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https://www.readbyqxmd.com/read/28428944/the-status-of-assisted-reproductive-technology-in-korea-in-2012
#1
Gyoung Hoon Lee, Hyun Jin Song, Young Min Choi, Hyuck Dong Han
OBJECTIVE: This study was designed to report the status of assisted reproductive technology (ART) therapy in South Korea between January 1, 2012 and December 31, 2012. METHODS: A localized online survey, originally developed by the International Committee Monitoring Assisted Reproductive Technologies, was first launched and provided to all available ART centers via email in 2015. Fresh embryo transfer (FET) cases were categorized as standard in vitro fertilization, intracytoplasmic sperm injection (ICSI), or half-ICSI...
March 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28408620/oncofertility-fertile-ground-for-conflict-between-patient-autonomy-and-medical-values
#2
Sarah K Walsh, Elizabeth S Ginsburg, Lisa Soleymani Lehmann, Ann H Partridge
Oncofertility is a unique, multidisciplinary field that serves to bridge the gap between available fertility resources and the special reproductive needs of cancer patients. Oncofertility is a growing field due to the increasing number of survivors, development of new oncologic therapies, extension of duration of therapies, and development and refinement of reproductive therapies. While the technologies and demand for services expand, clinicians need to be appropriately prepared for dealing with various clinical scenarios that may require ethical deliberation...
April 13, 2017: Oncologist
https://www.readbyqxmd.com/read/28405864/g-csf-and-stem-cell-therapy-for-the-treatment-of-refractory-thin-lining-in-assisted-reproductive-technology
#3
REVIEW
Youssef Mouhayar, Fady I Sharara
PURPOSE: The study aims to describe two promising therapeutic options for resistant "thin" endometrium in fertility treatment: granulocyte colony-stimulating factor (G-CSF) and stem cell therapy. METHODS: A review of the scientific literature related to patients with thin endometrium undergoing fertility treatment. RESULTS: Sufficient endometrial growth is fundamental for embryo implantation. Whether idiopathic or resulting from an underlying pathology, a thin endometrium of <7 mm is associated with lower probability of pregnancy; however, no specific thickness excludes the occurrence of pregnancy...
April 12, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28391738/acupuncture-in-reproductive-medicine-the-motivations-of-infertile-women-to-participate-in-a-randomised-controlled-trial
#4
Sheryl L de Lacey, Elizabeth Sanderman, Caroline A Smith
INTRODUCTION: Randomised controlled trials are the gold standard in medical research and are challenging to conduct successfully since high numbers of participants are needed to produce robust results. Therefore, it is important to understand what motivates patients to participate in one, particularly in Reproductive Medicine where the conduct of RCTs is rare. Just as it is important to evaluate medical interventions, it is equally important that adjuvant therapies are properly assessed...
April 10, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28368791/-fertility-sparing-management-of-endometrial-cancer-and-atypical-hyperplasia
#5
C Gonthier, A Trefoux-Bourdet, D Luton, M Koskas
The fertility sparing management of endometrial cancer and atypical hyperplasia concern women in childbearing age with stage 1, grade 1, endometrioid adenocarcinoma confined to endometrium or atypical hyperplasia (simple or complex). These pathologies affecting more frequently postmenopausal women, the number of people involved is relatively low. The main risk factor is hyperestrogenism and these patients often present a history of infertility with a desire for pregnancy. The recommendations for this conservative management are scarce and unclear...
February 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28361508/delivering-safer-conception-services-to-hiv-serodiscordant-couples-in-kenya-perspectives-from-healthcare-providers-and-hiv-serodiscordant-couples
#6
Kenneth Ngure, Grace Kimemia, Kristin Dew, Njambi Njuguna, Nelly Mugo, Connie Celum, Jared M Baeten, Renee Heffron
INTRODUCTION: For HIV serodiscordant couples in resource-limited settings, pregnancy is common despite the risk of sexual and/or perinatal HIV transmission. Some safer conception strategies to reduce HIV transmission during pregnancy attempts are available but often not used for reasons including knowledge, accessibility, preference and others. We sought to understand Kenyan health providers' and HIV serodiscordant couples' perspectives and experiences with safer conception. METHODS: Between August 2015 and March 2016, we conducted key informant interviews (KIIs) with health providers from public and private HIV care and fertility clinics and in-depth interviews (IDIs) and focus group discussions (FGDs) with HIV serodiscordant couples participating in an open-label study of integrated pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) for HIV prevention (the Partners Demonstration Project)...
March 8, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28361502/achieving-pregnancy-safely-for-hiv-serodiscordant-couples-a-social-ecological-approach
#7
REVIEW
Haneefa T Saleem, Manjulaa Narasimhan, Julie A Denison, Caitlin E Kennedy
The recognition and fulfilment of the sexual and reproductive health and rights (SRHR) of all individuals and couples affected by HIV, including HIV-serodiscordant couples, requires intervention strategies aimed at achieving safe and healthy pregnancies and preventing undesired pregnancies. Reducing risk of horizontal and vertical transmission and addressing HIV-related infertility are key components of such interventions. In this commentary, we present challenges and opportunities for achieving safe pregnancies for serodiscordant couples through a social ecological lens...
