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https://www.readbyqxmd.com/read/28441078/comparison-of-0-3-hypotonic-and-isotonic-sodium-hyaluronate-eye-drops-in-the-treatment-of-experimental-dry-eye
#1
Ying Li, Lian Cui, Hyo Seok Lee, Yeon Soo Kang, Won Choi, Kyung Chul Yoon
PURPOSE: To compare the efficacy of 0.3% hypotonic and isotonic sodium hyaluronate (SH) eye drops in the treatment of experimental dry eye. METHODS: Experimental dry eye was established in female C57BL/6 mice by subcutaneous scopolamine injection and an air draft. The mice were divided into three groups (n = 15): control, preservative-free 0.3% isotonic SH, and preservative-free 0.3% hypotonic SH. The tear volume, tear film break-up time, and corneal fluorescein staining scores were measured 5 and 10 days after treatment...
April 25, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28441052/effects-of-hyaluronan-alone-or-in-combination-with-chondroitin-sulfate-and-n-acetyl-d-glucosamine-on-lipopolysaccharide-challenge-exposed-equine-fibroblast-like-synovial-cells
#2
Allison H Kilborne, Hayam Hussein, Alicia L Bertone
OBJECTIVE To investigate effects of hyaluronic acid (HA) or HA combined with chondroitin sulfate (CS) and N-acetyl-d-glucosamine (NAG) by use of a lipopolysaccharide (LPS) in vitro method. SAMPLE Monolayer cultures of synovial cells from 4 adult horses. PROCEDURES Synovial cell cultures were untreated or treated with HA alone or HA-CS-NAG for 24 hours, subsequently unchallenged or challenge-exposed with 2 LPS concentrations (20 and 50 ng/mL) for 2 hours, and retreated with HA or HA-CS-NAG for another 24 hours...
May 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28437845/a-small-specific-sized-hyaluronic-acid-ameliorates-alcoholic-liver-disease-ald-by-targeting-a-small-rna-new-hope-for-ald-therapy
#3
EDITORIAL
Yong He, Bin Gao
No abstract text is available yet for this article.
April 24, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28435559/intra-articular-hyaluronic-acid-ha-and-platelet-rich-plasma-prp-injection-versus-hyaluronic-acid-ha-injection-alone-in-patients-with-grade-iii-and-iv-knee-osteoarthritis-oa-a-retrospective-study-on-functional-outcome
#4
C Saturveithan, G Premganesh, S Fakhrizzaki, M Mahathir, K Karuna, K Rauf, H William, H Akmal, N Sivapathasundaram, K Jaspreet
Introduction: Intra-articular hyaluronic acid (HA) is widely utilized in the treatment of knee osteoarthritis whereas platelet rich plasma (PRP) enhances the regeneration of articular cartilage. This study analyses the efficacy of HA and PRP in grade III and IV knee osteoarthritis. Methodology: This is a cross sectional study with retrospective review of 64 patients (101 knees) which includes 56 knees injected with HA+ PRP, and 45 knees with HA only. Results: During the post six months International Knee Documentation Committee (IKDC) evaluation, HA+PRP group showed marked improvement of 24...
July 2016: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/28435213/comparison-of-0-2-and-0-18-hyaluronate-eye-drops-in-patients-with-moderate-to-severe-dry-eye-with-keratitis-or-keratoconjunctivitis
#5
Dorothea Groß, Marc Childs, Jean-Marie Piaton
PURPOSE: Comparison of efficacy and safety of 0.2% and 0.18% hyaluronic acid (HA) eye drops three times a day (tid) in patients with moderate to severe dry eye disease, related to keratitis or keratoconjunctivitis. PATIENTS AND METHODS: Prospective, multicenter, randomized, single-masked, phase IIIb, noninferiority study (0.2% HA vs 0.18% HA) in two parallel groups over a period of 84 days. N=70 patients were evaluated. Primary efficacy outcome was ocular surface (OS) staining change on day 35 (D35), compared to baseline...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28429999/beneficial-effects-of-oral-supplementation-with-ovoderm-on-human-skin-physiology-two-pilot-studies
#6
Andrés Aguirre, Erena Gil-Quintana, Marisa Fenaux, Sandra Erdozain, Itziar Sarria
Collagens and hyaluronic acid have long been used in pharmaceuticals and food supplements for the improvement of skin elasticity and hydration. These compounds provide the building blocks of the skin. Ovoderm is an oral supplement obtained from eggshells that contains naturally occurring collagen and glycosaminoglycans, such as hyaluronic acid. We evaluated the efficacy of Ovoderm on skin biophysical parameters related to cutaneous aging such as elasticity, hydration, and pigmentation. Two pilot studies were run to assess the effect of daily oral supplementation with 300 mg Ovoderm on skin parameters...
