Yasuhiko Matsumoto, Kazuhisa Sekimizu
Silkworm, Bombyx mori, has various advantages as an experimental animal, such as low cost for rearing and a small ethical problem. Silkworm infection models with pathogenic bacteria have been established for identification of genes encoding virulence factors by a large-scale in vivo screening. In this review, we describe recent progress for the study of silkworm infection models for elucidating the mechanisms of fungi infection. The silkworm infection models have been established for Candida albicans, Candida tropicalis, Candida glabrata, and Cryptococcus neoformans, which are yeast type fungi, and Aspergillus fumigatus, Arthroderma vanbreuseghemii, Arthroderma benhamiae, Microsporum canis, Trichophyton rubrum, and Rhizopus oryzae, which are filamentous fungi...
January 21, 2019: Microbiology and Immunology