keyword
https://read.qxmd.com/read/38389757/complex-management-of-pulmonary-embolism-in-apla-syndrome-a-case-study-of-ecmo-and-bivalirudin-utilization
#1
Somnath Das, Unmesh Chakraborty, Abhinaba Sarkar, Atanu Saha, Pradeep Narayan
We report a case of a 22-year-old female with antiphospholipid antibody (APLA) syndrome who presented with severe dyspnea. Diagnostic imaging confirmed pulmonary embolism (PE), and treatment comprised unfractionated heparin and apixaban. APLA syndrome was diagnosed based on clinical, serological, and radiological findings. During evaluation, the patient developed cardiogenic shock necessitating catheter-directed thrombolysis, followed by veno-arterial extracorporeal membrane oxygenation (VA-ECMO) due to deteriorating condition and suspected heparin-induced thrombocytopenia (HIT)...
March 2024: Indian Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/38195020/anti-phosphatidyl-serine-prothrombin-aps-pt-antibodies-are-superior-predictors-of-lac-presence-and-aps-diagnoses-a-single-center-study
#2
JOURNAL ARTICLE
Abdulrahman Saadalla, Vijayalakshmi Nandakumar
BACKGROUND AND AIMS: Several non-criteria (NC) anti-phospholipid antibodies (APLA) have been proposed as candidates for antiphospholipid antibody syndrome (APS) diagnosis. The objectives of this study were 1) to determine the association of five different NC-APLA with positivity for Lupus anti-coagulant (LAC) and the criteria antibodies anti-cardiolipin (aCL) and anti-beta glycoprotein (aB2GPI), and 2) to assess the ability of NC-APLA to predict LAC presence and clinical APS diagnoses...
January 7, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/38186430/gender-equality-in-antiphospholipid-syndrome-publications-a-comprehensive-analysis-of-first-author-trends
#3
REVIEW
Mahima Kuruvila, Eden Estevez, Aruna Anantharaj, Anjali Mediboina
Antiphospholipid syndrome (APS) is a condition characterized by the production of procoagulant antibodies, which in turn increases the risk of thrombotic events in multiple blood vessels and is associated with recurrent miscarriages and premature births. The study aimed to identify and analyze the gender trends of the first authors in PubMed-indexed publications related to APS. The present cross-sectional study analyzed all PubMed-indexed articles published between January 2018 and December 2022. All articles with the term "antiphospholipid syndrome" in their titles were included in the study...
December 2023: Curēus
https://read.qxmd.com/read/38137338/antiphospholipid-antibodies-and-vascular-thrombosis-in-patients-with-severe-forms-of-covid-19
#4
JOURNAL ARTICLE
Mirjana Zlatković-Švenda, Milica Ovuka, Manca Ogrič, Saša Čučnik, Polona Žigon, Aleksandar Radivčev, Marija Zdravković, Goran Radunović
Antiphospholipid antibodies (aPLA) are a laboratory criterion for the classification of antiphospholipid syndrome (APS) and are known to cause clinical symptoms such as vascular thrombosis or obstetric complications. It is suggested that aPLA may be associated with thromboembolism in severe COVID-19 cases. Therefore, we aimed to combine clinical data with laboratory findings of aPLA at four time points (admission, worsening, discharge, and 3-month follow-up) in patients hospitalized with COVID-19 pneumonia...
November 22, 2023: Biomedicines
https://read.qxmd.com/read/38082159/pattern-of-disease-expression-in-sle-patients-with-antiphospholipid-antibodies-data-from-indian-systemic-lupus-erythematosus-inception-cohort-inspire
#5
JOURNAL ARTICLE
Vineeta Shobha, Liza Rajasekhar, Sandra Manuel, V Nayana, Chengappa Kavadichanda, Deepika Kounassegarane, Ashish J Mathew, Ranjan Gupta, Manish Rathi, Parasar Ghosh, Saumya Ranjan Tripathy, Bidyut Das, Sumithra Selvam, Abhishek Kumar Singh, Ankita Singh, Avinash Jain, Amita Aggarwal
Antiphospholipid antibodies (APLA) are present in one-third of systemic lupus erythematosus (SLE) patients, and they are associated with both criteria and non-criteria manifestations. We studied the prevalence, clinical associations, and impact on mortality of APLA in SLE patients from India. Among the Indian SLE inception cohort (INSPIRE), patients who had data on all five routinely performed APLAs [lupus anticoagulant (LA), IgG and IgM anticardiolipin antibody (aCL) and anti-β2-glycoprotein I(β2GPI)] at enrolment were selected...
