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https://www.readbyqxmd.com/read/29785137/andrographolide-potentiates-the-antitumor-effect-of-topotecan-in-acute-myeloid-leukemia-cells-through-an-intrinsic-apoptotic-pathway
#1
Mohammad Hassan Hodroj, Achraf Jardaly, Sarah Abi Raad, Annalise Zouein, Sandra Rizk
Background: Topotecan (TP) is an anticancer drug acting as topoisomerase I inhibitor that is used in the treatment of many types of cancers including leukemia, but it has significant side effects. Andrographolide, a compound extracted from Andrographis paniculata , was recently proven to inhibit the growth of cancer cells and can induce apoptosis. The aim of this study is to investigate the possible synergism between TP and andrographolide in acute myeloid cells in vitro. Materials and methods: U937 acute myeloid leukemic cells were cultured using Roswell Park Memorial Institute (RPMI) medium and then treated for 24 h with TP and andrographolide prepared through the dilution of dimethyl sulfoxide (DMSO) stocks with RPMI on the day of treatment...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29760881/upwelling-and-eddies-affect-connectivity-among-local-populations-of-the-goldeye-rockfish-sebastes-thompsoni-pisces-scorpaenoidei
#2
Hyo Jae Yu, Jin-Koo Kim
The goldeye rockfish, Sebastes thompsoni , commercial rockfish catch in the Northwest Pacific Ocean, may influence its population structure. To clarify the population genetic structure of Korean S. thompsoni and its degree of hybridization with the most close species, Sebastes joyneri , we analyzed a mitochondrial (mt) DNA control region and eleven polymorphic microsatellite (ms) loci. S. joyneri individuals were clearly distinguished from S. thompsoni by the mtDNA control region and ms loci results, with single interspecific hybridization between two species suggesting no impact on genetic structure of S...
May 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29759229/evaluation-of-polar-organic-chemical-integrative-and-hollow-fibre-samplers-for-the-determination-of-a-wide-variety-of-organic-polar-compounds-in-seawater
#3
Leire Mijangos, Haizea Ziarrusta, Ailette Prieto, Oihane Zugazua, Olatz Zuloaga, Maitane Olivares, Aresatz Usobiaga, Albrecht Paschke, Nestor Etxebarria
The calibration of two passive samplers for the determination of 20 emerging organic compounds in seawater is described in this work: i) a new version of polar organic chemical integrative sampler (POCIS) containing 100 mg of mixed-mode anion exchanger (Strata X-AW) and 100 mg of polymeric HLB (Plexa) sorbent materials and using a highly porous Nylon membrane (30-μm pore size) and ii) polyethersulfone (PES) hollow fibre. Among the studied contaminants, herbicides, hormones, life style products (stimulants and artificial sweeteners), industrial chemicals (corrosion inhibitor and fluorinated compounds), personal care products and several pharmaceuticals were included...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29756692/the-presence-of-elastic-compression-stockings-reduces-the-fluid-responsiveness-of-patients-in-the-operating-room
#4
Elie Zogheib, Julien Maizel, Nabil Cherradi, Ammar Benammar, Béatrice Labont, Abdel Hchikat, Michael Bernasinski, Faouzi Trojette, Michel Slama, Hervé Dupont
BACKGROUND: To investigate whether elastic compression stockings (ECS) can affect fluid responsiveness parameters before and during passive leg raising (PLR) maneuvers. METHODS: In the operating room (OR), we performed a prospective study including patients referred for cardiac surgery. Blood pressure (BP), ΔPP, heart rate (HR), central venous pressure (CVP), stroke volume (SV) and aortic blood flow (ABF) (by esophageal doppler) were measured according to four conditions: supine position without ECS (baseline 1), lower limbs raised to an angle of 45° (PLR 1), returned to the supine position with ECS (baseline 2), then a second PLR maneuver with ECS was performed (PLR 2)...
May 11, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29727753/towards-a-systematic-understanding-of-the-dynamic-fate-of-polychlorinated-biphenyls-in-indoor-urban-and-rural-environments
#5
Li Li, Jon A Arnot, Frank Wania
Indoor environments and urban areas are hubs of chemical stocks and emissions, which contaminate those indoor and urban areas as well as the surrounding rural areas. Here, we introduce a newly developed nested multimedia indoor-urban-rural chemical fate model, coupled with a substance flow analysis, aiming to provide an integrated and dynamic understanding of the mass distribution, concentrations, and major pathways of contaminants within and between indoor, urban and rural environments. The model is applied to simulate the emissions, transport and fate of polychlorinated biphenyl (PCB) congeners 28 and 153 in the Western Baltic drainage basin over time...
May 1, 2018: Environment International
https://www.readbyqxmd.com/read/29720079/phylogeography-of-aegean-green-toads-bufo-viridis-subgroup-continental-hybrid-swarm-vs-insular-diversification-with-discovery-of-a-new-island-endemic
#6
Christophe Dufresnes, Petros Lymberakis, Panagiotis Kornilios, Romain Savary, Nicolas Perrin, Matthias Stöck
BACKGROUND: Debated aspects in speciation research concern the amount of gene flow between incipient species under secondary contact and the modes by which post-zygotic isolation accumulates. Secondary contact zones of allopatric lineages, involving varying levels of divergence, provide natural settings for comparative studies, for which the Aegean (Eastern Mediterranean) geography offers unique scenarios. In Palearctic green toads (Bufo viridis subgroup or Bufotes), Plio-Pleistocene (~ 2...
