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https://www.readbyqxmd.com/read/28422894/impact-of-telephone-based-problem-solving-treatment-on-the-use-of-medical-and-psychological-services-in-the-military
#1
John S Richardson, Jesse R Fann, Kathleen R Bell, Nancy Temkin
OBJECTIVE: To explore the impact of problem-solving treatment (PST) for mild traumatic brain injury in active duty service members on the use of medical and psychological services. PARTICIPANTS: Service members who had a mild traumatic brain injury during their last deployment and enrolled in the CONcussion Treatment After Combat Trauma (CONTACT) study. DESIGN: Secondary analysis of a randomized clinical trial. Participants were assigned to telephone-based PST, or e-mailed or mailed education only over the course of 6 months...
April 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28422893/do-concussive-symptoms-really-resolve-in-young-children
#2
Coco O Bernard, Jennie L Ponsford, Audrey McKinlay, Dean McKenzie, David Krieser
OBJECTIVES: To examine the frequency and nature of postconcussive symptoms (PCSs) and behavioral outcomes in young children following mild traumatic brain injury (mTBI) or concussion. SETTING: Emergency department. PARTICIPANTS: Children aged 2 to 12 years presenting with either a concussion or minor bodily injury (control). OUTCOME MEASUREMENT: Parent ratings of PCS were obtained within 72 hours of injury, at 1 week, and 1, 2, and 3 months postinjury using a comprehensive PCS checklist...
April 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28414250/longitudinal-changes-in-brain-morphology-from-4-weeks-to-12-months-after-mild-traumatic-brain-injury-associations-with-cognitive-functions-and-clinical-variables
#3
T Hellstrom, L T Westlye, S Sigurdardottir, C Brunborg, H L Soberg, Ø Holthe, A Server, M J Lund, O A Andreassen, N Andelic
OBJECTIVE: To investigate longitudinal changes in cortical and subcortical volumes in patients with mild traumatic brain injury (MTBI) and to evaluate whether such changes were associated with self-reported post-concussive symptoms, global functional outcomes and neuropsychological functioning. METHODS: This was a prospecitve, longitudinal cohort study of patients with complicated (i.e presence of intracranial abnormalities on the day of injury CT) and uncomplicated MTBI (i...
April 17, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28412305/memantine-improves-outcomes-after-repetitive-traumatic-brain-injury
#4
Zhengrong Mei, Jianhua Qiu, Sasha Alcon, Jumana Hashim, Alexander Rotenberg, Yan Sun, William P Meehan, Rebekah Mannix
Repetitive mild traumatic brain injury (rmTBI; e.g., sports concussions) is common and results in significant cognitive impairment. Targeted therapies for rmTBI are lacking, though evidence from other injury models indicates that targeting N-methyl-d-aspartate (NMDA) receptor (NMDAR)-mediated glutamatergic toxicity might mitigate rmTBI-induced neurologic deficits. However, there is a paucity of preclinical or clinical data regarding NMDAR antagonist efficacy in the rmTBI setting. To test whether NMDAR antagonist therapy improves outcomes after rmTBI, mice were subjected to rmTBI injury (4 injuries in 4 days) and randomized to treatment with the NMDA antagonist memantine or with vehicle...
April 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28412141/toll-like-receptor-4-activation-can-be-either-detrimental-or-beneficial-following-mild-repetitive-traumatic-brain-injury-depending-on-timing-of-activation
#5
Frances Corrigan, Alina Arulsamy, Lyndsey E Collins-Praino, Joshua L Holmes, Robert Vink
A history of repeated concussion has been linked to the later development of neurodegeneration, which is associated with the accumulation of hyperphosphorylated tau and the development of behavioral deficits. However, the role that exogenous factors, such as immune activation, may play in the development of neurodegeneration following repeated mild traumatic brain injury (rmTBI) has not yet been explored. To investigate, male Sprague-Dawley rats were administered three mTBIs 5 days apart using the diffuse impact-acceleration model to generate ∼100G...
