keyword
MENU ▼
Read by QxMD icon Read
search

Triptorelin test

keyword
https://www.readbyqxmd.com/read/27829826/evaluate-the-effectiveness-of-conservative-treatment-for-menorrhagia-in-women-who-were-admitted-to-the-shahid-sadoughi-hospital-of-yazd-iran-in-2014-2015
#1
M Karimi-Zarchi, M Zaid Abadinezhad, B Bonyadpour, S Kabyrpour-Ashkezar, A M Abhaji
BACKGROUND AND AIM: Abnormal uterine bleeding is one of the most common debilitating menstrual problems. The first therapeutic strategy for abnormal uterine bleeding is drug treatment. This study was, therefore, designed to determine the efficacy of megestrol, medroxyprogesterone, GnRh agonist, Levonorgestrol IUD and endometrial ablation on bleeding and also to evaluate the side effects of each methods in patients with menorrhagia who were admitted to the Shahid Sadoughi clinic of Yazd University of Medical Sciences...
September 2016: International Journal of Biomedical Science: IJBS
https://www.readbyqxmd.com/read/27603324/a-6-month-trial-of-the-efficacy-and-safety-of-triptorelin-pamoate-11-25-mg-every-3-months-in-children-with-precocious-puberty-a-retrospective-comparison-with-triptorelin-acetate
#2
Delphine Zenaty, Joelle Blumberg, Nilani Liyanage, Evelyne Jacqz-Aigrain, Najiba Lahlou, Jean-Claude Carel
BACKGROUND/AIMS: To evaluate the efficacy and safety of a triptorelin pamoate (11.25 mg) 3-month formulation in the management of central precocious puberty (CPP) (TP Study) and to retrospectively compare it with a triptorelin acetate (11.25 mg) 3-month formulation (TA Study). METHODS: We conducted two phase III, multicentre, single-stage, non-comparative, open-label studies. In the TP Study, patients with CPP received an intramuscular injection of triptorelin pamoate 11...
September 7, 2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27462292/cognitive-emotional-and-psychosocial-functioning-of-girls-treated-with-pharmacological-puberty-blockage-for-idiopathic-central-precocious-puberty
#3
Slawomir Wojniusz, Nina Callens, Stefan Sütterlin, Stein Andersson, Jean De Schepper, Inge Gies, Jesse Vanbesien, Kathleen De Waele, Sara Van Aken, Margarita Craen, Claus Vögele, Martine Cools, Ira R Haraldsen
Central precocious puberty (CPP) develops due to premature activation of the hypothalamic-pituitary-gonadal (HPG) axis, resulting in early pubertal changes and rapid bone maturation. CPP is associated with lower adult height and increased risk for development of psychological problems. Standard treatment of CPP is based on postponement of pubertal development by blockade of the HPG axis with gonadotropin releasing hormone analogs (GnRHa) leading to abolition of gonadal sex hormones synthesis. Whereas the hormonal and auxological effects of GnRHa are well-researched, there is a lack of knowledge whether GnRHa treatment influences psychological functioning of treated children, despite the fact that prevention of psychological problems is used as one of the main reasons for treatment initiation...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27348542/effect-of-mid-luteal-phase-gnrh-agonist-on-frozen-thawed-embryo-transfers-during-natural-menstrual-cycles-a-randomised-clinical-pilot-study
#4
Jaana Seikkula, Leena Anttila, Päivi Polo-Kantola, Risto Bloigu, Janne Engblom, Helena Tinkanen, Varpu Jokimaa
This prospective randomised crossover study evaluated the effect of mid-luteal single-dose gonadotropin-releasing hormone agonist (triptoreline) on pregnancy outcomes in natural-cycle frozen embryo transfers (FETs). Ninety-eight women were randomised to receive either standard luteal support with vaginal micronised progesterone or an additional single dose of 0.1 mg triptoreline at the time of implantation. The intervention group was composed of 65 FET cycles and the control group of 62 cycles. In the intervention group, there were more positive pregnancy tests, clinical pregnancies and live births, but the differences did not reach statistical significance...
June 27, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27191050/central-precocious-puberty-revisiting-the-diagnosis-and-therapeutic-management
#5
Vinícius Nahime Brito, Angela Maria Spinola-Castro, Cristiane Kochi, Cristiane Kopacek, Paulo César Alves da Silva, Gil Guerra-Júnior
Clinical and laboratory diagnosis and treatment of central precocious puberty (CPP) remain challenging due to lack of standardization. The aim of this revision was to address the diagnostic and therapeutic features of CPP in Brazil based on relevant international literature and availability of the existing therapies in the country. The diagnosis of CPP is based mainly on clinical and biochemical parameters, and a period of follow-up is desirable to define the "progressive" form of sexual precocity. This occurs due to the broad spectrum of pubertal development, including isolated premature thelarche, constitutional growth and puberty acceleration, progressive and nonprogressive CPP, and early puberty...
