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https://www.readbyqxmd.com/read/28318795/mechanisms-of-toxic-action-of-silver-nanoparticles-in-the-protozoan-tetrahymena-thermophila-from-gene-expression-to-phenotypic-events
#1
Katre Juganson, Monika Mortimer, Angela Ivask, Sandra Pucciarelli, Cristina Miceli, Kaja Orupõld, Anne Kahru
Silver nanoparticles (AgNPs) are highly toxic to aquatic organisms, however, there is no consensus whether the toxicity is caused solely by released Ag-ions or also by reactive oxygen species (ROS). Here, the effects of protein-coated AgNPs (14.6 nm, Collargol) were studied on viability, oxidative stress and gene expression levels in wild type strains (CU427 and CU428) of ciliate Tetrahymena thermophila. Viability-based 24 h EC50 values of AgNPs were relatively high and significantly different for the two strains: ∼100 mg/L and ∼75 mg/L for CU427 and CU428, respectively...
March 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28317643/biomarkers-for-the-diagnosis-of-alzheimer-s-disease-in-clinical-practice-an-italian-intersocietal-roadmap
#2
Giovanni B Frisoni, Daniela Perani, Stefano Bastianello, Gaetano Bernardi, Corinna Porteri, Marina Boccardi, Stefano F Cappa, Marco Trabucchi, Alessandro Padovani
Biomarkers of brain amyloidosis and neurodegeneration/synaptic dysfunction are featured in recent diagnostic criteria for Alzheimer's disease. Several gaps in our knowledge, however, need to be filled before they can be adopted clinically. The aim of this article is to describe a roadmap, developed by a multidisciplinary task force, to rationally implement biomarkers for Italian Memory Clinics. This roadmap is based on a framework comprising 5 sequential phases: identification of leads for potentially useful biomarkers; development of clinical assays for clinical disease; evaluation of detection of early stages; definition of operating characteristics in relevant populations; and estimation of reducing disease-associated mortality, morbidity, and disability...
April 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28316242/wafer-scale-synthesis-of-high-quality-semiconducting-two-dimensional-layered-inse-with-broadband-photoresponse
#3
Zhibin Yang, Wenjing Jie, Chun-Hin Mak, Shenghuang Lin, Huihong Lin, Xianfeng Yang, Feng Yan, Shu Ping Lau, Jianhua Hao
Large-scale synthesis of two-dimensional (2D) materials is one of the significant issues for fabricating layered materials into practical devices. As one of the typical III-VI semiconductors, InSe has attracted much attention due to its outstanding electrical transport property, attractive quantum physics characteristics and dramatic photoresponse when it is reduced to atomic scale. However, scalable synthesis of single phase 2D InSe has not yet been achieved so far, greatly hindering further fundamental studies and device applications...
March 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28314235/primary-and-secondary-pesticide-drift-profiles-from-a-peach-orchard
#4
Ohad Zivan, Yardena Bohbot-Raviv, Yael Dubowski
Atmospheric drift is considered a major loss path of pesticide from target areas, but there is still a large gap of knowledge regarding this complex phenomenon. Pesticide drift may occur during application (Primary drift) and after it (Secondary drift). The present study focuses on primary and secondary drift from ground applications in peach orchard (tree height of 3 m), under Mediterranean climate. Detailed and prolonged vertical drift profiles at close proximity to orchard are presented, together with detailed measurements of key meteorological parameters...
March 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28306235/gcib-tof-sims-high-resolution-imaging-of-cardiolipin-speciation-in-the-brain-identification-of-molecular-losses-after-traumatic-injury
#5
Hua Tian, Louis J Sparvero, Andrew A Amoscato, Anna Bloom, Hulya Bayir, Valerian E Kagan, Nicholas Winograd
Gas cluster ion beam secondary ion mass spectrometry (GCIB-SIMS) has shown the full potential of mapping intact lipids in biological systems with better than 10 µm lateral resolution. This study investigated further the capability of GCIB-SIMS in imaging high-mass signals from intact cardiolipin (CL) and gangliosides in normal brain and the effect of a controlled cortical impact model (CCI) of traumatic brain injury (TBI) on their distribution. A combination of enzymatic and chemical treatments was employed to suppress the signals from the most abundant phospholipids (phosphatidylcholine (PC) and phosphatidylethanolamine (PE)) and enhance the signals from the low abundance CLs and gangliosides to allow their GCIB-SIMS detection at 8 and 16 µm spatial resolution...
