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https://www.readbyqxmd.com/read/28429674/targeting-the-role-of-lipoprotein-a-in-stroke
#1
Mahdi Garelnabi, Zahra Mazhar, Andrew Hughes
Stroke is the third leading cause of death in the United States, behind only heart disease and cancer, with over 140,000 associated deaths per year. Considerable research is ongoing to examine the role of modifiable risk factors which may cause or contribute to a stroke occurring. Although age and family history are generally considered to be major risk factors, there are several modifiable and non-modifiable risk factors that are linked to the pathogenesis of a stroke. Lipoprotein (a), or Lp(a), is a type of low-density lipoprotein containing an integral apoB100 component with an attached ApoA1 isoform via a disulfide linkage...
April 21, 2017: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/28425095/psychomotor-tremor-and-proprioceptive-control-problems-in-current-and-former-stimulant-drug-users-an-accelerometer-study-of-heavy-users-of-amphetamine-mdma-and-other-recreational-stimulants
#2
Luke A Downey, Brenda Tysse, Talitha C Ford, Angela C Samuels, Rory P Wilson, Andrew C Parrott
The recreational use of various stimulant drugs has been implicated in the development of movement disorders through dysregulation of the dopaminergic and serotoninergic neurotransmitter systems. The present study investigated psychomotor differences in current and former recreational stimulant drug users compared with nonusing controls. Sixty participants comprised 3 groups: 20 current stimulant drug users (CSUs; 11 men, aged 31.4 ± 9.1 years), 20 former stimulant drug users (FSUs; 5 men, aged 39.1 ± 8.5 years), and 20 nonuser controls (NUCs; 5 men, aged 35...
April 19, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28420317/the-role-of-coherence-of-mind-and-reflective-functioning-in-understanding-binge-eating-disorder-and-co-morbid-overweight
#3
Hilary Maxwell, Giorgio A Tasca, Renee Grenon, Megan Faye, Kerri Ritchie, Hany Bissada, Louise Balfour
Coherence of mind and reflective functioning may impact negative affect and interpersonal functioning over and above the effects of symptoms of depression and interpersonal problems that contribute to symptoms of binge-eating disorder (BED) and overweight/obesity. Matched samples of overweight women with BED and overweight and normal weight women without BED completed the Adult Attachment Interview, a measure of depressive symptoms, and a measure of interpersonal problems. Greater symptoms of depression distinguished women with BED from the matched comparison samples...
April 18, 2017: Attachment & Human Development
https://www.readbyqxmd.com/read/28418216/adult-attachment-insecurity-is-positively-associated-with-medically-unexplained-chronic-pain
#4
L A McWilliams
BACKGROUND: Attachment insecurity (i.e. anxiety in relationships and/or discomfort in close relationships) is associated with self-reports of physical symptoms, medically unexplained symptoms and health conditions involving pain. Medically unexplained chronic pain (MUCP) may represent a particularly severe form of symptom reporting that is also characteristic of individuals with insecure attachment. This study investigated relationships between adult attachment style ratings and past-year MUCP in a sample of the general U...
April 18, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28416809/perisomatic-changes-in-h-channels-regulate-depressive-behaviors-following-chronic-unpredictable-stress
#5
C S Kim, D H Brager, D Johnston
Chronic stress can be a precipitating factor in the onset of depression. Lentiviral-mediated knockdown of HCN1 protein expression and reduction of functional Ih produce antidepressant behavior. However, whether h-channels are altered in an animal model of depression is not known. We found that perisomatic HCN1 protein expression and Ih-sensitive physiological measurements were significantly increased in dorsal but not in ventral CA1 region/neurons following chronic unpredictable stress (CUS), a widely accepted model for major depressive disorder...
