after-traumatic-brain-injury
#4
Wei-Tao Zhang, Ya-Fei Wang
BACKGROUND: This study aimed to evaluate the effect of methylphenidate for treating mental sequelae after traumatic brain injury (TBI). METHODS: Thirty-six patients with TBI were randomly divided into the intervention group and placebo group. The participants in the intervention group received methylphenidate, while subjects in the placebo group were administered a placebo. This study was conducted from January 2014 to December 2016. The outcome measurements included Mental Fatigue Scale, Choice Reaction Time, Compensatory Tracking Task, Mental Arithmetic Test, Digit Symbol Substitution Test, Mini-Mental State Examination (MMSE), Beck Depression Inventory (BDI), and Hamilton Rating Scale for Depression...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28638612/assessment-of-physical-performance-and-quality-of-life-in-kidney-transplanted-patients-a-cross-sectional-study
#5
Pasquale Esposito, Francesco Furini, Teresa Rampino, Marilena Gregorini, Lucia Petrucci, Catherine Klersy, Antonio Dal Canton, Elena Dalla Toffola
BACKGROUND: Information on physical and mental wellness in renal transplantation is limited. Therefore, we performed a cross-sectional study to evaluate and describe the different components of physical performance and quality of life (QoL) in a cohort of kidney-transplanted patients. METHODS: Physical performance and QoL were determined through the administration of validated tests and questionnaires [muscle strength, dynamometer handgrip, tactile sensitivity, visual analogue scale (VAS) for pain, Timed Up and Go (TUG) test, Fatigue Severity Scale (FSS) and the 36-item Short Form Health Survey]...
February 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28637942/clinical-characteristics-and-psychotropic-prescribing-patterns-associated-with-impaired-concentration-in-asians-with-depressive-disorders-the-reap-ad-study
#6
Seon-Cheol Park, Min-Soo Lee, Sang Woo Hahn, Shigenobu Kanba, Mian-Yoon Chong, Kok Yoon Chee, Pichet Udomratn, Adarsh Tripathi, Norman Sartorius, Naotaka Shinfuku, Andi J Tanra, Yong Chon Park
The Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) study aimed to survey and review antidepressant prescribing patterns in different clinical settings in Asian countries/areas. The REAP-AD study collected comprehensive data for psychiatric patients prescribed antidepressants in 10 Asian countries/areas during the period from March to June 2013. Depressive disorders have been an important issue closely associated with ill-health and disability in the realm of mental health...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28627275/the-effects-of-exercise-on-patient-reported-outcomes-and-performance-based-physical-function-in-adults-with-acute-leukemia-undergoing-induction-therapy
#7
Ashley Leak Bryant, Allison M Deal, Claudio L Battaglini, Brett Phillips, Mackenzi Pergolotti, Erin Coffman, Matthew C Foster, William A Wood, Charlotte Bailey, Anthony C Hackney, Deborah K Mayer, Hyman B Muss, Bryce B Reeve
INTRODUCTION: Fatigue is a distressing symptom for adults with acute leukemia, often impeding their ability to exercise. OBJECTIVES: 1) Examine effects of a 4-week mixed-modality supervised exercise program (4 times a week, twice a day) on fatigue in adults with acute leukemia undergoing induction chemotherapy. 2) Evaluate effects of exercise program on cognition, anxiety, depression, and sleep disturbance. 3) Evaluate effect of intervention on adherence to exercise...
March 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28627013/regular-exercise-improves-the-well-being-of-parents-of-children-with-cancer
#8
Gail C Halliday, Gordon C P Miles, Julie A Marsh, Rishi S Kotecha, Angela J Alessandri
AIM: Parents of children with cancer describe impaired physical and social functioning, sleep disturbance and poor mental health. Exercise-related interventions impact positively on these quality of life domains, but have not been examined in this population. The aim of this longitudinal pilot study was to explore the feasibility of a 12-week pedometer-monitored walking intervention among parents of children with cancer, assessing adherence to a set activity target of 70,000 steps per week, and to explore the benefits of physical activity on mental and physical health...