December 12, 2023: Rheumatology International
https://read.qxmd.com/read/38074071/unveiling-complexity-a-case-report-of-catastrophic-antiphospholipid-syndrome-with-coronary-occlusion-and-a-concomitant-patent-foramen-ovale-shunt
#6
Nava R Sharma, Sudarshan Gautam, Prabal Kc, Sajog Kansakar, Marlon E Rivera Boadla, Madalasa Pokhrel, Arjun Basnet, Saral Lamichhane
Antiphospholipid syndrome (APLS) and systemic lupus erythematosus (SLE) are rare autoimmune disorders that afflict a small percentage of the global female population. The complexity of these conditions is further exacerbated by their propensity to give rise to recurrent thrombosis and obstetric morbidity, thereby posing intricate challenges for clinicians and patients alike. One of the most concerning aspects of these diseases is the heightened risk they confer for accelerated atherosclerosis, which can ultimately culminate in the development of acute coronary syndrome (ACS)...
November 2023: Curēus
https://read.qxmd.com/read/37950993/a-rare-concurrent-incidence-of-adult-onset-acute-disseminated-encephalomyelitis-and-antiphospholipid-antibody-syndrome-a-case-report
#7
Farhan Ali, Amraha Zubair, Aftab Ahmed, Azizullah Jalbani, Hassan Mumtaz
INTRODUCTION: Acute disseminated encephalomyelitis (ADEM) is a demyelinating immune-mediated condition of the central nervous system, whereas antiphospholipid antibody syndrome (APLA) is an autoimmune disorder accompanied by thrombosis and pregnancy-related problems. We present a unique case of a 30-year-old female with ADEM coexisting with APLA, highlighting the importance of early identification and specialized care. PRESENTATION OF CASE: We present a case of a 30-year-old woman with a history of hypertension, multiple miscarriages, and non-compliance with medication, who presented with altered consciousness and weakness in all four limbs...
November 4, 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37942411/complement-mediated-thrombotic-microangiopathy-in-pregnancy-an-educational-case-report
#8
Valentina Bruno, David Barth, Arenn Jauhal
RATIONALE: Thrombotic microangiopathy (TMA) is a spectrum of rare diseases characterized by thrombocytopenia, microangiopathic hemolytic anemia, and organ damage. Differentiating pre-eclampsia, HELLP (Hemolysis, Elevated Liver enzymes, Low Platelets) syndrome and atypical hemolytic uremic syndrome (aHUS) during pregnancy may be diagnostically challenging yet important as the treatment pathways differ. Most cases of aHUS are associated with dysregulation of the complement alternative pathway, for which current guidelines recommend prompt treatment with complement C5 inhibitor to prevent chronic sequelae...
2023: Canadian Journal of Kidney Health and Disease
https://read.qxmd.com/read/37855591/isolated-intracranial-hypertension-without-cerebral-venous-sinus-thrombosis-in-apla-syndrome-an-unique-association
#9
JOURNAL ARTICLE
Camelia Porey, Binaya Kumar Jaiswal
BACKGROUND: Antiphospholipid antibody (APLA) syndrome is an autoimmune disorder predisposing to thrombotic complications affecting CNS either by arterial vaso occlusion or venous thrombosis. Cerebral venous sinus thrombosis (CVST) secondarily produces raised intracranial pressure (ICP). However intracranial hypertension without evidence of CVST is rare entity.Case presentation: We present two cases of elevated ICP with absence of identifiable CVST. Case 1, a 28-year-old female presented with a 2 months history of headache followed by bilateral vision loss...
October 19, 2023: International Journal of Neuroscience
https://read.qxmd.com/read/37653060/successful-pregnancies-in-a-patient-with-takayasu-arteritis-and-antiphospholipid-syndrome-maintained-on-infliximab-corticosteroid-free-regimen-case-based-review
#10
REVIEW
Zikica Jovicic, Sanja Dragasevic, Ana Petkovic, Snezana Plesinac, Aleksandra Sokic Milutinovic, Maja Stojanovic
Takayasu arteritis (TA) is a large vessel vasculitis affecting predominantly females below the age of 40. Patients with TA seem to be at increased risk for adverse pregnancy outcomes, resulting in mother or child complications. Although few studies analyzed the presence of antiphospholipid antibodies (APLA) in TA patients, an association between antiphospholipid syndrome (APS) and TA is rarely reported in the literature, mainly in the form of case reports. In fact, very few data regarding pregnancy outcomes in patients with TA and APS are available...