March 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28301244/low-pathogenic-avian-influenza-and-coinfecting-pathogens-a-review-of-experimental-infections-in-avian-models
#6
Sajid Umar, Jean Luc Guerin, Mariette F Ducatez
Low pathogenic avian influenza virus (LPAIV) usually causes mild disease or asymptomatic infection in poultry. LPAIV has, however, become a great threat to poultry industry due to mixed infections with other pathogens. Coinfections do frequently occur in the field but are not easily detected, and their impact on pathobiology is not clearly defined due to their complicated nature, but it is well known that there is an impact. One way to increase our knowledge of coinfections in poultry is to challenge birds in experimental and controlled conditions...
March 2017: Avian Diseases
https://www.readbyqxmd.com/read/28299532/coumarin-based-fluorescent-probe-for-colorimetric-detection-of-fe-3-and-fluorescence-turn-on-off-response-of-zn-2-and-cu-2
#7
Nayan Roy, Abhijit Dutta, Paritosh Mondal, Pradip C Paul, T Sanjoy Singh
A new coumarin based Schiff-base chemosensor-(E)-7-(((8-hydroxyquinolin-2-yl)methylene) amino)-4-methyl-2H-chromen-2-one (H 11 L) was synthesized and evaluated as a colorimetric sensor for Fe(3+) and fluorescence "turn on-off" response of Zn(2+) and Cu(2+) using absorption and fluorescence spectroscopy. Upon treatment with Fe(3+) and Zn(2+), the absorption intensity as well as the fluorescence emission intensity increases drastically compared to other common alkali, alkaline earth and transition metal ions, with a distinct color change which provide naked eye detection...
March 15, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28298389/screening-for-copd-the-gap-between-logic-and-evidence
#8
REVIEW
Alan Kaplan, Mike Thomas
Chronic obstructive pulmonary disease (COPD) is a common disease leading to further morbidity and significant mortality. The first step for any condition is to make the appropriate diagnosis, and spirometry barriers abound in practice around the world. It is tempting to undertake mass screening on all smokers to detect COPD. While this would pick up cases of COPD, results of studies of its effect on COPD end-points such as exacerbations, hospitalisations and mortality are disappointing. As such, aggressive case finding of COPD by screening for symptoms that patients may not themselves perceive is very important in primary care, with subsequent spirometry defining the diagnosis...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28295158/first-trimester-ultrasound-tests-alone-or-in-combination-with-first-trimester-serum-tests-for-down-s-syndrome-screening
#9
REVIEW
S Kate Alldred, Yemisi Takwoingi, Boliang Guo, Mary Pennant, Jonathan J Deeks, James P Neilson, Zarko Alfirevic
BACKGROUND: Down's syndrome occurs when a person has three, rather than two copies of chromosome 21; or the specific area of chromosome 21 implicated in causing Down's syndrome. It is the commonest congenital cause of mental disability and also leads to numerous metabolic and structural problems. It can be life-threatening, or lead to considerable ill health, although some individuals have only mild problems and can lead relatively normal lives. Having a baby with Down's syndrome is likely to have a significant impact on family life...
