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https://www.readbyqxmd.com/read/28319164/modeling-the-potential-impact-on-the-us-blood-supply-of-transfusing-critically-ill-patients-with-fresher-stored-red-blood-cells
#1
Arianna Simonetti, Hussein Ezzeldin, Mikhail Menis, Stephen McKean, Hector Izurieta, Steven A Anderson, Richard A Forshee
BACKGROUND: Although some studies have suggested that transfusion recipients may have better medical outcomes if transfused with red blood cell units stored for a short time, the overall body of evidence shows mixed results. It is important to understand how using fresher stored red blood cell units for certain patient groups may affect blood availability. METHODS: Based on the Stock-and-Flow simulation model of the US blood supply developed by Simonetti et al. 2014, we evaluated a newly implemented allocation method of preferentially transfusing fresher stored red blood cell units to a subset of high-risk group of critically ill patients and its potential impact on supply...
2017: PloS One
https://www.readbyqxmd.com/read/28301932/the-degradation-of-fluorotelomer-based-polymers-contributes-to-the-global-occurrence-of-fluorotelomer-alcohol-and-perfluoroalkyl-carboxylates-a-combined-dynamic-substance-flow-and-environmental-fate-modelling-analysis
#2
Li Li, Jianguo Liu, Jianxin Hu, Frank Wania
Using coupled dynamic substance flow and environmental fate models, CiP-CAFE and BETR-Global, we investigated whether degradation of side-chain fluorotelomer-based polymers (FTPs), mostly in waste stocks (i.e., landfills and dumps), serves as a long-term source of fluorotelomer alcohols (FTOHs) and perfluoroalkyl carboxylates (PFCAs) to the global environment. The modelling results indicate that, in the wake of the worldwide transition from long-chain to short-chain products, in-use stocks of C8 FTPs will peak and decline afterwards while the in-use stocks of C6 FTPs and waste stocks of both FTPs will generally grow...
March 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28301506/measuring-complexity-in-brazilian-economic-crises
#3
Letícia P D Mortoza, José R C Piqueira
Capital flows are responsible for a strong influence on the foreign exchange rates and stock prices macroeconomic parameters. In volatile economies, capital flows can change due to several types of social, political and economic events, provoking oscillations on these parameters, which are recognized as economic crises. This work aims to investigate how these two macroeconomic variables are related with crisis events by using the traditional complex measures due to Lopez-Mancini-Calbet (LMC) and to Shiner-Davison-Landsberg (SDL), that can be applied to any temporal series...
2017: PloS One
https://www.readbyqxmd.com/read/28297602/use-storage-and-disposal-of-electronic-equipment-in-switzerland
#4
Esther Thiébaud, Lorenz M Hilty, Mathias Schluep, Martin Faulstich
Electronic devices contain important resources, including precious and critical raw materials. For an efficient management of these resources, it is important to know where the devices are located, how long they are used and when and how they are disposed of. In this article, we explore the past and current quantities of electronic devices in the in-use stock and storage stock in Switzerland and quantify the flows between the use, storage and disposal phase with dynamic material flow analysis (MFA). Devices included are mobile phones, desktop and laptop computers, monitors, cathode ray tube and flat panel display televisions, DVD players, and headphones...
March 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28292984/plaques-formed-by-mutagenized-viral-populations-have-elevated-coinfection-frequencies
#5
Elizabeth R Aguilera, Andrea K Erickson, Palmy R Jesudhasan, Christopher M Robinson, Julie K Pfeiffer
The plaque assay is a common technique used to measure virus concentrations and is based upon the principle that each plaque represents a single infectious unit. As such, the number of plaques is expected to correlate linearly with the virus dilution plated, and each plaque should be formed by a single founder virus. Here, we examined whether more than one virus can contribute to plaque formation. By using genetic and phenotypic assays with genetically marked polioviruses, we found that multiple parental viruses are present in 5 to 7% of plaques, even at an extremely low multiplicity of infection...
