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https://www.readbyqxmd.com/read/26934351/-the-effect-of-radiotherapy-on-the-antitumor-immune-response-possibilities-to-combine-radiotherapy-with-immunotherapy
#1
Katalin Lumniczky, Géza Sáfrány
The past three decades of immunology research led to a drastic increase in the knowledge of antitumor immune response mechanisms and in parallel to a rapid development in various antitumor immune therapy strategies. This will most probably result in the implementation of immunotherapeutic protocols within the standard anticancer regimens in a very near future. Though, it is obvious that combination of immunotherapy with traditional anticancer treatment modalities will only be legitimate if the combination has at least an additive, or perhaps a synergistic effect...
March 2, 2016: Magyar Onkologia
https://www.readbyqxmd.com/read/26897718/radioimmunotherapy-for-treatment-of-acute-leukemia
#2
REVIEW
Caroline Bodet-Milin, Françoise Kraeber-Bodéré, Thomas Eugène, François Guérard, Joëlle Gaschet, Clément Bailly, Marie Mougin, Mickaël Bourgeois, Alain Faivre-Chauvet, Michel Chérel, Patrice Chevallier
Acute leukemias are characterized by accumulation of immature cells (blasts) and reduced production of healthy hematopoietic elements. According to the lineage origin, two major leukemias can be distinguished: acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). Although the survival rate for pediatric ALL is close to 90%, half of the young adults with AML or ALL and approximately 90% of older patients with AML or ALL still die of their disease, raising the need for innovative therapeutic approaches...
March 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/26128919/tu-cd-303-04-radiation-induced-long-distance-tumor-cell-migration-into-and-out-of-the-radiation-field-and-its-clinical-implication
#3
E Graves
UNLABELLED: Recent advances in cancer research have shed new light on the complex processes of how therapeutic radiation initiates changes at cellular, tissue, and system levels that may lead to clinical effects. These new advances may transform the way we use radiation to combat certain types of cancers. For the past two decades many technological advancements in radiation therapy have been largely based on the hypothesis that direct radiation-induced DNA double strand breaks cause cell death and thus tumor control and normal tissue damage...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26128915/tu-cd-303-02-beyond-radiation-induced-double-strand-breaks-a-new-horizon-for-radiation-therapy-research
#4
S Chang
UNLABELLED: Recent advances in cancer research have shed new light on the complex processes of how therapeutic radiation initiates changes at cellular, tissue, and system levels that may lead to clinical effects. These new advances may transform the way we use radiation to combat certain types of cancers. For the past two decades many technological advancements in radiation therapy have been largely based on the hypothesis that direct radiation-induced DNA double strand breaks cause cell death and thus tumor control and normal tissue damage...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26128914/tu-cd-303-05-unveiling-tumor-heterogeneity-by-molecular-imaging
#5
R Jeraj
UNLABELLED: Recent advances in cancer research have shed new light on the complex processes of how therapeutic radiation initiates changes at cellular, tissue, and system levels that may lead to clinical effects. These new advances may transform the way we use radiation to combat certain types of cancers. For the past two decades many technological advancements in radiation therapy have been largely based on the hypothesis that direct radiation-induced DNA double strand breaks cause cell death and thus tumor control and normal tissue damage...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26128913/tu-cd-303-03-localized-radiation-can-induce-systemic-anti-cancer-immune-and-non-immune-responses-and-how-we-might-utilize-it
#6
M Ahmed
UNLABELLED: Recent advances in cancer research have shed new light on the complex processes of how therapeutic radiation initiates changes at cellular, tissue, and system levels that may lead to clinical effects. These new advances may transform the way we use radiation to combat certain types of cancers. For the past two decades many technological advancements in radiation therapy have been largely based on the hypothesis that direct radiation-induced DNA double strand breaks cause cell death and thus tumor control and normal tissue damage...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26127793/su-e-t-124-anthropomorphic-phantoms-for-confirmation-of-linear-accelerator-based-small-animal-irradiation
#7
J Perks, S Lucero, S Benedict
PURPOSE: To document the support of radiobiological small animal research by a modern radiation oncology facility. This study confirms that a standard, human use linear accelerator can cover the range of experiments called for by researchers performing animal irradiation. A number of representative, anthropomorphic murine phantoms were made. The phantoms confirmed the small field photon and electron beams dosimetry validated the use of the linear accelerator for rodents. METHODS: Laser scanning a model, CAD design and 3D printing produced the phantoms...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26117368/degro-practical-guidelines-for-radiotherapy-of-non-malignant-disorders-part-i-physical-principles-radiobiological-mechanisms-and-radiogenic-risk
#8
Berthold Reichl, Andreas Block, Ulrich Schäfer, Christoph Bert, Reinhold Müller, Horst Jung, Franz Rödel
PURPOSE: Synopsis of the introductory paragraph of the DEGRO consensus S2e-guideline recommendations for the radiotherapy of benign disorders, including physical principles, radiobiological mechanisms, and radiogenic risk. MATERIALS AND METHODS: This work is based on the S2e-guideline recommendations published November 14, 2013. The basic principles of radiation physics and treatment delivery, evaluation of putative underlying radiobiological mechanisms, and the assessment of genetic and cancer risk following low-dose irradiation will be presented...
