keyword
https://read.qxmd.com/read/38543531/killing-of-plasmodium-sporozoites-by-basic-amphipathic-%C3%AE-helical-fusion-peptides
#1
JOURNAL ARTICLE
Manuela C Aguirre-Botero, Eduardo Aliprandini, Anisha Gladston, Olga Pacios, Rafael Miyazawa Martins, Jean-Luc Poyet, Rogerio Amino
Membranolytic molecules constitute the first line of innate immune defense against pathogenic microorganisms. Plasmodium sporozoites are potentially exposed to these cytotoxic molecules in the hemolymph and salivary glands of mosquitoes, as well as in the skin, blood, and liver of the mammalian host. Here, we show that sporozoites are resistant to bacteriolytic concentration of cecropin B, a cationic amphipathic antimicrobial insect peptide. Intriguingly, anti-tumoral cell-penetrating peptides derived from the anti-apoptotic protein AAC11 killed P...
February 27, 2024: Microorganisms
https://read.qxmd.com/read/38536757/maintenance-of-persistent-transmission-of-a-plant-arbovirus-in-its-insect-vector-mediated-by-the-toll-dorsal-immune-pathway
#2
JOURNAL ARTICLE
Yu-Juan He, Gang Lu, Bo-Jie Xu, Qian-Zhuo Mao, Yu-Hua Qi, Gao-Yang Jiao, Hai-Tao Weng, Yan-Zhen Tian, Hai-Jian Huang, Chuan-Xi Zhang, Jian-Ping Chen, Jun-Min Li
Throughout evolution, arboviruses have developed various strategies to counteract the host's innate immune defenses to maintain persistent transmission. Recent studies have shown that, in addition to bacteria and fungi, the innate Toll-Dorsal immune system also plays an essential role in preventing viral infections in invertebrates. However, whether the classical Toll immune pathway is involved in maintaining the homeostatic process to ensure the persistent and propagative transmission of arboviruses in insect vectors remain unclear...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38535532/advances-in-the-immunology-of-the-host-parasite-interactions-in-african-trypanosomosis-including-single-cell-transcriptomics
#3
REVIEW
Boyoon Choi, Hien Thi Vu, Hai Thi Vu, Magdalena Radwanska, Stefan Magez
Trypanosomes are single-celled extracellular parasites that infect mammals, including humans and livestock, causing global public health concerns and economic losses. These parasites cycle between insect vectors, such as tsetse flies and vertebrate hosts, undergoing morphological, cellular, and biochemical changes. They have remarkable immune evasion mechanisms to escape the host's innate and adaptive immune responses, such as surface coat antigenic variation and the induction of the loss of specificity and memory of antibody responses, enabling the prolongation of infection...
February 20, 2024: Pathogens
https://read.qxmd.com/read/38532315/immune-system-modulation-virus-transmission-during-parasitism-identified-by-multi-species-transcriptomics-of-a-declining-insect-biocontrol-system
#4
JOURNAL ARTICLE
Sarah N Inwood, Thomas W R Harrop, Morgan W Shields, Stephen L Goldson, Peter K Dearden
BACKGROUND: The Argentine stem weevil (ASW, Listronotus bonariensis) is a significant pasture pest in Aotearoa New Zealand, primarily controlled by the parasitoid biocontrol agent Microctonus hyperodae. Despite providing effective control of ASW soon after release, M. hyperodae parasitism rates have since declined significantly, with ASW hypothesised to have evolved resistance to its biocontrol agent. While the parasitism arsenal of M. hyperodae has previously been investigated, revealing many venom components and an exogenous novel DNA virus Microctonus hyperodae filamentous virus (MhFV), the effects of said arsenal on gene expression in ASW during parasitism have not been examined...
March 26, 2024: BMC Genomics
https://read.qxmd.com/read/38517449/enhancement-of-an-entomopathogenic-fungal-virulence-against-the-seedcorn-maggot-delia-platura-by-suppressing-immune-responses-with-a-bacterial-culture-broth-of-photorhabdus-temperata-subsp-temperata
#5
JOURNAL ARTICLE
Eticha Abdisa, Hyunje Park, Jiyoon Kwon, Gahyeon Jin, Mojtaba Esmaeily, Yonggyun Kim
In Korea, there are two maggot species in the Delia genus that commonly infest the roots and stems of the Welsh onion, thus causing serious economic damage on the crop at the seedling stage. In this study, the seedcorn maggot (Delia platura) was detected in onion fields in two different localities in Korea. After overwintering, maggot infestations occurred throughout the entire growing seasons from transplantation to harvest, but their specific patterns of occurrence varied in the two localities examined. Entomopathogenic fungi induced significant virulence against the maggot larvae, in which a strain of Beauveria bassiana was effective, though it exhibited limited mortality in its insecticidal activity...
