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Auto immune haemolytic anaemia

Kristoffer Vogler, Lisbeth Samsø Schmidt
The most commonly known clinical manifestation of primary Epstein-Barr virus infection is infectious mononucleosis. In this review we cover the diagnostics and basic patho-physiology of Epstein-Barr virus infection and present the many clinical manifestations of the virus, including less well-known diseases such as hepatitis, auto-immune haemolytic anaemia, and neurological and immunological diseases. Our aim is to strengthen the clinicians' awareness and understanding of these conditions in order to improve diagnostics and avoid delay of treatment...
May 14, 2018: Ugeskrift for Laeger
Devarajan Rathish, Sisira Siribaddana
Background: Tuberculosis induced autoimmune haemolytic anaemia is a rare entity. The aim of this study was to explore its common presentations, investigation findings and treatment options through a systematic review of published reports. Methods: PubMed, Trip, Google Scholar, Science Direct, Cochrane Library, Open-Grey, Grey literature report and the reference lists of the selected articles were searched for case reports in English on tuberculosis induced auto-immune haemolytic anaemia...
2018: Allergy, Asthma, and Clinical Immunology
Samarth Virmani, Rama Bhat, Raghavendra Rao, Ruchee Khanna, Lipisha Agarwal
Patients living with HIV are commonly diagnosed with anaemia which can have various aetiologies. However, one of the rare causes of anaemia in such patients is Auto Immune Haemolytic Anaemia (AIHA), which is difficult to diagnose due to the absence of reticulocytosis in HIV patients. Such patients can be treated with corticosteroids which can gradually be tapered off over a period of time. The following is a case of a 52-year-old male living with HIV who was diagnosed to have AIHA and was successfully treated with steroids...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
F Pasquet, M Pavic, J Ninet, A Hot
Autoimmune diseases may reveal or occur during the course of a neoplasia or its treatment. Autoimmune cytopenia, especially haemolytic anaemia, is common in lymphoproliferative disorders such as chronic lymphoid leukemia. The link between cancer and myositis is well established. Dermatomyositis is associated with an increased relative risk of cancer of 3.4 to 4.4. A combination of detection of antibodies against p155 and TEP-computed tomography may be the best approach to ascertain the presence of occult malignancy in patients with dermatomyositis...
October 2014: La Revue de Médecine Interne
Geert Paes, Dominique Paepe, Evelyne Meyer, Annemarie T Kristensen, Luc Duchateau, Miguel Campos, Sylvie Daminet
BACKGROUND: Diagnosing canine immune-mediated haemolytic anaemia (IMHA) is often challenging because all currently available tests have their limitations. Dogs with IMHA often have an increased erythrocyte osmotic fragility (OF), a characteristic that is sometimes used in the diagnosis of IMHA. Since the classic osmotic fragility test (COFT) is time-consuming and requires specialized equipment, an easy and less labour-intensive rapid osmotic fragility test (ROFT) has been used in some countries, but its diagnostic value has not yet been investigated...
October 25, 2013: Acta Veterinaria Scandinavica
Susanta Kumar Das, Amritava Ghosh, Niloy Banerjee, Sudarshan Khaskil, Sabya Sachi Mukherjee
Chronic cold agglutinin disease is a subgroup of auto-immune haemolytic anaemia. Primary cold agglutinin disease has traditionally been defined by the absence of any underlying or associated disease. It usually affects elderly. The term cold refers to the fact that the auto-antibody involved reacts with red cells poorly or not at all at 37 degrees C, whereas it reacts strongly at lower temperature. Here a case of severe pallor, jaundice and red colour urine in winter season for last 10 years diagnosed as a case of primary cold agglutinin disease is reported...
October 2012: Journal of the Indian Medical Association
Ben Creelan, Kerry Thomas, Kamal Massis, Ryan M Davis
No abstract text is available yet for this article.
April 2013: British Journal of Haematology
Debbie G J Robbrecht, Fazil Alidjan, Bob Eikemans, Dirk A W Haans, Coen van Guldener, Peter van Wijngaarden
Mesenteric panniculitis is a non-specific inflammation of the mesenteric adipose tissue, with varying degrees of fibrosis and fat necrosis. It can be associated with varying diseases and conditions, such as autoimmune disease and cancer. Many doctors are not familiar with this disease or do not know how to interpret the signs and symptoms. Here, we describe three patients illustrating the variety of clinical course, diagnostics, prognosis and treatment. A 44-year-old woman suffering from episodic abdominal pain was diagnosed with uncomplicated mesenteric panniculitis...
