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https://www.readbyqxmd.com/read/28935390/ask-the-question-screening-for-postpartum-mood-and-anxiety-disorders-in-pediatric-primary-care
#1
Stacy Kurtz, Jack Levine, Marcy Safyer
Postpartum mood and anxiety disorders (PMADs) are a significant source of toxic stress for young children and can disrupt developing brain architecture resulting in long-lasting deleterious effects. Thus, screening for PMADs must be considered as an essential task of a pediatric primary care provider (PCP) and the pediatric medical home. Problems in parenting capacity in mothers with PMADs can lead to disorders in attachment and a range of other emotional and developmental challenges for a young child. Therefore, all PCP office visits with mothers should include surveillance as well as formal screening at regular, pre-determined intervals...
September 18, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28934368/a-single-danio-rerio-hars-gene-encodes-both-cytoplasmic-and-mitochondrial-histidyl-trna-synthetases
#2
Ashley L Waldron, Sara Helms Cahan, Christopher S Franklyn, Alicia M Ebert
Histidyl tRNA Synthetase (HARS) is a member of the aminoacyl tRNA synthetase (ARS) family of enzymes. This family of 20 enzymes is responsible for attaching specific amino acids to their cognate tRNA molecules, a critical step in protein synthesis. However, recent work highlighting a growing number of associations between ARS genes and diverse human diseases raises the possibility of new and unexpected functions in this ancient enzyme family. For example, mutations in HARS have been linked to two different neurological disorders, Usher Syndrome Type IIIB and Charcot Marie Tooth peripheral neuropathy...
2017: PloS One
https://www.readbyqxmd.com/read/28934078/abnormal-white-matter-microstructure-among-early-adulthood-smokers-a-tract-based-spatial-statistics-study
#3
Shuangkun Wang, Long Zuo, Tao Jiang, Peng Peng, Shuilian Chu, Dan Xiao
Objectives Cigarette smoking is an important risk factor of central nervous system diseases. However, the white matter (WM) integrity of early adulthood chronic smokers has not been attached enough importance to as it deserves, and the relationship between the chronic smoking effect and the WM is still unclear. The purpose of this study was to investigate whole - brain WM microstructure of early adulthood smokers and explore the structural correlates of behaviorally relevant features of the disorder. Methods We compared multiple DTI-derived indices, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD), between early adulthood smokers (n = 19) and age-, education- and gender-matched controls (n = 23) using a whole-brain tract-based spatial statistics approach...
September 21, 2017: Neurological Research
https://www.readbyqxmd.com/read/28931924/chimeric-14-3-3-proteins-for-unraveling-interactions-with-intrinsically-disordered-partners
#4
Nikolai N Sluchanko, Kristina V Tugaeva, Sandra J Greive, Alfred A Antson
In eukaryotes, several "hub" proteins integrate signals from different interacting partners that bind through intrinsically disordered regions. The 14-3-3 protein hub, which plays wide-ranging roles in cellular processes, has been linked to numerous human disorders and is a promising target for therapeutic intervention. Partner proteins usually bind via insertion of a phosphopeptide into an amphipathic groove of 14-3-3. Structural plasticity in the groove generates promiscuity allowing accommodation of hundreds of different partners...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928224/chronic-diseases-as-predictors-of-labour-market-attachment-after-participation-in-subsidised-re-employment-programme-a-6-year-follow-up-study
#5
Chioma A Nwaru, Laura Peutere, Mika Kivimäki, Jaana Pentti, Jussi Vahtera, Pekka J Virtanen
BACKGROUND: Little is known about the work patterns of re-employed people. We investigated the labour market attachment trajectories of re-employed people and assessed the influence of chronic diseases on these trajectories. METHODS: The study was based on register data of 18 944 people (aged 18-60 years) who participated in a subsidised re-employment programme in Finland. Latent class growth analysis with zero-inflated Poisson was used to model the labour market attachment trajectories over a 6-year follow-up time...
September 19, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28928219/o2-sensing-associated-glycosylation-exposes-the-f-box-combining-site-of-the-dictyostelium-skp1-subunit-in-e3-ubiquitin-ligases
#6
M Osman Sheikh, David Thieker, Gordon Chalmers, Christopher M Schafer, Mayumi Ishihara, Parastoo Azadi, Robert J Woods, John N Glushka, Brad Bendiak, James H Prestegard, Christopher M West
Skp1 is a conserved protein linking cullin-1 to F-box proteins in SCF (Skp1-Cullin1-F-box) E3 ubiquitin ligases, which modify protein substrates with polyubiquitin chains that typically target them for 26S proteasome-mediated degradation. In Dictyostelium (a social amoeba), Toxoplasma gondii (the agent for human toxoplasmosis), and other protists, Skp1 is regulated by a unique pentasaccharide attached to hydroxylated Pro-143 within its C-terminal F-box binding domain. Prolyl hydroxylation of Skp1 contributes to O2-dependent Dictyostelium development, but full glycosylation at that position is required for optimal O2 sensing...
