keyword
MENU ▼
Read by QxMD icon Read
search

Pneumococcal

keyword
https://www.readbyqxmd.com/read/29330244/primary-care-physicians-struggle-with-current-adult-pneumococcal-vaccine-recommendations
#1
Laura P Hurley, Mandy A Allison, Tamara Pilishvili, Sean T O'Leary, Lori A Crane, Michaela Brtnikova, Brenda L Beaty, Megan C Lindley, Carolyn B Bridges, Allison Kempe
INTRODUCTION: In 2012, the Advisory Committee on Immunization Practices recommended 13-valent pneumococcal conjugate vaccine (PCV13) in series with 23-valent pneumococcal polysaccharide vaccine (PPSV23) for at-risk adults ≥19; in 2014, it expanded this recommendation to adults ≥65. Primary care physicians' practice, knowledge, attitudes, and beliefs regarding these recommendations are unknown. METHODS: Primary care physicians throughout the U.S. were surveyed by E-mail and post from December 2015 to January 2016...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29330232/interventions-must-be-realistic-to-be-useful-and-completed-in-family-medicine
#2
EDITORIAL
Marjorie A Bowman, Dean A Seehusen, Anne Victoria Neale
Being realistic while helping our patients is this issue's theme. Given the volume of tasks required in family medicine, recommendations for improvements in direct care or care measurement cannot just be evidence-based but must also be realistic. On the list of realistic: ordering antipsychotics for symptoms of dementia in the elderly, despite recommendations to not do so; ordering antidepressants without fear that the patient could develop hypertension; mental health care providers in primary care offices; forced choice for opioid management; plus agenda setting for visit efficiency...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29329169/differences-in-immunization-site-pain-in-toddlers-vaccinated-with-either-the-10-or-the-13-valent-pneumococcal-conjugate-vaccine
#3
Johannes Trück, Sarah Kelly, Sena Jawad, Matthew D Snape, Merryn Voysey, Andrew J Pollard
We investigated immediate immunization pain in 12-month-old children randomized to receive a booster dose of either the 10- (PCV-10) or the 13-valent (PCV-13) pneumococcal conjugate vaccine. Pain was assessed using validated pain assessment tools and crying time. PCV-13 recipients had significantly higher scores on the observer-rated modified behavioral pain scale than did those receiving PCV-10, but the differences were small.Clinical trial registration at Clinicaltrials.gov (NCT01443416).
January 10, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29325173/immunogenicity-and-safety-of-pneumococcal-vaccination-in-patients-with-systemic-sclerosis
#4
Roger Hesselstrand, Johanna Nagel, Tore Saxne, Pierra Geborek, Lillemor Skattum, Meliha C Kapetanovic
Objective: To study the impact of disease and treatment with DMARDs on antibody response elicited by either pneumococcal conjugate vaccine (PCV13) or pneumococcal polysaccharide vaccine (PPV23) in patients with SSc. Methods: Forty-four SSc patients and 49 controls received a dose of either PCV13 or PPV23. Twelve patients were treated with DMARDs. Antibody levels to pneumococcal polysaccharides 6B and 23 F were measured before and 4-6 weeks after vaccination using ELISA...
January 8, 2018: Rheumatology
https://www.readbyqxmd.com/read/29324986/the-impact-of-the-13-valent-pneumococcal-conjugate-vaccine-on-pneumococcal-carriage-in-the-community-acquired-pneumonia-immunization-trial-in-adults-capita-study
#5
Anna M M van Deursen, Marlies A van Houten, Chris Webber, Michael Patton, Daniel Scott, Scott Patterson, Qin Jiang, William C Gruber, Beate Schmoele-Thoma, Diederick E Grobbee, Marc J M Bonten, Elisabeth A M Sanders
Background: The impact of pneumococcal conjugate vaccination on the prevalence of nasopharyngeal carriage with pneumococci and other bacteria in adults is unknown. The direct effects of the 13-valent pneumococcal conjugate vaccine (PCV13) in community dwelling older adults was investigated as part of the randomized controlled Community Acquired Pneumonia immunization Trial in Adults (CAPiTA). Methods: We determined the carriage of S. pneumoniae, S. aureus, H. influenzae, and M...
