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https://www.readbyqxmd.com/read/28733614/raman-evidence-for-pressure-induced-formation-of-diamondene
#1
Luiz Gustavo Pimenta Martins, Matheus J S Matos, Alexandre R Paschoal, Paulo T C Freire, Nadia F Andrade, Acrísio L Aguiar, Jing Kong, Bernardo R A Neves, Alan B de Oliveira, Mário S C Mazzoni, Antonio G Souza Filho, Luiz Gustavo Cançado
Despite the advanced stage of diamond thin-film technology, with applications ranging from superconductivity to biosensing, the realization of a stable and atomically thick two-dimensional diamond material, named here as diamondene, is still forthcoming. Adding to the outstanding properties of its bulk and thin-film counterparts, diamondene is predicted to be a ferromagnetic semiconductor with spin polarized bands. Here, we provide spectroscopic evidence for the formation of diamondene by performing Raman spectroscopy of double-layer graphene under high pressure...
July 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28732033/spatial-and-simultaneous-representative-seroprevalence-of-anti-toxoplasma-gondii-antibodies-in-owners-and-their-domiciled-dogs-in-a-major-city-of-southern-brazil
#2
Aline do Nascimento Benitez, Felippe Danyel Cardoso Martins, Marcelle Mareze, Nelson Jessé Rodrigues Santos, Fernanda Pinto Ferreira, Camila Marinelli Martins, João Luis Garcia, Regina Mitsuka-Breganó, Roberta Lemos Freire, Alexander Welker Biondo, Italmar Teodorico Navarro
Toxoplasmosis, caused by Toxoplasma gondii, has traditionally been considered an important water and foodborne protozoonosis with important public health considerations. Although felids play a well-established role as definitive hosts, canine epidemiological involvement in the parasite's life cycle remains questionable and controversial. The increasing closeness of the human-dog bond, particularly seen in urban settings, has been recognized as a historically unprecedented worldwide movement. Sharing daily lives in the same households, dogs may be exposed to similar associated risks of T...
2017: PloS One
https://www.readbyqxmd.com/read/28729162/effect-of-3basic-life-support-training-programs-in-future-primary-school-teachers-a-quasi-experimental-design
#3
R Navarro-Patón, M Freire-Tellado, S Basanta-Camiño, R Barcala-Furelos, V Arufe-Giraldez, J E Rodriguez-Fernández
AIM: To evaluate the learning of basic life support (BLS) measures on the part of laypersons after 3different teaching programs. DESIGN: A quasi-experimental before-after study involving a non-probabilistic sample without a control group was carried out. SCOPE: Primary school teacher students from the University of Santiago (Spain). PARTICIPANTS: A total of 124 students (68.8% women and 31.2% men) aged 20-39 years (M=22...
July 17, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28726269/previous-physical-exercise-alters-hepatic-profile-of-oxidative-inflammatory-status-and-limits-the-secondary-brain-damage-induced-by-severe-tbi-in-rats
#4
Mauro Robson Torres de Castro, Ana Paula de Oliveira Ferreira, Guilherme Lago Busanello, Luís Roberto Hart da Silva, Mauro Eduardo Porto da Silveira Junior, Fernando Fiorin, Gabriela Arrifano, Maria Elena Crespo López, Rômulo Pillon Barcelos, María J Cuevas, Guilherme Bresciani, Javier González-Gallego, Michele Rechia Fighera, Luiz Fernando Freire Royes
Although systemic responses have been described after traumatic brain injury (TBI), little is known regarding potential interactions between brain and peripheral organs after neuronal injury. In this sense, we decided to investigate whether peripheral oxidative/inflammatory response contributes to the neuronal dysfunction after TBI as well as prophylactic role of exercise training. Animals were submitted to fluid percussion injury (FPI) after 6 weeks of swimming training. Previous exercise training increased mRNA expression of X receptor alpha (LXR-α), ATP-binding cassette transporter (ABCA1), and decreased inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-α) and interleukin (IL)-6 expression per se in liver...
July 20, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28722205/temperature-stability-of-proteins-analysis-of-irreversible-denaturation-using-isothermal-calorimetry
#5
Arne Schön, Benjamin R Clarkson, Maria Jaime, Ernesto Freire
The structural stability of proteins has been traditionally studied under conditions in which the folding/unfolding reaction is reversible, since thermodynamic parameters can only be determined under these conditions. Achieving reversibility conditions in temperature stability experiments has often required performing the experiments at acidic pH or other non-physiological solvent conditions. With the rapid development of protein drugs, the fastest growing segment in the pharmaceutical industry, the need to evaluate protein stability under formulation conditions has acquired renewed urgency...
