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Assistive reproductive therapy

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https://www.readbyqxmd.com/read/29135156/-isolated-teratozoospermia-is-there-a-role-for-antioxidant-therapy
#1
E A Efremov, E V Kasatonova, Ya I Melnik, A A Nikushina
Recently, literature has emerged that offers contradictory findings of idiopathic forms of isolated teratozoospermia that may confuse clinicians. Some researchers argue that at 0-1% of normal forms of spermatozoa, morphology itself cannot be a prognostic indicator of fertility, either in the planning of natural pregnancy, or when used in assisted reproduction. In this connection, the possible causes of teratozoospermia and alternative therapies are being actively sought, in addition to known invasive and costly procedures...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29135075/the-role-of-body-mind-and-environment-in-preterm-birth-mind-the-gap
#2
REVIEW
Shelby Yamamoto, Shahirose Premji
Preterm birth continues to be a problem affecting low-, middle-, and high-income countries, with rates increasing in some areas despite ongoing efforts to reduce the incidence. This emphasizes the need for more effective interventions, particularly if we aim to achieve the broad health targets of the Sustainable Development Goals (SDGs) by 2030. The current focus on medically-oriented interventions such as reducing nonmedically-indicated induction of labor, cesarean birth, and multiple embryo transfers associated with assisted reproductive technologies, as well as the application of cervical cerclage and use of progesterone therapy, though important, are likely only partial solutions to the complex phenomenon of preterm birth...
November 14, 2017: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/29129123/opinions-of-nurses-regarding-conscientious-objection
#3
Rafael Toro-Flores, Pilar Bravo-Agüi, María Victoria Catalán-Gómez, Marisa González-Hernando, María Jesús Guijarro-Cenisergue, Margarita Moreno-Vázquez, Isabel Roch-Hamelin, Tamara Raquel Velasco-Sanz
BACKGROUND: In the last decades, there have been important developments in the scientific and technological areas of healthcare. On certain occasions this provokes conflict between the patients' rights and the values of healthcare professionals which brings about, within this clinical relationship, the problem of conscientious objection. AIMS: To learn the opinions that the Nurses of the Madrid Autonomous Community have regarding conscientious objection. RESEARCH DESIGN: Cross-cutting descriptive study...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/29121416/pregnant-outcomes-of-atypical-polypoid-adenomyoma-treated-with-progestin-therapy
#4
Qin Chen, Weiguo Lu, Bingjian Lu
AIM: We aimed to investigate the long-term clinical and pregnancy outcome in patients with atypical polypoid adenomyoma (APA) after hysteroscopic excision. METHODS: We analyzed the clinicopathological features, including pregnancy outcomes, in 10 APA patients who had been treated with hysteroscopic excision of the lesion and progesterone therapy. RESULTS: The patients were all nulliparous, and nine had been clinically diagnosed as infertile...
November 9, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29121011/assisted-reproductive-technologies-to-prevent-human-mitochondrial-disease-transmission
#5
Andy Greenfield, Peter Braude, Frances Flinter, Robin Lovell-Badge, Caroline Ogilvie, Anthony C F Perry
Mitochondria are essential cytoplasmic organelles that generate energy (ATP) by oxidative phosphorylation and mediate key cellular processes such as apoptosis. They are maternally inherited and in humans contain a 16,569-base-pair circular genome (mtDNA) encoding 37 genes required for oxidative phosphorylation. Mutations in mtDNA cause a range of pathologies, commonly affecting energy-demanding tissues such as muscle and brain. Because mitochondrial diseases are incurable, attention has focused on limiting the inheritance of pathogenic mtDNA by mitochondrial replacement therapy (MRT)...
November 9, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/29071830/-hormonal-treatments-and-venous-thrombosis-in-women
#6
Justine Hugon-Rodin, Marc Blondon, Julie Bénard, Geneviève Plu-Bureau, Isabelle Streuli
Venous thromboembolism is frequently associated with hormonal factors in women. A thorough medical history taking of vascular risks and an individual evaluation of the risk-benefit ratio should precede any prescription of hormonal therapies. In contrary to progestin-only-pills, estroprogestative contraceptives increase 3-6 times the risk of venous thrombosis. In assisted reproductive techniques, venous thrombosis is frequently associated with the occurrence of a severe ovarian hyperstimulation syndrome. Antagonist ovarian stimulation protocols lower the risk of hyperstimulation and should therefore be preferred...
