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https://www.readbyqxmd.com/read/29146481/central-obesity-is-the-key-component-in-the-association-of-metabolic-syndrome-with-left-ventricular-global-longitudinal-strain-impairment
#1
Wilson Cañon-Montañez, Angela B S Santos, Lisandra A Nunes, Julio C G Pires, Claudia M V Freire, Antonio L P Ribeiro, José G Mill, Marina Bessel, Bruce B Duncan, Maria Inês Schmidt, Murilo Foppa
INTRODUCTION AND OBJECTIVES: Subclinical systolic dysfunction is one of the proposed mechanisms for increased cardiovascular risk associated with metabolic syndrome (MS). This study investigated the association between MS and impaired left ventricular global longitudinal strain (GLS) and the role of each MS criteria in this association. METHODS: We analyzed a random sample of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) after excluding participants with prevalent heart disease...
November 13, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29140797/characterising-endourologist-learning-curve-during-percutaneous-nephrolithotomy-implications-on-occupational-dose-and-patients
#2
Jacobo Guiu-Souto, Carlos Otero, Daniel A Pérez-Fentes, Carlos Fernández-Baltar, Juan Francisco Sánchez-Garcia, Camilo García-Freire, Miguel Pombar-Cameán, Juan Pardo-Montero
In this study we have characterised the learning curve for percutaneous nephrolithotomy procedures over 301 cases for six years. Different surrogate parameters of clinical expertise have been used, such as dose area product, total procedure time, fluoroscopy time and personal equivalent doses. In addition, two different endourologists have been monitored; one of whom had specific Radiation Protection training (ICRP 85). Eye lens dose was estimated from thermoluminescent dosimeters. Significant differences were observed between both endourologists, especially in the fluoroscopy time...
November 15, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29139567/effectiveness-of-an-oral-health-educational-intervention-for-individuals-with-special-health-care-needs-from-a-southern-brazilian-city
#3
Andreia Drawanz Hartwig, Vanessa Müller Stüermer, Ivam Freire da Silva-Júnior, Lisandrea Rocha Schardosim, Marina Sousa Azevedo
AIM: To assess the effects of an oral health education strategy targeted at students with disabilities. METHODS: This quasi-experimental study included students aged 7 to 24 years. The intervention was conducted for 5 weeks and divided into 2 phases: (1) comprising supervised toothbrushing and educational activities to students; (2) verbal oral health instructions and oral hygiene demonstration targeted at the caregivers. A clinical examination was conducted to evaluate the dental debris and gingival bleeding before the intervention, and the Wilcoxon test was performed after phase 1 and 2 for comparisons between paired samples...
November 15, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/29138749/auris-system-providing-vibrotactile-feedback-for-hearing-impaired-population
#4
Felipe Alves Araujo, Fabricio Lima Brasil, Allison Candido Lima Santos, Luzenildo de Sousa Batista Junior, Savio Pereira Fonseca Dutra, Carlos Eduardo Coelho Freire Batista
Deafness, an issue that affects millions of people around the globe, is manifested in different intensities and related to many causes. This impairment negatively affects different aspects of the social life of the deaf people, and music-centered situations (concerts, religious events, etc.) are obviously not inviting for them. The Auris System was conceived to provide the musical experimentation for people who have some type of hearing loss. This system is able to extract musical information from audio and create a representation for music pieces using different stimuli, a new media format to be interpreted by other senses than the hearing...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29137394/measuring-plasma-levels-of-three-micrornas-can-improve-the-accuracy-for-identification-of-malignant-breast-lesions-in-women-with-bi-rads-4-mammography
#5
Julia Alejandra Pezuk, Thiago Luiz Araujo Miller, José Luiz Barbosa Bevilacqua, Alfredo Carlos Simões Dornellas de Barros, Felipe Eduardo Martins de Andrade, Luiza Freire de Andrade E Macedo, Vera Aguilar, Amanda Natasha Menardo Claro, Anamaria Aranha Camargo, Pedro Alexandre Favoretto Galante, Luiz F L Reis
A BI-RADS category of 4 from a mammogram indicates suspicious breast lesions, which require core biopsies for diagnosis and have an approximately one third chance of being malignant. Human plasma contains many circulating microRNAs, and variations in their circulating levels have been associated with pathologies, including cancer. Here, we present a novel methodology to identify malignant breast lesions in women with BI-RADS 4 mammography. First, we used the miRNome array and qRT-PCR to define circulating microRNAs that were differentially represented in blood samples from women with breast tumor (BI-RADS 5 or 6) in comparison to controls (BI-RADS 1 or 2)...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29133686/echocardiographic-improvements-following-transsphenoidal-surgery-for-acromegaly
#6
Antonio Ribeiro-Oliveira, Márta Korbonits, Claudia M V Freire
No abstract text is available yet for this article.
