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https://www.readbyqxmd.com/read/28808459/evaluation-of-apically-extruded-debris-during-root-canal-retreatment-using-protaper-next-and-reciproc-in-severely-curved-canals
#1
Giselle Nevares, Kaline Romeiro, Diana Albuquerque, Felipe Xavier, Howard Fogel, Laila Freire, Rodrigo Cunha
INTRODUCTION: To compare the apical extrusion of debris produced during root obturating material removal from severely curved root canals using either Reciproc (REC) or ProTaper Next (PTN) systems. METHODS AND MATERIALS: Twenty-six mesial canals of lower molars were instrumented, filled and allocated into two groups (n=13). Micro-computed tomographic images were performed to determine the root canal configuration (Vertucci's type IV) and initial volume of obturation...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28807027/health-related-quality-of-life-in-the-brazilian-amazon-a-population-based-cross-sectional-study
#2
Marcus Tolentino Silva, Monica Caicedo Roa, Tais Freire Galvao
BACKGROUND: To analyze perceptions of health-related quality of life and associated factors in populations from the Manaus Metropolitan Region. METHODS: We conducted a population-based cross-sectional study from May to August 2015. Adults aged 18 years and older were selected using probabilistic three-phase cluster sampling and stratified by sex and age, based on official estimates. Quality of life data were collected using the European Quality of Life 5-Dimensions 3-Levels (EQ-5D-3L) along with socioeconomic, demographic, and health perception data...
August 14, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28804451/behavioral-changes-over-time-following-ayahuasca-exposure-in-zebrafish
#3
Robson Savoldi, Daniel Polari, Jaquelinne Pinheiro-da-Silva, Priscila F Silva, Bruno Lobao-Soares, Mauricio Yonamine, Fulvio A M Freire, Ana C Luchiari
The combined infusion of Banisteriopsis caapi stem and Psychotria viridis leaves, known as ayahuasca, has been used for centuries by indigenous tribes. The infusion is rich in N, N-dimethyltryptamine (DMT) and monoamine oxidase inhibitors, with properties similar to those of serotonin. Despite substantial progress in the development of new drugs to treat anxiety and depression, current treatments have several limitations. Alternative drugs, such as ayahuasca, may shed light on these disorders. Here, we present time-course behavioral changes induced by ayahuasca in zebrafish, as first step toward establishing an ideal concentration for pre-clinical evaluations...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28802161/physicochemical-analysis-of-permian-coprolites-from-brazil
#4
M I C Rodrigues, J H da Silva, F Eroni P Santos, P Dentzien-Dias, J C Cisneros, A S de Menezes, P T C Freire, B C Viana
In this paper we performed the study of two coprolites (fossilized feces) collected from the exposed levels of the Pedra de Fogo Formation, Parnaiba Sedimentary Basin, and Rio do Rasto Formation, Paraná Sedimentary Basin, both of the Palaeozoic era (Permian age). They were characterized using X-ray diffractometry, infrared, Raman and energy dispersive spectroscopy techniques in order to aid our understanding of the processes of fossilization and to discuss issues related to the feeding habits of the animals which generated those coprolites, probably cartilaginous fishes...
August 8, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28798750/heme-oxygenase-1-expression-contributes-to-the-immunoregulation-induced-by-fasciola-hepatica-and-promotes-infection
#5
Paula Carasi, Ernesto Rodríguez, Valeria da Costa, Sofía Frigerio, Natalie Brossard, Verónica Noya, Carlos Robello, Ignacio Anegón, Teresa Freire
Fasciola hepatica, also known as the liver fluke, is a trematode that infects livestock and humans causing fasciolosis, a zoonotic disease of increasing importance due to its worldwide distribution and high economic losses. This parasite immunoregulates the host immune system by inducing a strong Th2 and regulatory T immune response by immunomodulating dendritic cell (DC) maturation and alternative activation of macrophages. In this paper, we show that F. hepatica infection in mice induces the upregulation of heme-oxygenase-1 (HO-1), the rate-limiting enzyme in the catabolism of free heme that regulates the host inflammatory response...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28797396/an-80-year-old-man-with-asbestos-exposure-presenting-with-respiratory-distress
#6
Anirudh Aron, Alexander E Urban, Julio Alberto Lanfranco, Amado Xavier Freire, Ivan H Romero-Legro
No abstract text is available yet for this article.
