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developmental topographical disorientation

Giuseppe Iaria, Ford Burles
Developmental topographical disorientation (DTD) refers to the lifelong inability to orient in extremely familiar surroundings despite the absence of any acquired brain damage or neurological disorder. Here, we describe the findings of this newly discovered condition, and highlight how this phenomenon provides novel insights into the mechanisms underlying human spatial navigation.
October 2016: Trends in Cognitive Sciences
Jeffrey C Corrow, Sherryse L Corrow, Edison Lee, Raika Pancaroglu, Ford Burles, Brad Duchaine, Giuseppe Iaria, Jason J S Barton
Previous studies report that acquired prosopagnosia is frequently associated with topographic disorientation. Whether this is associated with a specific anatomic subtype of prosopagnosia, how frequently it is seen with the developmental variant, and what specific topographic function is impaired to account for this problem are not known. We studied ten subjects with acquired prosopagnosia from either occipitotemporal or anterior temporal (AT) lesions and seven with developmental prosopagnosia. Subjects were given a battery of topographic tests, including house and scene recognition, the road map test, a test of cognitive map formation, and a standardized self-report questionnaire...
March 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Jiye G Kim, Elissa M Aminoff, Sabine Kastner, Marlene Behrmann
UNLABELLED: Developmental topographic disorientation (DTD) is a life-long condition in which affected individuals are severely impaired in navigating around their environment. Individuals with DTD have no apparent structural brain damage on conventional imaging and the neural mechanisms underlying DTD are currently unknown. Using functional and diffusion tensor imaging, we present a comprehensive neuroimaging study of an individual, J.N., with well defined DTD. J.N. has intact scene-selective responses in the parahippocampal place area (PPA), transverse occipital sulcus, and retrosplenial cortex (RSC), key regions associated with scene perception and navigation...
September 16, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Federico Nemmi, Filippo Bianchini, Federica Piras, Patrice Péran, Liana Palermo, Laura Piccardi, Umberto Sabatini, Cecilia Guariglia
Developmental topographical disorientation (DTD) causes impaired spatial orientation and navigation from early childhood with no evidence of cerebral damage. Using fMRI and a landmark sequencing task, we investigated the hypothesis that Dr Wai's abnormal cerebral activation pattern was related to his peculiar behavioral profile. Although Dr Wai was able to correctly perform landmark sequencing, he showed a lack of activity in regions activated in all control subjects and activity in areas that were not activated in any control subject...
2015: Neurocase
Jason J S Barton
PURPOSE OF REVIEW: This article reviews the various types of visual dysfunction that can result from lesions of the cerebral regions beyond the striate cortex. RECENT FINDINGS: Patients with dyschromatopsia can exhibit problems with color constancy. The apperceptive form of prosopagnosia is associated with damage to posterior occipital and fusiform gyri, and an associative/amnestic form is linked to damage to more anterior temporal regions. Pure alexia can be accompanied by a surface dysgraphia...
August 2014: Continuum: Lifelong Learning in Neurology
Giuseppe Iaria, Aiden E G F Arnold, Ford Burles, Irene Liu, Edward Slone, Sarah Barclay, Torben N Bech-Hansen, Richard M Levy
Developmental topographical disorientation (DTD) is a newly discovered cognitive disorder in which individuals experience a lifelong history of getting lost in both novel and familiar surroundings. Recent studies have shown that such a selective orientation defect relies primarily on the inability of the individuals to form cognitive maps, i.e., mental representations of the surrounding that allow individuals to get anywhere from any location in the environment, although other orientation skills are additionally affected...
November 2014: Hippocampus
Liana Palermo, Laura Piccardi, Filippo Bianchini, Federico Nemmi, Vincenzo Giorgio, Chiara Incoccia, Umberto Sabatini, Cecilia Guariglia
Developmental topographical disorientation (DTD) is the presence of navigational deficits in the context of normal intellectual ability and in the absence of any perinatal, neurological, or psychiatric disorder. As only three cases of DTD have been fully described thus far, we are still unable to draw definitive conclusions about its nature and relationship with other visuospatial competencies, such as mental rotation. The case of Mr. L.A., a 38-year-old man with no history of neurological or psychiatric disorders, sheds some light on these open questions...
