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https://www.readbyqxmd.com/read/28432583/can-long-term-pharmacotherapy-prevent-relapses-in-generalized-anxiety-disorder-a-systematic-review
#1
REVIEW
Marina Dyskant Mochcovitch, Rafael Christophe da Rocha Freire, Rafael Ferreira Garcia, Antonio Egidio Nardi
BACKGROUND AND OBJECTIVES: Generalized anxiety disorder (GAD) is a persistent anxiety disorder with a high rate of relapse. While several trials have demonstrated the efficacy of pharmacotherapy for GAD treatment, fewer studies have investigated its efficacy in preventing symptom relapse in long-term treatment. The aim of this study is to evaluate if long-term pharmacotherapy may prevent relapses in GAD patients. METHODS: This is a systematic review of the relapse prevention trials with GAD patients...
April 21, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28432005/radial-ulnar-angioplasty-in-selected-patients-undergoing-elective-angiography-or-pci-using-complex-forearm-approach
#2
Santiago Jesús Camacho Freire, Antonio Enrique Gómez Menchero, Javier León Jiménez, Jessica Roa Garrido, Rosa Cardenal Piris, José Francisco Díaz Fernández
BACKGROUND: Angioplasty on the radial artery have been performed with good success rates in patients with critical hand ischemia. We sought to assess the feasibility and safety of radial angioplasty on complex radial access in patients undergoing coronary angiography. METHODS/MATERIAL: A prospective series of procedures with complex radial/ulnar access to which radial-ulnar angioplasty (RU-A) was performed. We set goals of efficacy and safety that included the success rate of the procedure (need for ¨Crossover femoral¨) and the existence of radial pulse at one month...
April 11, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28431946/relationship-between-calorimetric-profiles-and-differential-melting-curves-for-natural-dnas
#3
Chun-Ling Chang, Alexander S Fridman, Roger M Wartell, Chin-Kun Hu, Dmitri Y Lando
Many experiments demonstrate that regions with higher GC-content in natural DNAs unwind at higher temperatures adsorbing more heat than equivalently sized regions with lower GC-content. This simple observation implies that normalized calorimetric melting profiles (calorimetric cDMCs) will not be equivalent differential melting curves (DMCs). We propose simple expressions for long natural and random DNA sequences to reciprocally convert DMCs and corresponding calorimetric cDMCs. The expressions are confirmed by the Poland-Fixman-Freire method and an approach based upon mixtures of homopolymeric duplexes...
April 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28429495/moisture-responsive-wrinkling-surfaces-with-tunable-dynamics
#4
Songshan Zeng, Rui Li, Stephan G Freire, Vivian M M Garbellotto, Emily Y Huang, Andrew T Smith, Cong Hu, William R T Tait, Zichao Bian, Guoan Zheng, Dianyun Zhang, Luyi Sun
The wrinkle dynamics (such as reversibility and stability) of human skin are affected by the external stimuli, as well as the skin's structure and mechanical properties. Inspired by these tunable responses, three types of moisture-responsive wrinkle dynamics are achieved, for the first time, through a single film-substrate system. These dynamics include: (1) completely reversible wrinkles formation; (2) irreversible wrinkles formation I: the initially formed wrinkles can be permanently erased and never reappear; and (3) irreversible wrinkles formation II: once the wrinkles form, they can no longer be erased...