September 1, 2023: Rheumatology International
https://read.qxmd.com/read/37626797/thrombosis-and-hyperinflammation-in-covid-19-acute-phase-are-related-to-anti-phosphatidylserine-and-anti-phosphatidylinositol-antibody-positivity
#11
JOURNAL ARTICLE
Jaume Alijotas-Reig, Ariadna Anunciación-Llunell, Stephanie Morales-Pérez, Jaume Trapé, Enrique Esteve-Valverde, Francesc Miro-Mur
Antiphospholipid antibodies (APLA) are strongly associated with thrombosis seen in patients with antiphospholipid syndrome. In COVID-19, thrombosis has been observed as one of the main comorbidities. In patients hospitalised for COVID-19, we want to check whether APLA positivity is associated with COVID-19-related thrombosis, inflammation, severity of disease, or long COVID-19. We enrolled 92 hospitalised patients with COVID-19 between March and April 2020 who were tested for 18 different APLAs (IgG and IgM) with a single line-immunoassay test...
August 18, 2023: Biomedicines
https://read.qxmd.com/read/37610562/prothrombotic-states-in-portal-vein-thrombosis-and-budd-chiari-syndrome-in-india-a-systematic-review-and-meta-analysis
#12
REVIEW
Suprabhat Giri, Sumaswi Angadi, Jijo Varghese, Sridhar Sundaram, Sukanya Bhrugumalla
BACKGROUND: Both Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT) have been linked to various prothrombotic (PT) conditions. The PT profile in Asians is different from the west and there are no nationwide epidemiological surveys from India. Hence, the present meta-analysis was aimed at analyzing the prevalence of acquired and hereditary thrombophilia among Indian patients with non-cirrhotic PVT and BCS. METHODS: A comprehensive literature search of Embase, Medline and Scopus was conducted from January 2000 to February 2022 for studies evaluating the prevalence of various PT conditions in Indian patients with PVT and BCS...
October 2023: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/37602169/a-case-of-branch-retinal-artery-occlusion-postcataract-surgery-in-an-antiphospholipid-syndrome-patient
#13
Gagan Bhatia, Sandeep Kumar, Daraius Shroff, Priyanka Gupta
A 46-year-old female with preoperative vision 6/18 N18 (LogMar 0.5) in re and posterior subcapsular cataract underwent an uneventful phacoemulsification surgery under a peribulbar block. On the postoperative day 2, she complained of no visual gain in the operated eye. The reported vision was counting fingers close to the face. Through multimodal imaging (MMI), a diagnosis of branched retinal artery occlusion (BRAO) was made. A detailed consultation and history taking with the patient revealed a concealed history of four miscarriages in the past...
2023: Oman Journal of Ophthalmology
https://read.qxmd.com/read/37530377/celiac-artery-thrombosis-presenting-as-acute-abdomen
#14
M Sharma, K Natarajan, A Mahesh Kumar, P Paramasivan
Mesenteric vascular thrombosis, typically of the superior mesenteric artery, is a frequent occurrence in patients with hypercoagulable conditions. Isolated involvement of the celiac artery is rare. Patients with celiac artery thrombosis can present with an acute abdomen or occasionally with acid peptic symptoms. A delay in diagnosis is associated with high rates of morbidity and mortality. We present a rare case of splenic infarction with celiac trunk thrombosis in a 54-year-old patient with underlying antiphospholipid (APLA) syndrome who presented with epigastric pain that was mistaken for symptoms of acid reflux...
July 31, 2023: Journal of Postgraduate Medicine
https://read.qxmd.com/read/37437504/factors-influencing-real-life-use-of-direct-oral-anticoagulants-in-patients-with-cerebral-sinus-and-venous-thrombosis
#15
JOURNAL ARTICLE
Naaem Simaan, Jeremy Molad, Asaf Honig, Andrei Filioglo, Shlomi Peretz, Fadi Shbat, Tarek Mansor, Waleed Abu-Shaheen, Ronen R Leker
BACKGROUND: Direct oral anticoagulants (DOAC) are advocated as equally effective to vitamin K antagonists (VKA) for the treatment of patients with cerebral sinus and venous thrombosis (CSVT). However, data concerning the real-life management practices in CSVT patients are is lacking. METHODS: Prospective CSVT databases from four large academic medical centers were retrospectively studied. Demographics, clinical presentations, risk factors, radiological and outcome parameters were compared between CSVT patients treated with DOAC and VKA...
