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https://www.readbyqxmd.com/read/28944711/a-hybrid-composite-system-of-biphasic-calcium-phosphate-granules-loaded-with-hyaluronic-acid-gelatin-hydrogel-for-bone-regeneration
#1
Omar Faruq, Boram Kim, Andrew R Padalhin, Gun Hee Lee, Byong-Taek Lee
An ideal bone substitute should be made of biocompatible materials that mimic the structure, characteristics, and functions of natural bone. Many researchers have worked on the fabrication of different bone scaffold systems including ceramic-polymer hybrid system. In the present study, we incorporated hyaluronic acid-gelatin hydrogel to micro-channeled biphasic calcium phosphate granules as a carrier to improve cell attachment and proliferation through highly interconnected porous structure. This hybrid system is composed of ceramic biphasic calcium phosphate granules measuring 1 mm in diameter with seven holes and hyaluronic acid-gelatin hydrogel...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28942157/control-of-cell-adhesion-and-proliferation-utilizing-polysaccharide-composite-film-scaffolds
#2
Kazutoshi Iijima, Yuna Tsuji, Izumi Kuriki, Atsushi Kakimoto, Yuichi Nikaido, Rie Ninomiya, Takuya Iyoda, Fumio Fukai, Mineo Hashizume
We have developed polysaccharide composite films made of anionic polysaccharides and chitosan (CHI) by utilizing hot press techniques. In order to demonstrate the versatility of these films as cell scaffolds, the present study investigated the adhesion and proliferation of fibroblasts on composite films prepared by using various kinds of anionic polysaccharides and that were modified with proteins. Cells were spread on heparin/CHI and alginic acid/CHI films and grew well, whereas those on chondroitin sulfate C (CS)/CHI and hyaluronic acid/CHI films were round in shape...
September 14, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28941321/solubilized-amnion-membrane-hyaluronic-acid-hydrogel-accelerates-full-thickness-wound-healing
#3
Sean V Murphy, Aleksander Skardal, Lujie Song, Khiry Sutton, Rebecca Haug, David L Mack, John Jackson, Shay Soker, Anthony Atala
The early and effective treatment of wounds is vital to ensure proper wound closure and healing with appropriate functional and cosmetic outcomes. The use of human amnion membranes for wound care has been shown to be safe and effective. However, the difficulty in handling and placing thin sheets of membrane, and the high costs associated with the use of living cellularized tissue has limited the clinical application of amniotic membrane wound healing products. Here, we describe a novel amnion membrane-derived product, processed to result in a cell-free solution, while maintaining high concentrations of cell-derived cytokines and growth factors...
September 23, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28941282/engineering-of-cell-membrane-to-enhance-heterologous-production-of-hyaluronic-acid-in-bacillus-subtilis
#4
Adam W Westbrook, Xiang Ren, Murray Moo-Young, C Perry Chou
Hyaluronic acid (HA) is a high-value biopolymer used in the biomedical, pharmaceutical, cosmetic, and food industries. Current methods of HA production, including extraction from animal sources and streptococcal cultivations, are associated with high costs and health risks. Accordingly, the development of bioprocesses for HA production centered on robust 'Generally Recognized as Safe (GRAS)' organisms such as Bacillus subtilis is highly attractive. Here, we report the development of novel strains of B. subtilis in which the membrane cardiolipin (CL) content and distribution has been engineered to enhance the functional expression of heterologously expressed hyaluronan synthase of Streptococcus equisimilis (SeHAS), in turn, improving the culture performance for HA production...
September 23, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28941173/the-influence-of-hyaluronic-acid-and-glioblastoma-cell-coculture-on-the-formation-of-endothelial-cell-networks-in-gelatin-hydrogels
#5
Mai T Ngo, Brendan A Harley
Glioblastoma (GBM) is the most common and deadly form of brain cancer. Interactions between GBM cells and vasculature in vivo contribute to poor clinical outcomes, with GBM-induced vessel co-option, regression, and subsequent angiogenesis strongly influencing GBM invasion. Here, elements of the GBM perivascular niche are incorporated into a methacrylamide-functionalized gelatin hydrogel as a means to examine GBM-vessel interactions. The complexity of 3D endothelial cell networks formed from human umbilical vein endothelial cells and normal human lung fibroblasts as a function of hydrogel properties and vascular endothelial growth factor (VEGF) presentation is presented...
