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https://www.readbyqxmd.com/read/28636411/asthma-and-influenza-vaccination-in-elderly-hospitalized-patients-matched-case-control-study-in-spain
#1
María Morales Suárez-Varela, Agustin Llopis, Estrella Fernandez-Fabrellas, Francisco Sanz, M Jose Perez-Lozano, Vicente Martin, Jenaro Astray, Jesús Castilla, Mikel Egurrola, Luis Force, Diana Toledo, Àngela Domínguez
OBJECTIVES: Influenza infection is an exacerbating factor for asthma, and its prevention is critical in managing asthmatic patients. We investigated the effect of influenza vaccination on asthmatic and non-asthmatic patients hospitalized with laboratory-confirmed influenza in Spain. METHODS: We made a matched case-control study to assess the frequency of hospitalization for influenza in people aged ≥65 years. Hospitalized patients with unplanned hospital admissions were recruited from 20 hospitals representing seven Spanish regions...
June 21, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28634177/pneumococcal-pulmonary-valve-endocarditis
#2
Apostolos Vrettos, Paula Mota, James Nash, Iain Thorp, Max Baghai, Max Baghai
Pulmonary valve endocarditis is an rare type of infective endocarditis (IE). Streptococcus pneumoniae is a pathogen that is uncommonly associated with IE. A 50 year-old man was referred to us to an incidental echocardiographic finding of a pulmonary valve vegetation. He had a recent admission for drainage of a scrotal abscess from which streptococcus pneumoniae was isolated, complicated by hospital acquired pneumonia and pulmonary embolism. Analysis using Polymerase Chain Reaction of the surgically resected mass revealed signs of 16S rDNA consistent with Streptococcus pneumoniae infection...
June 20, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28633889/serious-pneumococcal-disease-outbreak-in-men-exposed-to-metal-fume-detection-response-and-future-prevention-through-pneumococcal-vaccination
#3
Judith Ewing, Lynsey Patterson, Neil Irvine, Lorraine Doherty, Anne Loughrey, Joe Kidney, Carmen Sheppard, Georgia Kapatai, Norman K Fry, Mary Ramsay, Lucy Jessop
Welders and those exposed to metal fume are known to be at increased risk of pneumococcal pneumonia and invasive pneumococcal disease. Current UK guidance recommends that vaccination against pneumococcus be considered in those at risk of frequent or continuous occupational exposure to metal fume, taking into account the exposure control measures in place. We report an outbreak of serious pneumococcal disease that occurred between April and June 2015 among a multinational workforce exposed to metal fumes while working on the refurbishment of an oil rig in a Belfast shipyard...
June 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28633626/age-related-differences-in-management-and-outcomes-in-hospitalized-healthy-and-well-functioning-bacteremic-pneumococcal-pneumonia-patients-a-cohort-study
#4
Luis A Ruiz, Pedro P España, Ainhoa Gómez, Amaia Bilbao, Carmen Jaca, Amaia Arámburu, Alberto Capelastegui, Marcos I Restrepo, Rafael Zalacain
BACKGROUND: Limited data are available regarding fit and healthy patients with pneumonia at different ages. We evaluated the association of age with clinical presentation, serotype and outcomes among healthy and well-functioning patients hospitalized for bacteremic pneumococcal community-acquired pneumonia. METHODS: We performed a prospective cohort study of consecutive healthy and well-functioning patients hospitalized for this type of pneumonia. Patients were stratified into younger (18 to 64 years) and older (≥65 years) groups...
June 20, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28632827/-occult-bacteremia-in-s%C3%A3-tero-del-r%C3%A3-o-hospital-experience-after-pneumococcal-conjugated-vaccine
#5
Isolda Budnik, Alejandra Sandoval, Alejandra Prado, Marcela Labbé, Anamaría Peña, Tamara Viviani
BACKGROUND: Occult bacteremia (OB) is one of the possible diagnoses of children younger than 3 years with fever without source in the emergency room. OBJECTIVE: describe OB in the era after introduction of pneumococcal vaccine in Chile. PATIENTS AND METHODS: Prospective descriptive review of data of children with possible OB diagnosis, referred from the emergency department between 2010-2013. RESULTS: Possible OB was diagnosed on 391 patients...
