Sydney Stanley, Caitlin N Spaulding, Qingyun Liu, Michael R Chase, Dang Thi Minh Ha, Phan Vuong Khac Thai, Nguyen Huu Lan, Do Dang Anh Thu, Nguyen Le Quang, Jessica Brown, Nathan D Hicks, Xin Wang, Maximillian Marin, Nicole C Howard, Andrew J Vickers, Wiktor M Karpinski, Michael C Chao, Maha R Farhat, Maxine Caws, Sarah J Dunstan, Nguyen Thuy Thuong Thuong, Sarah M Fortune
BACKGROUND: Bacterial diversity could contribute to the diversity of tuberculosis infection and treatment outcomes observed clinically, but the biological basis of this association is poorly understood. The aim of this study was to identify associations between phenogenomic variation in Mycobacterium tuberculosis and tuberculosis clinical features. METHODS: We developed a high-throughput platform to define phenotype-genotype relationships in M tuberculosis clinical isolates, which we tested on a set of 158 drug-sensitive M tuberculosis strains sampled from a large tuberculosis clinical study in Ho Chi Minh City, Viet Nam...
May 6, 2024: The Lancet. Microbe