March 14, 2017: MBio
https://www.readbyqxmd.com/read/28288391/evidence-of-phenotypic-stability-after-transduction-of-fluorescent-proteins-in-two-human-tongue-cancer-cell-lines
#6
Wei-Xin Cai, Li-Wu Zheng, Hong-Zhang Huang, Roger A Zwahlen
OBJECTIVES: This study investigated the phenotypic stability and biological properties of two human tongue cancer cell lines after transduction of fluorescent proteins. DESIGN: The human tongue cancer cell lines UM1 and UM2 were cultured with GFP and RFP lentiviral particles stock for 72h. Cells with successful transduction of fluorescent proteins were selected in a medium containing G418 antibiotics for two weeks. The proliferation rates of parental and transduced cell lines were evaluated by their population doubling time (PDT)...
March 6, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28276090/the-content-and-meaning-of-administrative-work-a-qualitative-study-of-nursing-practices
#7
Lucie Michel, Mathias Waelli, Davina Allen, Etienne Minvielle
AIM: To investigate the content and meaning of nurses' administrative work. BACKGROUND: Nurses often report that administrative work keeps them away from bedside care. The content and meaning of this work remains insufficiently explored. DESIGN: Comparative case studies. METHOD: The investigation took place in 2014. It was based on 254 hours of observations and 27 interviews with nurses and staff in two contrasting units: intensive care and long term care...
March 9, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28252906/-what-nurses-see-occurrence-and-typology-of-wastes-in-medical-and-surgical-wards-a-cross-sectional-study
#8
Angelo Dante, Michela Marega, Adriana Peteani, Adriana Checchi, Loreto Lancia
AIM: To describe the occurrence and the typology of waste in the nurses clinical practice as well as the differences between the medical and surgical area. METHODS: A cross-sectional study was conducted in a north eastern Italian hospital. Data collection, conducted on 100 nurses in September 2015, was carried out using a semi-structured questionnaire consisting of 56 items and eight dimensions (Overproduction / Underutilisation, Wait, Stocks, Process, Inefficiency and Errors, Material Transport and Information Flows, Movements, Dispersion of Knowledge)...
October 2016: Professioni Infermieristiche
https://www.readbyqxmd.com/read/28250810/managing-cryptic-biodiversity-fine-scale-intralacustrine-speciation-along-a-benthic-gradient-in-alpine-whitefish-coregonus-spp
#9
Alan G Hudson, Baenz Lundsgaard-Hansen, Kay Lucek, Pascal Vonlanthen, Ole Seehausen
Whitefish (Coregonus spp.) are an important catch for many freshwater fisheries, particularly in Switzerland. In support of this, supplemental stocking of whitefish species is carried out, despite lacking complete knowledge of the extent, distribution and origin of whitefish diversity in these lakes, potentially threatening local endemics via artificial gene flow. Here, we investigate phenotypic and genetic differentiation among coexisting whitefish species spawning along a depth gradient in a subalpine Swiss lake to better delineate intralacustrine whitefish biodiversity...
March 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28247843/quantitative-analysis-of-aloins-and-aloin-emodin-in-aloe-vera-raw-materials-and-finished-products-using-high-performance-liquid-chromatography-single-laboratory-validation-first-action-2016-09
#10
David Kline, Vicha Ritruthai, Silva Babajanian, Quanyin Gao, Prashant Ingle, Peter Chang, Gary Swanson
A single-laboratory validation study is described for a method of quantitative analysis of aloins (aloins A and B) andaloe-emodin in aloe vera raw materials and finished products. This method used HPLC coupled with UV detection at 380 nm for the aloins and 430 nm for aloe-emodin. The advantage of this test method is that the target analytes are concentrated from the sample matrix (either liquid or solid form) using stepwise liquid-liquid extraction (water-ethyl acetate-methanol), followed by solvent evaporation and reconstitution...