September 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28927773/-school-refusal-psychopathological-profiles-of-adolescents-followed-in-a-day-hospital-setting
#7
J Romani, S Campredon, D Da Fonseca
INTRODUCTION: School refusal appeared when formal education became compulsory in 1882, with the Jules Ferry laws. In international psychiatric classifications, school refusal does not appear as a diagnosis by itself, but it co-exists and is inherent to the symptoms of other psychiatric conditions, in particular of anxiety and depressive disorders. The main goal of this study was to describe psychopathological disorders in teenagers presenting school refusal followed in a day hospital setting...
September 15, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28927410/the-search-for-relevant-outcome-measures-for-cost-utility-analysis-of-systemic-family-interventions-in-adolescents-with-substance-use-disorder-and-delinquent-behavior-a-systematic-literature-review
#8
REVIEW
S Schawo, C Bouwmans, E van der Schee, V Hendriks, W Brouwer, L Hakkaart
PURPOSE: Systemic family interventions have shown to be effective in adolescents with substance use disorder and delinquent behavior. The interventions target interactions between the adolescent and involved systems (i.e. youth, family, peers, neighbors, school, work, and society). Next to effectiveness considerations, economic aspects have gained attention. However, conventional generic quality of life measures used in health economic evaluations may not be able to capture the broad effects of systemic interventions...
September 19, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28915904/tiga-cub-manualised-psychoanalytic-child-psychotherapy-versus-treatment-as-usual-for-children-aged-5-11-years-with-treatment-resistant-conduct-disorders-and-their-primary-carers-study-protocol-for-a-randomised-controlled-feasibility-trial
#9
Elizabeth Edginton, Rebecca Walwyn, Kayleigh Burton, Robert Cicero, Liz Graham, Sadie Reed, Sandy Tubeuf, Maureen Twiddy, Alex Wright-Hughes, Lynda Ellis, Dot Evans, Tom Hughes, Nick Midgley, Paul Wallis, David Cottrell
BACKGROUND: The National Institute for Health and Care Excellence (NICE) recommends evidence-based parenting programmes as a first-line intervention for conduct disorders (CD) in children aged 5-11 years. As these are not effective in 25-33% of cases, NICE has requested research into second-line interventions. Child and Adolescent Psychotherapists (CAPTs) address highly complex problems where first-line treatments have failed and there have been small-scale studies of Psychoanalytic Child Psychotherapy (PCP) for CD...
September 15, 2017: Trials
https://www.readbyqxmd.com/read/28915376/psychometric-properties-of-the-postpartum-bonding-questionnaire-and-correlates-of-mother-infant-bonding-impairment-in-italian-new-mothers
#10
Alessandra Busonera, Stefania Cataudella, Jessica Lampis, Marco Tommasi, Giulio Cesare Zavattini
OBJECTIVE: impaired maternal bonding is a risk factor for problems with infant well-being and development. The investigation of perinatal variables related to disorders of the mother-infant relationship as well as the administration of reliable and valid screening tools to new mothers in the postpartum can help identify early signs of a disturbed mother-child relationship. The Postpartum Bonding Questionnaire (PBQ) has been shown to be a valid screening instrument, but its dimensional structure is still controversial...
September 1, 2017: Midwifery
https://www.readbyqxmd.com/read/28912798/comparative-genomic-analysis-of-the-human-gut-microbiome-reveals-a-broad-distribution-of-metabolic-pathways-for-the-degradation-of-host-synthetized-mucin-glycans-and-utilization-of-mucin-derived-monosaccharides
#11
Dmitry A Ravcheev, Ines Thiele
The colonic mucus layer is a dynamic and complex structure formed by secreted and transmembrane mucins, which are high-molecular-weight and heavily glycosylated proteins. Colonic mucus consists of a loose outer layer and a dense epithelium-attached layer. The outer layer is inhabited by various representatives of the human gut microbiota (HGM). Glycans of the colonic mucus can be used by the HGM as a source of carbon and energy when dietary fibers are not sufficiently available. Both commensals and pathogens can utilize mucin glycans...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28905880/mutations-in-rars-cause-a-hypomyelination-disorder-akin-to-pelizaeus-merzbacher-disease
#12
Michael Nafisinia, Nara Sobreira, Lisa Riley, Wendy Gold, Birgit Uhlenberg, Claudia Weiß, Corinne Boehm, Kristina Prelog, Robert Ouvrier, John Christodoulou
Pelizaeus-Merzbacher disease (PMD) is a rare Mendelian disorder characterised by central nervous system hypomyelination. PMD typically manifests in infancy or early childhood and is caused by mutations in proteolipid protein-1 (PLP1). However, variants in several other genes including gap junction protein gamma 2 (GJC2) can also cause a similar phenotype and are referred to PMD-like disease (PMLD). Whole-exome sequencing in two siblings presenting with clinical symptoms of PMD revealed a homozygous variant in the arginyl-tRNA synthetase (RARS) gene: NM_002887...
October 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28903103/change-of-unresolved-attachment-in-borderline-personality-disorder-rct-study-of-transference-focused-psychotherapy
#13
Anna Buchheim, Susanne Hörz-Sagstetter, Stephan Doering, Michael Rentrop, Peter Schuster, Peter Buchheim, Dan Pokorny, Melitta Fischer-Kern
No abstract text is available yet for this article.