April 13, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28404801/serum-neurofilament-light-as-a-biomarker-for-mild-traumatic-brain-injury-in-contact-sports
#6
Pashtun Shahim, Henrik Zetterberg, Yelverton Tegner, Kaj Blennow
OBJECTIVE: To evaluate whether the axonal protein neurofilament light (NFL) in serum is a sensitive biomarker to detect subtle brain injury or concussion in contact sports athletes. METHODS: Two prospective cohort studies involving (1) 14 Swedish amateur boxers who underwent fluid biomarker assessments at 7-10 days after bout and after 3 months of rest from boxing and (2) 35 Swedish professional hockey players who underwent blood biomarker assessment at 1, 12, 36, and 144 hours after concussion and when the players returned to play were performed...
April 12, 2017: Neurology
https://www.readbyqxmd.com/read/28399158/mild-traumatic-brain-injury-mtbi-and-chronic-cognitive-impairment-a-scoping-review
#7
Kerry McInnes, Christopher L Friesen, Diane E MacKenzie, David A Westwood, Shaun G Boe
Mild traumatic brain injury (mTBI), or concussion, is the most common type of traumatic brain injury. With mTBI comes symptoms that include headaches, fatigue, depression, anxiety and irritability, as well as impaired cognitive function. Symptom resolution is thought to occur within 3 months post-injury, with the exception of a small percentage of individuals who are said to experience persistent post-concussion syndrome. The number of individuals who experience persistent symptoms appears to be low despite clear evidence of longer-term pathophysiological changes resulting from mTBI...
2017: PloS One
https://www.readbyqxmd.com/read/28390513/diagnosis-and-management-of-acute-concussion
#8
REVIEW
Michael A McCrea, Lindsay D Nelson, Kevin Guskiewicz
Over the past 2 decades, there have been major advances in the basic and clinical science of concussion and mild traumatic brain injury. These advances now provide a more evidence-informed approach to the definition, diagnosis, assessment, and management of acute concussion. Standardized clinical tools have been developed and validated for assessment of acute concussion across injury settings (eg, civilian, sport, military). Consensus guidelines now provide guidance regarding injury management and approaches to ensure safe return to activity after acute concussion...
May 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/28387693/visual-vestibular-processing-deficits-in-mild-traumatic-brain-injury
#9
W G Wright, R T Tierney, J McDevitt
BACKGROUND: The search for reliable and valid signs and symptoms of mild traumatic brain injury (mTBI), commonly synonymous with concussion, has lead to a growing body of evidence that individuals with long-lasting, unremitting impairments often experience visual and vestibular symptoms, such as dizziness, postural and gait disturbances. OBJECTIVE: Investigate the role of visual-vestibular processing deficits following concussion. METHODS: A number of clinically accepted vestibular, oculomotor, and balance assessments as well as a novel virtual reality (VR)-based balance assessment device were used to assess adults with post-acute concussion (n = 14) in comparison to a healthy age-matched cohort (n = 58)...
2017: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/28387560/clinical-evaluation-of-the-concussed-athlete-a-view-from-the-sideline
#10
Margot Putukian
CONTEXT: The sideline assessment of concussion is challenging, given its variable presentations, the limited sensitivity and specificity of sideline assessment tools, and how the presentation of the injury evolves over time. In addition, the diagnostic process, as well as the tools used to assess and manage concussion, continue to progress as research and what we know about concussion advance. This paper focuses on the initial assessment on the sideline by reviewing the concussion-evaluation literature, drawing from clinical experience to emphasize a standardized approach, and underscoring the importance of both familiarity with the athlete and clinical judgment...
March 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28387556/long-term-cognitive-and-neuropsychiatric-consequences-of-repetitive-concussion-and-head-impact-exposure
#11
Thomas McAllister, Michael McCrea
Initially, interest in sport-related concussion arose from the premise that the study of athletes engaged in sports associated with high rates of concussion could provide insight into the mechanisms, phenomenology, and recovery from mild traumatic brain injury. Over the last decade, concerns have focused on the possibility that, for some athletes, repetitive concussions may raise the long-term risk for cognitive decline, neurobehavioral changes, and neurodegenerative disease. First conceptualized as a discrete event with variable recovery trajectories, concussion is now viewed by some as a trigger of neurobiological events that may influence neurobehavioral function over the course of the life span...