2014: Journal of Clinical and Experimental Neuropsychology
Liana Palermo, Francesca Foti, Fabio Ferlazzo, Cecilia Guariglia, Laura Petrosini
OBJECTIVE: Developmental Topographical Disorientation (DTD) is a selective difficulty in way-finding showed by individuals with normal intellectual ability. We aimed to clarify whether getting lost even in familiar contexts could be because of a variety of developmental deficits that may affect the acquisition of one or more navigational competencies. METHOD: Two DTD individuals were submitted to neuropsychological assessment and MRI exam, to verify the absence of further cognitive deficits and brain abnormalities; navigational and visuospatial tasks, and Radial Arm Maze (RAM) paradigms to assess spatial competencies; and switching paradigms to assess backward inhibition processes in spatial- and no-spatial contexts...
January 2014: Neuropsychology
Filippo Bianchini, Liana Palermo, Laura Piccardi, Chiara Incoccia, Federico Nemmi, Umberto Sabatini, Cecilia Guariglia
Recently, developmental topographical disorientation (DTD) was described (Bianchini et al., 2010, J Clin Exp Neuropsychol, 20, 807-27; Iaria & Barton, 2010, Exp Brain Res, 206, 189-96; Iaria, Bogod, Fox, & Barton, 2009, Neuropsychologia, 47, 30-40) as a navigational deficit in the absence of neurological or psychiatric disorders. Here, we reported the case of a healthy subject who presented this disorder. Dr. WAI was a 29-year-old right-handed man with normal development and no clinical history of neurological or psychiatric diseases who was affected by a very pervasive topographical orientation and navigational disorder...
March 2014: Journal of Neuropsychology
Jason J S Barton
PURPOSE OF REVIEW: Both monkey and human neuroimaging studies show that visual processing beyond the striate cortex involves a highly complex network of regions with modular functions. Lesions within this network lead to specific clinical syndromes. In this review we discuss studies on blindsight, which is the ability of remaining regions to support vision in the absence of striate cortex or visual awareness, recent work on 'ventral stream' syndromes such as object agnosia, alexia, prosopagnosia, and topographagnosia, which follow damage to medial occipitotemporal structures, and simultanagnosia, the classic 'dorsal stream' deficit related to bilateral occipitoparietal lesions...
February 2011: Current Opinion in Neurology
Giuseppe Iaria, Jason J S Barton
A variety of lesions in different cerebral regions may affect the human ability to orient in the environment, resulting in 'topographical disorientation'. In a recent study, we documented the first case of Developmental Topographical Disorientation (DTD), in a person with a life-long inability to orient despite otherwise well-preserved cognitive functions, and in the absence of a cerebral injury/malformation or other neurological condition. This selective topographical disorientation was due to her inability to form a 'cognitive map', a mental representation of the environment, which in turn impaired her ability to orient in both familiar and unfamiliar surroundings...
October 2010: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
F Bianchini, C Incoccia, L Palermo, L Piccardi, L Zompanti, U Sabatini, Patrice Peran, C Guariglia
We present the case of F.G., a healthy, normally developed 22-year-old male subject affected by a pervasive disorder in environmental orientation and navigation who presents no history of neurological or psychiatric disease. A neuro-radiological examination showed no evidence of anatomical or structural alterations to the brain. We submitted the subject for a comprehensive neuropsychological assessment of the different cognitive processes involved in topographical orientation to evaluate his ability to navigate the spatial environment...
May 2010: Neuropsychologia
Giuseppe Iaria, Nicholas Bogod, Christopher J Fox, Jason J S Barton
Topographical disorientation is the inability to orient within the environment, usually acquired from lesions to different cerebral regions participating in the attentional, perceptual or memory functions involved during navigation. We present the first case of a patient with topographical disorientation in the absence of any structural lesion and with intact sensory and intellectual function. Experimental tests in both real and virtual environments revealed a selective impairment in forming a mental representation of the environment, namely a cognitive map...
January 2009: Neuropsychologia
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