October 25, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29070478/-successful-pregnancy-following-intracytoplasmic-sperm-injection-embryo-transfer-in-a-patient-with-premature-ovarian-insufficiency-a-case-report
#7
Wei-Xu Ma, Xin Chen, Xing-Yu Zhou, Xue-Lan Li, Wan-le Chen, De-Sheng Ye, Shi-Ling Chen
We report a case of ovarian function fluctuation during long-term follow-up in a patient with premature ovarian insufficiency (POI). The patient finally obtained clinical pregnancy with subsequent uneventful full-term delivery after several intracytoplasmic sperm injection-embryo transfer (ICSI-ET) cycles. This case demonstrates that hormone replacement therapy (HRT) and assisted reproductive therapy should be applied as soon as possible to young patients with POI who have a strong desire for pregnancy in the absence of contraindications...
October 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29040334/advanced-maternal-age-and-adverse-pregnancy-outcomes-a-systematic-review-and-meta-analysis
#8
REVIEW
Samantha C Lean, Hayley Derricott, Rebecca L Jones, Alexander E P Heazell
BACKGROUND: Advanced maternal age (AMA; ≥35 years) is an increasing trend and is reported to be associated with various pregnancy complications. OBJECTIVE: To determine the risk of stillbirth and other adverse pregnancy outcomes in women of AMA. SEARCH STRATEGY: Embase, Medline (Ovid), Cochrane Database of Systematic Reviews, ClinicalTrials.gov, LILACS and conference proceedings were searched from ≥2000. SELECTION CRITERIA: Cohort and case-control studies reporting data on one or more co-primary outcomes (stillbirth or fetal growth restriction (FGR)) and/or secondary outcomes in mothers ≥35 years and <35 years...
2017: PloS One
https://www.readbyqxmd.com/read/29036809/role-of-fshr-rs6165-and-esr2-rs4986938-polymorphisms-in-ovarian-stimulation-of-iranian-women-who-underwent-assisted-reproduction-treatment
#9
Maryam Kaviani, Sayyed Mohammad Hossein Ghaderian, Soheila Arefi, Mehrdad Hashemi, Sarah Sadat Aghabozorg Afjeh
BACKGROUND: Gonadotropin therapy was used to stimulate the ovary in infertile women who underwent assisted reproduction treatment (ART). Numerous studies indicated that infertile women showed different responses to gonadotropin therapy. Follicle stimulating hormone receptor (FSHR) and Oestrogen receptor (ER) polymorphisms have been reported to involve induction of folliculogenesis and ovarian response to treatment. METHODS: In the present study, two polymorphisms, namely FSHR rs6165 and ESR2 rs4986938, were investigated in 198 Iranian infertile women aged less than 39 years who underwent ART...
September 29, 2017: Human Antibodies
https://www.readbyqxmd.com/read/29025060/adrenomedullin-improves-fertility-and-promotes-pinopodes-and-cell-junctions-in-the-peri-implantation-endometrium
#10
Brooke C Matson, Stephanie L Pierce, Scott T Espenschied, Eric Holle, Imani H Sweatt, Eric S Davis, Robert Tarran, Steven L Young, Trudy A Kohout, Marcel van Duin, Kathleen M Caron
Implantation is a complex event demanding contributions from both embryo and endometrium. Despite advances in assisted reproduction, endometrial receptivity defects persist as a barrier to successful implantation in women with infertility. We previously demonstrated that maternal haploinsufficiency for the endocrine peptide adrenomedullin (AM) in mice confers a subfertility phenotype characterized by defective uterine receptivity and sparse epithelial pinopode coverage. The strong link between AM and implantation suggested the compelling hypothesis that administration of AM prior to implantation may improve fertility, protect against pregnancy complications, and ultimately lead to better maternal and fetal outcomes...