March 2024: Archives of Insect Biochemistry and Physiology
https://read.qxmd.com/read/38507262/relish-involved-in-immunity-and-larval-survival-in-the-willow-leaf-beetle-plagiodera-versicolora
#6
JOURNAL ARTICLE
Xiao-Long Liu, Qi Zhang, Xin Wang, Yi-Peng Liu, Long-Ji Ze, Hai-Nan Zhang, Min Lu
BACKGROUND: Insects mainly rely on innate immunity against pathogen infection. Plagiodera versicolora (Coleoptera: Chrysomelidae), is a worldwide leaf-eating forest pest in salicaceous trees. However, the mechanisms of the immunodeficiency pathway (IMD) are still poorly understood. RESULTS: In this study, we obtained a Relish gene from our transcriptome analysis. Subsequently, the tissue and instar expression profiles were performed by quantitative real-time PCR...
March 20, 2024: Pest Management Science
https://read.qxmd.com/read/38497256/innate-immunity-in-aedes-mosquitoes-from-pathogen-resistance-to-shaping-the-microbiota
#7
REVIEW
Bretta Hixson, Robin Chen, Nicolas Buchon
Discussions of host-microbe interactions in mosquito vectors are frequently dominated by a focus on the human pathogens they transmit (e.g. Plasmodium parasites and arboviruses). Underlying the interactions between a vector and its transmissible pathogens, however, is the physiology of an insect living and interacting with a world of bacteria and fungi including commensals, mutualists and primary and opportunistic pathogens. Here we review what is known about the bacteria and fungi associated with mosquitoes, with an emphasis on the members of the Aedes genus...
May 6, 2024: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://read.qxmd.com/read/38494144/insect-immune-resolution-with-epome-dihome-and-its-dysregulation-by-their-analogs-leading-to-pathogen-hypersensitivity
#8
JOURNAL ARTICLE
Md Tafim Hossain Hrithik, Niayesh Shahmohammadi, Gahyeon Jin, Dong-Hee Lee, Nalin Singh, Anders Vik, Bruce D Hammock, Yonggyun Kim
Upon immune challenge, recognition signals trigger insect immunity to remove the pathogens through cellular and humoral responses. Various immune mediators propagate the immune signals to nearby tissues, in which polyunsaturated fatty acid (PUFA) derivatives play crucial roles. However, little was known on how the insects terminate the activated immune responses after pathogen neutralization. Interestingly, C20 PUFA was detected at the early infection stage and later C18 PUFAs were induced in a lepidopteran insect, Spodoptera exigua...
March 15, 2024: Insect Biochemistry and Molecular Biology
https://read.qxmd.com/read/38467221/immunological-regulation-by-toll-1-and-sp%C3%A3-tzle-4-in-larval-density-dependent-prophylaxis-of-the-oriental-armyworm-mythimna-separata
#9
JOURNAL ARTICLE
Suwan Jiang, Jianqiang Bao, Yuxuan Chen, Zhonglin Liu, Rui Liu, Yunxia Cheng, Lei Zhang, Xingfu Jiang, Hailong Kong
High population density has been shown to alter insect prophylactic immunity. Toll-Spätzle pathway performs a key function in insect innate immune response. To determine the role of Toll and Spätzle, two main components of Toll-Spätzle pathway, in the density-dependent prophylaxis of Mythimna separata. We identified full-length cDNA encoding the Toll-1 and Spätzle-4 genes in M. separata (designed MsToll-1 and Ms Spätzle-4). Both MsToll-1 and MsSpätzle-4 were expressed throughout all developmental stages...
March 9, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38458665/a-potential-trade-off-between-offense-and-defense-in-honeybee-innate-immunity-reduced-phagocytosis-in-honeybee-hemocytes-correlates-with-a-protective-response-after-exposure-to-imidacloprid-and-amitraz
#10
JOURNAL ARTICLE
Dani Sukkar, Philippe Laval-Gilly, Ali Kanso, Sabine Azoury, Antoine Bonnefoy, Jairo Falla-Angel
Phagocytosis "offense" is a crucial process to protect the organism from diseases and the effects of foreign particles. Insects rely on the innate immune system and thus any hindrance to phagocytosis may greatly affect their resistance to diseases and response to pathogens. The European honeybee, a valuable species due to its economic and environmental contribution, is being challenged by colony collapse disorder leading to its decline. Exposure to multiple factors including pesticides like imidacloprid and amitraz may negatively alter their immune response and ultimately make them more susceptible to diseases...
