Eileen R Mulvihill, Jochen Jaeger, Rimli Sengupta, Walter L Ruzzo, Cecile Reimer, Sheila Lukito, Stephen M Schwartz
OBJECTIVE: The present study addresses the question, "Are plaque smooth muscles cells (SMCs) genetically distinct from medial SMCs as reflected by the ability to maintain a distinctive expression phenotype in vitro?" METHODS AND RESULTS: Multiple cell strains were developed from carotid endarcterectomy specimens, and quadruplicate array hybridizations were completed for each sample. A new normalization protocol was developed and used to analyze the data. Permutation analysis suggests that most of the significant differences in expression could not have occurred by chance...
July 2004: Arteriosclerosis, Thrombosis, and Vascular Biology