July 19, 2017: Proteins
https://www.readbyqxmd.com/read/28715017/multipodal-dynamic-coordination-involving-cation-%C3%AF-interactions-to-control-the-structure-of-helical-polymers
#6
Mohammad Alzubi, Sandra Arias, Iria Louzao, Emilio Quiñoá, Ricardo Riguera, Félix Freire
A precise tuning of the four possible states of a helix (P/M helical sense and stretched/compressed helical backbone) is attained by controlling the complexation between Li(+) and a poly(phenylacetylene) that bears amide, ester and phenyl ring functionalities at the pendant group. Depending on the MeOH ratio that is present as a cosolvent, different coordination sites are involved in interactions leading to complexes I-III, each one with a characteristic structure (tri-, bi-, and unipodal) and an associated helical state...
July 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28714508/gold-glyconanoparticles-coupled-to-listeriolysin-o-91-99-peptide-serve-as-adjuvant-therapy-against-melanoma
#7
R Calderon-Gonzalez, H Terán-Navarro, I García, M Marradi, D Salcines-Cuevas, S Yañez-Diaz, A Solis-Angulo, E Frande-Cabanes, M C Fariñas, A Garcia-Castaño, J Gomez-Roman, S Penades, F Rivera, J Freire, C Álvarez-Domínguez
Dendritic cell-based (DC-based) vaccines are promising immunotherapies for cancer. However, several factors, such as the lack of efficient targeted delivery and the sources and types of DCs, have limited the efficacy of DCs and their clinical potential. We propose an alternative nanotechnology-based vaccine platform with antibacterial prophylactic abilities that uses gold glyconanoparticles coupled to listeriolysin O 91-99 peptide (GNP-LLO91-99), which acts as a novel adjuvant for cancer therapy. GNP-LLO91-99, when used to vaccinate mice, exhibited dual antitumour activities, namely, the inhibition of tumour migration and growth and adjuvant activity for recruiting and activating DCs, including those from melanoma patients...
July 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28713192/foxp3-allelic-variants-and-haplotype-structures-are-associated-with-aggressive-breast-cancer-subtypes
#8
Bruna Karina Banin Hirata, Roberta Losi Guembarovski, Glauco Akelinghton Freire Vitiello, Alda Losi Guembarovski, Karen Brajão de Oliveira, Maria Angelica Ehara Watanabe
FOXP3 genetic polymorphisms have been associated with cancer development and prognosis. In this context, the present study aimed to evaluate the g.10403A>G (rs2232365) polymorphisms and g.8048A>C (rs3761548), in aggressive breast cancer (BC) subtypes, including, Luminal B HER2+ (LB), HER2-enriched (HER2+), and triple-negative (TN). Polymerase chain reaction followed by enzymatic restriction was performed to genotyping 117 BC samples and 300 controls. A significant association of AA genotype (g.10403A>G) in relation to BC susceptibility (OR = 1...
2017: Disease Markers
https://www.readbyqxmd.com/read/28712894/antimicrobial-and-immunomodulatory-activity-of-host-defense-peptides-clavanins-and-ll-37-in-vitro-an-endodontic-perspective
#9
Stella Maris F Lima, Mirna S Freire, Ana Luisa O Gomes, Ana Paula C Cantuária, Flávia Rodrigues P Dutra, Beatriz S Magalhães, Maurício Gonçalves C Sousa, Ludovico Migliolo, Jeeser A Almeida, Octávio L Franco, Taia Maria B Rezende
Endodontic treatment is mainly based on root canal disinfection and its failure may be motivated by microbial resistance. Endodontic therapy can be benefitted by host defense peptides (HDPs), which are multifunctional molecules that act against persistent infection and inflammation. This study aimed to evaluate the antimicrobial, cytotoxic and immunomodulatory activity of several HDPs, namely clavanin A, clavanin A modified (MO) and LL-37, compared to intracanal medication Ca(OH)2. HDPs and Ca(OH)2 were evaluated by: (1) antimicrobial assays against Candida albicans and Enterococcus faecalis, (2) cytotoxicity assays and (3) cytokine tumor necrosis factor (TNF)-α, monocyte chemoattractant protein (MCP)-1, interleukin (IL)-1α, IL-6, IL-10 and IL-12 and nitric oxide (NO) production by RAW 264...
July 14, 2017: Peptides
https://www.readbyqxmd.com/read/28711791/labeled-azospirillum-brasilense-wild-type-and-excretion-ammonium-strains-in-association-with-barley-roots
#10
Adrian Richard Schenberger Santos, Rafael Mazer Etto, Rafaela Wiegand Furmam, Denis Leandro de Freitas, Karina Freire d'Eça Nogueira Santos, Emanuel Maltempi de Souza, Fábio de Oliveira Pedrosa, Ricardo Antônio Ayub, Maria Berenice Reynaud Steffens, Carolina Weigert Galvão
Soil bacteria colonization in plants is a complex process, which involves interaction between many bacterial characters and plant responses. In this work, we labeled Azospirillum brasilense FP2 (wild type) and HM053 (excretion-ammonium) strains by insertion of the reporter gene gusA-kanamycin into the dinitrogenase reductase coding gene, nifH, and evaluated bacteria colonization in barley (Hordeum vulgare). In addition, we determined inoculation effect based on growth promotion parameters. We report an uncommon endophytic behavior of A...