September 2015: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/24766384/ascorbic-acid-its-role-in-immune-system-and-chronic-inflammation-diseases
#9
REVIEW
Angela Sorice, Eliana Guerriero, Francesca Capone, Giovanni Colonna, Giuseppe Castello, Susan Costantini
Ascorbic acid (AA), also known as vitamin C, was initially identified as the factor preventing the scurvy disease, and became very popular for its antioxidant properties. It is an important co-substrate of a large class of enzymes, and regulates gene expression by interacting with important transcription factors. AA is important in all stressful conditions that are linked to inflammatory processes and involve immunity. It has been known for decades that the persistence of an inflammatory stimulus is responsible for the onset of many diseases...
May 2014: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/24300415/functional-interrogation-of-adult-hypothalamic-neurogenesis-with-focal-radiological-inhibition
#10
Daniel A Lee, Juan Salvatierra, Esteban Velarde, John Wong, Eric C Ford, Seth Blackshaw
The functional characterization of adult-born neurons remains a significant challenge. Approaches to inhibit adult neurogenesis via invasive viral delivery or transgenic animals have potential confounds that make interpretation of results from these studies difficult. New radiological tools are emerging, however, that allow one to noninvasively investigate the function of select groups of adult-born neurons through accurate and precise anatomical targeting in small animals. Focal ionizing radiation inhibits the birth and differentiation of new neurons, and allows targeting of specific neural progenitor regions...
2013: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/23828380/optimization-of-physico-chemical-properties-of-carbon-enterosorbents-and-evaluation-of-their-sorption-activity-for-use-in-the-treatment-of-paraneoplastic-syndrome-and-other-endogenous-intoxications-in-cancer-patients
#11
V V Sarnatskaya, A S Sidorenko, D A Klymchuk, I M Khohulya, L A Yushko, V N Maslenniy, V G Nikolaev
AIM: Development of carbon enterosorbents with optimal physical-chemical properties and high adsorptive capacity for their usage in the treatment of paraneoplastic syndrome and other endogenous intoxication in cancer patients. METHODS: physical-chemical and biochemical methods of investigation. RESULTS: In the work it has been shown that performance of additional steam activation on pilot plant developed in R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology NAS of Ukraine, allows produce highly active granulated and fibrous carbon enterosorbents which possess well developed porous surface providing potent sorption potential toward compounds of hydrophilic and hydrophobic nature...
June 2013: Experimental Oncology
https://www.readbyqxmd.com/read/20334512/links-between-innate-immunity-and-normal-tissue-radiobiology
#12
REVIEW
Dörthe Schaue, William H McBride
The body senses "danger" from "damaged self" molecules through members of the same receptor superfamily it uses for microbial "non-self", triggering canonical signaling pathways that lead to the generation of acute inflammatory responses. For this reason, the biology of normal tissue responses to moderate and clinically relevant doses of radiation is inextricably connected to innate immunity. The complex sequence of inflammatory events that ensues causes further cell and tissue damage to eliminate potential invaders but also leads to cytoprotective responses that limit the spread of damage and to wound healing through tissue regeneration or replacement...
April 2010: Radiation Research
https://www.readbyqxmd.com/read/19799367/-an-experimental-model-of-studynig-radiation-oppression-of-antitumor-resistance
#13
A A Ivanov, T A Nasonova, N G Darenskaia, O A Dobrynina, G I Sidorovich
In experiences on mice (CBA x C57Bl) F1 the experimental model for studying action of radiation on antineoplastic resistance is developed. Adequate ways of statistical processing of the received data testifying to amplification of tumoral growth in the irradiated organism are offered. The use of model of the solid form of the tumor developing after introduction in a shin of a hinder leg of the mouse of 1000 cells ascetic carcinoma of Ehrlich in a combination to radiating depression of antineoplastic resistance at animals after an irradiation on installation IGUR (137Cs) in a doze 6 Gy is proved...