July 10, 2023: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/37318546/bilateral-central-retinal-artery-occlusion-as-a-presenting-manifestation-of-systemic-lupus-erythematosus-a-case-based-review
#16
REVIEW
Xin Chen, Xiaowei Shi, Jinyu Li, Wenwen Wang, Chao Wang, Qi Cheng, Yifan Xie, Jing Xue, Yan Du
Central retinal artery occlusion (CRAO) is an ophthalmic emergency that typically results in permanent vision damage even despite vigorous treatment. In this article, we describe a case of acute vaso-occlusive retinopathy that presented as the primary manifestation of SLE in the absence of elevated levels of APLAs. After treatment with intravenous steroids, immunoglobulin, intrathecal injection of dexamethasone, plasma exchange, and intravenous cyclophosphamide, SLE was well controlled in the patient, but her vision was permanently lost in the left eye...
October 2023: Rheumatology International
https://read.qxmd.com/read/37264223/positive-antiphospholipid-antibodies-observation-or-treatment
#17
REVIEW
Bogna Grygiel-Górniak, Łukasz Mazurkiewicz
Antiphospholipid antibodies (APLAs) are  primarily directed toward phospholipid-binding proteins and are responsible for thrombotic events. APLAs include anti-β2Glycoprotein I (anti-β2GPI), anticardiolipin (anti-CL) antibodies, and lupus anticoagulant. These antibodies are typical markers of antiphospholipid syndrome (APS) and are a part of its diagnostic criteria. Many data underline the presence of APLAs in other rheumatic diseases (e.g., systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, rheumatoid arthritis and Behçet's disease)...
June 1, 2023: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/37247169/advances-in-management-of-the-stroke-etiology-one-percenters
#18
REVIEW
Nicholas D Osteraas, Rima M Dafer
PURPOSE OF REVIEW: Uncommon causes of stroke merit specific attention; when clinicians have less common etiologies of stoke in mind, the diagnosis may come more easily. This is key, as optimal management will in many cases differs significantly from "standard" care. RECENT FINDINGS: Randomized controlled trials (RCT) on the best medical therapy in the treatment of cervical artery dissection (CeAD) have demonstrated low rates of ischemia with both antiplatelet and vitamin K antagonism...
May 29, 2023: Current Neurology and Neuroscience Reports
https://read.qxmd.com/read/37191363/antiphospholipid-antibodies-in-convalescent-plasma-of-donors-recovered-from-mild-covid-19-infection
#19
JOURNAL ARTICLE
Dorit Blickstein, Marina Izak, Talia Filipovich-Rimon, Osnat Garach-Jehoshua, Naomi Rahimi-Levene, Eilat Shinar, Ramzia Abu Hamad, Adina Bar-Chaim, Maya Koren-Michowitz
BACKGROUND AND OBJECTIVES: Passive immunization by the infusion of convalescent plasma (CP) obtained from patients who have recently recovered from COVID-19, thus having antibodies to severe acute respiratory syndrome coronavirus 2, is a potential strategy to reduce the severity of illness. A high prevalence of antiphospholipid antibodies (APLA) in patients with COVID-19 has been reported during the pandemic, raising a concern whether the use of CP could increase the risk of thrombosis in transfused patients...
May 16, 2023: Vox Sanguinis
https://read.qxmd.com/read/36820549/catastrophic-antiphospholipid-syndrome-in-lupus-associated-immune-thrombocytopenia-treated-with-eltrombopag-a-case-series-and-literature-review
#20
REVIEW
Wakar Garra, Or Carmi, Shaye Kivity, Yair Levy
BACKGROUND: Eltrombopag, a thrombopoietin receptor (TPO-R) agonist, is considered a second-line treatment for patients with refractory immune thrombocytopenia (ITP). Systemic lupus erythematosus (SLE) is frequently associated with ITP. In some cases, thrombocytopenia in SLE patients is attributed to concurrent antiphospholipid antibodies (APLA). Currently, data regarding treatment with TPO-R agonists for ITP in SLE or APLA patients are limited. The incidence of SLE flare or antiphospholipid syndrome while on TPO-R agonists has not been well-studied...
February 10, 2023: Medicine (Baltimore)
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