April 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27083468/development-of-a-68-ga-peptide-tracer-for-pet-gnrh1-imaging
#6
Masoumeh Zoghi, Amir R Jalilian, Ali Niazi, Fariba Johari-Daha, Behrouz Alirezapour, Saeed Ramezanpour
OBJECTIVE: Total synthesis, quality control and preclinical evaluation of [(68)Ga]-DOTA-triptorelin ([(68)Ga]-DOTA-TRP) is reported as a possible PET radiotracer for GnRH receptor imaging. METHODS: DOTA-TRP was totally synthesized in two steps and after characterization went through radiolabelling optimization studies followed by tracer stability. The biodistribution of the tracer in normal male rats and 4T1 tumour-bearing mice was performed in 120 min after i...
July 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/26675317/assessment-of-estradiol-response-after-depot-triptorelin-administration-in-girls-with-central-precocious-puberty
#7
Analía Verónica Freire, Mirta Graciela Gryngarten, María Gabriela Ballerini, Andrea Josefina Arcari, María Eugenia Escobar, Ignacio Bergadá, María Gabriela Ropelato
BACKGROUND: Estradiol at baseline or after a classical gonadotropin-releasing hormone test did not reflect ovarian steroidogenesis in central precocious puberty (CPP) girls. AIMS: To evaluate estradiol response to depot triptorelin, both at start and during therapy to determine how active ovarian steroidogenesis is at pubertal stage and under therapy. METHODS: A prospective study was performed in 43 CPP girls. Serum luteinizing hormone and follicle-stimulating hormone at 3 h (LH-3h, FSH-3h) and estradiol at 24 h (E2-24h) after injection of depot triptorelin 3...
2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/26197466/anaphylaxis-to-gonadorelin-acetate-in-a-girl-with-central-precocious-puberty
#8
Onur Akın, Süleyman Tolga Yavuz, Bülent Hacıhamdioğlu, Erkan Sarı, Orhan Gürsel, Ediz Yeşilkaya
Gonadotropin-releasing hormone analogues are generally regarded as safe drugs. Gonadorelin acetate has been widely used for the diagnosis of central precocious puberty, and life-threatening reactions to gonadorelin acetate are extremely rare. Herein, we described - to the best of our knowledge - the first pediatric case in which severe anaphylaxis was encountered after intravenous gonadorelin acetate administration. An 8-year-old girl who was diagnosed with central precocious puberty was receiving triptorelin acetate treatment uneventfully for 6 months...
November 1, 2015: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/26095287/accuracy-of-endocrine-tests-for-detecting-hypogonadotropic-hypogonadism-in-girls
#9
Gerhard Binder, Roland Schweizer, Peter Haber, Gunnar Blumenstock, Regina Braun
OBJECTIVE: To assess the accuracy of inhibin B and the gonadotropin releasing hormone agonist test for the diagnosis of hypogonadotropic hypogonadism (HH). STUDY DESIGN: We performed a retrospective analysis of data collected 2009-2014 using a strict clinical protocol. All prepubertal nonunderweight girls, aged 13-17.5 years with Tanner breast stage B1/B2 and low estradiol levels, were tested and re-examined at 6-month intervals (n = 21). Constitutional delay of growth and puberty was defined by spontaneous menarche; HH was identified by association with specific causes of HH or no spontaneous progress of puberty during follow-up...
September 2015: Journal of Pediatrics
https://www.readbyqxmd.com/read/26092816/patient-reported-outcomes-with-adjuvant-exemestane-versus-tamoxifen-in-premenopausal-women-with-early-breast-cancer-undergoing-ovarian-suppression-text-and-soft-a-combined-analysis-of-two-phase-3-randomised-trials
#10
RANDOMIZED CONTROLLED TRIAL
Jürg Bernhard, Weixiu Luo, Karin Ribi, Marco Colleoni, Harold J Burstein, Carlo Tondini, Graziella Pinotti, Simon Spazzapan, Thomas Ruhstaller, Fabio Puglisi, Lorenzo Pavesi, Vani Parmar, Meredith M Regan, Olivia Pagani, Gini F Fleming, Prudence A Francis, Karen N Price, Alan S Coates, Richard D Gelber, Aron Goldhirsch, Barbara A Walley
BACKGROUND: The combined efficacy analysis of the TEXT and SOFT trials showed a significant disease-free survival benefit with exemestane plus ovarian function suppression (OFS) compared with tamoxifen plus OFS. We present patient-reported outcomes from these trials. METHODS: Between Nov 7, 2003, and April 7, 2011, 4717 premenopausal women with hormone-receptor positive breast cancer were enrolled in TEXT or SOFT to receive unmasked adjuvant treatment with 5 years of exemestane plus OFS or tamoxifen plus OFS...