September 22, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28940204/adipose-derived-mesenchymal-stromal-cells-prevented-rat-vocal-fold-scarring
#6
Tsuyoshi Morisaki, Yo Kishimoto, Ichiro Tateya, Yoshitaka Kawai, Ryo Suzuki, Takuya Tsuji, Nao Hiwatashi, Tatsuo Nakamura, Koichi Omori, Hiroya Kitano, Hiromi Takeuchi, Shigeru Hirano
OBJECTIVES/HYPOTHESIS: This study aimed to reveal the effects of adipose-derived mesenchymal stromal cells (ASCs) on prevention of vocal fold scarring by investigating how the immediate ASCs transplantation into the injured rat vocal fold affect the levels of gene transcription and translation. STUDY DESIGN: Prospective animal experiments with controls. METHODS: ASCs harvested from green fluorescent protein transgenic rat (ASCs group) or saline (sham group) were injected into the thyroarytenoid muscle of Sprague-Dawley rats immediately after stripping the vocal fold...
September 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28939462/enhanced-cell-viability-in-hyaluronic-acid-coated-poly-lactic-co-glycolic-acid-porous-scaffolds-within-microfluidic-channels
#7
Fernanda Zamboni, Marie Keays, Sheri Hayes, Ahmad B Albadarin, Gavin M Walker, Patrick A Kiely, Maurice N Collins
The concept of the present work is to produce porous optimised scaffolds of poly(lactic-co-glycolic acid) (PLGA) coated with hyaluronic acid (HA), to provide a suitable microenvironment for cellular proliferation. Freeze dried scaffolds were produced from PLGA with varying lactic acid and glycolic acid ratios along the polymer backbone, as follows: 50:50 ester terminated, 50:50 carboxylate end-group and 85:15 ester terminated. Subsequently, these scaffolds were immersed in crosslinked HA in order for the coating to enhance biological performance...
September 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28939108/differential-response-to-doxorubicin-in-breast-cancer-subtypes-simulated-by-a-microfluidic-tumor-model
#8
Altug Ozcelikkale, Kyeonggon Shin, Victoria Noe-Kim, Bennett D Elzey, Zizheng Dong, Jian-Ting Zhang, Kwangmeyung Kim, Ick Chan Kwon, Kinam Park, Bumsoo Han
Successful drug delivery and overcoming drug resistance are the primary clinical challenges for management and treatment of cancer. The ability to rapidly screen drugs and delivery systems within physiologically relevant environments is critically important; yet is currently limited due to lack of appropriate tumor models. To address this problem, we developed the Tumor-microenvironment-on-chip (T-MOC), a new microfluidic tumor model simulating the interstitial flow, plasma clearance, and transport of the drug within the tumor...
September 19, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28938592/visible-light-sensitive-titanium-dioxide-nanoplatform-for-tumor-responsive-fe2-liberating-and-artemisinin-delivery
#9
Huijuan Zhang, Hongling Zhang, Xing Zhu, Xiaoge Zhang, Qianqian Chen, Jianjiao Chen, Lin Hou, Zhenzhong Zhang
Artemisinin is a kind of Fe(2+)-dependent drugs. Artemisinin and Fe(2+) co-transport systems can improve its anti-tumor effect. In this study, a visible light-sensitive nanoplatform (HA-TiO2-IONPs/ART) was developed. Detailed investigation demonstrated that HA-TiO2-IONPs/ART could realize Fe(2+) and artemisinin synchronous co-delivery and tumor-responsive release. This feature enhanced the anti-tumor efficiency of artemisinin significantly. In vitro results proved that hyaluronic acid modification could improve the biocompatibility, dispersion stability and cytophagy ability of nanocarriers...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937526/comparison-of-corneal-wetting-properties-of-different-dispersive-ophthalmic-viscosurgical-devices-an-optical-coherence-tomography-study
#10
Cagatay Karaca, Mustafa Ozkose, Metin Unlu, Duygu Gulmez Sevim, Ertugrul Mirza
PURPOSE: To compare corneal wetting performances of different dispersive ophthalmic viscosurgical devices. METHODS: Three different types of dispersive ophthalmic viscosurgical devices, hydroxypropyl methylcellulose %2 (HPMC), sodium hyaluronate %3-sodium chondroitin sulphate %4 (HACS), and sodium hyaluronate %3 (HA), were applied on corneal surfaces of 10 healthy volunteer subjects repeatedly at 3 different time points. Corneal wetting properties of the ophthalmic viscosurgical devices were compared qualitatively and quantitatively by anterior segment optical coherence tomography for 30 minutes...
