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https://www.readbyqxmd.com/read/27915335/network-meta-analysis-of-pharmacological-agents-for-osteoporosis-treatment-and-fracture-prevention
#1
Xu-Cheng Yang, Zhen-Han Deng, Ting Wen, Wei Luo, Wen-Feng Xiao, Rui-Bo Zhao, Yu-Sheng Li
BACKGROUND AND OBJECTIVE: Osteoporosis afflicts a large number of populations in the world and is featured by systemic impairment of bone mass and strength which may further trigger an increase in the risk of fragile fractures. This network meta-analysis (NMA) is designed to distinguish therapies more preferable than others with respect to efficacy and safety. METHODS: We searched the medical literature for relevant studies systematically. Both direct and indirect evidence were synthesized to compare the efficacy, described by odds ratios (OR) and 95% credible intervals (CrI)...
December 5, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27910799/validation-of-the-danish-version-of-the-quick-disabilities-of-arm-shoulder-and-hand-questionnaire
#2
Jesper Ougaard Schønnemann, Jens Eggers
INTRODUCTION: The Quick-Disabilities of Arm, Shoulder and Hand (QuickDASH) questionnaire is an 11-item region-specific questionnaire used to measure the effect of clinical treatment of disorders and injuries to the upper extremity. During its original development, it was shown that the QuickDASH is a valid and reliable outcome measure. The purpose of this study was to validate the Danish version of the QuickDASH in patients with wrist fractures, using the Nottingham Health Profile (NHP) as an evaluation tool...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27890199/-what-is-the-role-of-primary-or-secondary-hemiarthroplasty-for-distal-radius-fractures-in-independent-elderly-patients
#3
G Herzberg, M Burnier
The authors report their experience with wrist hemiarthroplasty for acute irreparable distal radius fractures in independent elderly patients (12 women, mean age 76years) and following failed initial treatment in the same population (5 women, mean age 75years). The first 11 cases have a mean follow-up of 30months. No complications requiring implant removal were reported. At follow-up, the mean VAS for pain was 1/10, the mean flexion-extension arc was 60°, the Lyon Wrist score was 73 % and the PRWE (Patient-Related Wrist Evaluation) was 22 points...
December 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27886828/wrist-arthroscopy-for-athletic-injuries
#4
REVIEW
Rick Tosti, Eon Shin
Management of hand and wrist injuries for athletes often places emphasis on an expeditious return to sport. Arthroscopic techniques have the advantage of directly visualizing joint derangements and correcting them via a minimally invasive approach. This article discusses the evaluation and management of common wrist injuries treated with arthroscopy in athletes, including scapholunate and lunotriquetral injury, triangular fibrocartilage complex tears, hamatolunate impingement, and arthroscopic-assisted reduction of wrist fractures...
February 2017: Hand Clinics
https://www.readbyqxmd.com/read/27881257/economic-burden-of-osteoporotic-fracture-of-the-elderly-in-south-korea-a-national-survey
#5
Jinhyun Kim, Eunhee Lee, Sungjae Kim, Tae Jin Lee
BACKGROUND: Osteoporotic fractures (OFs) in the elderly are common worldwide, and the predicted number of the aging population is increasing the burden of OF on health care systems. OBJECTIVES: To estimate the economic burden of OF in people older than 65 years in South Korea from a societal perspective. METHODS: National Health Insurance claim databases were used to analyze health care utilization and medical costs of OF in the Korean population (49 million)...
May 2016: Value in Health Regional Issues
https://www.readbyqxmd.com/read/27870256/factors-related-to-a-decline-in-upper-extremity-function-among-patients-with-a-wrist-fracture-due-to-a-fall
#6
Nerea González, Ane Antón-Ladislao, Miren Orive, Jon Zabala, Susana García-Gutiérrez, Carlota Las Hayas, Jose Maria Quintana
AIMS: The aim of this study was to identify factors related to a decline in function following a wrist fracture. METHODS: Observational, prospective cohort study done in five public hospitals of the Basque Health Service. We recruited adults aged 65 or older with a wrist fracture due to a fall who attended the emergency department (ED) of one of these hospitals. Sociodemographic and clinical data were collected, along with information about health-related quality of life (HRQoL) and functionality...
November 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27824387/fler-utreddes-f%C3%A3-r-osteoporos-efter-inf%C3%A3-rande-av-frakturkedja
#7
Michael Lovric, Eva Ribom-Bornefalk
The aim of this retrospective study was to review the effect of a fracture liaison service (FLS) in terms of assessment and treatment of osteoporosis. An FLS is a model of care for improving the secondary preventive care of these patients. An FLS was started at Halland Hospital Halmstad in October 2013. In this study we evaluated the effect of the FLS on the follow up of patients with wrist fractures. In total 126 patients were included, equally divided in two groups before and after the implementation of the FLS...
