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https://www.readbyqxmd.com/read/29742446/quantification-of-m%C3%A3-llerian-inhibiting-substance-anti-m%C3%A3-llerian-hormone-polypeptide-by-isotope-dilution-mass-spectrometry
#1
Gail Whiting, Jackie Ferguson, Min Fang, David Pepin, Patricia Donahoe, Paul Matejtschuk, Chris Burns, Jun X Wheeler
Measurement of serum concentrations of Müllerian inhibiting substance (MIS), also known as anti-Müllerian Hormone (AMH) by immunoassay is gaining clinical acceptance and widespread use for the diagnosis of ovarian conditions and for prediction of the response to ovarian stimulation protocols as part of assisted reproductive therapies. Provision of an International Standard to harmonize immunoassay methods is required. It is desirable for the content of a future International Standard to be assigned in mass units for consistency with the units reported by current methods...
May 6, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29726668/-microdissection-testicular-sperm-extraction-for-patients-with-non-mosaic-klinefelter-s-syndrome-an-update
#2
REVIEW
Zhe Yu, Jun Yang, Ji-Hong Liu
Klinefelter's syndrome (KS) is a most frequent sex chromosomal disorder in males, which is characterized by hypogonadism and infertility. The development of assisted reproductive technology has made it possible for KS males to father children. Microdissection testicular sperm extraction (mTESE) is widely considered to be the best method for sperm retrieval in KS patients. This article presents an overview on mTESE for men with non-mosaic KS in the aspects of its predictors, sperm retrieval rate, operation procedure, preoperative hormonal therapy, and postoperative complications and testosterone reduction...
September 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29726663/-trigger-effect-of-hmg-and-hcg-in-the-treatment-of-unexplainable-non-obstructive-azoospermia
#3
Hao-Rui Hu, Hong-Chuan Nie, Wei-Min Yang, Yuan Sun, Hui Huang, Fang-Gang Xie
Objective: To investigate whether the trigger effect of human menopausal gonadotropins (hMG) and human chorionic gonadotropins (hCG) attributes to the treatment of unexplainable non-obstructive azoospermia (NOA). METHODS: We retrospectively analyzed the clinical data about 282 cases of unexplainable NOA treated in the Maternity and Child Health Hospital of Guizhou Province from January 2010 to May 2017. All the patients underwent trigger treatment by intramuscular injection of hMG at 75 IU 3 times a week for 2 weeks, followed by hCG at 2 000 IU twice a week for another 2 weeks, and meanwhile took vitamin E, Levocarnitine and Tamoxifen as an adjunctive therapy...
September 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29713542/systematic-review-of-antioxidant-types-and-doses-in-male-infertility-benefits-on-semen-parameters-advanced-sperm-function-assisted-reproduction-and-live-birth-rate
#4
Ahmad Majzoub, Ashok Agarwal
Objective: To explore the current evidence concerning the effect of oral antioxidant supplementation on various male fertility outcomes, as antioxidants are widely available compounds that are commonly used for the treatment of male infertility. Materials and methods: PubMed, Medline and Cochrane electronic databases were searched according to a modified Preferred Reporting Items for Systemic Reviews and Meta-Analyses (PRISMA) guidelines looking for studies investigating the effect of antioxidant therapy on infertile men...
March 2018: Arab Journal of Urology
https://www.readbyqxmd.com/read/29705659/effect-of-hcg-and-ovaprim%C3%A2-on-reproductive-characteristics-of-male-levantine-scraper-capoeta-damascina-valenciennes-1842
#5
Vahid Zadmajid, Somayeh Bashiri, Nastaran Sharafi, Ian Anthony Ernest Butts
Species richness and abundance within the genus Capoeta has been depleted. As such, there is great need for developing assisted reproductive technologies for controlling reproduction in captivity. Here, we conducted in vivo studies with single administrations of human chorionic gonadotropin (hCG) and Ovaprim™ [(D-Arg6 , Pro9 NEt)-sGnRH + domperidone] in wild-caught Levantine scraper, Capoeta damascina and then evaluated milt characteristics, fertilization success, serum sex steroids, and spermatogenesis via histological testicular development...
April 20, 2018: Theriogenology
https://www.readbyqxmd.com/read/29696942/challenges-of-fertility-preservation-in-leukemia-patients
#6
Moran Shapira, Hila Raanani, Sanaz Derech Chaim, Dror Meirow
An ongoing increase in survival rates among young leukemia patients is accompanied by a growing attention to possible long-term complications such as chemotherapy induced ovarian insufficiency and infertility. Therefore, an important element of the management of these patients is fertility preservation, which is challenged by considerations specific for leukemia. Such considerations include prepuberty, poor medical condition on presentation and the need for urgent chemotherapy, all of which may preclude the use of conventional assisted reproductive technologies...