April 21, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28429341/hyalone%C3%A2-in-the-treatment-of-symptomatic-hip-oa-data-from-the-antiage-register-seven-years-of-observation
#7
A Migliore, U Massafra, B Frediani, E Bizzi, E Sinelnikov Yzchaki, G Gigliucci, M Cassol, S Tormenta
OBJECTIVE: Several studies on knee osteoarthritis suggest that the intra-articular administration of hyaluronic acid products may be a relevant option in the management of patients with persistent pain. The aim of this study is to report the data of efficacy of US-guided HyalOne®/Hyalubrix® 60 injections in a large population of patients with hip osteoarthritis, repeated at least 2 times per year for up to seven years. PATIENTS AND METHODS: This is a prospective, post-marketing, cohort study...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28428894/the-protective-role-of-hyaluronic-acid-in-cr-vi-induced-oxidative-damage-in-corneal-epithelial-cells
#8
Wei Wu, Hua Jiang, Xinnian Guo, Yu Wang, Shibo Ying, Lingfang Feng, Tao Li, Hailing Xia, Yixiao Zhang, Riping Chen, Tianhui Chen, Jianlin Lou
Cr(VI) exposure could produce kinds of intermediates and reactive oxygen species, both of which were related to DNA damage. Hyaluronan (HA) has impressive biological functions and was reported to protect corneal epithelial cells against oxidative damage induced by ultraviolet B, benzalkonium chloride, and sodium lauryl sulfate. So the aim of our study was to investigate HA protection on human corneal epithelial (HCE) cells against Cr(VI)-induced toxic effects. The HCE cell lines were exposed to different concentrations of K2Cr2O7 (1...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28426341/mydriatics-release-from-solid-and-semi-solid-ophthalmic-formulations-using-different-in-vitro-methods
#9
Silvia Pescina, Claudio Macaluso, Gloria Antonia Gioia, Cristina Padula, Patrizia Santi, Sara Nicoli
The aim of the present paper was the development of semisolid (hydrogels) and solid (film) ophthalmic formulations for the controlled release of two mydriatics: phenylephrine and tropicamide. The formulations - based on polyvinylalchol and hyaluronic acid - were characterized, and release studies were performed with three different in vitro set-ups, i.e. Franz-type diffusion cell, vial method and inclined plane; for comparison, a solution and a commercial insert, both clinically used to induce mydriasis, were evaluated...
April 20, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28423199/chemical-synthesis-of-modified-hyaluronic-acid-disaccharides
#10
Marco Mende, Martin Nieger, Stefan Bräse
Herein a chemical synthesis towards new modified hyaluronic acid oligomers for structure-related biological activity tests using only commercially available D-glucose and D-glucosamine hydrochloride is reported. The syntheses of various protected hyaluronic acid disaccharides bearing new functional groups at the C-6-position of the former β-D-glucuronic acid moiety are described. The orthogonal protecting group pattern creates a readily access to the appropriate higher oligomers. Also 1H NMR studies of the new derivatives are displayed, showing the effect of the group replacement on the intramolecular electronic environment...
April 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28422364/novel-technique-for-adhesion-barrier-insertion-by-using-cut-off-surgical-glove-fingers-in-laparoscopic-surgery
#11
Hitomi Nakagawa, Kazuaki Yoshimura, Kazuaki Nishimura, Toru Hachisuga
AIM: Laparoscopic surgery causes fewer postoperative adhesions than laparotomy and adhesion barriers are used to lessen the chance of adhesion. Sodium hyaluronate and carboxymethylcellulose (SH-CMC), a bioresorbable membrane, is effective in preventing adhesions. However, its properties make it difficult to insert the film into the abdominal cavity and to place it into the target area during laparoscopic surgeries. Here we report a novel technique for applying SH-CMC during laparoscopic surgeries by using cut-off surgical glove fingers...