November 1, 2016: Läkartidningen
https://www.readbyqxmd.com/read/27788215/comparison-of-diagnostic-accuracy-of-radiation-dose-equivalent-radiography-multidetector-computed-tomography-and-cone-beam-computed-tomography-for-fractures-of-adult-cadaveric-wrists
#8
Jakob Neubauer, Matthias Benndorf, Carolin Reidelbach, Tobias Krauß, Florian Lampert, Horst Zajonc, Elmar Kotter, Mathias Langer, Martin Fiebich, Sebastian M Goerke
PURPOSE: To compare the diagnostic accuracy of radiography, to radiography equivalent dose multidetector computed tomography (RED-MDCT) and to radiography equivalent dose cone beam computed tomography (RED-CBCT) for wrist fractures. METHODS: As study subjects we obtained 10 cadaveric human hands from body donors. Distal radius, distal ulna and carpal bones (n = 100) were artificially fractured in random order in a controlled experimental setting. We performed radiation dose equivalent radiography (settings as in standard clinical care), RED-MDCT in a 320 row MDCT with single shot mode and RED-CBCT in a device dedicated to musculoskeletal imaging...
2016: PloS One
https://www.readbyqxmd.com/read/27780801/persistent-user-bias-in-case-crossover-studies-in-pharmacoepidemiology
#9
Jesper Hallas, Anton Pottegård, Shirley Wang, Sebastian Schneeweiss, Joshua J Gagne
Studying the effect of chronic medication exposure by means of a case-crossover design may result in an upward-biased odds ratio. In this study, our aim was to assess the occurrence of this bias and to evaluate whether it is remedied by including a control group (the case-time-control design). Using Danish data resources from 1995-2012, we conducted case-crossover and case-time-control analyses for 3 medications (statins, insulin, and thyroxine) in relation to 3 outcomes (retinal detachment, wrist fracture, and ischemic stroke), all with assumed null associations...
October 25, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27770574/risks-consequences-and-prevention-of-falls-of-older-people-in-oral-healthcare-centers
#10
Cees de Baat, Paul de Baat, Anneloes E Gerritsen, Karien A Flohil, Gert-Jan van der Putten, Claar D van der Maarel-Wierink
One-third of community-dwelling people older than 65 years of age fall each year, and half of them fall at least twice a year. Older care home residents are approximately three times more likely to fall when compared to community-dwelling older people. Risk indicators for falls are related to the older people's body, environment, behavior, and activities. An important health risk indicator is (orthostatic or postprandial) hypotension, which may induce cerebral hypoperfusion. Although the majority of falls remain without major consequences, 10% to 25% of falls in care homes result in bodily trauma...
October 22, 2016: Special Care in Dentistry
https://www.readbyqxmd.com/read/27726000/cost-effectiveness-of-combined-oral-bisphosphonate-therapy-and-falls-prevention-exercise-for-fracture-prevention-in-the-usa
#11
T Mori, C J Crandall, D A Ganz
: We developed a Markov microsimulation model among hypothetical cohorts of community-dwelling US white women without prior major osteoporotic fractures over a lifetime horizon. At ages 75 and 80, adding 1 year of exercise to 5 years of oral bisphosphonate therapy is cost-effective at a conventionally accepted threshold compared with bisphosphonates alone. INTRODUCTION: The purpose of this study was to examine the cost-effectiveness of the combined strategy of oral bisphosphonate therapy for 5 years and falls prevention exercise for 1 year compared with either strategy in isolation...
October 11, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27697401/high-prevalence-of-dementia-in-women-with-osteoporosis
#12
Adamah Amouzougan, Ludovic Lafaie, Hubert Marotte, Delphine Dẻnariẻ, Philippe Collet, Béatrice Pallot-Prades, Thierry Thomas
INTRODUCTION: Alzheimer's disease or other Dementias (ADD) and postmenopausal osteoporosis are two major public health problems with a huge impact on mortality. Here, we examined the prevalence of ADD in postmenopausal women with osteoporosis, monitored within a dedicated fracture liaison service. METHODS: We conducted a cross-sectional observational study in a population of 2041 women, visiting the university hospital of Saint-Etienne for a peripheral fragility fracture...
September 30, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27664946/type-2-diabetes-and-risk-of-hip-fractures-and-non-skeletal-fall-injuries-in-the-elderly-a-study-from-the-fractures-and-fall-injuries-in-the-elderly-cohort-frailco
#13
Märit Wallander, Kristian Axelsson, Anna G Nilsson, Dan Lundh, Mattias Lorentzon
Questions remain about whether the increased risk of fractures in patients with type 2 diabetes (T2DM) is related mainly to increased risk of falling or to bone-specific properties. The primary aim of this study was to investigate the risk of hip fractures and non-skeletal fall injuries in older men and women with and without T2DM. We included 429,313 individuals (80.8 ± 8.2 years (mean ± SD), 58% women) from the Swedish registry "Senior Alert" and linked the data to several nation-wide registers...