2012: Nederlands Tijdschrift Voor Geneeskunde
Vidyasagar Devaprasad Dedeepiya, Hiroshi Terunuma, Xuewen Deng, Subramani Baskar, Sadananda Rao Manjunath, Rajappa Senthilkumar, Palanisamy Murugan, Paramasivam Thamaraikannan, Thangavelu Srinivasan, Senthilkumar Preethy, Samuel J K Abraham
The functional profile of natural killer (NK) cells has been reported to be lower in auto-immune haemolytic anaemia (AIHA). In this study, we report a comparative analysis of peripheral blood mononuclear cells (PBMNCs) and the in vitro expansion of NK cells in a patient with AIHA and cancer, with that of other cancer patients without AIHA. PBMNCs and in vitro NK-cell expansion of a 64-year old female patient with ovarian cancer and AIHA was compared with that of four other patients with cancer without AIHA who underwent autologous immune enhancement therapy (AIET)...
February 2012: Oncology Letters
Kushal Naha, Sayali Thakare, G Vivek, Mukhyaprana Prabhu
A 40-year-old previously healthy male presented with acute onset painless dimness of vision in both eyes since the past week and low-grade fever, anorexia and weight loss for the past 1 month. He had been evaluated at a local hospital and diagnosed to have a posterior cerebral artery territory infarct on the left side on the strength of cranial CT. Shortly after receiving antiplatelets and warfarin he had developed severe coagulopathy as evidenced by haematemesis, epistaxis and haematuria. Preliminary investigation revealed prolonged clotting parameters, renal failure and anaemia...
2012: BMJ Case Reports
Prabodh Chandra Mondal, Partha Pratim Chakraborty, Mitali Bera
A 4-year-old girl presented with severe pallor and intermittent passage of cola-coloured urine. Routine investigations were suggestive of auto-immune haemolytic anaemia. Red cell agglutination was observed in peripheral smear and patient's serum was positive for cold agglutinins. Thorough work-up ruled out secondary cold agglutinin disease. Patient was treated successfully with corticosteroids.
July 2011: Journal of the Indian Medical Association
L Chauffrey, P Chamouni, L Bégarin, Y Benhamou, N Cailleux, J-Y Borg, M-P Callat, N Schlegel, H Lévesque
INTRODUCTION: The MYH9 syndrome is a group of rare autosomal dominant platelet disorders associating in most of the cases a macrothrombocytopenia and characteristic leukocyte inclusions. Clinical features may include renal, visual, or hearing impairment. The bleeding tendency is usually moderate. CASE REPORT: We report a 28-year-old-man, with an auto-immune haemolytic anaemia associated with a MYH9 syndrome. CONCLUSION: To our knowledge, this is the first report of such an association...
February 2012: La Revue de Médecine Interne
R Sitcharungsi, U Anurathapan, N Sirachainan, P Chanthavanich
A 7-month-old Myanmar boy was admitted with a 3-day history of fever. He was markedly pale and his temperature was 38·2°C. Peripheral blood smear demonstrated Plasmodium vivax infection with spherocytosis and auto-agglutination of red blood cells. Haematocrit was 16% and reticulocyte count 14·9%. Direct and indirect antiglobulin tests were positive. Antibody analysis was positive for auto-antigen I. P. vivax malaria with auto-immune haemolytic anaemia (AIHA) was diagnosed. He was treated with chloroquine and primaquine for the P...
2011: Annals of Tropical Paediatrics
Norman Oneil Machado, Christopher S Grant, Salam Alkindi, Shahina Daar, Nayil Al-Kindy, Zakia Al Lamki, S S Ganguly
BACKGROUND: Haematological disorders, in particular sickle cell disease (SCD) and thalassaemia, are relatively common in Oman. We report our experience of splenectomy for haematological disorders and review the literature on splenectomy role in their management. OBJECTIVES: To review our experience in the management of 150 patients with haematological disorders undergoing splenectomy with emphasis on indications and outcome. To compare our experience with those reported from outside this region...
