Emily Hoffmann, Max Masthoff, Wolfgang G Kunz, Max Seidensticker, Stefanie Bobe, Mirjam Gerwing, Wolfgang E Berdel, Christoph Schliemann, Cornelius Faber, Moritz Wildgruber
Our understanding of tumour biology has evolved over the past decades and cancer is now viewed as a complex ecosystem with interactions between various cellular and non-cellular components within the tumour microenvironment (TME) at multiple scales. However, morphological imaging remains the mainstay of tumour staging and assessment of response to therapy, and the characterization of the TME with non-invasive imaging has not yet entered routine clinical practice. By combining multiple MRI sequences, each providing different but complementary information about the TME, multiparametric MRI (mpMRI) enables non-invasive assessment of molecular and cellular features within the TME, including their spatial and temporal heterogeneity...
April 19, 2024: Nature Reviews. Clinical Oncology