June 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28620343/international-differences-in-multiple-sclerosis-health-outcomes-and-associated-factors-in-a-cross-sectional-survey
#9
Grace D Reilly, Awng Shar Mahkawnghta, Pia L Jelinek, Alysha M De Livera, Tracey J Weiland, Chelsea R Brown, Keryn L Taylor, Sandra L Neate, George A Jelinek, Claudia H Marck
Multiple sclerosis (MS) is a major cause of disability and poor quality of life (QOL). Previous studies have shown differences in MS health outcomes between countries. This study aimed to examine the associations between international regions and health outcomes in people with MS. Self-reported data were taken from the Health Outcomes and Lifestyle In a Sample of people with Multiple Sclerosis online survey collected in 2012. The 2,401 participants from 37 countries were categorized into three regions: Australasia, Europe, and North America...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28618891/musculoskeletal-manifestations-as-determinants-of-quality-of-life-impairment-in-patients-with-systemic-lupus-erythematosus
#10
M Piga, M Congia, A Gabba, F Figus, A Floris, A Mathieu, A Cauli
Objective The objective of this study was to identify determinants of health-related quality of life (HRQoL) impairment in patients with systemic lupus erythematosus (SLE). Methods Overall, 101 SLE patients were recruited; 37 healthy subjects and 35 rheumatoid arthritis (RA) patients served as controls. HRQoL was evaluated using three patient reported outcomes (PROs): the Short Form-36 version 2 (SF-36v2) health survey, the fatigue scale version 4 (FACITv4) and the Heath Assessment Questionnaire (HAQ). A large set of demographic and clinical variables, including SLE arthritis subtypes, was evaluated searching for factors independently associated with worse QoL...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28618733/pain-depression-levels-fatigue-sleep-quality-and-quality-of-life-in-elderly-patients-with-rheumatoid-arthritis
#11
İlknur Albayrak Gezer, Ayşe Balkarli, Beray Can, Sinan Bağçaci, Sami Küçükşen, Adem Küçük
BACKGROUND/AIM: The aim of this study was to evaluate and determine the relationships (if any) among pain, depression levels, fatigue, sleep quality, and quality of life in patients with rheumatoid arthritis (RA) aged 65 years and over, and to compare the results with those of RA patients under 65 years of age. MATERIALS AND METHODS: The study included 52 patients with RA aged 65 years and over (Group 1) and 84 patients with RA under 65 years of age (Group 2). Pain, depression levels, fatigue, sleep quality, quality of life, and disease activity of all of the participants were evaluated using a visual analog scale (VAS), the Beck Depression Inventory (BDI), the Checklist Individual Strength (CIS), the Pittsburgh Sleep Quality Index (PSQI), the Short Form-36 (SF-36), and the Disease Activity Score-28, respectively...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28617940/quality-of-life-in-childhood-epilepsy-in-pediatric-patients-enrolled-in-a-prospective-open-label-clinical-study-with-cannabidiol
#12
Evan C Rosenberg, Jay Louik, Erin Conway, Orrin Devinsky, Daniel Friedman
Recent clinical trials indicate that cannabidiol (CBD) may reduce seizure frequency in pediatric patients with certain forms of treatment-resistant epilepsy. Many of these patients experience significant impairments in quality of life (QOL) in physical, mental, and social dimensions of health. In this study, we measured the caregiver-reported Quality of Life in Childhood Epilepsy (QOLCE) in a subset of patients enrolled in a prospective, open-label clinical study of CBD. Results from caregivers of 48 patients indicated an 8...
June 15, 2017: Epilepsia
https://www.readbyqxmd.com/read/28611575/ica-derived-eeg-correlates-to-mental-fatigue-effort-and-workload-in-a-realistically-simulated-air-traffic-control-task
#13
Deepika Dasari, Guofa Shou, Lei Ding
Electroencephalograph (EEG) has been increasingly studied to identify distinct mental factors when persons perform cognitively demanding tasks. However, most of these studies examined EEG correlates at channel domain, which suffers the limitation that EEG signals are the mixture of multiple underlying neuronal sources due to the volume conduction effect. Moreover, few studies have been conducted in real-world tasks. To precisely probe EEG correlates with specific neural substrates to mental factors in real-world tasks, the present study examined EEG correlates to three mental factors, i...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28606771/inter-hemispheric-frontal-alpha-synchronization-of-event-related-potentials-reflects-memory-induced-mental-fatigue
#14
Xinyang Liu, Juntao Liu, Feng Duan, Rui Liu, Shuping Gai, Shengwei Xu, Jianhui Sun, Xinxia Cai
Mental fatigue is often associated with continuous brain activities in our daily life. It can diminish efficiency and increase errors. However, the related physiological features are still not clear and under exploration. The present study investigated changes of inter-hemispheric synchronization in event-related potentials (ERPs) due to mental fatigue during sustained memory processing. Twenty-six participants performed a continuous two-back memory task for around 2.5h. Prefrontal and frontal synchronies in the alpha frequency band (8-13Hz) were analyzed because of their close relationships with memory functions...
