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"Spinal cord injury"

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https://www.readbyqxmd.com/read/28742157/angiotensin-ii-system-in-the-nucleus-tractus-solitarii-contributes-to-autonomic-dysreflexia-in-rats-with-spinal-cord-injury
#1
Kai Wang, Shaoxia Duan, Xueping Wen, Weizhong Wang, Shangping Fang, Dunyi Qi, Xiang Huan, Liwei Wang, Zhenzhou He
BACKGROUND: Autonomic dysreflexia (AD) is a potentially life-threating complication after spinal cord injury (SCI), characterized by episodic hypertension induced by colon or bladder distension. The objective of this study was to determine the role of impaired baroreflex regulation by the nucleus tractus solitarii(NTS) in the occurrence of AD in a rat model. METHODS: T4 spinal cord transection animal model was used in this study, which included 40 Male rats Colorectal distension (CD) was performed to assess AD and compare the changes of BP, HR, and BRS, six weeks after operation...
2017: PloS One
https://www.readbyqxmd.com/read/28741434/robot-applied-resistance-augments-the-effects-of-body-weight-supported-treadmill-training-on-stepping-and-synaptic-plasticity-in-a-rodent-model-of-spinal-cord-injury
#2
Erika Hinahon, Christina Estrada, Lin Tong, Deborah S Won, Ray D de Leon
BACKGROUND: The application of resistive forces has been used during body weight-supported treadmill training (BWSTT) to improve walking function after spinal cord injury (SCI). Whether this form of training actually augments the effects of BWSTT is not yet known. OBJECTIVE: To determine if robotic-applied resistance augments the effects of BWSTT using a controlled experimental design in a rodent model of SCI. METHODS: Spinally contused rats were treadmill trained using robotic resistance against horizontal (n = 9) or vertical (n = 8) hind limb movements...
July 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28740568/methane-suppresses-microglial-activation-related-to-oxidative-inflammatory-and-apoptotic-injury-during-spinal-cord-injury-in-rats
#3
WeiHeng Wang, Xiaodong Huang, Jian Li, Aijun Sun, Jiangming Yu, Ning Xie, YanHai Xi, Xiaojian Ye
OBJECTIVE: We investigated the hypothesis that methane-rich saline (MS) can be used to repair spinal cord injury (SCI) in a rat model through suppressing microglial activation related to oxidative, inflammatory, and apoptotic injury. METHODS: MS was injected intraperitoneally in rats after SCI. Hematoxylin-eosin (HE) staining, oxidative stress, inflammatory parameters, and cell apoptosis were detected 72 h after SCI to determine the optimal dose. Then, we investigated the protective mechanisms and the long-term effects of MS on SCI...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28739558/design-of-mobile-health-tools-to-promote-goal-achievement-in-self-management-tasks
#4
Brad Edward Dicianno, Geoffrey Henderson, Bambang Parmanto
BACKGROUND: Goal-setting within rehabilitation is a common practice ultimately geared toward helping patients make functional progress. OBJECTIVE: The purposes of this study were to (1) qualitatively analyze data from a wellness program for patients with spina bifida (SB) and spinal cord injury (SCI) in order to generate software requirements for a goal-setting module to support their complex goal-setting routines, (2) design a prototype of a goal-setting module within an existing mobile health (mHealth) system, and (3) identify what educational content might be necessary to integrate into the system...
July 24, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28739474/traumatic-subaxial-cervical-facet-subluxation-and-dislocation-epidemiology-radiographic-analyses-and-risk-factors-for-spinal-cord-injury
#5
Ryan D Quarrington, Claire F Jones, Petar Tcherveniakov, Jillian M Clark, Simon J I Sandler, Yu Chao Lee, Shabnam Torabiardakani, John J Costi, Brian J C Freeman
BACKGROUND CONTEXT: Distractive-flexion injuries (DFIs) of the subaxial cervical spine are major contributors to spinal cord injury (SCI). Prompt assessment and early intervention of DFIs associated with SCI is crucial to optimize patient outcome; however, neurological examination of patients with subaxial cervical injury is often difficult, as patients commonly present with reduced levels of consciousness. Therefore, it is important to establish potential associations between injury epidemiology and radiographic features, and neurological involvement...