April 18, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28413687/what-we-have-changed-our-minds-about-part-1-borderline-personality-disorder-as-a-limitation-of-resilience
#6
REVIEW
Peter Fonagy, Patrick Luyten, Elizabeth Allison, Chloe Campbell
This paper sets out a recent transition in our thinking in relation to psychopathology associated with personality disorder, in an approach that integrates our thinking about attachment, mentalizing (understanding ourselves and others in terms of intentional mental states) and epistemic trust (openness to the reception of social communication that is personally relevant and of generalizable significance) with recent findings on the structure of both adult and child psychopathology and resilience. In this paper - the first of two parts - we review evidence suggesting that a general psychopathology or p factor underlies vulnerability for psychopathology...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/28412517/challenges-around-access-to-and-cost-of-life-saving-medications-after-allogeneic-hematopoietic-cell-transplantation-for-medicare-patients
#7
Stephanie Farnia, Alex Ganetsky, Alicia Silver, Theresa Hwee, Jaime Preussler, Joan Griffin, Nandita Khera
Hematopoietic cell transplantation (HCT) is an expensive, medically complicated and potentially life-threatening therapy for multiple hematologic and non-hematologic disorders with a prolonged trajectory of recovery. Similar to financial issues in other cancer treatments, adverse financial consequences of HCT are emerging as an important issue, and may be associated with poor quality of life (QOL) and increased distress in HCT survivors. Prescription medicine coverage for HCT for Medicare and some Medicaid beneficiaries, especially in the long-term remains suboptimal due to inadequate payer formularies or prohibitive co-pays...
April 12, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28411577/perceived-parental-child-rearing-and-attachment-as-predictors-of-anxiety-and-depressive-disorder-symptoms-in-children-the-mediational-role-of-attachment
#8
Paloma Chorot, Rosa M Valiente, Ana M Magaz, Miguel A Santed, Bonifacio Sandin
The present study aimed to examine (a) the relative contribution of perceived parental child-rearing behaviors and attachment on anxiety and depressive symptoms, and (b) the role of attachment as a possible mediator of the association between parental rearing and anxiety and depression. A sample of 1002 children (aged 9-12 years) completed a booklet of self-report questionnaires measuring parental rearing behaviors, attachment towards peers, and DSM anxiety and depressive disorder symptoms. We found that parental aversiveness, parental neglect, and fearful/preoccupied attachment, each accounted for a significant amount of the variance in both anxiety and depressive symptoms...
April 7, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28409730/chronic-multisite-brain-recordings-from-a-totally-implantable-bidirectional-neural-interface-experience-in-5-patients-with-parkinson-s-disease
#9
Nicole C Swann, Coralie de Hemptinne, Svjetlana Miocinovic, Salman Qasim, Jill L Ostrem, Nicholas B Galifianakis, Marta San Luciano, Sarah S Wang, Nathan Ziman, Robin Taylor, Philip A Starr
OBJECTIVE Dysfunction of distributed neural networks underlies many brain disorders. The development of neuromodulation therapies depends on a better understanding of these networks. Invasive human brain recordings have a favorable temporal and spatial resolution for the analysis of network phenomena but have generally been limited to acute intraoperative recording or short-term recording through temporarily externalized leads. Here, the authors describe their initial experience with an investigational, first-generation, totally implantable, bidirectional neural interface that allows both continuous therapeutic stimulation and recording of field potentials at multiple sites in a neural network...
April 14, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28408961/the-usefulness-of-diagnostic-imaging-for-the-assessment-of-pain-symptoms-in-temporomandibular-disorders
#10
REVIEW
Shigeaki Suenaga, Kunihiro Nagayama, Taisuke Nagasawa, Hiroko Indo, Hideyuki J Majima
The causes of pain symptoms in the temporomandibular joint (TMJ) and masticatory muscle (MM) regions may not be determined by clinical examination alone. In this review, we document that pain symptoms of the TMJ and MM regions in patients with temporomandibular disorders (TMDs) are associated with computed tomography and magnetic resonance (MR) findings of internal derangement, joint effusion, osteoarthritis, and bone marrow edema. However, it is emphasized that these imaging findings must not be regarded as the unique and dominant factors in defining TMJ pain...