March 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28293675/validation-of-a-german-short-version-of-the-attitudes-towards-patient-safety-questionnaire-g-apsqshort-for-the-measurement-of-undergraduate-medical-students-attitudes-to-and-needs-for-patient-safety
#10
Jan Kiesewetter, Moritz Kager, Martin R Fischer, Isabel Kiesewetter
Introduction: Topics of patient safety are being taught increasingly within medical eudcation. To date, however, there is no suitable means of measuring the status quo of medical students' attitudes towards patient safety in German-speaking Europe. The German validation of a short version of the Attitude towards Patient Safety Questionnaire (G-APSQshort) is meant to fill this gap with the aid of two validation studies. Methods: In Study 1, item and reliability analyses were used to examine internal consistency as well as factorial structure...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/28291242/mining-outcome-relevant-brain-imaging-genetic-associations-via-three-way-sparse-canonical-correlation-analysis-in-alzheimer-s-disease
#11
Xiaoke Hao, Chanxiu Li, Lei Du, Xiaohui Yao, Jingwen Yan, Shannon L Risacher, Andrew J Saykin, Li Shen, Daoqiang Zhang
Neuroimaging genetics is an emerging field that aims to identify the associations between genetic variants (e.g., single nucleotide polymorphisms (SNPs)) and quantitative traits (QTs) such as brain imaging phenotypes. In recent studies, in order to detect complex multi-SNP-multi-QT associations, bi-multivariate techniques such as various structured sparse canonical correlation analysis (SCCA) algorithms have been proposed and used in imaging genetics studies. However, associations between genetic markers and imaging QTs identified by existing bi-multivariate methods may not be all disease specific...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28290194/inkjet-printed-photodetector-arrays-based-on-hybrid-perovskite-ch3nh3pbi3-microwires
#12
Yang Liu, Fushan Li, Chandrasekar Perumal Veeramalai, Wei Chen, Tailiang Guo, Chaoxing Wu, Tae Whan Kim
Hybrid perovskite CH3NH3PbI3 has attracted extensive research interests in optoelectronic devices in recent years. Herein, inkjet printing method has been employed to deposit a perovskite CH3NH3PbI3 layer. By choosing the proper solvent and controlling the crystal growth rate, hybrid perovskite CH3NH3PbI3 nanowires, microwires, network and islands were synthesized by means of inkjet printing. Electrode-gap-electrode lateral-structured photodetectors were fabricated with these different crystals, of which hybrid perovskite microwires-based photodetector would balance the uniformity and low defects to obtain switching ratio of 16000%, responsivity of 1...
March 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28290172/frequency-mechanism-and-severity-of-mitral-regurgitation-are-there-any-differences-between-primary-and-secondary-mitral-regurgitation
#13
José L Zamorano, Juan Manuel Monteagudo, Dolores Mesa, Teresa Gonzalez-Alujas, Marta Sitges, Fernando Carrasco-Chinchilla, Chi-Hion Li, Antonio Grande-Trillo, Amparo Martinez, Javier Matabuena, David Alonso-Rodriguez, Covadonga Fernandez-Golfin
BACKGROUND: Although mitral regurgitation (MR) is a well-recognized prognosis factor, its true prevalence is probably underestimated and its etiology and mechanisms have not been sufficiently explored. The study aim was to evaluate the burden of MR, focusing attention on its frequency, severity, etiology, mechanism, and other associated conditions. METHODS: Between February and June 2015, a total of 39,855 consecutive echocardiographic studies was performed at nine tertiary hospitals, and were prospectively included in the study...
November 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28289910/acid-base-disturbances-in-nephrotic-syndrome-analysis-using-the-co2-hco3-method-traditional-boston-model-and-the-physicochemical-method-stewart-model
#14
Tomomichi Kasagi, Hirokazu Imai, Naoto Miura, Keisuke Suzuki, Masabumi Yoshino, Hironobu Nobata, Takuhito Nagai, Shogo Banno
BACKGROUND: The Stewart model for analyzing acid-base disturbances emphasizes serum albumin levels, which are ignored in the traditional Boston model. We compared data derived using the Stewart model to those using the Boston model in patients with nephrotic syndrome. METHODS: Twenty-nine patients with nephrotic syndrome and six patients without urinary protein or acid-base disturbances provided blood and urine samples for analysis that included routine biochemical and arterial blood gas tests, plasma renin activity, and aldosterone...
March 13, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28289437/best-hits-of-11110110111-model-free-selection-and-parameter-free-sensitivity-calculation-of-spaced-seeds
#15
Laurent Noé
BACKGROUND: Spaced seeds, also named gapped q-grams, gapped k-mers, spaced q-grams, have been proven to be more sensitive than contiguous seeds (contiguous q-grams, contiguous k-mers) in nucleic and amino-acid sequences analysis. Initially proposed to detect sequence similarities and to anchor sequence alignments, spaced seeds have more recently been applied in several alignment-free related methods. Unfortunately, spaced seeds need to be initially designed. This task is known to be time-consuming due to the number of spaced seed candidates...