May 2, 2018: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29697790/mental-health-interventions-during-ventricular-assist-device-therapy-a-scoping-review
#7
Katharina Tigges-Limmer, Yvonne Brocks, Yvonne Winkler, Scott Stock Gissendanner, Michiel Morshuis, Jan F Gummert
OBJECTIVES: Because of the high prevalence of psychological disorders among ventricular assist device patients, mental health support is consensually recommended. No study as yet has provided an overview of recommended and reported mental health interventions. This article presents the results of a scoping review on these questions. METHODS: We searched standard databases for relevant search criteria and found 4 consensus guidelines and 13 publications with original research mentioning mental health interventions for ventricular assist device patients...
April 25, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29696904/-dynamics-of-natural-capital-in-shenyang-based-on-improved-three-dimensional-ecological-footprint
#8
Hai Yan Liu, Quan Guo Cheng, Jian Bing Wei, Xiao Huang
Natural capital trends of Shenyang from 1995 to 2014 were analyzed using improved three-dimensional ecological footprint model. The results showed that, from 1995 to 2014, the ecological carrying capacity per capita of Shenyang fluctuated within a narrow range generally; the per capital ecological footprint, ecological deficit, footprint size and the footprint depth per capita increased along a wave-like curve. The changing rates of footprint size and depth tended to stabilize gradually. The way of natural capital utilization of cultivated land changed from capital flow in 2004 to capital stock, the capital stock replaced capital flow and became a source to meet the need of na-tural resources in the regional cultivated land, the use ratios of stock-flows increased gradually...
December 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29696653/river-flow-zooplankton-and-dominant-zooplanktivorous-fish-dynamics-in-a-warm-temperate-south-african-estuary
#9
N Mbandzi, R J Wasserman, S H P Deyzel, N G Vine, A K Whitfield
The possible links between river flow, zooplankton abundance and the responses of zooplanktivorous fishes to physico-chemical and food resource changes are assessed. To this end, the seasonal abundance, distribution and diet of the estuarine round-herring Gilchristella aestuaria and Cape silverside Atherina breviceps were studied in the Kariega Estuary. Spatio-temporal differences were determined for selected physico-chemical variables, zooplankton abundance and zooplanktivorous fish abundance and distribution...
April 26, 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29692077/-spatial-temporal-pattern-of-sustainable-intensification-of-agricultural-land-use-in-shandong-province-china
#10
Shan Dong Niu, Xiao Lyu, Yang Yang Shi
Under the theoretical framework of sustainable intensification of agricultural land-use (SIALU), We used material flow analysis (MFA) method to establish evaluation index system for SIALU by utilizing data in 2000, 2005, 2010 and 2015 to quantify the level of SIALU of 17 cities in Shandong Province, and analyzed the variation in input-output of resources factors of agricultural land, spatial distribution of resource productivity and environmental economic efficiency, in order to reveal spatial-temporal differentiation of SIALU...
February 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29692045/-the-latest-progress-in-ecosystem-service-flow-research-methods
#11
Jing Yao, Xing Yuan He, Wei Chen
Ecosystem service flow is the key point and difficulty of ecosystem services research, which is now at the initial stage and show a developing trend of quantity and spatialization. However, the term "ecosystem service flow" is ambiguous. In this paper, we presented two descriptions about the term, and two corresponding theories and methods: the transmission of a service from ecosystems to people and distributed ecosystem model, and the flow of benefits accruing to people as generated by stocks of ecosystem structure and grey/black box theory...
January 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29680525/is-reduced-freshwater-flow-in-tigris-euphrates-rivers-driving-fish-recruitment-changes-in-the-northwestern-arabian-gulf
#12
A Ben-Hasan, C Walters, V Christensen, M Al-Husaini, H Al-Foudari
Like fishing, natural regime shifts and human-induced environmental changes are often equally important factors in driving fish stock declines. In the Northwestern Arabian Gulf, many fish stocks are declining, raising questions about the reduction in the flow of Tigris-Euphrates rivers. Here we investigate the relationship between Tigris-Euphrates river flow and the estimated recruitment patterns from assessment models. We found a positive correlation between the estimated finfish recruitment trends and the flow of Tigris-Euphrates rivers...
April 2018: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29660877/probabilistic-modelling-and-uncertainty-analysis-of-flux-and-water-balance-changes-in-a-regional-aquifer-system-due-to-coal-seam-gas-development
#13
J Sreekanth, Tao Cui, Trevor Pickett, David Rassam, Mat Gilfedder, Damian Barrett
Large scale development of coal seam gas (CSG) is occurring in many sedimentary basins around the world including Australia, where commercial production of CSG has started in the Surat and Bowen basins. CSG development often involves extraction of large volumes of water that results in depressurising aquifers that overlie and/or underlie the coal seams thus perturbing their flow regimes. This can potentially impact regional aquifer systems that are used for many purposes such as irrigation, and stock and domestic water...