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28630792/corneal-collagen-crosslinking-treatment-in-a-case-with-pneumococcal-keratitis
#6
Ayşe Bozkurt Oflaz, Banu Bozkurt, Ümit Kamış, Bengü Ekinci Köktekir
Bacterial keratitis is a serious ocular infectious disease that can threaten vision. The disease generally progresses rapidly and can lead to corneal scar, stromal abscess formation, perforation, and dissemination to adjacent tissues if not treated properly. Recent studies showed that corneal collagen crosslinking (CCC) using ultraviolet-A/riboflavin is effective in the treatment of bacterial keratitis refractory to topical antibiotic treatment. In addition to being bactericidal, CCC also decreases risk of perforation by strengthening the corneal collagen structure...
June 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28630198/genome-evolution-to-penicillin-resistance-in-serotype-3-streptococcus-pneumoniae-by-capsular-switching
#7
Naoko Chiba, Somay Y Murayama, Miyuki Morozumi, Satoshi Iwata, Kimiko Ubukata
Streptococcus pneumoniae of serotype 3 was collected from cases of invasive pneumococcal disease (n = 124) throughout Japan from April 2010 to March 2013. A penicillin-resistant S. pneumoniae (PRSP) isolate from an adult patient, KK0981 of serotype 3, was identified among these strains. Whole-genome analysis characterized this PRSP as a recombinant strain derived from PRSP of serotype 23F with the cps-locus (20.3 kb) replaced by that of a penicillin-susceptible strain of serotype 3.
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28630064/pneumolysin-dependent-calpain-activation-and-il-1%C3%AE-secretion-in-macrophages-infected-with-streptococcus-pneumoniae
#8
Rendong Fang, Rui Wu, Huihui Du, Meilan Jin, Yajing Liu, Guihua Lei, Bing Jiang, Zehui Lei, Yuanyi Peng, Kui Nie, Kohsuke Tsuchiya
Pneumolysin (PLY), a major virulence factor of Streptococcus pneumoniae, is a pore-forming cytolysin that modulates host innate responses contributing to host defense against and pathogenesis of pneumococcal infections. Interleukin-1α (IL-1α) has been shown to be involved in tissue damage in a pneumococcal pneumonia model, however, the mechanism by which this cytokine is produced during S. pneumoniae infection remains unclear. In this study, we examined the role of PLY in IL-1α production. Although the strains induced similar levels of pro-IL-1α expression, wild-type S...
June 19, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28628455/concurrent-infection-with-hepatitis-c-virus-and-streptococcus-pneumoniae
#9
Thomas J Marrie, Gregory J Tyrrell, Sumit R Majumdar, Dean T Eurich
Little is known about concurrent infection with hepatitis C virus (HCV) and Streptococcus pneumoniae, which causes invasive pneumococcal disease (IPD). We hypothesized that co-infection with HCV and S. pneumoniae would increase risk for death and complications. We captured sociodemographic and serologic data for adults with IPD in a population-based cohort study in northern Alberta, Canada, during 2000-2014. IPD patients infected with HCV were compared with IPD patients not infected with HCV for risk of in-hospital deaths and complications by using multivariable logistic regression...
July 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28626738/streptococcus-pneumoniae-serotype-prevalence-and-antibiotic-resistance-among-young-children-with-invasive-pneumococcal-disease-experience-from-a-tertiary-care-center-in-south-india
#10
Savitha Nagaraj, Bhuvanesh Sukhlal Kalal, Anand Manoharan, Anita Shet
INTRODUCTION: We performed a study to describe the clinical profile, antimicrobial susceptibility and prevalent serotypes of pneumococcal isolates from children with suspected invasive pneumococcal disease (IPD) admitted to a tertiary care hospital in South India. METHODS: Hospitalized children, ≤ 5 years with fever (>38 °C); increased respiratory rate or neurological symptoms were recruited, (as part of the Alliance for Surveillance of Invasive Pneumococci - ASIP - project) from January 2011 to March 2013...