July 4, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28710358/latitudinal-cline-of-chronotype
#11
Mario André Leocadio-Miguel, Fernando Mazzili Louzada, Leandro Lourenção Duarte, Roberta Peixoto Areas, Marilene Alam, Marcelo Ventura Freire, John Fontenele-Araujo, Luiz Menna-Barreto, Mario Pedrazzoli
The rotation of the Earth around its own axis and around the sun determines the characteristics of the light/dark cycle, the most stable and ancient 24 h temporal cue for all organisms. Due to the tilt in the earth's axis in relation to the plane of the earth's orbit around the sun, sunlight reaches the Earth differentially depending on the latitude. The timing of circadian rhythms varies among individuals of a given population and biological and environmental factors underlie this variability. In the present study, we tested the hypothesis that latitude is associated to the regulation of circadian rhythm in humans...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710192/organ-sparing-surgery-for-large-cell-calcifying-sertoli-cell-tumour-in-a-patient-with-carney-complex
#12
Maria José Freire, Pedro Nunes, Luà S Sousa, Arnaldo Figueiredo
Carney complex is a rare genetic disease characterised by a complex of myxomas, spotty pigmentation and endocrine overactivity. At diagnosis, about one-third of male patients presents with testicular tumours, namely large cell calcifying Sertoli cell tumours, which are often multicentric and/or bilateral and have a low malignant potential. Although radical orchiectomy is the gold standard for the treatment of testicular neoplasms, a conservative approach with partial orchiectomy or tumourectomy may be the best treatment option for these patients, allowing the preservation of endocrine function, fertility and body image...
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28705677/hyicin-4244-the-first-sactibiotic-described-in-staphylococci-exhibits-an-anti-staphylococcal-biofilm-activity
#13
Andreza Freitas de Souza Duarte, Hilana Ceotto-Vigoder, Emile Santos Barrias, Thaïs Cristina Baeta Soares Souto-Padrón, Ingolf Figved Nes, Maria do Carmo de Freire Bastos
Hyicin 4244 is a small antimicrobial peptide with a broad-spectrum of activity found in the culture supernatant of Staphylococcus hyicus 4244, whose genome was then sequenced. The bacteriocin gene cluster (hyiSABCDEFG) was mined from its single chromosome and exhibited a genetic organization similar to that of subtilosin A. All genes involved in hyicin 4244 biosynthesis proved to be transcribed and encode proteins that share at least 42 % similarity to proteins encoded by the subtilosin A gene cluster. Due to its resemblance to subtilosin A and the presence of three thioether bonds in its structure, hyicin 4244 is assumed to be a 35 amino acid circular sactibiotic, the first to be described in staphylococci...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28704561/diet-overlap-and-spatial-segregation-between-two-neotropical-marsupials-revealed-by-multiple-analytical-approaches
#14
Vanessa Villanova Kuhnen, Gustavo Quevedo Romero, Arício Xavier Linhares, Jeferson Vizentin-Bugoni, Erica Aline Correa Porto, Eleonore Zulnara Freire Setz
Species co-existence depends on how organisms utilize their environment and resources. When two sympatric species are similar in some ecological requirements, their coexistence may arise from differences in resource use over time and/or space. Interactions among coexisting marsupials remain poorly understood, especially in the Neotropics. Here we combine spatial niche measurements, individual-resource networks, and isotopic niche approaches, to investigate the ecological strategies used by the Neotropical marsupials Didelphis aurita and Metachirus nudicaudatus to co-occur in an area of Serra do Mar State Park (southeast of Brazil)...