April 24, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29670581/obesity-and-outcome-of-assisted-reproduction-in-patients-with-polycystic-ovary-syndrome
#7
REVIEW
Konstantinos Tziomalos, Konstantinos Dinas
Assisted reproduction, including in vitro fertilization and intracytoplasmic sperm injection, is increasingly being used for the management of infertility in patients with polycystic ovary syndrome (PCOS). However, there are limited data regarding the association between obesity and the outcome of assisted reproduction in this specific population as well as on the effects of weight loss. The aim of the present review is to summarize the existing evidence on the association between obesity and the outcome of assisted reproduction in patients with PCOS...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29602141/is-thromboprophylaxis-cost-effective-in-ovarian-hyperstimulation-syndrome-a-systematic-review-and-cost-analysis
#8
REVIEW
Kelly Comerford Wormer, Ayesha A Jangda, Farah A El Sayed, Katherine I Stewart, Sunni L Mumford, James H Segars
BACKGROUND: The majority of serious thromboembolic events occurring in assisted reproductive technologies (ART) are in women with ovarian hyperstimulation syndrome (OHSS). OBJECTIVES: The purpose of this study was to present a thorough review and cost analysis regarding the use of venous thromboembolism (VTE) prophylaxis in OHSS to inform clinical management. DATA SOURCES: Databases used were Pubmed and Embase, in addition to checking reference lists of retrieved articles (inception to November 2017)...
March 19, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29598846/the-role-of-mitochondrial-activity-in-female-fertility-and-assisted-reproductive-technologies-overview-and-current-insights
#9
REVIEW
Gustavo Nardini Cecchino, Emre Seli, Eduardo Leme Alves da Motta, Juan Antonio García-Velasco
Mitochondria have been implicated as key factors regulating female reproductive processes. Notable progress has been made in determining the role of mitochondria with respect to oocyte maturation, fertilization and early embryo development. In addition, mitochondrial function and dysfunction has been the subject of various studies in ovarian ageing and metabolic stress models. However, the overall mitochondrial impact on female fertility is yet to be uncovered. The mitochondrial DNA content of granulosa, cumulus and trophectoderm cells is being explored as a biomarker of oocyte quality and embryo viability...
March 8, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29583019/vaginal-progesterone-and-the-vaginal-first-pass-effect
#10
M P Warren
Vaginal progesterone is an effective alternative to systemic administration by oral or intramuscular use. The first-pass effect is reviewed, as are the most common uses for this route of delivery. This includes use in hormone replacement therapy, luteal support particularly in assisted reproduction, and avoidance of side-effects of oral progestins and progesterone. Vaginal progesterone represents a unique therapeutic solution to a number of clinical problems.
March 27, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29581237/female-fertility-preservation-past-present-and-future
#11
Benjamin Fisch, Ronit Abir
Anti-cancer therapy, particularly chemotherapy damages ovarian follicles and promotes ovarian failure. The only pharmacological means for protecting the ovaries from chemotherapy-induced injury is gonadotrophin-releasing hormone agonist, but its efficiency remains controversial; ovarian transposition is used to shield the ovary from radiation when indicated. Until the late 1990s, the only option for fertility preservation and restoration in women with cancer was embryo cryopreservation. The development of other assisted reproductive technologies such as mature oocyte cryopreservation and in vitro maturation of oocytes has contributed to fertility preservation...
March 26, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29564738/platelet-rich-plasma-therapy-and-reproductive-medicine
#12
EDITORIAL
Adriana Bos-Mikich, Ricardo de Oliveira, Nilo Frantz
Reports on clinical uses of platelet-rich plasma (PRP) have dramatically increased in the last decade. Indications for PRP therapy range from muscle and skeletal injuries to hair re-growth. More recently evidences have shown its positive effects in promoting endometrial and follicular growth and gestation in assisted reproduction cycles. We discuss the putative role of PRP on endometrial receptivity, with a brief history of its applications in research and clinical therapies. Despite its widespread uses in medicine, the mechanisms through which PRP exerts its regenerative effects are only postulated, not based on scientific data...
March 21, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29525298/severe-multiple-sclerosis-reactivation-after-gonadotropin-treatment
#13
Øivind Torkildsen, Trygve Holmøy, Kjell-Morten Myhr
Several reports indicate increased disease activity in patients with multiple sclerosis (MS) undergoing assisted reproductive techniques (ART), in the form of gonadtopin releasing hormone (GnRH) agonists. Other forms of ART treatments, like gonadotropin-treatment, have therefore been considered a safer option for MS-patients. We present a patient who despite being completely clinically and radiologically stable for eight years during disease modifying therapy experienced a nearly fulminant disease course almost immediately after starting gonadotropin-treatment, indicating that this form of follicle stimulating treatment could also be a major risk factor for MS disease activity...