October 2009: International Journal of Surgery
Daan Dierickx, G Verhoef, A Van Hoof, P Mineur, A Roest, A Triffet, A Kentos, P Pierre, D Boulet, G Bries, P-Q Lê, A Janssens, A Delannoy
OBJECTIVES: For better characterizing the effect of anti-CD20 therapy, we analysed the use of rituximab in Belgian patients experiencing auto-immune haemolytic anaemia (AIHA) and immune thrombocytopenic purpura (ITP). DESIGN: We performed a retrospective multicentric analysis of patients with AIHA and ITP treated with rituximab in Belgium. SETTING: Haematological departments were invited to fill in a questionnaire about patient and disease characteristics...
November 2009: Journal of Internal Medicine
Spyros Aslanidis, Athina Pyrpasopoulou, Kostas Kontotasios, Stella Doumas, Chryssanthos Zamboulis
Parvovirus B19 infection has been associated with a variety of rheumatic manifestations/diseases, mainly rheumatoid arthritis, vasculitis and systemic lupus erythematosus (SLE). B19 infection may simulate both clinical and laboratory features of SLE, presenting either as a potential first time diagnosis of SLE or as an exacerbation of previously established disease. The similarities in both clinical and serological features of parvovirus infection and SLE at presentation may hinder the differential diagnosis between these two conditions...
July 2008: European Journal of Internal Medicine
A Elira Dokekias, I Koko, F O Atipo Galiba, A Martin
The authors report a peculiar form of Hodgkin's disease that is associated with Epstein-Barr virus infection. A 16-year-old patient was admitted for an autoimmune haemolytic anaemia associated with IgG auto-immune antibodies, linked to general clinical complications, cervical adenopathies and splenomegalia. The patient underwent hemicavectomy that was not histologically investigated. The ganglionar exeresis helped to establish the histological diagnosis of Hodgkin's disease, classic form with nodular sclerosis...
October 2007: Bulletin de la Société de Pathologie Exotique
D Grimaldi, N Limal, F Noizat-Pirenne, D Janvier, B Godeau, M Michel
INTRODUCTION: Confirmation of autoimmune hemolytic anaemia usually relies on the detection of erythrocyte membrane-bound autoantibodies using a direct antiglobulin test. In the rare case of IgA autoantibodies-mediated autoimmune hemolytic anemia, the direct antiglobulin test can be negative, because routinely used polyspecific direct antiglobulin test reagents contain only anti-IgG and anticomplement antibodies. EXEGESIS: We report the case of a 41-year-old woman presenting a severe autoimmune hemolytic anaemia caused by the presence of warm autoantibodies of IgA type that revealed a chronic hepatitis C virus infection...
February 2008: La Revue de Médecine Interne
Gautam Borthakur, Susan O'Brien, William G Wierda, Deborah A Thomas, Jorge E Cortes, Francis J Giles, Hagop M Kantarjian, Susan Lerner, Michael J Keating
Immune anaemias (IA) [auto-immune haemolytic anaemia (AIHA) and pure red cell aplasia (PRCA)] are complications of chronic lymphocytic leukaemia (CLL). Fludarabine has been associated with AIHA, whereas both rituximab and cyclophosphamide have been used to treat this condition. Combining these agents with fludarabine may reduce the likelihood of AIHA. We report on the incidence, outcome and pretreatment predictors of IA in 300 patients treated with fludarabine, cyclophosphamide and rituximab (FCR). Nineteen patients (6...
March 2007: British Journal of Haematology
Sophie Larrar, Corinne Guitton, Marjolaine Willems, Brigitte Bader-Meunier
Rituximab use in severe auto-immune diseases has recently increased. Scattered reports of opportunistic infections were the only reported serious side effects related to rituximab in pediatric patients .Here, we report transient severe acute thrombocytopenia and neutropenia respectively a few days after rituximab infusion in two children with autoimmune haemolytic anaemia. In both cases, cytopenia was reversible in a few days. The occurrence of cytopenias shortly after an infusion and their rapid reversibility suggest that these hematological side-effects were attributable to a direct toxicity of rituximab...
August 2006: Haematologica
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