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https://www.readbyqxmd.com/read/29031640/the-application-of-mesenchymal-stem-cells-to-treat-thermal-and-radiation-burns
#1
Kathleen Rodgers, Sachin S Jadhav
Mesenchymal stem cells (MSCs) have been developed for a number of indications due to their regenerative and anti-inflammatory phenotypes and their utility is enhanced by the fact that allogeneic transplant is feasible with this cell type. Animal studies and early human cases indicate this has the potential to be an exciting new therapy for treating chronic non-healing wounds such as diabetic ulcers, burns and cutaneous radiation burns. This review will focus on the use of MSCs to treat thermal and radiation burns...
October 11, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28854522/an-investigation-on-effects-of-amputee-s-physiological-parameters-on-maximum-pressure-developed-at-the-prosthetic-socket-interface-using-artificial-neural-network
#2
Chitresh Nayak, Amit Singh, Himanshu Chaudhary, Deepak Rajendra Unune
Technological advances in prosthetics have attracted the curiosity of researchers in monitoring design and developments of the sockets to sustain maximum pressure without any soft tissue damage, skin breakdown, and painful sores. Numerous studies have been reported in the area of pressure measurement at the limb/socket interface, though, the relation between amputee's physiological parameters and the pressure developed at the limb/socket interface is still not studied. Therefore, the purpose of this work is to investigate the effects of patient-specific physiological parameters viz...
August 1, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28808084/glycopyrronium-for-severe-drooling-in-children
#3
(no author information available yet)
Drooling of saliva is common in children with physical, intellectual and learning disability, and with poor neuromuscular coordination and oral control.(1) It can cause skin breakdown, damage to clothes and equipment and psychosocial problems for the child and family. For many years, glycopyrronium has been prescribed off-label using the injection solution given orally or tablets crushed and suspended in water, or as unlicensed products that were imported or manufactured as pharmaceutical specials.(2,3) In January 2017, a glycopyrronium oral solution (Sialanar-Proveca Limited) became available in the UK as the first licensed product for the treatment of severe drooling (sialorrhoea) in children and adolescents aged 3 years and older with chronic neurological disorders...
August 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28807988/high-flow-nasal-cannula-therapy-versus-intermittent-noninvasive-ventilation-in-obese-subjects-after-cardiothoracic-surgery
#4
François Stéphan, Laurence Bérard, Saida Rézaiguia-Delclaux, Priscilla Amaru
BACKGROUND: Obese patients are considered at risk of respiratory failure after cardiothoracic surgery. High-flow nasal cannula has demonstrated its non-inferiority after cardiothoracic surgery compared to noninvasive ventilation (NIV), which is the recommended treatment in obese patients. We hypothesized that NIV was superior to high-flow nasal cannula for preventing or resolving acute respiratory failure after cardiothoracic surgery in this population. METHODS: We performed a post hoc analysis of a randomized, controlled trial...
August 14, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28779991/surgical-management-of-adult-acquired-buried-penis-escutcheonectomy-scrotectomy-and-penile-split-thickness-skin-graft
#5
Thomas W Fuller, Katherine Theisen, Paul Rusilko
OBJECTIVE: To demonstrate the surgical management of adult acquired buried penis (AABP). Affected patients have poor sexual function, urinary dribbling with subsequent skin breakdown, mood disturbance, lichen sclerosus with subsequent urethral stricture, and poor quality of life. Previous efforts have described limited repairs including an isolated resection of the escutcheon, which unfortunately often leads to reburying. We present a more extensive surgical repair including escutcheonectomy, scrotoplasty, and penile split-thickness skin graft (STSG) to provide a durable definitive repair...
July 6, 2017: Urology
https://www.readbyqxmd.com/read/28736002/high-flow-nasal-cannula-versus-noninvasive-ventilation-for-treatment-of-acute-hypoxemic-respiratory-failure-in-renal-transplant-recipients
#6
G Tu, H He, K Yin, M Ju, Y Zheng, D Zhu, Z Luo
OBJECTIVE: This study aimed to evaluate the outcomes of high-flow nasal cannula (HFNC) oxygen therapy compared with noninvasive ventilation (NIV) for the treatment of acute hypoxemic respiratory failure in renal transplant recipients. METHODS: Data were retrospectively collected from a tertiary intensive care unit (ICU) from July 1, 2011, to September 31, 2015. All renal recipients who had acute respiratory failure at that period of time were classified into the HFNC or NIV group depending on the initial form of respiratory support...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28719546/fracture-table-application-for-pediatric-femur-fractures-incidence-and-risk-factors-associated-with-adverse-outcomes
#7
Brian A Kelly, Manahil Naqvi, Emily S Rademacher, Patricia E Miller, Daniel J Hedequist, Michael P Glotzbecker, Travis H Matheney, Benjamin J Shore
BACKGROUND: Flexible elastic nails, submuscular plating, and rigid locked intramedullary nails are common methods of fixation for pediatric femur fractures (PFF) in which the fracture table is used to aid reduction. Little is known about complications associated with fracture table application in PFF. The purpose of this study was to determine the incidence and risk factors associated with adverse outcomes related to fracture table application for the treatment of PFF. METHODS: A retrospective chart review of all children (younger than 18 y) treated for a femur fracture with the use of the fracture table between 2004 and 2015 at a single tertiary pediatric hospital was performed...