August 2017: Chest
https://www.readbyqxmd.com/read/28793962/simultaneous-extraction-and-concentration-of-water-pollution-tracers-using-ionic-liquid-based-systems
#7
Teresa B V Dinis, Helena Passos, Diana L D Lima, Ana C A Sousa, João A P Coutinho, Valdemar I Esteves, Mara G Freire
Human activities are responsible for the release of innumerous substances into the aquatic environment. Some of these substances can be used as pollution tracers to identify contamination sources and to prioritize monitoring and remediation actions. Thus, their identification and quantification are of high priority. However, due to their presence in complex matrices and at significantly low concentrations, a pre-treatment/concentration step is always required. As an alternative to the currently used pre-treatment methods, mainly based on solid-phase extractions, aqueous biphasic systems (ABS) composed of ionic liquids (ILs) and K3C6H5O7 are here proposed for the simultaneous extraction and concentration of mixtures of two important pollution tracers, caffeine (CAF) and carbamazepine (CBZ)...
July 29, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28793100/falls-in-institutionalized-older-adults-risks-consequences-and-antecedents
#8
Antonio Herculano de Araújo, Anna Cláudia Freire de Araújo Patrício, Milenna Azevedo Minhaqui Ferreira, Brenda Feitosa Lopes Rodrigues, Thayná Dias Dos Santos, Thays Domingos de Brito Rodrigues, Richardson Augusto Rosendo da Silva
Objective: To analyze the occurrence of falls in institutionalized elderly addressing the risks, consequences and antecedents. Method: Cross-sectional study carried out with 45 older adults in Long-Term Care Facilities for the Older adult in João Pessoa, Brazil, in June and July 2016. A socio-demographic questionnaire and the Berg Balance Scale were applied, classifying as risk of fall scores lower than 45. Descriptive statistics and tests were conducted: independent t-test, Anova (Tukey), Chi-square, Mann Whitney...
July 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28793077/prevalence-of-medicine-use-among-brazilian-adults-a-systematic-review
#9
Vanessa Pereira Gomes, Marcus Tolentino Silva, Taís Freire Galvão
The use of medicine in adults has been assessed by some population-based studies in Brazil, but to date there has been no overall estimate of the prevalence of drug consumption. We therefore aimed to estimate the prevalence of medicine use as measured in previously reported cross-sectional studies among Brazilian adults. We conducted a systematic review of the literature, searching in MEDLINE, Embase among others to a date ending January 2017. Two researchers selected the studies, extracted data and assessed methodological quality of those chosen for inclusion...
August 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28781116/acceleration-time-and-ratio-of-acceleration-time%C3%A2-to-ejection-time-in-aortic-stenosis-new%C3%A2-echocardiographic-diagnostic-parameters
#10
Sergio Gamaza-Chulián, Enrique Díaz-Retamino, Santiago Camacho-Freire, Dolores Ruiz-Fernández, Alejandro Gutiérrez-Barrios, Jesús Oneto-Otero
BACKGROUND: Inconsistencies between gradients and aortic valve area are frequent in the echocardiographic evaluation of aortic stenosis (AS). Assessing AS severity is essential for the correct management of the disease. The aim of this study was to evaluate whether ejection dynamics, particularly acceleration time (AT) and the ratio of AT to ejection time (ET), could be diagnostic parameters in patients with AS. METHODS: Patients with AS (aortic peak velocity > 2 m/sec) were prospectively enrolled...