September 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28978943/global-misregulation-of-genes-largely-uncoupled-to-dna-methylome-epimutations-characterizes-a-congenital-overgrowth-syndrome
#11
Zhiyuan Chen, Darren E Hagen, Tieming Ji, Christine G Elsik, Rocío M Rivera
Assisted reproductive therapies (ART) have become increasingly common worldwide and numerous retrospective studies have indicated that ART-conceived children are more likely to develop the overgrowth syndrome Beckwith-Wiedemann (BWS). In bovine, the use of ART can induce a similar overgrowth condition, which is referred to as large offspring syndrome (LOS). Both BWS and LOS involve misregulation of imprinted genes. However, it remains unknown whether molecular alterations at non-imprinted loci contribute to these syndromes...
October 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28961228/non-invasive-approaches-to-epigenetic-based-sperm-selection
#12
Miriama Štiavnická, Laura Abril-Parreño, Jan Nevoral, Milena Králíčková, Olga García-Álvarez
Since sperm size and form do not necessarily provide information on internal sperm structures, novel sperm markers need to be found in order to conduct assisted reproductive therapies (ART) successfully. Currently, the priority of andrologists is not only to select those sperm able to fertilize the oocyte, but also a high quality of sperm that will guarantee a healthy embryo. Evidence of this shows us the importance of studying sperm intensively on genetic and epigenetic levels, because these could probably be the cause of a percentage of infertility diagnosed as idiopathic...
September 29, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28959743/new-promising-strategies-in-oncofertility
#13
Janella N Hudson, Nathanael B Stanley, Leena Nahata, Meghan Bowman-Curci, Gwendolyn P Quinn
INTRODUCTION: Approximately 70,000 adolescent and young adults (AYA) are diagnosed with cancer each year. While advancements in treatment have led to improved prognosis and survival for patients, these same treatments can adversely affect AYA reproductive capacity. Localized treatments such as surgery and radiation therapy may affect fertility by removing or damaging reproductive organs, and systemic therapies such as chemotherapy can be toxic to gonads, (ovaries and testicles), thus affecting fertility and/or endocrine function...
2017: Expert Review of Quality of Life in Cancer Care
https://www.readbyqxmd.com/read/28950441/evaluation-of-sperm-dna-quality-in-men-presenting-with-testicular-cancer-and-lymphoma-using-alkaline-and-neutral-comet-assays
#14
K Kumar, S Lewis, S Vinci, A Riera-Escamilla, M-G Fino, L Tamburrino, M Muratori, P Larsen, C Krausz
Despite more cancers in young men over the past two decades, improvements in therapies give a greater chance to live full lives following treatment. Sperm genomic quality is variable following cancer diagnosis, so its assessment is important if sperm cryopreservation is being considered. Here, we evaluated DNA damage using two DNA damage assays: an alkaline and for the first time, a neutral Comet assays in men presenting with testicular cancer (n = 19 for alkaline and 13 for neutral group) and lymphoma (n = 13 for alkaline and 09 for neutral group) compared with fertile donors (n = 20 for alkaline and 14 for neutral group)...
September 26, 2017: Andrology
https://www.readbyqxmd.com/read/28948816/the-influence-of-smoking-and-cessation-on-the-human-reproductive-hormonal-balance
#15
H Jandíková, M Dušková, L Stárka
Smoking is the most widespread substance dependence in the world. Nicotine and some other components of the cigarette smoke cause various endocrine imbalances, and have negative effects on pituitary, thyroid, adrenal, testicular and ovarian functions. Here, we examined studies that describe the influence of smoking and smoking cessation on the male and female reproductive systems. We also focused on studies providing an account of differences in cessation success rates between men and women. In men, the most common effects associated with smoking are erectile dysfunction and decreasing spermiogram quality...