February 28, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28237472/flow-stock-and-impact-assessment-of-refrigerants-in-the-japanese-household-air-conditioner-sector
#11
Mianqiang Xue, Naoya Kojima, Takashi Machimura, Akihiro Tokai
Refrigerants provide society with great benefits while have the potential to cause adverse effects on the environment and human health. The present study estimated time-dependent flows and stocks and assessed the effects of refrigerants (R-22, R-410a, and R-32) in household air conditioners in Japan. It was found that stock of R-22 and R-410a peaked at 49,147t in 2000 and 55,994t in 2017, respectively. The largest flow of R-22 and R-410a to waste phase occurred at 3417t/yr. in 2005 and 4011t/yr. in 2023, respectively...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28216806/regional-distribution-and-losses-of-end-of-life-steel-throughout-multiple-product-life-cycles-insights-from-the-global-multiregional-matrace-model
#12
Stefan Pauliuk, Yasushi Kondo, Shinichiro Nakamura, Kenichi Nakajima
Substantial amounts of post-consumer scrap are exported to other regions or lost during recovery and remelting, and both export and losses pose a constraint to desires for having regionally closed material cycles. To quantify the challenges and trade-offs associated with closed-loop metal recycling, we looked at the material cycles from the perspective of a single material unit and trace a unit of material through several product life cycles. Focusing on steel, we used current process parameters, loss rates, and trade patterns of the steel cycle to study how steel that was originally contained in high quality applications such as machinery or vehicles with stringent purity requirements gets subsequently distributed across different regions and product groups such as building and construction with less stringent purity requirements...
January 2017: Resources, Conservation, and Recycling
https://www.readbyqxmd.com/read/28214118/optimizing-peri-urban-ecosystems-pure-to-re-couple-urban-rural-symbiosis
#13
REVIEW
Yong-Guan Zhu, Brian J Reid, Andrew A Meharg, Steve A Banwart, Bo-Jie Fu
Globally, rapid urbanization, along with economic development, is dramatically changing the balance of biogeochemical cycles, impacting upon ecosystem services and impinging on United Nation global sustainability goals (inter alia: sustainable cities and communities; responsible consumption and production; good health and well-being; clean water and sanitation, and; to protect and conserve life on land and below water). A key feature of the urban ecosystems is that nutrient stocks, carbon (C), nitrogen (N) and phosphorus (P), are being enriched...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28196339/acoustic-measurement-and-morphological-features-of-organic-sediment-deposits-in-combined-sewer-networks
#14
Iacopo Carnacina, Frédérique Larrarte, Nicoletta Leonardi
The performance of sewer networks has important consequences from an environmental and social point of view. Poor functioning can result in flood risk and pollution at a large scale. Sediment deposits forming in sewer trunks might severely compromise the sewer line by affecting the flow field, reducing cross-sectional areas, and increasing roughness coefficients. In spite of numerous efforts, the morphological features of these depositional environments remain poorly understood. The interface between water and sediment remains inefficiently identified and the estimation of the stock of deposit is frequently inaccurate...
January 26, 2017: Water Research
https://www.readbyqxmd.com/read/28184238/a-carbon-balance-model-for-the-great-dismal-swamp-ecosystem
#15
Rachel Sleeter, Benjamin M Sleeter, Brianna Williams, Dianna Hogan, Todd Hawbaker, Zhiliang Zhu
BACKGROUND: Carbon storage potential has become an important consideration for land management and planning in the United States. The ability to assess ecosystem carbon balance can help land managers understand the benefits and tradeoffs between different management strategies. This paper demonstrates an application of the Land Use and Carbon Scenario Simulator (LUCAS) model developed for local-scale land management at the Great Dismal Swamp National Wildlife Refuge. We estimate the net ecosystem carbon balance by considering past ecosystem disturbances resulting from storm damage, fire, and land management actions including hydrologic inundation, vegetation clearing, and replanting...
