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https://www.readbyqxmd.com/read/29774962/maternal-regulation-of-the-infant-s-hpa-axis-stress-response-seymour-gig-levine-s-legacy-to-neuroendocrinology
#1
REVIEW
Deborah Suchecki
Thirty years ago, Seymour 'Gig' Levine published a serendipitous, yet, seminal finding on the regulatory role of maternal presence on the corticosterone stress response of neonatal rats, during the developmental period know as stress hyporesponsive period. At the same time, his group of students also studied the stress response of infant monkeys to maternal separation, as a means to understand the stressful nature of disruptions of attachment to the primary caregiver. Gig and his group of students and collaborators, mainly in the USA and the Netherlands, investigated how initial social relationships buffer the stress response of non-human primate and rodent infants...
May 18, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29773148/personalized-treatment-outcomes-in-patients-with-somatoform-disorder-a-concept-mapping-study
#2
Sonja Klemm, Saskia van Broeckhuysen-Kloth, Sanne van Vliet, Lummy Oosterhuis, Rinie Geenen
OBJECTIVE: From a patient-centered perspective, treatment outcome measures in somatoform disorder need to be (1) personalized to the patient, (2) fit core problems that are targeted in therapy, and (3) reflect one's ability to adapt and self-manage anticipated deterioration. The aim of this study was to identify an encompassing set of treatment outcome variables in patients with somatoform disorder. METHODS: In-depth interviews yielded a comprehensive overview of 60 treatment outcomes that were sorted in a card sorting task according to similarity of meaning by 30 patients...
June 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29770150/effect-of-cathodal-transcranial-direct-current-stimulation-on-a-child-with-involuntary-movement-after-hypoxic-encephalopathy
#3
Mayumi Nagai, Naofumi Tanaka, Yutaka Oouchida, Shin-Ichi Izumi
The aim of the study was to investigate the effect of cathodal transcranial direct current stimulation to the supplementary motor area to inhibit involuntary movements of a child. An 8-year-old boy who developed hypoxic encephalopathy after asphyxia at the age of 2 had difficulty in remaining standing without support because of involuntary movements. He was instructed to remain standing with his plastic ankle-foot orthosis for 10 s at three time points by leaning forward with his forearms on a desk. He received cathodal or sham transcranial direct current stimulation to the supplementary motor area at 1 mA for 10 min...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/29768527/approaching-patients-with-hyperreflectivity-and-perplexity-an-empirical-qualitative-investigation
#4
Sidse Marie Arnfred, Paul Møller, Annette Sofie Davidsen
OBJECTIVE: Perplexity and hyperreflectivity are considered important aspects of self-disorders in patients with schizophrenia, yet knowledge of the appropriate psychotherapy for these patients is sparse. We aimed to explore how phenomenological psychologists or psychiatrists described their approach to these patients and their own emotional response when hyperreflectivity and perplexity emerged in therapy or consultations. METHODS: Four e-mail interviews with experienced clinical researchers within the field of phenomenology and schizophrenia were examined using a double hermeneutic qualitative analysis...
May 14, 2018: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/29767366/expression-profiling-of-differentially-regulated-genes-in-fanconi-anemia
#5
Binita Zipporah E, Kavitha Govarthanan, Pavithra Shyamsunder, Rama S Verma
Gene expression analysis mainly helps to study gene quantification methods by using various downstream detection approaches like imaging, amplification, probe hybridization, or sequencing. With respect to DNA, which is less static, mRNA levels vary over time, between cell types under divergent conditions. Gene expression analysis is principally focused on determination of mRNA levels transcribed from DNA. DNA microarrays are one of the robust and powerful tools to detect changes in multiple transcripts in larger cohorts in parallel...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29765713/different-packing-motifs-of-isomeric-e-n-halo-phenyl-methyl-idene-n-methyl-2-thio-phen-2-yl-acetohydrazides-controlled-by-c-h%C3%A2-o-inter-actions
#6
Laura N F Cardoso, Thais C M Noguiera, James L Wardell, Marcus V N de Souza, William T A Harrison
The crystal structures of three isomeric ( E )- N '-(chloro-phenyl-methyl-idene)- N -methyl-2-(thio-phen-2-yl)acetohydrazides (C14 H13 ClN2 OS) are described, with the Cl atom in ortho (I), meta (III) and para (IV) positions in the benzene ring. The ortho -bromo derivative (II) (C14 H13 BrN2 OS), which is isostructural with its chloro congener (I), is also reported. Mol-ecules (I)-(III) have similar conformations, which approximate to l-shapes, as indicated by their N-C-C-Ct (t = thio-phene) torsion angles of -90...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29759022/compassion-focused-therapy-for-trauma-in-people-with-intellectual-disabilities-a-conceptual-review
#7
Megan Cowles, Cathy Randle-Phillips, Andrew Medley
Trauma exposure and post-traumatic stress disorder are more prevalent in people with intellectual disabilities (PWID) than in the general population, yet the evidence base for trauma interventions in this population is sparse. Compassion-focused therapy (CFT) may be particularly well-suited to PWID for a number of reasons, including its adaptability to different developmental levels. PWID are more likely to have issues with self-relating (e.g. shame and self-criticism) and attachment than the general population, two issues that are compounded by trauma and which CFT explicitly seeks to address...