2017: Algorithms for Molecular Biology: AMB
https://www.readbyqxmd.com/read/28288635/urban-rural-disparities-in-hypertension-prevalence-detection-and-medication-use-among-chinese-adults-from-1993-to-2011
#16
Jiajia Li, Leiyu Shi, Shixue Li, Lingzhong Xu, Wen Qin, Heng Wang
BACKGROUND: China has experienced a rapid increase in hypertension over the past decade, especially in rural. Therefore, the aim of this research is to examine the dynamic trends in urban-rural disparities in hypertension prevalence, detection, and medication use among Chinese adults from 1993 to 2011. METHODS: Data were extracted from the seven latest waves of the China Health and Nutrition Survey (CHNS). We used the hukou system to distinguish between urban and rural residents...
March 14, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28287173/single-mode-interface-states-in-heterostructure-waveguides-with-bragg-and-non-bragg-gaps
#17
Ya-Xian Fan, Tang-Qing Sang, Ting Liu, Lan-Lan Xu, Zhi-Yong Tao
Interface states can always arise in heterostructures that consist of two or more (artificial) materials with topologically different energy bands. The gapped band structure can be classified by the Chern number (a topological invariant) generally or the Zak phase in one-dimensional periodic systems. Recently, topological properties have been employed to investigate the interface states occurring at the connecting regions of the heterostructures of mechanical isostatic lattices and acoustical waveguides. Here, we study this heterostructure phenomenon by carefully connecting two corrugated stainless steel waveguides with Bragg and non-Bragg gaps at approximately the same frequency...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28287123/near-field-terahertz-probes-with-room-temperature-nanodetectors-for-subwavelength-resolution-imaging
#18
Oleg Mitrofanov, Leonardo Viti, Enrico Dardanis, Maria Caterina Giordano, Daniele Ercolani, Antonio Politano, Lucia Sorba, Miriam S Vitiello
Near-field imaging with terahertz (THz) waves is emerging as a powerful technique for fundamental research in photonics and across physical and life sciences. Spatial resolution beyond the diffraction limit can be achieved by collecting THz waves from an object through a small aperture placed in the near-field. However, light transmission through a sub-wavelength size aperture is fundamentally limited by the wave nature of light. Here, we conceive a novel architecture that exploits inherently strong evanescent THz field arising within the aperture to mitigate the problem of vanishing transmission...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28286574/nontargeted-homologue-series-extraction-from-hyphenated-high-resolution-mass-spectrometry-data
#19
Martin Loos, Heinz Singer
BACKGROUND: A large proportion of polar anthropogenic compounds routinely released into the environment comprises homologue series, i.e., sets of chemicals differing in a repeating chemical unit. Using analytical techniques such as liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS), these compounds are readily measurable as signal sets with characteristic differences in mass and typically retention time. However, and despite such distinct characteristics, no computational approach for the direct, simultaneous and untargeted detection of all such signal sets comprising both LC and HRMS information has to date been presented...
2017: Journal of Cheminformatics
https://www.readbyqxmd.com/read/28286500/diet-induced-obesity-does-not-alter-tigecycline-treatment-efficacy-in-murine-lyme-disease
#20
Helena Pětrošová, Azad Eshghi, Zoha Anjum, Nataliya Zlotnikov, Caroline E Cameron, Tara J Moriarty
Obese individuals more frequently suffer from infections, as a result of increased susceptibility to a number of bacterial pathogens. Furthermore, obesity can alter antibiotic treatment efficacy due to changes in drug pharmacokinetics which can result in under-dosing. However, studies on the treatment of bacterial infections in the context of obesity are scarce. To address this research gap, we assessed efficacy of antibiotic treatment in diet-induced obese mice infected with the Lyme disease pathogen, Borrelia burgdorferi...
2017: Frontiers in Microbiology
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