December 2017: Carbon Balance and Management
https://www.readbyqxmd.com/read/28167761/global-socioeconomic-material-stocks-rise-23-fold-over-the-20th-century-and-require-half-of-annual-resource-use
#16
Fridolin Krausmann, Dominik Wiedenhofer, Christian Lauk, Willi Haas, Hiroki Tanikawa, Tomer Fishman, Alessio Miatto, Heinz Schandl, Helmut Haberl
Human-made material stocks accumulating in buildings, infrastructure, and machinery play a crucial but underappreciated role in shaping the use of material and energy resources. Building, maintaining, and in particular operating in-use stocks of materials require raw materials and energy. Material stocks create long-term path-dependencies because of their longevity. Fostering a transition toward environmentally sustainable patterns of resource use requires a more complete understanding of stock-flow relations...
February 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28163027/pharmacists-readiness-to-provide-naloxone-in-community-pharmacies-in-west-virginia
#17
J Douglas Thornton, Elizabeth Lyvers, Virginia Ginger G Scott, Nilanjana Dwibedi
OBJECTIVES: The objective of this study is to assess West Virginia pharmacists' stocking and dispensing practices of opioid-related medications and to identify the educational needs relating to providing naloxone in community pharmacies. DESIGN: A cross-sectional, anonymous, 49-item survey was created and validated to assess the educational needs of West Virginia community pharmacists. SETTING: West Virginia. PARTICIPANTS: The data collection instrument was administered to 266 pharmacists currently licensed in West Virginia at 6 continuing pharmacy education events throughout the state from March 1 to June 15, 2016...
March 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28157288/envisioning-nano-release-dynamics-in-a-changing-world-using-dynamic-probabilistic-modeling-to-assess-future-environmental-emissions-of-engineered-nanomaterials
#18
Tian Yin Sun, Denise M Mitrano, Nikolaus A Bornhöft, Martin Scheringer, Konrad Hungerbühler, Bernd Nowack
The need for an environmental risk assessment for engineered nanomaterials (ENM) necessitates the knowledge about their environmental emissions. Material flow models (MFA) have been used to provide predicted environmental emissions but most current nano-MFA models consider neither the rapid development of ENM production nor the fact that a large proportion of ENM are entering an in-use stock and are released from products over time (i.e., have a lag phase). Here we use dynamic probabilistic material flow modeling to predict scenarios of the future flows of four ENM (nano-TiO2, nano-ZnO, nano-Ag and CNT) to environmental compartments and to quantify their amounts in (temporary) sinks such as the in-use stock and ("final") environmental sinks such as soil and sediment...
February 16, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28130912/effects-on-human-heart-valve-immunogenicity-in-vitro-by-high-concentration-cryoprotectant-treatment
#19
Benjamin A Högerle, Maria Schneider, Katrin Sudrow, Naima Souidi, Meaghan Stolk, Isabella Werner, Anna Biermann, Kelvin G M Brockbank, Ulrich A Stock, Martina Seifert
Previously it was shown that cryopreservation using an ice-free cryopreservation method with the cryoprotectant formulation VS83 beneficially modulated immune reactions in vivo and in vitro when compared with conventionally frozen tissues. In this study, we assessed the impact of a VS83 post-treatment of previously conventionally frozen human tissue on responses of human immune cells in vitro. Tissue punches of treated and non-treated (control) aortic heart valve tissue (leaflets and associated aortic root) were co-cultured for 7 days with peripheral blood mononuclear cells or enriched CD14(+) monocytes...
January 28, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28115722/reconciling-fisheries-catch-and-ocean-productivity
#20
Charles A Stock, Jasmin G John, Ryan R Rykaczewski, Rebecca G Asch, William W L Cheung, John P Dunne, Kevin D Friedland, Vicky W Y Lam, Jorge L Sarmiento, Reg A Watson
Photosynthesis fuels marine food webs, yet differences in fish catch across globally distributed marine ecosystems far exceed differences in net primary production (NPP). We consider the hypothesis that ecosystem-level variations in pelagic and benthic energy flows from phytoplankton to fish, trophic transfer efficiencies, and fishing effort can quantitatively reconcile this contrast in an energetically consistent manner. To test this hypothesis, we enlist global fish catch data that include previously neglected contributions from small-scale fisheries, a synthesis of global fishing effort, and plankton food web energy flux estimates from a prototype high-resolution global earth system model (ESM)...
January 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
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