February 2024: Pesticide Biochemistry and Physiology
https://read.qxmd.com/read/38453114/silencing-gram-negative-bacteria-binding-protein-1-decreases-the-immunity-of-tribolium-castaneum-against-bacteria
#11
JOURNAL ARTICLE
Jingxiu Bi, Pingxiang Liu, Rui Gao, Yuying Jiang, Chao Zhang, Tong Zhao, Lei Gao, Yutao Wang
Gram-negative bacteria binding proteins (GNBPs) have the ability to recognize molecular patterns associated with microbial pathogens (PAMPs), leading to the activation of immune responses downstream. In the genome of Tribolium castaneum, three GNBP genes have been identified; however, their immunological roles remain unexplored. In our study, a GNBP1, designated as TcGNBP1, were identified from the cDNA library of T. castaneum. The coding sequence of TcGNBP1 consisted of 1137 bps and resulted in the synthesis of a protein comprising 378 amino acids...
March 5, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38443305/insects-essential-role-in-understanding-and-broadening-animal-medication
#12
REVIEW
Silvio Erler, Sheena C Cotter, Dalial Freitak, Hauke Koch, Evan C Palmer-Young, Jacobus C de Roode, Angela M Smilanich, H Michael G Lattorff
Like humans, animals use plants and other materials as medication against parasites. Recent decades have shown that the study of insects can greatly advance our understanding of medication behaviors. The ease of rearing insects under laboratory conditions has enabled controlled experiments to test critical hypotheses, while their spectrum of reproductive strategies and living arrangements - ranging from solitary to eusocial communities - has revealed that medication behaviors can evolve to maximize inclusive fitness through both direct and indirect fitness benefits...
March 4, 2024: Trends in Parasitology
https://read.qxmd.com/read/38420120/insights-into-midgut-cell-types-and-their-crucial-role-in-antiviral-immunity-in-the-lepidopteran-model-bombyx-mori
#13
REVIEW
Mian Muhammad Awais, Shigang Fei, Junming Xia, Min Feng, Jingchen Sun
The midgut, a vital component of the digestive system in arthropods, serves as an interface between ingested food and the insect's physiology, playing a pivotal role in nutrient absorption and immune defense mechanisms. Distinct cell types, including columnar, enteroendocrine, goblet and regenerative cells, comprise the midgut in insects and contribute to its robust immune response. Enterocytes/columnar cells, the primary absorptive cells, facilitate the immune response through enzyme secretions, while regenerative cells play a crucial role in maintaining midgut integrity by continuously replenishing damaged cells and maintaining the continuity of the immune defense...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38415382/research-progress-of-aphid-immunity-system-potential-effective-target-for-green-pest-management
#14
REVIEW
Li-Na Sun, Jian-Yu Meng, Zeng Wang, Shi-Yang Lin, Jie Shen, Shuo Yan
Due to the absence of acquired immunity, insects primarily rely on their innate immune system to resist pathogenic microorganisms and parasitoids in natural habitats. This innate immune system can be classified into cellular immunity and humoral immunity. Cellular immunity is mediated by hemocytes, which perform phagocytosis, aggregation, and encapsulation to fight against invaders, whereas the humoral immunity primarily activates the immune signaling pathways and induces the generation of immune effectors...
February 28, 2024: Insect Science
https://read.qxmd.com/read/38409870/bmpgpr-l4-is-a-negative-regulator-of-the-humoral-immune-response-in-the-silkworm-bombyx-mori
#15
JOURNAL ARTICLE
Weiyi Yang, Yongyi Lin, Yanying He, Qi Li, Weijian Chen, Qingsha Lin, Luc Swevers, Jisheng Liu
Toll, immune deficiency and prophenoloxidase cascade represent vital immune signaling pathways in insects. Peptidoglycan recognition proteins (PGRPs) are innate immune receptors that activate and regulate the immune signaling pathways. Previously, we reported that BmPGPR-L4 was induced in the silkworm Bombyx mori larvae by bacteria and peptidoglycan challenges. Here, we focused on the function of BmPGRP-L4 in regulating the expression of antimicrobial peptides (AMPs). The hemolymph from BmPGRP-L4-silenced larvae exhibited an enhanced inhibitory effect on the growth of Escherichia coli, either by growth curve or inhibitory zone experiments...