June 2017: Germs
https://www.readbyqxmd.com/read/28626461/neoglycoconjugate-of-tetrasaccharide-representing-one-repeating-unit-of-the-streptococcus-pneumoniae-type-14-capsular-polysaccharide-induces-the-production-of-opsonizing-igg1-antibodies-and-possesses-the-highest-protective-activity-as-compared-to-hexa-and-octasaccharide
#11
Ekaterina A Kurbatova, Nelli K Akhmatova, Elina A Akhmatova, Nadezhda B Egorova, Natalya E Yastrebova, Elena V Sukhova, Dmitriy V Yashunsky, Yury E Tsvetkov, Marina L Gening, Nikolay E Nifantiev
Identifying protective synthetic oligosaccharide (OS) epitopes of Streptococcus pneumoniae capsular polysaccharides (CPs) is an indispensable step in the development of third-generation carbohydrate pneumococcal vaccines. Synthetic tetra-, hexa-, and octasaccharide structurally related to CP of S. pneumoniae type 14 were coupled to bovine serum albumin (BSA), adjuvanted with aluminum hydroxide, and tested for their immunogenicity in mice upon intraperitoneal prime-boost immunizations. Injections of the conjugates induced production of opsonizing anti-OS IgG1 antibodies (Abs)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28624420/biophysical-characterization-and-thermal-stability-of-pneumococcal-histidine-triad-protein-d-phtd-in-the-presence-of-zinc-and-manganese
#12
Salvador F Ausar, Kavisha Jayasundara, Lamees Akawi, Cristopher Roque, Anthony Sheung, Jian Hu, Marina Kirkitadze, Nausheen Rahman
The Pneumococcal Histidine Triad Protein D (PhtD) is believed to play a central role in pneumococcal metal ion homeostasis and has been proposed as a promising vaccine candidate against pneumococcal disease. To investigate for potential stabilizers, a panel of physiologically relevant metals was screened using the thermal shift assay and it was found that only Zn(2+) and Mn(2+) were able to increase PhtD melting temperature. Differential Scanning Calorimetry (DSC) analysis revealed a sequential unfolding of PhtD and the presence of at least 3 independent folding domains that can be stabilized by Zn(2+) and Mn(2+)...
June 14, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28623916/using-record-linkage-to-validate-notification-and-laboratory-data-for-a-more-accurate-assessment-of-notifiable-infectious-diseases
#13
Faye J Lim, Christopher C Blyth, Avram Levy, Parveen Fathima, Nicholas de Klerk, Carolien Giele, Hannah C Moore
BACKGROUND: Infectious disease burden is commonly assessed using notification data. Using retrospective record linkage in Western Australia, we described how well notification data captures laboratory detections of influenza, pertussis and invasive pneumococcal disease (IPD). METHODS: We linked data from the Western Australian Notifiable Infectious Diseases Database (WANIDD) and the PathWest Laboratory Database (PathWest) pertaining to the Triple I birth cohort, born in Western Australia in 1996-2012...
June 17, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28623156/trends-in-influenza-and-pneumococcal-vaccination-among-us-nursing-home-residents-2006-2014
#14
Carla L Black, Walter W Williams, Inaki Arbeloa, Natasa Kordic, Lindsay Yang, Tom MaCurdy, Chris Worrall, Jeffrey A Kelman
BACKGROUND: Institutionalized adults are at increased risk of morbidity and mortality from influenza and pneumococcal infection. Influenza and pneumococcal vaccination have been shown to be effective in reducing hospitalization and deaths due to pneumonia and influenza in this population. OBJECTIVE: To assess trends in influenza vaccination coverage among US nursing home residents from the 2005-2006 through 2014-2015 influenza seasons and trends in pneumococcal vaccination coverage from 2006 to 2014 among US nursing home residents, by state and demographic characteristics...
June 13, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28623109/serotype-distribution-of-streptococcus-pneumoniae-isolated-from-adult-respiratory-tract-infections-in-nationwide-japanese-surveillances-from-2006-to-2014
#15
Hisashi Shoji, Masayuki Maeda, Takahiro Takuma, Yoshihito Niki
BACKGROUND AND OBJECTIVE: Reports on the efficacy of pneumococcal conjugate vaccines (PCVs) have been received from many countries. However, in countries where the 7-valent PCV (PCV7) and 13-valent PCV (PCV13) were introduced, overall coverage of the serotypes by the vaccine gradually decreased due to pneumococcal serotype replacement. The aim of this study is to assess the distribution of pneumococcal serotypes and to also provide basic data on adult respiratory infection in Japan. METHODS: We analyzed 1086 Streptococcus pneumoniae strains that had been isolated from respiratory tract infection specimens in adult patients from 2006 to 2014...