July 2009: Radiatsionnaia Biologiia, Radioecologiia
https://www.readbyqxmd.com/read/19330149/radiobiological-basis-for-cancer-therapy-by-total-or-half-body-irradiation
#14
Kiyohiko Sakamoto
The tumor control effects by total-body irradiation (TBI) or half-body irradiation (HBI) on tumor-bearing mice and human cancer were investigated. In fundamental studies using a murine experimental system, mice that received 10 or 15 cGy of TBI showed a high value of TD(50) (number of tumor cells required for successful transplantation to a half group of injected sites) compared with nonirradiated control mice. The combination of low doses of TBI and local irradiation on tumor-bearing mice demonstrated enhanced tumor cell killing compared with only local irradiation, but this tumor-cell killing effect was not observed following 10 or 15 cGy of TBI alone...
October 2004: Nonlinearity in Biology, Toxicology, Medicine
https://www.readbyqxmd.com/read/19249647/cancer-stem-cells-and-tumor-response-to-therapy-current-problems-and-future-prospects
#15
REVIEW
Luka Milas, Walter N Hittelman
The presence of a subpopulation of cells within tumors, so-called cancer stemlike cells, that is uniquely capable of reestablishing the tumor during and after definitive radio(chemo)therapy and must be effectively controlled for a long-term cure is being increasingly appreciated. The existence and physiology of a rare cancer cell population, termed cancer cell clonogens, with similar properties has been extensively described in the radiobiology literature for several decades based on studies using tumor cells transplanted into syngeneic or immunodeficient animals...
April 2009: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/18689253/-the-analytical-review-of-the-schemes-of-the-acute-radiation-disease-treatment-used-in-experiment-and-in-clinic
#16
REVIEW
A E Baranov, L M Rozhdestvenskiĭ
The analysis of the original sources showed that there are some differences in approaches to radiation injuries treatment used mainly by Russian and foreign researches in their experiments. In Russian radiobiology the main way was the single usage of high molecular substances of different chemical structure and of natural origin soon after radiation exposure. These substances were designated then as cytokine inductors. Foreign researchers investigated in the beginning analogous substances too, but then--recombinant cytokines exclusively...
May 2008: Radiatsionnaia Biologiia, Radioecologiia
https://www.readbyqxmd.com/read/18648556/radiobiological-basis-of-low-dose-irradiation-in-prevention-and-therapy-of-cancer
#17
Myron Pollycove
Antimutagenic DNA damage-control is the central component of the homeostatic control essential for survival. Over eons of time, this complex DNA damage-control system evolved to control the vast number of DNA alterations produced by reactive oxygen species (ROS), generated principally by leakage of free radicals from mitochondrial metabolism of oxygen. Aging, mortality and cancer mortality are generally accepted to be associated with stem cell accumulation of permanent alterations of DNA, i.e., the accumulation of mutations...
2007: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/17487675/radiobiological-mechanisms-in-inflammatory-diseases-of-low-dose-radiation-therapy
#18
REVIEW
F Rödel, L Keilholz, M Herrmann, R Sauer, G Hildebrandt
PURPOSE: Whereas X-irradiation with high doses is established to exert pro-inflammatory effects, low-dose radiotherapy (LD-RT) with single fractions below 1.0 Gy and a total dose below 12 Gy is clinically well known to exert anti-inflammatory and analgesic effects on several inflammatory diseases and painful degenerative disorders. Experimental studies to confirm the effectiveness, the empirical dose and fractionation schemes, and the underlying radiobiological mechanisms are still fragmentary...
June 2007: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/15175867/-antitumoral-action-of-interferons-and-interleukins-in-combination-with-radiotherapy-part-ii-radiobiological-and-immunologic-strategies
#19
REVIEW
Carsten Herskind, Katharina Fleckenstein, Jens Lohr, Chuan-Yuan Li, Frederik Wenz, Frank Lohr
BACKGROUND: Combined tumor treatment with cytokines, e. g., interferons (IFN), and radiotherapy was initially of phenomenological nature but has increasingly been based on a radiobiological rationale. However, an improved understanding of the complex interactions of the cytokine network within the immune system warrants the rationale for such studies to be reviewed. METHODS: Based on published clinical studies, the results of treatment with interferons in combination with radiotherapy are reviewed...
June 2004: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/14305136/-possibilities-of-influencing-sensitizing-and-desensitizing-agents-in-radiochemistry-and-radiobiology-v-on-the-cancerogenicity-of-cholesterol-cholesterol-5-hydrogen-peroxide-and-cholesterol-7-hydrogen-peroxide
#20
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