January 1, 2018: Journal of Intellectual Disabilities: JOID
https://www.readbyqxmd.com/read/29755840/treatment-of-mallet-finger-deformity-with-a-modified-palmaris-longus-tendon-graft-through-a-bone-tunnel
#8
Zengbing Liu, Kai Ma, Dong Huang
OBJECTIVE: To investigate the clinical effect of treating mallet finger deformity using a modified palmaris longus tendon graft through a bone tunnel. METHODS: Altogether, 21 patients with mallet finger deformity (16 men, 5 women; average age 31 years, range 19-47 years) were treated with a modified palmaris longus tendon graft through a bone tunnel during 18 months (2014-2016). Four index fingers, seven middle fingers, eight ring fingers, and two little fingers were treated for four cutting injuries, eleven finger sprains, four crush injuries, and two twist injuries (7 open and 14 closed injuries)...
2018: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/29755392/psychometric-properties-of-the-chinese-version-of-the-brief-borderline-symptom-list-in-undergraduate-students-and-clinical-patients
#9
Huihui Yang, Xiaoxia Lei, Mingtian Zhong, Qi Zhou, Yu Ling, Martin Jungkunz, Jinyao Yi
The brief version of the Borderline Symptom List (BSL-23) is a self-rated scale developed from the initial 95-item version of Borderline Symptom List (BSL-95). The current study aimed to evaluate the psychometric properties of the Chinese version of the BSL-23. A total of 570 undergraduate students and 323 clinical patients completed the BSL-23, the borderline subscale of the Personality Diagnostic Questionnaire (PDQ-4+), the Center for Epidemiologic Studies Depression Scale (CES-D), the Barratt Impulsiveness Scale, 11th version (BIS-11), the Childhood Trauma Questionnaire (CTQ) and the Attachment Style Questionnaire (ASQ)...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29751243/adult-attachment-representations-and-depressive-symptoms-a-meta-analysis
#10
REVIEW
Or Dagan, Christopher R Facompré, Kristin Bernard
BACKGROUND: Attachment theory has long argued that insecure and disorganized attachment representations are associated with vulnerability to psychopathology in general, and depressive symptoms in particular. However, studies assessing the link between insecure and disorganized attachment and depressive symptoms report inconsistent results. The primary aim of this meta-analysis was to examine the extent to which adult attachment representations are associated with depressive symptoms. METHODS: We conducted a literature search for published studies using PsycINFO, MEDLINE, and ProQuest in March 2017, identifying 55 samples (N = 4,386)...
April 25, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29746695/finding-the-forgotten-motivating-military-veterans-to-register-with-a-primary-healthcare-practice
#11
Alan Finnegan, Robin Jackson, Robin Simpson
Introduction: In the UK, primary healthcare practices choose from a series of Read codes to detail certain characteristics onto a patient's medical documentation. One of these codes is for military veterans indicating a history relating to military service. However, veterans are poor at seeking help, with research indicating that this code is only applied in 7.9% of cases. Clinical staff have a clear role in motivating veterans to declare their ex-Forces status or register with a primary healthcare center...
May 9, 2018: Military Medicine
https://www.readbyqxmd.com/read/29733645/aromatic-based-design-of-highly-active-and-noncalcemic-vitamin-d-receptor-agonists
#12
Pranjal Gogoi, Samuel Seoane, Rita Sigueiro, Thierry Guiberteau, Miguel A Maestro, Roman Perez-Fernandez, Natacha Rochel, Antonio Mouriño
1We report the design, synthesis, biological evaluation and structural analysis of a new class of vitamin D analogs that possess an aromatic m-phenylene D-ring and an alkyl chain replacing the C-ring. A key feature of the synthetic strategy is a stereoselective Pd-catalyzed construction of the triene system in aqueous medium that allows the rapid preparation of small amounts of VDR ligands for biological screening. Analogs with the shorter (2a) and longer (2d, 2e) side chains attached to the triene system have no calcemic activity...
May 7, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29733529/sensor-based-gait-analysis-in-atypical-parkinsonian-disorders
#13
Cecilia Raccagni, Heiko Gaßner, Sabine Eschlboeck, Sylvia Boesch, Florian Krismer, Klaus Seppi, Werner Poewe, Bjoern M Eskofier, Juergen Winkler, Gregor Wenning, Jochen Klucken
BACKGROUND AND OBJECTIVES: Gait impairment and reduced mobility are typical features of idiopathic Parkinson's disease (iPD) and atypical parkinsonian disorders (APD). Quantitative gait assessment may have value in the diagnostic workup of parkinsonian patients and as endpoint in clinical trials. The study aimed to identify quantitative gait parameter differences in iPD and APD patients using sensor-based gait analysis and to correlate gait parameters with clinical rating scales. SUBJECTS AND METHODS: Patients with iPD and APD including Parkinson variant multiple system atrophy and progressive supranuclear palsy matched for age, gender, and Hoehn and Yahr (≤3) were recruited at two Movement Disorder Units and assessed using standardized clinical rating scales (MDS-UPDRS-3, UMSARS, PSP-RS)...