February 2024: Archives of Insect Biochemistry and Physiology
https://read.qxmd.com/read/38400018/the-role-of-noncoding-rna-in-the-transmission-and-pathogenicity-of-flaviviruses
#16
REVIEW
Xianwen Zhang, Yuhan Li, Yingyi Cao, Ying Wu, Gong Cheng
Noncoding RNAs (ncRNAs) constitute a class of RNA molecules that lack protein-coding capacity. ncRNAs frequently modulate gene expression through specific interactions with target proteins or messenger RNAs, thereby playing integral roles in a wide array of cellular processes. The Flavivirus genus comprises several significant members, such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV), which have caused global outbreaks, resulting in high morbidity and mortality in human populations...
February 2, 2024: Viruses
https://read.qxmd.com/read/38399416/immunomodulatory-peptides-as-vaccine-adjuvants-and-antimicrobial-agents
#17
JOURNAL ARTICLE
Shiva Hemmati, Zahra Saeidikia, Hassan Seradj, Abdolali Mohagheghzadeh
The underdevelopment of adjuvant discovery and diversity, compared to core vaccine technology, is evident. On the other hand, antibiotic resistance is on the list of the top ten threats to global health. Immunomodulatory peptides that target a pathogen and modulate the immune system simultaneously are promising for the development of preventive and therapeutic molecules. Since investigating innate immunity in insects has led to prominent achievements in human immunology, such as toll-like receptor (TLR) discovery, we used the capacity of the immunomodulatory peptides of arthropods with concomitant antimicrobial or antitumor activity...
February 2, 2024: Pharmaceuticals
https://read.qxmd.com/read/38387449/single-nucleus-sequencing-of-silkworm-larval-brain-reveals-the-key-role-of-lysozyme-in-the-antiviral-immune-response-in-brain-hemocytes
#18
JOURNAL ARTICLE
Min Feng, Shigang Fei, Jinglei Zou, Junming Xia, Wenxuan Lai, Yigui Huang, Luc Swevers, Jingchen Sun
The brain is considered as an immune-privileged organ, yet innate immune reactions can occur in the central nervous system of vertebrates and invertebrates. Silkworm (Bombyx mori) is an economically important insect and a lepidopteran model species. The diversity of cell types in the silkworm brain, and how these cell subsets produce an immune response to virus infection, remains largely unknown. We used single-nucleus RNA sequencing (snRNA-seq) to identify 19 distinct clusters representing Kenyon cell, glial cell, olfactory projection neuron, optic lobes neuron, hemocyte-like cell, and muscle cell types in the B...
February 22, 2024: Journal of Innate Immunity
https://read.qxmd.com/read/38368353/response-of-the-mosquito-immune-system-and-symbiotic-bacteria-to-pathogen-infection
#19
REVIEW
Manjin Li, Yang Zhou, Jin Cheng, Yiqing Wang, Cejie Lan, Yuan Shen
Mosquitoes are the deadliest animal in the word, transmitting a variety of insect-borne infectious diseases, such as malaria, dengue fever, yellow fever, and Zika, causing more deaths than any other vector-borne pathogen. Moreover, in the absence of effective drugs and vaccines to prevent and treat insect-borne diseases, mosquito control is particularly important as the primary measure. In recent decades, due to the gradual increase in mosquito resistance, increasing attention has fallen on the mechanisms and effects associated with pathogen infection...
February 17, 2024: Parasites & Vectors
https://read.qxmd.com/read/38366252/positive-selection-has-shaped-the-evolution-of-argentine-ant-immune-genes-both-in-native-and-introduced-supercolonies
#20
JOURNAL ARTICLE
Ida Holmberg, Lassi Tolonen, Jenni Paviala, Jes Søe Pedersen, Heikki Helanterä, Lumi Viljakainen
The highly invasive Argentine ant (Linepithema humile) started its colonisation from the species' native range in South America approximately 150 years ago and has since become one of the major pests in the world. We investigated how the shifts into new ranges have affected the evolution of Argentine ants' immune genes. To the best of our knowledge, this is the first broadscale population genetic study focusing on ants' immune genes. We analysed comprehensive targeted-seq data of immune and non-immune genes containing 174 genes from 18 Argentine ant supercolonies covering the species' native and introduced ranges...
February 14, 2024: Journal of Evolutionary Biology
keyword
keyword
52968
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.