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https://www.readbyqxmd.com/read/28915775/wound-healing-and-anti-inflammatory-effects-of-topical-hyaluronic-acid-injection-in-surgical-site-infection-caused-by-staphylococcus-aureus
#1
Jin Hyung Park, Eon Ju Park, Hyung Suk Yi
Surgical-site infection (SSI) is a common postoperative complication, primarily caused by Staphylococcus aureus. S aureus produces hyaluronidase which degrades hyaluronic acid (HA). HA prevents bacterial proliferation and has anti-inflammatory effects to promote wound healing. We evaluated the effect of HA injection with systemic antibiotics for prevention and treatment of SSIs caused by S aureus. An open wound was created on the dorsum of 40 rats. The wound bed was sutured with S aureus inoculated thread. The test group was injected with HA (HA group), and the control group received a subcutaneous injection of normal saline (NS group)...
September 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28906088/bullous-cutaneous-larva-migrans-case-series-and-review-of-atypical-clinical-presentations
#2
Stefano Veraldi, Ermira Çuka, Paolo Pontini, Fabrizio Vaira
Hookworm-related cutaneous larva migrans (HRCLM) is caused by the penetration and migration in the epidermis of larvae of Ancylostoma braziliense and Ancylostoma caninum. It is characterized by slightly raised and erythematous tracks, located especially on the feet. These tracks may be single or multiple, serpiginous or linear, ramified and intertwined, accompanied by pruritus. Atypical clinical presentations of HRCLM are currently more frequent than in the past. We present six patients with bullous HRCLM and discuss the possible pathogenetic factors...
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28904556/medicinal-plants-for-the-treatment-of-local-tissue-damage-induced-by-snake-venoms-an-overview-from-traditional-use-to-pharmacological-evidence
#3
REVIEW
Juliana Félix-Silva, Arnóbio Antônio Silva-Junior, Silvana Maria Zucolotto, Matheus de Freitas Fernandes-Pedrosa
Snakebites are a serious problem in public health due to their high morbimortality. Most of snake venoms produce intense local tissue damage, which could lead to temporary or permanent disability in victims. The available specific treatment is the antivenom serum therapy, whose effectiveness is reduced against these effects. Thus, the search for complementary alternatives for snakebite treatment is relevant. There are several reports of the popular use of medicinal plants against snakebites worldwide. In recent years, many studies have been published giving pharmacological evidence of benefits of several vegetal species against local effects induced by a broad range of snake venoms, including inhibitory potential against hyaluronidase, phospholipase, proteolytic, hemorrhagic, myotoxic, and edematogenic activities...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28895415/hyaluronic-acid-hyaluronidase-as-biomarkers-for-bladder-cancer-a-diagnostic-meta-analysis
#4
Z Liang, Q Zhang, Ch Wang, F Shi, H Cao, Y Yu, M Zhang, X Liu
This study aimed to determine the value of HA/HAase for detecting bladder cancer on the basis of preceding statistical performance. PubMed, Springer Link, Web of Science and Cochrane Library were systematically searched to identify potentially relevant published articles by using the key words: "bladder cancer or bladder tumor or bladder carcinoma", "hyaluronic acid or hyaluronan", "hyaluronidase or HAase". The methodological quality of each study was assessed by QUADAS-2. According to the inclusive and exclusive criteria, 8 articles were identified and methodologically analyzed by STATA 12...
September 12, 2017: Neoplasma
https://www.readbyqxmd.com/read/28894123/mutations-in-the-prostate-specific-antigen-psa-klk3-correlate-with-male-infertility
#5
Nishi Gupta, Digumarthi V S Sudhakar, Pravin Kumar Gangwar, Satya Narayan Sankhwar, Nalini J Gupta, Baidyanath Chakraborty, Kumarasamy Thangaraj, Gopal Gupta, Singh Rajender
Prostate specific antigen (PSA/KLK3) is known to be the chief executor of the fragmentation of semenogelins, dissolution of semen coagulum, thereby releasing sperm for active motility. Recent research has found that semenogelins also play significant roles in sperm fertility by affecting hyaluronidase activity, capacitation and motility, thereby making PSA important for sperm fertility beyond simple semen liquefaction. PSA level in semen has been shown to correlate with sperm motility, suggesting that PSA level/activity can affect fertility...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28888002/construction-of-multifunctional-porous-silica-nanocarriers-for-ph-enzyme-responsive-drug-release
#6
Li Qiu, Weirui Zhang, Shuyun Wang, Xu Zhang, Yanbao Zhao, Liuqin Cao, Lei Sun
pH/enzyme-responsive nanocarriers based on porous silica (pSiO2) nanospheres (NSs) were developed for controlled release of drug. The pSiO2 NSs present uniform spheres and have an average diameter of 100nm. The pSiO2 NSs with high specific surface area (835m(2)·g(-1)) and the pore volume (1.24cm(3)·g(-1)) are suitable for drug loading and the loading capacity reaches to 29% for amoxicillin (AMX) model drug. In this system, protocatechuic acid (PCA) and L-glutamic acid (Glu) as linkers were grafting onto the surface of pSiO2 NSs to conjugate the capping lids...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28887453/hyaluronic-acid-based-extracellular-matrix-regulates-surface-expression-of-glun2b-containing-nmda-receptors
#7
Barbara Schweitzer, Jeet Singh, Anna Fejtova, Laurent Groc, Martin Heine, Renato Frischknecht
Cortical areas of the juvenile rodent brain display a high degree of structural and functional plasticity, which disappears later in development. Coincident with the decline of plasticity 1) the hyaluronic acid-based extracellular matrix (ECM) of the brain, which stabilizes synapses and neuronal circuit is formed and 2) N-methyl-D-aspartate subtype of ionotropic glutamate receptors (NMDARs) implied in synaptic plasticity switch from mainly GluN2B to GluN2A subunit-containing receptors. Here we tested the hypothesis that ECM influences the NMDAR subunit composition in dissociated neuronal cultures...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877147/restoration-of-visual-loss-with-retrobulbar-hyaluronidase-injection-after-hyaluronic-acid-filler
#8
Cameron Chesnut
No abstract text is available yet for this article.