June 9, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28597308/randomized-controlled-trial-of-adding-telephone-follow-up-to-an-occupational-rehabilitation-program-to-increase-work-participation
#15
Karen Walseth Hara, Johan Håkon Bjørngaard, Søren Brage, Petter Christian Borchgrevink, Vidar Halsteinli, Tore Charles Stiles, Roar Johnsen, Astrid Woodhouse
Purpose Transfer from on-site rehabilitation to the participant's daily environment is considered a weak link in the rehabilitation chain. The main objective of this study is to see if adding boosted telephone follow-up directly after completing an occupational rehabilitation program effects work participation. Methods A randomized controlled study included participants with chronic pain, chronic fatigue or common mental disorders on long-term sick leave. After completing 3½ weeks of acceptance and commitment therapy based occupational rehabilitation, participants were randomized to boosted follow-up or a control group before returning to their daily environment...
June 9, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28588747/antifatigue-effect-of-luteolin-6-c-neohesperidoside-on-oxidative-stress-injury-induced-by-forced-swimming-of-rats-through-modulation-of-nrf2-are-signaling-pathways
#16
Fang-Fang Duan, Ying Guo, Jing-Wan Li, Ke Yuan
Luteolin-6-C-neohesperidoside (LN) is a flavonoid isolated from moso bamboo leaf. This study was performed to evaluate the antifatigue effect of LN on a rat model undergoing the weight-loaded forced swimming test (FST). Briefly, male Sprague-Dawley rats (20-22 weeks old) were forced to undertake exhaustive swimming every other day for 3 weeks. Each swimming session was followed by the administration of distilled water, LN (25-75 mg/kg), or ascorbic acid (100 mg/kg) 1 h later. Oral administration of LN significantly improved exercise endurance; normalized alterations in energy metabolic markers; and decreased serum lactic acid, lactate dehydrogenase, and blood urea nitrogen levels of rats that underwent FST...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28588427/evaluation-of-anti-fatigue-property-of-the-extruded-product-of-cereal-grains-mixed-with-cordyceps-militaris-on-mice
#17
Lei Zhong, Liyan Zhao, Fangmei Yang, Wenjian Yang, Yong Sun, Qiuhui Hu
BACKGROUND: Fatigue is a biological phenomenon that involves a feeling of extreme physical or mental tiredness that could potentially cause some severe chronic diseases. Recently, diet therapy has provided a new alternative to alleviate physical fatigue. In our previous study, addition of Cordyceps militaris (C. militaris) into an extruded product was shown to provide high nutrition and unique flavors; however, little is known whether this product has some scientific evidence regarding anti-fatigue property...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28583104/development-and-validation-of-a-claims-based-measure-as-an-indicator-for-disease-status-in-patients-with-multiple-sclerosis-treated-with-disease-modifying-drugs
#18
Michael Munsell, Molly Frean, Joseph Menzin, Amy L Phillips
BACKGROUND: Administrative healthcare claims data provide a mechanism for assessing and monitoring multiple sclerosis (MS) disease status across large, clinically representative "real-world" populations. The estimation of MS disease status using administrative claims can be a challenge, however, due to a lack of detailed clinical information. Retrospective claims analyses in MS have traditionally used rates of MS relapses to approximate disease status. Healthcare costs may be alternate, broader claims-based indicators of disease activity because costs reflect multiple facets of care of patients with MS, and there is a strong correlation between quality of life of patients with MS and costs of the disease...
June 5, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28582903/magnetic-stimulation-at-acupoints-relieves-mental-fatigue-an-event-related-potential-p300-study
#19
Shuo Yang, Yanyun Qiao, Lei Wang, Pengru Hao
BACKGROUND: Mental fatigue caused by continuous cognitive tasks represents one of the most worrying modern health problems. Event Related Potential (ERP) P300 is thought to be associated with cognitive function. OBJECTIVE: This study aimed at characterizing the neural activity correlated with the attentional processes and exploring a novelty method which combine the magnetic stimulation and acupoint to relieve mental fatigue caused by continuous cognitive tasks...
May 19, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28573820/aromatherapy-massage-versus-reflexology-on-female-elderly-with-acute-coronary-syndrome
#20
Tahereh Bahrami, Nahid Rejeh, Majideh Heravi-Karimooi, Mojtaba Vaismoradi, Seyed Davood Tadrisi, Christina L Sieloff
BACKGROUND: Fatigue and abnormalities in cardiovascular parameters are recognized as major problems for patients with acute coronary syndrome. Non-pharmacological nursing interventions are useful for controlling this fatigue and reducing patients' suffering during hospitalization. AIM: The present study compared the effects of aromatherapy massage and reflexology on fatigue and cardiovascular parameters in older female patients with acute coronary syndrome. DESIGN: This study was a randomized clinical trial...
June 2, 2017: Nursing in Critical Care
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