March 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28387547/rest-and-return-to-activity-after-sport-related-concussion-a-systematic-review-of-the-literature
#12
Tamara C Valovich McLeod, Joy H Lewis, Kate Whelihan, Cailee E Welch Bacon
OBJECTIVE: To systematically review the literature regarding rest and return to activity after sport-related concussion. DATA SOURCES: The search was conducted in the Cochrane Central Register of Controlled Trials, CINAHL, SPORTDiscus, Educational Resources Information Center, Ovid MEDLINE, and PubMed using terms related to concussion, mild traumatic brain injury, physical and cognitive rest, and return to activity. STUDY SELECTION: Studies were included if they were published in English; were original research; and evaluated the use of, compliance with, or effectiveness of physical or cognitive rest or provided empirical evidence supporting the graded return-to-activity progression...
March 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28385102/introduction-of-the-abbreviated-westmead-post-traumatic-amnesia-scale-and-impact-on-length-of-stay
#13
C E Watson, E A Clous, M Jaeger, S K D'Amours
BACKGROUND AND AIMS: Mild traumatic brain injury is a common presentation to Emergency Departments. Early identification of patients with cognitive deficits and provision of discharge advice are important. The Abbreviated Westmead Post-traumatic Amnesia Scale provides an early and efficient assessment of post-traumatic amnesia for patients with mild traumatic brain injuries, compared with the previously used assessment, the Modified Oxford Post-traumatic Scale. MATERIAL AND METHODS: This retrospective cohort study reviewed 270 patients with mild traumatic brain injury assessed for post-traumatic amnesia over a 2-year period between February 2011 and February 2013...
April 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/28381654/disorder-of-executive-function-of-the-brain-after-head-injury-and-mild-traumatic-brain-injury-neuroimaging-and-diagnostic-criteria-for-implementation-of-administrative-support-in-japan
#14
Jun Shinoda, Yoshitaka Asano
The diagnotic criteria for disorder of the executive function of the brain (DEFB) as a syndrome of sequela were administratively established (ad-DEFB) in Japan in 2006 to support disabled patients whose impairment, limited to cognition (memory, attention, execution, and behavior), emerges after organic brain injuries regardless of physical deficits. However, some patients suffering from traumatic brain injury (TBI) have been excluded from receiving medico-social services. In particular, this tendency is more prominent in patients with mild TBI because no lesions are apparent on conventional computed tomography (CT) or magnetic resonance imaging (MRI) in the chronic phase...
April 6, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28372513/economic-evaluation-of-telephone-based-concussion-management-for-combat-related-mild-traumatic-brain-injury
#15
John S Richardson, Gregory F Guzauskas, Jesse R Fann, Nancy R Temkin, Nigel E Bush, Kathleen R Bell, Gregory A Gahm, Derek J Smolenski, Jo Ann Brockway, Ryan N Hansen
Introduction Mild traumatic brain injury (mTBI) is an unfortunately common repercussion of military service in a combat zone. The CONTACT study tested an individualized telephone support intervention employing problem solving therapy (PST) for mTBI in soldiers recently returned from deployment. We sought to determine the cost effectiveness of this intervention from a military healthcare system perspective. Methods We conducted an intent-to-treat post-hoc analysis by building a decision analytic model that evaluated the choice between using PST or education only (EO)...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28365744/normative-data-for-a-comprehensive-neuropsychological-test-battery-used-in-the-assessment-of-sports-related-concussion
#16
Victoria C Merritt, Jessica E Meyer, Margaret H Cadden, Cristina A F Roman, Dede M Ukueberuwa, Michael D Shapiro, Peter A Arnett
Objective: The use of normative data is a hallmark of the neuropsychological assessment process. Within the context of sports-related concussion, utilizing normative data is especially essential when individualized baseline data are unavailable for comparison. The primary purpose of this study was to establish normative data for a comprehensive neuropsychological test battery used in the assessment of sports-related concussion. A secondary aim was to provide normative data for pertinent demographic variables relevant to the assessment of college athletes, including sex, previous head injuries (PHI), and history of attention deficit hyperactivity disorder (ADHD)/learning disability (LD)...