January 6, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29322942/purulent-pericarditis-an-unusual-complication-of-pneumococcal-pneumonia-a-case-report
#6
Ghizlane Zoulati, Ramatou Yèya Maïga, Rachid Kerzaz, Ghita Yahyaoui, Mustapha Harandou, Mustapha Mahmoud
Purulent pericarditis has become rare since the advent of antibiotics. Among the involved germs, S. pneumoniae remains the most implicated pathogen to evoke in principle, especially that prescription of systematic antibiotics for any febrile condition can considerably mask the clinical picture. A 36-year-old pregnant woman was visiting the emergency department for dyspnea and flu-like syndrom that had been going on for a week. The chest X-ray showed a white lung on the left and the transthoracic ultrasound revealed a pericardial effusion, resulting in pericardial drainage and pleural puncture that allows the evacuation of a purulent fluid...
January 11, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29322063/neurological-sequelae-of-adult-meningitis-in-africa-a-systematic-literature-review
#7
REVIEW
Drew W Goldberg, Mark W Tenforde, Hannah K Mitchell, Joseph N Jarvis
The high human immunodeficiency virus (HIV) prevalence in sub-Saharan Africa has markedly changed the epidemiology and presentation of adult meningitis. We conducted a systematic review using PubMed, Embase, Ovid, CENTRAL, and African Index Medicus to identify studies in Africa with data on neurological outcomes in adults after meningitis. We found 22 articles meeting inclusion criteria. From 4 studies with predominately pneumococcal meningitis, a median of 19% of survivors experienced hearing loss up to 40 days...
January 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29321514/flavin-reductase-contributes-to-pneumococcal-virulence-by-protecting-from-oxidative-stress-and-mediating-adhesion-and-elicits-protection-against-pneumococcal-challenge
#8
Giora I Morozov, Nurith Porat, Tatyana Kushnir, Hastyar Najmuldeen, Asad Adawi, Vered Chalifa-Caspi, Rachel Benisty, Ariel Ohayon, Ofir Liron, Shalhevet Azriel, Itai Malka, Shahar Dotan, Maxim Portnoi, Andrew A Piotrowski, Daniel Kafka, Barak Hajaj, Tali Fishilevich, Marilou Shagan, Michael Tal, Ron Ellis, Donald A Morrison, Andrea M Mitchell, Timothy J Mitchell, Ron Dagan, Hasan Yesilkaya, Yaffa Mizrachi Nebenzahl
Pneumococcal flavin reductase (FlaR) is known to be cell-wall associated and possess age dependent antigenicity in children. This study aimed at characterizing FlaR and elucidating its involvement in pneumococcal physiology and virulence. Bioinformatic analysis of FlaR sequence identified three-conserved cysteine residues, suggesting a transition metal-binding capacity. Recombinant FlaR (rFlaR) bound Fe2+ and exhibited FAD-dependent NADP-reductase activity, which increased in the presence of cysteine or excess Fe2+ and inhibited by divalent-chelating agents...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29318106/pneumococcal-vaccination-in-older-persons-where-are-we-today
#9
REVIEW
Paul Van Buynder, Robert Booy
Disease due to Streptococcus pneumoniae, the pneumococcus, remains a major source of illness in older persons. Globally, it remains the most important pathogen in respiratory infection deaths. Conjugated pneumococcal vaccines are used extensively in national pediatric programs, whereas a polysaccharide vaccine is used in all age groups, but mainly in the elderly and for high-risk groups. Recent data from the Netherlands led to the licensing in many countries of conjugated pneumococcal vaccines for older persons...
2018: Pneumonia
https://www.readbyqxmd.com/read/29317512/streptococcus-pneumoniae-modulates-staphylococcus-aureus-biofilm-dispersion-and-the-transition-from-colonization-to-invasive-disease
#10
Ryan M Reddinger, Nicole R Luke-Marshall, Shauna L Sauberan, Anders P Hakansson, Anthony A Campagnari
Streptococcus pneumoniae and Staphylococcus aureus are ubiquitous upper respiratory opportunistic pathogens. Individually, these Gram-positive microbes are two of the most common causative agents of secondary bacterial pneumonia following influenza A virus infection, and they constitute a significant source of morbidity and mortality. Since the introduction of the pneumococcal conjugate vaccine, rates of cocolonization with both of these bacterial species have increased, despite the traditional view that they are antagonistic and mutually exclusive...