August 3, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28775335/nubbedb-an-updated-database-to-uncover-chemical-and-biological-information-from-brazilian-biodiversity
#11
Alan C Pilon, Marilia Valli, Alessandra C Dametto, Meri Emili F Pinto, Rafael T Freire, Ian Castro-Gamboa, Adriano D Andricopulo, Vanderlan S Bolzani
The intrinsic value of biodiversity extends beyond species diversity, genetic heritage, ecosystem variability and ecological services, such as climate regulation, water quality, nutrient cycling and the provision of reproductive habitats it is also an inexhaustible source of molecules and products beneficial to human well-being. To uncover the chemistry of Brazilian natural products, the Nuclei of Bioassays, Ecophysiology and Biosynthesis of Natural Products Database (NuBBEDB) was created as the first natural product library from Brazilian biodiversity...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28773009/understanding-drug-release-data-through-thermodynamic-analysis
#12
Marjorie Caroline Liberato Cavalcanti Freire, Francisco Alexandrino, Henrique Rodrigues Marcelino, Paulo Henrique de Souza Picciani, Kattya Gyselle de Holanda E Silva, Julieta Genre, Anselmo Gomes de Oliveira, Eryvaldo Sócrates Tabosa do Egito
Understanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS) is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB) kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters through mathematical modeling. Film casting and electrospinning techniques were used to compare behavior of films and fibers, respectively...
June 13, 2017: Materials
https://www.readbyqxmd.com/read/28767585/pent-up-demand-for-surgery-in-the-manaus-metropolitan-region-a-population-based-cross-sectional-study
#13
Priscila Gusmão da Silva Ferreira, Tais Freire Galvao, Marcus Tolentino Silva
Waiting lines in healthcare reflect an imbalance between the availability and the demand for medical services. This study aimed to analyze the prevalence and factors associated with the pent-up demand for surgical procedures in the Manaus metropolitan region.We performed a population-based cross-sectional study in 2015. Pent-up demand was based on self-report by the participants; those who reported waiting were contacted by phone to clarify the nature and reasons for the experienced delay.We interviewed 4001 adults in their households...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28766865/trapping-as-retrieval-technique-to-resolve-a-ruptured-and-entrapped-coronary-balloon-catheter
#14
Javier León Jiménez, Jessica Roa Garrido, Santiago Jesús Camacho Freire, José Francisco Díaz Fernández
A 69 year old male, with a previous percutaneous revascularization of the mid-circumflex with a bare metal stent in 2007 was admitted to our centre for unstable angina. The angiography showed a severely calcified coronary tree with a functionally severe plaque on the proximal left anterior descending artery (LAD) and a critical focal lesion on the proximal right coronary artery. After a high pressure predilation on the proximal LAD, the balloon ruptured causing a retrograde LAD-left main (LM) dissection that was rapidly sealed with three overlapping zotarolimus-eluting stents from medial LAD to LM...
August 2, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28765595/integration-of-mirna-and-mrna-expression-profiles-reveals-microrna-regulated-networks-during-muscle-wasting-in-cardiac-cachexia
#15
Leonardo N Moraes, Geysson J Fernandez, Ivan J Vechetti-Júnior, Paula P Freire, Rodrigo W A Souza, Rolando A R Villacis, Silvia R Rogatto, Patricia P Reis, Maeli Dal-Pai-Silva, Robson F Carvalho
Cardiac cachexia (CC) is a common complication of heart failure (HF) associated with muscle wasting and poor patient prognosis. Although different mechanisms have been proposed to explain muscle wasting during CC, its pathogenesis is still not understood. Here, we described an integrative analysis between miRNA and mRNA expression profiles of muscle wasting during CC. Global gene expression profiling identified 1,281 genes and 19 miRNAs differentially expressed in muscle wasting during CC. Several of these deregulated genes are known or putative targets of the altered miRNAs, including miR-29a-3p, miR-29b-3p, miR-210-5p, miR-214, and miR-489...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28764923/association-of-rs1285933-single-nucleotide-polymorphism-in-clec5a-gene-with-dengue-severity-and-its-functional-effects
#16
Caroline Xavier-Carvalho, Renata Duarte da Silva Cezar, Naishe Matos Freire, Carla Mola, Victor Fiesta, Thiago Gomes de Toledo-Pinto, Luciana Gomes Fialho Torres, Rodrigo Feliciano do Carmo, Luydson Richardson Silva Vasconcelos, Marli Tenório Cordeiro, Paulo Baptista, Elzinandes Leal de Azeredo, Rivaldo Venâncio da Cunha, Luiz José de Souza, Antonio Guilherme Pacheco, Claire Fernandes Kubelka, Patrícia Moura, Milton Ozorio Moraes
Outbreaks of the Zika, dengue, and chikungunya viruses, especially in the Americas, pose a global threat due to their rapid spread and difficulty controlling the vector. Extreme phenotypes are often observed, from asymptomatic to severe clinical manifestations, which are well-studied in dengue. Host variations are also important contributors to disease outcomes, and many case-control studies have associated single nucleotide polymorphisms (SNPs) with severe dengue. Here, we found that the TC genotype and T-carriers for SNP rs1285933 in the C-type lectin superfamily member 5 (CLEC5A) gene was associated with severe dengue in a Northern Brazilian population (OR=2...