July 21, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28739349/autophagy-protects-against-pi3k-akt-mtor-mediated-apoptosis-of-spinal-cord-neurons-after-mechanical-injury
#6
ZhenYu Wang, LinQuan Zhou, XiaoTing Zheng, Gang Chen, RongFeng Pan, JinHuang Li, WenGe Liu
Many studies have indicated that autophagy and apoptosis play an important role in the pathogenesis of spinal cord injury. In recent years, research on autophagy-related signal transduction pathways has demonstrated that the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway is closely associated with the initiation of autophagy. However, the mechanism of the pathological relationship between this signaling pathway and apoptosis in spinal cord injury is unclear...
July 21, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28738759/views-of-individuals-with-spinal-cord-injury-on-the-use-of-wearable-cameras-to-monitor-upper-limb-function-in-the-home-and-community
#7
Jirapat Likitlersuang, Elizabeth R Sumitro, Pirashanth Theventhiran, Sukhvinder Kalsi-Ryan, José Zariffa
OBJECTIVE: Hand function impairment after cervical spinal cord injury (SCI) can significantly reduce independence. Unlike current hand function assessments, wearable camera systems could potentially measure functional hand usage at home, and thus benefit the development of neurorehabilitation strategies. The objective of this study was to understand the views of individuals with SCI on the use of wearable cameras to track neurorehabilitation progress and outcomes in the community. DESIGN: Questionnaires...
July 24, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28738744/pain-profiles-in-a-community-dwelling-population-following-spinal-cord-injury-a-national-survey
#8
Dearbhla Burke, Brona M Fullen, Olive Lennon
CONTEXT: While as many as 60% of patients with spinal cord injury (SCI) develop chronic pain, limited data currently exists on the prevalence and profile of pain post-SCI in community dwelling populations. STUDY DESIGN: A cross-sectional population survey. SETTING: Primary care. PARTICIPANTS: Community dwelling adults with SCI. METHODS: Following ethical approval members registered to a national SCI database (n=1,574) were surveyed...
July 24, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28738740/a-systematic-review-of-the-effectiveness-of-task-specific-rehabilitation-interventions-for-improving-independent-sitting-and-standing-function-in-spinal-cord-injury
#9
Cynthia M Tse, Amanda E Chisholm, Tania Lam, Janice J Eng
Context Impaired balance function after a spinal cord injury (SCI) hinders performance of daily activities. Objective To assess the evidence on the effectiveness of task-specific training on sitting and standing function in individuals with SCI across the continuum of care. Methods A systematic search was conducted on literature published to June 2016 using people (acute or chronic SCI), task-specific interventions compared to conventional physical therapy, and outcome (sitting or standing balance function)...
July 24, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28737515/cell-biology-of-spinal-cord-injury-and-repair
#10
Timothy M O'Shea, Joshua E Burda, Michael V Sofroniew
Spinal cord injury (SCI) lesions present diverse challenges for repair strategies. Anatomically complete injuries require restoration of neural connectivity across lesions. Anatomically incomplete injuries may benefit from augmentation of spontaneous circuit reorganization. Here, we review SCI cell biology, which varies considerably across three different lesion-related tissue compartments: (a) non-neural lesion core, (b) astrocyte scar border, and (c) surrounding spared but reactive neural tissue. After SCI, axon growth and circuit reorganization are determined by neuron-cell-autonomous mechanisms and by interactions among neurons, glia, and immune and other cells...
July 24, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28737113/micrornas-roles-in-regulating-neuroinflammation
#11
Andrew D Gaudet, Laura K Fonken, Linda R Watkins, Randy J Nelson, Phillip G Popovich
MicroRNAs (miRNAs) are small noncoding RNAs that broadly affect cellular and physiological function in all multicellular organisms. Here, the role of miRNAs in neuroinflammation is considered. miRNAs are 21- to 23-oligonucleotide RNAs that regulate translation of specific RNAs by binding to complementary regulatory RNA sequences, thereby causing mRNA degradation or sequestration. More than 5000 miRNAs likely exist in humans, and each miRNA binds an average of 200 RNAs. Specific immunomodulatory miRNAs can regulate a set of RNAs in a coordinated manner, suggesting that effective miRNA-based therapeutic manipulations for neuroinflammatory conditions may be revealed...
