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Helena Passos, Teresa B V Dinis, Emanuel V Capela, Maria V Quental, Joana Gomes, Judite Resende, Pedro P Madeira, Mara G Freire, João A P Coutinho
In the past decade, the remarkable potential of ionic-liquid-based aqueous biphasic systems (IL-based ABSs) to extract and purify a large range of valued-added biocompounds has been demonstrated. However, the translation of lab-scale experiments to an industrial scale has been precluded by a poor understanding of the molecular-level mechanisms ruling the separation or partition of target compounds between the coexisting phases. To overcome this limitation, we carried out a systematic evaluation of specific interactions, induced by ILs and several salts used as phase-forming components, and their impact on the partition of several solutes in IL-based ABSs...
March 15, 2018: Physical Chemistry Chemical Physics: PCCP
Walkiria Samuel Avila, Antônio Fernando Diniz Freire, Alexandre Anderson de Sousa Soares, Ana Neri Rodrigues Epitácio Pereira, José Carlos Nicolau
No abstract text is available yet for this article.
January 2018: Arquivos Brasileiros de Cardiologia
Isabela Cristina Cordeiro Farias, Taciana Furtado Mendonça-Belmont, Andreia Soares da Silva, Kleyton Palmeira do Ó, Felipe Ferreira, Fernanda Silva Medeiros, Luydson Richardson da Silva Vasconcelos, Marcos André Cavalcanti Bezerra, Aderson da Silva Araújo, Patricia Muniz Mendes Freire de Moura, Betânia Lucena Domingues Hatzlhofer, Ana Claudia Mendonça Dos Anjos, Maria do Socorro de Mendonça Cavalcanti
The SOD2 polymorphism Val16Ala T→C influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with the vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children with SCA aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC and CC were more frequent in patients with VOC or ASS (p=0...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Antonio N da Silva, Antonio B S Neto, Alcemira C Oliveira, Manoel C Junior, Jose A L Junior, Paulo T C Freire, Josué M Filho, Alcineia C Oliveira, Rossano Lang
High temperature and pressure effects on the physicochemical properties of binary oxides catalysts were investigated. The nanocomposites catalysts comprising of CeAl, CeMn and NiAl were characterized through various physicochemical techniques. A study of the temperature and pressure induced phenomena monitored by Raman spectroscopy was proposed and discussed. Spectral modifications of the Raman modes belonging to the CeMn suggest structural changes in the solid due to the MnO2 phase oxidation with increasing temperature...
February 26, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Fernanda B Campagnollo, Larissa P Margalho, Bruna A Kamimura, Marcelo D Feliciano, Luisa Freire, Letícia S Lopes, Verônica O Alvarenga, Vasco A P Cadavez, Ursula Gonzales-Barron, Donald W Schaffner, Anderson S Sant'Ana
Artisanal raw milk cheeses are highly appreciated dairy products in Brazil and ensuring their microbiological safety has been a great need. This study reports the isolation and characterization of lactic acid bacteria (LAB) strains with anti-listerial activity, and their effects on Listeria monocytogenes during refrigerated shelf-life of soft Minas cheese and ripening of semi-hard Minas cheese. LAB strains (n = 891) isolated from Minas artisanal cheeses (n = 244) were assessed for anti-listerial activity by deferred antagonism assay at 37 °C and 7 °C...
August 2018: Food Microbiology
Patrícia Flávia Quaresma, Cristiana Ferreira Alves de Brito, Jeronimo Marteleto Nunes Rugani, Janaína de Moura Freire, Rodrigo de Paula Baptista, Elizabeth Castro Moreno, Raquel Carvalho Gontijo, Felipe Dutra Rego, Joaquim Edemilson Diniz, Maria Norma Melo, Célia Maria Ferreira Gontijo
American tegumentary leishmaniasis (ATL) samples obtained from the lesions of patients with typical (n = 25, 29%), atypical (n = 60, 69%) or both (n = 2%) clinical manifestations were analysed by multilocus enzyme electrophoresis, hsp70 restriction-fragment length polymorphism (PCR-RFLP), hsp70 sequencing and phylogenetics methods. The hsp70 PCR-RFLP analysis revealed two different profiles whose the most samples differed from those expected for Leishmania braziliensis and the other Leishmania species tested: of 39 samples evaluated, two (5%) had a restriction profile corresponding to L...
March 12, 2018: Parasitology
Anne Caroline Oenning, Alexandre Rodrigues Freire, Ana Cláudia Rossi, Felippe Bevilacqua Prado, Paulo Henrique Ferreira Caria, Lourenço Correr-Sobrinho, Francisco Haiter-Neto
OBJECTIVES: Previous studies have suggested a relationship between resorption in second molars and pressure from the eruptive force of the third molar. The aim of this study was to simulate functional forces in a mandible model by means of finite element analysis and then assess the biomechanical response produced by impacted third molars on the roots of the second molar. MATERIALS AND METHODS: A cone beam computed tomography scan presenting an impacted mandibular third molar was segmented (Mimics V17 software)...