April 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28428951/the-effect-of-flour-from-the-rind-of-the-yellow-passion-fruit-on-glycemic-control-of-people-with-diabetes-mellitus-type-2-a-randomized-clinical-trial
#5
Márcio Flávio Moura de Araújo, Vivian Saraiva Veras, Roberto Wagner Júnior Freire de Freitas, Maria do Livramento de Paula, Thiago Moura de Araújo, Lilian Raquel Alexandre Uchôa, Maria Wendiane Gueiros Gaspar, Maria da Conceição do Santos Oliveira Cunha, Maria Aparecida Alves de Oliveira Serra, Carolina Maria de Lima Carvalho, Edmara Chaves Costa, Marta Maria Coelho Damasceno
BACKGROUND: The single or combined use of herbal and dietary products with medications has shown benefits in the metabolic modulation of carbohydrates, in the restoring of the function of pancreatic beta cells, and in insulin resistance. To analyze the effect of the use of flour made from the rind of the yellow passion fruit on the glycemic control of people with diabetes mellitus type 2. METHODS: An open, prospective, randomized clinical trial was undertaken with 54 participants over an eight-week period...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28424664/spotted-fever-epidemiology-and-vector-rickettsia-host-relationship-in-rio-de-janeiro-state
#6
Diego C Montenegro, Karla Bitencourth, Stefan V de Oliveira, Ana P Borsoi, Karen M Cardoso, Maria S B Sousa, Cristina Giordano-Dias, Marinete Amorim, Nicolau M Serra-Freire, Gilberto S Gazêta, Reginaldo P Brazil
The eco-epidemiological scenario of spotted fever (SF), a tick-borne disease that affects humans and other animals in several countries around the world, was analyzed in Rio de Janeiro (RJ) State, Brazil. During the last 34 years, 990 SF cases were reported in RJ (the Brazilian state with the highest population density), including 116 cases confirmed by serology (RIFI) or PCR, among 42.39% of the municipalities with reported cases of SF. The epidemiologic dynamics of SF in RJ State are very heterogeneous in time and space, with outbreaks, high mortality rates and periods of epidemiological silence (no SF cases reported)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28423824/querying-archetype-based-electronic-health-records-using-hadoop-and-dewey-encoding-of-openehr-models
#7
Erik Sundvall, Fang Wei-Kleiner, Sergio M Freire, Patrick Lambrix
Archetype-based Electronic Health Record (EHR) systems using generic reference models from e.g. openEHR, ISO 13606 or CIMI should be easy to update and reconfigure with new types (or versions) of data models or entries, ideally with very limited programming or manual database tweaking. Exploratory research (e.g. epidemiology) leading to ad-hoc querying on a population-wide scale can be a challenge in such environments. This publication describes implementation and test of an archetype-aware Dewey encoding optimization that can be used to produce such systems in environments supporting relational operations, e...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423122/development-and-validation-of-a-stratification-tool-for-predicting-risk-of-deep-sternal-wound-infection-after-coronary-artery-bypass-grafting-at-a-brazilian-hospital
#8
Michel Pompeu Barros Oliveira Sá, Paulo Ernando Ferraz, Artur Freire Soares, Rodrigo Gusmão Albuquerque Miranda, Mayara Lopes Araújo, Frederico Vasconcelos Silva, Ricardo de Carvalho Lima
Objective: Deep sternal wound infection following coronary artery bypass grafting is a serious complication associated with significant morbidity and mortality. Despite the substantial impact of deep sternal wound infection, there is a lack of specific risk stratification tools to predict this complication after coronary artery bypass grafting. This study was undertaken to develop a specific prognostic scoring system for the development of deep sternal wound infection that could risk-stratify patients undergoing coronary artery bypass grafting and be applied right after the surgical procedure...
January 2017: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28423119/importance-of-serca2a-on-early-isolated-diastolic-dysfunction-induced-by-supravalvular-aortic-stenosis-in-rats
#9
C F S M P Silveira, D H S Campos, P P Freire, A F Deus, K Okoshi, C R Padovani, A C Cicogna
Cardiac remodeling is defined as changes in shape and function of the heart in response to aggression (pressure overload). The sarcoplasmic reticulum calcium ATPase cardiac isoform 2a (SERCA2a) is a known factor that influences function. A wide spectrum of studies report a decrease in SERCA2a in heart failure, but none evaluate it's the role in early isolated diastolic dysfunction in supravalvular aortic stenosis (AoS). Our hypothesis was that SERCA2a participates in such dysfunction. Thirty-day-old male Wistar rats (60-80 g) were divided into AoS and Sham groups, which were submitted to surgery with or without aorta clipping, respectively...
April 13, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28418699/candida-endocarditis-presenting-as-acute-myocardial-infarction
#10
Anirudh Aron, Upasna Manchanda-Aron, Amado X Freire
No abstract text is available yet for this article.
April 18, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28414935/cdna-cloning-molecular-modeling-and-docking-calculations-of-l-type-lectins-from-swartzia-simplex-var-grandiflora-leguminosae-papilionoideae-a-member-of-the-tribe-swartzieae
#11
Paulo A C Maranhão, Claudener S Teixeira, Bruno L Sousa, Ito L Barroso-Neto, José E Monteiro-Júnior, Andreia V Fernandes, Marcio V Ramos, Ilka M Vasconcelos, José F C Gonçalves, Bruno A M Rocha, Valder N Freire, Thalles B Grangeiro
The genus Swartzia is a member of the tribe Swartzieae, whose genera constitute the living descendants of one of the early branches of the papilionoid legumes. Legume lectins comprise one of the main families of structurally and evolutionarily related carbohydrate-binding proteins of plant origin. However, these proteins have been poorly investigated in Swartzia and to date, only the lectin from S. laevicarpa seeds (SLL) has been purified. Moreover, no sequence information is known from lectins of any member of the tribe Swartzieae...