September 20, 2017: Retina
https://www.readbyqxmd.com/read/28937277/injectable-viscoelastic-supplements-a-review-for-radiologists
#11
Dermot J Bowden, Caoimhe A Byrne, Abdullah Alkhayat, Stephen J Eustace, Eoin C Kavanagh
OBJECTIVE: Hyaluronic acid (HA) is increasingly used by musculoskeletal radiologists in the treatment of osteoarthritis (OA). Although the evidence base for its efficacy is controversial, it remains in common use. With initial evidence suggesting its efficacy in the knee, it is now offered for treating OA of the hip, ankle, and elsewhere. CONCLUSION: HA is available in a wide variety of preparations, which may vary in concentration and chemical composition. Clinicians offering intraarticular HA injection should be familiar with the common preparations available and the principal differences between them, its mechanism of action, and the profile of adverse effects associated with its use...
October 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28934876/comparison-of-intra-articular-injection-of-hyaluronic-acid-and-n-acetyl-cysteine-in-the-treatment-of-knee-osteoarthritis-a-pilot-study
#12
Mustafa Ozcamdalli, Abdulhamit Misir, Turan Bilge Kizkapan, Erdal Uzun, Fuat Duygulu, Cevat Yazici, Ibrahim Halil Kafadar
Objective To compare the relative effectiveness of intra-articular N-acetyl cysteine (NAC) and hyaluronic acid (HA) on pain, function and cartilage degradation markers in patients with mild to moderate knee osteoarthritis (OA). Design We prospectively conducted a clinical trial with 20 patients having a diagnosis of Kellgren-Lawrence grade 2-3 knee OA, and randomly allocated to the HA or NAC groups. Groups were matched on age, sex, and body mass index. Injections of 3-mL HA (Hylan G-F 20) or 3-mL NAC (Asist ampoule) were administered as a single shot...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28933697/enhanced-skin-regeneration-using-a-novel-amniotic-derived-tissue-graft
#13
Katie C Mowry, Paul P Bonvallet, Susan L Bellis
BACKGROUND: Chronic and recalcitrant wounds present a significant therapeutic challenge. Amniotic tissues contain many regenerative cytokines, growth factors, and extracellular matrix molecules including proteoglycans, hyaluronic acid, and collagens I, III, and IV. Dehydrated amnion/chorion grafts are currently used to treat a variety of wounds such as diabetic foot ulcers and burns. OBJECTIVE: The investigators hypothesized that processing methodologies, dehydration, and hypothermic processing and storage of amniotic tissues would affect overall quality of wound healing; they compared dehydrated amnion/chorion (dHACM) grafts to a novel hypothermically stored amniotic membrane (HSAM) graft in a full-thickness rat wound model...
September 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28932293/intra-articular-hyaluronic-acid-in-the-treatment-of-knee-osteoarthritis-a-canadian-evidence-based-perspective
#14
REVIEW
Mohit Bhandari, Raveendhara R Bannuru, Eric M Babins, Johanne Martel-Pelletier, Moin Khan, Jean-Pierre Raynauld, Renata Frankovich, Deanna Mcleod, Tahira Devji, Mark Phillips, Emil H Schemitsch, Jean-Pierre Pelletier
Osteoarthritis (OA) is a chronic condition characterized by a loss of joint cartilage and is a major cause of disability in Canada, with an estimated CN$195 billion annual cost. Knee OA leads to persistent pain and loss of function, and treatment goals primarily focus on symptom relief and retention of function. Intra-articular hyaluronic acid (IAHA) has therapeutic benefits, and numerous recently published meta-analyses (MAs) and commentaries have highlighted new evidence on the role of IAHA therapy for knee OA...