March 10, 2018: Clinical Oral Investigations
Bruna Pedroso Canever, Marta Lenise do Prado, Diana Coelho Gomes, Vânia Marli Schubert Backes, Bruna Helena de Jesus
BACKGROUND: Specific pedagogical training for teaching in the area of health emerges with the goal of creating critical and reflective professionals and as a necessary challenge to university teaching, where there is reflection on self-awareness, consciousness, and the incompleteness of being. OBJECTIVES: This study aims to understand how Freire's critical consciousness is expressed in the pedagogical practice of health teachers. DESIGN: This study is a qualitative study that is descriptive, exploratory, and analytical...
March 3, 2018: Nurse Education Today
Juan Gómez Rivas, Francesco Giganti, Mario Álvarez-Maestro, María Jose Freire, Veeru Kasivisvanathan, Luis Martinez-Piñero, Mark Emberton
CONTEXT: The indeterminate multiparametric prostate magnetic resonance image (mpMRI) lesion is one which cannot be classified as "positive" or "negative" for suspected cancer. Currently, there is no consensus on how to manage patients with indeterminate mpMRIs where areas cannot be classified as positives or negatives (Prostate Imaging Reporting and Data System [PI-RADS] 3 or Likert 3). OBJECTIVE: To define the concept of indeterminate lesion and describe the management strategies that may be adopted for these patients...
March 7, 2018: European Urology Focus
Alejandro Avilés-Reyes, Irlan Almeida Freires, Jessica K Kajfasz, Dicler Barbieri, James H Miller, José A Lemos, Jacqueline Abranches
We report the whole genome sequence (WGS) of the serotype e Cbm+ strain LAR01 of Streptococcus mutans, a dental pathogen frequently associated with extra-oral infections. The LAR01 genome is a single circular chromosome of 2.1 Mb with a GC content of 36.96%. The genome contains 15 PTS gene clusters, 7 cell wall-anchored (LPxTG) proteins, all genes required for the development of natural competence and genes coding for mutacins VI and K8. Interestingly, the cbm gene is genetically linked to a putative type VII secretion system that has been found in Mycobacteria and few other gram-positive bacteria...
March 9, 2018: Molecular Oral Microbiology
Mayara Lütchemeyer de Freitas, Clarissa Vasconcelos de Oliveira, Fernanda Kulinski Mello, Vinícius Rafael Funck, Michele Rechia Fighera, Luiz Fernando Freire Royes, Ana Flávia Furian, James W Larrick, Mauro Schneider Oliveira
Na+ , K+ -ATPase is an important regulator of brain excitability. Accordingly, compelling evidence indicates that impairment of Na+ , K+ -ATPase activity contributes to seizure activity in epileptic mice and human with epilepsy. In addition, this enzyme is crucial for plasma membrane transport of water, glucose and several chemical mediators, including glutamate, the major excitatory transmitter in the mammalian brain. Since glucose hypometabolism and increased glutamate levels occur in clinical and experimental epilepsy, we aimed the present study to investigate whether activation of Na+ ,K+ -ATPase activity with specific antibody (DRRSAb) would improve glucose uptake and glutamate release in pilocarpine-treated mice...
March 6, 2018: Neuroscience
Ivna V Freire, Cezar A Casotti, Ícaro J S Ribeiro, Jonas R D Silva, Ana A L Barbosa, Rafael Pereira
The angiotensin-converting enzyme insertion/deletion (I/D) gene polymorphism has been widely reported as being associated with hypertension; however, most studies do not consider environmental/behavioral factors. This study aimed to investigate the relationship among angiotensin-converting enzyme insertion/deletion gene polymorphism, environmental/behavioral factors, and hypertension in community-dwelling elderly individuals. All community-dwelling older adults from Aiquara, Bahia, Brazil, were invited to take part in this study...
March 9, 2018: Journal of Clinical Hypertension
J Martos-Perez, S Freire-Prudencio, M Llorente-Comi, R Ayuda-Pascual, A Gonzalez-Navarro
INTRODUCTION: Autism is a heterogeneous disorder. The possibility of determining its characteristics over time will have a great impact on the prognosis and predictions that can be made. In that regard, the intelligence quotient and its possible stability throughout the life cycle can help to better define the phenotype of the disorder and its associated needs. DEVELOPMENT: Longitudinal studies show a certain level of stability in intelligence quotient scores, especially starting from the school years...