November 2017: Neurology India
https://www.readbyqxmd.com/read/29133238/mir-146a-targets-c-met-and-abolishes-colorectal-cancer-liver-metastasis
#7
Anne-Marie Bleau, Miriam Redrado, Estanislao Nistal-Villan, Maria Villalba, Francisco Exposito, Esther Redin, Arrate L de Aberasturi, Leyre Larzabal, Javier Freire, Javier Gomez-Roman, Alfonso Calvo
A major complication of colorectal cancer (CRC), one of the most frequent and deadly types of cancer, is disease progression via liver metastases. At this stage, very few treatment options are available for patients, and the disease remains incurable. Herein, we used a well-established mouse model of CRC liver metastasis (CLM) to identify new regulators of this process. Using serial transplantation of murine MC38 adenocarcinoma cells, we obtained liver metastatic variants that displayed extremely strong colonization abilities...
November 10, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29133208/homozygous-loss-of-function-brca1-variant-causing-a-fanconi-anemia-like-phenotype-a-clinical-report-and-review-of-previous-patients
#8
Bruna L Freire, Thais K Homma, Mariana F A Funari, Antônio M Lerario, Aline de Medeiros Leal, Elvira D Rodrigues Pereira Velloso, Alexsandra C Malaquias, Alexander A L Jorge
BACKGROUND: Fanconi Anemia (FA) is a rare and heterogeneous genetic syndrome. It is associated with short stature, bone marrow failure, high predisposition to cancer, microcephaly and congenital malformation. Many genes have been associated with FA. Previously, two adult patients with biallelic pathogenic variant in Breast Cancer 1 gene (BRCA1) had been identified in Fanconi Anemia-like condition. CLINICAL REPORT: The proband was a 2.5 year-old girl with severe short stature, microcephaly, neurodevelopmental delay, congenital heart disease and dysmorphic features...
November 10, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29131091/apathy-profile-in-parkinson-s-and-huntington-s-disease-a-comparative-cross-sectional-study
#9
Mário Sousa, Fradique Moreira, Joana Jesus-Ribeiro, Inês Marques, Flávia Cunha, Nádia Canário, António Freire, Cristina Januário
BACKGROUND/AIMS: Apathy is one of the most frequent, disabling and difficult-to-treat symptoms that show up in many neurodegenerative disorders. The aim of this study was to assess and compare apathy profile in Parkinson's and Huntington's patients using the same comprehensive instruments to measure apathy, cognition and depressive symptoms. MATERIALS AND METHODS: We consecutively assessed Parkinson's disease (PD) and Huntington's disease (HD) patients recruited from a Movement Disorders Unit...
November 13, 2017: European Neurology
https://www.readbyqxmd.com/read/29130988/recurrent-copy-number-variants-associated-with-syndromic-short-stature-of-unknown-cause
#10
Thais K Homma, Ana C V Krepischi, Tatiane K Furuya, Rachel S Honjo, Alexsandra C Malaquias, Debora R Bertola, Silvia S Costa, Ana P Canton, Rosimeire A Roela, Bruna L Freire, Chong A Kim, Carla Rosenberg, Alexander A L Jorge
BACKGROUND/AIMS: Genetic imbalances are responsible for many cases of short stature of unknown etiology. This study aims to identify recurrent pathogenic copy number variants (CNVs) in patients with syndromic short stature of unknown cause. METHODS: We selected 229 children with short stature and dysmorphic features, developmental delay, and/or intellectual disability, but without a recognized syndrome. All patients were evaluated by chromosomal microarray (array-based comparative genomic hybridization/single nucleotide polymorphism array)...