July 17, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28719403/passive-transcutaneous-bone-conduction-hearing-implants-a-systematic-review
#8
Timothy Cooper, Brendan McDonald, Allan Ho
OBJECTIVE: To systematically review the literature on currently available passive transcutaneous bone conduction hearing implants (pTCBI) with regard to complications, audiological outcomes, and quality-of-life scores. DATA SOURCES: MEDLINE, EMBASE, Scopus, and Cochrane Library. STUDY SELECTION: All identified English-language articles reporting on the implantation of currently available pTCBI's and their complications. Both pediatric and adult patients were included...
October 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28650945/treatment-approach-for-infection-of-healed-fractures-after-internal-fixation
#9
Joshua M Lawrenz, Salvatore J Frangiamore, Ajinkya A Rane, W Alex Cantrell, Heather A Vallier
OBJECTIVE: To review the efficacy of a treatment approach for patients with infection and colonized implants after open reduction and internal fixation of fractures. DESIGN: Retrospective case series. SETTING: Level one trauma center. PATIENTS: Twenty patients were treated for wound infection with colonized implants after open reduction and internal fixation. INTERVENTION: Surgical debridement, removal of implants and a short post-operative oral antibiotic course...
June 15, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28633785/the-lisfranc-amputation-a-more-reliable-level-of-amputation-with-proper-intraoperative-tendon-balancing
#10
Christopher J Greene, Christopher Bibbo
Traditional transmetatarsal amputations are a reliable level of amputation. However, amputations at the Lisfranc level have met with limited success owing to improper biomechanics resulting from tendon imbalance, ultimately leading to foot deformity positions and an unstable soft tissue envelope with ensuing skin breakdown, infection, and below-the-knee amputation. We describe proper tendon rebalancing that results in improved biomechanics and a more reliable and stable amputation at the more proximal Lisfranc level...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28617750/skin-and-wound-care-in-lymphedema-patients-a-taxonomy-primer-and-literature-review
#11
Caroline E Fife, Wade Farrow, Adelaide A Hebert, Nathan C Armer, Bob R Stewart, Janice N Cormier, Jane M Armer
BACKGROUND: Lymphedema is a condition of localized protein-rich swelling from damaged or malfunctioning lymphatics. Because the immune system is compromised, there is a high risk of infection. Infection in patients with lymphedema may present in a variety of ways. OBJECTIVE: The goals of this review were to standardize the terminology of skin breakdown in the context of lymphedema, synthesize the available information to create best practice recommendations in support of the American Lymphedema Framework Project update to its Best Practices document, and create recommendations for further research...
July 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28586092/quantitative-skin-assessment-using-spatial-frequency-domain-imaging-sfdi-in-patients-with-or-at-high-risk-for-pressure-ulcers
#12
Amr Yafi, Fuad K Muakkassa, Tejasvi Pasupneti, Judy Fulton, David J Cuccia, Amaan Mazhar, Kimberly N Blasiole, Eliot N Mostow
BACKGROUND AND OBJECTIVE: Pressure ulcers (PU) are a significant problem facing the health system in the United States. Here, we present preliminary case studies demonstrating feasibility of Spatial Frequency Domain Imaging (SFDI) to assess skin status in high-risk populations and pre-existing wounds. SFDI is a wide-field non-contact optical imaging technology that uses structured light to obtain tissue optical properties and of tissue constituents. This study aims to determine the fit of SFDI for PU care and determine the next steps...
June 6, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28583488/non-invasive-methods-to-maintain-cervical-spine-position-after-pediatric-tracheal-resections
#13
Kahren K Aydinyan, Jonathan D Day, Gina M Troiano, G Paul Digoy
OBJECTIVES: To present our experience with two methods of neck stabilization after pediatric tracheal resection with primary anastomosis as possible alternatives to the traditional chest-chin suture. METHODS: Children undergoing tracheal resection and/or cricotracheal resection with anastomosis under tension were placed in cervical spine flexion postoperatively with either a chest-chin (Grillo) suture, an Aspen cervical collar or Trulife Johnson cervical-thoracic orthosis (CTO)...
July 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28578999/utility-and-tolerability-of-the-long-pulsed-1064-nm-neodymium-yttrium-aluminum-garnet-lp-nd-yag-laser-for-treatment-of-symptomatic-or-disfiguring-vascular-malformations-in-children-and-adolescents
#14
Aditi S Murthy, Annelise Dawson, Deepti Gupta, Shanna Spring, Kelly M Cordoro
BACKGROUND: Vascular malformations manifest with pain, bleeding, disability, and disfigurement in a subset of children. There are scant data available on the utility and tolerability of laser surgery for symptomatic or disfiguring non-port-wine stain vascular malformations in children. OBJECTIVE: The objective of this study was to determine the utility and tolerability of the 1064-nm long-pulsed neodymium:yttrium-aluminum-garnet (LP Nd:YAG) laser for treatment of symptomatic or disfiguring vascular malformations in children...