April 14, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28414176/genome-specific-ppar%C3%AE-b-duplicates-in-salmonids-and-insights-into-estrogenic-regulation-in-brown-trout
#12
Tânia Vieira Madureira, Ivone Pinheiro, Rafaelle de Paula Freire, Eduardo Rocha, Luis Filipe Castro, Ralph Urbatzka
Peroxisome proliferator-activated receptors (PPAR) are key regulators of many processes in vertebrates, such as carbohydrate and lipid metabolism. PPARα, a member of the PPAR nuclear receptor gene subfamily (NR1C1), is involved in fatty acid metabolism, namely in peroxisomal β-oxidation. Two gene paralogues, pparαA and pparαB, were described in several teleost species with their origin dating back to the teleost-specific genome duplication (3R). Given the additional salmonid-specific genome duplication (4R), four genes could be theoretically anticipated for this gene subfamily...
April 14, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28413656/effect-of-ki-67-assessment-in-the-distribution-of-breast-cancer-subtypes-evaluation-in-a-cohort-of-latin-american-patients
#13
Alejandro Yábar, Rosa Meléndez, Silvia Muñoz, Hugo Deneo, Jimena Freire, Viviana Domínguez, Roberto M Carrasco-Navarro, Maria E Diaz, Raúl E Velarde-López
Breast cancer (BC) is a heterogeneous disease composed of four main subtypes with distinct clinical and epidemiological features. Although several reports have described the distribution of BC subtypes in Latin America, the majority of them have not included the cellular marker, Ki-67, in the immunohistochemical (IHC) panel. The aim of the present study was to describe the distribution of BC subtypes in a cohort of Latin American women using an IHC panel with Ki-67. A prospective cohort of 580 patients in three centers of Peru (the Hospital Nacional Edgardo Rebagliatti Martins, the Hospital Nacional Guillermo Almenara Irigoyen, the Hospital Nacional Alberto Sabogal, Lima) and one in Uruguay (Instituto Nacional del Cáncer, Montevideo) were evaluated...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28410472/histological-alterations-in-gills-of-macrobrachium-amazonicum-juveniles-exposed-to-ammonia-and-nitrite
#14
Fabrício Martins Dutra, Milton Rönnau, Dircelei Sponchiado, Sandra Carla Forneck, Carolina Arruda Freire, Eduardo Luis Cupertino Ballester
Aquaculture has shown great growth in the last decades. Due to the restrictions on water use, production systems are becoming increasingly more intensive, raising concerns about the production water quality. Macrobrachium amazonicum is among the freshwater prawn species with favorable characteristics for production and possibility of intensification. Nitrogen compounds such as ammonia and nitrite affect the health of aquatic organisms since they quickly reach toxic concentrations. These compounds can also cause damage to the gill structure, leading to hypoxia in tissues, affecting acid-base balance, osmoregulation (salt absorption) and ammonia excretion, decreasing the immune capacity of the animal and, in extreme cases, cause death...
April 8, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28405644/alternative-probe-for-the-determination-of-the-hydrogen-bond-acidity-of-ionic-liquids-and-their-aqueous-solutions
#15
Pedro P Madeira, Helena Passos, Joana Gomes, João A P Coutinho, Mara G Freire
Although highly relevant to a priori select adequate solvents for a given application, the determination of the hydrogen-bond acidity or proton donor ability of aqueous solutions of ionic liquids is a difficult task due to the poor solubility of the commonly used probes in aqueous media. In this work, we demonstrate the applicability of the pyridine-N-oxide probe to determine the hydrogen-bond acidity of both neat ionic liquids and their aqueous solutions, based on (13)C NMR chemical shifts, and the suitability of these values to appraise the ability of ionic liquids to form aqueous two-phase systems...
