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https://www.readbyqxmd.com/read/28078226/clinical-utility-of-sperm-dna-fragmentation-testing-practice-recommendations-based-on-clinical-scenarios
#1
REVIEW
Ashok Agarwal, Ahmad Majzoub, Sandro C Esteves, Edmund Ko, Ranjith Ramasamy, Armand Zini
Sperm DNA fragmentation (SDF) has been generally acknowledged as a valuable tool for male fertility evaluation. While its detrimental implications on sperm function were extensively investigated, little is known about the actual indications for performing SDF analysis. This review delivers practice based recommendations on commonly encountered scenarios in the clinic. An illustrative description of the different SDF measurement techniques is presented. SDF testing is recommended in patients with clinical varicocele and borderline to normal semen parameters as it can better select varicocelectomy candidates...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28065695/perfusion-of-the-uterine-junctional-zone-in-nulliparous-and-primiparous-women-assessed-by-dce-mri-as-a-function-of-menstrual-cycle-and-hormonal-contraception
#2
L J Meylaerts, L Wijnen, M Bazot, M Grieten, W Ombelet, M Vandersteen
PURPOSE: To evaluate the perfusion parameters of inner and outer myometrium in healthy nulliparous and primiparous women who are and who are not currently using hormonal contraceptives by means of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). MATERIAL AND METHODS: We performed pelvic 1.5T DCE-MRI on 98 women: 18 nulliparous non-users, 30 nulliparous users, 12 primiparous non-users and 38 primiparous users of hormonal contraception (mean age respectively 26...
January 6, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28043345/effect-of-different-semen-extenders-for-the-storage-of-chilled-sperm-in-tigrina-leopardus-tigrinus
#3
D S R Angrimani, P M H Barros, J D A Losano, C N M Cortada, R P Bertolla, M A B V Guimarães, S H R Correa, V H Barnabe, M Nichi
To enhance the conservation of endangered populations, the present study aimed to evaluate whether Tigrinas (Leopardus tigrinus) sperm could be conserved under refrigeration for short periods while maintaining sufficient quality for use in assisted-reproductive techniques (i.e., cryopreservation, in vitro fertilization). For this purpose, semen samples from 15 Tigrinas individuals were submitted to conventional and functional tests after different cooling periods (4 °C; 0, 12, and 24 hours postcooling), using TCM 199 (TCM), Ham's F10 (HAM), Ham's F10 with bovine serum albumin (HBSA), and Tris-citrate egg yolk (TEYC) extenders...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/28018848/mitochondrial-transfer-implications-for-assisted-reproductive-technologies
#4
REVIEW
A S Reznichenko, C Huyser, M S Pepper
The use of mitochondrial transfer as a clinic procedure is drawing closer to reality. Here we provide a detailed overview of mitochondrial transfer techniques - both established and recent - including pronuclear, spindle, ooplasmic and blastomere transfer. Reasons as to why some techniques are more suitable for the prevention of mitochondrial DNA disease than others, as well as the advantages and disadvantages of each methodology, are discussed. The possible clinical introduction of these techniques has raised concerns about the adverse effects they may have on resultant embryos and offspring...
December 2016: Applied & Translational Genomics
https://www.readbyqxmd.com/read/28005934/obstetrical-complications-in-women-with-endometriosis-a-cohort-study-in-japan
#5
Takashi Harada, Fuminori Taniguchi, Kazunari Onishi, Youichi Kurozawa, Kunihiko Hayashi, Tasuku Harada
BACKGROUND: Endometriosis, which occurs in approximately 10% of women of reproductive age, is defined as the presence of endometrial tissue outside the uterus. Women with endometriosis are more likely to have difficulty conceiving and tend to receive infertility treatment, including assisted reproductive technology (ART) therapy. There has not yet been a prospective cohort study examining the effects of endometriosis on pregnancy outcome in pregnant Japanese women. METHODOLOGY: This was a prospective cohort study of the incidence of obstetrical complications in women with endometriosis using data of the Japan Environment & Children's Study (JECS)...