July 1, 2017: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/28736791/control-of-standing-balance-at-leaning-postures-with-functional-neuromuscular-stimulation-following-spinal-cord-injury
#12
Musa L Audu, Brooke M Odle, Ronald J Triolo
This study systematically explored the potential of applying feedback control of functional neuromuscular stimulation (FNS) for stabilizing various erect and leaning standing postures after spinal cord injury (SCI). Perturbations ranging from 2 to 6% body weight were applied to two subjects with motor complete thoracic level SCI who were proficient at standing with implanted multichannel neural stimulators to activate the ankle, knee, hip and trunk muscles. The subjects stood with four different postures: erect, forward, forward-right and forward-left...
July 24, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28735026/regulated-viral-bdnf-delivery-in-combination-with-schwann-cells-promotes-axonal-regeneration-through-capillary-alginate-hydrogels-after-spinal-cord-injury
#13
Shengwen Liu, Beatrice Sandner, Thomas Schackel, LaShae Nicholson, Abdelwahed Chtarto, Liliane Tenenbaum, Radhika Puttagunta, Rainer Müller, Norbert Weidner, Armin Blesch
Grafting of cell-seeded alginate capillary hydrogels into a spinal cord lesion site provides an axonal bridge while physically directing regenerating axonal growth in a linear pattern. However, without an additional growth stimulus, bridging axons fail to extend into the distal host spinal cord. Here we examined whether a combinatory strategy would support regeneration of descending axons across a cervical (C5) lateral hemisection lesion in the rat spinal cord. Following spinal cord transections, Schwann cell (SC)-seeded alginate hydrogels were grafted to the lesion site and AAV5 expressing brain-derived neurotrophic factor (BDNF) under control of a tetracycline-regulated promoter was injected caudally...
July 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28734802/co-transplantation-of-mesenchymal-and-neural-stem-cells-and-overexpressing-stromal-derived-factor-1-for-treating-spinal-cord-injury
#14
Andrew N Stewart, Griffin Kendziorski, Zachary M Deak, Dara J Brown, Matthew N Fini, Katherine L Copely, Julien Rossignol, Gary L Dunbar
Genetic engineering of mesenchymal stem cells (MSCs) and neuronal stem cells (NSCs) has been used to treat spinal cord injuries (SCI). As a mechanism of therapy, MSCs secrete high amounts of anti-inflammatory cytokines and trophic factors, while NSCs can differentiate into neuronal lineages and aid in tissue replacement. Additionally, the forced overexpression of secreted proteins can enhance the secretome of transplanted cells, which can increase therapeutic efficacy. This study utilized a combinational treatment consisting of MSCs, NSCs, and the forced overexpression of the chemokine stromal-derived factor-1 (SDF-1) from MSCs (SDF-1-MSCs), to treat a rat model of SCI...
July 19, 2017: Brain Research
https://www.readbyqxmd.com/read/28734171/muscle-synergies-reveal-impaired-trunk-muscle-coordination-strategies-in-individuals-with-thoracic-spinal-cord-injury
#15
Matija Milosevic, Hikaru Yokoyama, Murielle Grangeon, Kei Masani, Milos R Popovic, Kimitaka Nakazawa, Dany H Gagnon
Spinal cord injury (SCI) can result in paralysis of trunk muscles, which can affect sitting balance. The objective of this study was to analyze trunk muscle coordination of individuals with thoracic SCI and compare it to able-body individuals. A total of 27 individuals were recruited and subdivided into: (a) high thoracic SCI; (b) low thoracic SCI; and (c) able-body groups. Participants were seated and asked to lean their trunk in eight directions while trunk muscle activity was recorded. Muscle coordination was assessed using the non-negative matrix factorization (NMF) method to extract muscle modules, which are the synergistic trunk muscle activations, and their directional activation patterns...