November 2016: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28405338/what-we-have-changed-our-minds-about-part-2-borderline-personality-disorder-epistemic-trust-and-the-developmental-significance-of-social-communication
#11
REVIEW
Peter Fonagy, Patrick Luyten, Elizabeth Allison, Chloe Campbell
In Part 1 of this paper, we discussed emerging evidence suggesting that a general psychopathology or 'p' factor underlying the various forms of psychopathology should be conceptualized in terms of the absence of resilience, that is, the absence of positive reappraisal mechanisms when faced with adversity. These impairments in the capacity for positive reappraisal seem to provide a comprehensive explanation for the association between the p factor and comorbidity, future caseness, and the 'hard-to-reach' character of many patients with severe personality pathology, most notably borderline personality disorder (BPD)...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/28402069/anorexia-nervosa-theory-and-treatment-where-are-we-35%C3%A2-years-on-from-hilde-bruch-s-foundation-lecture
#12
REVIEW
Janet Treasure, Valentina Cardi
Hilde Bruch's foundation lecture in 1982 is a milestone from which to survey current theory and treatment for anorexia nervosa. Bruch described problems in body perception, emotion processing and interpersonal relationships as core theoretical aspects of the illness and built her theory of psychopathology on these aspects, as well as on animal studies on attachment. She also noted that many psychological problems result as consequence of starvation. In the first part of this paper, we parse Bruch's clinical descriptions into elements of psychopathology (disturbances in body perception, attachment, emotion expression, perception and regulation, social comparison, interpersonal, and family and therapeutic relationships), in order to assemble and update the theoretical evidence for a model of the illness...
May 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/28401844/signs-of-reactive-attachment-disorder-and-disinhibited-social-engagement-disorder-at-age-12-years-effects-of-institutional-care-history-and-high-quality-foster-care
#13
Kathryn L Humphreys, Charles A Nelson, Nathan A Fox, Charles H Zeanah
Two disorders of attachment have been consistently identified in some young children following severe deprivation in early life: reactive attachment disorder and disinhibited social engagement disorder. However, less is known about whether signs of these disorders persist into adolescence. We examined signs of reactive attachment disorder and disinhibited social engagement disorder at age 12 years in 111 children who were abandoned at or shortly after birth and subsequently randomized to care as usual or to high-quality foster care, as well as in 50 comparison children who were never institutionalized...
May 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28398918/histological-features-of-methylene-blue-induced-phototoxicity-administered-in-the-context-of-parathyroid-surgery
#14
Ciara A Maguire, Anup Sharma, Lida Alarcon, Lorrette Ffolkes, Malgorzata Kurzepa, Lucy Ostlere, Venura Samarasinghe, Manuraj Singh
Methylene blue is a chromophore dye known for its photosensitizing properties. It is also administered intravenously as a tracer in parathyroid surgery to identify abnormal glands. We describe 2 cases of acute methylene blue-induced phototoxicity in patients who underwent parathyroidectomy. Both patients developed an acute vesiculopustular inflammatory rash on the anterior neck corresponding to the site exposed intraoperatively to overhanging surgical lights. One of the patients also developed a bulla on her finger at the site of attachment of the oxygen probe...
March 16, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28397403/the-neurobiology-of-social-deficits-in-female-patients-with-borderline-personality-disorder-the-importance-of-oxytocin
#15
Anne Cathrine Bomann, Martin Balslev Jørgensen, Sune Bo, Marianne Nielsen, Lene Bjerring Gede, Betina Elfving, Erik Simonsen
BACKGROUND: Social deficits and emotional dysregulation have been suggested as explanations for the relational difficulties experienced by patients with borderline personality disorder (BPD). The neuropeptide oxytocin (OXT) is a possible neurobiological underpinning of these adversities, and this study examines possible correlations between BPD symptomatology and serum OXT. METHODS: Thirty-eight female participants (BPD group n = 18, matched control group n = 20) with a mean age of 29...