July 2015: Lancet Oncology
https://www.readbyqxmd.com/read/25781535/monitoring-gonadotropin-releasing-hormone-analogue-gnrha-treatment-in-girls-with-central-precocious-puberty-a-comparison-of-four-methods
#11
Amnon Zung, Ella Burundukov, Mira Ulman, Tamar Glaser, Zvi Zadik
AIM: The objective of this study was to validate basal, post-gonadotropin-releasing hormone analogue (post-GnRHa) and first-voided urinary LH (ULH) as alternatives to an LHRH stimulation test in monitoring treatment efficacy in central precocious puberty (CPP). METHODS: Seventeen girls with CPP were followed over 22.5±9.1 months during GnRHa (triptorelin) treatment. ULH and post-GnRHa LH levels were obtained every 4 months before and 24 h after GnRHa administration, respectively, along with clinical and bone age (BA) evaluation...
July 2015: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/25676588/randomized-double-blind-dose-escalation-trial-of-triptorelin-for-ovary-protection-in-childhood-onset-systemic-lupus-erythematosus
#12
RANDOMIZED CONTROLLED TRIAL
Hermine I Brunner, Clovis A Silva, Andreas Reiff, Gloria C Higgins, Lisa Imundo, Calvin B Williams, Carol A Wallace, Nadia E Aikawa, Shannen Nelson, Marisa S Klein-Gitelman, Susan R Rose
OBJECTIVE: To determine the dose of triptorelin that is sufficient to maintain complete ovarian suppression in female patients with childhood-onset systemic lupus erythematosus (SLE) who require cyclophosphamide therapy, to determine the length of time needed to achieve ovarian suppression after initiation of triptorelin treatment, and to investigate the safety of triptorelin. METHODS: In this randomized, double-blind, placebo-controlled, dose-escalation study, female patients ages <21 years were randomized 4:1 to receive triptorelin (n = 25) or placebo (n = 6)...
May 2015: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/25407542/stability-permeability-and-growth-inhibitory-properties-of-gonadotropin-releasing-hormone-liposaccharides
#13
Daryn Goodwin, Pegah Varamini, Pavla Simerska, Istvan Toth
PURPOSE: In this study we aimed to address the poor drug-like properties of Gonadotropin-Releasing Hormone (GnRH) peptide through modification with lipids and carbohydrates. METHODS: GnRH peptide was conjugated to 2-amino-D,L-octanoic acid (C8) and 2-amino-D,L-dodecanoic acid (C12) in monomer and dimer, along with (6-9) or without (2-5 and 11) a glucose moiety. Peptides were tested for their biological activity using different tumour cell lines. The toxicity of the constructs was evaluated in peripheral blood mononuclear cells (PBMC)...
May 2015: Pharmaceutical Research
https://www.readbyqxmd.com/read/25299229/sertoli-leydig-cell-tumors-hormonal-profile-after-dynamic-test-with-gnrh-analogue-triptorelin-represents-a-useful-tool-to-evaluate-tumoral-hyperandrogenism
#14
J Turra, M Granzotto, M Gallea, D Faggian, L Conte, P Litta, R Vettor, R Mioni
We report the case of a 15-year-old woman with signs of hyperandrogenism affected by a Sertoli-Leydig cell tumor (SLCT). In our patient, blood analysis showed a high testosterone (T) level (T: 8.53 nmol/L; nv < 1.87 nmol/L) while the GnRH-analogue test demonstrated an exaggerated secretion of 17-hydroxyprogesterone (OHP), T, and androstenedione (A) by the ovary after stimulation. We compared the GnRH-analogue test of our patient with that obtained in a group of normal and healthy women (no. 8 subjects, 16-26 years old), men (no...
January 2015: Gynecological Endocrinology
https://www.readbyqxmd.com/read/25258460/cryoconservation-of-oocytes-in-a-patient-with-breast-cancer-and-intrauterine-early-pregnancy
#15
M Werling, A Tandler-Schneider, A Siemann, G Stief, H Kentenich
Case Report: A 38-year-old patient newly diagnosed with invasive ductal breast cancer wished to cryoconserve her unfertilised oocytes. Stimulation was started on the 26th day of her menstrual cycle with daily administration of 300 IE hMG s. c. and a GnRH antagonist (cetrorelix 0.25 mg s. c.). The patient additionally received an aromatase inhibitor during the first 5 days of stimulation (letrozole 5 mg p. o.). Induction of ovulation occurred on the 11th day of stimulation with hCG (10 000 IE s...