May 7, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29731417/social-touch-and-human-development
#14
Carissa J Cascio, David Moore, Francis McGlone
Social touch is a powerful force in human development, shaping social reward, attachment, cognitive, communication, and emotional regulation from infancy and throughout life. In this review, we consider the question of how social touch is defined from both bottom-up and top-down perspectives. In the former category, there is a clear role for the C-touch (CT) system, which constitutes a unique submodality that mediates affective touch and contrasts with discriminative touch. Top-down factors such as culture, personal relationships, setting, gender, and other contextual influences are also important in defining and interpreting social touch...
April 24, 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29716468/-observation-of-attachment-disorder-symptoms-in-middle-childhood
#15
Alexandra Iwanski, Peter Zimmermann
Observation of Attachment Disorder Symptoms in Middle Childhood Attachment in childhood is mainly assessed by observation. In contrast, assessment of attachment disorder symptoms (RAD) is mainly based on caregiver reports. The present study uses a newly developed observation tool (Coding of Attachment Disorder Behavior in Children; Iwanski u. Zimmermann, 2013) to assess attachment disorder symptoms in a group of school-aged children from a risk group for the development of attachment disorder symptoms and non-clinical controls...
May 2018: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/29716463/-attachment-and-externalizing-behavior-problems-in-primary-school-children-with-adhd
#16
Sebastian Franke, Rüdiger Kißgen
Attachment and Externalizing Behavior Problems in Primary School Children with ADHD When examining children with ADHD, attachment research does not usually differentiate between the different clinical pictures within the disorder. This study examines attachment and ADHD in children who display a simple or unspecified form of ADHD, in order to be able to draw specific conclusions about this particular group. Attachment, ADHD symptoms as well as externalizing behavior problems were assessed from 93 children aged five to nine years, 48 of whom had an ADHD diagnosis...
May 2018: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/29706162/course-of-disinhibited-social-engagement-disorder-from-early-childhood-to-early-adolescence
#17
Katherine L Guyon-Harris, Kathryn L Humphreys, Nathan A Fox, Charles A Nelson, Charles H Zeanah
OBJECTIVE: Disinhibited social engagement disorder (DSED) is poorly understood beyond early childhood. The course of DSED signs in a sample of children who experienced severe, early deprivation from early childhood to early adolescence was examined using variable-centered (linear mixed modeling) and person-centered (growth mixture modeling) approaches. METHOD: The study included 124 children with a history of institutional care from a randomized controlled trial of foster care as an alternative to institutional care and 69 community comparison children matched by age and sex...
May 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29706157/what-happens-to-disinhibited-social-engagement-disorder-over-time
#18
EDITORIAL
Helen Minnis
Disinhibited social engagement disorder (DSED) is one of the most intriguing syndromes in child and adolescent psychiatry but also one of the least understood. We know little about its developmental course in different groups of children, so I was delighted to see the incisive longitudinal work from the Bucharest Early Intervention Study by Guyon-Harris and colleagues.1 My own interest in DSED was sparked back in the early 1990s, when a travel bug had taken me to Guatemala and I had found a job in an orphanage...
May 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29706092/normal-feline-behaviour-%C3%A2-and-why-problem-behaviours-develop
#19
John Bradshaw
Practical relevance: Cats are descended from a solitary, territorial ancestor, and while domestication has reduced their inherited tendency to be antagonistic towards all animals larger than their typical prey, they still place more reliance on the security of their territory than on psychological attachments to people or other cats, the exact opposite to dogs. Many feline problem behaviours stem from perceived threats to this security, often due to conflicts with other cats. Others are more developmental in origin, often caused by inadequate exposure to crucial stimuli, especially people, during the socialisation period...
May 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29704684/improved-molecular-platform-for-the-gene-therapy-of-rare-diseases-by-liver-protein-secretion
#20
REVIEW
Mickael Quiviger, Aristeidis Giannakopoulos, Sebastien Verhenne, Corinne Marie, Eleana F Stavrou, Karen Vanhoorelbeke, Zsuzsanna Izsvák, Simon F De Meyer, Aglaia Athanassiadou, Daniel Scherman
Many rare monogenic diseases are treated by protein replacement therapy, in which the missing protein is repetitively administered to the patient. However, in several cases, the missing protein is required at a high and sustained level, which renders protein therapy far from being adequate. As an alternative, a gene therapy treatment ensuring a sustained effectiveness would be particularly valuable. Liver is an optimal organ for the secretion and systemic distribution of a therapeutic transgene product. Cutting edge non-viral gene therapy tools were tested in order to produce a high and sustained level of therapeutic protein secretion by the liver using the hydrodynamic delivery technique...
April 25, 2018: European Journal of Medical Genetics
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