2017: PloS One
https://www.readbyqxmd.com/read/28702457/multiple-myeloma-cells-express-key-immunoregulatory-cytokines-and-modulate-the-monocyte-migratory-response
#15
Leonardo Freire-de-Lima, Ana Flávia Fernandes Ribas Nardy, Erivan Schnaider Ramos-Junior, Luciana Conde, Jéssica Santos Lemos, Leonardo Marques da Fonseca, Juliana Echevarria Lima, Angelo Maiolino, Alexandre Morrot
Multiple myeloma (MM) is a plasma cell disorder that still remains incurable. The immune dysfunction of the host is a striking characteristic of MM, leading to tumor growth and reducing the survival rate of patients. Monocytes are precursors of conventional dendritic cells (DCs), a major player in the immunity mechanisms driving protective T cell responses against tumor. Herein, we report that human MM RPMI 8226 cell line shows a pronounced chemoattractant activity for monocytes and also expresses enhanced levels of the leukocyte chemotactic cytokines CXCL12, CCL5, MIP-1β, and CXCL10 in association with elevated levels of both key immunoregulatory interleukins such as IL-4 and IL-10...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28694092/deep-infiltrating-endometriosis-urinary-tract-involvement-and-predictive-factors-for-major-surgery
#16
Maria José Freire, Paulo Jorge Dinis, Rita Medeiros, Luís Sousa, Fernanda Águas, Arnaldo Figueiredo
OBJECTIVES: To evaluate urinary tract involvement by deep infiltrating endometriosis (DIE) as well as the surgical treatment and existence of predictive factors for major urologic surgery. METHODS: Retrospective analysis of 656 women submitted to surgery for endometriosis, of which 28 patients underwent minor or major surgery for DIE involving the urinary tract, with a mean age of 38 ± 6.9 years (27-50) at diagnosis. Clinical data, surgeries performed and complications were analysed...
July 7, 2017: Urology
https://www.readbyqxmd.com/read/28693553/interaction-between-saliva-s-adenosine-and-tick-parasitism-effects-on-feeding-and-reproduction
#17
Elen Anatriello, Carlo José Freire Oliveira, Nathália Baptista Oliveira, Andressa Fisch, Cristiane Maria Milanezi, João Santana da Silva, Isabel Kinney Ferreira de Miranda-Santos, Beatriz Rossetti Ferreira
BACKGROUND: It has recently been demonstrated that saliva from Rhipicephalus sanguineus ticks contains adenosine (ADO) and prostaglandin E2 (PGE2), two non-protein molecules that have significant immunomodulatory properties. These molecules can inhibit cytokine production by dendritic cells (DCs), while also reducing the expression of CD40 in these cells. However, more studies are needed for a better understanding of their participation in the feeding of ticks in vivo. This work, therefore, evaluated the importance of ADO during tick infestations...
July 10, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28691915/forensic-individual-age-estimation-with-dna-from-initial-approaches-to-methylation-tests
#18
REVIEW
A Freire-Aradas, C Phillips, M V Lareu
Individual age estimation is a key factor in forensic science analysis that can provide very useful information applicable to criminal, legal, and anthropological investigations. Forensic age inference was initially based on morphological inspection or radiography and only later began to adopt molecular approaches. However, a lack of accuracy or technical problems hampered the introduction of these DNA-based methodologies in casework analysis. A turning point occurred when the epigenetic signature of DNA methylation was observed to gradually change during an individual´s lifespan...
July 2017: Forensic Science Review
https://www.readbyqxmd.com/read/28683515/profile-of-reproductive-issues-associated-with-different-sickle-cell-disease-genotypes
#19
Flávia Anchielle Carvalho, Ariani Impieri Souza, Ana Laura Carneiro Gomes Ferreira, Simone da Silva Neto, Ana Carolina Pessoa de Lima Oliveira, Maria Luiza Rodrigues Pinheiro Gomes, Manuela Freire Hazin Costa
Purpose To describe the reproductive variables associated with different sickle cell disease (SCD) genotypes and the influence of contraceptive methods on acute painful episodes among the women with the homozygous hemoglobin S (HbSS) genotype. Methods A cross-sectional study was conducted between September of 2015 and April of 2016 on 158 women afflicted with SCD admitted to a hematology center in the Northeast of Brazil. The reproduction-associated variables of different SCD genotypes were assessed using the analysis of variance (ANOVA) test to compare means, and the Kruskal-Wallis test to compare medians...
July 6, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28682933/acute-capsaicin-supplementation-improves-resistance-training-performance-in-trained-men
#20
Marcelo Conrado de Freitas, Jason M Cholewa, Renan Valero Freire, Bruna Alves Carmo, Jefferson Bottan, Murilo Bratfich, Murilo Portari Della Bandeira, Daniela Caetano Gonçalves, Erico Chagas Caperuto, Fabio S Lira, Fabrício E Rossi
The purpose of this study was to investigate the acute effect of capsaicin supplementation on performance, rate of perceived exertion and blood lactate concentrations during resistance exercise in healthy trained young men. Ten resistance-trained men (age= 22.7±4.0 yrs, weight= 82.3±9.6 kg, height= 1.75±0.1 cm) completed two randomized, double-blind trials: Capsaicin condition (12mg) or a placebo condition. Forty five minutes after supplement consumption, subjects performed four sets until movement failure in the squat exercise at 70% of 1RM with 90 seconds of rest interval between sets...
July 3, 2017: Journal of Strength and Conditioning Research
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