March 6, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29521487/growth-hormone-deficiency-and-pregnancy-any-role-for-substitution
#14
Greisa Vila, Anton Luger
Growth hormone (GH) is not approved for use during conception and pregnancy. Nevertheless, data from the clinical care practice reveal that most women concieve on GH replacement therapy (GHRT), and more than half continue on GHRT also during pregnancy. GH stimulates the hypothalamic-pituitary-gonadal axis at all levels, and there is evidence that GH deficiency impacts the morphology of reproductive organs, onset of puberty, ovarian function and fertility. Patients with hypopituitarism often conceive using assisted reproductive techniques and several studies support the benefit of GH supplementation for achieving fertility in women with growth hormone deficiency...
March 8, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29462093/contraception-for-midlife-women-a-review
#15
Taniqua A Miller, Rebecca H Allen, Andrew M Kaunitz, Carrie A Cwiak
Family planning represents a key component of reproductive health care. Accordingly, the provision of contraception must span the reproductive age spectrum, including perimenopause. The risk of pregnancy is decreased, but not trivial, among women over 40 years of age. Evidence-based guidelines for contraceptive use can assist clinicians in counseling their patients in this population. Intrauterine contraception is one of the most effective methods and is safe to use in midlife women with few exceptions. Progestin-only contraception is another safe option for most midlife women because it is not associated with an increased risk of cardiovascular complications...
February 16, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29458889/pregnancy-following-robot-assisted-laparoscopic-partial-cystectomy-and-gonadotropin-releasing-hormone-agonist-treatment-within-three-months-in-an-infertile-woman-with-bladder-endometriosis
#16
Shun-Jen Tan, Chi-Huang Chen, Shauh-Der Yeh, Yun-Ho Lin, Chii-Ruey Tzeng
OBJECTIVE: To report an infertility case of deep-infiltrating bladder endometriosis conceiving following robot-assisted surgery and modified gonadotropin-releasing hormone agonist (GnRHa) treatment. CASE REPORT: A 33 year-old infertile female presenting with dysmenorrhea was found to have a bladder mass by pelvic ultrasound. Cystoscopy revealed a protruding tumor from the posterior bladder wall, and endometriosis was highly suspected. Robot-assisted laparoscopic partial cystectomy was performed for the deep-infiltrating bladder endometriosis...
February 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29422163/the-impact-of-complementary-therapies-on-psychosocial-factors-in-women-undergoing-in-vitro-fertilization-ivf-a-systematic-literature-review
#17
Jenna A LoGiudice, Jenna Massaro
AIM: This review evaluates the impact of complementary therapies on psychosocial factors in women undergoing IVF. BACKGROUND: According to the CDC, nearly 7% of married women in the United States face infertility. Approximately 1.5% of all infants born in the U.S. annually are conceived through assisted reproductive technologies (ART), such as IVF. Women undergoing ART report distress, anxiety, and depression related to their treatment. Stress has been cited as the top reason why women terminate treatment...
February 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29397924/dehydroepiandrosterone-enhances-decidualization-in-women-of-advanced-reproductive-age
#18
Douglas A Gibson, Ioannis Simitsidellis, Olympia Kelepouri, Hilary O D Critchley, Philippa T K Saunders
OBJECTIVE: To investigate the impact of the androgen precursor dehydroepiandrosterone (DHEA) on the decidualization of human endometrial stromal cells isolated from women of advanced reproductive age. DESIGN: In vitro study. SETTING: University research institute. PATIENT(S): Proliferative phase primary human endometrial stromal fibroblasts (hESFs) were isolated from women of advanced reproductive age (n = 16; mean age, 44...
April 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29379671/fertility-preservation-in-male-patients-subjected-to-chemotherapy-innovative-approaches-for-further-progress
#19
Mohamed Shehata
About 4% of male patients with cancer are under the age of 35 years. With the current increase in efficacy and safety of therapies, a growing number of young adults can achieve long-term survival. In male patients receiving systemic chemotherapy and or bone marrow transplantation, a permanent loss of fertility is a common adverse effect. The only possibility to preserve the patient's fertility is to spare the gametes or gamete-forming cells from the chemotherapeutic effect. In adults, this can be achieved by the cryopreservation of spermatozoa with the subsequent application of assisted reproductive technology...
December 2017: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29375149/smoking-decreases-endometrial-thickness-in-ivf-icsi-patients
#20
Anna Heger, Michael Sator, Katharina Walch, Detlef Pietrowski
Introduction: Smoking is a serious problem for the health care system. Many of the compounds identified in cigarette smoke have toxic effects on the fertility of both females and males. The purpose of this study was to determine whether smoking affects clinical factors during IVF/ICSI therapy in a single-center reproductive unit. Material and Methods: In a retrospective study of 200 IVF/ICSI cycles, endometrial thickness and the outcome of IVF/ICSI therapy were analyzed...
January 2018: Geburtshilfe und Frauenheilkunde
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