November 9, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29117561/ronin-governs-early-heart-development-by-controlling-core-gene-expression-programs
#11
Jun Fujita, Pablo Freire, Cristian Coarfa, Ashley L Benham, Preethi Gunaratne, Michael D Schneider, Marion Dejosez, Thomas P Zwaka
Ronin (THAP11), a DNA-binding protein that evolved from a primordial DNA transposon by molecular domestication, recognizes a hyperconserved promoter sequence to control developmentally and metabolically essential genes in pluripotent stem cells. However, it remains unclear whether Ronin or related THAP proteins perform similar functions in development. Here, we present evidence that Ronin functions within the nascent heart as it arises from the mesoderm and forms a four-chambered organ. We show that Ronin is vital for cardiogenesis during midgestation by controlling a set of critical genes...
November 7, 2017: Cell Reports
https://www.readbyqxmd.com/read/29117195/biological-and-phylogenetic-characteristics-of-west-african-lineages-of-west-nile-virus
#12
Gamou Fall, Nicholas Di Paola, Martin Faye, Moussa Dia, Caio César de Melo Freire, Cheikh Loucoubar, Paolo Marinho de Andrade Zanotto, Ousmane Faye, Amadou Alpha Sall
The West Nile virus (WNV), isolated in 1937, is an arbovirus (arthropod-borne virus) that infects thousands of people each year. Despite its burden on global health, little is known about the virus' biological and evolutionary dynamics. As several lineages are endemic in West Africa, we obtained the complete polyprotein sequence from three isolates from the early 1990s, each representing a different lineage. We then investigated differences in growth behavior and pathogenicity for four distinct West African lineages in arthropod (Ap61) and primate (Vero) cell lines, and in mice...
November 8, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29114544/dendritic-cell-therapy-in-melanoma
#13
REVIEW
Carmen Alvarez-Dominguez, Ricardo Calderón-Gonzalez, Hector Terán-Navarro, David Salcines-Cuevas, Almudena Garcia-Castaño, Javier Freire, Javier Gomez-Roman, Fernando Rivera
Dendritic cell (DC) vaccines are cancer vaccines used currently as melanoma therapies. They act as adjuvants initiating the immune responses, but not only as they can also have effector activities redirecting cytotoxic CD8(+) T cells against melanoma. Ex vivo preparation of monocyte derived DCs has been implemented to produce large numbers of DCs for clinical therapy, highlighting the necessity of activate DC s to produce Th1 cytokines, especially TNF-a and IL-12 with potent anti-tumour actions. Several clinical trials both in the European Union and USA are open currently using DC vaccines, alone or in combination with other immunotherapies...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29114202/estradiol-uses-different-mechanisms-in-astrocytes-from-the-hippocampus-of-male-and-female-rats-to-protect-against-damage-induced-by-palmitic-acid
#14
Laura M Frago, Sandra Canelles, Alejandra Freire-Regatillo, Pilar Argente-Arizón, Vicente Barrios, Jesús Argente, Luis M Garcia-Segura, Julie A Chowen
An excess of saturated fatty acids can be toxic for tissues, including the brain, and this has been associated with the progression of neurodegenerative diseases. Since palmitic acid (PA) is a free fatty acid that is abundant in the diet and circulation and can be harmful, we have investigated the effects of this fatty acid on lipotoxicity in hippocampal astrocytes and the mechanism involved. Moreover, as males and females have different susceptibilities to some neurodegenerative diseases, we accessed the responses of astrocytes from both sexes, as well as the possible involvement of estrogens in the protection against fatty acid toxicity...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29111846/investigation-of-cav1-cav2-rs4236601-and-cdkn2b-as1-rs2157719-in-primary-open-angle-glaucoma-patients-from-brazil
#15
Hugo Freire Nunes, Galina Ananina, Vital Paulino Costa, Nilson Ivo Tonin Zanchin, José Paulo Cabral de Vasconcellos, Mônica Barbosa de Melo
Large-scale genome-wide association studies have identified several susceptibility variants associated with the risk of primary open-angle glaucoma (POAG), among which rs4236601 (CAV1/CAV2) at chromosome 7q31 and rs2157719 at chromosome 9p21 (CDKN2B-AS1). The purpose of this study was to investigate whether these variants contribute to the incidence of POAG in a sample of the Brazilian Southeastern population and to determine the best-fitted genetic model for these single nucleotide polymorphisms (SNPs). A case-control study with 557 individuals, 310 with POAG, and 247 controls was conducted through PCR and direct sequencing...