March 8, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28361501/fertility-care-interventions-should-be-provided-as-the-first-line-options-for-hiv-serodiscordant-couples-who-desire-children-in-settings-with-affordable-access-to-care-regardless-of-their-fertility-status
#8
Lauren Zakarin Safier, Mark V Sauer
INTRODUCTION: With increasing life expectancy, couples with at least one partner afflicted with HIV are more commonly pursuing the opportunity to have biologic offspring. Currently, there are no universally accepted recommendations regarding first line reproductive treatments for HIV serodiscordant couples lacking a history of infertility. We strongly believe that fertility care intervention should be the first line treatment, when affordably accessible, over natural conception for HIV serodiscordant couples to achieve pregnancy in a safe and efficacious manner...
March 8, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28341055/obstetric-care-for-women-with-thalassemia
#9
REVIEW
Terence T Lao
Thalassemia is the commonest monogenic disease and manifests as severe anemia. It is increasingly encountered outside the Mediterranean region, Africa, Middle East, and Southeast Asia because of immigration. Pregnancy, previously uncommon in patients with homozygous β-thalassemia, is encountered increasingly because of improved management and assisted reproduction technology; however, preconceptional problems that include anemia, iron overload, cardiac dysfunction, thromboembolism, alloimmunization, infections, and endocrine and bone disorders, could influence maternal and obstetric outcome...
February 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28339338/fertility-treatments-among-female-cancer-survivors-giving-birth-a-finnish-register-based-study
#10
Johanna Melin, Laura Madanat-Harjuoja, Sirpa Heinävaara, Nea Malila, Mika Gissler, Aila Tiitinen
BACKGROUND: Long-term survival rates for most types of childhood cancers have improved dramatically over the past decades. However, because of advances in multimodality treatments, cancer survivors nowadays more often face long-term complications, including diminished gonadal and reproductive function. The aim of this study was to identify whether the use of fertility treatments among early onset (0-34 years) cancer survivors giving birth differed from that among siblings giving birth and to identify the subgroups of cancer survivors that were most likely to require fertility treatments...
March 24, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28333033/freeze-all-cycle-in-reproductive-medicine-current-perspectives
#11
Matheus Roque, Marcello Valle, Alessandra Kostolias, Marcos Sampaio, Selmo Geber
The freeze-all strategy has emerged as an alternative to fresh embryo transfer (ET) during in vitro fertilization (IVF) cycles. Although fresh ET is the norm during assisted reproductive therapies (ART), there are many concerns about the possible adverse effects of controlled ovarian stimulation (COS) over the endometrium. The supra-physiologic hormonal levels that occur during a conventional COS are associated with modifications in the peri-implantation endometrium, which may be related to a decrease in pregnancy rates and poorer obstetric and perinatal outcomes when comparing fresh to frozen-thawed embryo transfers...
February 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28322539/a-review-on-ovarian-hyperstimulation-syndrome-ohss-management-strategies
#12
Ashley M Eskew, Kenan R Omurtag
Ovarian hyperstimulation syndrome (OHSS) is one of the most frequent, serious and potentially lethal iatrogenic complications of controlled ovarian stimulation. Despite extensive research, the exact pathogenesis of this syndrome remains less clear, but there appears to be a relationship of increased vascular permeability mediated by HCG and other downstream mediators. Adequate experience with ovulation induction therapy and identifying patients with known risk factors are essential in preventing OHSS. As this is a completely iatrogenic disease numerous strategies have been investigated to help decrease the risk of OHSS and their effects on pregnancy and live birth rate...
March 21, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28299777/recurrent-vulvovaginal-candidiasis-a-review-of-guideline-recommendations
#13
REVIEW
Alexia Matheson, Danielle Mazza
BACKGROUND: Recurrent vulvovaginal candidiasis (VVC) is a difficult-to-manage condition that affects 5-8% of women of reproductive age. Current treatment regimes have high relapse rates, resulting in poor quality of life for the women affected. AIM: To compare the quality and content of current guidelines concerned with recurrent VVC and to develop a summary of recommendations to assist in the management of women with this condition. METHODS: Relevant clinical guidelines were identified through a search of several databases (MEDLINE, SCOPUS and The Cochrane Library) and relevant websites...