March 1, 2018: Revista de Neurologia
Renuka E Peterson, Grace Freire, Cynthia J Marino, Saadeh B Jureidini
Right ventricular-dependent coronary circulation (RVDCC) is associated with pulmonary atresia with intact ventricular septum and is defined by two or more epicardial coronary arteries with atresia or severe stenosis resulting in the dependency of coronary supply by retrograde flow. The hypothesis of this study is that coronary Doppler flow patterns on echocardiography can be used to distinguish patients with RVDCC. Between 2007 and 2016, we reviewed 16 patients with pulmonary atresia or critical pulmonary stenosis...
March 8, 2018: Pediatric Cardiology
Clara Lopes Novo, Biola-Maria Javierre, Jonathan Cairns, Anne Segonds-Pichon, Steven W Wingett, Paula Freire-Pritchett, Mayra Furlan-Magaril, Stefan Schoenfelder, Peter Fraser, Peter J Rugg-Gunn
Transcriptional enhancers, including super-enhancers (SEs), form physical interactions with promoters to regulate cell-type-specific gene expression. SEs are characterized by high transcription factor occupancy and large domains of active chromatin, and they are commonly assigned to target promoters using computational predictions. How promoter-SE interactions change upon cell state transitions, and whether transcription factors maintain SE interactions, have not been reported. Here, we used promoter-capture Hi-C to identify promoters that interact with SEs in mouse embryonic stem cells (ESCs)...
March 6, 2018: Cell Reports
Cristiane S Paula, Jair J Mari, Isabel Altenfelder Santos Bordin, Euripedes C Miguel, Isabela Fortes, Natalia Barroso, Luis Augusto Rohde, Evandro Silva Freire Coutinho
PURPOSE: The purpose of the study is to identify early vulnerabilities for psychiatric disorders among Brazilian elementary school children, controlling for familial and community adversities. METHODS: This is a cross-sectional study examining the association between child psychiatric disorders and potential early vulnerabilities (disability, low intellectual quotient, and negative dimensions of the temperament trait self-directedness (low resourcefulness, low purposefulness, low enlightened second nature), controlling for the potential confounders: familial and community adversities...
March 6, 2018: Social Psychiatry and Psychiatric Epidemiology
Maria Cecília Freire de Melo, Thuanny Silva de Macedo, Julianelly Alves Biserra, Karina Luz Cavalcanti Rodrigues, Mônica Cruz, Aurora Karla de Lacerda Vidal
AIM: To report a case of a pediatric patient carrier of myelodysplastic syndrome (MDS) with severe oral infectious disease, in which antimicrobial photodynamic therapy (aPDT) was used as a therapeutic choice to support systemic treatment. METHODS AND RESULTS: This case report refers to a 1-year-old male patient with MDS and hospitalized for investigation and treatment of complications at a Pediatric Oncology and Hematology Center in Recife/PE, Brazil. The intraoral examination revealed a violaceous lesion surrounding the lower incisor teeth, which progressed with alteration of color to milky yellowish white, compromising the entire lower gingival border, leading to tooth mobility and consequent loss of teeth 71 and 81...
March 6, 2018: Special Care in Dentistry
Priscila Leal da Silva, Igor Leite Freire, Júlio Cesar Santos Sampaio
We consider a family of homogeneous nonlinear dispersive equations with two arbitrary parameters. Conservation laws are established from the point symmetries and imply that the whole family admits square integrable solutions. Recursion operators are found for two members of the family investigated. For one of them, a Lax pair is also obtained, proving its complete integrability. From the Lax pair, we construct a Miura-type transformation relating the original equation to the Korteweg-de Vries (KdV) equation...
February 2018: Proceedings. Mathematical, Physical, and Engineering Sciences
Corneliu Sima, Eduardo Montero, Daniel Nguyen, Marcelo Freire, Paul Norris, Charles N Serhan, Thomas E Van Dyke
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
March 2, 2018: Scientific Reports
Joana Carrola, Ricardo J B Pinto, Maryam Nasirpour, Carmen S R Freire, Ana M Gil, Conceição Santos, Helena Oliveira, Iola F Duarte
The expansion of biomedical and therapeutic applications of silver nanoparticles (AgNPs) raises the need to further understand their biological effects on human cells. In this work, NMR metabolomics has been applied to reveal the metabolic effects of AgNPs toward human hepatoma (HepG2) cells, which are relevant with respect to nanoparticle accumulation and detoxification. Cellular responses to widely disseminated citrate-coated AgNPs (Cit30) and to emergent biogenic AgNPs prepared using an aqueous plant extract as reducing and stabilizing agent (GS30) have been compared with a view to assess the influence of nanoparticle coating on the metabolic effects produced...
March 9, 2018: Journal of Proteome Research
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