November 7, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29111263/a-new-perspective-of-an-old-villain-revisiting-biomarkers-of-caries-development
#16
Irlan Almeida Freires, José A Lemos, Jacqueline Abranches
No abstract text is available yet for this article.
October 21, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29108795/severity-of-copd-and-its-relationship-with-il-10
#17
Bruna S A Silva, Fábio S Lira, Dionei Ramos, Juliana S Uzeloto, Fabrício Eduardo Rossi, Ana Paula C F Freire, Rebeca N Silva, Iara B Trevisan, Luis Alberto Gobbo, Ercy M C Ramos
BACKGROUND: The present study was designed to compare inflammatory and metabolic responses according to severity of airflow among patients with COPD and to verify the relationship between pulmonary function, body composition, metabolic and inflammatory profile. METHODS: Fifty-one patients with mild to very severe COPD were recruited and divided according lung function in Mild-moderate (GOLD 1-2) n= 21; Severe (GOLD 3) n=25 and Very severe (GOLD 4) n=5. Patients were submitted to assessments of lung function (spirometry), functional exercise capacity (6-min walk test), body composition (Octopolar bioelectrical impedance), metabolic profile (glucose, triglycerides, total cholesterol, HDL-cholesterol and albumin (colorimetric assay)) and inflammatory profile (cytokines: IL-6, IL-10, TNF-α and IL-15 (ELISA))...
November 3, 2017: Cytokine
https://www.readbyqxmd.com/read/29106946/orodispersible-tablets-containing-taste-masked-solid-lipid-pellets-with-metformin-hydrochloride-influence-of-process-parameters-on-tablet-properties
#18
Gustavo Freire Petrovick, Peter Kleinebudde, Jörg Breitkreutz
Compaction of multiparticulates into tablets, particularly into orodispersible tablets (ODTs), is challenging. The compression of pellets, made by solid lipid extrusion/spheronization processes, presents peculiar difficulties since solid lipids usually soften or melt at relatively low temperature ranges and due to applied mechanical forces. Until now, there are no reports in literature about the development of ODTs based on solid lipid pellets. To investigate the feasibility of producing such tablets, a design of experiment (DoE) approach was performed to elucidate the influence of compression force and amount of two co-processed excipients (Ludiflash(®) and Parteck(®) ODT) on properties of the tablets (friability, tensile strength, and disintegration time)...
October 26, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29106904/prothymosin-%C3%AE-interacts-with-set-anp32a-and-anp32b-and-other-cytoplasmic-and-mitochondrial-proteins-in-proliferating-cells
#19
Pablo Barbeito, Concepción S Sarandeses, Cristina Díaz-Jullien, Juan Muras, Guillermo Covelo, David Moreira, Carmen Freire-Cobo, Manuel Freire
Prothymosin α (ProTα) is an acidic protein with a nuclear role related to the chromatin activity through its interaction with histones in mammalian cells. ProTα acts as an anti-apoptotic factor involved in the control of the apoptosome activity in the cytoplasm, however the mechanisms underlying this function are still known. ProTα shares similar biological functions with acidic nuclear-cytoplasmic shuttling proteins included in SET and ANP32 family members. Using affinity chromatography, co-immunoprecipitation and chemical cross-linking, we demonstrate that ProTα interacts with SET, ANP32A and ANP32B proteins...
October 30, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29105785/a-color-code-for-glycosaminoglycans-identification-by-means-of-polyacrylamide-gel-electrophoresis-stained-with-the-cationic-carbocyanine-dye-stains-all
#20
João Pedro Souza Andrade, Caroline Pacheco Oliveira, Ana Maria Freire Tovar, Paulo Antonio de Souza Mourão, Eduardo Vilanova
Cationic dyes such as toluidin blue are commonly employed to visualize Glycosaminoglycans (GAGs) on electrophoresis gels; however, the carbocyanine based dye Stains-all has been increasingly used to stain the non-sulfated hyaluronic acid and other GAGs in submicrogram quantities. In this short communication, we demonstrate that Stains-all is able to stain the most common GAGs on polyacrylamide gels with distinct and contrasting colors in a reproducible manner. We also show that this staining method is useful to identify GAGs present both in mixtures and in submicrogram quantities...
November 6, 2017: Electrophoresis
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