April 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28404450/does-lying-in-the-recovery-position-increase-the-likelihood-of-not-delivering-cardiopulmonary-resuscitation
#16
Miguel Freire-Tellado, Rubén Navarro-Patón, Maria Del Pilar Pavón-Prieto, Marta Fernández-López, Javier Mateos-Lorenzo, Ivan López-Fórneas
BACKGROUND: Resuscitation guidelines endorse unconscious and normally breathing out-of-hospital victims to be placed in the recovery position to secure airway patency, but recently a debate has been opened as to whether the recovery position threatens the cardiac arrest victim's safety assessment and delays the start of cardiopulmonary resuscitation. AIM: To compare the assessment of the victim's breathing arrest while placed in the recovery position versus maintaining an open airway with the continuous head tilt and chin lift technique to know whether the recovery position delays the cardiac arrest victim's assessment and the start of cardiopulmonary resuscitation...
April 9, 2017: Resuscitation
https://www.readbyqxmd.com/read/28403313/educational-action-research-on-facebook%C3%A2-combining-leisure-and-learning
#17
Célia Maria Gomes Labegalini, Iara Sescon Nogueira, Daysi Mara Murio Ribeiro Rodrigues, Elton Carlos Almeida, Sonia Maria Villela Bueno, Vanessa Denardi Antoniassi Baldissera
Objective: To analyse the path of dialogical education in leisure and mental health in social media. Method: Action research based on the theoretical-methodological framework of Paulo Freire, conducted with 11 nursing students of a public university in the state of Paraná, Brazil, during seven days of June 2015, in a closed group on Facebook®. The dialogues were called, 'Virtual Culture Circles' and preceded by self-administered questionnaires that addressed the relationship between leisure and mental health...
April 6, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28403300/multi-professional-team-s-perception-of-nurses-competences-in-liver-transplantations
#18
Francisca Diana da Silva Negreiros, Alice Maria Correia Pequeno, José Huygens Parente Garcia, Maria Isis Freire de Aguiar, Tatiana Rebouças Moreira, Maria José Nascimento Flor
Objective describe the multi-professional team's perception of nurses' competences in liver transplantation programs. METHOD: descriptive study with a qualitative approach. Data were collected through a questionnaire. Participants were 12 professionals of the liver transplantation team of a reference hospital. For result interpretation, the thematic analysis technique was employed. RESULTS: the professionals assessed the competences employed by nurses as proactive, autonomous, creative, humanized, capable of teamwork, decision-making and conflict management...
April 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28403288/prevalence-of-metabolic-syndrome-in-individuals-with-type-2-diabetes-mellitus
#19
José Cláudio Garcia Lira Neto, Mayra de Almeida Xavier, José Wicto Pereira Borges, Márcio Flávio Moura de Araújo, Marta Maria Coelho Damasceno, Roberto Wagner Júnior Freire de Freitas
OBJECTIVE: to identify the prevalence of Metabolic Syndrome and its components in a population of patients with type 2 Diabetes Mellitus. METHOD: a cross-sectional study was conducted with 201 diabetic patients. A descriptive analysis and Chi-square and Fisher's exact tests ( p <0.05) were performed. RESULTS: the majority of participants were females and overweight, with a mean age of 63.1 years and a low level of education, and categorized as physically inactive...
April 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28403147/cryptosporidium-spp-and-giardia-spp-in-feces-and-water-and-the-associated-exposure-factors-on-dairy-farms
#20
Roberta Dos Santos Toledo, Felippe Danyel Cardoso Martins, Fernanda Pinto Ferreira, Jonatas Campos de Almeida, Liza Ogawa, Hannah Lia Ettiene Peruch Lemos Dos Santos, Maíra Moreira Dos Santos, Filipe Aguera Pinheiro, Italmar Teodorico Navarro, João Luis Garcia, Roberta Lemos Freire
The aims of this study were to verify the prevalence of Cryptosporidium spp. and Giardia spp. in animal feces and drinking water on dairy farms and to identify a possible relation between the exposure factors and the presence of these parasites. Fecal samples from cattle and humans and water samples were collected on dairy farms in Paraná, Brazil. Analysis of (oo)cysts in the feces was performed by the modified Ziehl-Neelsen staining and centrifugal flotation in zinc sulfate. Test-positive samples were subjected to nested PCR amplification of the 18SSU ribosomal RNA gene for identification of Cryptosporidium and Giardia and of the gp60 gene for subtyping of Cryptosporidium...
2017: PloS One
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