January 9, 2018: MBio
https://www.readbyqxmd.com/read/29313476/serotype-distribution-of-clinical-streptococcus-pneumoniae-isolates-before-the-introduction-of-the-13-valent-pneumococcal-conjugate-vaccine-in-cambodia
#11
Malin Inghammar, Youlet By, Christina Farris, Thong Phe, Laurence Borand, Alexandra Kerleguer, Sophie Goyet, Vonthanak Saphonn, Chanleakhena Phoeung, Sirenda Vong, Blandine Rammaert, Charles Mayaud, Bertrand Guillard, Chadwick Yasuda, Matthew R Kasper, Gavin Ford, Steven W Newell, Ung Sam An, Buth Sokhal, Sok Touch, Paul Turner, Jan Jacobs, Mélina Messaoudi, Florence Komurian-Pradel, Arnaud Tarantola
Childhood vaccination with the 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in Cambodia in January 2015. Baseline data regarding circulating serotypes are scarce. All microbiology laboratories in Cambodia were contacted for identification of stored isolates of Streptococcus pneumoniae from clinical specimens taken before the introduction of PCV13. Available isolates were serotyped using a multiplex polymerase chain reaction method. Among 166 identified isolates available for serotyping from patients with pneumococcal disease, 4% were isolated from upper respiratory samples and 80% were from lower respiratory samples, and 16% were invasive isolates...
January 8, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29311363/il-1-signaling-prevents-alveolar-macrophage-depletion-during-influenza-and-streptococcus-pneumoniae-coinfection
#12
Shruti Bansal, Vijaya Kumar Yajjala, Christopher Bauer, Keer Sun
Influenza and bacterial coinfection is a significant cause of hospitalization and death in humans during influenza epidemics and pandemics. However, the fundamental protective and pathogenic mechanisms involved in this complex virus-host-bacterium interaction remain incompletely understood. In this study, we have developed mild to lethal influenza and Streptococcus pneumoniae coinfection models for comparative analyses of disease pathogenesis. Specifically, wild-type and IL-1R type 1-deficient (Il1r1-/- ) mice were infected with influenza virus and then superchallenged with noninvasive S...
January 8, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29311231/capsule-prolongs-survival-of-streptococcus-pneumoniae-during-starvation
#13
Shigeto Hamaguchi, M Ammar Zafar, Michael Cammer, Jeffrey N Weiser
Person-to-person transmission of Streptococcus pneumoniae (the pneumococcus) may occur via environmental sources in close contact with carriers. Pneumococcal polysaccharide capsules, the determinant of serotype (or type), are heterogeneous in structure and amount and these differences affect rates of transmission. In this study, we examined the contribution of capsule and its variations to the maintenance of pneumococcal viability under starvation conditions. S. pneumoniae retained its ability to colonize infant mice even after incubation for 24hrs in PBS at 25°C...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29309553/characteristics-and-serotype-distribution-of-childhood-cases-of-invasive-pneumococcal-disease-following-pneumococcal-conjugate-vaccination-in-england-and-wales-2006-2014
#14
Godwin Oligbu, Sarah Collins, Nick Andrews, Carmen L Sheppard, Norman K Fry, Mary P E Slack, Ray Borrow, Shamez N Ladhani
Background: The 7-valent and 13-valent pneumococcal conjugate vaccines (PCV7 and PCV13, respectively) are highly effective in preventing invasive pneumococcal disease (IPD) caused by vaccine serotypes. Vaccine failure (vaccine-type IPD after age-appropriate immunization) is rare. Little is known about the risk, clinical characteristics, or outcomes of PCV13 compared to PCV7 vaccine failure. Methods: Public Health England conducts IPD surveillance and provides a national reference service for serotyping pneumococcal isolates in England and Wales...
October 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29304069/naso-and-oropharyngeal-bacterial-carriage-in-nursing-home-residents-impact-of-multimorbidity-and-functional-impairment
#15
Anja Kwetkat, Wolfgang Pfister, Diana Pansow, Mathias W Pletz, Cornel C Sieber, Heike Hoyer
OBJECTIVE: From April 2013 to February 2014 we performed a multicentre prospective cross-sectional study in 541 German nursing home residents. We determined pharyngeal carriage of Streptococcus pneumoniae (primary objective) and other bacteria (secondary objective) in naso- and oropharyngeal swabs by culture-based standard procedures and explored the influence of multimorbidity and functional status on bacterial carriage. METHODS: Socio-demographic data, vaccination status, multimorbidity, nutrition and functional status defined by Comprehensive Geriatric Assessment were evaluated...