July 29, 2017: Human Immunology
https://www.readbyqxmd.com/read/28762656/dub3-controls-dna-damage-signalling-by-direct-deubiquitination-of-h2ax
#17
M Rocío Delgado-Díaz, Yusé Martín, Anna Berg, Raimundo Freire, Veronique A J Smits
No abstract text is available yet for this article.
August 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28755999/assessment-of-the-reliability-of-the-accelerometers-feedback-devices-depending-on-the-surface-on-which-cardiopulmonary-resuscitation-is-performed
#18
M Freire Tellado, R Navarro Patón, M P Pavón Prieto, J D Vázquez López, J Mateos Lorenzo, M A Neira Pájaro
No abstract text is available yet for this article.
July 26, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28755848/the-use-of-brazilian-propolis-for-discovery-and-development-of-novel-anti-inflammatory-drugs
#19
REVIEW
Marcelo Franchin, Irlan Almeida Freires, Josy Goldoni Lazarini, Bruno Dias Nani, Marcos Guilherme da Cunha, David Fernando Colón, Severino Matias de Alencar, Pedro Luiz Rosalen
Anti-Inflammatory drugs have been routinely used in the management of acute and chronic inflammatory conditions. Nevertheless, their undesirable side and adverse effects have encouraged the development of more selective, tolerable and efficacious drugs able to modulate the inflammatory process through distinct mechanisms than those of drugs currently available in the market, for instance, inhibition of leukocyte recruitment (chemotaxis, rolling, adhesion and transmigration). Natural products, including Brazilian propolis, have been considered a rich source of anti-inflammatory molecules due to a very complex phytochemical diversity...
June 27, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28753580/gnp-gapdh1-22-nanovaccines-prevent-neonatal-listeriosis-by-blocking-microglial-apoptosis-and-bacterial-dissemination
#20
Ricardo Calderon-Gonzalez, Elisabet Frande-Cabanes, Hector Teran-Navarro, José María Marimon, Javier Freire, David Salcines-Cuevas, M Carmen Fariñas, Claudia Gonzalez-Rico, Marco Marradi, Isabel Garcia, Mirian Alkorta-Gurrutxaga, Aida San Nicolas-Gomez, Ana Castañeda-San Pedro, Sonsoles Yañez-Diaz, Soledad Penades, Carmen Punzon, Javier Gomez-Roman, Fernando Rivera, Manuel Fresno, Carmen Alvarez-Dominguez
Clinical cases of neonatal listeriosis are associated with brain disease and fetal loss due to complications in early or late pregnancy, which suggests that microglial function is altered. This is believed to be the first study to link microglial apoptosis with neonatal listeriosis and listeriosis-associated brain disease, and to propose a new nanovaccine formulation that reverses all effects of listeriosis and confers Listeria monocytogenes (LM)-specific immunity. We examined clinical cases of neonatal listeriosis in 2013-2015 and defined two useful prognostic immune biomarkers to design listeriosis vaccines: high anti-GAPDH1-22 titres and tumor necrosis factor (TNF)/interleukin (IL)-6 ratios...
July 20, 2017: Oncotarget
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