Liwen Zhang, Taru M Flagan, Suvi Häkkinen, Stephanie A Chu, Jesse A Brown, Alex J Lee, Lorenzo Pasquini, Maria Luisa Mandelli, Maria Luisa Gorno-Tempini, Virginia E Sturm, Jennifer S Yokoyama, Brian S Appleby, Yann Cobigo, Bradford C Dickerson, Kimiko Domoto-Reilly, Daniel H Geschwind, Nupur Ghoshal, Neill R Graff-Radford, Murray Grossman, Ging-Yuek Robin Hsiung, Edward D Huey, Kejal Kantarci, Argentina Lario Lago, Irene Litvan, Ian R Mackenzie, Mario F Mendez, Chiadi U Onyike, Eliana Marisa Ramos, Erik D Roberson, Maria Carmela Tartaglia, Arthur W Toga, Sandra Weintraub, Zbigniew K Wszolek, Leah K Forsberg, Hilary W Heuer, Bradley F Boeve, Adam L Boxer, Howard J Rosen, Bruce L Miller, William W Seeley, Suzee E Lee
OBJECTIVE: Microtubule-associated protein tau (MAPT) mutations cause frontotemporal lobar degeneration, and novel biomarkers are urgently needed for early disease detection. We used task-free functional magnetic resonance imaging (fMRI) mapping, a promising biomarker, to analyze network connectivity in symptomatic and presymptomatic MAPT mutation carriers. METHODS: We compared cross-sectional fMRI data between 17 symptomatic and 39 presymptomatic carriers and 81 controls with (1) seed-based analyses to examine connectivity within networks associated with the 4 most common MAPT-associated clinical syndromes (ie, salience, corticobasal syndrome, progressive supranuclear palsy syndrome, and default mode networks) and (2) whole-brain connectivity analyses...
October 2023: Annals of Neurology