September 26, 2017: Physiological Research
https://www.readbyqxmd.com/read/28927307/biological-therapy-for-non-obstructive-azoospermia
#16
Sarah C Vij, Edmund Sabanegh, Ashok Agarwal
Most male patients with non-obstructive azoospermia (NOA) have no therapeutic options outside of assisted reproductive techniques to conceive a biological child. If mature sperm cannot be obtained from the testes, these patients must rely on options of donor sperm or adoption. Several techniques are in the experimental stage to provide this patient population alternatives for conceiving. Areas covered: This review discusses three of the experimental techniques for restoring fertility in men with NOA: spermatogonial stem cell transplantation, the use of adult and embryonic stem cells to develop mature gametes and gene therapy...
September 19, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28925272/-fertility-preserving-methods-in-women-with-breast-cancer-before-gonadotoxic-therapy
#17
N Halászová, I Crha, M Huser, V Weinberger, J Žáková, M Ješeta, E Lousová, E Filipinská, P Ventruba
OBJECTIVE: To present current options and own experiences with ovarian stimulation in young women with breast cancer before gonadotoxic therapy. DESIGN: Review article with own experiencies. METHODS: Literary search, analysis of own experiences with complex therapy in women with breast cancer planning pregnancy, definitions of stimulating protocols, using methods of assisted reproduction. SETTING: Department of Obstetrics and Gynecology, Faculty of Medicine, Masaryk University and University Hospital Brno...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28904798/patterns-of-residual-hiv-1-rna-shedding-in-the-seminal-plasma-of-patients-on-effective-antiretroviral-therapy
#18
Christophe Pasquier, Marie Walschaerts, Stéphanie Raymond, Nathalie Moinard, Karine Saune, Myriam Daudin, Jacques Izopet, Louis Bujan
BACKGROUND: More and more HIV-1-infected men on effective antiretroviral treatment (ART) have unprotected sex in order to procreate. The main factor influencing transmission is seminal HIV shedding. While the risk of HIV transmission is very low, it is difficult to assess in individuals. Nevertheless, it should be quantified. RESULTS: We retrospectively analysed seminal plasma HIV-1 shedding by 362 treated HIV-infected men attending a medically assisted reproduction centre (1998-2013) in order to determine its frequency, the impact of the antiretroviral regimen on HIV shedding, and to identify shedding patterns...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28898686/the-impact-of-ovulation-induction-and-ovarian-stimulation-on-the-risk-of-pregnancy-induced-hypertension-and-on-neonatal-outcomes-a-case-control-study
#19
Lionel Carbillon, Heloise Gronier, Isabelle Cedrin-Durnerin, Isabelle Pharisien, Minh T Nguyen, Paul Valensi, Emmanuel Cosson
OBJECTIVES: To study the role of ovarian stimulation procedures on the risk of pregnancy-induced hypertension, gestational diabetes mellitus and neonatal outcomes according to women's characteristics and the causes of infertility. DESIGN: Retrospective, observational, case/control study. PATIENTS: Spontaneous pregnancies (group A, n=8107), pregnancies achieved after mild ovarian ovulation induction without other Assisted Reproductive Technology (ART) procedures (group B, n=44), pregnancies after mild ovarian stimulation and ART procedures (group C, n=53) or pregnancies after multi (>2) follicular stimulation with gonadotrophin therapy and ART procedures (group D, n=133); all of the groups had identical protocols for prenatal care...
September 1, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28890430/how-to-personalize-ovarian-stimulation-in-clinical-practice
#20
Giovanna Sighinolfi, Valentina Grisendi, Antonio La Marca
Controlled ovarian stimulation (COS) in in vitro fertilization (IVF) cycles is the starting point from which couple's prognosis depends. Individualization in follicle-stimulating hormone (FSH) starting dose and protocol used is based on ovarian response prediction, which depends on ovarian reserve. Anti-Müllerian hormone levels and the antral follicle count are considered the most accurate and reliable markers of ovarian reserve. A literature search was performed for studies that addressed the ability of ovarian reserve markers to predict poor and high ovarian response in assisted reproductive technology cycles...
September 1, 2017: Journal of the Turkish German Gynecological Association
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