2016: PloS One
https://www.readbyqxmd.com/read/27990271/recent-advances-in-understanding-managing-male-infertility
#6
REVIEW
Jared M Bieniek, Kirk C Lo
Male infertility remains a struggle to definitively diagnose and treat with many men labelled as "idiopathic infertility" and eventually requiring assisted reproductive techniques.  Along those lines, research groups are continuing to explore current social and environmental factors, including the obesity epidemic, and their effects on male fertility potential.  Novel biomarkers of natural fertility status and azoospermia etiology have additionally seen recent attention with ACRV1 and TEX101/ECM1 assays either currently or soon to be commercially available...
2016: F1000Research
https://www.readbyqxmd.com/read/27916070/-effect-of-luteal-phase-gonadotropin-releasing-hormone-agonist-administration-on-pregnancy-outcome-in-ivf-icsi-cycles-a-systematic-review-and-meta-analysis
#7
L P Yu, N Liu, Y Liu
Objective: To evaluate the potential efficacy and safety of gonadotropin-releasing hormone agonist(GnRH-a) administration in the luteal-phase on in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles in assisted reproductive technology (ART). Methods: The relevant papers published before November 2015 were electronically searched in PubMed, EMBASE, Cochrane Library, WHO ICTRP, ClinicalTrials.gov, CNKI, CBM and WanFang database to collect randomized controlled trial (RCT) involving GnRH-a administration in the luteal-phase on IVF/ICSI cycles in ART...
November 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/27882769/-current-issues-of-reproductive-medicine-in-the-czech-republic
#8
P Ventruba, J Žáková, M Ješeta, D Rumpík, M Brandejská, I Crha, D Hlinka, L Jelínková, E Oráčová, J Pavelková, K Řežábek, K Veselá
INTRODUCTION: During the 25th symposium of assisted reproduction in Brno was lunch time organised as the lunch table discussion on the selected topics of assisted reproduction. More than 150 specialists reviewed themes related to gynecology and embryology.Discussed topics: Lunch table discussion covered the following topics: (1) Cross-border health care in assisted reproduction; (2) Indication for PGS (preimplantation genetic screening) in the context of actual information; (3) Does ovarian stimulation belong to the ambulance of registering gynecologists? (4) Therapy with clomifen - only for IVF specialists? (5) How and with whom should psychological support be directed during IVF? (6) Stimulation in women with low ovarian reserve; (7) Is basic semen analyses sufficient? (8) Time-lapse systems as relevant markers of embryonic development; (9) How to be oriented with choices of media and consumables in the IVF lab, and (10) "Freeze All" - is this new trend in cryopreservation suitable for all? CONCLUSIONS: Panel conclusions were presented during the afternoon session, which had great attendance, featured lively commentary, and produced some definitive consensus...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27821977/viral-hepatitis-and-assisted-reproduction
#9
EDITORIAL
Gautam N Allahbadia
Infertility treatment in couples where one or both parents are infected with hepatitis raises many concerns about transmission of the infection to the baby, laboratory technicians, and medical staff, and contamination of other gametes/embryos that are from virus-free parents in the same laboratory. Exposure to the other partner is only a risk when the couple's hepatitis status is discordant. The management of infertility, in association with HBV or HCV, has sparked debates about the potential risk of spread of infection to virus-free individuals, embryos, and/or semen...
December 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27807847/aspirin-for-in-vitro-fertilisation
#10
REVIEW
Charalampos S Siristatidis, George Basios, Vasilios Pergialiotis, Paraskevi Vogiatzi
BACKGROUND: Aspirin is used with the aim of optimising the chance of live birth in women undergoing assisted reproductive technology (ART), despite inconsistent evidence of its efficacy and safety (in terms of intraoperative bleeding during oocyte retrieval and risk of miscarriage). The most appropriate time to commence aspirin therapy and the length of treatment required are also still to be determined. This is the second update of the review first published in 2007. OBJECTIVES: To evaluate the effectiveness and safety of aspirin in women undergoing ART...
3, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27803586/the-role-of-indian-gynecologists-in-oncofertility-care-and-counselling
#11
Nalini Mahajan, Madhuri Patil, Surleen Kaur, Simrandeep Kaur, Padmaja Naidu
Oncofertility is gaining importance because of increasing cancer incidence, high survivorship, the need to provide a good quality of life to survivors and the desire of patients to preserve their fertility. Disseminating information about the effect of cancer and cancer treatment on fertility and the availability and effectiveness of fertility preservation techniques is critical. Gynaecologists in India act as family physicians and are in a unique position to guide cancer patients on issues of fertility and fertility preservation...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27800030/fertility-preservation-in-males-with-cancer-16-year-monocentric-experience-of-sperm-banking-and-post-thaw-reproductive-outcomes
#12
Raffaella Depalo, Doriana Falagario, Paola Masciandaro, Claudia Nardelli, Margherita Patrizia Vacca, Pasquale Capuano, Giorgina Specchia, Michele Battaglia
BACKGROUND: Anticancer treatments can impair male fertility. Cryopreservation of semen is an efficient procedure for fertility preservation. The aim of this study was to evaluate pre-freeze semen parameters among the various types of cancer, post-thaw sperm viability and reproductive outcome of samples used for assisted reproductive treatment (ART). METHODS: This study included 721 men with cancer that had their semen cryopreserved in our bank in 1999-2015. Semen analysis and cryopreservation were performed before the start of antineoplastic treatment, according to the World Health Organization recommendations, European Commission and Italian law...
November 2016: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/27795832/fertility-sparing-management-in-cervical-cancer-balancing-oncologic-outcomes-with-reproductive-success
#13
REVIEW
Karla Willows, Genevieve Lennox, Allan Covens
BACKGROUND: Cervical cancer is the fourth most common cancer among women worldwide, many of who are still within their reproductive lifespan. Advances in screening and treatment have increased the 5-year survival for early stage disease to over 90 % in developed countries. The focus is now shifting to reducing morbidity and improving fertility outcomes for cervical cancer patients. Radical trachelectomy with lymph node assessment became the standard of care for selected women with lesions <2 cm who desire fertility preservation...
2016: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/27651794/how-to-achieve-high-quality-oocytes-the-key-role-of-myo-inositol-and-melatonin
#14
REVIEW
Salvatore Giovanni Vitale, Paola Rossetti, Francesco Corrado, Agnese Maria Chiara Rapisarda, Sandro La Vignera, Rosita Angela Condorelli, Gaetano Valenti, Fabrizio Sapia, Antonio Simone Laganà, Massimo Buscema
Assisted reproductive technologies (ART) have experienced growing interest from infertile patients seeking to become pregnant. The quality of oocytes plays a pivotal role in determining ART outcomes. Although many authors have studied how supplementation therapy may affect this important parameter for both in vivo and in vitro models, data are not yet robust enough to support firm conclusions. Regarding this last point, in this review our objective has been to evaluate the state of the art regarding supplementation with melatonin and myo-inositol in order to improve oocyte quality during ART...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27631407/foetal-surgery-and-using-in-utero-therapies-to-reduce-the-degree-of-disability-after-birth-could-it-be-morally-defensible-or-even-morally-required
#15
Constantinos Kanaris
In 2008 the Human Fertilisation and Embryology Act amendments made deliberately choosing to bring disability into the world, using assisted reproduction, a criminal offence. This paper considers whether the legal prohibition above, should influence other policy areas concerning the welfare of future children such as new possibilities presented by foetal surgery and in utero gene therapy. If we have legal duties to avoid disability in one context should this influence our avoidance of disability in this other context? This paper investigates whether the State might have a stake in wider promotion of practices to reduce the degree of disability in foetuses that will come to exist (as opposed to those that will be aborted)...