April 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29623200/results-of-catheter-directed-thrombolysis-for-acute-ilio-femoral-deep-venous-thrombosis-a-retrospective-cohort-study
#14
Christina P Madsen, Jerzy Gesla, Radu L Vijdea, Maria A Serifi, Johnny K Christensen, Kim Houlind
Background: Catheter-directed thrombolysis may prevent post-thrombotic syndrome in patients with ilio-femoral deep venous thrombosis. We performed a retrospective review of prospectively collected follow-up data to evaluate the results of catheter-directed thrombolysis at our institution. Method: Patients admitted for venous thrombolysis were included in the study and their files screened for information regarding results and technical aspects of treatment and patient status on follow-up...
January 2018: JRSM Cardiovascular Disease
https://www.readbyqxmd.com/read/29616548/urban-mining-of-e-waste-is-becoming-more-cost-effective-than-virgin-mining
#15
Xianlai Zeng, John A Mathews, Jinhui Li
Stocks of virgin-mined materials utilized in linear economic flows continue to present enormous challenges. E-waste is one of the fastest growing waste streams, and threatens to grow into a global problem of unmanageable proportions. An effective form of management of resource recycling and environmental improvement is available, in the form of extraction and purification of precious metals taken from waste streams, in a process known as urban mining. In this work, we demonstrate utilizing real cost data from e-waste processors in China that ingots of pure copper and gold could be recovered from e-waste streams at costs that are comparable to those encountered in virgin mining of ores...
April 4, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29614456/understanding-human-infectious-cryptosporidium-risk-in-drinking-water-supply-catchments
#16
Brooke Swaffer, Hayley Abbott, Brendon King, Leon van der Linden, Paul Monis
Treating drinking water appropriately depends, in part, on the robustness of source water quality risk assessments, however quantifying the proportion of infectious, human pathogenic Cryptosporidium oocysts remains a significant challenge. We analysed 962 source water samples across nine locations to profile the occurrence, rate and timing of infectious, human pathogenic Cryptosporidium in surface waters entering drinking water reservoirs during rainfall-runoff conditions. At the catchment level, average infectivity over the four-year study period reached 18%; however, most locations averaged <5%...
March 27, 2018: Water Research
https://www.readbyqxmd.com/read/29610363/titration-of-lentivirus-vectors
#17
Miguel Sena-Esteves, Guangping Gao
The titer of a lentivirus vector is often expressed in transducing units per milliliter. This is a functional titer that reflects the lentivirus' ability to transduce a particular cell line under specific conditions. Transduction of other cell lines is likely to be different and will require optimization. 293T cells are used for production of lentivirus stocks, and they can be easily transduced with vesicular stomatitis virus glycoprotein (VSV-G) pseudotyped lentivirus vectors. Consequently, this cell line is commonly used to determine the functional titer of lentivirus vector stocks produced with this envelope...
April 2, 2018: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/29593732/a-distinct-t-follicular-helper-cell-subset-infiltrates-the-brain-in-murine-neuropsychiatric-lupus
#18
Shweta Jain, Ariel Stock, Fernando Macian, Chaim Putterman
Neuropsychiatric symptoms in systemic lupus erythematosus (SLE) are not uncommon, yet the mechanisms underlying disease initiation and progression in the brain are incompletely understood. Although the role of T cells in other lupus target organs such as the kidney is well defined, which T cells contribute to the pathogenesis of neuropsychiatric SLE is not known. The present study was aimed at characterizing the CD4 T cell populations that are present in the choroid plexus (CP) of MRL/MpJ-fas lpr mice, the primary site of brain infiltration in this classic lupus mouse model which exhibits a prominent neurobehavioral phenotype...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29582660/on-the-occurrence-of-single-and-double-peaked-emission-profiles-of-synthetic-chemicals
#19
Li Li, Frank Wania
This work aims to elucidate the circumstances that can lead to two peaks in the temporal emission profile of synthetic chemicals. Using a simplified substance flow model, we explore how emission factors, product lifespan and degradation half-life in waste stock influence the (i) relative importance of emissions from three lifecycle stages (industrial processes, use phase and waste disposal), and (ii) the resulting composite emission profile. A double-peaked emission profile occurs if the lifespan of products containing the chemical is longer than half of its production period, and the gross emission factor from waste disposal exceeds that from the use phase...
March 27, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29566830/affordability-challenges-to-value-based-pricing-mass-diseases-orphan-diseases-and-cures
#20
Patricia M Danzon
OBJECTIVES: To analyze how value-based pricing (VBP), which grounds the price paid for pharmaceuticals in their value, can manage "affordability" challenges, defined as drugs that meet cost-effectiveness thresholds but are "unaffordable" within the short-run budget. METHODS: Three specific contexts are examined, drawing on recent experience. First, an effective new treatment for a chronic, progressive disease, such as hepatitis C, creates a budget spike that is transitory because initial prevalence is high, relative to current incidence...
March 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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