September 1, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28875930/light-reintroduction-after-dark-exposure-reactivates-plasticity-in-adults-via-perisynaptic-activation-of-mmp-9
#9
Sachiko Murase, Crystal Lantz, Elizabeth Quinlan
The sensitivity of ocular dominance to regulation by monocular deprivation is the canonical model of plasticity confined to a critical period. However, we have previously shown that visual deprivation through dark exposure (DE) reactivates critical period plasticity in adults. Previous work assumed that the elimination of visual input was sufficient to enhance plasticity in the adult mouse visual cortex. In contrast, here we show that light reintroduction (LRx) after DE is responsible for the reactivation of plasticity...
September 6, 2017: ELife
https://www.readbyqxmd.com/read/28871852/recombinant-human-hyaluronidase-facilitated-subcutaneous-immunoglobulin-infusion-in-primary-immunodeficiency-diseases
#10
Richard L Wasserman
Most primary immunodeficiency diseases (PIDDs) resulting in antibody deficiency require intravenous or subcutaneous immunoglobulin G (SCIG) replacement therapy. The flow and distribution of SCIG to the vasculature is impeded by the glycosaminoglycan hyaluronan in the extracellular matrix, which limits the infusion rate and volume per site, necessitating frequent infusions and multiple infusion sites. Hyaluronidase depolymerizes hyaluronan and is a spreading factor for injectable biologics. Recombinant human hyaluronidase (rHuPH20) increases SCIG absorption and dispersion...
September 5, 2017: Immunotherapy
https://www.readbyqxmd.com/read/28871669/facilitated-subcutaneous-immunoglobulin-fscig-in-autoimmune-cytopenias-associated-with-common-variable-immunodeficiency
#11
Veronica Pedini, Isabella Savore, Giovanna Maria Danieli
BACKGROUND: Common variable immunodeficiency (CVID) is the most common symptomatic primary immune deficiency of adulthood. Besides recurrent infections, autoimmune disorders-mainly cytopenias-affect 30% of patients with CVID. OBJECTIVES: To describe the efficacy and safety of facilitated subcutaneous immunoglobulin (fSCIg), which is a combination of 10% [human] SCIg with recombinant human hyaluronidase for the treatment of CVID-linked cytopenias. METHODS: We describe four women (mean age 54 years) with CVID associated with idiopathic thrombocytopenic purpura (ITP) (n=3) and autoimmune hemolytic anemia (AIHA) (n=1)...
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28867161/hyaluronidase-injection-in-the-vocal-folds-for-vocal-hemorrhage-reinke-edema-and-hyaluronic-acid-overinjection-a-novel-application-in-the-larynx
#12
Peak Woo
Hyaluronidase (HAase) injection into the vocal folds is an off-label use of an enzyme for liquefaction of hyaluronic acid (HA). HAase injection was performed in 14 cases in 13 patients. Office and operative injections of HAase were performed. The indications were five cases of overinjection of HA, six cases of Reinke edema and polypoid corditis, and three cases of acute vocal hemorrhage with early fusiform polyp formation. All the patients tolerated the HAase without complications. Significant voice improvements were noted between pre- and postinjection procedures as evaluated by a self-rating of voice by the Voice Handicap Index-10...
August 31, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28860834/the-24-hour-skin-hydration-and-barrier-function-effects-of-a-hyaluronic-1-glycerin-5-and-centella-asiatica-stem-cells-extract-moisturizing-fluid-an-intra-subject-randomized-assessor-blinded-study
#13
Massimo Milani, Adele Sparavigna
INTRODUCTION: Moisturizing products are commonly used to improve hydration in skin dryness conditions. However, some topical hydrating products could have negative effects on skin barrier function. In addition, hydrating effects of moisturizers are not commonly evaluated up to 24 hours after a single application. Hyaluronic acid (HA) and glycerin are very well-known substances able to improve skin hydration. Centella asiatica extract (CAE) could exert lenitive, anti-inflammatory and reepithelialization actions...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28859900/inclusion-complex-from-cyclodextrin-grafted-hyaluronic-acid-and-pseudo-protein-as-biodegradable-nano-delivery-vehicle-for-gambogic-acid
#14
Ying Ji, Shuo Shan, Mingyu He, Chih-Chang Chu
β-Cyclodextrin can form inclusion complex with a series of guest molecules including phenyl moieties, and has gained considerable popularity in the study of supramolecular nanostructure. In this study, a biodegradable nanocomplex (HA(CD)-4Phe4 nanocomplex) was developed from β-cyclodextrin grafted hyaluronic acid (HA) and phenylalanine based poly(ester amide). The phenylalanine based poly(ester amide) is a biodegradable pseudo protein which provides the encapsulation capacity for gambogic acid (GA), a naturally-derived chemotherapeutic which has been effectively employed to treat multidrug resistant tumor...