November 2012: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/25207430/inhibin-b-plus-lh-vs-gnrh-agonist-test-for-distinguishing-constitutional-delay-of-growth-and-puberty-from-isolated-hypogonadotropic-hypogonadism-in-boys
#16
Gerhard Binder, Roland Schweizer, Gunnar Blumenstock, Regina Braun
OBJECTIVE: The distinction between constitutional delay of growth and puberty (CDGP) and isolated hypogonadotropic hypogonadism (IHH) in males with delayed puberty is difficult but important for timely treatment. We assessed the accuracy of the GnRH agonist test (triptorelin 0·1 mg) in comparison with inhibin B alone or in combination with basal LH for the diagnosis of IHH. PATIENTS AND MEASUREMENTS: Ninety-seven prepubertal males aged 13·7-17·5 year, with testicular volumes ≤4 ml, were examined every 6 months...
January 2015: Clinical Endocrinology
https://www.readbyqxmd.com/read/25134291/risk-of-recurrent-menorrhagia-after-hydrothermoablation-role-of-gnrh-analogues-neoadjuvant-treatment-in-long-term-successful-rate
#17
RANDOMIZED CONTROLLED TRIAL
P Litta, C Saccardi, L Tommasi, J Di Giuseppe, G Delli Carpini, A Ciavattini
OBJECTIVE: To evaluate the long-term effectiveness of presurgical therapy with GnRH analogues in patients who underwenthydrothermal endometrial ablation (HTA) for menorrhagia and assess the relationship between sonographically measured myometrium thickness and pelvic pain. MATERIALS AND METHODS: A prospective randomized control study comparing 15 women (Group A) with presurgical subcutaneous triptorelin depot injection before HTA with controls (Group B, n = 15)...
2014: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/24771429/effects-of-gonadoliberin-analogue-triptorelin-on-the-pituitary-testicular-complex-in-neonatal-rats
#18
N N Dygalo, T V Shemenkova, T S Kalinina, G T Shishkina
Triptorelin, a synthetic analogue of neurohormone gonadoliberin (gonadotropin-releasing hormone, GnRH) administered daily to rats on postnatal days 5-7 suppressed the expression of GnRH receptor in the pituitary gland, but did not change functioning of the pituitary-testicular complex. Administration of triptorelin on postnatal days 12-14 (i.e. during the formation of pulsatile pattern of GnRH secretion and increasing levels of its mRNA receptor in the pituitary gland) had no effect on receptor expression, but increased the levels of luteinizing hormone mRNA in the pituitary gland and the weight of testes...
February 2014: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/24748338/does-cabergoline-help-in-decreasing-endometrioma-size-compared-to-lhrh-agonist-a-prospective-randomized-study
#19
RANDOMIZED CONTROLLED TRIAL
Amr M Salaheldin Abdel Hamid, Wael A Ismail Madkour, Ashraf Moawad, Mohamed Abd Elzaher, Mary P Roberts
AIM: The aim of this study was to compare the efficiency of dopamine agonist, Cabergoline, in decreasing the size of endometrioma, with that of luteinizing hormone releasing hormone (LHRH) agonist, triptorelin acetate. STUDY: This was a prospective, randomized study. SETTING: The setting was in two private medical centers in the UAE, from January 2011 to February 2012. PATIENTS AND METHODS: One hundred and forty patients complaining of endometrioma, and fulfilling the eligibility criteria, were chosen and divided into two groups as follows: Group I comprised 71 patients; all of them received Cabergoline tablets, 0...
October 2014: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/24725419/effect-of-gnrh-analogs-in-postnatal-domestic-cats
#20
RANDOMIZED CONTROLLED TRIAL
A Carranza, M Faya, M Lopez Merlo, P Batista, C Gobello
The aim of this study was to reproductively assess the clinical and hormonal effects of a GnRH agonist (AG) and an antagonist (AN) administered during the postnatal period in domestic cats. Forty-eight male and female postnatal kittens were randomly assigned to deslorelin acetate 1.6 mg subcutaneous (AG; n = 16), acyline 33 μg/100 g subcutaneous weekly for 3 months (AN; n = 16), or control (CO; n = 16) which remained untreated. The cats were followed up (behavioral observation, physical examination, fecal sexual steroid determinations, mating test, and pregnancy diagnosis) up to puberty...
July 1, 2014: Theriogenology
keyword
keyword
52927
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"