September 24, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27649491/prediction-of-bone-mineral-density-and-fragility-fracture-by-genetic-profiling
#14
Thao P Ho-Le, Jacqueline R Center, John A Eisman, Hung T Nguyen, Tuan V Nguyen
AIM: Although the susceptibility to fracture is partly determined by genetic factors, the contribution of newly discovered genetic variants to fracture prediction is still unclear. This study sought to define the predictive value of a genetic profiling for fracture prediction. METHODS: Sixty-two bone mineral density (BMD)-associated single-nucleotide polymorphism (SNP) were genotyped in 557 men and 902 women who had participated in the Dubbo Osteoporosis Epidemiology Study...
September 20, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27614078/preferences-for-the-emergency-department-or-alternatives-for-older-people-in-aged-care-a-discrete-choice-experiment
#15
Glenn Arendts, Stephen Jan, Matthew J Beck, Kirsten Howard
OBJECTIVES: to estimate the effect of factors that influence decisions to transfer residents of aged care facilities to an emergency department (ED) for acute medical emergencies. DESIGN AND PARTICIPANTS: a discrete choice experiment with residents (N = 149), the relatives of residents (N = 137) and staff members (N = 128) of aged care facilities. SETTING: aged care facilities in three Australian states. OUTCOME MEASURES: using random parameter logit models, parameter estimates and odds ratios were estimated, and resultant utility functions for ED and alternate care were constructed...
September 10, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27595948/reasons-for-implant-removal-after-distal-radius-fractures
#16
Audrey Tan, Alphonsus Chong
BACKGROUND: With new low profile locked volar plate designs for distal radius fractures, soft tissue complications are uncommon. However, there are still patients who request to have their implants removed. In this study, we retrospectively reviewed the reasons for this. METHODS: We reviewed the hospital operative records of patients who had operative fixation of wrist fractures between November 2008 and May 2009. We examined the clinical records of these patients in order to ascertain if there was a difference in patient demographics between those who eventually had their implants removed and those who had their implants retained...
October 2016: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/27589491/gout-and-risk-of-fracture-in-women-a-prospective-cohort-study
#17
Julie M Paik, Seoyoung C Kim, Diane Feskanich, Hyon K Choi, Daniel H Solomon, Gary C Curhan
OBJECTIVE: Uric acid may be linked to bone health through its anti-oxidant or pro-oxidant effects, thereby affecting bone resorption and formation, or through inhibition of vitamin D activation and higher parathyroid hormone level. Prior studies on the relation between uric acid and bone mineral density have demonstrated conflicting results. To date, there are no prospective studies examining the relation between gout, a disease characterized by hyperuricemia and inflammation, and hip or wrist fracture risk in women...
September 2, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27581955/evaluation-on-the-cost-effective-threshold-of-osteoporosis-treatment-on-elderly-women-in-china-using-discrete-event-simulation-model
#18
W Ni, Y Jiang
: This study used a simulation model to determine the cost-effective threshold of fracture risk to treat osteoporosis among elderly Chinese women. Osteoporosis treatment is cost-effective among average-risk women who are at least 75 years old and above-average-risk women who are younger than 75 years old. INTRODUCTION: Aging of the Chinese population is imposing increasing economic burden of osteoporosis. This study evaluated the cost-effectiveness of osteoporosis treatment among the senior Chinese women population...
August 31, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27548843/patterns-of-prescription-drug-use-before-and-after-fragility-fracture
#19
Jeffrey C Munson, Julie P W Bynum, John-Erik Bell, Robert Cantu, Christine McDonough, Qianfei Wang, Tor D Tosteson, Anna N A Tosteson
Importance: Patients who have a fragility fracture are at high risk for subsequent fractures. Prescription drugs represent 1 factor that could be modified to reduce the risk of subsequent fracture. Objective: To describe the use of prescription drugs associated with fracture risk before and after fragility fracture. Design, Setting, and Participants: Retrospective cohort study conducted between February 2015 and March 2016 using a 40% random sample of Medicare beneficiaries from 2007 through 2011 in general communities throughout the United States...
October 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27543401/return-to-play-after-hand-and-wrist-fractures
#20
REVIEW
Andrea Halim, Arnold-Peter C Weiss
Wrist and hand injuries are common among athletes, and can lead to considerable disability. Dislocations and soft tissue injuries are common and require prompt recognition and treatment. Accurate diagnosis and early immobilization are often key to getting players back to their sport early. Some injuries require surgery; operative intervention allows the player to return to their sport more quickly or with less long-term disability. This article discusses the spectrum of injury from distal radius fractures to mallet fingers, and offers some general guidelines for the surgeon in how to counsel and treat athletes with these problems...
October 2016: Clinics in Sports Medicine
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