September 8, 2016: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/27591233/corticosteroid-therapy-in-assisted-reproduction-immune-suppression-is-a-faulty-premise
#16
REVIEW
Sarah A Robertson, Min Jin, Danqing Yu, Lachlan M Moldenhauer, Michael J Davies, M Louise Hull, Robert J Norman
There is ongoing interest in immune-suppressant corticosteroid drugs such as prednisolone to treat infertility in women with repeated IVF failure and recurrent miscarriage. The rationale draws on the pervasive but flawed view that immune activation is inconsistent with normal pregnancy. This ignores clear evidence that controlled inflammation and activation of the immune response is essential for embryo implantation. Generally, the immune response actively promotes reproductive success - by facilitating endometrial receptivity and tolerance of the foreign embryo, and promoting vascular adaptation to support placental morphogenesis...
October 2016: Human Reproduction
https://www.readbyqxmd.com/read/27581117/economic-evaluation-of-three-frequently-used-gonadotrophins-in-assisted-reproduction-techniques-in-the-management-of-infertility-in-the-netherlands
#17
Vassilis Fragoulakis, Chris P Pescott, Jesper M J Smeenk, Evert J P van Santbrink, G Jur E Oosterhuis, Frank J M Broekmans, Nikos Maniadakis
BACKGROUND AND OBJECTIVE: Subfertility represents a multidimensional problem associated with significant distress and impaired social well-being. In the Netherlands, an estimated 50,000 couples visit their general practitioner and 30,000 couples seek medical specialist care for subfertility. We conducted an economic evaluation comparing recombinant human follicle-stimulating hormone (follitropin alfa, r-hFSH, Gonal-F(®)) with two classes of urinary gonadotrophins-highly purified human menopausal gonadotrophin (hp-HMG, Menopur(®)) and urinary follicle-stimulating hormone (uFSH, Fostimon(®))-for ovarian stimulation in women undergoing in vitro fertilization (IVF) treatment in the Netherlands...
December 2016: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/27574593/clinical-outcomes-of-varicocele-repair-in-infertile-men-a-review
#18
REVIEW
Koji Chiba, Masato Fujisawa
Varicoceles are a major cause of impaired spermatogenesis and the most common correctable cause of male infertility. They are found in approximately 40% of men with primary infertility and 80% of men with secondary infertility, although they also occur in 12% of men with normal semen parameters. The presence of a varicocele does not always affect spermatogenesis, as it has been reported that only 20% of men with documented varicoceles suffer fertility problems. However, varicocele repair appears to have beneficial effects in men with impaired semen parameters and palpable varicoceles...
August 2016: World Journal of Men's Health
https://www.readbyqxmd.com/read/27509657/-assisted-reproductive-technologies-and-ovarian-cancerogenesis
#19
REVIEW
T Totev, T Tihomirova, S Tomov, G Gorchev
Development of assisted reproductive technologies (ART) for treatment of infertility poses many questions about potential involvement of the drugs used in ART in the process of ovarian carcinogenesis. The presence of other etiological factors makes the assessment of risks implied by administering these drugs rather difficult. The results obtained in the study are controversial and inconclusive, yet theoretical and epidemiological data suggest that caution is needed in IVF patients, receiving such drug therapy...
2016: Akusherstvo i Ginekologii︠a︡
https://www.readbyqxmd.com/read/27469438/pregnancy-after-intracytoplasmic-sperm-injection-following-extended-sperm-preparation-and-hormone-therapy-in-an-azoospermic-man-with-maturation-arrest-and-microlithiasis-a-case-report-and-literature-review
#20
A-L Barbotin, C Ballot, J Sigala, M Leroy, J-M Rigot, D Dewailly, G Robin, V Mitchell
In the management of azoospermia, a combination of testicular sperm extraction and intracytoplasmic sperm injection (ICSI) is usually the most successful option for fatherhood. However, an outstanding question remains: How can at least a few spermatozoa be obtained from the ejaculate, thus avoiding the need for a surgical procedure? A 36-year-old man presented to Assisted Reproduction Unit with his 26-year-old wife. The ultrasound assessment revealed bilateral microlithiasis. Two spermograms revealed absolute azoospermia...
July 29, 2016: Andrologia
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