April 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28420447/ck2-1-a-bone-morphogenetic-protein-receptor-type-ia-mimetic-peptide-repairs-cartilage-in-mice-with-destabilized-medial-meniscus
#12
Hemanth Akkiraju, Padma Pradeepa Srinivasan, Xian Xu, Xinqiao Jia, Catherine B Kirn Safran, Anja Nohe
BACKGROUND: Osteoarthritis (OA) of the knee involves degeneration of articular cartilage of the diarthrodial joints. Current treatment options temporarily relieve the joint pain but do not restore the lost cartilage. We recently designed a novel bone morphogenetic protein receptor type I (BMPRI) mimetic peptide, CK2.1, that activates BMPRIa signaling in the absence of bone morphogenetic protein (BMP). Our previous research demonstrated that CK2.1 induced chondrogenesis in vitro and in vivo; however, it is unknown if CK2...
April 18, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28416863/protective-effects-of-tetrahydrocurcumin-thc-on-fibroblast-and-melanoma-cell-lines-in-vitro-it-s-implication-for-wound-healing
#13
Mahendra Kumar Trivedi, Mayank Gangwar, Sambhu Charan Mondal, Snehasis Jana
The aim of this study was to investigate the role of tetrahydrocurcumin (THC) against various skin health parameters using in vitro human foreskin fibroblast and melanoma cell lines (i.e. HFF-1 and B16-F10). The study was assessed using cell viability by MTT assay, identification of extracellular matrix component in HFF-1 cell line (i.e. collagen, elastin and hyaluronic acid), melanin synthesis in B16-F10 cells, cell viability against UVB-induced stress in HFF-1 cells, and in vitro wound healing by the scratch assay...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28416171/the-comparison-of-knee-osteoarthritis-treatment-with-single-dose-bone-marrow-derived-mononuclear-cells-vs-hyaluronic-acid-injections
#14
Valdis Goncars, Eriks Jakobsons, Kristaps Blums, Ieva Briede, Liene Patetko, Kristaps Erglis, Martins Erglis, Konstantins Kalnberzs, Indrikis Muiznieks, Andrejs Erglis
OBJECTIVE: The aim of this study was to compare treatment methods of the knee joint degenerative osteoarthritis, using autologous bone marrow-derived mononuclear cells and hyaluronic acid injections and observe prevalence of adverse effects in both groups. MATERIALS AND METHODS: A prospective randomized controlled clinical trial was carried out. The analysis of pain and changes in osteoarthritis symptoms after a single intra-articular bone marrow-derived mononuclear cell injection into the knee joint in the Kellgren-Lawrence stage II-III osteoarthritis during the 12-month period were performed...
March 22, 2017: Medicina
https://www.readbyqxmd.com/read/28415029/multifunctional-nanoparticles-self-assembled-from-polyethylenimine-based-graft-polymers-as-efficient-anticancer-drug-delivery
#15
Jianqin Yan, Ting Su, Furong Cheng, Jun Cao, Hai Zhang, Bin He
Multiple functionalization of nanoparticles has attracted great interest in drug delivery. In this paper, polymeric amphiphiles of polyethylenimine (PEI) conjugated with methoxy poly(ethylene glycol) aldehyde (mPEG-CHO), poly(ε caprolactone) aldehyde (PCL-CHO) and pyrene-1-carboxaldehyde (Py-CHO) were synthesized via Schiff's reaction. The conjugates self-assembled into nanoparticles with pH-sensitivity to load anticancer drug doxorubicin (DOX), further coated with hyaluronic acid (HA) for tumor targeting...