July 1, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28733344/effects-of-exercise-on-fitness-and-health-of-adults-with-spinal-cord-injury-a-systematic-review
#16
REVIEW
Jan W van der Scheer, Kathleen A Martin Ginis, David S Ditor, Victoria L Goosey-Tolfrey, Audrey L Hicks, Christopher R West, Dalton L Wolfe
OBJECTIVE: To synthesize and appraise research testing the effects of exercise interventions on fitness, cardiometabolic health, and bone health among adults with spinal cord injury (SCI). METHODS: Electronic databases were searched (1980-2016). Included studies employed exercise interventions for a period ≥2 weeks, involved adults with acute or chronic SCI, and measured fitness (cardiorespiratory fitness, power output, or muscle strength), cardiometabolic health (body composition or cardiovascular risk factors), or bone health outcomes...
July 21, 2017: Neurology
https://www.readbyqxmd.com/read/28732686/health-conditions-impact-on-function-health-related-quality-of-life-and-life-satisfaction-following-traumatic-spinal-cord-injury-a-prospective-observational-registry-cohort-study
#17
Carly S Rivers, Nader Fallah, Vanessa K Noonan, David Gt Whitehurst, Carolyn Schwartz, Joel Finkelstein, B Catharine Craven, Karen Ethans, Colleen O'Connell, Catherine Truchon, Chester Ho, A Gary Linassi, Christine Short, Eve Tsai, Brian Drew, Henry Ahn, Marcel F Dvorak, Jérôme Paquet, Michael G Fehlings, Luc Noreau
OBJECTIVE: To analyze relationships among injury, demographic and environmental factors on function, HRQoL and life satisfaction in individuals with traumatic SCI. DESIGN: prospective observational registry cohort study SETTING: 31 acute and rehabilitation SCI centres PARTICIPANTS: Participants (N=340) from the Rick Hansen Spinal Cord Injury Registry (RHSCIR) who were prospectively recruited from 2004-2014 were included. The model cohort included 340 participants: 79...
July 18, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28732510/protective-and-therapeutic-role-of-2-carba-cyclic-phosphatidic-acid-in-demyelinating-disease
#18
Shinji Yamamoto, Kota Yamashina, Masaki Ishikawa, Mari Gotoh, Sosuke Yagishita, Kensuke Iwasa, Kei Maruyama, Kimiko Murakami-Murofushi, Keisuke Yoshikawa
BACKGROUND: Multiple sclerosis is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by recurrent and progressive demyelination/remyelination cycles, neuroinflammation, oligodendrocyte loss, demyelination, and axonal degeneration. Cyclic phosphatidic acid (cPA) is a natural phospholipid mediator with a unique cyclic phosphate ring structure at the sn-2 and sn-3 positions of the glycerol backbone. We reported earlier that cPA elicits a neurotrophin-like action and protects hippocampal neurons from ischemia-induced delayed neuronal death...
July 21, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28731391/malpractice-litigation-following-spine-surgery
#19
Alan H Daniels, Roy Ruttiman, Adam E M Eltorai, J Mason DePasse, Bielinsky A Brea, Mark A Palumbo
OBJECTIVE Adverse events related to spine surgery sometimes lead to litigation. Few studies have evaluated the association between spine surgical complications and medical malpractice proceedings, outcomes, and awards. The aim of this study was to identify the most frequent causes of alleged malpractice in spine surgery and to gain insight into patient demographic and clinical characteristics associated with medical negligence litigation. METHODS A search for "spine surgery" spanning February 1988 to May 2015 was conducted utilizing the medicolegal research service VerdictSearch (ALM Media Properties, LLC)...
July 21, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28731189/identification-of-pivotal-genes-and-pathways-for-spinal-cord-injury-via-bioinformatics-analysis
#20
Zonghao Zhu, Qiang Shen, Liang Zhu, Xiaokang Wei
The present study aimed to identify key genes and pathways associated with spinal cord injury (SCI) and subsequently investigate possible therapeutic targets for the condition. The array data of GSE20907 was downloaded from the Gene Expression Omnibus database and 24 gene chips, including 3‑day, 4‑day, 1‑week, 2‑week and 1‑month post‑SCI together with control propriospinal neurons, were used for the analysis. The raw data was normalized and then the differentially expressed genes (DEGs) in the (A) 2‑week post‑SCI group vs...
July 21, 2017: Molecular Medicine Reports
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