September 14, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28899753/precise-gene-editing-of-chicken-na-h-exchange-type-1-chnhe1-confers-resistance-to-avian-leukosis-virus-subgroup-j-alv-j
#14
Hong Jo Lee, Kyung Youn Lee, Kyung Min Jung, Kyung Je Park, Ko On Lee, Jeong-Yong Suh, Yongxiu Yao, Venugopal Nair, Jae Yong Han
Avian leukosis virus subgroup J (ALV-J), first isolated in the late 1980s, has caused economic losses to the poultry industry in many countries. As all chicken lines studied to date are susceptible to ALV infection, there is enormous interest in developing resistant chicken lines. The ALV-J receptor, chicken Na(+)/H(+) exchange 1 (chNHE1) and the critical amino acid sequences involved in viral attachment and entry have already been characterized. However, there are no reported attempts to induce resistance to the virus by targeted genome modification of the receptor sequences...
September 9, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28895183/self-concept-in-institutionalized-children-with-disturbed-attachment-the-mediating-role-of-exploratory-behaviours
#15
V S Vacaru, P S Sterkenburg, C Schuengel
BACKGROUND: Self-concept is seen as both an outcome of sociocognitive and emotional development, and a factor in social and mental health outcomes. Although the contribution of attachment experiences to self-concept has been limited to quality of primary attachment relationships, little is known of the effects of disturbed attachment on self-concept in institutionalized children. Thus, the current study examined associations between disturbed attachment behaviours in institutionalized children and self-concept, testing limited exploration as an explanatory factor...
September 11, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28883918/predicting-intolerance-of-uncertainty-in-individuals-with-eating-disorder-symptoms
#16
Lot C Sternheim, Martin Fisher, Amy Harrison, Rosamond Watling
BACKGROUND: Intolerance of Uncertainty (IU) is recognized for its contribution to various psychopathologies, in particular anxiety and depression. Studies highlight the relevance of IU for Eating Disorders (EDs) however, potential factors contributing to IU in EDs remain unstudied. METHODS: Three hundred and forty-nine women with ED symptoms and 214 individuals without ED symptoms were recruited and compared on levels of IU, insecure (anxious and avoidant) attachment styles, extraversion and openness...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/28882085/psychotherapeutic-and-vocational-interventions-among-young-adults-with-work-disability-due-to-mental-disorders-in-finland
#17
Pauliina Mattila-Holappa, Matti Joensuu, Kirsi Ahola, Teija Kivekäs, Mika Kivimäki, Aki Koskinen, Marianna Virtanen
Backround: Little is known about treatment and rehabilitation received and planned among young adults with work disability due to a mental disorder. AIMS: To examine the implemented psychotherapeutic and vocational interventions and treatment plans among young adults with work disability due to a mental disorder. MATERIAL AND METHODS: Data were collected from medical records of young Finnish adults aged 18-34 with a long-term work disability history due to a mental disorder (N = 1163)...
September 7, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28880415/pregnant-substance-abusers-in-voluntary-and-coercive-treatment-in-norway-therapists-reflections-on-change-processes-and-attachment-experiences
#18
Siv Merete Myra, Edle Ravndal, Vigdis Wie Torsteinsson, Anne Kyong Sook Øfsti
AIMS AND OBJECTIVES: To explore therapists' discourses on treatment processes, when working with pregnant substance abusers in voluntary and coercive treatment, and looking for the clinical implications of these discourses. BACKGROUND: Treatment of Substance Use Disorder (SUDs) faces many challenges. One is pregnancy and motherhood, which are vulnerable and complex processes. The literature emphasizes lack of optimal and knowledge-based treatment for this group...
September 7, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28877484/effect-of-a-paramagnetic-spin-label-on-the-intrinsically-disordered-peptide-ensemble-of-amyloid-%C3%AE
#19
Sukanya Sasmal, James Lincoff, Teresa Head-Gordon
Paramagnetic relaxation enhancement is an NMR technique that has yielded important insight into the structure of folded proteins, although the perturbation introduced by the large spin probe might be thought to diminish its usefulness when applied to characterizing the structural ensembles of intrinsically disordered proteins (IDPs). We compare the computationally generated structural ensembles of the IDP amyloid-β42 (Aβ42) to an alternative sequence in which a nitroxide spin label attached to cysteine has been introduced at its N-terminus...
September 5, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28870203/the-dlgap-family-neuronal-expression-function-and-role-in-brain-disorders
#20
REVIEW
Andreas H Rasmussen, Hanne B Rasmussen, Asli Silahtaroglu
The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses. Glutamate is released from the presynaptic membrane into the synaptic cleft. Across the synaptic cleft glutamate binds to both ion channels and metabotropic glutamate receptors at the postsynapse, which expedite downstream signalling in the neuron. The postsynaptic density, a highly specialized matrix, which is attached to the postsynaptic membrane, controls this downstream signalling. The postsynaptic density also resets the synapse after each synaptic firing...
September 4, 2017: Molecular Brain
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