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Juho Jalkanen, Maija Hollmén, Sirpa Jalkanen, Harri Hakovirta
Atherosclerosis is an inflammatory process of the arterial wall. CD73 (also known as ecto-5'-nucleotidase) is a key regulator of cell signaling in response to inflammation and hypoxia, and may be important in the development of atherosclerosis. Recently, we have shown that high CD73 activity can be detected in the serum of patients with peripheral arterial disease (PAD). Using this same PAD patient cohort of 226 subjects with 38 femoral artery samples obtained during surgical endarcterectomy and control artery samples taken during autopsy, we explored the association of serum CD73 activity with overall atherosclerotic burden and the expression of CD73 in mature and developing plaques...
March 2017: Purinergic Signalling
Zhongzhao Teng, Jing He, Andrew J Degnan, Shengyong Chen, Umar Sadat, Nasim Sheikh Bahaei, James H F Rudd, Jonathan H Gillard
OBJECTIVE: Intraplaque hemorrhage is an increasingly recognized contributor to plaque instability. Neovascularization of plaque is believed to facilitate the entry of inflammatory and red blood cells (RBC). Under physiological conditions, neovessels are subject to mechanical loading from the deformation of atherosclerotic plaque by blood pressure and flow. Local mechanical environments around neovessels and their relevant pathophysiologic significance have not yet been examined. METHODS AND RESULTS: Four carotid plaque samples removed at endarcterectomy were collected for histopathological examination...
August 2012: Atherosclerosis
Eileen R Mulvihill, Jochen Jaeger, Rimli Sengupta, Walter L Ruzzo, Cecile Reimer, Sheila Lukito, Stephen M Schwartz
OBJECTIVE: The present study addresses the question, "Are plaque smooth muscles cells (SMCs) genetically distinct from medial SMCs as reflected by the ability to maintain a distinctive expression phenotype in vitro?" METHODS AND RESULTS: Multiple cell strains were developed from carotid endarcterectomy specimens, and quadruplicate array hybridizations were completed for each sample. A new normalization protocol was developed and used to analyze the data. Permutation analysis suggests that most of the significant differences in expression could not have occurred by chance...
July 2004: Arteriosclerosis, Thrombosis, and Vascular Biology
D Radak, B Radević, N Sternić, G Vucurević, B Petrović, N Ilijevski, S Radicević, A N Nesković, M Bojić
BACKGROUND AND PURPOSE: The prospective studies that have compared the outcomes of eversion and standard longitudinal carotid endarcterectomy (CEA) have been few and small and available data to reach definitive conclusions are still scarce. This prospective, non-randomized study sought to compare eversion and standard CEA for early and late mortality and morbidity and the incidence of late restenosis. METHODS: Between 1992 and 1997, we performed 2806 CEAs in 2469 patients (2124 eversion CEAs in 1859 patients and 682 standard CEAs in 610 patients)...
October 2000: Cardiovascular Surgery: Official Journal of the International Society for Cardiovascular Surgery
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