June 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28480522/a-randomized-controlled-trial-of-velcro-versus-standard-twill-ties-following-pediatric-tracheotomy
#15
RANDOMIZED CONTROLLED TRIAL
Catherine K Hart, Kareem O Tawfik, Jareen Meinzen-Derr, John Drew Prosser, Cheryl Brumbaugh, Amy Myer, Jonette A Ward, Alessandro de Alarcon
OBJECTIVES/HYPOTHESIS: Tracheotomy is a common procedure. A reliable method of securing the tracheotomy tube is essential to minimize accidental decannulation. However, skin breakdown has been reported in ∼30% of patients. We sought to evaluate rates of skin-related complications and accidental decannulation with the use of Velcro ties compared to twill ties. STUDY DESIGN: A nonblinded, randomized controlled trial comparing Velcro versus twill ties in patients undergoing tracheotomy between July 1, 2014 and January 31, 2016...
September 2017: Laryngoscope
https://www.readbyqxmd.com/read/28379094/inaugural-professorial-lecture-found-in-translation
#16
(no author information available yet)
Using a multidisciplinary, patient-centric approach work over two decades has led to the many advances made by Professor Patricia Grocott during her academic career at Kings College London (KCL). In her inaugural lecture as Professor of Nursing Technology and Innovation, Grocott recalls her work and inspirations, from her prosthetics for a large nodule wound to her current projects, which involve codesigning medical devices and technologies with patients vulnerable to skin breakdown. Her collaboration with an openness to other disciplines has enabled her work to cross boundaries and improve patients' quality of life and outcomes...
April 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28273390/purpureocillium-lilacinum-tattoo-related-skin-infection-in-a-kidney-transplant-recipient
#17
Sonya A Trinh, Michael P Angarone
Purpureocillium lilacinum is an emerging pathogenic mold among immunocompromised hosts that causes cutaneous infections related to skin breakdown. We present the first reported case of P. lilacinum tattoo-related skin infection, to our knowledge. A kidney transplant recipient recently treated for acute cellular rejection presented with skin papules overlying a tattoo. Diagnosis was confirmed on culture, histology, and 18S ribosomal RNA polymerase chain reaction. The morphological features on culture characteristic of P...
June 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28267125/clinical-evaluation-of-a-skin-protectant-for-the-management-of-incontinence-associated-dermatitis-an-open-label-nonrandomized-prospective-study
#18
Mary R Brennan, Catherine T Milne, Marie Agrell-Kann, Bruce P Ekholm
PURPOSE: The purpose of this study was to evaluate the efficacy of an investigational skin protectant product at managing severe skin breakdown associated with incontinence. DESIGN: Open-label, nonrandomized, prospective study. SUBJECTS AND SETTING: The sample comprised 16 patients; inclusion criteria were: patients older than 18 years, cared for in the intensive care unit of a level I trauma center hospital or in long-term care facilities in the northeast region of the United States, and had incontinence-associated dermatitis (IAD)...
March 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28265895/clinical-peritonitis-from-allergy-to-silicone-ventriculoperitoneal-shunt
#19
Michael Kurin, Kenneth Lee, Paul Gardner, Merritt Fajt, Chandraprakash Umapathy, Kenneth Fasanella
Silicones are inorganic compounds that have been used for the purpose of shunting ventricular fluid since the mid-20th century [1]. Complications of ventriculoperitoneal shunts have rarely been attributed to silicone allergy, with only a handful of cases reported in literature. The classic presentation of allergy to silicone ventriculoperitoneal shunt, i.e., abdominal pain with recurrent skin breakdown along the shunt tract, is nonspecific and difficult to distinguish clinically from other causes of shunt-related symptoms...
June 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28243502/ceeg-electrode-related-pressure-ulcers-in-acutely-hospitalized-patients
#20
Lidia M V R Moura, Thiago S Carneiro, David Kwasnik, Valdery F Moura, Christine S Blodgett, Joseph Cohen, Mary McKenna Guanci, Daniel B Hoch, John Hsu, Andrew J Cole, M Brandon Westover
BACKGROUND: Pressure ulcers resulting from continuous EEG (cEEG) monitoring in hospitalized patients have gained attention as a preventable medical complication. We measured their incidence and risk factors. METHODS: We performed an observational investigation of cEEG-electrode-related pressure ulcers (EERPU) among acutely ill patients over a 22-month period. Variables analyzed included age, sex, monitoring duration, hospital location, application methods, vasopressor usage, nutritional status, skin allergies, fever, and presence/severity of EERPU...
February 2017: Neurology. Clinical Practice
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