March 15, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28296254/short-term-fsh-treatment-and-sperm-maturation-a-prospective-study-in-idiopathic-infertile-men
#14
E Casamonti, S Vinci, E Serra, M G Fino, S Brilli, F Lotti, M Maggi, M E Coccia, G Forti, C Krausz
The standard FSH treatment is based on a 3 months period, after which both quantitative/qualitative improvement of sperm parameters and increased pregnancy rate were reported. In this prospective clinical trial, for the first time, we studied (i) Sperm hyaluronic acid binding capacity after highly purified FSH (hpFSH) treatment; (ii) the effect after short-term and standard treatment on this functional parameter. As secondary objective, we analyzed three SNPs on FSHβ and FSHR genes to define their potential predictive value for responsiveness...
March 15, 2017: Andrology
https://www.readbyqxmd.com/read/28277122/the-role-of-progesterone-therapy-in-early-pregnancy-from-physiological-role-to-therapeutic-utility
#15
Adam Czyzyk, Agnieszka Podfigurna, Andrea Riccardo Genazzani, Blazej Meczekalski
Progesterone is a steroid hormone of essential role in reproduction. In early pregnancy, it is responsible for preparation of endometrium for implantation process and maintenance of gestational sac in uterus, also by modulation of maternal immune system. Even though, several indices has been proposed as markers of endogenous progesterone synthesis (progesterone or luteinizing hormone measurements, endometrial biopsy), none has been proved to be reliable in detecting luteal phase defect. Currently, several pharmaceutical formulations are available, but in clinical setting the non-oral formulations seems to be effective in therapy...
February 28, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28271699/individualization-of-controlled-ovarian-stimulation-in-vitro-fertilization-using-ovarian-reserve-markers
#16
Valentina Grisendi, Antonio La Marca
INTRODUCTION: In assisted reproduction technologies (ART) the controlled ovarian stimulation (COS) therapy is the starting point from which a good oocytes retrieval depends. Treatment individualization is based on ovarian response prediction, which largely depends on a woman's ovarian reserve. Anti-Müllerian hormone (AMH) and antral follicle count (AFC) are considered the most accurate and reliable markers of ovarian reserve. EVIDENCE ACQUISITION: A literature search was carried out for studies that addressed the ability of AMH and AFC to predict poor and/or excessive ovarian response in IVF cycles...
June 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28271655/use-of-electroacupuncture-and-transcutaneous-electrical-acupoint-stimulation-in-reproductive-medicine-a-group-consensus
#17
Fan Qu, Rong Li, Wei Sun, Ge Lin, Rong Zhang, Jing Yang, Li Tian, Guo-Gang Xing, Hui Jiang, Fei Gong, Xiao-Yan Liang, Yan Meng, Jia-Yin Liu, Li-Ying Zhou, Shu-Yu Wang, Yan Wu, Yi-Jing He, Jia-Yu Ye, Song-Ping Han, Ji-Sheng Han
With the rapid development of assisted reproductive technology, various reproductive disorders have been effectively addressed. Acupuncture-like therapies, including electroacupuncture (EA) and transcutaneous electrical acupoint stimulation (TEAS), become more popular world-wide. Increasing evidence has demonstrated that EA and TEAS are effective in treating gynecological disorders, especially infertility. This present paper describes how to select acupoints for the treatment of infertility from the view of theories of traditional Chinese medicine and how to determine critical parameters of electric pulses of EA/TEAS based on results from animal and clinical studies...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28235465/ovarian-reserve-testing-a-user-s-guide
#18
REVIEW
Reshef Tal, David B Seifer
Ovarian reserve is a complex clinical phenomenon influenced by age, genetics, and environmental variables. Although it is challenging to predict the rate of an individual's ovarian reserve decline, clinicians are often asked for advice about fertility potential and/or recommendations regarding the pursuit of fertility treatment options. The purpose of this review is to summarize the state-of-the-art of ovarian reserve testing, providing a guide for the obstetrician/gynecologist generalist and reproductive endocrinologist...
February 21, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28223181/the-effect-of-salpingectomy-on-ovarian-function
#19
REVIEW
Alexander Kotlyar, Julian Gingold, Shirley Shue, Tommaso Falcone
OBJECTIVE: To review the literature concerning the effects of salpingectomy on ovarian function as assessed using measures of ovarian reserve and outcomes from in-vitro fertilization and spontaneous pregnancy cycles. BACKGROUND: Tubal surgery is performed for a variety of indications in gynecology. Salpingectomy is the most aggressive form of tubal surgery and may be performed for potential risk reduction for epithelial ovarian cancer, sterilization, ectopic pregnancy and as a method to enhance fertility in the setting of a hydrosalpinx...
February 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28216918/spontaneous-conception-in-40-year-old-infertile-woman-with-polycystic-ovaries-after-complete-reversal-of-endometrial-intraepithelial-neoplasia-a-case-report-with-review-of-literature
#20
Swati Verma, Umesh N Jindal
We report a case of polycystic ovary syndrome and prolonged infertility in which endometrial intraepithelial neoplasia was reversed with high dose progesterone therapy. Spontaneous conception after failure of assisted reproductive techniques highlights the role of endometrial receptivity.
October 2016: Journal of Human Reproductive Sciences
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