September 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28932127/an-in-vitro-model-of-renal-inflammation-after-ischemic-oxidative-stress-injury-nephroprotective-effects-of-a-hyaluronan-ester-with-butyric-acid-on-mesangial-cells
#15
Olga Baraldi, Francesca Bianchi, Viola Menghi, Andrea Angeletti, Anna Laura Croci Chiocchini, Maria Cappuccilli, Valeria Aiello, Giorgia Comai, Gaetano La Manna
BACKGROUND: Acute kidney injury, known as a major trigger for organ fibrosis and independent predictor of chronic kidney disease, is characterized by mesangial cell proliferation, inflammation and unbalance between biosynthesis and degradation of extracellular matrix. Therapeutic approaches targeting the inhibition of mesangial cell proliferation and matrix expansion may represent a promising opportunity for the treatment of kidney injury. An ester of hyaluronic acid and butyric acid (HB) has shown vasculogenic and regenerative properties in renal ischemic-damaged tissues, resulting in enhanced function recovery and minor degree of inflammation in vivo...
2017: Journal of Inflammation Research
https://www.readbyqxmd.com/read/28930907/hyaluronic-acid-and-other-conservative-treatment-options-for-osteoarthritis-of-the-ankle
#16
Amanda Stott
No abstract text is available yet for this article.
September 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/28929915/is-synovitis-detected-on-non-contrast-enhanced-magnetic-resonance-imaging-associated-with-serum-biomarkers-and-clinical-signs-of-effusion-data-from-the-osteoarthritis-initiative
#17
L A Deveza, V B Kraus, J E Collins, A Guermazi, F W Roemer, M C Nevitt, D J Hunter
OBJECTIVES: To determine the relationship between synovitis detected on non-contrast-enhanced (non-CE) magnetic resonance imaging (MRI), biochemical markers of inflammation, and clinical assessment of effusion in people with knee osteoarthritis (OA). METHOD: We examined data from the OA Biomarkers Consortium within the Osteoarthritis Initiative (n = 600). Non-CE MRIs were semi-quantitatively scored (grades 0-3) for severity of Hoffa synovitis and effusion synovitis...
September 20, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28928212/population-and-whole-genome-sequence-based-characterization-of-invasive-group-a-streptococci-recovered-in-the-united-states-during-2015
#18
Sopio Chochua, Ben J Metcalf, Zhongya Li, Joy Rivers, Saundra Mathis, Delois Jackson, Robert E Gertz, Velusamy Srinivasan, Ruth Lynfield, Chris Van Beneden, Lesley McGee, Bernard Beall
Group A streptococci (GAS) are genetically diverse. Determination of strain features can reveal associations with disease and resistance and assist in vaccine formulation. We employed whole-genome sequence (WGS)-based characterization of 1,454 invasive GAS isolates recovered in 2015 by Active Bacterial Core Surveillance and performed conventional antimicrobial susceptibility testing. Predictions were made for genotype, GAS carbohydrate, antimicrobial resistance, surface proteins (M family, fibronectin binding, T, R28), secreted virulence proteins (Sda1, Sic, exotoxins), hyaluronate capsule, and an upregulated nga operon (encodes NADase and streptolysin O) promoter (Pnga3)...
September 19, 2017: MBio
https://www.readbyqxmd.com/read/28927595/stability-and-binding-affinity-of-dna-chitosan-complexes-by-polyanion-competition
#19
Pei Lian Ma, Marc Lavertu, Françoise M Winnik, Michael D Buschmann
The stability of DNA/chitosan complexes upon exposure to hyaluronic acid, chondroitin sulfate, and heparin, was assessed by fluorescence spectroscopy to quantify DNA release. Only the highly charged heparin was found to release DNA from the complexes. Complex stability upon exposure to heparin increased with the degree of deacetylation and molecular weight of chitosan and with the ratio of chitosan amino groups to DNA phosphate groups (N/P ratio) in the complexes. Isothermal titration microcalorimetry revealed that among polyanions tested, only heparin has a binding affinity to chitosan approaching that of DNA and can therefore release DNA from the complexes...
November 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28927491/effectiveness-of-intranasal-sodium-hyaluronate-in-mitigating-adverse-effects-of-nasal-continuous-positive-airway-pressure-therapy
#20
(no author information available yet)
BACKGROUND: Nasal continuous positive airway pressure (CPAP) in moderate-to-severe cases of obstructive sleep apnea cancause nasal discomfort and other undesirable problems. OBJECTIVE: The aim of our study was to test the effects of sodium hyaluronate on nasal problems that patients experienced in their daily lives, sleepiness, nasal resistance to airflow, nasal mucociliary clearance, changes in inflammatory markers, and compliance to CPAP in three groups of patients with obstructive sleep apnea syndrome on CPAP therapy...
September 19, 2017: American Journal of Rhinology & Allergy
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