March 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28358277/evaluation-of-head-and-brain-injury-risk-functions-using-sub-injurious-human-volunteer-data
#17
Erin J Sanchez, Lee F Gabler, James S McGhee, Ardyn V Olszko, Valeta Carol Chancey, Jeff Crandall, Matthew B Panzer
Risk assessment models are developed to estimate the probability of brain injury during head impact using mechanical response variables such as head kinematics and brain tissue deformation. Existing injury risk functions have been developed using different datasets based on human volunteer and scaled animal injury responses to impact. However, many of these functions have not been independently evaluated with respect to laboratory-controlled human response data. In this study, the specificity of fourteen existing brain injury risk functions was assessed by evaluating their ability to correctly predict non-injurious response using previously conducted sled tests with well-instrumented human research volunteers...
March 30, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28347935/clinical-characteristics-and-outcomes-of-treatment-of-the-cervical-spine-in-patients-with-persistent-post-concussion-symptoms-a-retrospective-analysis
#18
Ewan Kennedy, Dusty Quinn, Steve Tumilty, Cathy M Chapple
BACKGROUND: Concussion is typically defined as a mild brain injury, and yet the brain is unlikely to be the only source of persistent post-concussion symptoms. Concurrent injury to the cervical spine in particular is acknowledged as a potential source of common persistent symptoms such as headache, dizziness and neck pain. OBJECTIVES: To describe the cervical spine findings and outcomes of treatment in a series of patients with persistent post-concussion symptoms, and describe the clinical characteristics of a cervicogenic component when it is present...
March 14, 2017: Musculoskelet Sci Pract
https://www.readbyqxmd.com/read/28343463/prospective-head-to-head-study-of-three-computerized-neurocognitive-assessment-tools-part-2-utility-for-assessment-of-mild-traumatic-brain-injury-in-emergency-department-patients
#19
Lindsay D Nelson, Robyn E Furger, Peter Gikas, E Brooke Lerner, William B Barr, Thomas A Hammeke, Christopher Randolph, Kevin Guskiewicz, Michael A McCrea
OBJECTIVES: The aim of this study was to evaluate the reliability and validity of three computerized neurocognitive assessment tools (CNTs; i.e., ANAM, DANA, and ImPACT) for assessing mild traumatic brain injury (mTBI) in patients recruited through a level I trauma center emergency department (ED). METHODS: mTBI (n=94) and matched trauma control (n=80) subjects recruited from a level I trauma center emergency department completed symptom and neurocognitive assessments within 72 hr of injury and at 15 and 45 days post-injury...
March 27, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28343409/development-of-a-prediction-model-for-post-concussive-symptoms-following-mild-traumatic-brain-injury-a-track-tbi-pilot-study
#20
Maryse C Cnossen, Ethan A Winkler, John K Yue, David O Okonkwo, Alex Valadka, Ewout W Steyerberg, Hester Lingsma, Geoffrey T Manley
Post-concussive symptoms occur frequently after mild traumatic brain injury (mTBI) and may be categorized as cognitive, somatic, or emotional. We aimed to: 1) assess whether patient demographics and clinical variables predict development of each of these three symptom categories, and 2) develop a prediction model for six-month post-concussive symptoms. MTBI patients (Glasgow Coma Scale score 13-15) from the prospective multicenter Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Pilot study (2010-2012) who completed the Rivermead Post-Concussion Symptoms Questionnaire (RPQ) at six-months post-injury were included...
March 27, 2017: Journal of Neurotrauma
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