April 11, 2017: Personality and Mental Health
https://www.readbyqxmd.com/read/28393369/why-we-need-to-know-the-structure-of-phosphorylated-chloroplast-light-harvesting-complex-ii
#16
John F Allen
In oxygenic photosynthesis there are two "light states" - adaptations of the photosynthetic apparatus to spectral composition that otherwise favours either Photosystem I or Photosystem II. In chloroplasts of green plants, the transition to light state 2 depends on phosphorylation of apoproteins of a membrane-intrinsic antenna, the chlorophyll-a/b-binding, light-harvesting complex II (LHC II), and on the resulting redistribution absorbed excitation energy from Photosystem II to Photosystem I. The transition to light state 1 reverses these events and requires a phospho-LHC II phosphatase...
April 9, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28392471/expression-of-mutant-disc1-in-purkinje-cells-increases-their-spontaneous-activity-and-impairs-cognitive-and-social-behaviors-in-mice
#17
Alexey V Shevelkin, Chantelle E Terrillion, Bagrat N Abazyan, Tymoteusz J Kajstura, Yan A Jouroukhin, Gay L Rudow, Juan C Troncoso, David J Linden, Mikhail V Pletnikov
In addition to motor function, the cerebellum has been implicated in cognitive and social behaviors. Various structural and functional abnormalities of Purkinje cells (PCs) have been observed in schizophrenia and autism. As PCs express the gene Disrupted-In-Schizophrenia-1 (DISC1), and DISC1 variants have been associated with neurodevelopmental disorders, we evaluated the role of DISC1 in cerebellar physiology and associated behaviors using a mouse model of inducible and selective expression of a dominant-negative, C-terminus truncated human DISC1 (mutant DISC1) in PCs...
April 6, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28392275/exploring-the-influence-of-indololactone-structure-on-selectivity-for-binding-to-the-c1-domains-of-pkc%C3%AE-pkc%C3%AE%C2%B5-and-rasgrp
#18
Eleonora Elhalem, Lucía Gandolfi Donadío, Xiaoling Zhou, Nancy E Lewin, Lia C Garcia, Christopher C Lai, James A Kelley, Megan L Peach, Peter M Blumberg, María J Comin
C1 domain-containing proteins, such as protein kinase C (PKC), have a central role in cellular signal transduction. Their involvement in many diseases, including cancer, cardiovascular disease, and immunological and neurological disorders has been extensively demonstrated and has prompted a search for small molecules to modulate their activity. By employing a diacylglycerol (DAG)-lactone template, we have been able to develop ultra potent analogs of diacylglycerol with nanomolar binding affinities approaching those of complex natural products such as phorbol esters and bryostatins...
March 10, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28382385/neighborhood-determinants-of-mood-and-anxiety-disorders-among-men-who-have-sex-with-men-in-new-york-city
#19
Magdalena Cerdá, Vijay Nandi, Victoria Frye, James E Egan, Andrew Rundle, James W Quinn, Daniel Sheehan, Donald R Hoover, Danielle C Ompad, Hong Van Tieu, Emily Greene, Beryl Koblin
PURPOSE: We examined the relationship between economic, physical, and social characteristics of neighborhoods, where men who have sex with men (MSM) lived and socialized, and symptom scores of depression and generalized anxiety disorder (GAD). METHODS: Participants came from a cross-sectional study of a population-based sample of New York City MSM recruited in 2010-2012 (n = 1126). Archival and survey-based data were obtained on neighborhoods, where the men lived and where they socialized most often...
April 5, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28380532/effects-of-a-simulated-wolf-encounter-on-brain-and-blood-biomarkers-of-stress-related-psychological-disorders-in-beef-cows-with-or-without-previous-exposure-to-wolves
#20
R F Cooke, L R Mehrkam, R S Marques, K D Lippolis, D W Bohnert
This experiment compared mRNA expression of brain-blood biomarkers associated with stress-related psychological disorders, including post-traumatic stress disorder (PTSD), in beef cows from wolf-naïve and wolf-experienced origins that were subjected to a simulated wolf encounter. Multiparous, non-pregnant, non-lactating Angus-crossbred cows from the Eastern Oregon Agricultural Research Center (Burns, OR; CON; = 10) and from a commercial operation near Council, ID (WLF; = 10) were used. To date, gray wolves are not present around Burns, OR, and thus CON were naïve to wolves...
March 2017: Journal of Animal Science
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