June 13, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28619242/insurance-coverage-and-diabetes-quality-indicators-among-patients-with-diabetes-in-the-us-general-population
#16
Emily D Doucette, Joanne Salas, Jing Wang, Jeffrey F Scherrer
This study explores associations between health insurance and diabetes quality indicators. Data were obtained from 8305 patients with diabetes who reported no insurance, Medicaid or private insurance in the 2013 BRFSS in 26 states in the US. Six diabetes quality indicators were assessed: HgbA1c testing, foot exam, eye exam, influenza immunization, pneumococcal immunization and diabetes education. Logistic regression was performed comparing quality indicators by insurance group adjusting for covariates. Subjects with private insurance or Medicaid were more likely than the uninsured to have HgbA1c testing (OR=2...
June 12, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28619234/what-is-the-heterogeneity-in-the-impact-seen-with-pneumococcal-conjugate-vaccines-telling-us
#17
William P Hausdorff, Steve Black
Pneumococcal conjugate vaccines have proven highly effective in decreasing invasive disease and pneumonia in young children. However, there is considerable geographic variability in the impact of these vaccines on other disease endpoints and in other age groups. Investigation of the possible causes of this variability would greatly improve our understanding of pneumococcal pathophysiology and stimulate the effort to design more broadly effective vaccines.
June 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28618091/bacterial-transformation-comfa-is-a-dna-dependent-atpase-that-forms-complexes-with-comfc-and-dpra
#18
Amy Diallo, Hannah R Foster, Katarzyna A Gromek, Thomas N Perry, Annick Dujeancourt, Petya V Krasteva, Francesca Gubellini, Tanya G Falbel, Briana M Burton, Rémi Fronzes
Pneumococcal natural transformation contributes to genomic plasticity, antibiotic resistance development, and vaccine escape. Streptococcus pneumoniae, like many other naturally transformable species, has evolved sophisticated protein machinery for the binding and uptake of DNA. Two proteins encoded by the comF operon, ComFA and ComFC, are involved in transformation but their exact molecular roles remain unknown. In this study, we provide experimental evidence that ComFA binds to single stranded DNA (ssDNA) and has ssDNA-dependent ATPase activity...
June 15, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28617178/concentrations-of-pneumococcal-iga-and-igm-are-compromised-in-some-individuals-with-antibody-deficiencies
#19
Ainara Echeverría de Carlos, Ricardo Gómez de la Torre, Enrique García Carus, Luis Caminal Montero, Jose Bernardino Díaz López, Hector Suárez Casado, Luis Molinos Matin, Lourdes Tricas Aizpún, Stephen Harding, Antony R Parker
The response to pneumococcal vaccination is assessed by measurement of antigen specific IgG only and is compromised in a number of antibody deficiencies. We measured the concentrations of Pneumococcal IgA and IgM in individuals with both normal and abnormal pneumococcal capsular polysaccharide (PCP) IgG concentrations. A higher number of individuals had abnormal pre vaccination IgA and IgM concentrations below the lower limit of the normal range compared to the control group. Post vaccination a lower number of individuals had IgA and IgM concentrations below the upper limit of the normal range compared to the control group...
June 15, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/28616365/streptococcus-pneumoniae-otitis-media-pathogenesis-and-how-it-informs-our-understanding-of-vaccine-strategies
#20
REVIEW
Caroline Bergenfelz, Anders P Hakansson
PURPOSE OF REVIEW: This study aimed to review the literature regarding the mechanisms of transition from asymptomatic colonization to induction of otitis media and how the insight into the pathogenesis of otitis media has the potential to help design future otitis media-directed vaccines. RECENT FINDINGS: Respiratory viruses have long been shown to predispose individuals to bacterial respiratory infections, such as otitis media. Recent information suggests that Streptococcus pneumoniae, which colonize the nasopharynx asymptomatically, can sense potentially "threatening" changes in the nasopharyngeal environment caused by virus infection by upregulating specific sets of genes involved in biofilm release, dissemination from the nasopharynx to other sites, and protection against the host immune system...
2017: Current Otorhinolaryngology Reports
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