February 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28414616/biphasic-finite-element-modeling-reconciles-mechanical-properties-of-tissue-engineered-cartilage-constructs-across-testing-platforms
#16
Gregory R Meloni, Matthew B Fisher, Brendan D Stoeckl, George R Dodge, Robert L Mauck
Cartilage tissue engineering is emerging as a promising treatment for osteoarthritis, and the field has progressed toward utilizing large animal models for proof of concept and preclinical studies. Mechanical testing of the regenerative tissue is an essential outcome for functional evaluation. However, testing modalities and constitutive frameworks used to evaluate in vitro grown samples differ substantially from those used to evaluate in vivo derived samples. To address this, we developed finite element (FE) models (using FEBio) of unconfined compression and indentation testing, modalities commonly used for such samples...
April 14, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28411478/a-supramolecular-nanoparticle-system-based-on-%C3%AE-cyclodextrin-conjugated-poly-l-lysine-and-hyaluronic-acid-for-co-delivery-of-gene-and-chemotherapy-agent-targeting-hepatocellular-carcinoma
#17
Qingqing Xiong, Mangmang Cui, Yang Bai, Yuanyuan Liu, Di Liu, Tianqiang Song
A novel supramolecular nanoparticle system with core-shell structure was designed based on β-cyclodextrin-conjugated poly-l-lysine (PLCD) and hyaluronic acid for co-delivery of gene and chemotherapy agent targeting hepatocellular carcinoma (HCC). PLCD was synthesized by the conjugation of monoaldehyde activated β-cyclodextrin with poly-l-lysine via Shiff's base reaction. Doxorubicin, as a model therapeutic drug, was included into the hydrophobic cavity of β-cyclodextrin in PLCD through host-guest interaction...
April 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28411450/activatable-near-infrared-dye-conjugated-hyaluronic-acid-based-nanoparticles-as-a-targeted-theranostic-agent-for-enhanced-fluorescence-ct-photoacoustic-imaging-guided-photothermal-therapy
#18
Xiaolong Liang, Lei Fang, Xiaoda Li, Xu Zhang, Fan Wang
Targeted theranostic nano-system integrating functions of both diagnosis and therapy shows great potential for improving diagnosis and therapeutic efficacy. Herein, multifunctional nanoparticle based on activatable hyaluronic acid (HA) conjugating two near-infrared (NIR) dyes of Cy5.5 and IR825 was successfully designed and fabricated, and simultaneously used as a carrier for encapsulating perfluorooctylbromide (PFOB). In this system, PFOB showed good capability to absorb the X-rays, Cy5.5 on the outer surface acted as a fluorescent dye activatable by hyaluronidases (Hyals) in the tumor, and IR825 in the core as a photothermal agent...
July 2017: Biomaterials
https://www.readbyqxmd.com/read/28409101/microdrilling-surgery-augmented-with-intra-articular-bone-marrow-aspirate-concentrate-platelet-rich-plasma-and-hyaluronic-acid-a-technique-for-cartilage-repair-in-the-knee
#19
Joseph E Broyles, M Adaire O'Brien, M Patrick Stagg
The ideal treatment of large full-thickness chondral lesions in the knee, especially "kissing lesions" and osteoarthritis, has not been determined. Microdrilling surgery augmented with injections of peripheral blood stem cells and hyaluronic acid has been used to treat patients with a wide range of articular cartilage disease including patients with bipolar lesions and joint space narrowing. Excellent results in this difficult patient population have been reported, and second-look biopsy has shown repair tissue very similar to native hyaline cartilage...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28407433/spatiotemporal-evolution-of-the-wound-repairing-process-in-a-3d-human-dermis-equivalent
#20
Bernadette Lombardi, Costantino Casale, Giorgia Imparato, Francesco Urciuolo, Paolo Antonio Netti
Several skin equivalent models have been developed to investigate in vitro the re-epithelialization process occurring during wound healing. Although these models recapitulate closure dynamics of epithelial cells, they fail to capture how a wounded connective tissue rebuilds its 3D architecture until the evolution in a scar. Here, the in vitro tissue repair dynamics of a connective tissue is replicated by using a 3D human dermis equivalent (3D-HDE) model composed of fibroblasts embedded in their own extracellular matrix (ECM)...
April 13, 2017: Advanced Healthcare Materials
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