August 30, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28858381/-microcystic-pattern-should-be-recognized-as-part-of-the-morphologic-spectrum-of-solid-pseudopapillary-neoplasm-of-the-pancreas
#15
Atsushi Abe, Yoshihiro Ohishi, Tetsuyuki Miyazaki, Keigo Ozono, Naoki Mochidome, Kiyoshi Saeki, Masafumi Nakamura, Yoshinao Oda
AIM: Solid pseudopapillary neoplasm (SPN) is an uncommon pancreatic tumor characterized by solid and pseudopapillary growth patterns. We have observed SPNs can show a microcystic pattern (microcystic SPN), which has been poorly described and may be confused with microcystic neoplasms. We conducted the present study to clarify the clinicopathological and immunohistochemical features of microcystic SPNs. METHOD: We examined a consecutive series of 44 SPNs and 10 SCAs, and we classified them into 13 microcystic SPNs (29...
August 31, 2017: Histopathology
https://www.readbyqxmd.com/read/28858172/hyaluronidase-understanding-its-properties-and-clinical-application-for-cosmetic-injection-adverse-events
#16
(no author information available yet)
No abstract text is available yet for this article.
July 2017: Plastic Surgical Nursing
https://www.readbyqxmd.com/read/28858168/hyaluronidase-understanding-its-properties-and-clinical-application-for-cosmetic-injection-adverse-events
#17
Jeanine Harrison, Oriol Rhodes
The recent global consensus on the management of cosmetic aesthetic injectable complications from hyaluronic acid (HA) has increased the focus on the use of hyaluronidase more than ever before (M. Signorini et al., 2016). A comprehensive knowledge of facial anatomy, including structural positioning of facial arteries and veins, and an extensive knowledge of HA products available for injection procedures, combined with best practice protocols, will assist to prevent adverse events. Despite the growing number of patients using cosmetic fillers for facial restoration, the incidents incidence of adverse events remains low...
July 2017: Plastic Surgical Nursing
https://www.readbyqxmd.com/read/28839403/evaluation-of-oral-pentoxifylline-in-the-management-of-oral-submucous-fibrosis-an-ultrasonographic-study
#18
Jayachandran Sadaksharam, Sureshkumar Mahalingam
AIM AND OBJECTIVE: To evaluate the therapeutic efficacy of oral pentoxifylline in the treatment of oral submucous fibrosis (OSMF) patients by assessing the clinical symptoms such as burning sensation, mouth opening, and submucosal layer thickness and echogenicity using ultrasonography, both pre- and post-operatively. MATERIALS AND METHODS: Thirty study subjects were included in the study and divided into two groups in single-blind randomized manner, oral pentoxifylline and dexamethasone group...
April 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/28837381/dermal-filler-associated-malar-edema-treatment-of-a-persistent-adverse-effect
#19
Shawn M Iverson, Rakesh M Patel
A 72-year-old Caucasian female presented for evaluation of bilateral lower eyelid "fluid filled" bags that had been present and slowly worsening for 7 years. She reported a history of lower eyelid blepharoplasty in her 40s, as well as hyaluronic acid tear trough fillers 8 years prior to presentation. Her malar edema completely resolved following injection of hyaluronidase. To our knowledge, this is the longest reported interval for presentation and treatment of hyaluronic acid associated malar edema.
August 24, 2017: Orbit
https://www.readbyqxmd.com/read/28826558/elucidating-mechanisms-of-bladder-repair-after-hyaluronan-instillation-in-ketamine-induced-ulcerative-cystitis-in-animal-model
#20
Yi-Lun Lee, Kun-Ling Lin, Shu-Mien Chuang, Yung-Chin Lee, Mei-Chin Lu, Bin-Nan Wu, Wen-Jeng Wu, Shyng-Shiou F Yuan, Wan-Ting Ho, Yung-Shun Juan
Ketamine-induced ulcerative cystitis (KIC) initially damaged the bladder mucosa and induced contracted bladder thereafter. Hyaluronan (hyaluronic acid; HA) instillation to the bladder has been used to treat KIC. The present study investigated bladder injury by urothelial defect and HA degeneration and bladder repair by urothelium proliferation and differentiation. This work was based on the hypothesis that HA treatment altered the bladder urothelial layer and the expression of hyaluronan-metabolizing enzymes and/or HA receptors in KIC...
September 2017: American Journal of Pathology
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