2018: PloS One
https://www.readbyqxmd.com/read/29304066/burden-of-invasive-pneumococcal-disease-among-children-in-rural-mozambique-2001-2012
#16
Betuel Sigaúque, Jennifer R Verani, Sérgio Massora, Delfino Vubil, Llorenç Quintó, Sozinho Acácio, Inácio Mandomando, Quique Bassat, Tacilta Nhampossa, Fabiana Pimenta, Charfudin Sacoor, Maria da Gloria Carvalho, Eusebio Macete, Pedro L Alonso
BACKGROUND: Invasive pneumococcal disease (IPD) is a major cause of illness and death among children worldwide. 10-valent pneumococcal conjugate vaccine (PCV10) was introduced as part of the Mozambican routine immunization program in April 2013. We characterized the IPD burden in a rural area of Mozambique before PCV introduction and estimated the potential impact of this intervention. METHODS: We conducted population-based surveillance for IPD, defined as S. pneumoniae isolated from blood or cerebrospinal fluid, among children <5 years old admitted to Manhiça District Hospital, a referral hospital in a rural area with high prevalence of human immunodiciency virus infection...
2018: PloS One
https://www.readbyqxmd.com/read/29303710/vaccinations-in-adults-with-rheumatoid-arthritis-in-an-era-of-new-disease-modifying-anti-rheumatic-drugs
#17
REVIEW
Pier Luigi Meroni, Daniela Zavaglia, Corrado Girmenia
Patients with rheumatoid arthritis are at greater risk of infectious morbidity and mortality due to disease-related abnormalities and use of immunosuppressive medications. Vaccinations are recommended by international guidelines among infection control strategies, but vaccination rates are reported to be still suboptimal in both America and Europe. Furthermore, with the increasing number of immunomodulatory medications used in RA patients, safety and efficacy of vaccinations in RA patients on such therapies have been questioned...
December 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29302645/community-acquired-pneumococcal-pneumonia-in-northwestern-nigeria-epidemiology-antimicrobial-resistance-and-outcome
#18
Garba Iliyasu, Farouq Dayyab Mohammad, Abdulrazaq Garba Habib
Background: Pneumococcus is the leading cause of community acquired pneumonia (CAP) worldwide, and the leading cause of mortality. Pneumococcal pneumonia is poorly studied in Nigeria. We describe the epidemiology including associated co-morbidities and outcome of pneumococcal pneumonia in North-western Nigeria. Material and methods: We conducted a prospective, hospital based study on patients with community acquired pneumococcal pneumonia. Detailed clinical evaluation and relevant laboratory investigations were carried out...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29301718/-immunisation-schedule-of-the-spanish-association-of-paediatrics-2018-recommendations
#19
David Moreno-Pérez, Francisco José Álvarez García, Javier Álvarez Aldeán, María José Cilleruelo Ortega, María Garcés Sánchez, Nuria García Sánchez, Ángel Hernández Merino, María Méndez Hernández, Manuel Merino Moína, Abián Montesdeoca Melián, Jesús Ruiz-Contreras
The Advisory Committee on Vaccines of the Spanish Association of Paediatrics annually publishes the immunisation schedule considered optimal for children resident in Spain, according to available evidence on current vaccines. Regarding funded immunisations, 2+1 strategy (2, 4, 11-12 months) with hexavalent (DTPa-IPV-Hib-HB) and 13-valent pneumococcal vaccines are recommended. Administration of the 6-year booster dose with DTPa is recommended, and a poliomyelitis dose for children who had received the 2+1 scheme, as well as Tdap vaccine for adolescents and pregnant women in every pregnancy between 27 and 32 weeks' gestation...
January 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29298677/the-variome-of-pneumococcal-virulence-factors-and-regulators
#20
Gustavo Gámez, Andrés Castro, Alejandro Gómez-Mejia, Mauricio Gallego, Alejandro Bedoya, Mauricio Camargo, Sven Hammerschmidt
BACKGROUND: In recent years, the idea of a highly immunogenic protein-based vaccine to combat Streptococcus pneumoniae and its severe invasive infectious diseases has gained considerable interest. However, the target proteins to be included in a vaccine formulation have to accomplish several genetic and immunological characteristics, (such as conservation, distribution, immunogenicity and protective effect), in order to ensure its suitability and effectiveness. This study aimed to get comprehensive insights into the genomic organization, population distribution and genetic conservation of all pneumococcal surface-exposed proteins, genetic regulators and other virulence factors, whose important function and role in pathogenesis has been demonstrated or hypothesized...
January 3, 2018: BMC Genomics
keyword
keyword
5295
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"